CA2516950A1 - Anti-sensitivity, anti-caries, anti-staining, anti-plaque, ultra-mild oral hygiene agent - Google Patents
Anti-sensitivity, anti-caries, anti-staining, anti-plaque, ultra-mild oral hygiene agent Download PDFInfo
- Publication number
- CA2516950A1 CA2516950A1 CA002516950A CA2516950A CA2516950A1 CA 2516950 A1 CA2516950 A1 CA 2516950A1 CA 002516950 A CA002516950 A CA 002516950A CA 2516950 A CA2516950 A CA 2516950A CA 2516950 A1 CA2516950 A1 CA 2516950A1
- Authority
- CA
- Canada
- Prior art keywords
- composition
- agent
- tooth
- cleaning product
- tooth cleaning
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/55—Phosphorus compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
Abstract
This invention relates to a composition useful as a dentifrice comprising a surfactant agent consisting essentially of monoalkyl and dialkyl phosphate esters, wherein the ratio of monoesters to diesters is greater than 1, and optionally an abrasive agent consisting essentially of siliceous materials.
Claims (40)
1. A composition for reducing hypersensitivity in teeth comprising a surfactant agent consisting essentially of water soluble monoalkyl and dialkyl phosphate esters, wherein the ratio of monoesters to diesters is greater than 1.
2. The composition of claim 1 wherein said phosphate esters are based on a single alcohol or blend of alcohols.
3. The composition of claim 1 wherein a hydrocarbon group of said phosphate esters are linear or branched.
4. The composition of claim 1 wherein a hydrocarbon group of said phosphate esters are saturated or unsaturated.
5. The composition of claim 1 wherein a hydrocarbon group of said phosphate esters comprise from about 8 to about 22 carbon atoms.
6. The composition of claim 5 wherein said phosphate ester has a degree of ethoxylation or propoxylation from between about 0 to about 20.
7. The composition of claim 1 wherein said phosphate esters have a monoalkyl to dialkyl eser molar ratio of 70 : 30 to 100: 0.
8. The composition of claim 1 wherein said phosphate esters comprise potassium dodecyl phosphate.
9. The composition of claim 1 further comprising an abrasive agent consisting essentially of siliceous materials.
10. An oral care anti-hypersensitivity agent comprising an effective amount of water soluble monoalkyl and dialkyl phosphate ester salts to reduce tooth sensitivity.
11. The composition of claim 10 wherein the ratio of monoalkyl esters to dialkyl esters is at least 1.
12. The composition of claim 10 further comprising an abrasive agent consisting essentially of siliceous materials.
13. A tooth cleaning product comprising a surfactant agent consisting essentially of water soluble salts of monoalkyl and dialkyl phosphate esters, wherein the molar ratio of monoalkyl esters to dialkyl esters is greater than 1, an abrasive agent and optionally a liquid.
14. The tooth cleaning product of claim 13 wherein said abrasive agent is an abrasive system comprising one or more of hydrated silica, colloidal silica, fumed silica, insoluble sodium metaphosphate, insoluble sodium aluminosilicates, sodium bicarbonate or mixtures thereof.
15. The tooth cleaning product of claim 14 wherein said abrasive system is in amount of from about 5% to about 70% by weight of the tooth cleaning product.
16. The tooth cleaning product of claim 13 wherein said tooth cleaning product is a toothpaste or a tooth cleaning gel.
17. The tooth cleaning product of claim 16 wherein said liquid comprises one or more of water, humectant, binder, or a mixture thereof.
18. The tooth cleaning product of claim 13 wherein said liquid is in an amount of from about 10% to about 90% by weight of the tooth cleaning product.
19. The tooth cleaning product of claim 17 wherein said humectant is in an amount of from about 5% to about 85% of the tooth cleaning product.
20. The tooth cleaning product of claim 17 wherein said tooth cleaning product is a translucent gel having a humectant to water ratio of at least about 0.5 to 1.
21. A tooth powder comprising:
(c) an effective amount of a water soluble monoalkyl dialkyl mixture of phosphate ester salts to reduce tooth sensitivity; and (d) from about 20% to about 95% by weight of a polishing agent.
