CA2514844A1 - Improved capacity chemical suppressors and method of use - Google Patents

Improved capacity chemical suppressors and method of use Download PDF

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Publication number
CA2514844A1
CA2514844A1 CA002514844A CA2514844A CA2514844A1 CA 2514844 A1 CA2514844 A1 CA 2514844A1 CA 002514844 A CA002514844 A CA 002514844A CA 2514844 A CA2514844 A CA 2514844A CA 2514844 A1 CA2514844 A1 CA 2514844A1
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CA
Canada
Prior art keywords
flow channel
ion exchange
sample stream
ion
ions
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA002514844A
Other languages
French (fr)
Other versions
CA2514844C (en
Inventor
Kannan Srinivasan
Christopher A. Pohl
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Dionex Corp
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2514844A1 publication Critical patent/CA2514844A1/en
Application granted granted Critical
Publication of CA2514844C publication Critical patent/CA2514844C/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

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Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/96—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation using ion-exchange
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
    • B01D15/08—Selective adsorption, e.g. chromatography
    • B01D15/26—Selective adsorption, e.g. chromatography characterised by the separation mechanism
    • B01D15/36—Selective adsorption, e.g. chromatography characterised by the separation mechanism involving ionic interaction
    • B01D15/367—Ion-suppression
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D61/00—Processes of separation using semi-permeable membranes, e.g. dialysis, osmosis or ultrafiltration; Apparatus, accessories or auxiliary operations specially adapted therefor
    • B01D61/42—Electrodialysis; Electro-osmosis ; Electro-ultrafiltration; Membrane capacitive deionization
    • B01D61/44—Ion-selective electrodialysis
    • B01D61/46—Apparatus therefor
    • B01D61/48—Apparatus therefor having one or more compartments filled with ion-exchange material, e.g. electrodeionisation
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D61/00—Processes of separation using semi-permeable membranes, e.g. dialysis, osmosis or ultrafiltration; Apparatus, accessories or auxiliary operations specially adapted therefor
    • B01D61/42—Electrodialysis; Electro-osmosis ; Electro-ultrafiltration; Membrane capacitive deionization
    • B01D61/44—Ion-selective electrodialysis
    • B01D61/52—Accessories; Auxiliary operation
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D61/00—Processes of separation using semi-permeable membranes, e.g. dialysis, osmosis or ultrafiltration; Apparatus, accessories or auxiliary operations specially adapted therefor
    • B01D61/42—Electrodialysis; Electro-osmosis ; Electro-ultrafiltration; Membrane capacitive deionization
    • B01D61/44—Ion-selective electrodialysis
    • B01D61/54—Controlling or regulating
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D2325/00—Details relating to properties of membranes
    • B01D2325/42—Ion-exchange membranes
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/25—Chemistry: analytical and immunological testing including sample preparation

Abstract

A non-electrolytic method and apparatus for treating an aqueous sample stream including analyte ions and matrix ions of opposite charge, for pretreatment or suppression. The apparatus includes an ion exchange membrane capable of passing only ions of opposite charge to the analyte ions, a sample stream flow channel, a first aqueous stream ion receiving flow channel adjacent one side of the sample stream flow channel and separated therefrom by the first ion exchange membrane, and stationary flow-through ion exchange packing disposed in the sample stream flow channel. The ion receiving channel has an ion exchange capacity for the matrix ions less than about 25% of the ion exchange capacity for the matrix ions.

Claims (26)

