CA2499111A1 - Collagen-based materials and methods for augmenting intervertebral discs - Google Patents
Collagen-based materials and methods for augmenting intervertebral discs Download PDFInfo
- Publication number
- CA2499111A1 CA2499111A1 CA002499111A CA2499111A CA2499111A1 CA 2499111 A1 CA2499111 A1 CA 2499111A1 CA 002499111 A CA002499111 A CA 002499111A CA 2499111 A CA2499111 A CA 2499111A CA 2499111 A1 CA2499111 A1 CA 2499111A1
- Authority
- CA
- Canada
- Prior art keywords
- collagen
- disc
- based material
- augmented
- additionally includes
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
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- A61L2430/38—Materials or treatment for tissue regeneration for reconstruction of the spine, vertebrae or intervertebral discs
Abstract
A method of augmenting an intervertebral disc by injecting particles of collagen-based material into the disc. The particles may be dehydrated before implantation, and rehydrated after implantation, or they may be implanted in a "wet" state - such as a slurry or gel. Radiocontrast materials may be included to enhance imaging of the injected material. Other additives may include analgesics, antibiotics, proteoglycans, growth factors, and/or other cells effective to promote healing and/or proper disc function.
Description
COLLAGEN-BASED MATERIALS AND METHODS
FOR AUGMENTING INTERVERTEBRAL DISCS
FIELD OF THE INVENTION
The present invention relates generally to materials and methods for augmenting intervertebral discs, and more particularly to materials and methods for augmenting intervertebral discs with collagen-based materials.
BACKGROUND OF THE INVENTION
A healthy intervertebral disc facilitates motion between pairs of vertebrae while absorbing and distributing shocks. The disc is composed of two parts: a soft central core (the nucleus pulposus) that bears the majority of the load, and a tough outer ring (the I S annulus fibrosis) that holds and stabilizes the core material.
As the natural aging process progresses, the disc may dehydrate and degenerate, adversely affecting its ability to adequately cushion and support the vertebral bodies. This natural desiccation, which in its more advanced state is often referred to as "black disc"
because of the disc's dehydrated appearance on Magnetic Resonance Imaging [MRI], can cause discomfort to the patient as the vertebrae to come closer together -compressing the spinal nerves and causing pain.
Techniques fox addressing degenerative disc disease have heretofore relied primarily on disc replacement methods. In cases in which a dehydrated and/or degenerating disc was augmented before disc replacement was required, the augmentation materials have primarily been synthetic devices that expand, are inflated, or deploy expanding elements when implanted into the disc.
A need therefore exists for materials and methods effective for augmenting intervertebral discs with natural materials. The present invention addresses that need.
SUMMARY OF THE INVENTION
Briefly describing one aspect of the present invention, there is provided a method of augmenting an intexvertebral disc by injecting particles of collagen-based material into the disc. The particles may be implanted in a dehydrated form, and rehydxated after implantation, or they may be implanted in a hydrated form, such as a slurry or gel. Cross-linking agents such as glutaraldehyde may be included in the injected material to promote collagen crosslinlcing. In addition, radio-contrast materials may be included to enhance imaging of the injected material. Similarly, performance-enhancing additives such as ~ analgesics and/or antibiotics may be included to provide additional therapeutic benefits.
Objects and advantages of the claimed invention will be apparent from the following description.
BRIEF DESCRIPTION OF THE DRAWINGS
FIGS. lA-1D show a procedure for injecting a collagen-based material into an intervertebral disc, according to one preferred embodiment of the present invention.
FIGS. 2A-2F show a procedure for injecting a collagen-based material into an intervertebral disc, according to another preferred embodiment of the present invention.
DESCRIPTION OF THE PREFERRED EMBODIMENTS
For the purposes of promoting an understanding of the principles of the invention, reference will now be made to certain preferred embodiments and specific language will be used to describe the same. It will nevertheless be understood that no limitation of the scope of the invention is thereby intended, such alterations and further modifications in the preferred embodiments being contemplated as would normally occur to one skilled in the art to which the invention relates.
As indicated above, one aspect of the present invention relates to materials and methods for using collagen-based material to augment an intervertebral disc.
In the most preferred embodiments the collagen-based material is injected into a disc nucleus that is contained in a substantially sound annulus. In other embodiments the collagen-based material is injected into a disc nucleus that is contained in a damaged or defective annulus.
