CA2511995A1 - Pharmaceutical preparations for treatments of diseases and disorders of the breast - Google Patents
Pharmaceutical preparations for treatments of diseases and disorders of the breast Download PDFInfo
- Publication number
- CA2511995A1 CA2511995A1 CA002511995A CA2511995A CA2511995A1 CA 2511995 A1 CA2511995 A1 CA 2511995A1 CA 002511995 A CA002511995 A CA 002511995A CA 2511995 A CA2511995 A CA 2511995A CA 2511995 A1 CA2511995 A1 CA 2511995A1
- Authority
- CA
- Canada
- Prior art keywords
- drug
- breast
- drug formulation
- group
- hormone
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 210000000481 breast Anatomy 0.000 title claims abstract 10
- 238000011282 treatment Methods 0.000 title claims 2
- 208000037765 diseases and disorders Diseases 0.000 title 1
- 239000000825 pharmaceutical preparation Substances 0.000 title 1
- 229940079593 drug Drugs 0.000 claims abstract 19
- 239000003814 drug Substances 0.000 claims abstract 19
- 239000013583 drug formulation Substances 0.000 claims abstract 12
- 210000004883 areola Anatomy 0.000 claims abstract 3
- 210000000038 chest Anatomy 0.000 claims abstract 3
- 239000006071 cream Substances 0.000 claims abstract 3
- 239000006260 foam Substances 0.000 claims abstract 3
- 239000006210 lotion Substances 0.000 claims abstract 3
- 238000000034 method Methods 0.000 claims 10
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 7
- 201000010099 disease Diseases 0.000 claims 5
- 108700012941 GNRH1 Proteins 0.000 claims 4
- 239000000579 Gonadotropin-Releasing Hormone Substances 0.000 claims 4
- NKANXQFJJICGDU-QPLCGJKRSA-N Tamoxifen Chemical class C=1C=CC=CC=1C(/CC)=C(C=1C=CC(OCCN(C)C)=CC=1)/C1=CC=CC=C1 NKANXQFJJICGDU-QPLCGJKRSA-N 0.000 claims 4
- 239000003795 chemical substances by application Substances 0.000 claims 4
- POZRVZJJTULAOH-LHZXLZLDSA-N danazol Chemical class C1[C@]2(C)[C@H]3CC[C@](C)([C@](CC4)(O)C#C)[C@@H]4[C@@H]3CCC2=CC2=C1C=NO2 POZRVZJJTULAOH-LHZXLZLDSA-N 0.000 claims 4
- 229960000766 danazol Drugs 0.000 claims 4
- 229940088597 hormone Drugs 0.000 claims 4
- 239000005556 hormone Substances 0.000 claims 4
- 206010006298 Breast pain Diseases 0.000 claims 2
- 241000195940 Bryophyta Species 0.000 claims 2
- 208000006662 Mastodynia Diseases 0.000 claims 2
- 239000000443 aerosol Substances 0.000 claims 2
- 230000000202 analgesic effect Effects 0.000 claims 2
- 229940046836 anti-estrogen Drugs 0.000 claims 2
- 230000001833 anti-estrogenic effect Effects 0.000 claims 2
- 230000003110 anti-inflammatory effect Effects 0.000 claims 2
- 230000001028 anti-proliverative effect Effects 0.000 claims 2
- 239000002246 antineoplastic agent Substances 0.000 claims 2
- OZVBMTJYIDMWIL-AYFBDAFISA-N bromocriptine Chemical class C1=CC(C=2[C@H](N(C)C[C@@H](C=2)C(=O)N[C@]2(C(=O)N3[C@H](C(N4CCC[C@H]4[C@]3(O)O2)=O)CC(C)C)C(C)C)C2)=C3C2=C(Br)NC3=C1 OZVBMTJYIDMWIL-AYFBDAFISA-N 0.000 claims 2
- 229960002802 bromocriptine Drugs 0.000 claims 2
- 229940127089 cytotoxic agent Drugs 0.000 claims 2
- 208000035475 disorder Diseases 0.000 claims 2
- 239000000839 emulsion Substances 0.000 claims 2
- 239000000328 estrogen antagonist Substances 0.000 claims 2
- 239000000499 gel Substances 0.000 claims 2
- 239000003668 hormone analog Substances 0.000 claims 2
- 239000007788 liquid Substances 0.000 claims 2
- 235000011929 mousse Nutrition 0.000 claims 2
- 239000002674 ointment Substances 0.000 claims 2
- 239000007921 spray Substances 0.000 claims 2
- 230000003637 steroidlike Effects 0.000 claims 2
- 229960001603 tamoxifen Drugs 0.000 claims 2
- 206010001233 Adenoma benign Diseases 0.000 claims 1
- 206010006261 Breast infections Diseases 0.000 claims 1
- 206010011219 Costochondritis Diseases 0.000 claims 1
- 208000007659 Fibroadenoma Diseases 0.000 claims 1
- 208000000571 Fibrocystic breast disease Diseases 0.000 claims 1
- 208000010191 Osteitis Deformans Diseases 0.000 claims 1
- 208000027868 Paget disease Diseases 0.000 claims 1
- 206010034902 Phlebitis superficial Diseases 0.000 claims 1
- 208000026317 Tietze syndrome Diseases 0.000 claims 1
- 239000007864 aqueous solution Substances 0.000 claims 1
- 201000003516 breast abscess Diseases 0.000 claims 1
- 201000003149 breast fibroadenoma Diseases 0.000 claims 1
- 208000011803 breast fibrocystic disease Diseases 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 208000027202 mammary Paget disease Diseases 0.000 claims 1
- 208000004396 mastitis Diseases 0.000 claims 1
- 210000002966 serum Anatomy 0.000 claims 1
- 238000007910 systemic administration Methods 0.000 claims 1
- 238000011200 topical administration Methods 0.000 claims 1
- 238000009472 formulation Methods 0.000 abstract 3
- 239000000203 mixture Substances 0.000 abstract 3