1. A non-electrolytic apparatus for treating an aqueous sample stream including analyte ions and matrix ions of opposite charge, said apparatus comprising a first ion exchange membrane capable of passing only ions of opposite charge to said analyte ions, a sample stream flow channel, a first aqueous stream ion receiving flow channel adjacent one side of said sample stream flow channel and separated therefrom by said first ion exchange membrane, stationary flow-through first packing of ion exchange material disposed in the sample stream flow channel of the same charge as said first membrane and having a first ion exchange capacity for said matrix ions, said first ion receiving channel having an ion exchange capacity for said matrix ions less than about 25% of said first ion exchange capacity for said matrix ions, said apparatus not including electrodes disposed to apply an electric field between said sample stream flow channel and said first ion receiving flow channel.
2. The apparatus of Claim 1 further comprising a second ion exchange membrane of the same charge as said first ion exchange membrane, and a second aqueous stream ion receiving flow channel disposed adjacent the other side of said sample stream flow and separated therefrom by said second ion exchange membrane.
3. The apparatus of Claim 1 in which said first ion receiving flow channel is substantially free of ion exchange capacity for said matrix ions.
4. The apparatus of Claim 1 further comprising neutral flow-through packing in said first ion receiving flow channel.
5. The apparatus of Claim 2 further comprising second flow-through ion exchange packing of opposite charge to said first ion exchange packing disposed in said first ion receiving flow channel.
6. The apparatus of Claim 2 in which the second aqueous stream ion receiving flow channel has an ion exchange capacity for said matrix ions less than about 25%
of said first ion exchange capacity for said matrix ions.
7. The apparatus of Claim 1 in ion chromatography apparatus, further comprising a chromatography separator in fluid communication with the inlet of said sample stream flow channel and a detector for said analyze ions in fluid communication with the outlet of said sample flow channel.
8. The apparatus of Claim 1 for treatment of a sample stream in combination with a chromatography apparatus, said apparatus further comprising a chromatography separator having an inlet and an outlet, said inlet being in fluid communication with said sample stream, and a detector in fluid communication with said chromatography separator.
9. The apparatus of Claim 1 in which said first packing comprises a screen.
10. A non-electrolytic method for treating an aqueous sample stream including analyze ions of one charge and matrix ions of opposite charge to said analyte ions, said method comprising flowing the sample stream through a sample stream flow channel, simultaneously flowing an aqueous stream through an ion receiving flow channel separated therefrom by a first ion exchange membrane capable of passing only ions of opposite charge to said analyte ions and of blocking bulk liquid flow to reduce the concentration of said matrix ions in an effluent from said sample stream flow channel, said sample strew flow channel having stationary flow-through first packing of ion exchange material disposed in the sample stream flow channel of the same charge as said first membrane and having a first ion exchange capacity for said matrix ions, said ion receiving channel having an ion exchange capacity for said matrix ions less than about 25 % of said first ion exchange capacity for said matrix ion, an electric field not being applied between said sample stream flow channel and said first ion receiving flow channel.
11. The method of Claim 10 in which said first ion receiving flow channel is substantially free of ion exchange capacity for said matrix ions.
12. The method of Claim 10 in which second flow-through ion exchange packing of opposite charge to said first ion exchange packing is disposed in said first ion receiving flow channel.
13. The method of Claim 10 further comprising flowing said aqueous sample stream through a chromatographic separator to separate the analyte ions prior to flowing said sample stream through said sample stream flow channel, and then detecting said separated analyte ions.
14. A chromatography apparatus including apparatus for treating an aqueous sample stream including analyte ions and matrix ions of opposite charge, said apparatus comprising a chromatography separator having an inlet and an outlet, said inlet being in fluid communication with said sample stream, said treating apparatus being disposed upstream or downstream from said chromatography separator and comprising a first ion exchange membrane capable of passing only ions of opposite charge to said analyte ions, a sample stream flow channel, a first aqueous stream ion receiving flow channel adjacent one side of said sample stream flow channel and separated therefrom by said first ion exchange membrane, stationary flow-through first packing of ion exchange material disposed in the sample stream flow channel of the same charge as said first membrane and having a first ion exchange capacity for said matrix ions, said first ion receiving channel having an ion exchange capacity for said matrix ions less than about 25% of said first ion exchange capacity for said matrix ions.
15. The chromatography apparatus of Claim 14 in which said treating apparatus further comprises a second ion exchange membrane of the same charge as said first ion exchange membrane, and a second aqueous stream ion receiving flow channel disposed adjacent the other side of said sample stream flow and separated therefrom by said second ion exchange membrane.
16. The apparatus of Claim 14 in which said first ion receiving flow channel is substantially free of ion exchange capacity for said matrix ions.
17. The apparatus of Claim 14 further comprising neutral flow-through packing in said first ion receiving flow channel.
18. The apparatus of Claim 15 further comprising second flow-through ion exchange packing of opposite charge to said first ion exchange packing disposed in said first ion receiving flow channel.
19. The apparatus of Claim 14 in ion chromatography apparatus, in which said chromatography separator is in fluid communication with the inlet of said sample stream flow channel.
20. The apparatus of Claim 14 further comprising a detector in fluid communication with said chromatography suppressor
21. The apparatus of Claim 14 without electrodes for applying an electric field between said sample stream flow channel and first ion receiving flow channel.
22. A chromatography method comprising flowing an aqueous sample stream including analyte ions of one charge and matrix ions of opposite charge to said analyte ions through a chromatography separator to separate the analyte ions, flowing the sample stream including the separated analyte ions through a sample stream flow channel, and simultaneously flowing an aqueous stream through an ion receiving flow channel separated therefrom by a first ion exchange membrane capable of passing only ions of opposite charge to said analyte ions and of blocking bulk liquid flow to reduce the concentration of said matrix ions in an effluent from said sample stream flow channel, said sample stream flow channel having stationary flow-through first packing of ion exchange material disposed in the sample stream flow channel of the same charge as said first membrane and having a first ion exchange capacity for said matrix ions, said ion receiving channel having an ion exchange capacity for said matrix ions less than about 25% of said first ion exchange capacity for said matrix ion.
23. The method of Claim 22 in which said first ion receiving flow channel is substantially free of ion exchange capacity for said matrix ions.
24. The method of Claim 22 in which second flow-through ion exchange packing of opposite charge to said first ion exchange packing is disposed in said first ion receiving flow channel.
25. The method of Claim 22 further comprising detecting said separated analyte ions in the sample stream exiting from said sample stream flow channel.
26. The method of Claim 22 in which an electric field is not applied between said sample stream flow channel and said first ion receiving flow channel.
CA2514844A 2003-01-30 2003-12-09 Improved capacity chemical suppressors and method of use Expired - Fee Related CA2514844C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US10/356,345 2003-01-30
US10/356,345 US7517696B2 (en) 2003-01-30 2003-01-30 Chemical suppressors and method of use
PCT/US2003/039219 WO2004070377A2 (en) 2003-01-30 2003-12-09 Improved capacity chemical suppressors and method of use

