CA2505428A1 - Methods and apparatus for remodeling an extravascular tissue structure - Google Patents
Methods and apparatus for remodeling an extravascular tissue structure Download PDFInfo
- Publication number
- CA2505428A1 CA2505428A1 CA002505428A CA2505428A CA2505428A1 CA 2505428 A1 CA2505428 A1 CA 2505428A1 CA 002505428 A CA002505428 A CA 002505428A CA 2505428 A CA2505428 A CA 2505428A CA 2505428 A1 CA2505428 A1 CA 2505428A1
- Authority
- CA
- Canada
- Prior art keywords
- implant
- configuration
- medical apparatus
- forming element
- wall
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 238000007634 remodeling Methods 0.000 title claims abstract 9
- 238000000034 method Methods 0.000 title claims abstract 3
- 210000003748 coronary sinus Anatomy 0.000 claims abstract 7
- 210000004115 mitral valve Anatomy 0.000 claims abstract 2
- 239000007943 implant Substances 0.000 claims 12
- 230000004323 axial length Effects 0.000 claims 1
- 239000011248 coating agent Substances 0.000 claims 1
- 238000000576 coating method Methods 0.000 claims 1
- 230000008878 coupling Effects 0.000 claims 1
- 238000010168 coupling process Methods 0.000 claims 1
- 238000005859 coupling reaction Methods 0.000 claims 1
- 238000002513 implantation Methods 0.000 claims 1
- 238000004904 shortening Methods 0.000 claims 1
- 101100338513 Mus musculus Hdac9 gene Proteins 0.000 abstract 1
- 101100338514 Xenopus laevis hdac9 gene Proteins 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/24—Heart valves ; Vascular valves, e.g. venous valves; Heart implants, e.g. passive devices for improving the function of the native valve or the heart muscle; Transmyocardial revascularisation [TMR] devices; Valves implantable in the body
- A61F2/2442—Annuloplasty rings or inserts for correcting the valve shape; Implants for improving the function of a native heart valve
- A61F2/2451—Inserts in the coronary sinus for correcting the valve shape
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/24—Heart valves ; Vascular valves, e.g. venous valves; Heart implants, e.g. passive devices for improving the function of the native valve or the heart muscle; Transmyocardial revascularisation [TMR] devices; Valves implantable in the body
- A61F2/2442—Annuloplasty rings or inserts for correcting the valve shape; Implants for improving the function of a native heart valve
- A61F2/2466—Delivery devices therefor
Abstract
A medical apparatus and method for remodeling a mitral valve annulus adjacen t to the coronary sinus (22) includes an elongate body (40) having a proximal end (42) and a distal end (44). The elongate body (40) is movable from a first, flexible configuration for transluminal delivery to at least a portio n of the coronary sinus (22) to a second configuration for remodeling the mitr al valve annulus.
Claims (25)
1. A medical apparatus for remodeling a mitral valve annulus adjacent to the coronary sinus, comprising:
an elongate body, having a proximal end and a distal end, the elongate body being movable from a first, flexible configuration for transluminal delivery to at least a portion of the coronary sinus to a second configuration for remodeling the mural valve annulus; and a forming element attached to the elongate body for manipulating the elongate body from the first delivery configuration to the second remodeling configuration;
wherein the elongate body in the second, remodeling configuration comprises at least a first curve which is concave in a first direction and a second curve which is concave in a second direction.
an elongate body, having a proximal end and a distal end, the elongate body being movable from a first, flexible configuration for transluminal delivery to at least a portion of the coronary sinus to a second configuration for remodeling the mural valve annulus; and a forming element attached to the elongate body for manipulating the elongate body from the first delivery configuration to the second remodeling configuration;
wherein the elongate body in the second, remodeling configuration comprises at least a first curve which is concave in a first direction and a second curve which is concave in a second direction.
2. A medical apparatus as in Claim 1, wherein the body when in the second configuration comprises a third curve which is concave in the second direction.
3. A medical apparatus as in Claim 1 or 2, wherein the elongate body comprises a tube having a plurality of transverse slots therein.
4. A medical apparatus as in any one of the preceding claims, further comprising a lock for retaining the body in the second configuration.
5. A medical apparatus as in any one of the preceding claims, wherein the apparatus is movable from the delivery configuration to the remodeling configuration in response to proximal retraction of at least a portion of the forming element.
6. A medical apparatus as in any one of the preceding claims, wherein the apparatus is movable from the implantation configuration to the remodeling configuration in response to distal advancement of at least a portion of the forming element.
7. A medical apparatus as in any one of the preceding claims, wherein at least a first portion of the forming element extends within the body and a second portion of the forming element extends along the outside of the body.
8. A medical apparatus as in any one of the preceding claims, further comprising at least one anchor for engaging a site within a vessel.
9. A medical apparatus as in Claim 8, wherein the anchor comprises at least one barb for piercing the wall of the vessel.
10. A medical apparatus as in Claim 8, comprising a first tissue anchor at the proximal end and a second tissue anchor at the distal end.
11. A medical apparatus as in any one of the preceding claims, wherein the apparatus has an axial length of no more than about 10 cm.
12. A medical apparatus as in Claim 11, wherein the maximum cross sectional dimension through the apparatus is no more than about 10 mm.