- 239000000546 pharmaceutical excipient Substances 0.000 abstract 2
- 238000010521 absorption reaction Methods 0.000 abstract 1
- 230000036765 blood level Effects 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 239000011859 microparticle Substances 0.000 abstract 1
- 239000002105 nanoparticle Substances 0.000 abstract 1
- 210000002445 nipple Anatomy 0.000 abstract 1
- 230000009885 systemic effect Effects 0.000 abstract 1
- 230000000699 topical effect Effects 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0041—Mammary glands, e.g. breasts, udder; Intramammary administration
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0014—Skin, i.e. galenical aspects of topical compositions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/14—Drugs for genital or sexual disorders; Contraceptives for lactation disorders, e.g. galactorrhoea
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
- A61P5/32—Antioestrogens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
Abstract
Formulations for topical or local administration of drugs directly to the breast or chest to produce a regional or local effect with lower systemic dr ug levels than when an effective amount is administered systemically are disclosed herein. In a preferred embodiment, the drug is administered to the surface of the breast, areola, or directly to the nipple. The formulations provide increased patient comfort, increased bioavailability and relatively high blood levels in the region to be treated with a reduction of side effec ts compared to those administered systemically. The preferred formulations contain drugs in the form of micro or nanoparticles, which may be formed of drug alone or in combination with an excipient or carrier. The excipient or carrier may modify the release rates or enhance absorption into the affected area. The drug formulation may be in the form of a cream, lotion of foam.</S DOAB>
Claims (19)
1. A drug formulation comprising a drug in an amount effective to provide relief from diseases or disorders of the breast in a pharmaceutically acceptable carrier for topical administration to the breast, wherein the drug is not a non-steroidal antiinflammatory or analgesic.
2. The drug formulation of claim 1 wherein the drug is soluble in aqueous solutions.
3. The drug formulation of claim 1 wherein the drug is in the form of micro- or nano-particulates.
4. The drug formulation of claim 1 wherein the carrier is selected from the group consisting of a gel, ointment, lotion, emulsion, cream, foam, mousse, liquid, spray, and aerosol.
5. The drug formulation of claim 4, wherein the carrier is a hydroalcoholic gel.
6. The drug formulation of claim 1 wherein the drug is selected from the group consisting of chemotherapeutic agents, hormones, hormone releasing agents, hormone analogs, and anti-proliferative agents.
7. The drug formulation of claim 6 wherein the drug is selected from the group consisting of danazol, bromocriptine, tamoxifen, luteinizing hormone-releasing hormone (LHRH) analogues, and antiestrogens.
8. The drug formulation of claim 6 wherein the drug is a danazol.
9. The drug formulation of claim 1 in a dosage effective to treat benign diseases of the breast.
10. A method for treating a disease or disorder of the of the breast, chest or underlying musculature comprising topically administering to the patient a drug formulation suitable for local or regional delivery comprising an effective amount of drug to provide symptomatic relief, wherein the drug is not a non-steroidal antiinflammatory or analgesic, in a dosage which results in low serum drug levels as compared to the systemic administration of the drug.
11. The method of claim 10 wherein the drug is in the form of micro-or nano-particulates.
12. The method of claim 10 wherein the carrier is selected from the group consisting of a gel, ointment, lotion, emulsion, cream, foam, mousse, liquid, spray, and aerosol.
13. The method of claim 10 wherein the drug is selected from the group consisting of chemotherapeutic agents, hormones, hormone releasing agents, hormone analogs, and anti-proliferative agents.
14. The method of claim 13 wherein the drug is selected from the group consisting of danazol, bromocriptine, tamoxifen, luteinizing hormone-releasing hormone (LHRH) analogues, and antiestrogens.
15. The method of claim 13 wherein the drug is danazol.
16. The method of claim 10 in a dosage effective to a benign disease of the breast.
17. The method of claim 16 wherein the benign disease of the breast is selected from the group consisting of mastalgia, mastodynia, Mondor's disease, fibrocystic breast disease, costochondritis, mastitis, Paget's disease of the areola, fibroadenoma, breast abscess, and breast infections.
