CA2512290A1 - Method and apparatus for desorption and ionization of analytes - Google Patents
Method and apparatus for desorption and ionization of analytes Download PDFInfo
- Publication number
- CA2512290A1 CA2512290A1 CA002512290A CA2512290A CA2512290A1 CA 2512290 A1 CA2512290 A1 CA 2512290A1 CA 002512290 A CA002512290 A CA 002512290A CA 2512290 A CA2512290 A CA 2512290A CA 2512290 A1 CA2512290 A1 CA 2512290A1
- Authority
- CA
- Canada
- Prior art keywords
- probe
- energy absorbing
- absorbing molecules
- analyte
- sample presenting
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- H—ELECTRICITY
- H01—ELECTRIC ELEMENTS
- H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
- H01J49/00—Particle spectrometers or separator tubes
- H01J49/02—Details
- H01J49/04—Arrangements for introducing or extracting samples to be analysed, e.g. vacuum locks; Arrangements for external adjustment of electron- or ion-optical components
- H01J49/0409—Sample holders or containers
- H01J49/0418—Sample holders or containers for laser desorption, e.g. matrix-assisted laser desorption/ionisation [MALDI] plates or surface enhanced laser desorption/ionisation [SELDI] plates
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N1/00—Sampling; Preparing specimens for investigation
- G01N1/28—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
- G01N1/40—Concentrating samples
- G01N1/405—Concentrating samples by adsorption or absorption
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6803—General methods of protein analysis not limited to specific proteins or families of proteins
- G01N33/6848—Methods of protein analysis involving mass spectrometry
- G01N33/6851—Methods of protein analysis involving laser desorption ionisation mass spectrometry
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T436/00—Chemistry: analytical and immunological testing
- Y10T436/24—Nuclear magnetic resonance, electron spin resonance or other spin effects or mass spectrometry
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T436/00—Chemistry: analytical and immunological testing
- Y10T436/25—Chemistry: analytical and immunological testing including sample preparation
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T436/00—Chemistry: analytical and immunological testing
- Y10T436/25—Chemistry: analytical and immunological testing including sample preparation
- Y10T436/25375—Liberation or purification of sample or separation of material from a sample [e.g., filtering, centrifuging, etc.]
- Y10T436/255—Liberation or purification of sample or separation of material from a sample [e.g., filtering, centrifuging, etc.] including use of a solid sorbent, semipermeable membrane, or liquid extraction
Abstract
A probe that is removably insertable into a mass spectrometer, the probe having a sample presenting surface for presenting an analyte to an energy source that emits energy capable of desorbing/ionizing the analyte from the probe for analyte detection, wherein said surface is derivatised with a non-crystalline layer of energy absorbing molecules which are capable of absorbing said energy to facilitate the desorption of an analyte presented thereon.
Claims (82)
1. A mass spectrometry probe comprising:
(a) a sample presenting surface;
(b) energy absorbing molecules associated with the sample presenting surface; and (c) an analyte which is not dispersed in a matrix crystalline structure, but is presented within, on or above the energy absorbing molecules, wherein the probe promotes desorption of substantially intact analyte molecules when the probe is exposed to laser energy.
(a) a sample presenting surface;
(b) energy absorbing molecules associated with the sample presenting surface; and (c) an analyte which is not dispersed in a matrix crystalline structure, but is presented within, on or above the energy absorbing molecules, wherein the probe promotes desorption of substantially intact analyte molecules when the probe is exposed to laser energy.
2. The probe of claim 1, wherein the sample presenting surface is derivatized with the energy absorbing molecules.
3. The probe of claim 1, wherein the energy absorbing molecules are covalently bound to the sample presenting surface.
4. The probe of claim 1, wherein the sample presenting surface is adhered to the probe magnetically.
5. The probe of claim 1, wherein the sample presenting surface comprises metal, metal coated with a synthetic polymer, glass, ceramic, a synthetic polymer or a mixture thereof.
6. The probe of claim 1, wherein the sample presenting surface comprises a synthetic polymer.
7. The probe of claim 6, wherein the energy absorbing molecules are comprised within the synthetic polymer.
8. The probe of claim 1, wherein the energy absorbing molecules are arranged in a predetermined array.
9. The probe of claim 1, wherein the analyte comprises a protein.
10. The probe of claim 1, wherein the analyte comprises a carbohydrate.
11. The probe of claim 1, wherein the analyte comprises a nucleic acid.
12. The probe of claim 11, wherein the nucleic acid is DNA.
13. The probe of any of claims 1-12, wherein the energy absorbing molecules are selected from the group consisting of dimethoxy hydroxycinnamic acid, cinnamamide, cinnamyl bromide, dihydroxybenzoic acid, and cyanohydroxycinnamic acid.
14. The probe of any of claims 1-12, wherein the sample presenting surface is a surface of the probe.
15. The probe of any of claims 1-12, wherein the sample presenting surface is a bead associated with the probe surface.
16. A method for promoting desorption of analytes in substantially intact form into the gas phase comprising:
(a) depositing an analyte on a sample presenting surface of a probe, wherein energy absorbing molecules are associated with the sample presenting surface and the analyte is not dispersed in a matrix crystalline structure, but is presented within, on or above the energy absorbing molecules wherein the probe promotes desorption of substantially intact analyte molecules when the probe is exposed to an energy source; and (b) exposing the probe to laser energy.
(a) depositing an analyte on a sample presenting surface of a probe, wherein energy absorbing molecules are associated with the sample presenting surface and the analyte is not dispersed in a matrix crystalline structure, but is presented within, on or above the energy absorbing molecules wherein the probe promotes desorption of substantially intact analyte molecules when the probe is exposed to an energy source; and (b) exposing the probe to laser energy.
17. The method of claim 16, wherein the sample presenting surface is derivatized with the energy absorbing molecules.
18. The method of claim 16, wherein the energy absorbing molecules are covalently bound to the sample presenting surface.
19. The method of claim 16, wherein the sample presenting surface is adhered to the probe magnetically.
20. The method of claim 16, wherein the sample presenting surface comprises metal, metal coated with a synthetic polymer, glass, ceramic, a synthetic polymer or a mixture thereof.
21. The method of claim 16, wherein the sample presenting surface comprises a synthetic polymer.
22. The method of claim 21, wherein the energy absorbing molecules are comprised within the synthetic polymer.
23. The method of claim 16, wherein the energy absorbing molecules are arranged in a predetermined array.
24. The method of claim 16, wherein the analyte is from a biological sample.
25. The method of claim 24, wherein the biological sample is selected from the group consisting of blood, tears, urine, saliva, gastrointestinal fluids, spinal fluid, amniotic fluid, bone marrow, bacteria, viruses, cells in culture, biopsy tissue, plant tissue or fluids and insect tissue or fluids.
26. The method of claim 16, wherein the analyte comprises a protein.
27. The method of claim 16, wherein the analyte comprises a carbohydrate.
28. The method of claim 16, wherein the analyte comprises a nucleic acid.
29. The method of claim 28, wherein the nucleic acid is DNA.
30. The method of any of claims 16-29, wherein the energy absorbing molecules are selected from the group consisting of dimethoxy hydroxycinnamic acid, cinnamamide, cinnamyl bromide, dihydroxybenzoic acid, and cyanohydroxycinnamic acid.
31. The method of any of claims 16-29, wherein the sample presenting surface is a surface of the probe.
32. The method of any of claims 16-29, wherein the sample presenting surface is a bead associated with the probe surface.
33. A mass spectrometry apparatus for promoting desorption of analytes in substantially intact form into the gas phase comprising:
(a) a probe for promoting desorption of analytes in substantially intact form into the gas phase comprising:
i. a sample presenting surface;
ii. energy absorbing molecules associated with the sample presenting surface; and iii. an analyte which is not dispersed in a matrix crystalline structure, but is presented within, on or above the energy absorbing molecules; wherein the probe promotes desorption of substantially intact analyte molecules when the probe is exposed to an energy source;
(b) an energy source that directs laser energy to the sample presenting surface for desorbing and ionizing the analyte; and (c) a detector that detects the desorbed, ionized analyte.
(a) a probe for promoting desorption of analytes in substantially intact form into the gas phase comprising:
i. a sample presenting surface;
ii. energy absorbing molecules associated with the sample presenting surface; and iii. an analyte which is not dispersed in a matrix crystalline structure, but is presented within, on or above the energy absorbing molecules; wherein the probe promotes desorption of substantially intact analyte molecules when the probe is exposed to an energy source;
(b) an energy source that directs laser energy to the sample presenting surface for desorbing and ionizing the analyte; and (c) a detector that detects the desorbed, ionized analyte.
34. The apparatus of claim 33, further comprising:
(d) a spectrometer tube into which ionized analyte is accelerated; and (e) means for applying an accelerating electrical potential to the desorbed, ionized analyte; wherein the mass spectrometer is a time-of-flight mass spectrometer.
(d) a spectrometer tube into which ionized analyte is accelerated; and (e) means for applying an accelerating electrical potential to the desorbed, ionized analyte; wherein the mass spectrometer is a time-of-flight mass spectrometer.
35. The apparatus of claim 34, further comprising:
(f) vacuum means for applying a vacuum to the interior of the tube.
(f) vacuum means for applying a vacuum to the interior of the tube.
36. The apparatus of claim 33, wherein the detector comprises an electron multiplier.
37. The apparatus of claim 33, wherein the sample presenting surface is derivatized with the energy absorbing molecules.
38. The apparatus of claim 33, wherein the energy absorbing molecules are covalently bound to the sample presenting surface.
39. The apparatus of claim 33, wherein the sample presenting surface is adhered to the probe magnetically.
40. The apparatus of claim 33, wherein the sample presenting surface comprises metal, metal coated with a synthetic polymer, glass, ceramic, a synthetic polymer or a mixture thereof.
41. The apparatus of claim 33, wherein the sample presenting surface comprises a synthetic polymer.
42. The apparatus of claim 41, wherein the energy absorbing molecules are comprised within the synthetic polymer.
43. The apparatus of claim 33, wherein the energy source is energy from a nitrogen laser.
44. The apparatus of claim 33, wherein the energy source is energy from an Nd-YAG laser.
45. The apparatus of claim 33, wherein the energy absorbing molecules axe arranged in a predetermined array.
46. The apparatus of claim 33, wherein the analyte comprises a protein.
47. The apparatus of claim 33, wherein the analyte comprises a carbohydrate.
48. The apparatus of claim 33, wherein the analyte comprises a nucleic acid.
49. The apparatus of claim 48, wherein the nucleic acid is DNA.
50. The apparatus of any of claims 33-49, wherein the energy absorbing molecules are selected from the group consisting of dimethoxy hydroxycinnamic acid, cinnamamide, cinnamyl bromide, dihydroxybenzoic acid, and cyanohydroxycinnamic acid.
51. The apparatus of any of claims 33-49, wherein the sample presenting surface is a surface of the probe.
52. The apparatus of any of claims 33-49, wherein the sample presenting surface is a bead associated with the probe surface.
53. A probe that is removably insertable into a mass spectrometer, the probe having a surface that is derivitized with a layer of energy absorbing molecules, wherein the energy absorbing molecules absorb energy from a laser energy source thereby enabling desorption of analyte molecules from the probe.
54. The probe of claim 53 wherein the energy absorbing molecules are noncovalently bound to the surface.
55. The probe of claim 53 wherein the energy absorbing molecules are covalently bound to the surface.
56. The probe of claim 54 or 55 wherein the energy absorbing molecules are selected from the group consisting of dimethoxy hydroxycinnamic acid, cinnamamide, cinnamyl bromide, dihydroxybenzoic acid and cyanohydroxycinnamic acid.
57. The probe of claim 54 or 55 wherein the probe is free of the analyte.
58. The probe of claim 54 or 55 further comprising the analyte deposited on the probe for presentation to the high energy source.