13. An implant for positioning within a patient, comprising:
an elongate flexible body having a proximal section, a central section and a distal section;
a forming element extending through at least the proximal and distal sections of the body; and a detachable coupling on the body, for removably attaching the body to a deployment catheter;
wherein manipulation of the forming element deflects the central section laterally with respect to at least a portion of the proximal and distal sections.
an elongate flexible body having a proximal section, a central section and a distal section;
a forming element extending through at least the proximal and distal sections of the body; and a detachable coupling on the body, for removably attaching the body to a deployment catheter;
wherein manipulation of the forming element deflects the central section laterally with respect to at least a portion of the proximal and distal sections.
14. An implant as in Claim 13, wherein the body comprises a tubular wall.
15. An implant as in Claim 14, wherein the tubular wall is substantially noncompressible along a first side of the central section.
16. An implant as in Claim 15, comprising a plurality of voids in the wall along a second side of the central section, thereby permitting axial shortening or elongation of the second side.
17. An implant as in Claim 16 wherein at least some of the voids comprise slots through the wall, extending generally transverse to a longitudinal axis.
18. An implant as in Claim 17 comprising at least 10 transverse slots in the wall of the second side.
19. An implant as in Claim 18 comprising at least 20 transverse slots in the wall of the second side.
20. An implant as in Claim 13, wherein the forming element comprises an axially movable element.
21. An implant as in Claim 20, wherein the forming element comprises a pull wire.
22. An implant as in Claim 13, wherein manipulation of the forming element introduces a first curve in the central section of the body which is concave in a first direction, and at least a second curve in one of the proximal and distal sections of the body concave in a second direction.
23. An implant as in any one of the preceding claims, wherein manipulation of the forming element reshapes the body into a "w" configuration.
24. An implant as in any one of the preceding claims, further comprising a coating on the body.
25. A method of manipulating the mural valve, comprising the steps of:
providing a catheter, having a prosthesis thereon, the prosthesis having a first tissue anchor and a second tissue anchor;
inserting the catheter into the venous system;
transluminally advancing the prosthesis into the coronary sinus;
attaching the first and second tissue anchors to the wall of the coronary sinus; and manipulating the prosthesis to exert a lateral force on the wall of the coronary sinus in between the first and second tissue anchors.
providing a catheter, having a prosthesis thereon, the prosthesis having a first tissue anchor and a second tissue anchor;
inserting the catheter into the venous system;
transluminally advancing the prosthesis into the coronary sinus;
attaching the first and second tissue anchors to the wall of the coronary sinus; and manipulating the prosthesis to exert a lateral force on the wall of the coronary sinus in between the first and second tissue anchors.
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US42928102P | 2002-11-25 | 2002-11-25 | |
US60/429,281 | 2002-11-25 | ||
US10/634,655 US7011682B2 (en) | 2000-01-31 | 2003-08-05 | Methods and apparatus for remodeling an extravascular tissue structure |
US10/634,655 | 2003-08-05 | ||
PCT/US2003/037727 WO2004047677A2 (en) | 2002-11-25 | 2003-11-24 | Methods and apparatus for remodeling an extravascular tissue structure |
Publications (2)
Publication Number | Publication Date |
---|---|
CA2505428A1 true CA2505428A1 (en) | 2004-06-10 |
CA2505428C CA2505428C (en) | 2011-04-05 |
Family
ID=32397190
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CA2505428A Expired - Fee Related CA2505428C (en) | 2002-11-25 | 2003-11-24 | Methods and apparatus for remodeling an extravascular tissue structure |
Country Status (5)
Country | Link |
---|---|
US (4) | US7507252B2 (en) |
EP (1) | EP1572033B1 (en) |
AU (1) | AU2003295933B2 (en) |
CA (1) | CA2505428C (en) |
WO (1) | WO2004047677A2 (en) |
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-
2003
- 2003-08-05 US US10/634,653 patent/US7507252B2/en not_active Expired - Fee Related
- 2003-08-05 US US10/634,643 patent/US7296577B2/en not_active Expired - Fee Related
- 2003-08-05 US US10/634,655 patent/US7011682B2/en not_active Expired - Lifetime
- 2003-11-24 CA CA2505428A patent/CA2505428C/en not_active Expired - Fee Related
- 2003-11-24 AU AU2003295933A patent/AU2003295933B2/en not_active Ceased
- 2003-11-24 EP EP03787147A patent/EP1572033B1/en not_active Expired - Lifetime
- 2003-11-24 WO PCT/US2003/037727 patent/WO2004047677A2/en active Application Filing
-
2006
- 2006-01-13 US US11/331,671 patent/US20060116757A1/en not_active Abandoned
Also Published As
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AU2003295933A1 (en) | 2004-06-18 |
US20040153146A1 (en) | 2004-08-05 |
EP1572033B1 (en) | 2010-07-21 |
EP1572033A2 (en) | 2005-09-14 |
US20060116757A1 (en) | 2006-06-01 |
US20040133220A1 (en) | 2004-07-08 |
AU2003295933B2 (en) | 2009-05-21 |
US20040138744A1 (en) | 2004-07-15 |
CA2505428C (en) | 2011-04-05 |
WO2004047677A3 (en) | 2005-01-27 |
WO2004047677A2 (en) | 2004-06-10 |
US7011682B2 (en) | 2006-03-14 |
US7296577B2 (en) | 2007-11-20 |
EP1572033A4 (en) | 2008-08-13 |
US7507252B2 (en) | 2009-03-24 |
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