18. The method of claim 10 wherein the drug formulation provides a dosage effective for regional treatment.
19. The method of claim 18 wherein the region is the breast, areola, and underlying musculature of the chest.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CA2764405A CA2764405A1 (en) | 2003-01-02 | 2004-01-02 | Pharmaceutical preparations for treatments of diseases and disorders of the breast |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US43777803P | 2003-01-02 | 2003-01-02 | |
| US60/437,778 | 2003-01-02 | ||
| PCT/US2004/000023 WO2004060322A2 (en) | 2003-01-02 | 2004-01-02 | Pharmaceutical preparations for treatments of diseases and disorders of the breast |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA2764405A Division CA2764405A1 (en) | 2003-01-02 | 2004-01-02 | Pharmaceutical preparations for treatments of diseases and disorders of the breast |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CA2511995A1 true CA2511995A1 (en) | 2004-07-22 |
| CA2511995C CA2511995C (en) | 2012-03-13 |
Family
ID=32713228
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA2511995A Expired - Lifetime CA2511995C (en) | 2003-01-02 | 2004-01-02 | Pharmaceutical preparations for treatments of diseases and disorders of the breast |
| CA2764405A Abandoned CA2764405A1 (en) | 2003-01-02 | 2004-01-02 | Pharmaceutical preparations for treatments of diseases and disorders of the breast |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA2764405A Abandoned CA2764405A1 (en) | 2003-01-02 | 2004-01-02 | Pharmaceutical preparations for treatments of diseases and disorders of the breast |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US7812010B2 (en) |
| EP (1) | EP1578421A4 (en) |
| JP (2) | JP2006515026A (en) |
| AU (1) | AU2004203700B2 (en) |
| CA (2) | CA2511995C (en) |
| MX (1) | MXPA05007266A (en) |
| WO (1) | WO2004060322A2 (en) |
Families Citing this family (46)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8512718B2 (en) | 2000-07-03 | 2013-08-20 | Foamix Ltd. | Pharmaceutical composition for topical application |
| WO2003053292A1 (en) * | 2001-12-20 | 2003-07-03 | Femmepharma, Inc. | Vaginal delivery of drugs |
| WO2004037225A2 (en) | 2002-10-25 | 2004-05-06 | Foamix Ltd. | Cosmetic and pharmaceutical foam |
| IL152486A0 (en) | 2002-10-25 | 2003-05-29 | Meir Eini | Alcohol-free cosmetic and pharmaceutical foam carrier |
| US8119150B2 (en) | 2002-10-25 | 2012-02-21 | Foamix Ltd. | Non-flammable insecticide composition and uses thereof |
| US20080138296A1 (en) | 2002-10-25 | 2008-06-12 | Foamix Ltd. | Foam prepared from nanoemulsions and uses |
| US7704518B2 (en) | 2003-08-04 | 2010-04-27 | Foamix, Ltd. | Foamable vehicle and pharmaceutical compositions thereof |
| US10117812B2 (en) | 2002-10-25 | 2018-11-06 | Foamix Pharmaceuticals Ltd. | Foamable composition combining a polar solvent and a hydrophobic carrier |
| US7820145B2 (en) | 2003-08-04 | 2010-10-26 | Foamix Ltd. | Oleaginous pharmaceutical and cosmetic foam |
| US8900554B2 (en) | 2002-10-25 | 2014-12-02 | Foamix Pharmaceuticals Ltd. | Foamable composition and uses thereof |
| US9265725B2 (en) | 2002-10-25 | 2016-02-23 | Foamix Pharmaceuticals Ltd. | Dicarboxylic acid foamable vehicle and pharmaceutical compositions thereof |
| US9211259B2 (en) | 2002-11-29 | 2015-12-15 | Foamix Pharmaceuticals Ltd. | Antibiotic kit and composition and uses thereof |
| US8486376B2 (en) | 2002-10-25 | 2013-07-16 | Foamix Ltd. | Moisturizing foam containing lanolin |
| US8119109B2 (en) | 2002-10-25 | 2012-02-21 | Foamix Ltd. | Foamable compositions, kits and methods for hyperhidrosis |
| US7700076B2 (en) | 2002-10-25 | 2010-04-20 | Foamix, Ltd. | Penetrating pharmaceutical foam |
| US9668972B2 (en) | 2002-10-25 | 2017-06-06 | Foamix Pharmaceuticals Ltd. | Nonsteroidal immunomodulating kit and composition and uses thereof |
| US9173836B2 (en) * | 2003-01-02 | 2015-11-03 | FemmeParma Holding Company, Inc. | Pharmaceutical preparations for treatments of diseases and disorders of the breast |
| WO2004060322A2 (en) | 2003-01-02 | 2004-07-22 | Femmepharma Holding Company, Inc. | Pharmaceutical preparations for treatments of diseases and disorders of the breast |
| US7575739B2 (en) | 2003-04-28 | 2009-08-18 | Foamix Ltd. | Foamable iodine composition |