(c) an effective amount of a water soluble monoalkyl dialkyl mixture of phosphate ester salts to reduce tooth sensitivity; and (d) from about 20% to about 95% by weight of a polishing agent.
22. The tooth powder of claim 21 wherein said effective amount of phosphate ester salts is from about 0.1% to about 10% by weight of said tooth powder.
23. The tooth powder of claim 22 wherein said effective amount of phosphate ester salts is from about 1% to about 5% by weight of said tooth powder.
24. The tooth powder of claim 21 comprising from over 50% by weight polishing agent.
25. The tooth powder of claim 21 further comprising one or more of a flavoring agent, sweetening agent, an anti-calculus agent, an anti-caries agent.
buffering agents, or processing aids.
buffering agents, or processing aids.
26. A mouthwash comprising:
(e) an effective amount of a water soluble mixture of monoalkyl and dialkyl phosphate ester salts to reduce tooth sensitivity;
(f) alcohol;
(g) humectant; and (h) water.
(e) an effective amount of a water soluble mixture of monoalkyl and dialkyl phosphate ester salts to reduce tooth sensitivity;
(f) alcohol;
(g) humectant; and (h) water.
27. The mouthwash of claim 26 wherein said effective amount of said water soluble phosphate ester salt is from about 0.1% to about 10% by weight of the mouthwash.
28. The mouthwash of claim 27 wherein said effective amount of said water soluble phosphate ester salt is from about 1% to about 5% by weight of the mouthwash.
29. The mouthwash of claim 26 further comprising one or more of a flavoring agent, sweetening agent, an anti-calculus agent , an anti-caries agent, buffering agents, or processing aids.
30. An oral care composition having anti-sensitivity effect upon teeth which contains an essential anti-sensitivity agent which essentially comprises:
(a) an effective amount of a water soluble mixture of monoalkyl and dialkyl phosphate ester salts.
(a) an effective amount of a water soluble mixture of monoalkyl and dialkyl phosphate ester salts.
31. A toothpaste comprising the oral care composition of claim 30.
32. A chewing gum comprising the oral care composition of claim 30.
33. A mouthwash comprising the oral care composition of claim 30.
34. An oral care strip comprising the oral care composition of claim 30.
35. A lozenge comprising the oral care composition of claim 30.
36. An oral care composition comprising an effective amount of a water soluble alkali metal or a functional amine salt of a phosphate ester, effective to reduce sensitivity in teeth.
37. The composition of claim 36 wherein said water soluble alkali metal salt comprises lithium, sodium, potassium or a mixture thereof.
38. The composition of claim 36 wherein said functional amine comprises a trialkanolamine.
39. The composition of claim 36 wherein said functional amine comprises a basic amino acid.
40. An oral care compositon comprising an effective amount of salts of monoalkyl or monoalkenyl phosphates of Structure (I) and water soluble salts of dialkyl or dialkenyl phosphates of Structure (II):
wherein R1, R2 and R3 are from 8 to 22 carbon atoms; n and m are 2 to 4; a and b are 0 to 20; one of Z1 or Z2 is selected from the group consisting of an alkali metal, an ammonium, protonated alkyl amine, protonated alkanolamine or a protonated basic amino acid; and the other of Z1 or Z2 is selected from the group consisting of hydrogen, an alkali metal, an ammonium, protonated alkyl amine, protonated alkanolamine, or a protoanted basic amino acid; and Z3 is selected from a group consisting of an alkali metal, an ammonium, protonated alkyl amine or protonated alkanolamine, or a protonated basic amino acid.