59. The probe of claim 54 or 55 wherein the layer comprises a plurality of different energy absorbing molecules.
60. The probe of claim 54 or 55 comprising a plurality of layers of different energy absorbing molecules.
61. The probe of claim 54 or 55 herein the surface is adhered to the probe magnetically.
62. The probe of claim 54 or 55 wherein the surface comprises metal, metal coated with a synthetic polymer, glass, ceramic, a synthetic polymer or a mixture thereof.
63. The probe of claim 54 or 55 wherein the surface is coated with a synthetic polymer.
64. The probe of claim 54 or 55 wherein the energy absorbing molecules are comprised in spots arranged in a predetermined array.
65. The probe of claim 62 wherein the energy absorbing molecules are comprised within the synthetic polymer.
66. The probe of claim 63 wherein the energy absorbing molecules are comprised within the synthetic polymer.
67. The probe of claim 64 wherein the array comprises an array of spots from 0.005 to 0.080 inches in diameter.
68. A mass spectrometry apparatus comprising:
(a) a probe comprising:
i. a sample presenting surface; and ii. a layer of energy absorbing molecules derivitized to the sample presenting surface; and (b) an energy source that directs laser energy to the sample presenting surface for desorbing and ionizing the analyte; and (c) a detector that detects the desorbed, ionized analyte.
(a) a probe comprising:
i. a sample presenting surface; and ii. a layer of energy absorbing molecules derivitized to the sample presenting surface; and (b) an energy source that directs laser energy to the sample presenting surface for desorbing and ionizing the analyte; and (c) a detector that detects the desorbed, ionized analyte.
69. The apparatus of claim 68, further comprising:
(d) a spectrometer tube into which ionized analyte is accelerated; and (e) means for applying an accelerating electrical potential to the desorbed, ionized analyte; wherein the mass spectrometer is a time-of-flight mass spectrometer.
(d) a spectrometer tube into which ionized analyte is accelerated; and (e) means for applying an accelerating electrical potential to the desorbed, ionized analyte; wherein the mass spectrometer is a time-of-flight mass spectrometer.
70. The apparatus of claim 69, further comprising:
(f) vacuum means for applying a vacuum to the interior of the tube.
(f) vacuum means for applying a vacuum to the interior of the tube.
71. The apparatus of claim 68, wherein the detector comprises an electron multiplier.
72. The apparatus of claim 68, wherein the energy absorbing molecules are covalently bound to the sample presenting surface.
73. The apparatus of claim 68, wherein the sample presenting surface is adhered to the probe magnetically.
74. The apparatus of claim 68, wherein the sample presenting surface comprises metal, metal coated with a synthetic polymer, glass, ceramic, a synthetic polymer or a mixture thereof.
75. The apparatus of claim 68, wherein the sample presenting surface comprises a synthetic polymer.
76. The apparatus of claim 75, wherein the energy absorbing molecules are comprised within the synthetic polymer.
77. The apparatus of claim 68, wherein the energy source is energy from a nitrogen laser.
78. The apparatus of claim 68, wherein the energy source is energy from an Nd-YAG laser.
79. The apparatus of claim 68, wherein the energy absorbing molecules are arranged in a predetermined array.
80. The apparatus of any of claims 68-79, wherein the energy absorbing molecules are selected from the group consisting of dimethoxy hydroxycinnamic acid, cinnamamide, cinnamyl bromide, dihydroxybenzoic acid, and cyanohydroxycinnamic acid.
81. The apparatus of any of claims 68-79, wherein the sample presenting surface is a surface of the probe.
82. The apparatus of any of claims 68-79, wherein the sample presenting surface is a bead associated with the probe surface.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US6889693A | 1993-05-28 | 1993-05-28 | |
US08/068,896 | 1993-05-28 | ||
CA002163426A CA2163426C (en) | 1993-05-28 | 1994-05-27 | Method and apparatus for desorption and ionization of analytes |
Related Parent Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CA002163426A Division CA2163426C (en) | 1993-05-28 | 1994-05-27 | Method and apparatus for desorption and ionization of analytes |
Publications (2)
Publication Number | Publication Date |
---|---|
CA2512290A1 true CA2512290A1 (en) | 1994-12-08 |
CA2512290C CA2512290C (en) | 2010-02-02 |
Family
ID=22085400
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CA002512290A Expired - Lifetime CA2512290C (en) | 1993-05-28 | 1994-05-27 | Method and apparatus for desorption and ionization of analytes |
CA002163426A Expired - Lifetime CA2163426C (en) | 1993-05-28 | 1994-05-27 | Method and apparatus for desorption and ionization of analytes |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CA002163426A Expired - Lifetime CA2163426C (en) | 1993-05-28 | 1994-05-27 | Method and apparatus for desorption and ionization of analytes |
Country Status (12)
Country | Link |
---|---|
US (9) | US5719060A (en) |
EP (2) | EP0700521B1 (en) |
JP (3) | JP3639594B2 (en) |
AT (1) | ATE242485T1 (en) |
AU (1) | AU676582B2 (en) |
CA (2) | CA2512290C (en) |
DE (1) | DE69432791T2 (en) |
DK (1) | DK0700521T3 (en) |
ES (1) | ES2201077T3 (en) |
NZ (1) | NZ267842A (en) |
PT (1) | PT700521E (en) |
WO (1) | WO1994028418A1 (en) |
Families Citing this family (416)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPH07507394A (en) * | 1992-05-29 | 1995-08-10 | ザ ロックフェラー ユニバーシティ | Methods and materials for peptide sequencing using a mass spectrometer |
US6436635B1 (en) * | 1992-11-06 | 2002-08-20 | Boston University | Solid phase sequencing of double-stranded nucleic acids |
US5605798A (en) * | 1993-01-07 | 1997-02-25 | Sequenom, Inc. | DNA diagnostic based on mass spectrometry |
US20020037517A1 (en) * | 1993-05-28 | 2002-03-28 | Hutchens T. William | Methods for sequencing biopolymers |
NZ267842A (en) * | 1993-05-28 | 1997-09-22 | Baylor College Medicine | Apparatus for measuring molecular mass (by mass spectrometry) in which the sample is ionised on the sample holder and desorbed therefrom by laser pulses |
US6071610A (en) | 1993-11-12 | 2000-06-06 | Waters Investments Limited | Enhanced resolution matrix-laser desorption and ionization TOF-MS sample surface |
US7803529B1 (en) * | 1995-04-11 | 2010-09-28 | Sequenom, Inc. | Solid phase sequencing of biopolymers |
US20060063193A1 (en) * | 1995-04-11 | 2006-03-23 | Dong-Jing Fu | Solid phase sequencing of double-stranded nucleic acids |
US20020164818A1 (en) * | 1995-05-23 | 2002-11-07 | Gruber Karl F. | Mass spectrometric immunoassay analysis of specific proteins and variants present in various biological fluids |
US20030027216A1 (en) * | 2001-07-02 | 2003-02-06 | Kiernan Urban A. | Analysis of proteins from biological fluids using mass spectrometric immunoassay |
WO1996037777A1 (en) * | 1995-05-23 | 1996-11-28 | Nelson Randall W | Mass spectrometric immunoassay |
US6316266B1 (en) * | 1995-06-07 | 2001-11-13 | Arizona State University Board Of Regents | Sample presentation apparatus for mass spectrometry |
ATE305969T1 (en) * | 1995-06-07 | 2005-10-15 | Univ Arizona | SAMPLER FOR MASS SPECTROMETRY |
AU756020B2 (en) * | 1995-06-07 | 2003-01-02 | Arizona Board Of Regents, The | A sample presentation apparatus for mass spectrometry |
US6004770A (en) * | 1995-06-07 | 1999-12-21 | Arizona State University Board Of Regents | Sample presentation apparatus for mass spectrometry |
US6093541A (en) * | 1995-06-07 | 2000-07-25 | Arizona State University Board Of Regents | Mass spectrometer having a derivatized sample presentation apparatus |
GB9518429D0 (en) * | 1995-09-08 | 1995-11-08 | Pharmacia Biosensor | A rapid method for providing kinetic and structural data in molecular interaction analysis |
WO1997012989A1 (en) | 1995-10-02 | 1997-04-10 | Katoot Mohammad W | Biologically-active polymers |
US5716825A (en) * | 1995-11-01 | 1998-02-10 | Hewlett Packard Company | Integrated nucleic acid analysis system for MALDI-TOF MS |
US5705813A (en) * | 1995-11-01 | 1998-01-06 | Hewlett-Packard Company | Integrated planar liquid handling system for maldi-TOF MS |
US6312893B1 (en) | 1996-01-23 | 2001-11-06 | Qiagen Genomics, Inc. | Methods and compositions for determining the sequence of nucleic acid molecules |
US6613508B1 (en) | 1996-01-23 | 2003-09-02 | Qiagen Genomics, Inc. | Methods and compositions for analyzing nucleic acid molecules utilizing sizing techniques |
US6027890A (en) * | 1996-01-23 | 2000-02-22 | Rapigene, Inc. | Methods and compositions for enhancing sensitivity in the analysis of biological-based assays |
SE9602545L (en) * | 1996-06-25 | 1997-12-26 | Michael Mecklenburg | Method of discriminating complex biological samples |
US6024925A (en) | 1997-01-23 | 2000-02-15 | Sequenom, Inc. | Systems and methods for preparing low volume analyte array elements |
ATE259056T1 (en) | 1996-11-06 | 2004-02-15 | Sequenom Inc | METHOD FOR MASS SPECTROMETRY |
US7285422B1 (en) * | 1997-01-23 | 2007-10-23 | Sequenom, Inc. | Systems and methods for preparing and analyzing low volume analyte array elements |
EP0881494A1 (en) * | 1997-04-29 | 1998-12-02 | Roche Diagnostics GmbH | Method of simultaneous determination of proteins and their derivatives |
WO1998053296A1 (en) * | 1997-05-19 | 1998-11-26 | Charles Evans And Associates | Analysis of molecules bound to solid surfaces using selective bond cleavage processes |
AU2002301047B2 (en) * | 1997-06-20 | 2005-11-10 | Ciphergen Biosystems, Inc. | Retentate Chromatography And Protein Chip Arrays With Applications In Biology And Medicine |
NZ516848A (en) | 1997-06-20 | 2004-03-26 | Ciphergen Biosystems Inc | Retentate chromatography apparatus with applications in biology and medicine |
AU2003235062B2 (en) * | 1997-06-20 | 2006-02-02 | Ciphergen Biosystems, Inc. | Retentate chromatography and protein chip arrays with applications in biology and medicine |
EP1387390B1 (en) | 1997-06-20 | 2009-02-18 | Bio - Rad Laboratories, Inc. | Retentate chromatography and protein chip arrays with applications in biology and medicine |
US6207370B1 (en) * | 1997-09-02 | 2001-03-27 | Sequenom, Inc. | Diagnostics based on mass spectrometric detection of translated target polypeptides |