| US8486374B2 (en) | 2003-08-04 | 2013-07-16 | Foamix Ltd. | Hydrophilic, non-aqueous pharmaceutical carriers and compositions and uses |
| US8795693B2 (en) | 2003-08-04 | 2014-08-05 | Foamix Ltd. | Compositions with modulating agents |
| GB2420281A (en) * | 2004-11-22 | 2006-05-24 | Stegram Pharmaceuticals Ltd | Topical formulations for use in the treatment or prevention of dermatological conditions |
| GB2421183A (en) * | 2004-12-17 | 2006-06-21 | Stegram Pharmaceuticals Ltd | Topical formulations for use in the treatment or prevention of skin cancers |
| ES2447025T3 (en) * | 2005-07-12 | 2014-03-11 | Ampio Pharmaceuticals, Inc. | Methods and products for the treatment of diseases |
| JP4000185B2 (en) * | 2005-10-12 | 2007-10-31 | 興和株式会社 | Iontophoresis preparation for the treatment of breast cancer and / or mastitis |
| US20080260655A1 (en) | 2006-11-14 | 2008-10-23 | Dov Tamarkin | Substantially non-aqueous foamable petrolatum based pharmaceutical and cosmetic compositions and their uses |
| EP2104489A2 (en) * | 2006-12-26 | 2009-09-30 | FemmePharma Holding Company, Inc. | Topical administration of danazol |
| US8636982B2 (en) | 2007-08-07 | 2014-01-28 | Foamix Ltd. | Wax foamable vehicle and pharmaceutical compositions thereof |
| US9439857B2 (en) | 2007-11-30 | 2016-09-13 | Foamix Pharmaceuticals Ltd. | Foam containing benzoyl peroxide |
| WO2010041141A2 (en) | 2008-10-07 | 2010-04-15 | Foamix Ltd. | Oil-based foamable carriers and formulations |
| WO2009072007A2 (en) | 2007-12-07 | 2009-06-11 | Foamix Ltd. | Carriers, formulations, methods for formulating unstable active agents for external application and uses thereof |
| EP2242476A2 (en) | 2008-01-14 | 2010-10-27 | Foamix Ltd. | Poloxamer foamable pharmaceutical compositions with active agents and/or therapeutic cells and uses |
| JP2011135904A (en) | 2008-04-18 | 2011-07-14 | Kowa Co | Iontophoresis preparation for treating breast cancer and/or mastitis |
| EP2147674A1 (en) * | 2008-07-24 | 2010-01-27 | Besins Healthcare | Transdermal pharmaceutical compositions comprising danazol |
| CA2760186C (en) | 2009-04-28 | 2019-10-29 | Foamix Ltd. | Foamable vehicle and pharmaceutical compositions comprising aprotic polar solvents and uses thereof |
| PL2554173T3 (en) | 2009-06-22 | 2017-06-30 | Ampio Pharmaceuticals, Inc. | Method for treatment of diseases |
| US20110003000A1 (en) * | 2009-07-06 | 2011-01-06 | Femmepharma Holding Company, Inc. | Transvaginal Delivery of Drugs |
| CA2769625C (en) | 2009-07-29 | 2017-04-11 | Foamix Ltd. | Non surfactant hydro-alcoholic foamable compositions, breakable foams and their uses |
| CA2769677A1 (en) | 2009-07-29 | 2011-02-03 | Foamix Ltd. | Non surface active agent non polymeric agent hydro-alcoholic foamable compositions, breakable foams and their uses |
| US8945516B2 (en) | 2009-10-02 | 2015-02-03 | Foamix Pharmaceuticals Ltd. | Surfactant-free water-free foamable compositions, breakable foams and gels and their uses |
| US9849142B2 (en) | 2009-10-02 | 2017-12-26 | Foamix Pharmaceuticals Ltd. | Methods for accelerated return of skin integrity and for the treatment of impetigo |
| US8174881B2 (en) | 2009-11-24 | 2012-05-08 | Micron Technology, Inc. | Techniques for reducing disturbance in a semiconductor device |
| EP2934546A4 (en) | 2012-12-19 | 2016-06-22 | Ampio Pharmaceuticals Inc | Method for treatment of diseases |
| CA2978573A1 (en) | 2016-09-08 | 2018-03-08 | Foamix Pharmaceuticals Ltd. | Compositions and methods for treating rosacea and acne |
| WO2018093369A1 (en) * | 2016-11-17 | 2018-05-24 | Goren Ofer A | Treatment of sexual dysfunction and for improved sexual quality of life |
| BR112022015321A2 (en) * | 2020-02-03 | 2022-09-20 | Curemast Inc | COMPOSITION AND METHOD FOR TREATMENT OF MASTITIS AND METHOD OF TREATMENT OF MASTITIS IN A DAIRY COW OR GOAT |
Family Cites Families (98)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB767824A (en) | 1954-07-29 | 1957-02-06 | Organon Labor Ltd | Improvements in preparations for the treatment of the human skin |
| US3927216A (en) * | 1971-06-01 | 1975-12-16 | Icn Pharmaceuticals | 1,2,4-Triazol E-3-carboxamides for inhibiting virus infections |
| US3921636A (en) * | 1973-01-15 | 1975-11-25 | Alza Corp | Novel drug delivery device |