wherein R1, R2 and R3 are from 8 to 22 carbon atoms; n and m are 2 to 4; a and b are 0 to 20; one of Z1 or Z2 is selected from the group consisting of an alkali metal, an ammonium, protonated alkyl amine, protonated alkanolamine or a protonated basic amino acid; and the other of Z1 or Z2 is selected from the group consisting of hydrogen, an alkali metal, an ammonium, protonated alkyl amine, protonated alkanolamine, or a protoanted basic amino acid; and Z3 is selected from a group consisting of an alkali metal, an ammonium, protonated alkyl amine or protonated alkanolamine, or a protonated basic amino acid.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US44912803P | 2003-02-21 | 2003-02-21 | |
| US60/449,128 | 2003-02-21 | ||
| PCT/US2004/005004 WO2004075770A2 (en) | 2003-02-21 | 2004-02-20 | Anti-sensitivity, anti-caries, anti-staining, anti-plaque, ultra-mild oral hygiene agent |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CA2516950A1 true CA2516950A1 (en) | 2004-09-10 |
| CA2516950C CA2516950C (en) | 2012-09-25 |
Family
ID=32927496
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA2516950A Expired - Lifetime CA2516950C (en) | 2003-02-21 | 2004-02-20 | Anti-sensitivity, anti-caries, anti-staining, anti-plaque, ultra-mild oral hygiene agent |
Country Status (10)
| Country | Link |
|---|---|
| US (3) | US20040185027A1 (en) |
| EP (2) | EP2281550A3 (en) |
| JP (1) | JP2006518744A (en) |
| KR (1) | KR20050105230A (en) |
| CN (1) | CN1750807B (en) |
| BR (1) | BRPI0407746A (en) |
| CA (1) | CA2516950C (en) |
| MX (1) | MXPA05008302A (en) |
| RU (1) | RU2337734C2 (en) |
| WO (1) | WO2004075770A2 (en) |
Families Citing this family (35)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9139731B2 (en) * | 1999-11-12 | 2015-09-22 | The Procter & Gamble Company | Compositions and methods for improving overall tooth health and appearance |
| US20060142174A1 (en) * | 2003-04-14 | 2006-06-29 | Kao Corporation | Cleaning agent composition |
| BRPI0512478A (en) | 2004-07-02 | 2008-03-11 | Discus Dental Impressions Inc | prescription fluoride treatment composition |
| WO2006081912A1 (en) * | 2005-02-04 | 2006-08-10 | Unilever N.V. | Multiphase toothpaste composition |
| ES2340795T3 (en) * | 2005-02-04 | 2010-06-09 | Unilever N.V. | MULTIPHASE DENTRIFY PASTE COMPOSITION. |
| EP1845930A1 (en) * | 2005-02-04 | 2007-10-24 | Unilever N.V. | Multiphase toothpaste composition |
| US20080187497A1 (en) * | 2005-02-04 | 2008-08-07 | Rupesh Kumar Agarwal | Toothpaste |
| US8993506B2 (en) | 2006-06-12 | 2015-03-31 | Rhodia Operations | Hydrophilized substrate and method for hydrophilizing a hydrophobic surface of a substrate |
| GB0621329D0 (en) * | 2006-10-26 | 2006-12-06 | Glaxo Group Ltd | Novel composition |
| AU2008266172B2 (en) * | 2007-06-12 | 2014-04-17 | Rhodia Inc. | Mono-, di- and polyol alkoxylate phosphate esters in oral care formulations and methods for using same |
| EP2152839B1 (en) | 2007-06-12 | 2018-11-14 | Solvay USA Inc. | Detergent composition with hydrophilizing soil-release agent and methods for using same |
| JP5613558B2 (en) * | 2007-06-12 | 2014-10-22 | ローディア インコーポレイティド | Mono-, di- and polyol phosphate esters in personal care formulations |
| CN101679915B (en) | 2007-06-12 | 2013-01-23 | 罗迪亚公司 | Hard surface cleaning composition with hydrophilizing agent and method for cleaning hard surfaces |