US5952654A (en) * | 1997-10-29 | 1999-09-14 | Northeastern University | Field-release mass spectrometry |
JP2002502977A (en) | 1998-02-04 | 2002-01-29 | インビトロジェン コーポレイション | Microarrays and their uses |
US6849847B1 (en) | 1998-06-12 | 2005-02-01 | Agilent Technologies, Inc. | Ambient pressure matrix-assisted laser desorption ionization (MALDI) apparatus and method of analysis |
US6221626B1 (en) | 1998-06-30 | 2001-04-24 | University Of Geneva | Kit for electroblotting polypeptides separated on an electrophoresis gel |
US6780582B1 (en) * | 1998-07-14 | 2004-08-24 | Zyomyx, Inc. | Arrays of protein-capture agents and methods of use thereof |
US6576478B1 (en) * | 1998-07-14 | 2003-06-10 | Zyomyx, Inc. | Microdevices for high-throughput screening of biomolecules |
US6406921B1 (en) | 1998-07-14 | 2002-06-18 | Zyomyx, Incorporated | Protein arrays for high-throughput screening |
US6897073B2 (en) * | 1998-07-14 | 2005-05-24 | Zyomyx, Inc. | Non-specific binding resistant protein arrays and methods for making the same |
US6682942B1 (en) | 1998-07-14 | 2004-01-27 | Zyomyx, Inc. | Microdevices for screening biomolecules |
US20020119579A1 (en) * | 1998-07-14 | 2002-08-29 | Peter Wagner | Arrays devices and methods of use thereof |
US6206840B1 (en) * | 1998-08-12 | 2001-03-27 | Siemens Aktiengesellschaft | Method for the identification of a liquid secreted by a living subject particularly for identification of amniotic fluid |
GB9821393D0 (en) * | 1998-10-01 | 1998-11-25 | Brax Genomics Ltd | Protein profiling 2 |
US20060172925A1 (en) * | 1998-10-26 | 2006-08-03 | Board Of Regents, The University Of Texas System | Thio-siRNA aptamers |
US20040242521A1 (en) * | 1999-10-25 | 2004-12-02 | Board Of Regents, The University Of Texas System | Thio-siRNA aptamers |
US6423493B1 (en) * | 1998-10-26 | 2002-07-23 | Board Of Regents The University Of Texas System | Combinatorial selection of oligonucleotide aptamers |
ATE268903T1 (en) * | 1999-01-28 | 2004-06-15 | Univ Geneve | METHOD AND DEVICE FOR IDENTIFYING OR CHARACTERIZING POLYPEPTIDES |
ATE556149T1 (en) * | 1999-02-23 | 2012-05-15 | Caliper Life Sciences Inc | MANIPULATION OF MICROPARTICLES IN MICROFLUIDIC SYSTEMS |
US6288390B1 (en) * | 1999-03-09 | 2001-09-11 | Scripps Research Institute | Desorption/ionization of analytes from porous light-absorbing semiconductor |
EP1173878B1 (en) | 1999-04-27 | 2011-04-06 | Bio-Rad Laboratories, Inc. | Probes for a gas phase ion spectrometer |
KR20020022653A (en) | 1999-04-29 | 2002-03-27 | 사이퍼젠 바이오시스템스, 인코오포레이티드 | Sample holder with hydrophobic coating for gas phase mass spectrometers |
DK2067788T3 (en) | 1999-05-18 | 2015-10-19 | Dyax Corp | Fab fragment libraries and methods for using them |
WO2000077812A2 (en) * | 1999-06-10 | 2000-12-21 | Northeastern University | Light-induced electron capture at a surface |
US20090233806A1 (en) * | 1999-07-06 | 2009-09-17 | Carr Francis J | Protein isolation and analysis |
US7138254B2 (en) | 1999-08-02 | 2006-11-21 | Ge Healthcare (Sv) Corp. | Methods and apparatus for performing submicroliter reactions with nucleic acids or proteins |
EP1216406A4 (en) * | 1999-08-27 | 2007-02-07 | Large Scale Proteomics Corp | Devices for use in maldi mass spectrometry |
US6869572B1 (en) | 1999-09-13 | 2005-03-22 | Millipore Corporation | High density cast-in-place sample preparation card |
JP4014767B2 (en) * | 1999-09-17 | 2007-11-28 | 富士フイルム株式会社 | Rigid macro array |
US7167615B1 (en) | 1999-11-05 | 2007-01-23 | Board Of Regents, The University Of Texas System | Resonant waveguide-grating filters and sensors and methods for making and using same |
US6936424B1 (en) * | 1999-11-16 | 2005-08-30 | Matritech, Inc. | Materials and methods for detection and treatment of breast cancer |
WO2001046458A1 (en) * | 1999-12-20 | 2001-06-28 | The Penn State Research Foundation | Deposited thin films and their use in detection, attachment, and bio-medical applications |
US20030087265A1 (en) * | 2000-01-21 | 2003-05-08 | Edward Sauter | Specific microarrays for breast cancer screening |
CN1444646A (en) | 2000-02-23 | 2003-09-24 | 齐翁米克斯股份有限公司 | Chips having elevated sample surfaces |
US7351540B1 (en) * | 2000-03-17 | 2008-04-01 | Merck Patent Gmbh | Protein isolation and analysis |
CA2301451A1 (en) * | 2000-03-20 | 2001-09-21 | Thang T. Pham | Method for analysis of analytes by mass spectrometry |
US7122790B2 (en) * | 2000-05-30 | 2006-10-17 | The Penn State Research Foundation | Matrix-free desorption ionization mass spectrometry using tailored morphology layer devices |
NZ522859A (en) * | 2000-06-19 | 2005-08-26 | Correlogic Systems Inc | Heuristic method of classifying objects using a vector space having multiple preclassified data clusters |
AU2001278872A1 (en) * | 2000-07-06 | 2002-01-21 | Genvec, Inc. | Method of identifying a binding partner of a gene product |
KR101054732B1 (en) * | 2000-07-18 | 2011-08-05 | 더 유나이티드 스테이츠 오브 아메리카 애즈 리프리젠티드 바이 더 세크레터리 오브 더 디파트먼트 오브 헬쓰 앤드 휴먼 써비시즈 | How to Identify Biological Conditions Based on Hidden Patterns of Biological Data |
DE60107022T2 (en) | 2000-07-24 | 2005-11-24 | Health Research Inc. | Method for the detection of prostate-specific membrane antigen in serum |
DE10043042C2 (en) * | 2000-09-01 | 2003-04-17 | Bruker Daltonik Gmbh | Method for loading a sample carrier with biomolecules for mass spectrometric analysis |
JP4706093B2 (en) * | 2000-09-25 | 2011-06-22 | 富士レビオ株式会社 | Method for removing and purifying parvovirus |
WO2002031484A2 (en) * | 2000-10-11 | 2002-04-18 | Ciphergen Biosystems, Inc. | Methods for characterizing molecular interactions using affinity capture tandem mass spectrometry |
US20020142483A1 (en) | 2000-10-30 | 2002-10-03 | Sequenom, Inc. | Method and apparatus for delivery of submicroliter volumes onto a substrate |
US7407773B2 (en) * | 2000-11-03 | 2008-08-05 | Procognia, Ltd. | Method for characterizing a carbohydrate polymer |
US7326563B2 (en) | 2000-11-08 | 2008-02-05 | Surface Logix, Inc. | Device and method for monitoring leukocyte migration |
US6699665B1 (en) | 2000-11-08 | 2004-03-02 | Surface Logix, Inc. | Multiple array system for integrating bioarrays |
US6893851B2 (en) | 2000-11-08 | 2005-05-17 | Surface Logix, Inc. | Method for arraying biomolecules and for monitoring cell motility in real-time |
US7374906B2 (en) | 2000-11-08 | 2008-05-20 | Surface Logix, Inc. | Biological assays using gradients formed in microfluidic systems |
US6844184B2 (en) * | 2000-11-08 | 2005-01-18 | Surface Logix, Inc. | Device for arraying biomolecules and for monitoring cell motility in real-time |
US7033821B2 (en) * | 2000-11-08 | 2006-04-25 | Surface Logix, Inc. | Device for monitoring cell motility in real-time |
US6864065B2 (en) * | 2000-11-08 | 2005-03-08 | Surface Logix, Inc. | Assays for monitoring cell motility in real-time |
US7033819B2 (en) | 2000-11-08 | 2006-04-25 | Surface Logix, Inc. | System for monitoring cell motility in real-time |
US20030129666A1 (en) * | 2001-01-09 | 2003-07-10 | Mitsubishi Pharma Corporation | Novel proteome analysis method and devices therefor |
US20060051741A1 (en) | 2002-10-04 | 2006-03-09 | Protosera Inc. | Plate for mass spectrometry, process for preparing the same and use thereof |
JP2002228668A (en) * | 2001-01-31 | 2002-08-14 | Shimadzu Corp | Automatic sampler |
KR20030074773A (en) * | 2001-02-01 | 2003-09-19 | 싸이퍼젠 바이오시스템즈, 인코포레이티드 | Improved methods for protein identification, characterization and sequencing by tandem mass spectrometry |
WO2002064621A2 (en) * | 2001-02-14 | 2002-08-22 | Attenuon, Llc | Histidine proline rich glycoprotein (hprg) as an anti-angiogenic and anti-tumor agent |
EP1370867B1 (en) * | 2001-03-02 | 2010-08-04 | Activx Biosciences, Inc. | Protein profiling platform |
US20030228639A1 (en) * | 2001-03-19 | 2003-12-11 | Wright George L | Prostate cancer markers |
US20030219734A1 (en) * | 2001-04-13 | 2003-11-27 | Biosite Incorporated | Polypeptides related to natriuretic peptides and methods of their identification and use |
US7524635B2 (en) * | 2003-04-17 | 2009-04-28 | Biosite Incorporated | Methods and compositions for measuring natriuretic peptides and uses thereof |
US6804410B2 (en) | 2001-04-17 | 2004-10-12 | Large Scale Proteomics Corporation | System for optimizing alignment of laser beam with selected points on samples in MALDI mass spectrometer |
US20030077616A1 (en) * | 2001-04-19 | 2003-04-24 | Ciphergen Biosystems, Inc. | Biomolecule characterization using mass spectrometry and affinity tags |
US20020155587A1 (en) | 2001-04-20 | 2002-10-24 | Sequenom, Inc. | System and method for testing a biological sample |
US6825032B2 (en) | 2001-05-14 | 2004-11-30 | Sigma-Aldrich Co. | High capacity assay platforms |
EP1395824A1 (en) * | 2001-05-14 | 2004-03-10 | The Penn State Research Foundation | Matrix-free desorption ionization mass spectrometry using tailored morphology layer devices |
JP4015992B2 (en) * | 2001-05-25 | 2007-11-28 | ウォーターズ・インヴェストメンツ・リミテッド | Sample concentration MALDI plate for MALDI mass spectrometer |
JP4194370B2 (en) * | 2001-05-25 | 2008-12-10 | ウォーターズ・インヴェストメンツ・リミテッド | Desalting plate for MALDI mass spectrometry |
JP4264002B2 (en) * | 2001-07-17 | 2009-05-13 | バイオ−ラド ラボラトリーズ インコーポレイテッド | Latex-based adsorption chip |
GB0120131D0 (en) * | 2001-08-17 | 2001-10-10 | Micromass Ltd | Maldi target plate |
WO2004072616A2 (en) * | 2003-02-10 | 2004-08-26 | Waters Investments Limited | A sample preparation plate for mass spectrometry |
WO2003018797A2 (en) * | 2001-08-22 | 2003-03-06 | Helix Biopharma Corporation | Method and device for integrated protein expression, purification and detection |
WO2003019193A1 (en) * | 2001-08-30 | 2003-03-06 | Ciphergen Biosystems, Inc. | Method of diagnosing nephrotic syndrome |
US20040043436A1 (en) * | 2001-09-21 | 2004-03-04 | Antonia Vlahou | Biomarkers of transitional cell carcinoma of the bladder |
US7842498B2 (en) * | 2001-11-08 | 2010-11-30 | Bio-Rad Laboratories, Inc. | Hydrophobic surface chip |
US20030091976A1 (en) * | 2001-11-14 | 2003-05-15 | Ciphergen Biosystems, Inc. | Methods for monitoring polypeptide production and purification using surface enhanced laser desorption/ionization mass spectrometry |