| US4107288A (en) * | 1974-09-18 | 1978-08-15 | Pharmaceutical Society Of Victoria | Injectable compositions, nanoparticles useful therein, and process of manufacturing same |
| US4081533A (en) * | 1976-09-01 | 1978-03-28 | Regents Of The University Of California | Method of reducing mammalian fertility and drugs therefor |
| US4391797A (en) * | 1977-01-05 | 1983-07-05 | The Children's Hospital Medical Center | Systems for the controlled release of macromolecules |
| US4291028A (en) * | 1977-12-30 | 1981-09-22 | Nichols Vorys | Follicular phase estrogen or progestin with physiologic estrogen/progestin luteal phase replacement drug delivery system |
| US4292315A (en) * | 1977-12-30 | 1981-09-29 | Nichols Vorys | Follicular phase estrogen or progestin with physiologic estrogen/progestin luteal phase replacement drug delivery system |
| US4272398A (en) * | 1978-08-17 | 1981-06-09 | The United States Of America As Represented By The Secretary Of Agriculture | Microencapsulation process |
| US4286587A (en) * | 1978-10-11 | 1981-09-01 | Alza Corporation | Vaginal drug delivery system made from polymer |
| US4756907A (en) * | 1978-10-17 | 1988-07-12 | Stolle Research & Development Corp. | Active/passive immunization of the internal female reproductive organs |
| DE3214667C2 (en) * | 1982-04-21 | 1985-07-18 | Akzo Gmbh, 5600 Wuppertal | Composite body for the long-term delivery of active ingredients |
| US4524359A (en) * | 1982-07-23 | 1985-06-18 | The United States Of America As Represented By The Secretary Of The Air Force | Radar system for reducing angle tracking errors |
| US4588724A (en) * | 1982-12-10 | 1986-05-13 | Greenway Frank L Iii | Treatment for selective reduction of regional fat deposits |
| US4673405A (en) * | 1983-03-04 | 1987-06-16 | Alza Corporation | Osmotic system with instant drug availability |
| US4591496A (en) * | 1984-01-16 | 1986-05-27 | Massachusetts Institute Of Technology | Process for making systems for the controlled release of macromolecules |
| FR2558373B1 (en) | 1984-01-20 | 1987-07-03 | Mauvais Jarvis Pierre | ANTI-ESTROGEN MEDICINAL PRODUCT BASED ON 4-HYDROXYTAMOXIFENE FOR PERCUTANEOUS ADMINISTRATION |
| NL8401912A (en) * | 1984-06-15 | 1986-01-02 | Tno | BIODEGRADABLE POLYMER SUBSTRATES LOADED WITH ACTIVE SUBSTANCE, SUITABLE FOR THE CONTROLLED DELIVERY OF THE ACTIVE SUBSTANCE BY MEMBRANE. |
| JPS6163615A (en) * | 1984-09-05 | 1986-04-01 | Shunichi Naito | Antiphlogistic analgesic |
| US4826830A (en) * | 1985-07-31 | 1989-05-02 | Jui Han | Topical application of glyciphosphoramide |
| JPS62187415A (en) * | 1986-02-12 | 1987-08-15 | Lion Corp | Composition for promoting transcutaneous absorption |
| US4762717A (en) * | 1986-03-21 | 1988-08-09 | The General Hospital Corporation | Continuous delivery of luteinizing hormone releasing hormone compositions in combination with sex steroid delivery for use as a contraceptive |
| US4919939A (en) * | 1986-04-29 | 1990-04-24 | Pharmetrix Corporation | Periodontal disease treatment system |
| US5057317A (en) * | 1987-03-24 | 1991-10-15 | Chugai Seiyaku Kabushiki Kaisha | Slow-release pharmaceutical agent |
| US4861627A (en) * | 1987-05-01 | 1989-08-29 | Massachusetts Institute Of Technology | Preparation of multiwall polymeric microcapsules |
| US4873092A (en) * | 1987-05-21 | 1989-10-10 | Murata Kikai Kabushiki Kaisha | Slow-releasing preparation |
| JP2590358B2 (en) * | 1988-03-01 | 1997-03-12 | 正雄 五十嵐 | In utero or vaginal administration preparation for endometriosis treatment |
| US4945103A (en) | 1989-01-17 | 1990-07-31 | Michael Cohen | Method of treating pre-menstrual syndrome |
| IT1235053B (en) * | 1989-04-07 | 1992-06-17 | Poli Ind Chimica Spa | METHODS FOR THE PREPARATION OF PHARMACEUTICAL COMPOSITIONS BASED ON BROMOCRIPTINE EQUIPPED WITH HIGH STABILITY AND DERIVING PRODUCTS. |
| US5130137A (en) * | 1989-08-09 | 1992-07-14 | The General Hospital Corporation | Continuous delivery of luteinizing hormone releasing hormone compositions in combination with sex steroid delivery for use in treating benign ovarian secretory disorders |
| US5580857A (en) * | 1989-12-12 | 1996-12-03 | Oden; Per | Use of gibberellins for the treatment of prostatitis |
| FR2663224B1 (en) * | 1990-06-14 | 1995-01-20 | Applicationes Farmaceuticas Sa | PARENTERAL GALENIC FORM. |
| US5091185A (en) * | 1990-06-20 | 1992-02-25 | Monsanto Company | Coated veterinary implants |