| CN101095656B (en) * | 2007-07-19 | 2010-11-03 | 法国医药集团 | Application of Andrographis paniculata in the preparation of tooth cleaning articles and the tooth cleaning articles thereof |
| EP2384740A3 (en) * | 2008-02-08 | 2016-05-18 | Colgate-Palmolive Company | Oral care product and methods of use and manufacture thereof |
| RU2476890C2 (en) * | 2008-02-08 | 2013-02-27 | Колгейт-Палмолив Компани | Oral care methods and systems |
| BRPI0925317B1 (en) * | 2009-04-02 | 2016-11-29 | Colgate Palmolive Co | toothpaste composition |
| CN102802732B (en) * | 2009-09-11 | 2016-04-27 | 宝洁公司 | For the method and composition of oral surfaces hydrophobically modified |
| US8523475B2 (en) * | 2009-12-23 | 2013-09-03 | Colgate-Palmolive Company | Oral care system, kit and method |
| AU2010333783B2 (en) | 2009-12-23 | 2014-01-30 | Colgate-Palmolive Company | Oral care system |
| US8658139B1 (en) | 2010-02-27 | 2014-02-25 | Squigle, Inc. | Prevention and treatment of oral diseases |
| US9358185B2 (en) | 2012-06-18 | 2016-06-07 | 3M Innovative Properties Company | Powder composition for air polishing the surface of hard dental tissue |
| EP2742898A1 (en) | 2012-12-17 | 2014-06-18 | 3M Innovative Properties Company | Powder jet device for dispensing a dental material |
| EP2742897A1 (en) | 2012-12-17 | 2014-06-18 | 3M Innovative Properties Company | Nozzle head, hand piece and powder jet device for applying a dental material |
| US9662180B2 (en) | 2012-12-17 | 2017-05-30 | 3M Innovative Properties Company | Device for dispensing a dental material with locking mechanism |
| US9801916B2 (en) * | 2013-02-07 | 2017-10-31 | Tomás Bernardo Galvan Gonzalez | Oral antiseptic composition useful for treating oral mucositis |
| IN2013DE03528A (en) * | 2013-12-05 | 2015-06-12 | Colgate Palmolive Co | |
| CN104248516B (en) * | 2014-08-11 | 2017-06-06 | 秦俊远 | A kind of preparation method of the tooth whitening pad pasting without peroxide |
| CN106999407B (en) * | 2014-11-13 | 2020-11-17 | 罗地亚经营管理公司 | Ablative, renewable, multifunctional protective coatings for tooth surfaces |
| US9993408B2 (en) | 2015-09-17 | 2018-06-12 | Johnson & Johnson Consumer Inc. | Compositions comprising zwitterionic alkyl-alkanoylamides and/or alkyl alkanoates |
| WO2017062020A1 (en) * | 2015-10-08 | 2017-04-13 | Colgate-Palmolive Company | Oral care compositions |
| KR101956579B1 (en) | 2018-05-09 | 2019-03-11 | 주식회사 하이센스바이오 | Toothpaste composition for alleviating dentine hyperesthesia |
| KR101956578B1 (en) | 2018-05-09 | 2019-03-11 | 주식회사 하이센스바이오 | Oral care composition for alleviating dentine hyperesthesia |
| AU2019403912B2 (en) | 2018-12-20 | 2022-09-29 | Colgate-Palmolive Company | Dentifrice containing sodium bicarbonate and stannous fluoride |
| EP3979980A4 (en) * | 2019-06-05 | 2023-08-02 | Rhodia Operations | Oral care composition |
Family Cites Families (42)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1408922A (en) | 1972-02-02 | 1975-10-08 | Blendax Werke Schneider Co | Process and composition for the remineralisation and prevention of demineralisation of human teeth |
| GB1475251A (en) * | 1975-01-15 | 1977-06-01 | Colgate Palmolive Co | Oral preparations |
| US4083955A (en) * | 1975-04-02 | 1978-04-11 | The Procter & Gamble Company | Processes and compositions for remineralization of dental enamel |