US20030162190A1 (en) * | 2001-11-15 | 2003-08-28 | Gorenstein David G. | Phosphoromonothioate and phosphorodithioate oligonucleotide aptamer chip for functional proteomics |
US20040018519A1 (en) * | 2001-11-16 | 2004-01-29 | Wright ,Jr. George L | Methods and devices for quantitative detection of prostate specific membrane antigen and other prostatic markers |
US6946653B2 (en) | 2001-11-27 | 2005-09-20 | Ciphergen Biosystems, Inc. | Methods and apparatus for improved laser desorption ionization tandem mass spectrometry |
AU2002358219A1 (en) * | 2001-12-21 | 2003-07-15 | Sense Proteomic Limited | Protein analysis using mass spectrometry |
US7276381B2 (en) * | 2002-01-25 | 2007-10-02 | Bio-Rad Laboratories, Inc. | Monomers and polymers having energy absorbing moieties of use in desorption/ionization of analytes |
US20030207462A1 (en) * | 2002-01-25 | 2003-11-06 | Ciphergen Biosystems, Inc. | Monomers and polymers having energy absorbing moieties of use in desorption/ionization of analytes |
AU2003211157A1 (en) * | 2002-02-21 | 2003-09-09 | Eastern Virginia Medical School | Protein biomarkers that distinguish prostate cancer from non-malignant cells |
US20090149335A1 (en) * | 2002-02-22 | 2009-06-11 | Biolife Solutions Inc. | Method and use of microarray technology and proteogenomic analysis to predict efficacy of human and xenographic cell, tissue and organ transplant |
US20030232396A1 (en) * | 2002-02-22 | 2003-12-18 | Biolife Solutions, Inc. | Method and use of protein microarray technology and proteomic analysis to determine efficacy of human and xenographic cell, tissue and organ transplant |
WO2003074571A2 (en) * | 2002-02-28 | 2003-09-12 | Keck Graduate Institute | Cationic polyelectrolytes in biomolecule purification and analysis |
US9870907B2 (en) * | 2002-03-11 | 2018-01-16 | Jp Scientific Limited | Probe for extraction of molecules of interest from a sample |
US20090026122A1 (en) | 2002-03-11 | 2009-01-29 | Janusz | Biocompatible solid-phase microextraction coatings and methods for their preparation |
US9733234B2 (en) | 2002-03-11 | 2017-08-15 | Jp Scientific Limited | Probe for extraction of molecules of interest from a sample |
AU2003226279A1 (en) * | 2002-04-08 | 2003-10-27 | Ciphergen Biosystems, Inc. | Serum biomarkers in hepatocellular carcinoma |
AUPS177202A0 (en) * | 2002-04-16 | 2002-05-23 | Diakyne Pty Ltd | Multi-element screening of trace elements |
EP1508042A4 (en) * | 2002-05-02 | 2008-04-02 | Bio Rad Laboratories | Biochips with surfaces coated with polysaccharide based hydrogels |
JP2006509186A (en) * | 2002-05-10 | 2006-03-16 | イースタン バージニア メディカル スクール | Prostate cancer biomarker |
US20040033613A1 (en) * | 2002-05-30 | 2004-02-19 | Zwick Michael G. | Saliva-based protein profiling |
WO2003101394A2 (en) * | 2002-05-31 | 2003-12-11 | Ciphergen Biosystems, Inc. | Defensins: use as antiviral agents |
US7109038B2 (en) * | 2002-06-13 | 2006-09-19 | The Johns Hopkins University | Occult blood detection in biological samples by laser desorption and matrix-assisted laser desorption/ionization mass spectrometry for biomedical applications |
US7348184B2 (en) * | 2002-07-24 | 2008-03-25 | Bio-Rad Laboratories, Inc. | Protein interaction difference mapping |
AU2003304161A1 (en) | 2002-07-29 | 2005-01-21 | Correlogic Systems, Inc. | Quality assurance/quality control for high throughput bioassay process |
US6624409B1 (en) | 2002-07-30 | 2003-09-23 | Agilent Technologies, Inc. | Matrix assisted laser desorption substrates for biological and reactive samples |
AU2003257109A1 (en) * | 2002-08-05 | 2004-02-23 | Invitrogen Corporation | Compositions and methods for molecular biology |
US20040153249A1 (en) * | 2002-08-06 | 2004-08-05 | The Johns Hopkins University | System, software and methods for biomarker identification |
ATE468534T1 (en) * | 2002-08-06 | 2010-06-15 | Univ Johns Hopkins | USE OF BIOMARKERS FOR DETECTING Ovarian CANCER |
AU2003263853A1 (en) * | 2002-08-16 | 2004-03-03 | Board Of Regents The University Of Texas System | Compositions and methods related to flavivirus envelope protein domain iii antigens |
US20050233473A1 (en) * | 2002-08-16 | 2005-10-20 | Zyomyx, Inc. | Methods and reagents for surface functionalization |
US20030119063A1 (en) * | 2002-09-03 | 2003-06-26 | Pham Thang T. | High accuracy protein identification |
US20040050787A1 (en) * | 2002-09-13 | 2004-03-18 | Elena Chernokalskaya | Apparatus and method for sample preparation and direct spotting eluants onto a MALDI-TOF target |
US7144743B2 (en) * | 2002-09-13 | 2006-12-05 | Pall Corporation | Preparation and use of mixed mode solid substrates for chromatography adsorbents and biochip arrays |
US7045366B2 (en) * | 2003-09-12 | 2006-05-16 | Ciphergen Biosystems, Inc. | Photocrosslinked hydrogel blend surface coatings |
US20060292701A1 (en) * | 2002-09-13 | 2006-12-28 | Ciphergen Biosystems Inc. | Photocrosslinked hydrogel blend surface coatings |
EP1572978A4 (en) * | 2002-10-16 | 2006-05-24 | Univ Texas | Bead bound combinatorial oligonucleoside phosphorothioate and phosphorodithioate aptamer libraries |
US7122384B2 (en) * | 2002-11-06 | 2006-10-17 | E. I. Du Pont De Nemours And Company | Resonant light scattering microparticle methods |
EP1590469A4 (en) | 2002-11-12 | 2005-12-28 | Becton Dickinson Co | Diagnosis of sepsis or sirs using biomarker profiles |
AU2003291483A1 (en) | 2002-11-12 | 2004-06-03 | Becton, Dickinson And Company | Diagnosis of sepsis or sirs using biomarker profiles |
US20040241775A1 (en) * | 2002-11-14 | 2004-12-02 | The Govt. Of The Usa As Represented By The Secretary Of The Dept. Of Health & Human Services | Methods and kits for determining risk of pre-term delivery |
US7105809B2 (en) * | 2002-11-18 | 2006-09-12 | 3M Innovative Properties Company | Microstructured polymeric substrate |
US7846748B2 (en) * | 2002-12-02 | 2010-12-07 | The University Of North Carolina At Chapel Hill | Methods of quantitation and identification of peptides and proteins |
EP1573044A4 (en) | 2002-12-18 | 2006-07-05 | Ciphergen Biosystems Inc | Serum biomarkers in lung cancer |
WO2004057940A2 (en) * | 2002-12-31 | 2004-07-15 | Pharmacia & Upjohn Company Llc | Canine dioxin/aryl hydrocarbon receptor sequences |
AU2003285724A1 (en) * | 2002-12-31 | 2004-07-22 | Pharmacia & Upjohn Company Llc | Canine l-pbe sequences |
WO2004058957A2 (en) * | 2002-12-31 | 2004-07-15 | Pharmacia & Upjohn Company Llc | Canine cyp1a2 sequences |
US20170212128A1 (en) | 2004-01-13 | 2017-07-27 | Tianxin Wang | Methods and compositions for mass spectrometry analysis |
US8119416B2 (en) * | 2004-01-13 | 2012-02-21 | Wuxi WeiYi Zhinengkeji, Inc. | MALDI analysis using modified matrices with affinity groups for non-covalent binding with analytes |
GB2425836B (en) * | 2003-02-10 | 2008-05-21 | Waters Investments Ltd | Adsorption, detection, and identification of components of ambient air with desorption/ionization on silicon mass spectrometry (dios-ms) |
WO2004073492A2 (en) * | 2003-02-14 | 2004-09-02 | Massachusetts Eye And Ear Infirmary | Chlamydia pneumoniae associated chronic intraocular disorders and treatment thereof |
DE10311384A1 (en) * | 2003-03-11 | 2004-09-30 | Universität Potsdam | Detection method for plant molecules |
US20040185448A1 (en) * | 2003-03-20 | 2004-09-23 | Viorica Lopez-Avila | Methods and devices for performing matrix assisted laser desorption/lonization protocols |
US6977370B1 (en) * | 2003-04-07 | 2005-12-20 | Ciphergen Biosystems, Inc. | Off-resonance mid-IR laser desorption ionization |
US20050233390A1 (en) * | 2003-04-09 | 2005-10-20 | Allen John W | Device including a proteinaceous factor, a recombinant proteinaceous factor, and a nucleotide sequence encoding the proteinaceous factor |
WO2004094460A2 (en) | 2003-04-17 | 2004-11-04 | Ciphergen Biosystems, Inc. | Polypeptides related to natriuretic peptides and methods of their identification and use |
WO2004094989A2 (en) * | 2003-04-22 | 2004-11-04 | Ciphergen Biosystems, Inc. | Methods of host cell protein analysis |
WO2004097368A2 (en) * | 2003-04-28 | 2004-11-11 | Ciphergen Biosystems, Inc. | Improved immunoassays |
US7138625B2 (en) * | 2003-05-02 | 2006-11-21 | Agilent Technologies, Inc. | User customizable plate handling for MALDI mass spectrometry |
WO2004103155A2 (en) * | 2003-05-16 | 2004-12-02 | Ciphergen Biosystems, Inc. | Surface-enhanced laser desorption/ionization-based disease diagnosis |
WO2005037053A2 (en) * | 2003-05-23 | 2005-04-28 | Board Of Regents - The University Of Texas System | High throughput screening of aptamer libraries for specific binding to proteins on viruses and other pathogens |
US7910523B2 (en) * | 2003-05-23 | 2011-03-22 | Board Of Regents, The University Of Texas System | Structure based and combinatorially selected oligonucleoside phosphorothioate and phosphorodithioate aptamer targeting AP-1 transcription factors |
US20060257946A1 (en) * | 2003-06-06 | 2006-11-16 | Ciphergen Biosystems, Inc | Serum biomarkers in ischaemic heart disease |
WO2005017487A2 (en) * | 2003-06-09 | 2005-02-24 | The Regents Of The University Of California | Matrix for maldi analysis based on porous polymer monoliths |
US20050100967A1 (en) * | 2003-07-11 | 2005-05-12 | Science & Technology Corporation @ Unm | Detection of endometrial pathology |
US20050032113A1 (en) * | 2003-07-17 | 2005-02-10 | Mitsubishi Pharma Corporation | Membrane protein library for proteome analysis and method for preparing same |
WO2005010016A2 (en) * | 2003-07-24 | 2005-02-03 | Board Of Regents | Thioaptamers enable discovery of physiological pathways and new therapeutic strategies |
WO2005011474A2 (en) * | 2003-08-01 | 2005-02-10 | Correlogic Systems, Inc. | Multiple high-resolution serum proteomic features for ovarian cancer detection |
US6977143B1 (en) * | 2003-09-08 | 2005-12-20 | Quest Diagnostics Investments Incorporated | Determination of testosterone by mass spectrometry |
US20050079631A1 (en) * | 2003-10-09 | 2005-04-14 | Science & Engineering Services, Inc. | Method and apparatus for ionization of a sample at atmospheric pressure using a laser |
US20050112650A1 (en) * | 2003-10-20 | 2005-05-26 | Ciphergen Biosystems, Inc. | Reactive polyurethane-based polymers |
US7858071B2 (en) * | 2003-10-23 | 2010-12-28 | University of Pittsburgh—of the Commonwealth System of Higher Education | Biomarkers for amyotrophic lateral sclerosis |