| US5156851A (en) * | 1990-06-20 | 1992-10-20 | Monsanto Company | Coated veterinary implants |
| FR2669537B1 (en) * | 1990-11-28 | 1993-02-19 | Oreal | SLIMMING COMPOSITION BASED ON ALPHA-2-BLOCKERS. |
| US5145684A (en) * | 1991-01-25 | 1992-09-08 | Sterling Drug Inc. | Surface modified drug nanoparticles |
| US5552160A (en) * | 1991-01-25 | 1996-09-03 | Nanosystems L.L.C. | Surface modified NSAID nanoparticles |
| WO1992014449A1 (en) * | 1991-02-20 | 1992-09-03 | Nova Pharmaceutical Corporation | Controlled release microparticulate delivery system for proteins |
| JPH0735335B2 (en) | 1991-02-28 | 1995-04-19 | 五十嵐 正雄 | Remedy for endometriosis |
| US5340585A (en) * | 1991-04-12 | 1994-08-23 | University Of Southern California | Method and formulations for use in treating benign gynecological disorders |
| IT1250421B (en) * | 1991-05-30 | 1995-04-07 | Recordati Chem Pharm | CONTROLLED RELEASE PHARMACEUTICAL COMPOSITION WITH BIO-ADHESIVE PROPERTIES. |
| HU222501B1 (en) * | 1991-06-28 | 2003-07-28 | Endorecherche Inc. | Controlled release pharmaceutical composition containing mpa or mga and process for its preparation |
| ZA924811B (en) * | 1991-06-28 | 1993-12-29 | Endorecherche Inc | Controlled release systems and low dose androgens |
| US5330768A (en) * | 1991-07-05 | 1994-07-19 | Massachusetts Institute Of Technology | Controlled drug delivery using polymer/pluronic blends |
| EP0550108B1 (en) * | 1991-12-30 | 1998-03-18 | Akzo Nobel N.V. | Sustained release thyroactive composition |
| ATE154240T1 (en) * | 1992-03-12 | 1997-06-15 | Alkermes Inc | ACTH CONTAINING MICRO SPHERES WITH CONTROLLED RELEASE |
| US5614212A (en) * | 1992-04-08 | 1997-03-25 | International Medical Associates, Inc. | Method of transdermally administering high molecular weight drugs with a polymer skin enhancer |
| CA2094217A1 (en) | 1992-04-17 | 1993-10-18 | Yasutaka Igari | Transmucosal therapeutic composition |
| CA2114968A1 (en) * | 1993-02-25 | 1994-08-26 | John Wille | Transdermal treatment with mast cell degranulating agents for drug-induced hypersensitivity |
| US5359030A (en) * | 1993-05-10 | 1994-10-25 | Protein Delivery, Inc. | Conjugation-stabilized polypeptide compositions, therapeutic delivery and diagnostic formulations comprising same, and method of making and using the same |
| US5651976A (en) * | 1993-06-17 | 1997-07-29 | The United States Of America As Represented By The Secretary Of The Navy | Controlled release of active agents using inorganic tubules |
| GB9318641D0 (en) | 1993-09-08 | 1993-10-27 | Edko Trading Representation | Compositions |
| US5417982A (en) * | 1994-02-17 | 1995-05-23 | Modi; Pankaj | Controlled release of drugs or hormones in biodegradable polymer microspheres |
| NL9400410A (en) * | 1994-03-16 | 1995-11-01 | M D Ph D Willem Arthur Adriaan | Intrauterine contraceptive. |
| US5482925A (en) * | 1994-03-17 | 1996-01-09 | Comedicus Incorporated | Complexes of nitric oxide with cardiovascular amines as dual acting cardiovascular agents |
| US5718388A (en) | 1994-05-25 | 1998-02-17 | Eastman Kodak | Continuous method of grinding pharmaceutical substances |
| TW384224B (en) | 1994-05-25 | 2000-03-11 | Nano Sys Llc | Method of preparing submicron particles of a therapeutic or diagnostic agent |
| US5587143A (en) | 1994-06-28 | 1996-12-24 | Nanosystems L.L.C. | Butylene oxide-ethylene oxide block copolymer surfactants as stabilizer coatings for nanoparticle compositions |
| US5633011A (en) * | 1994-08-04 | 1997-05-27 | Alza Corporation | Progesterone replacement therapy |
| US5573783A (en) | 1995-02-13 | 1996-11-12 | Nano Systems L.L.C. | Redispersible nanoparticulate film matrices with protective overcoats |
| US5510118A (en) * | 1995-02-14 | 1996-04-23 | Nanosystems Llc | Process for preparing therapeutic compositions containing nanoparticles |
| US5660835A (en) * | 1995-02-24 | 1997-08-26 | East Carolina University | Method of treating adenosine depletion |
| US5536499A (en) * | 1995-02-24 | 1996-07-16 | Chesebrough-Pond's Usa Co., Division Of Conopco, Inc. | Cosmetic compositions for reducing or preventing signs of cellulite |
| ES2093562B1 (en) | 1995-05-26 | 1997-07-01 | Univ Santiago Compostela | STABILIZATION OF COLLOID SYSTEMS THROUGH FORMATION OF LIPIDO-POLISACARIDO IONIC COMPLEXES. |