| JPS5927323B2 (en) * | 1976-10-12 | 1984-07-05 | 花王株式会社 | toothpaste composition |
| US4264580A (en) | 1979-04-23 | 1981-04-28 | Barberio Giacinto G | Dental cream composition |
| GB2084463B (en) | 1980-09-24 | 1984-05-31 | Colgate Palmolive Co | Dentifrices |
| NO158361C (en) * | 1981-07-03 | 1988-08-31 | Intradal Nv | DENTAL CARE WITH ANTICARIES EFFECT. |
| IL65187A (en) * | 1982-03-08 | 1985-03-31 | Geshuri Lab Ltd | N-phosphonomethylglycine derivatives,processes for their preparation and herbicidal compositions containing them |
| US4522805A (en) * | 1983-06-08 | 1985-06-11 | Norman Gordon | Tooth and gum dentifrice |
| US4971782A (en) * | 1983-09-14 | 1990-11-20 | Peroxydent Group | Periodontal composition and method |
| GB8527962D0 (en) * | 1985-11-13 | 1985-12-18 | Neirinckx R D | Desensitizing dental composition |
| GB8828017D0 (en) * | 1988-12-01 | 1989-01-05 | Unilever Plc | Topical composition |
| GB8828018D0 (en) * | 1988-12-01 | 1989-01-05 | Unilever Plc | Topical composition |
| US5244651A (en) * | 1991-09-04 | 1993-09-14 | Kao Corporation | Method of desensitizing hypersensitive dentin |
| US5374418A (en) * | 1992-02-13 | 1994-12-20 | Kao Corporation | Composition for use in oral cavity |
| US5370865A (en) | 1992-05-15 | 1994-12-06 | Kao Corporation | Composition for use in oral cavity |
| JPH05320032A (en) | 1992-05-20 | 1993-12-03 | Kao Corp | Composition for oral cavity application |
| US5292502A (en) * | 1992-07-02 | 1994-03-08 | Colgate-Palmolive Co. | Non-irritating dentifrice |
| JPH0692860A (en) * | 1992-09-14 | 1994-04-05 | Kao Corp | Therapeutic agent for hypersthesia |
| JPH0813251B2 (en) | 1993-07-14 | 1996-02-14 | 長岡香料株式会社 | Taste improving solution containing iron and / or magnesium and / or calcium |
| US5554781A (en) | 1994-03-30 | 1996-09-10 | Reierson; Robert L. | Monoalkyl phosphonic acid ester production process |
| US5550274A (en) | 1994-03-30 | 1996-08-27 | Reierson; Robert L. | In-situ phosphation reagent process |
| FI104881B (en) | 1994-10-06 | 2000-04-28 | Bioxid Oy | Process for the preparation of novel compositions containing bioactive silicon glass |
| US5605675A (en) | 1995-06-06 | 1997-02-25 | Enamelon Inc. | Processes and compositions for remineralization and prevention of demineralization of dental enamel |
| US5605676A (en) | 1995-06-26 | 1997-02-25 | Colgate-Palmolive Company | Oral composition exhibiting improved uptake and retention of antibacterial compounds on dental tissue surfaces |
| US6110445A (en) * | 1995-06-26 | 2000-08-29 | Colgate-Palmotive Company | Oral composition exhibiting improved uptake and retention of antibacterial compounds on dental tissue surfaces |
| US5603922A (en) | 1995-08-08 | 1997-02-18 | Enamelon Inc. | Processes and compositions for the remineralization of teeth |
| US5628429A (en) * | 1995-11-22 | 1997-05-13 | Enamelon, Inc. | Plural chambered squeezable dispensing tube |
| US6713049B1 (en) * | 1999-11-12 | 2004-03-30 | The Procter & Gamble Company | Oral compositions providing optimal surface conditioning |
| JP3793621B2 (en) | 1997-04-25 | 2006-07-05 | 花王株式会社 | Perceptual oral composition |
| US6464963B1 (en) | 1998-04-23 | 2002-10-15 | Colgate Palmolive Company | Desensitizing dentifrice containing potassium and tin salts |
| DE69919737T2 (en) | 1998-11-24 | 2005-09-01 | Rhodia Inc. | PUMPABLE AQUEOUS COMPOSITIONS HAVING A HIGH SOLIDS CONTENT AND A HIGH CONSUMPTION ON MONOAL CYLPHOSPHATE SALT |
