CA2510324A1 - Intraocular implants - Google Patents
Intraocular implants Download PDFInfo
- Publication number
- CA2510324A1 CA2510324A1 CA002510324A CA2510324A CA2510324A1 CA 2510324 A1 CA2510324 A1 CA 2510324A1 CA 002510324 A CA002510324 A CA 002510324A CA 2510324 A CA2510324 A CA 2510324A CA 2510324 A1 CA2510324 A1 CA 2510324A1
- Authority
- CA
- Canada
- Prior art keywords
- lens
- providing
- intraocular implant
- capsule
- electronic display
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000007943 implant Substances 0.000 title claims 40
- 239000002775 capsule Substances 0.000 claims abstract 45
- 230000004438 eyesight Effects 0.000 claims abstract 19
- 210000001525 retina Anatomy 0.000 claims abstract 16
- 238000011144 upstream manufacturing Methods 0.000 claims abstract 10
- 238000000034 method Methods 0.000 claims 32
- 230000004377 improving vision Effects 0.000 claims 6
- 230000005540 biological transmission Effects 0.000 claims 5
- 230000003287 optical effect Effects 0.000 claims 5
- 210000004087 cornea Anatomy 0.000 claims 4
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F9/00—Methods or devices for treatment of the eyes; Devices for putting-in contact lenses; Devices to correct squinting; Apparatus to guide the blind; Protective devices for the eyes, carried on the body or in the hand
- A61F9/08—Devices or methods enabling eye-patients to replace direct visual perception by another kind of perception
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/14—Eye parts, e.g. lenses, corneal implants; Implanting instruments specially adapted therefor; Artificial eyes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/14—Eye parts, e.g. lenses, corneal implants; Implanting instruments specially adapted therefor; Artificial eyes
- A61F2/16—Intraocular lenses
- A61F2/1613—Intraocular lenses having special lens configurations, e.g. multipart lenses; having particular optical properties, e.g. pseudo-accommodative lenses, lenses having aberration corrections, diffractive lenses, lenses for variably absorbing electromagnetic radiation, lenses having variable focus
- A61F2/1648—Multipart lenses
- A61F2/1651—Multipart lenses comprising a telescope
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/18—Applying electric currents by contact electrodes
- A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
- A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
- A61N1/36046—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation of the eye
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/14—Eye parts, e.g. lenses, corneal implants; Implanting instruments specially adapted therefor; Artificial eyes
- A61F2/16—Intraocular lenses
- A61F2/1613—Intraocular lenses having special lens configurations, e.g. multipart lenses; having particular optical properties, e.g. pseudo-accommodative lenses, lenses having aberration corrections, diffractive lenses, lenses for variably absorbing electromagnetic radiation, lenses having variable focus
- A61F2/1648—Multipart lenses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2250/00—Special features of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
- A61F2250/0014—Special features of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof having different values of a given property or geometrical feature, e.g. mechanical property or material property, at different locations within the same prosthesis
- A61F2250/0053—Special features of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof having different values of a given property or geometrical feature, e.g. mechanical property or material property, at different locations within the same prosthesis differing in optical properties
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2250/00—Special features of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
- A61F2250/0058—Additional features; Implant or prostheses properties not otherwise provided for
- A61F2250/0069—Sealing means
Abstract
An artificial vision system including a sealed capsule (106) adapted for intraocular placement upstream of a retina, an electronic display (108) located within the sealed capsule and focusing optics (110) located within the sealed capsule and arranged for focusing an image on the electronic display onto the retina.
Claims (83)
1. An artificial vision system comprising:
a sealed capsule adapted for intraocular placement upstream of a retina;
an electronic display located within said sealed capsule; and focusing optics located within said sealed capsule and arranged for focusing an image on said electronic display onto the retina.
a sealed capsule adapted for intraocular placement upstream of a retina;
an electronic display located within said sealed capsule; and focusing optics located within said sealed capsule and arranged for focusing an image on said electronic display onto the retina.
2. An artificial vision system according to claim 1 and wherein said electronic display comprises an LCD display.
3. An artificial vision system according to claim l and also comprising electronic circuitry located within said sealed capsule for operating said electronic display, said electronic circuitry being located outside an optical path defined between said electronic display and said focusing optics.
4. An artificial vision system according to claim 3 and wherein said electronic circuitry comprises a wireless data receiver operative to receive image data for display on said electronic display.
5. An artificial vision system according to claim 3 and wherein said electronic circuitry comprises a wireless energy receiver for wirelessly receiving electrical energy for operating said electronic display.
6. An artificial vision system according to claim 4 and also comprising wireless image transmission functionality operative to transmit said image data to said wireless data receiver.
7. An artificial vision system according to claim 6 and wherein said wireless image transmission functionality includes at least one of RF and IR
image transmission functionality.
image transmission functionality.