JP4796967B2 (en) | 2003-11-07 | 2011-10-19 | ヴァーミリオン インコーポレイテッド | Biomarkers for Alzheimer's disease |
WO2005055812A2 (en) | 2003-12-05 | 2005-06-23 | Ciphergen Biosystems, Inc. | Serum biomarkers for chagas disease |
WO2005059563A2 (en) * | 2003-12-18 | 2005-06-30 | Procognia Ltd. | Method for analyzing a glycomolecule |
WO2005061532A1 (en) * | 2003-12-23 | 2005-07-07 | Berthet Francois Xavier | Pathogenic infection detection compositions and methods |
US7183544B2 (en) * | 2003-12-31 | 2007-02-27 | Ciphergen Biosystems Inc. | Bi-functional polymer chip |
US20050181398A1 (en) * | 2004-01-16 | 2005-08-18 | Fung Eric T. | Specific detection of host response protein clusters |
EP1715948B1 (en) * | 2004-01-20 | 2016-11-23 | Pall Corporation | Chromatographic material for the absorption of proteins at physiological ionic strength |
US20050181513A1 (en) * | 2004-02-18 | 2005-08-18 | Viorica Lopez-Avila | Methods and compositions for assessing a sample by MAILDI mass spectrometry |
US20050233400A1 (en) * | 2004-03-03 | 2005-10-20 | Weiner Carl P | Proteomic method for predicting success of rescue cerclage |
US20060275923A1 (en) * | 2004-03-23 | 2006-12-07 | Hammond David J | Methods for reducing the range in concentrations of analyte species in a sample |
EP1580559B1 (en) * | 2004-03-23 | 2013-12-25 | Bio-Rad Laboratories, Inc. | Methods for reducing the variance between analyte concentrations taken from complex sample mixtures |
EP2207033B1 (en) | 2004-04-15 | 2014-06-18 | University of Florida Research Foundation, Inc. | Neural proteins as biomarkers for nervous system injury and other neural disorders |
US20050239134A1 (en) * | 2004-04-21 | 2005-10-27 | Board Of Regents, The University Of Texas System | Combinatorial selection of phosphorothioate single-stranded DNA aptamers for TGF-beta-1 protein |
WO2005107796A2 (en) | 2004-04-23 | 2005-11-17 | Pharmacia & Upjohn Company, Llc | Cellular permissivity factor for viruses, and uses thereof |
WO2005103281A2 (en) | 2004-04-26 | 2005-11-03 | Children's Medical Center Corporation | Platelet biomarkers for the detection of disease |
US20060023808A1 (en) * | 2004-05-17 | 2006-02-02 | Hajivandi Mahbod R | Compositions, kits, and methods for calibration in mass spectrometry |
WO2005118129A1 (en) * | 2004-05-27 | 2005-12-15 | Stratos Biosystems, Llc | Solid-phase affinity-based method for preparing and manipulating an analyte-containing solution |
US20060024725A1 (en) | 2004-07-30 | 2006-02-02 | Robert Hussa | Oncofetal fibronectin as a marker for pregnancy-related indications |
US7786261B2 (en) * | 2004-09-02 | 2010-08-31 | National Research Council Of Canada | Coiled-coil fusion proteins comprising cell receptor domains |
CA2480549A1 (en) | 2004-09-15 | 2006-03-15 | Phytronix Technologies Inc. | Ionization source for mass spectrometer |
WO2006118595A2 (en) * | 2004-09-17 | 2006-11-09 | Nanosys, Inc. | Nanostructured thin films and their uses |
WO2006034278A2 (en) * | 2004-09-21 | 2006-03-30 | Matritech, Inc. | Methods and compositions for detecting cancer using components of the u2 spliceosomal particle |
EP1802961A4 (en) * | 2004-09-29 | 2007-11-14 | Bio Rad Laboratories | Host-guest enery-absorbing complex |
WO2006047417A2 (en) | 2004-10-21 | 2006-05-04 | University Of Florida Research Foundation, Inc. | Detection of cannabinoid receptor biomarkers and uses thereof |
JP4636859B2 (en) | 2004-11-25 | 2011-02-23 | キヤノン株式会社 | Information acquisition method |
US7572596B2 (en) * | 2004-12-02 | 2009-08-11 | University Of Pittsburgh Of The Commonwealth System Of Higher Education | Modulation of the neuroendoctrine system as a therapy for motor neuron disease |
WO2006060799A2 (en) * | 2004-12-02 | 2006-06-08 | University Of Pittsburgh - Of The Commonwealth System Of Higher Education | Protein biomarkers and therapeutic targets in an animal model for amyotrophic lateral sclerosis |
US20080003599A1 (en) * | 2004-12-28 | 2008-01-03 | Dary Ekaterina L | Biological Microchip for Multiple Parallel Immunoassay of Compounds and Immunoassay Metods Using Said Microchip |
WO2006074360A2 (en) * | 2005-01-06 | 2006-07-13 | Eastern Virginia Medical School | Apolipoprotein a-ii isoform as a biomarker for prostate cancer |
CA2595377A1 (en) | 2005-01-28 | 2006-08-03 | Children's Medical Center Corporation | Methods for diagnosis and prognosis of epithelial cancers |
JP2008530555A (en) * | 2005-02-09 | 2008-08-07 | コレロジック システムズ,インコーポレイテッド | Identification of bacteria and spores |
US20060183863A1 (en) * | 2005-02-14 | 2006-08-17 | Ciphergen Biosystems, Inc. | Zwitterionic polymers |
JP2008538112A (en) * | 2005-03-23 | 2008-10-09 | バイオ−ラッド ラボラトリーズ インコーポレーティッド | Diverse chemical libraries bound to small particles with paramagnetic properties |
US20090247421A1 (en) * | 2005-03-23 | 2009-10-01 | Egisto Boschetti | Diverse chemical libraries bound to small particles with paramagnetic properties |
AU2006232370B2 (en) * | 2005-04-01 | 2011-10-06 | Banyan Biomarkers | Biomakers of liver injury |
US8048638B2 (en) * | 2005-04-01 | 2011-11-01 | University Of Florida Research Foundation, Inc. | Biomarkers of liver injury |
US7972867B2 (en) * | 2005-04-06 | 2011-07-05 | Quest Diagnostics Investments Incorporated | Methods for detecting vitamin D metabolites by mass spectrometry |
US7745226B2 (en) * | 2005-04-06 | 2010-06-29 | Quest Diagnostics Investments Incorporated | Methods for detecting vitamin D metabolites |
BRPI0609302A2 (en) | 2005-04-15 | 2011-10-11 | Becton Dickinson Co | methods for predicting the development of sepsis and for diagnosing sepsis in an individual to be tested, microarray, kit for predicting the development of sepsis in an individual to be tested, computer program product, computer, computer system for determining if an individual is likely to develop sepsis, digital signal embedded in a carrier wave, and, graphical user interface to determine if an individual is likely to develop sepsis |
US7622273B2 (en) * | 2005-05-11 | 2009-11-24 | Gibbs Bernard F | Method for chemical and enzymatic treatment of posttranslationally modified proteins bound to a protein chip |
US20080312514A1 (en) * | 2005-05-12 | 2008-12-18 | Mansfield Brian C | Serum Patterns Predictive of Breast Cancer |
US20070003954A1 (en) * | 2005-05-12 | 2007-01-04 | The Board Of Regents Of The University Of Texas System | Protein and antibody profiling using small molecule microarrays |
WO2006125094A2 (en) * | 2005-05-18 | 2006-11-23 | Board Of Regents, The University Of Texas System | Combinatorial selection of phosphorothioate aptamers for rnases |
US20060261267A1 (en) * | 2005-05-20 | 2006-11-23 | Agency For Science, Technology And Research | Composite MALDI matrix material and methods of using it and kits thereof in MALDI |
US7435951B2 (en) * | 2005-06-08 | 2008-10-14 | Agilent Technologies, Inc. | Ion source sample plate illumination system |
EP1896493A1 (en) | 2005-06-17 | 2008-03-12 | North Carolina A & T State University | A device including a proteinaceous factor, a recombinant proteinaceous factor, and a nucleotide sequence encoding the proteinaceous factor |
WO2007002527A2 (en) | 2005-06-24 | 2007-01-04 | Ciphergen Biosystems, Inc. | BIOMARKERS FOR OVARIAN CANCER: β-2 MICROGLOBULIN |
ITTO20050569A1 (en) * | 2005-08-09 | 2007-02-10 | St Microelectronics Srl | DEVICE AND METHOD OF DETERMINING THE CONTACT POSITION AND CONTACT SENSITIVE ELECTRONIC DEVICE |
US7495231B2 (en) * | 2005-09-08 | 2009-02-24 | Agilent Technologies, Inc. | MALDI sample plate imaging workstation |
DE102005044307B4 (en) * | 2005-09-16 | 2008-04-17 | Bruker Daltonik Gmbh | Ionization of desorbed molecules |
US20070202515A1 (en) * | 2005-10-12 | 2007-08-30 | Pathologica, Llc. | Promac signature application |
EP1952147A2 (en) | 2005-11-16 | 2008-08-06 | Novartis AG | Biomarkers for anti-nogo-a antibody treatment in spinal cord injury |
US7889347B2 (en) * | 2005-11-21 | 2011-02-15 | Plexera Llc | Surface plasmon resonance spectrometer with an actuator driven angle scanning mechanism |
US20070127164A1 (en) * | 2005-11-21 | 2007-06-07 | Physical Logic Ag | Nanoscale Sensor |
US7463358B2 (en) * | 2005-12-06 | 2008-12-09 | Lumera Corporation | Highly stable surface plasmon resonance plates, microarrays, and methods |
WO2007070809A2 (en) * | 2005-12-12 | 2007-06-21 | Mcgill University | Biomarkers for babesia |
WO2007076439A2 (en) | 2005-12-22 | 2007-07-05 | Abbott Laboratories | Methods and marker combinations for screening for predisposition to lung cancer |
US9347945B2 (en) | 2005-12-22 | 2016-05-24 | Abbott Molecular Inc. | Methods and marker combinations for screening for predisposition to lung cancer |
AU2007209980A1 (en) * | 2006-01-27 | 2007-08-09 | Eastern Virginia Medical School | Proteomic fingerprinting of human IVF-derived embryos: identification of biomarkers of developmental potential |
CA2642833A1 (en) | 2006-02-17 | 2007-08-30 | Children's Medical Center Corporation | Free ngal as a biomarker for cancer |
EP1994314A4 (en) * | 2006-03-06 | 2011-10-26 | Acs Ind Inc | Sliding sealing connector |
WO2007120999A2 (en) * | 2006-03-06 | 2007-10-25 | Bio-Rad Laboratories, Inc. | Chelating monomers and polymers |
WO2007106466A2 (en) | 2006-03-11 | 2007-09-20 | The Board Of Trustees Of The Leland Stanford Junior University | Beta-2 microglobulin as a biomarker for peripheral artery disease |
EP2010895A2 (en) * | 2006-03-29 | 2009-01-07 | Cangen Biotechnologies, Inc. | Apparatus and method for predicting disease |
US20070231915A1 (en) * | 2006-03-29 | 2007-10-04 | Cangen Biotechnologies, Inc. | Apparatus and method for filtration to enhance the detection of peaks |
US20070231917A1 (en) * | 2006-03-29 | 2007-10-04 | Cangen Biotechnologies, Inc. | Apparatus and method for filtration to enhance the detection of peaks |
US20070238193A1 (en) * | 2006-03-29 | 2007-10-11 | Cangen Biotechnologies, Inc. | Apparatus and method for filtration to enhance the detection of peaks |
KR20090027608A (en) * | 2006-03-29 | 2009-03-17 | 칸젠 바이오테크날러지즈, 인코포레이티드 | Methods of predicting response to a treatment for a disease |
US20070231916A1 (en) * | 2006-03-29 | 2007-10-04 | Cangen Biotechnologies, Inc. | Apparatus and method for filtration to enhance the detection of peaks |