The collagen-based material is prefexably derived from natural, collagen-rich tissue, such as intervertebral disc, fascia, ligament, tendon, demineralized bone matrix, etc.
The material may be autogenic, allogenic, or xenogenic, or it may be of human-recombinant origin. In alternative embodiments the collagen-based material may be a synthetic, collagen-based material. Examples of preferred collagen-rich tissues include disc annulus, fascia lata, planar fascia, anterior or posterior cruciate ligaments, patella tendon, hamstring tendons, quadriceps tendons, Achilles tendons, skins, and other connective tissues.
The collagen-based material may be provided in any form appropriate for introduction into a disc space. For example, the material may be a solid, porous, woven, or non-woven material. The material may be provided as particles or small pieces, or as a fibrous material.
Tn some embodiments the material is provided in a dehydrated state, and is "rehydrated" after implantation in the disc. In other embodiments the material is implanted "wet." When the material is "wet," it may be that way because it has never been dehydrated, or it may have been dehydrated and reconstituted. When reconstituted, the material may be reconstituted with saline or another aqueous medium, or it may be reconstituted with a non-aqueous medium such as ethylene glycol or another alcohol.
Moreover, when provided in a "wet" state, the material may be provided as a gel, solution, suspension, dispersion, emulsion, paste, etc.
In the most preferred embodiments the material is a particulate and/or fibrous material suitable for injection through a hypodermic needle into a disc.
In the most preferred embodiments the collagen material is provided as particles ranging between .OSmm and Smm in size. When materials such as fascia lata or disc annulus particles are used the particles preferably range in size from .lmm to Smrn. When materials such as demineralized bone matrix are used the particles preferably range in size from .OSmm to 3mm. When small plugs of material are used the plugs preferably range in size from .Smm to Smm. In some embodiments larger sized pieces, such as pieces up to ZOmm in size, may be used.
The materials may be processed or fabricated using more than one type of tissue.
For example, mixtures of fascia lata and demineralized bone matrix may be preferred in appropriate cases, as may mixtures of DBM and annulus fibrosis material.
FOR AUGMENTING INTERVERTEBRAL DISCS
FIELD OF THE INVENTION
The present invention relates generally to materials and methods for augmenting intervertebral discs, and more particularly to materials and methods for augmenting intervertebral discs with collagen-based materials.
BACKGROUND OF THE INVENTION
A healthy intervertebral disc facilitates motion between pairs of vertebrae while absorbing and distributing shocks. The disc is composed of two parts: a soft central core (the nucleus pulposus) that bears the majority of the load, and a tough outer ring (the I S annulus fibrosis) that holds and stabilizes the core material.
As the natural aging process progresses, the disc may dehydrate and degenerate, adversely affecting its ability to adequately cushion and support the vertebral bodies. This natural desiccation, which in its more advanced state is often referred to as "black disc"
because of the disc's dehydrated appearance on Magnetic Resonance Imaging [MRI], can cause discomfort to the patient as the vertebrae to come closer together -compressing the spinal nerves and causing pain.
Techniques fox addressing degenerative disc disease have heretofore relied primarily on disc replacement methods. In cases in which a dehydrated and/or degenerating disc was augmented before disc replacement was required, the augmentation materials have primarily been synthetic devices that expand, are inflated, or deploy expanding elements when implanted into the disc.
A need therefore exists for materials and methods effective for augmenting intervertebral discs with natural materials. The present invention addresses that need.
SUMMARY OF THE INVENTION
Briefly describing one aspect of the present invention, there is provided a method of augmenting an intexvertebral disc by injecting particles of collagen-based material into the disc. The particles may be implanted in a dehydrated form, and rehydxated after implantation, or they may be implanted in a hydrated form, such as a slurry or gel. Cross-linking agents such as glutaraldehyde may be included in the injected material to promote collagen crosslinlcing. In addition, radio-contrast materials may be included to enhance imaging of the injected material. Similarly, performance-enhancing additives such as ~ analgesics and/or antibiotics may be included to provide additional therapeutic benefits.
Objects and advantages of the claimed invention will be apparent from the following description.
BRIEF DESCRIPTION OF THE DRAWINGS
FIGS. lA-1D show a procedure for injecting a collagen-based material into an intervertebral disc, according to one preferred embodiment of the present invention.
FIGS. 2A-2F show a procedure for injecting a collagen-based material into an intervertebral disc, according to another preferred embodiment of the present invention.