| US5705170A (en) * | 1995-10-24 | 1998-01-06 | Plantech International, Inc. | Herbal cellulite treatments |
| US5789442A (en) * | 1996-01-18 | 1998-08-04 | Schering Aktiengesellschaft | Treatment of urinary incontinence with nitric oxide synthase substrates and/or nitric oxide donors alone or in combination with estrogen or progesterone and/or other agents |
| AUPN814496A0 (en) * | 1996-02-19 | 1996-03-14 | Monash University | Dermal penetration enhancer |
| WO1997036570A1 (en) * | 1996-03-29 | 1997-10-09 | S.W. Patentverwertungs Ges. M.B.H. Edelsbacher U. Partner | Cosmetic or cosmetic preparation for smoothing and tightening the skin in the case of subcutaneous fatty tissue problems, particularly cellulite |
| US5778894A (en) * | 1996-04-18 | 1998-07-14 | Elizabeth Arden Co. | Method for reducing human body cellulite by treatment with pulsed electromagnetic energy |
| AU4421697A (en) | 1996-09-19 | 1998-04-14 | American Home Products Corporation | Method of treating urinary incontinence |
| US6416778B1 (en) * | 1997-01-24 | 2002-07-09 | Femmepharma | Pharmaceutical preparations and methods for their regional administration |
| US5993856A (en) * | 1997-01-24 | 1999-11-30 | Femmepharma | Pharmaceutical preparations and methods for their administration |
| US6071526A (en) * | 1997-03-27 | 2000-06-06 | S.W. Patentverwertungs Ges M.B. H. | Cosmetic or cosmetic product for firming and soothing the skin in particular in the case of cellulite |
| DK1510213T3 (en) | 1997-11-10 | 2009-03-23 | Strakan Int Ltd | Penetration-enhancing and irritation-reducing systems including testosterone |
| DE19830732B4 (en) * | 1998-07-09 | 2008-11-13 | Lts Lohmann Therapie-Systeme Ag | Composition containing at least one substance influencing blood lipid levels and its use |
| CA2313789A1 (en) * | 1998-07-16 | 2000-01-27 | Aaron Tabor | Soy formulations and their use for promoting health |
| SE9802864D0 (en) * | 1998-08-27 | 1998-08-27 | Pharmacia & Upjohn Ab | Transdermally administered tolterodine as an antimuscarinic agent for the treatment of overactive bladder |
| AU759016B2 (en) * | 1998-10-05 | 2003-04-03 | Penn State Research Foundation, The | Compositions and methods for enhancing receptor-mediated cellular internalization |
| JP2000143540A (en) | 1998-11-06 | 2000-05-23 | Bristol Myers Squibb Co | External preparation containing non-steroidal anti- inflammatory drug |
| AU5460800A (en) * | 1999-06-02 | 2000-12-18 | Aviana Biopharm | Pharmaceutical transdermal compositions |
| US6358539B1 (en) * | 1999-08-20 | 2002-03-19 | Howard Murad | Pharmaceutical compositions for reducing the appearance of cellulite |
| WO2001019868A1 (en) * | 1999-09-15 | 2001-03-22 | Mogam Biotechnology Research Institute | A novel angiogenesis inhibitor |
| US20030153585A1 (en) * | 2000-01-13 | 2003-08-14 | Sven-Alexander Schreder | Pharmaceutical preparations containing 2-pyrrolidone as the dissolving intermediary |
| US6436428B1 (en) * | 2000-03-21 | 2002-08-20 | Enhance Pharmaceuticals, Inc. | Device and method for treating urinary incontinence in females |
| PT1280486E (en) * | 2000-04-26 | 2011-02-28 | Watson Pharmaceuticals Inc | Minimizing adverse experience associated with oxybutynin therapy |
| US6503894B1 (en) | 2000-08-30 | 2003-01-07 | Unimed Pharmaceuticals, Inc. | Pharmaceutical composition and method for treating hypogonadism |
| DE10054294A1 (en) | 2000-11-02 | 2002-05-16 | Heinrich Wieland | Topical treatment for mastalgia |
| EP1249247B1 (en) * | 2001-03-30 | 2007-02-28 | Chisso Corporation | Pharmaceutical preparation for the treatment of gynecological diseases |
| DE10146541A1 (en) * | 2001-09-21 | 2003-04-17 | Kade Pharma Fab Gmbh | Medicinal products based on progestogens for dermal use |
| US20030175329A1 (en) * | 2001-10-04 | 2003-09-18 | Cellegy Pharmaceuticals, Inc. | Semisolid topical hormonal compositions and methods for treatment |
| WO2003039524A1 (en) | 2001-11-09 | 2003-05-15 | Pharmacia Ab | Anti-muscarinic agent and estrogen-agonist for treating unstable or overactive bladder |
| WO2003053292A1 (en) * | 2001-12-20 | 2003-07-03 | Femmepharma, Inc. | Vaginal delivery of drugs |
| US8476280B2 (en) * | 2002-05-09 | 2013-07-02 | Versi Group, Llc | Compositions and methods for combating lower urinary tract dysfunctions with delta opioid receptor agonists |
