CA2503938C - Activatable bioactive vascular occlusive device - Google Patents

Activatable bioactive vascular occlusive device Download PDF

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Publication number
CA2503938C
CA2503938C CA2503938A CA2503938A CA2503938C CA 2503938 C CA2503938 C CA 2503938C CA 2503938 A CA2503938 A CA 2503938A CA 2503938 A CA2503938 A CA 2503938A CA 2503938 C CA2503938 C CA 2503938C
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CA
Canada
Prior art keywords
vascular occlusive
occlusive device
support member
thrombus inducing
fibers
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
CA2503938A
Other languages
French (fr)
Other versions
CA2503938A1 (en
Inventor
Juan A. Lorenzo
Mark L. Pomeranz
Darren Sherman
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Codman and Shurtleff Inc
Original Assignee
Cordis Neurovascular Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cordis Neurovascular Inc filed Critical Cordis Neurovascular Inc
Publication of CA2503938A1 publication Critical patent/CA2503938A1/en
Application granted granted Critical
Publication of CA2503938C publication Critical patent/CA2503938C/en
Active legal-status Critical Current
Anticipated expiration legal-status Critical

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/12—Surgical instruments, devices or methods, e.g. tourniquets for ligaturing or otherwise compressing tubular parts of the body, e.g. blood vessels, umbilical cord
    • A61B17/12022—Occluding by internal devices, e.g. balloons or releasable wires
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/12—Surgical instruments, devices or methods, e.g. tourniquets for ligaturing or otherwise compressing tubular parts of the body, e.g. blood vessels, umbilical cord
    • A61B17/12022—Occluding by internal devices, e.g. balloons or releasable wires
    • A61B17/12099—Occluding by internal devices, e.g. balloons or releasable wires characterised by the location of the occluder
    • A61B17/12109—Occluding by internal devices, e.g. balloons or releasable wires characterised by the location of the occluder in a blood vessel
    • A61B17/12113—Occluding by internal devices, e.g. balloons or releasable wires characterised by the location of the occluder in a blood vessel within an aneurysm
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/12—Surgical instruments, devices or methods, e.g. tourniquets for ligaturing or otherwise compressing tubular parts of the body, e.g. blood vessels, umbilical cord
    • A61B17/12022—Occluding by internal devices, e.g. balloons or releasable wires
    • A61B17/12131—Occluding by internal devices, e.g. balloons or releasable wires characterised by the type of occluding device
    • A61B17/1214—Coils or wires
    • A61B17/1215—Coils or wires comprising additional materials, e.g. thrombogenic, having filaments, having fibers, being coated
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
    • A61B2017/00004—(bio)absorbable, (bio)resorbable, resorptive
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/00234—Surgical instruments, devices or methods, e.g. tourniquets for minimally invasive surgery
    • A61B2017/00292—Surgical instruments, devices or methods, e.g. tourniquets for minimally invasive surgery mounted on or guided by flexible, e.g. catheter-like, means
    • A61B2017/00336—Surgical instruments, devices or methods, e.g. tourniquets for minimally invasive surgery mounted on or guided by flexible, e.g. catheter-like, means with a protective sleeve, e.g. retractable or slidable
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
    • A61B2017/00831—Material properties

Abstract

A vascular occlusive device, such as an embolic coil, having thrombogenic fibers extending from the coil and having an outer barrier which encapsulates and flattens the fibers along the sides of the embolic coil for preventing activation of the coil until the outer barrier has been dissolved, or removed, from the embolic coil.