DESCRIPTION OF THE PREFERRED EMBODIMENTS
For the purposes of promoting an understanding of the principles of the invention, reference will now be made to certain preferred embodiments and specific language will be used to describe the same. It will nevertheless be understood that no limitation of the scope of the invention is thereby intended, such alterations and further modifications in the preferred embodiments being contemplated as would normally occur to one skilled in the art to which the invention relates.
As indicated above, one aspect of the present invention relates to materials and methods for using collagen-based material to augment an intervertebral disc.
In the most preferred embodiments the collagen-based material is injected into a disc nucleus that is contained in a substantially sound annulus. In other embodiments the collagen-based material is injected into a disc nucleus that is contained in a damaged or defective annulus.
The collagen-based material is prefexably derived from natural, collagen-rich tissue, such as intervertebral disc, fascia, ligament, tendon, demineralized bone matrix, etc.
The material may be autogenic, allogenic, or xenogenic, or it may be of human-recombinant origin. In alternative embodiments the collagen-based material may be a synthetic, collagen-based material. Examples of preferred collagen-rich tissues include disc annulus, fascia lata, planar fascia, anterior or posterior cruciate ligaments, patella tendon, hamstring tendons, quadriceps tendons, Achilles tendons, skins, and other connective tissues.
The collagen-based material may be provided in any form appropriate for introduction into a disc space. For example, the material may be a solid, porous, woven, or non-woven material. The material may be provided as particles or small pieces, or as a fibrous material.
Tn some embodiments the material is provided in a dehydrated state, and is "rehydrated" after implantation in the disc. In other embodiments the material is implanted "wet." When the material is "wet," it may be that way because it has never been dehydrated, or it may have been dehydrated and reconstituted. When reconstituted, the material may be reconstituted with saline or another aqueous medium, or it may be reconstituted with a non-aqueous medium such as ethylene glycol or another alcohol.
Moreover, when provided in a "wet" state, the material may be provided as a gel, solution, suspension, dispersion, emulsion, paste, etc.
In the most preferred embodiments the material is a particulate and/or fibrous material suitable for injection through a hypodermic needle into a disc.
In the most preferred embodiments the collagen material is provided as particles ranging between .OSmm and Smm in size. When materials such as fascia lata or disc annulus particles are used the particles preferably range in size from .lmm to Smrn. When materials such as demineralized bone matrix are used the particles preferably range in size from .OSmm to 3mm. When small plugs of material are used the plugs preferably range in size from .Smm to Smm. In some embodiments larger sized pieces, such as pieces up to ZOmm in size, may be used.
The materials may be processed or fabricated using more than one type of tissue.
For example, mixtures of fascia lata and demineralized bone matrix may be preferred in appropriate cases, as may mixtures of DBM and annulus fibrosis material.
Cross-linking agents may be added to the formulation to promote cross-linking of the collagen material. For example, glutaraldehyde ox other protein cross-linking agents may be included in the formulation. The cross-linking agents may promote covalent ox non-covalent crosslinks between collagen molecules. Similarly, agents to inhibit protein denaturization may also be included. Crosslinking agents that would be appropriate for use in the claimed invention are known to persons skilled in the art, and may be selected without undue expeximentation.
When the material is to be used as a slurry or gel, additives to promote slurry or gel formation may also be included. These additives may promote protein folding, water I O binding, protein-protein interactions, and water immobilization.
In addition, a radiocontrast media, such as barium sulfate, or a radiocontrast dye, such as HYPAQUE~, may be included to aid the surgeon in tracking the movement and/or location of the injected material. Radiocontrast materials appropriate for use in discography are known to persons skilled in the art, and may be selected for use in the I S present invention without undue experimentation.
Finally, other additives to provide benefits to the injected collagen-based material may also be included. Such additives include anesthetics, to reduce pain caused by the procedure, and antibiotics, to minimize the potential for bacterial infection.
Proteoglycans may also be included to attract andlor bind water to keep the nucleus 20 hydrated. Similarly, growth factors and/or other cells (e.g., intervertebral disc cells, stem cells, etc.) to promote healing, repair, regeneration and/or restoration of the disc, and/or to facilitate proper disc function, may also be included. Additives appropriate for use in the claimed invention are known to persons skilled in the art, and may be selected without undue experimentation.