8. An artificial vision system according, to claim 3 and wherein said electronic circuitry comprises an electrical power source for providing electrical energy for operating said electronic display.
9. An artificial vision system according to claim 8 and wherein said power source for providing electrical energy for operating said electronic display is a rechargeable power source.
10. An artificial vision system according to claim 8 and wherein said power source for providing electrical energy for operating said electronic display is a wirelessly rechargeable power source.
11. An artificial vision system according to claim 9 and wherein said power source for providing electrical energy for operating said electronic display is rechargeable using at least one of ultrasonic, electromagnetic and photovoltaic power source.
12. An artificial vision system according to claim 1 and also comprising an image acquirer for acquiring an image to be displayed on said electronic display.
13. An artificial vision system according to claim 12 and wherein said image acquirer is mounted onto eyeglasses.
14. An artificial vision system according to claim 1 and wherein said focusing optics comprises a single lens.
15. An artificial vision system according to claim 1 and wherein said focusing optics comprises multiple lenses.
16. A method for providing artificial vision comprising:
implanting a sealed capsule in a user's eye upstream of a retina, said sealed capsule incorporating an electronic display and focusing optics for focusing an image on said electronic display onto the retina;
acquiring image data; and transmitting said image data to said electronic display for display thereon.
implanting a sealed capsule in a user's eye upstream of a retina, said sealed capsule incorporating an electronic display and focusing optics for focusing an image on said electronic display onto the retina;
acquiring image data; and transmitting said image data to said electronic display for display thereon.
17. A method for providing artificial vision according to claim 16 and wherein said transmitting comprises wireless transmission to electronic circuitry located within said sealed capsule for operating said electronic display.
18. A method for providing artificial vision according to claim 16 and also comprising wirelessly transmitting electrical energy for operating said electronic display to a location inside said capsule.
19. An intraocular implant, for placement upstream of a retina, comprising:
a telescope body defining an optical path for light to pass therethrough;
at least one first lens and at least one second lens enclosed in said telescope body;
positioning means, for positioning at least one of said lenses along its optical axis relative to another at least one of said lenses, operative to focus objects located at multiple distances onto the retina; and mounting structure connected to said telescope body for mounting said implant in an eye.
a telescope body defining an optical path for light to pass therethrough;
at least one first lens and at least one second lens enclosed in said telescope body;
positioning means, for positioning at least one of said lenses along its optical axis relative to another at least one of said lenses, operative to focus objects located at multiple distances onto the retina; and mounting structure connected to said telescope body for mounting said implant in an eye.
20. An intraocular implant according to claim 19 and wherein said positioning means comprises a range finder.
21. An intraocular implant according to claim 19 and wherein said positioning means comprises a focus resolver.
22. An intraocular implant according to claim 19 and wherein said positioning means is responsive to a user input.
23. An intraocular implant according to claim 19 and wherein said positioning means comprises:
a mounting for at least one of said lenses;
at least one magnet; and at least one electromagnetic coil, interacting with said at least one magnet.
a mounting for at least one of said lenses;
at least one magnet; and at least one electromagnetic coil, interacting with said at least one magnet.
24. An intraocular implant according to claim 19 and wherein said positioning means is responsive to an input from an input device external to said telescope body.
25. An intraocular implant system comprising:
a sealed capsule comprising:
at least one negative lens; and at least one air bubble; and at least one positive lens located outside said sealed capsule.
a sealed capsule comprising:
at least one negative lens; and at least one air bubble; and at least one positive lens located outside said sealed capsule.
26. An intraocular implant system according to claim 25 and wherein said at least one positive lens comprises an eyeglass lens.
27. An intraocular implant system according to claim 25 and wherein said at least one positive lens comprises a contact lens.
28. An intraocular implant system according to claim 25 and wherein said at least one positive lens comprises a lens implanted in an eye.
29. An intraocular implant system according to claim 28 and wherein said implanted lens comprises an air capsule.
30. An intraocular implant system according to claim 25 and wherein an external wall of said sealed capsule comprises said at least one negative lens.
31. An intraocular implant system comprising:
a sealed capsule comprising:
at least one positive lens; and at least one air bubble; and at least one negative lens located outside said sealed capsule.
a sealed capsule comprising:
at least one positive lens; and at least one air bubble; and at least one negative lens located outside said sealed capsule.
32. An intraocular implant system according to claim 31 and wherein said at least one negative lens comprises an eyeglass lens.
33. An intraocular implant system according to claim 31 and wherein said at least one negative lens comprises a contact lens.
34. An intraocular implant system according to claim 31 and wherein said at least one negative lens comprises a lens implanted in an eye.
35. An intraocular implant system according to claim 34 and wherein said implanted lens comprises an air capsule.
36. An intraocular implant system according to claim 31 and wherein an external wall of said sealed capsule comprises said at least one positive lens.