| JP4684655B2 (en) * | 2002-12-18 | 2011-05-18 | ラボラトワール ブザン アンテルナスィヨナル | Breast density reduction due to 4-hydroxy tamoxifen |
| WO2004060322A2 (en) | 2003-01-02 | 2004-07-22 | Femmepharma Holding Company, Inc. | Pharmaceutical preparations for treatments of diseases and disorders of the breast |
| US20050101579A1 (en) * | 2003-11-06 | 2005-05-12 | Shippen Eugene R. | Endometriosis treatment protocol |
| EP2104489A2 (en) * | 2006-12-26 | 2009-09-30 | FemmePharma Holding Company, Inc. | Topical administration of danazol |
| CA2688542C (en) * | 2007-05-30 | 2016-07-12 | Michael J. Martin | Methods and compositions for administration of oxybutynin |
-
2004
- 2004-01-02 WO PCT/US2004/000023 patent/WO2004060322A2/en active IP Right Grant
- 2004-01-02 MX MXPA05007266A patent/MXPA05007266A/en unknown
- 2004-01-02 AU AU2004203700A patent/AU2004203700B2/en not_active Ceased
- 2004-01-02 CA CA2511995A patent/CA2511995C/en not_active Expired - Lifetime
- 2004-01-02 CA CA2764405A patent/CA2764405A1/en not_active Abandoned
- 2004-01-02 EP EP04700078A patent/EP1578421A4/en not_active Withdrawn
- 2004-01-02 US US10/751,056 patent/US7812010B2/en active Active
- 2004-01-02 JP JP2005518791A patent/JP2006515026A/en active Pending
-
2009
- 2009-09-04 JP JP2009205375A patent/JP2009280627A/en active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| CA2764405A1 (en) | 2004-07-22 |
| AU2004203700B2 (en) | 2007-06-21 |
| AU2004203700A1 (en) | 2004-07-22 |
| WO2004060322A3 (en) | 2005-04-07 |
| JP2009280627A (en) | 2009-12-03 |
| JP2006515026A (en) | 2006-05-18 |
| MXPA05007266A (en) | 2006-01-17 |
| EP1578421A2 (en) | 2005-09-28 |
| US20040229813A1 (en) | 2004-11-18 |
| US7812010B2 (en) | 2010-10-12 |
| EP1578421A4 (en) | 2009-04-22 |
| WO2004060322A2 (en) | 2004-07-22 |
| CA2511995C (en) | 2012-03-13 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CA2511995A1 (en) | Pharmaceutical preparations for treatments of diseases and disorders of the breast | |
| KR101488025B1 (en) | Sprayable gel-type skin/mucosa-adhesive preparation and administration system using the preparation | |
| WO2003053292B1 (en) | Vaginal delivery of drugs | |
| ES2599973T3 (en) | A topical formulation of low-level clobetasol propionate to treat disorders of the mucous membrane and skin | |
| JP2011529038A5 (en) | ||
| WO2020043185A1 (en) | Application of amino acid nutrient, and pharmaceutical composition including amino acid nutrient | |
| US20140011838A1 (en) | Compositions and methods for treating warts associated with viral infections | |
| WO2013098675A1 (en) | Compositions for the treatment of mucous membrane diseases | |
| CN112438942A (en) | Pharmaceutical composition containing alkalizer and its synergist and its application | |
| Prajapati et al. | The review on the nasal drug delivery | |
| Pagano et al. | Novel Approaches in Nasal In Situ Gel Drug Delivery | |
| CN112439066A (en) | Pharmaceutical composition comprising chemical ablation agent and pH adjusting agent and use thereof | |
| Ruby et al. | Antiemetic drugs as a nasal drug delivery-a review | |
| US6486152B1 (en) | Topical carbamazepine formulations and methods of use | |
| JP2000119186A (en) | Sucralfate-containing pharmaceutical composition for local administration | |
| Lansley et al. | Nasal drug delivery | |
| AU2007216882B2 (en) | Pharmaceutical preparations for treatment of diseases and disorders of the breast | |
| US20040248804A1 (en) | Nasal administration of the LH-RH analog Leuprolide | |
| WO2023137098A1 (en) | Compositions and methods for improving sexual sensory disorders | |
| CA3200753A1 (en) | A composition comprising fexofenadine | |
| BR102015024742A2 (en) | nontoxic, bioidentical and biodegradable hydrophilic composition based on micronized hyaluronic acid particles of microadhesive and carrier properties via transmucosal pathway, associated with hcg hormone, with application in sublingual aerosol spray system for weight loss treatment | |
| RU2011106753A (en) | METHODS FOR INTRODUCING TOPICAL ANTI-FUNGAL DRUGS FOR THE TREATMENT OF FUNGAL INFECTIONS | |
| CN104523658A (en) | Erdosteine powder inhalation and preparation method thereof |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EEER | Examination request | ||
| MKEX | Expiry |
Effective date: 20240102 |