US8518926B2 (en) * | 2006-04-10 | 2013-08-27 | Knopp Neurosciences, Inc. | Compositions and methods of using (R)-pramipexole |
WO2007123908A2 (en) | 2006-04-18 | 2007-11-01 | Advanced Liquid Logic, Inc. | Droplet-based multiwell operations |
WO2007133714A2 (en) * | 2006-05-12 | 2007-11-22 | Stratos Biosystems, Llc | Analyte focusing biochips for affinity mass spectrometry |
CA2652251A1 (en) | 2006-05-16 | 2007-11-29 | Knopp Neurosciences, Inc. | Compositions of r(+) and s(-) pramipexole and methods for using the same |
US7935921B2 (en) * | 2006-05-26 | 2011-05-03 | Laboratory Corporation Of America Holdings | Methods and systems for the quantitative analysis of biomarkers |
US20080193772A1 (en) * | 2006-07-07 | 2008-08-14 | Bio-Rad Laboratories, Inc | Mass spectrometry probes having hydrophobic coatiings |
US7972794B2 (en) * | 2006-07-18 | 2011-07-05 | Quest Diagnostics Investments Incorporated | Oxidized apoA-I determination by mass spectrometry |
ES2446266T3 (en) | 2006-07-21 | 2014-03-06 | Amgen Inc. | Method of detection and / or measurement of hepcidin in a sample |
AT504100B9 (en) * | 2006-08-25 | 2009-12-15 | Leopold Franzens Uni Innsbruck | MATRIX-FREE MALDI MASS SPECTROMETRY |
ES2655564T3 (en) | 2006-09-07 | 2018-02-20 | Otago Innovation Limited | Biomarker for the early detection of acute heart disorders |
US8017015B2 (en) | 2006-10-20 | 2011-09-13 | Quest Diagnostics Investments Incorporated | Monolithic column chromatography |
US20080128608A1 (en) * | 2006-11-06 | 2008-06-05 | The Scripps Research Institute | Nanostructure-initiator mass spectrometry |
WO2008062372A2 (en) * | 2006-11-23 | 2008-05-29 | Philips Intellectual Property & Standards Gmbh | Device for separation and maldi analysis of an analyte in a sample |
US8524695B2 (en) * | 2006-12-14 | 2013-09-03 | Knopp Neurosciences, Inc. | Modified release formulations of (6R)-4,5,6,7-tetrahydro-N6-propyl-2,6-benzothiazole-diamine and methods of using the same |
JP2010514804A (en) * | 2006-12-29 | 2010-05-06 | ザ・ソーク・インスティチュート・フォー・バイオロジカル・スタディーズ | Ways to increase athletic performance |
JP4984900B2 (en) * | 2007-01-12 | 2012-07-25 | 株式会社島津製作所 | Mass spectrometry using polymer-coated microparticles |
WO2008100941A2 (en) * | 2007-02-12 | 2008-08-21 | Correlogic Systems Inc. | A method for calibrating an analytical instrument |
CA2680556A1 (en) | 2007-03-12 | 2008-09-18 | Miraculins Inc. | Biomarkers of prostate cancer and uses thereof |
US8519148B2 (en) | 2007-03-14 | 2013-08-27 | Knopp Neurosciences, Inc. | Synthesis of chirally purified substituted benzothiazole diamines |
EP2210099A4 (en) | 2007-03-27 | 2011-03-16 | Vermillion Inc | Biomarkers for ovarian cancer |
US8399486B2 (en) * | 2007-04-09 | 2013-03-19 | Purdue Pharma L.P. | Benzenesulfonyl compounds and the use thereof |
EP2162552A4 (en) | 2007-05-11 | 2010-06-30 | Univ Johns Hopkins | Biomarkers for melanoma |
US9091695B2 (en) * | 2007-06-01 | 2015-07-28 | Laboratory Corporation Of America Holdings | Methods and systems for quantification of peptides and other analytes |
US20100184110A1 (en) * | 2007-06-06 | 2010-07-22 | Siemens Healthcare Diagnostics Inc. | Predictive diagnostics for kidney disease |
US8017403B2 (en) * | 2007-06-14 | 2011-09-13 | Quest Diagnostics Investments Incorporated | Mass spectrometry method for measuring vitamin B6 in body fluid |
EP2174957B1 (en) | 2007-06-15 | 2016-03-16 | Xiamen University | Monoclonal antibodies binding to avian influenza virus subtype h5 haemagglutinin and uses thereof |
EP3666284A1 (en) | 2007-06-22 | 2020-06-17 | Children's Medical Center, Corp. | Methods and uses thereof of a fragment of saposin a |
EP2637020A3 (en) | 2007-06-29 | 2014-01-08 | Correlogic Systems Inc. | Predictive markers for ovarian cancer |
US11311917B2 (en) | 2007-08-09 | 2022-04-26 | Bruker Nano, Inc. | Apparatus and method for contamination identification |
US20090060786A1 (en) * | 2007-08-29 | 2009-03-05 | Gibum Kim | Microfluidic apparatus for wide area microarrays |
WO2009039122A2 (en) | 2007-09-17 | 2009-03-26 | Sequenom, Inc. | Integrated robotic sample transfer device |
WO2009058331A2 (en) | 2007-10-29 | 2009-05-07 | Vermilllion, Inc. | Biomarkers for the detection of early stage ovarian cancer |
WO2009061313A1 (en) * | 2007-11-06 | 2009-05-14 | The Scripps Research Institute | Nanostructure-initiator mass spectrometry |
US20090134325A1 (en) | 2007-11-27 | 2009-05-28 | Goldman Mildred M | Methods for detecting estradiol by mass spectrometry |
US7972868B2 (en) * | 2007-11-28 | 2011-07-05 | Quest Diagnostics Investments Incorporated | Methods for detecting dihydroxyvitamin D metabolites by mass spectrometry |
EP3536336A1 (en) | 2007-11-30 | 2019-09-11 | Siemens Healthcare Diagnostics Inc. | Adiponectin receptor fragments and methods of use |
US8030084B2 (en) * | 2007-12-06 | 2011-10-04 | Quest Diagnostics Investments Incorporated | Thyroglobulin quantitation by mass spectrometry |
US8916385B2 (en) | 2007-12-13 | 2014-12-23 | Quest Diagnostics Investments, Inc. | Methods for detecting estrone by mass spectrometry |
US8004669B1 (en) | 2007-12-18 | 2011-08-23 | Plexera Llc | SPR apparatus with a high performance fluid delivery system |
TW200933195A (en) * | 2008-01-28 | 2009-08-01 | Ind Tech Res Inst | Autostereoscopic display |
CA2715914C (en) | 2008-03-12 | 2019-01-22 | Otago Innovation Limited | Insulin signal peptide fragment biomarkers |
AU2009224114B2 (en) | 2008-03-12 | 2013-02-21 | Otago Innovation Limited | Biomarkers |
EP2260305A1 (en) * | 2008-03-27 | 2010-12-15 | INSERM (Institut National de la Santé et de la Recherche Medicale) | Methods and kits for determining the occurrence of a liver disease in a subject |
US8669113B2 (en) | 2008-04-03 | 2014-03-11 | Becton, Dickinson And Company | Advanced detection of sepsis |
JP5258360B2 (en) * | 2008-04-14 | 2013-08-07 | 富士フイルム株式会社 | Immunochromatography measurement method and immunochromatography measurement kit |
US7776522B2 (en) | 2008-04-24 | 2010-08-17 | Becton, Dickinson And Company | Methods for diagnosing oncogenic human papillomavirus (HPV) |
US8673644B2 (en) | 2008-05-13 | 2014-03-18 | Battelle Memorial Institute | Serum markers for type II diabetes mellitus |
WO2009149124A1 (en) * | 2008-06-02 | 2009-12-10 | Bio-Rad Laboratories, Inc. | Mass spectrometric detection of material transferred to a surface |
WO2010123720A1 (en) | 2009-04-23 | 2010-10-28 | Siemens Healthcare Diagnostics Inc. | Monomeric and dimeric forms of adiponectin receptor fragments and methods of use |
US7834313B2 (en) | 2008-08-08 | 2010-11-16 | Quest Diagnostics Investments Incorporated | Mass spectrometry assay for plasma-renin |
US8106351B2 (en) * | 2008-08-08 | 2012-01-31 | Quest Diagnostics Investments Incorporated | Mass spectrometry assay for plasma-renin |
KR20110071064A (en) | 2008-08-19 | 2011-06-28 | 크놉 뉴로사이언시스 인코포레이티드 | Compositions and methods of using (r)-pramipexole |
US7893399B2 (en) * | 2008-09-09 | 2011-02-22 | Quest Diagnostics Investments Incorporated | Methods for detecting dehydroepiandrosterone by mass spectrometry |
US7952067B2 (en) * | 2008-10-06 | 2011-05-31 | Quest Diagnostics Investments Incorporated | Methods for detecting vitamin C by mass spectrometry |
US7804063B2 (en) | 2008-10-06 | 2010-09-28 | Quest Diagnostics Investments Incorporated | Methods for detecting dihydrotestosterone by mass spectrometry |
WO2010054379A2 (en) | 2008-11-10 | 2010-05-14 | The United States Of America, As Represensted By The Secretary, Department Of Health And Human Services | Gene signature for predicting prognosis of patients with solid tumors |
US7952068B2 (en) * | 2008-12-16 | 2011-05-31 | Quest Diagnostics Investments Incorporated | Methods for detecting catecholamines by mass spectrometry |
US8039794B2 (en) | 2008-12-16 | 2011-10-18 | Quest Diagnostics Investments Incorporated | Mass spectrometry assay for thiopurine-S-methyl transferase activity and products generated thereby |
US8399829B2 (en) | 2008-12-18 | 2013-03-19 | Quest Diagnostics Investments Incorporated | Vitamin B2 detection by mass spectrometry |
WO2010075175A1 (en) | 2008-12-23 | 2010-07-01 | Quest Diagnostics Investments Incorporated | Mass spectrometry assay for estrogenic compounds |
EP2384437B1 (en) | 2008-12-24 | 2018-12-12 | Quest Diagnostics Investments Incorporated | Mass spectrometry assay for pregnenolone and 17-hydroxypregnenolone |
CA3013992A1 (en) | 2008-12-30 | 2010-07-08 | Children's Medical Center Corporation | Method of predicting acute appendicitis |
WO2010079253A2 (en) | 2009-01-09 | 2010-07-15 | Proyecto De Biomedicina Cima, S.L. | Bio-markers for diagnosing fibrosis |
WO2010087985A2 (en) | 2009-01-28 | 2010-08-05 | Yale University | Novel markers for detection of complications resulting from in utero encounters |
WO2010093872A2 (en) | 2009-02-13 | 2010-08-19 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Molecular-based method of cancer diagnosis and prognosis |
CN102449481B (en) * | 2009-05-29 | 2016-05-25 | 德克萨斯大学系统董事会 | For separating of with the class peptide part of processing autoimmune T cell |
AU2010256880B2 (en) * | 2009-06-02 | 2015-01-22 | Opko Health, Inc. | Identification of small molecules recognized by antibodies in subjects with neurodegenerative diseases |
JP4993632B2 (en) * | 2009-06-16 | 2012-08-08 | 朝日インテック株式会社 | Medical guidewire |
EP2459742B1 (en) | 2009-07-29 | 2016-04-06 | Pharnext | New diagnostic tools for alzheimer disease |
WO2011047257A1 (en) * | 2009-10-16 | 2011-04-21 | The Board Of Regents Of The University Of Texas System | Compositions and methods for producing cyclic peptoid libraries |
US20110111512A1 (en) * | 2009-11-05 | 2011-05-12 | Cory Bystrom | Quantitation of insulin-like growth factor-i and insulin-like growth factor-ii with high-resolution mass spectrometry |
US8304248B2 (en) * | 2009-11-16 | 2012-11-06 | Torres Anthony R | Protein separation via ion-exchange chromatography and associated methods, systems, and devices |
US7977117B2 (en) * | 2009-12-03 | 2011-07-12 | Quest Diagnostics Investments Incorprated | Vitamin D metabolite determination utilizing mass spectrometry following derivatization |
US8034627B2 (en) | 2009-12-03 | 2011-10-11 | Quest Diagnostics Investments Incorporated | Methods for detecting dihydroxyvitamin D metabolites by mass spectrometry |