25 In some embodiments the collagen material is dehydrated before injection into the disc space, where it is xehydrated by absorbing fluid from the disc space. In other embodiments the collagen material is provided as a gel, slurry, or other hydrated formulation before implantation.
The collagen-based material is "surgically added" to the disc space. That is, the 30 material is added by the intervention of medical personnel, as distinguished from being "added" by the body's natural growth or regeneration processes. The surgical procedure preferably includes injection through a hypodermic needle, although other surgical methods of introducing the collagen-based material into the disc may be used.
For example, the material may be introduced into a disc by extrusion through a dilated annular opening, infusion through a catheter, insertion through an opening created by trauma or 5 surgical incision, or by other means of invasive or minimally invasive deposition of the materials into the disc space.
Referring now to the drawings, FIGS. lA-1D show one method of injecting a collagen-based material into a disc. In FIG. lA, dehydrated particulate fascia lata or annulus fibrosis material 11 is provided in a syringe 12 (in a sterile package). The material is rehydrated and/or dispersed in a suspension medium as shown in FIG. 1B, to provide a wet dispersion 13 of collagen-based material. A hypodermic needle 14 is attached to syringe 12, and the syringe is inserted into a nucleus pulposus 15 contained within a disc annulus 16 (FIG. 1C). The needle/syringe may be moved around within the disc space, sweeping from side to side and back and forth, to ensure uniform distribution of the collagen-based material 13 within the disc space, as shown in FIG. 1D.
It is preferred, however, that the tip of the needle be maintained near the center of the disc to ensure deposition of the material within the nuclear disc space, and to minimize potential leakage.
Alternatively, small collagen plugs 21 may be inserted into the disc space as shown in FIGS. 2A-2F. The collagen plugs 21 may be compressed before or by insertion into a small diameter tube 22, and are provided in a delivery cannula 23 (FIGS. 2A-2C). The delivery cannula 23 is attached to a dilator 24.
The compressed plugs are inserted into a disc nucleus 25 having a substantially intact annulus 26 by penetrating the annulus with a guide needle 27 (FIG. 2D).
Dilator 24, preferably with delivery cannula 23 already attached, is inserted through the annulus over guide needle 27 (FIG. 2E). The collagen plugs 21 are then ready for injection (or extrusion) into the disc space.
The collagen plugs axe deposited into the disc space. As with the wet particulate/fibrous material, the caxmula may be moved up and back, and/or side to side, to ensure even distribution of the plugs (FIG. 2F) a plunger 28 may be used to push the plugs from the cannula.
When the material is to be used as a slurry or gel, additives to promote slurry or gel formation may also be included. These additives may promote protein folding, water I O binding, protein-protein interactions, and water immobilization.
In addition, a radiocontrast media, such as barium sulfate, or a radiocontrast dye, such as HYPAQUE~, may be included to aid the surgeon in tracking the movement and/or location of the injected material. Radiocontrast materials appropriate for use in discography are known to persons skilled in the art, and may be selected for use in the I S present invention without undue experimentation.
Finally, other additives to provide benefits to the injected collagen-based material may also be included. Such additives include anesthetics, to reduce pain caused by the procedure, and antibiotics, to minimize the potential for bacterial infection.
Proteoglycans may also be included to attract andlor bind water to keep the nucleus 20 hydrated. Similarly, growth factors and/or other cells (e.g., intervertebral disc cells, stem cells, etc.) to promote healing, repair, regeneration and/or restoration of the disc, and/or to facilitate proper disc function, may also be included. Additives appropriate for use in the claimed invention are known to persons skilled in the art, and may be selected without undue experimentation.
25 In some embodiments the collagen material is dehydrated before injection into the disc space, where it is xehydrated by absorbing fluid from the disc space. In other embodiments the collagen material is provided as a gel, slurry, or other hydrated formulation before implantation.
The collagen-based material is "surgically added" to the disc space. That is, the 30 material is added by the intervention of medical personnel, as distinguished from being "added" by the body's natural growth or regeneration processes. The surgical procedure preferably includes injection through a hypodermic needle, although other surgical methods of introducing the collagen-based material into the disc may be used.
For example, the material may be introduced into a disc by extrusion through a dilated annular opening, infusion through a catheter, insertion through an opening created by trauma or 5 surgical incision, or by other means of invasive or minimally invasive deposition of the materials into the disc space.