37. An intraocular implant system for use in an environment wherein at least one negative lens is located outside the lens capsule of an eye, the system including a sealed capsule comprising:
at least one positive lens cooperating with said at least one negative lens to define a Galilean telescope; and at least one air bubble.
at least one positive lens cooperating with said at least one negative lens to define a Galilean telescope; and at least one air bubble.
38. An intraocular implant system according to claim 37 and wherein said at least one negative lens is produced by reshaping of the cornea.
39. An intraocular implant system according to claim 37 and wherein said at least one negative lens comprises an eyeglass lens.
40. An intraocular implant system according to claim 37 and wherein said at least one negative lens comprises a contact lens.
41. An intraocular implant system according to claim 37 and wherein said at least one negative lens comprises a lens implanted in an eye.
42. An intraocular implant system according to claim 41 and wherein said implanted lens comprises an air capsule.
43. An intraocular implant system according to claim 37 and wherein an external wall of said sealed capsule comprises said at least one positive lens.
44. An intraocular implant system for use in an environment wherein at least one positive lens is located outside the lens capsule of an eye, the system including a sealed capsule comprising:
at least one negative lens cooperating with said at least one positive lens to define a Galilean telescope; and at least one air bubble.
at least one negative lens cooperating with said at least one positive lens to define a Galilean telescope; and at least one air bubble.
45. ~An intraocular implant system according to claim 44 and wherein said at least one positive lens is produced by reshaping of the cornea.
46. An intraocular implant system according to claim 44 and wherein said at least one positive lens comprises an eyeglass lens.
47. An intraocular implant system according to claim 44 and wherein said at least one positive lens comprises a contact lens.
48. An intraocular implant system according to claim 44 and wherein said at least one positive lens comprises a lens implanted in an eye.
49. An intraocular implant system according to claim 48 and wherein said implanted lens comprises an air capsule.
50. An intraocular implant system according to claim 44 and wherein an external wall of said sealed capsule comprises said at least one negative lens.
51. A method of improving vision comprising:
implanting a sealed capsule upstream of a retina, said sealed capsule including an electronic display and focusing optics; and employing said electronic display and focusing optics for focusing an image appearing on said electronic display onto the retina.
implanting a sealed capsule upstream of a retina, said sealed capsule including an electronic display and focusing optics; and employing said electronic display and focusing optics for focusing an image appearing on said electronic display onto the retina.
52. A method according to claim 51 and also comprising:
employing a wireless data receiver operative to receive image data; and displaying said image data on said electronic display.
employing a wireless data receiver operative to receive image data; and displaying said image data on said electronic display.
53. A method according to claim 51 and also comprising employing a wireless energy receiver for wirelessly receiving electrical energy fox operating said electronic display.
54. A method according to claim 52 and also comprising wirelessly transmitting said image data to said wireless data receiver.
55. A method according to claim 54 and wherein said wirelessly transmitting includes wirelessly transmitting using at least one of RF and IR
image transmission functionality.
image transmission functionality.
56. A method according to claim 51 and also comprising employing an electrical power source for providing electrical energy for operating said electronic display.
57. A method according to claim 51 and also comprising acquiring an image to be displayed on said electronic display.
58. A method according to claim 57 and wherein said acquiring includes acquiring employing an image acquirer mounted onto eyeglasses.
59. A method of improving vision comprising:
providing an intraocular implant including a telescope body defining an optical path for light to pass therethrough, at least one first lens and at least one second lens enclosed in said telescope body, positioning means for positioning at least one of said lenses along its optical axis relative to another at least one of said lenses, operative to focus objects located at multiple distances onto a retina of an eye; and implanting said implant upstream of said retina.
providing an intraocular implant including a telescope body defining an optical path for light to pass therethrough, at least one first lens and at least one second lens enclosed in said telescope body, positioning means for positioning at least one of said lenses along its optical axis relative to another at least one of said lenses, operative to focus objects located at multiple distances onto a retina of an eye; and implanting said implant upstream of said retina.
60. A method according to claim 59 and also comprising:
providing an input to said positioning means; and positioning said at least one of said lenses in response to said input.
providing an input to said positioning means; and positioning said at least one of said lenses in response to said input.
61. A method according to claim 60 and wherein said providing an input comprises providing an input from an input device external to said telescope body.
62. A method of improving vision comprising:
implanting a sealed capsule upstream of a retina in an eye, said sealed capsule including at least one negative lens and at least one air bubble; and providing at least one positive lens located outside said sealed capsule.
implanting a sealed capsule upstream of a retina in an eye, said sealed capsule including at least one negative lens and at least one air bubble; and providing at least one positive lens located outside said sealed capsule.