JP5739903B2 (en) | 2009-12-11 | 2015-06-24 | クエスト ダイアグノスティックス インヴェストメンツ インコーポレイテッド | Mass spectrometry of steroidal compounds in complex samples |
US20110240840A1 (en) | 2009-12-11 | 2011-10-06 | Quest Diagnostics Investments Incorporated | Mass spectrometric determination of cookson-derivatized, non-metabolized vitamin d |
CA2822026C (en) | 2009-12-17 | 2018-06-12 | Children's Medical Center Corporation | Saposin-a derived peptides and uses thereof |
WO2011084751A1 (en) * | 2009-12-21 | 2011-07-14 | Quest Diagnostics Investments Incorporated | Glucagon detection and quantitation by mass spectrometry |
EP2531224B1 (en) | 2010-01-26 | 2019-06-05 | Bioregency, Inc. | Compositions and methods relating to argininosuccinate synthetase |
WO2011149943A1 (en) | 2010-05-24 | 2011-12-01 | Ventana Midical Systems, Inc. | Method for differentiation of non-small cellung carcinoma |
WO2011156505A1 (en) | 2010-06-09 | 2011-12-15 | Quest Diagnostics Investments Incorporated | Mass spectrometric determination of derivatized methylmalonic acid |
EP3246335A3 (en) | 2010-07-19 | 2017-12-27 | Otago Innovation Limited | Signal biomarkers |
US20140031250A1 (en) | 2010-10-07 | 2014-01-30 | David Tsai Ting | Biomarkers of Cancer |
JP6071886B2 (en) | 2010-10-14 | 2017-02-01 | ザ・ジョンズ・ホプキンス・ユニバーシティ | Brain injury biomarkers |
WO2012087438A1 (en) | 2010-11-08 | 2012-06-28 | Georgetown University | Methods for simultaneous quantification of thyroid hormones and metabolites thereof by mass spectrometry |
CN103392219B (en) | 2010-12-28 | 2017-02-08 | 探索诊断投资公司 | Quantitation of insulin by mass spectrometry |
US9177766B2 (en) | 2010-12-30 | 2015-11-03 | Quest Diagnostics Investments Incorporated | Mass spectrometric quantitation assay for metabolites of leflunomide |
EP2707389B1 (en) | 2011-05-12 | 2019-10-30 | The Johns Hopkins University | Assay reagents for a neurogranin diagnostic kit |
US8728824B2 (en) | 2011-06-22 | 2014-05-20 | Quest Diagnostics Investments Inc. | Mass spectrometric determination of fatty acids |
JP2014527036A (en) | 2011-06-27 | 2014-10-09 | ザ ジャクソン ラボラトリー | Methods and compositions for the treatment of cancer and autoimmune diseases |
WO2013055911A1 (en) | 2011-10-14 | 2013-04-18 | Dana-Farber Cancer Institute, Inc. | Znf365/zfp365 biomarker predictive of anti-cancer response |
JP6285865B2 (en) | 2011-11-14 | 2018-02-28 | アルファシグマ ソシエタ ペル アチオニ | Assays and methods for selecting treatment regimens for subjects with depression |
WO2013078222A1 (en) | 2011-11-23 | 2013-05-30 | Quest Diagnostics Investments Incorporated | Kisspeptin-54 detection by tandem mass spectrometry |
US8669519B2 (en) | 2011-12-05 | 2014-03-11 | Quest Diagnostics Investments, Inc. | Methods for detecting reverse triiodothyronine by mass spectrometry |
US9512096B2 (en) | 2011-12-22 | 2016-12-06 | Knopp Biosciences, LLP | Synthesis of amine substituted 4,5,6,7-tetrahydrobenzothiazole compounds |
AU2012358269B2 (en) | 2011-12-22 | 2017-11-02 | Children's Medical Center Corporation | Saposin-A derived peptides and uses thereof |
US8779355B2 (en) | 2011-12-28 | 2014-07-15 | Quest Diagnostics Investments, Inc. | Methods for detecting lacosamide by mass spectrometry |
DK2800578T3 (en) | 2012-01-05 | 2019-03-25 | Boston Medical Ct Corp | SLIT-ROBO SIGNAL FOR DIAGNOSIS AND TREATMENT OF Kidney Diseases |
WO2013106886A1 (en) | 2012-01-20 | 2013-07-25 | Adelaide Research & Innovation Pty Ltd | Biomarkers for gastric cancer and uses thereof |
EP2807271B1 (en) | 2012-01-24 | 2018-08-22 | CD Diagnostics, Inc. | System for detecting infection in synovial fluid |
WO2013131068A1 (en) | 2012-03-02 | 2013-09-06 | Berg Pharma, Llc | Methods and kits for detection of coenzyme q10 |
DK2828282T3 (en) | 2012-03-20 | 2018-03-05 | Otago Innovation Ltd | Biomarkers |
WO2013192616A1 (en) | 2012-06-22 | 2013-12-27 | Htg Molecular Diagnostics, Inc. | Molecular malignancy in melanocytic lesions |
EP2680005A1 (en) | 2012-06-28 | 2014-01-01 | Rheinische Friedrich-Wilhelms-Universität Bonn | Lipid analysis |
EP2890982B1 (en) | 2012-08-28 | 2020-12-16 | Puget Sound Blood Center | Biochemical markers of red blood cell storage and toxicity |
JP5902357B2 (en) | 2012-09-20 | 2016-04-13 | クエスト ダイアグノスティックス インヴェストメンツ インコーポレイテッド | Thyroglobulin quantification by mass spectrometry |
AU2013202668B2 (en) | 2012-12-24 | 2014-12-18 | Adelaide Research & Innovation Pty Ltd | Inhibition of cancer growth and metastasis |
CN114324893A (en) | 2012-12-26 | 2022-04-12 | 奎斯特诊断投资公司 | C-peptide detection by mass spectrometry |
US9662313B2 (en) | 2013-02-28 | 2017-05-30 | Knopp Biosciences Llc | Compositions and methods for treating amyotrophic lateral sclerosis in responders |
EP4286853A3 (en) | 2013-05-10 | 2024-03-06 | Johns Hopkins University | Compositions for ovarian cancer assessment having improved specificity |
AU2014268417A1 (en) | 2013-05-23 | 2015-11-26 | Iphenotype Llc | Methods and systems for assisting persons, product providers and/or service providers |
RS61539B1 (en) | 2013-07-12 | 2021-04-29 | Knopp Biosciences Llc | Treating elevated levels of eosinophils and/or basophils |
US9468630B2 (en) | 2013-07-12 | 2016-10-18 | Knopp Biosciences Llc | Compositions and methods for treating conditions related to increased eosinophils |
EP3022322A4 (en) | 2013-07-17 | 2017-05-17 | The Johns Hopkins University | A multi-protein biomarker assay for brain injury detection and outcome |
WO2015020523A1 (en) | 2013-08-07 | 2015-02-12 | Stichting Vu-Vumc | Biomarkers for early diagnosis of alzheimer's disease |
CA2921381A1 (en) | 2013-08-13 | 2015-02-19 | Knopp Biosciences Llc | Compositions and methods for treating chronic urticaria |
WO2015023786A1 (en) | 2013-08-13 | 2015-02-19 | Knopp Biosciences Llc | Compositions and methods for treating plasma cell disorders and b-cell prolymphocytic disorders |
WO2015030585A2 (en) | 2013-08-27 | 2015-03-05 | Academisch Ziekenhuis Leiden H.O.D.N. Lumc | Methods for detecting post-translationally modified lysines in a polypeptide |
CN103822964B (en) * | 2013-10-21 | 2016-02-24 | 南昌大学 | Chloromycetin in neutral desorb-electron spray extraction MALDI-MS direct-detection honey |
WO2015073709A2 (en) | 2013-11-14 | 2015-05-21 | The United States Of America, As Represented By The Secretary, Department Of Health & Human Services | Detection of atherosclerotic cardiovascular disease risk and heart failure risk |
HUE051159T2 (en) | 2013-12-20 | 2021-03-01 | Univ Lausanne | Diagnostic, prognostic and therapeutic uses of long noncoding rnas for heart disease and regenerative medicine |
US10398772B2 (en) | 2014-01-08 | 2019-09-03 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Ras pathways as markers of protection against HIV and methods to improve vaccine efficacy |
WO2015152724A2 (en) | 2014-04-02 | 2015-10-08 | Stichting Vu-Vumc | Biomarkers for the detection of frontotemporal dementia |
US11624093B2 (en) | 2014-04-24 | 2023-04-11 | Dana-Farber Cancer Institute, Inc. | Tumor suppressor and oncogene biomarkers predictive of anti-immune checkpoint inhibitor response |
BR112016026459B1 (en) | 2014-05-12 | 2022-09-27 | Quest Diagnostics Investments Incorporated | METHODS TO DETERMINE THE QUANTITY OF NORENDOXIFEN AND TO DETERMINE THE QUANTITY OF TAMOXIFEN AND TAMOXIFEN METABOLITES IN A HUMAN SAMPLE BY MASS SPECTROMETRY |
CA2988172C (en) * | 2014-06-13 | 2018-10-02 | Jp Scientific Limited | A probe for extraction of molecules of interest from a sample |
EP3161159B1 (en) | 2014-06-25 | 2020-08-05 | The General Hospital Corporation | Targeting human satellite ii (hsatii) |
US10222386B2 (en) | 2014-09-19 | 2019-03-05 | The Johns Hopkins University | Biomarkers of congnitive dysfunction |
CA2972500C (en) * | 2014-12-31 | 2023-09-12 | Fluidigm Canada Inc. | Structured biological samples for analysis by mass cytometry |
US20180003721A1 (en) | 2015-01-15 | 2018-01-04 | Joslin Diabetes Center | Metabolite Biomarkers Predictive Of Renal Disease In Diabetic Patients |
JP6813503B2 (en) | 2015-02-10 | 2021-01-13 | ベー.エル.アー.ハー.エム.エス ゲゼルシャフト ミット ベシュレンクテル ハフツング | Free histone protein as a biomarker |
EP3259594A4 (en) | 2015-02-20 | 2018-12-26 | The Johns Hopkins University | Biomarkers of myocardial injury |
US10324082B2 (en) | 2015-03-03 | 2019-06-18 | Quest Diagnostics Investments Llc | Methods for quantitation of insulin levels by mass spectrometry |
WO2016183585A1 (en) | 2015-05-14 | 2016-11-17 | Joslin Diabetes Center, Inc. | Retinol-binding protein 3 (rbp3) as a protective factor in non-diabetic retinal degeneration |
EP3331572A4 (en) | 2015-08-04 | 2019-05-01 | CD Diagnostics, Inc. | Methods for detecting adverse local tissue reaction (altr) necrosis |
US11360098B2 (en) | 2015-09-28 | 2022-06-14 | Quest Diagnostics Investments Llc | Amyloid beta detection by mass spectrometry |
WO2017099829A1 (en) | 2015-12-11 | 2017-06-15 | The General Hospital Corporation | Compositions and methods for treating drug-tolerant glioblastoma |
US11408900B2 (en) | 2016-01-15 | 2022-08-09 | Massachusetts Eye And Ear Infirmary | Secreted P-glycoprotein is a non-invasive biomarker of chronic rhinosinusitis |
WO2017125406A1 (en) | 2016-01-19 | 2017-07-27 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods of predicting left ventricular remodeling in subjects suffering from hypertension |
US11306362B2 (en) | 2016-02-08 | 2022-04-19 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Gene signature predictive of hepatocellular carcinoma response to transcatheter arterial chemoembolization (TACE) |
US20200200735A9 (en) | 2016-02-22 | 2020-06-25 | Ursure, Inc. | System and method for detecting therapeutic agents to monitor adherence to a treatment regimen |
EP3423186A4 (en) | 2016-03-02 | 2019-10-23 | JP Scientific Limited | Solid phase microextraction coating |
CA3019256A1 (en) | 2016-05-10 | 2017-11-16 | Jp Scientific Limited | System and method for desorbing and detecting an analyte sorbed on a solid phase microextraction device |
KR101747038B1 (en) | 2016-06-27 | 2017-06-15 | 이현영 | Nanopolymer Having Heteromorphic Polymer Structure, Preparation Method Thereof, Nucleic Acid Reaction Composition Containing Thereof, and Method of Detecting or Quantifying Nucleic Acid Using Nucleic Acid Reaction Composition Containing Thereof |