Referring now to the drawings, FIGS. lA-1D show one method of injecting a collagen-based material into a disc. In FIG. lA, dehydrated particulate fascia lata or annulus fibrosis material 11 is provided in a syringe 12 (in a sterile package). The material is rehydrated and/or dispersed in a suspension medium as shown in FIG. 1B, to provide a wet dispersion 13 of collagen-based material. A hypodermic needle 14 is attached to syringe 12, and the syringe is inserted into a nucleus pulposus 15 contained within a disc annulus 16 (FIG. 1C). The needle/syringe may be moved around within the disc space, sweeping from side to side and back and forth, to ensure uniform distribution of the collagen-based material 13 within the disc space, as shown in FIG. 1D.
It is preferred, however, that the tip of the needle be maintained near the center of the disc to ensure deposition of the material within the nuclear disc space, and to minimize potential leakage.
Alternatively, small collagen plugs 21 may be inserted into the disc space as shown in FIGS. 2A-2F. The collagen plugs 21 may be compressed before or by insertion into a small diameter tube 22, and are provided in a delivery cannula 23 (FIGS. 2A-2C). The delivery cannula 23 is attached to a dilator 24.
The compressed plugs are inserted into a disc nucleus 25 having a substantially intact annulus 26 by penetrating the annulus with a guide needle 27 (FIG. 2D).
Dilator 24, preferably with delivery cannula 23 already attached, is inserted through the annulus over guide needle 27 (FIG. 2E). The collagen plugs 21 are then ready for injection (or extrusion) into the disc space.
The collagen plugs axe deposited into the disc space. As with the wet particulate/fibrous material, the caxmula may be moved up and back, and/or side to side, to ensure even distribution of the plugs (FIG. 2F) a plunger 28 may be used to push the plugs from the cannula.
The plugs expand upon exiting the dilator, and may further expand as they xehydrate in the disc space.
As to the benefits of the inventive materials and methods, augmentation of the intervertebral disc may restore or improve the natural condition and/ox performance of the disc. In addition, augmentation may retard or reverse the progressive degeneration of a dehydrated disc.
Reference will now be made to speciEc examples using the processes described above. It is to be understood that the examples are provided to more completely describe preferred embodiments, and that no limitation to the scope of the invention is intended thereby.
Hydrated Particulate Fascia Lata A suspension of particulate or fibrous (autologous or allogenic) fascia late is prepared in a biocompatible medium such as saline or ethylene glycol. The particle size ranges from 0.1 mm to 5 mm, with most particles being between 0.25 and 2 mrn.
The suspension is injected directly into the nuclear disc space through an intact annulus using a hypodermic needle, and is contained within the disc space following injection. The medium subsequently diffuses out of the disc space and leaves the fascia late material behind.
Inspection of the disc reveals that an appropriate level of augmentation may be obtained with a single injection of material. Alternatively, several smaller doses/injections may be used to achieve comparable results.
Hydrated Particulate Fascia Lata With Crosslinkin~ Agent A suspension of particulate or fibxous (autologous or allogenic) fascia late is prepared in a biocompatible medium such as saline or ethylene glycol. The particle size ranges from 0.1 mm to 5 mm, with most particles being between 0.25 mm and 2 mm. A
glutaraldehyde crosslinking agent is added to promote collagen crosslinking.
As to the benefits of the inventive materials and methods, augmentation of the intervertebral disc may restore or improve the natural condition and/ox performance of the disc. In addition, augmentation may retard or reverse the progressive degeneration of a dehydrated disc.
Reference will now be made to speciEc examples using the processes described above. It is to be understood that the examples are provided to more completely describe preferred embodiments, and that no limitation to the scope of the invention is intended thereby.
Hydrated Particulate Fascia Lata A suspension of particulate or fibrous (autologous or allogenic) fascia late is prepared in a biocompatible medium such as saline or ethylene glycol. The particle size ranges from 0.1 mm to 5 mm, with most particles being between 0.25 and 2 mrn.
The suspension is injected directly into the nuclear disc space through an intact annulus using a hypodermic needle, and is contained within the disc space following injection. The medium subsequently diffuses out of the disc space and leaves the fascia late material behind.
Inspection of the disc reveals that an appropriate level of augmentation may be obtained with a single injection of material. Alternatively, several smaller doses/injections may be used to achieve comparable results.