Claims (19)

1. A vascular occlusive device comprising:
a support member;
a plurality of thrombogenic fibers mounted on said support member and having a first unconstrained position and a second constrained position; and, an outer barrier disposed over said plurality of thrombogenic fibers for normally constraining said thrombogenic fibers in the second constrained position, said outer barrier exhibiting the characteristic of dissolving when exposed to bodily fluids to thereby release said thrombogenic fibers to permit said thrombogenic fibers to return to the first unconstrained position to thereby react with bodily fluids in order to cause tissue ingrowth.
2. A vascular occlusive device as defined in Claim 1, wherein the support member is a vascular occlusive embolic coil.
3. A vascular occlusive device as defined in Claim 2, wherein the support member takes the form of a helically wound metallic coil.
4. A vascular occlusive device as defined in Claim 1, wherein the fibers normally extend outwardly from the surface of said support member.
5. A vascular occlusive device as defined in Claim 4, wherein the outer barrier retains the plurality of fibers in a flattened configuration along a surface of the support member.
6. A vascular occlusive device comprising:
a support member;
a thrombus inducing member disposed on said support member and having a first unconstrained position and a second constrained position; and, an outer barrier disposed on said thrombus inducing member for normally constraining said thrombus inducing member in the second constrained position, said outer barrier exhibiting the characteristic of dissolving when exposed to bodily fluids to thereby release said thrombus inducing member to permit said thrombus inducing member to return to the first unconstrained position to thereby react with bodily fluids in order to cause tissue ingrowth.
7. A vascular occlusive device as defined in Claim 6, wherein the support member is a vascular occlusive embolic coil.
8. A vascular occlusive device as defined in Claim 7, wherein the support member takes the form of a helically wound metallic coil.
9. A vascular occlusive device as defined in Claim 6, wherein the outer burner takes the form of a coating applied to the thrombus inducing member.
10. A vascular occlusive device as defined in Claim 6, wherein said thrombus inducing member comprises fibers.
11. A vascular occlusive device as defined in Claim 6, wherein said thrombus inducing member comprises nylon fibers.
12. A vascular occlusive device as defined in Claim 10, wherein said thrombus inducing member comprises bioabsorbable fibers.
13. A vascular occlusive device comprising:
a support member;
a thrombus inducing member disposed on said support member and having a first unconstrained position and a second constrained position; and, an outer barrier disposed on said thrombus inducing member for normally constraining said thrombus inducing member in the second constrained position, said outer barrier exhibiting the characteristic of being substantially inert to bodily fluid but dissolving when exposed to an external agent to thereby release and uncover the thrombus inducing member.
14. A vascular occlusive device as defined in Claim 13, wherein the support member is a vascular occlusive embolic coil.
15. A vascular occlusive device as defined in Claim 14, wherein the support member takes the form of a helically wound metallic coil.
16. A vascular occlusive device as defined in Claim 13, wherein the outer barrier takes the form of a coating applied to the thrombus inducing member.
17. A vascular occlusive device as defined in Claim 13, wherein said thrombus inducing member comprises nylon fibers.
18. A vascular occlusive device as defined in Claim 16, wherein said thrombus inducing member comprises nylon fibers.
19. A vascular occlusive device as defined in Claim 13, wherein said outer barrier is comprised of ethylene alcohol.
CA2503938A 2004-04-08 2005-04-08 Activatable bioactive vascular occlusive device Active CA2503938C (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US10/820,967 US7247159B2 (en) 2004-04-08 2004-04-08 Activatable bioactive vascular occlusive device
US10/820,967 2004-04-08

Publications (2)

Publication Number Publication Date
CA2503938A1 CA2503938A1 (en) 2005-10-08
CA2503938C true CA2503938C (en) 2012-09-25

Family

ID=34912722

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2503938A Active CA2503938C (en) 2004-04-08 2005-04-08 Activatable bioactive vascular occlusive device

Country Status (5)

Country Link
US (2) US7247159B2 (en)
EP (1) EP1584298B1 (en)
JP (1) JP4828150B2 (en)
CA (1) CA2503938C (en)
DE (1) DE602005007090D1 (en)

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Also Published As

Publication number Publication date
US20050228436A1 (en) 2005-10-13
CA2503938A1 (en) 2005-10-08
JP4828150B2 (en) 2011-11-30
JP2005296657A (en) 2005-10-27
DE602005007090D1 (en) 2008-07-10
US7244261B2 (en) 2007-07-17
US7247159B2 (en) 2007-07-24
US20050228435A1 (en) 2005-10-13
EP1584298A1 (en) 2005-10-12
EP1584298B1 (en) 2008-05-28

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