WO2018089764A1 (en) | 2016-11-11 | 2018-05-17 | Ascendant Dx, Llc | Compositions and methods for diagnosing and differentiating systemic juvenile idiopathic arthritis and kawasaki disease |
CA3058642A1 (en) | 2017-03-31 | 2018-10-04 | Quest Diagnostics Investments Llc | Methods for quantitation of insulin and c-peptide |
DE102017206155A1 (en) | 2017-04-11 | 2018-10-11 | Robert Bosch Gmbh | Desorption of nucleic acids |
CN111148998B (en) | 2017-07-31 | 2023-11-21 | 奎斯特诊断投资有限公司 | Apolipoprotein E isoform detection by mass spectrometry |
US11860141B2 (en) | 2017-08-14 | 2024-01-02 | Quest Diagnostics Investments Llc | Detection and quantitation of guanidinoacetate, creatine, and creatinine by mass spectrometry |
EP4339298A3 (en) | 2017-09-25 | 2024-04-17 | Fred Hutchinson Cancer Center | High efficiency targeted in situ genome-wide profiling |
CA3090652A1 (en) | 2018-02-06 | 2019-08-15 | The General Hospital Corporation | Repeat rna as biomarkers of tumor immune response |
GB201802123D0 (en) | 2018-02-09 | 2018-03-28 | Metabolomic Diagnostics Ltd | A method of processomg a biological sample |
JP6916446B2 (en) * | 2018-09-13 | 2021-08-11 | 日本電信電話株式会社 | Base station management method, base station management device and program |
EP3850370A1 (en) | 2018-09-14 | 2021-07-21 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Use of amniotic fluid peptides for predicting postnatal renal function in congenital anomalies of the kidney and the urinary tract |
WO2020104458A1 (en) | 2018-11-20 | 2020-05-28 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods and kits for detecting liver dysfunction in a subject |
EP3677693A1 (en) | 2019-01-03 | 2020-07-08 | Ecole Polytechnique Federale De Lausanne (EPFL) EPFL-TTO | Transpochimeric gene trancripts (tcgts) as cancer biomarkers |
CN114585915B (en) | 2019-10-10 | 2024-02-23 | 瑞泽恩制药公司 | Liquid chromatography-mass spectrometry (LC-MS) method for analyzing ampholyte batch changes |
EP4097256A1 (en) | 2020-01-31 | 2022-12-07 | Regeneron Pharmaceuticals, Inc. | Use of liquid chromatography and mass spectrometry to characterize oligonucleotides |
US20230324412A1 (en) | 2020-04-09 | 2023-10-12 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods and compositions to determine the quality of red blood cell units |
MX2022013173A (en) | 2020-04-24 | 2022-11-30 | Hoffmann La Roche | Enzyme and pathway modulation with sulfhydryl compounds and their derivatives. |
US20230187018A1 (en) * | 2020-05-20 | 2023-06-15 | Purdue Research Foundation | Integrated synthesis and analysis systems and methods of use thereof |
WO2022086852A2 (en) | 2020-10-19 | 2022-04-28 | Dana-Farber Cancer Institute, Inc. | Germline biomarkers of clinical response and benefit to immune checkpoint inhibitor therapy |
US20220133735A1 (en) | 2020-11-02 | 2022-05-05 | Trethera Corporation | Crystalline forms of a deoxycytidine kinase inhibitor and uses thereof |
CN112540118B (en) * | 2020-12-03 | 2022-03-11 | 福州大学 | Method for rapidly detecting metal ions based on mercaptobenzoic acid-assisted laser desorption ionization mass spectrum |
WO2022196275A1 (en) | 2021-03-17 | 2022-09-22 | 日本水産株式会社 | Purification method and purified product |
EP4347889A1 (en) | 2021-05-28 | 2024-04-10 | Centre Hospitalier Universitaire Vaudois (CHUV) | Novel incrna controlling cardiac fibrosis |
WO2023122723A1 (en) | 2021-12-23 | 2023-06-29 | The Broad Institute, Inc. | Panels and methods for diagnosing and treating lung cancer |
WO2024074685A1 (en) | 2022-10-07 | 2024-04-11 | Institut National de la Santé et de la Recherche Médicale | Use of albumin isoforms profiles for the characterization of the etiology and severity of liver injuries |
Family Cites Families (50)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4022876A (en) * | 1973-06-21 | 1977-05-10 | Stanford Research Institute | Mass spectrometric immunoassay |
US3896661A (en) * | 1974-01-09 | 1975-07-29 | Stanford Research Inst | Method of coupling thin layer chromatograph with mass spectrometer |
DE2540505A1 (en) * | 1975-09-11 | 1977-03-24 | Leybold Heraeus Gmbh & Co Kg | FLIGHT TIME MASS SPECTROMETERS FOR IONS WITH DIFFERENT ENERGIES |
JPS604742Y2 (en) * | 1978-04-08 | 1985-02-12 | 固 青木 | nozzle device |
US4296332A (en) * | 1979-12-28 | 1981-10-20 | Sperry Corporation | Sprocket hole sensing detector for moving translucent paper sheets |
DE3125335A1 (en) | 1981-06-27 | 1983-01-13 | Alfred Prof. Dr. 4400 Münster Benninghoven | METHOD FOR ANALYZING GASES AND LIQUIDS |
US4454233A (en) * | 1981-10-21 | 1984-06-12 | Wang Associates | Method of tagged immunoassay |
DE3201264A1 (en) * | 1982-01-16 | 1983-07-28 | Leybold-Heraeus GmbH, 5000 Köln | LASER MICRO PROBE |
DE3221681A1 (en) * | 1982-06-08 | 1983-12-08 | Bayer Ag, 5090 Leverkusen | Mass spectrometer with an external sample holder |
DE3321681A1 (en) | 1983-06-15 | 1984-12-20 | Fogra Deutsche Forschungsgesellschaft für Druck- und Reproduktionstechnik e.V., 8000 München | Process for the removal of volatile substances from layers |
US4665192A (en) * | 1984-03-19 | 1987-05-12 | The Rockefeller University | 2-(2-furoyl)-4(5)-2(furanyl)-1H-imidazole |
DE3417638A1 (en) * | 1984-05-10 | 1985-11-14 | Schering AG, 1000 Berlin und 4709 Bergkamen | METHOD FOR DETERMINING LOW AMOUNT OF SUBSTANCES OF MEDICINAL PRODUCTS, BODY'S OWN OR OTHER CHEMICAL SUBSTANCES IN BIOLOGICAL MATERIAL |
US4902627A (en) * | 1985-02-05 | 1990-02-20 | The United States Of America As Represented By The Secretary Of The Navy | Method for detecting amine-containing drugs in body fluids by sims |
US6060237A (en) | 1985-02-26 | 2000-05-09 | Biostar, Inc. | Devices and methods for optical detection of nucleic acid hybridization |
DE3517667A1 (en) * | 1985-05-15 | 1986-11-20 | Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V., 3400 Göttingen | LASER MASS SPECTROMETER |
FR2586657B1 (en) * | 1985-09-04 | 1991-03-22 | Lapouyade Sa | DEVICE FOR GRIPPING SUPPORTS OR LOAD CONTAINERS |
US4694167A (en) * | 1985-11-27 | 1987-09-15 | Atom Sciences, Inc. | Double pulsed time-of-flight mass spectrometer |
US4705616A (en) * | 1986-09-15 | 1987-11-10 | Sepragen Corporation | Electrophoresis-mass spectrometry probe |
JPS63124543A (en) * | 1986-11-14 | 1988-05-28 | Hitachi Electronics Eng Co Ltd | Plate chucking mechanism |
US4988879A (en) * | 1987-02-24 | 1991-01-29 | The Board Of Trustees Of The Leland Stanford Junior College | Apparatus and method for laser desorption of molecules for quantitation |
JPH01197211A (en) * | 1988-01-30 | 1989-08-08 | Canon Inc | Device for driving pallet |
DE3809504C1 (en) * | 1988-03-22 | 1989-09-21 | Bruker - Franzen Analytik Gmbh, 2800 Bremen, De | |
US5003059A (en) * | 1988-06-20 | 1991-03-26 | Genomyx, Inc. | Determining DNA sequences by mass spectrometry |
JPH0249209U (en) * | 1988-09-29 | 1990-04-05 | ||
US5078135A (en) * | 1989-05-31 | 1992-01-07 | Board Of Regents, The University Of Texas System | Apparatus for in vivo analysis of biological compounds in blood or tissue by microdialysis and mass spectrometry |
GB2235529B (en) * | 1989-08-23 | 1993-07-28 | Finnigan Mat Ltd | Method of preparing samples for laser spectrometry analysis |
GB2236185B (en) * | 1989-08-22 | 1994-03-23 | Finnigan Mat Gmbh | Process,specimen and device for making an analyte available for an investigation |
GB2236186B (en) * | 1989-08-22 | 1994-01-05 | Finnigan Mat Gmbh | Process and device for laser desorption of analyte molecular ions, especially of biomolecules |
GB2235528B (en) * | 1989-08-23 | 1993-07-28 | Finnigan Mat Ltd | Method of preparing samples for laser spectrometry analysis |
GB2236184B (en) * | 1989-09-12 | 1993-07-28 | Finnigan Mat Ltd | Method of preparing samples for laser spectrometry analysis |
US5045694A (en) * | 1989-09-27 | 1991-09-03 | The Rockefeller University | Instrument and method for the laser desorption of ions in mass spectrometry |
US5029919A (en) * | 1990-02-15 | 1991-07-09 | Bauer John K | Pneumatic shock absorber for an automobile bumper having venting means |
US5073713A (en) | 1990-05-29 | 1991-12-17 | Battelle Memorial Institute | Detection method for dissociation of multiple-charged ions |
ATE118442T1 (en) * | 1990-06-08 | 1995-03-15 | Mannesmann Ag | SHELF SYSTEM. |
US5209919A (en) * | 1990-07-13 | 1993-05-11 | Regents Of The University Of California | Method of measurement in biological systems |
WO1992013629A1 (en) * | 1991-01-31 | 1992-08-20 | Wayne State University | A method for analyzing an organic sample |
US5171989A (en) * | 1992-01-24 | 1992-12-15 | Board Of Trustees Of Leland Stanford Jr. University | Method and apparatus for continuous sample ice matrix production for laser desorption in mass spectrometry |
US5317932A (en) * | 1992-02-28 | 1994-06-07 | The Dow Chemical Company | Sample probe |
EP1262564A3 (en) * | 1993-01-07 | 2004-03-31 | Sequenom, Inc. | Dna sequencing by mass spectrometry |
US5605798A (en) | 1993-01-07 | 1997-02-25 | Sequenom, Inc. | DNA diagnostic based on mass spectrometry |
CA2158642A1 (en) | 1993-03-19 | 1994-09-29 | Hubert Koster | Dna sequencing by mass spectrometry via exonuclease degradation |
US20020037517A1 (en) | 1993-05-28 | 2002-03-28 | Hutchens T. William | Methods for sequencing biopolymers |
US6020208A (en) * | 1994-05-27 | 2000-02-01 | Baylor College Of Medicine | Systems for surface-enhanced affinity capture for desorption and detection of analytes |
NZ267842A (en) * | 1993-05-28 | 1997-09-22 | Baylor College Medicine | Apparatus for measuring molecular mass (by mass spectrometry) in which the sample is ionised on the sample holder and desorbed therefrom by laser pulses |
WO1996037777A1 (en) * | 1995-05-23 | 1996-11-28 | Nelson Randall W | Mass spectrometric immunoassay |
ATE305969T1 (en) * | 1995-06-07 | 2005-10-15 | Univ Arizona | SAMPLER FOR MASS SPECTROMETRY |
NZ516848A (en) * | 1997-06-20 | 2004-03-26 | Ciphergen Biosystems Inc | Retentate chromatography apparatus with applications in biology and medicine |
US6228047B1 (en) * | 1997-07-28 | 2001-05-08 | 1274515 Ontario Inc. | Method and apparatus for performing peritoneal dialysis |
WO1999006833A1 (en) | 1997-07-29 | 1999-02-11 | Huston James S | Methods for obtaining probes of peptide function |
EP1173878B1 (en) | 1999-04-27 | 2011-04-06 | Bio-Rad Laboratories, Inc. | Probes for a gas phase ion spectrometer |
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