CA2501743A1 - Gas driven gene delivery instrument - Google Patents

Gas driven gene delivery instrument Download PDF

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Publication number
CA2501743A1
CA2501743A1 CA002501743A CA2501743A CA2501743A1 CA 2501743 A1 CA2501743 A1 CA 2501743A1 CA 002501743 A CA002501743 A CA 002501743A CA 2501743 A CA2501743 A CA 2501743A CA 2501743 A1 CA2501743 A1 CA 2501743A1
Authority
CA
Canada
Prior art keywords
cartridge
gene delivery
delivery instrument
particles
tubing
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA002501743A
Other languages
French (fr)
Other versions
CA2501743C (en
Inventor
Dennis E. Mccabe
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Powderject Vaccines Inc
Original Assignee
Powderject Vaccines, Inc.
Dennis E. Mccabe
Agracetus, Inc.
Auragen, Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Powderject Vaccines, Inc., Dennis E. Mccabe, Agracetus, Inc., Auragen, Inc. filed Critical Powderject Vaccines, Inc.
Publication of CA2501743A1 publication Critical patent/CA2501743A1/en
Application granted granted Critical
Publication of CA2501743C publication Critical patent/CA2501743C/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/30—Syringes for injection by jet action, without needle, e.g. for use with replaceable ampoules or carpules
    • A61M5/3015—Syringes for injection by jet action, without needle, e.g. for use with replaceable ampoules or carpules for injecting a dose of particles in form of powdered drug, e.g. mounted on a rupturable membrane and accelerated by a gaseous shock wave or supersonic gas flow
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M35/00—Means for application of stress for stimulating the growth of microorganisms or the generation of fermentation or metabolic products; Means for electroporation or cell fusion
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/002—Packages specially adapted therefor, e.g. for syringes or needles, kits for diabetics
    • A61M2005/005—Magazines with multiple ampoules directly inserted into an injection or infusion device, e.g. revolver-like magazines containing ampoules with or without needles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/20—Automatic syringes, e.g. with automatically actuated piston rod, with automatic needle injection, filling automatically
    • A61M5/2053—Media being expelled from injector by pressurised fluid or vacuum

Abstract

A cartridge for use in a compressed gas-driven gene delivery instrument comprises a body with an arcuate linear passage formed on the interior thereof and a deposit of carrier particles coated with genetic material deposited in the passage in the cartridge so that the particles can be dislodged by an expanding gas stream passing through the passage, the cartridge being manually manipulable by a user without the user having to touch the carrier particles deposited on the cartridge. The cartridge may be employed in combination with a cartridge holder in the gene delivery instrument. A method of making the cartridge comprises suspending particles coated with genetic material in a suspension liquid, introducing the suspension of particles into a length of tubing, and removing the suspension liquid from the tubing to leave the particles deposited in the tubing.
CA002501743A 1994-01-21 1995-01-20 Gas driven gene delivery instrument Expired - Lifetime CA2501743C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US18481294A 1994-01-21 1994-01-21
US184,812 1994-01-21
CA002158733A CA2158733C (en) 1994-01-21 1995-01-20 Gas driven gene delivery instrument

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
CA002158733A Division CA2158733C (en) 1994-01-21 1995-01-20 Gas driven gene delivery instrument

Publications (2)

Publication Number Publication Date
CA2501743A1 true CA2501743A1 (en) 1995-07-27
CA2501743C CA2501743C (en) 2008-11-18

Family

ID=22678443

Family Applications (2)

Application Number Title Priority Date Filing Date
CA002501743A Expired - Lifetime CA2501743C (en) 1994-01-21 1995-01-20 Gas driven gene delivery instrument
CA002158733A Expired - Lifetime CA2158733C (en) 1994-01-21 1995-01-20 Gas driven gene delivery instrument

Family Applications After (1)

Application Number Title Priority Date Filing Date
CA002158733A Expired - Lifetime CA2158733C (en) 1994-01-21 1995-01-20 Gas driven gene delivery instrument

Country Status (16)

Country Link
US (2) US5584807A (en)
EP (3) EP1293559B1 (en)
JP (1) JP3221683B2 (en)
CN (1) CN1112943C (en)
AT (2) ATE300609T1 (en)
AU (1) AU674815B2 (en)
BR (1) BR9505691A (en)
CA (2) CA2501743C (en)
DE (2) DE69534348T2 (en)
DK (2) DK1293559T3 (en)
ES (2) ES2247248T3 (en)
HK (1) HK1013804A1 (en)
NZ (1) NZ279995A (en)
PT (1) PT690732E (en)
RU (1) RU2134295C1 (en)
WO (1) WO1995019799A1 (en)

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