| US7387774B2 (en) * | 1999-11-12 | 2008-06-17 | The Procter & Gamble Co. | Method of enhancing fluoridation and mineralization of teeth |
| US9139731B2 (en) * | 1999-11-12 | 2015-09-22 | The Procter & Gamble Company | Compositions and methods for improving overall tooth health and appearance |
| US6685920B2 (en) * | 1999-11-12 | 2004-02-03 | The Procter & Gamble Company | Method of protecting teeth against erosion |
| US20040146466A1 (en) * | 1999-11-12 | 2004-07-29 | The Procter & Gamble Company | Method of protecting teeth against erosion |
| US6926916B1 (en) * | 1999-11-12 | 2005-08-09 | The Procter & Gamble Company | Chewing gum compositions |
| US20020041852A1 (en) * | 2000-08-18 | 2002-04-11 | Napolitano Neil J. | Dental composition for hypersensitive teeth |
| AR030713A1 (en) * | 2000-08-21 | 2003-09-03 | Block Drug Co | DENTAL COMPOSITION TO REDUCE DENTINAL HYPERSENSITIVITY DUE TO THE PRESENCE OF EXPOSED DENTINAL SURFACE AND OPEN DENTINAL TUBES, USE OF A SYNERGIC COMBINATION OF A SENSITIZING AMOUNT OF AT LEAST A BLOCKING AGENT OF A TUBULATOR NEEDLE |
| US6416745B1 (en) * | 2001-05-03 | 2002-07-09 | Block Drug Company, Inc. | Dental composition for treating hypersensitive teeth |
| ATE341391T1 (en) | 2001-06-04 | 2006-10-15 | Rhodia | PUMPABLE LIQUID SURFACTANT COMPOSITIONS COMPRISING ALKANOLAMIN SALTS OF ALKYLPHOSPHATE ESTERS |
| GB0621329D0 (en) | 2006-10-26 | 2006-12-06 | Glaxo Group Ltd | Novel composition |
-
2004
- 2004-02-20 US US10/783,721 patent/US20040185027A1/en not_active Abandoned
- 2004-02-20 CN CN2004800045789A patent/CN1750807B/en not_active Expired - Fee Related
- 2004-02-20 BR BRPI0407746-6A patent/BRPI0407746A/en not_active IP Right Cessation
- 2004-02-20 EP EP10172254A patent/EP2281550A3/en not_active Withdrawn
- 2004-02-20 MX MXPA05008302A patent/MXPA05008302A/en unknown
- 2004-02-20 JP JP2006503730A patent/JP2006518744A/en active Pending
- 2004-02-20 EP EP04713361A patent/EP1599182A4/en not_active Ceased
- 2004-02-20 CA CA2516950A patent/CA2516950C/en not_active Expired - Lifetime
- 2004-02-20 RU RU2005129336/15A patent/RU2337734C2/en not_active IP Right Cessation
- 2004-02-20 WO PCT/US2004/005004 patent/WO2004075770A2/en active Application Filing
- 2004-02-20 KR KR1020057015384A patent/KR20050105230A/en not_active Application Discontinuation
-
2009
- 2009-01-13 US US12/319,856 patent/US9034308B2/en active Active
- 2009-03-05 US US12/380,971 patent/US9040025B2/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| CA2516950C (en) | 2012-09-25 |
| WO2004075770A2 (en) | 2004-09-10 |
| US9034308B2 (en) | 2015-05-19 |
| JP2006518744A (en) | 2006-08-17 |
| EP2281550A3 (en) | 2012-07-18 |
| BRPI0407746A (en) | 2006-02-14 |
| US9040025B2 (en) | 2015-05-26 |
| US20090169493A1 (en) | 2009-07-02 |
| MXPA05008302A (en) | 2005-09-20 |
| RU2337734C2 (en) | 2008-11-10 |
| EP2281550A2 (en) | 2011-02-09 |
| KR20050105230A (en) | 2005-11-03 |
| WO2004075770A3 (en) | 2005-03-10 |
| EP1599182A2 (en) | 2005-11-30 |
| CN1750807A (en) | 2006-03-22 |
| US20040185027A1 (en) | 2004-09-23 |
| EP1599182A4 (en) | 2008-08-20 |
| CN1750807B (en) | 2010-05-12 |
| US20090123396A1 (en) | 2009-05-14 |
| RU2005129336A (en) | 2006-03-10 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EEER | Examination request |