63. A method according to claim 62 and wherein. said providing comprises providing an eyeglass lens.
64. An intraocular implant system according to claim 62 and wherein said providing comprises providing a contact lens.
65. An intraocular implant system according to claim 62 and wherein said providing comprises implanting a lens in said eye.
66. A method according to claim 65 and wherein said implanting a lens comprises implanting a lens including an air capsule.
67. A method of improving vision comprising:
implanting a sealed capsule upstream of a retina in an eye, said sealed capsule including at least one positive lens and at least one air bubble; and providing at least one negative lens located outside said sealed capsule.
implanting a sealed capsule upstream of a retina in an eye, said sealed capsule including at least one positive lens and at least one air bubble; and providing at least one negative lens located outside said sealed capsule.
68. A method according to claim 67 and wherein said wherein said providing comprises providing an eyeglass lens.
69. An intraocular implant system according to claim 67 and wherein said providing comprises providing a contact lens.
70. An intraocular implant system according to claim 67 and wherein said providing comprises implanting a lens in said eye.
71. A method according to claim 67 and wherein said implanting a lens comprises implanting a lens including an air capsule.
72. A method of improving vision comprising:
providing at least one negative lens located outside the lens capsule of an eye; and implanting a sealed capsule upstream of a retina in said eye, said sealed capsule including at least one air bubble and at least one positive lens cooperating with said at least one negative lens to define a Galilean telescope.
providing at least one negative lens located outside the lens capsule of an eye; and implanting a sealed capsule upstream of a retina in said eye, said sealed capsule including at least one air bubble and at least one positive lens cooperating with said at least one negative lens to define a Galilean telescope.
73. A method according to claim 72 and also comprising reshaping the cornea of said eye to produce said at least one negative lens.
74. A method according to claim 72 and wherein said providing comprises providing an eyeglass lens.
75. A method according to claim 72 and wherein said providing comprises providing a contact lens.
76. A method according to claim 72 and wherein said providing comprises implanting a lens in said eye.
77. A method according to claim 72 and wherein said implanting a lens comprises implanting a lens including an air capsule.
78. A method of improving vision comprising:
providing at least one positive lens located outside the lens capsule of an eye; and implanting a sealed capsule upstream of a retina in said eye, said sealed capsule including at least one air bubble and at least one negative lens cooperating with said at least one positive lens to define a Galilean telescope.
providing at least one positive lens located outside the lens capsule of an eye; and implanting a sealed capsule upstream of a retina in said eye, said sealed capsule including at least one air bubble and at least one negative lens cooperating with said at least one positive lens to define a Galilean telescope.
79. A method according to claim 78 and also comprising reshaping the cornea of said eye to produce said at least one positive lens.
80. A method according to claim 78 and wherein said providing comprises providing an eyeglass lens.
81. A method according to claim 78 and wherein said providing comprises providing a contact lens.
82. A method according to claim 78 and wherein said providing comprises implanting a lens in said eye.
83. A method according to claim 78 and wherein said implanting a lens comprises implanting a lens including an air capsule.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CA2759906A CA2759906C (en) | 2002-12-17 | 2003-12-17 | Intraocular implant including a variable positioner |
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US10/321,793 | 2002-12-17 | ||
US10/321,793 US7001427B2 (en) | 2002-12-17 | 2002-12-17 | Intraocular implants |
PCT/IL2003/001084 WO2004054469A2 (en) | 2002-12-17 | 2003-12-17 | Intraocular implants |
Related Child Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CA2759906A Division CA2759906C (en) | 2002-12-17 | 2003-12-17 | Intraocular implant including a variable positioner |
Publications (2)
Publication Number | Publication Date |
---|---|
CA2510324A1 true CA2510324A1 (en) | 2004-07-01 |
CA2510324C CA2510324C (en) | 2012-02-14 |
Family
ID=32507134
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CA2759906A Expired - Lifetime CA2759906C (en) | 2002-12-17 | 2003-12-17 | Intraocular implant including a variable positioner |
CA2510324A Expired - Lifetime CA2510324C (en) | 2002-12-17 | 2003-12-17 | Intraocular implants |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CA2759906A Expired - Lifetime CA2759906C (en) | 2002-12-17 | 2003-12-17 | Intraocular implant including a variable positioner |
Country Status (7)
Country | Link |
---|---|
US (6) | US7001427B2 (en) |
EP (1) | EP1585462B1 (en) |
JP (1) | JP2006509575A (en) |
AU (1) | AU2003288500A1 (en) |
CA (2) | CA2759906C (en) |
ES (1) | ES2623878T3 (en) |
WO (1) | WO2004054469A2 (en) |
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US20050222680A1 (en) | 2005-10-06 |
EP1585462A2 (en) | 2005-10-19 |
AU2003288500A1 (en) | 2004-07-09 |
WO2004054469A2 (en) | 2004-07-01 |
US20050154457A1 (en) | 2005-07-14 |
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