Publications (2)

Publication Number Publication Date
CA2514844A1 true CA2514844A1 (en) 2004-08-19
CA2514844C CA2514844C (en) 2010-09-14

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
CA2514844A Expired - Fee Related CA2514844C (en) 2003-01-30 2003-12-09 Improved capacity chemical suppressors and method of use

Country Status (8)

Country Link
US (3) US7517696B2 (en)
EP (1) EP1587597B1 (en)
JP (1) JP4485368B2 (en)
KR (1) KR20050098876A (en)
CN (1) CN1764493A (en)
AU (1) AU2003296431B2 (en)
CA (1) CA2514844C (en)
WO (1) WO2004070377A2 (en)

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Also Published As

Publication number Publication date
US8636963B2 (en) 2014-01-28
JP2006514279A (en) 2006-04-27
WO2004070377A2 (en) 2004-08-19
CN1764493A (en) 2006-04-26
AU2003296431A1 (en) 2004-08-30
EP1587597B1 (en) 2019-01-23
AU2003296431B2 (en) 2009-07-16
US20040149581A1 (en) 2004-08-05
EP1587597A2 (en) 2005-10-26
US20090166293A1 (en) 2009-07-02
KR20050098876A (en) 2005-10-12
JP4485368B2 (en) 2010-06-23
US20120141328A1 (en) 2012-06-07
WO2004070377A3 (en) 2005-01-13
US7517696B2 (en) 2009-04-14
CA2514844C (en) 2010-09-14

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Effective date: 20210831

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Effective date: 20191209