Hydrated Particulate Fascia Lata With Crosslinkin~ Agent A suspension of particulate or fibxous (autologous or allogenic) fascia late is prepared in a biocompatible medium such as saline or ethylene glycol. The particle size ranges from 0.1 mm to 5 mm, with most particles being between 0.25 mm and 2 mm. A
glutaraldehyde crosslinking agent is added to promote collagen crosslinking.
The suspension is injected directly into the nuclear disc space through an intact annulus using a hypodermic needle, and is contained within the disc space following injection. The medium subsequently diffuses out of the disc space and leaves the fascia lata material behind.
Inspection of the disc reveals that an appropriate level of augmentation may be obtained through either a single injection of material, or by multiple injections.
Dehydrated Particulate Fascia Lata Dehydrated fascia lata material is provided in particulate form. Particle sizes range between 0.05 mm and 3 mm, with most particles being between 0.10 mm and 1 mrn.
The dehydrated material is loaded in a specially designed syringe for delivery of solid materials.
The material is extruded into the nuclear disc space of the treated disc through a small dilated annular opening. The material remains inside the disc space after the needle is removed. It subsequently absorbs moisture or body fluids and swells up in vivo.
Inspection of the disc reveals that an appropriate level of augmentation may be obtained through either a single injection of material, or by multiple injections.
Hydrated Particulate Disc Annulus Material A suspension of particulate or fibrous allogenic annulus fibrosis is prepared in a biocompatible medium such as saline or ethylene glycol. The particle size ranges from 0.1 mm to 5 mm, with most particles being between 0.25 and 2 mm.
The suspension is injected directly into the nuclear disc space through an intact annulus using a hypodermic needle. The suspension is contained within the disc space following injection. The medium subsequently diffuses out of the disc space and leaves the annulus fibrosis material behind.
Inspection of the disc reveals that an appropriate level of augmentation may be obtained through either a single injection of material, or by multiple injections.
Hydrated Particulate Disc Annulus Material With Crosslinkin Aft A suspension of particulate or fibrous allogenic annulus fibrosis is prepared in a biocompatible medium such as saline or ethylene glycol. The particle size ranges from 0.1 mm to 5 mm, with most particles being between 0.25 and 2 mm. A glutaraldehyde crosslinking agent is added to promote collagen crosslinking.
The suspension is injected directly into the nuclear disc space through an intact annulus using a hypodermic needle. 'The suspension is contained within the disc space following injection. The medium subsequently diffuses out of the disc space and leaves the annulus fibrosis material behind.
Inspection of the disc reveals that an appropriate level of augmentation may be obtained through either a single injection of material, or by multiple injections.
Dehydrated Annulus Fibrosis Dehydrated annulus fibrosis is provided in granule, particulate and powder form, for example 3A-3C respectively. Particle sizes range between 0.05 mm and 3 mm, with most particles being between 0.10 mm and 1 mm. The dehydrated material is loaded in a specially designed syringe for delivery of solid materials.
The material is extruded into the nuclear disc space of the treated disc through a small dilated annular opening. The material remains inside the disc space after the needle is removed. It subsequently absorbs moisture ox body fluids and swells up in vivo.
Inspection of the disc reveals that an appropriate level of augmentation may be obtained through either a single injection of material, or by multiple injections.
Demineralized Bona Matrix (DBM) Gel Demineralized bone matrix (DBM) gel is provided with and without glutaraldehyde as a cross-linker additive (examples 4A and 4B, respectively).
In both cases the material is warmed up to an appropriate temperature for melting or thinning out the gel, and is injected directly into the nuclear disc space through an intact annulus using a hypodermic needle. The DBM gel becomes solidified in the disc space after injection.
0 Inspection of the disc reveals that an appropriate level of augmentation may be obtained through either a single injection of material, or by multiple injections.
Dehydrated Deminexalized Bone Matrix ~DBM) Dehydrated DBM is provided in granule, particulate and powder form. Particle sizes range between 0.05 mm and 3 mm, with most panicles being between 0.10 mm and 1 mm. The dehydrated material is loaded in a specially designed syringe for delivery of solid materials.
The material is extruded into the nuclear disc space of the treated disc through a small dilated annular opening. The material remains inside the disc space after the needle is removed. It subsequently absorbs moisture or body fluids and swells up in vivo.
Inspection of the disc reveals that an appropriate level of augmentation may be obtained through either a single injection of material, or by multiple injections.
EXAMPLE SA-SD
Mixtures of annulus fibrosis and demineralized bone matrix Mixtures of particulate and fibrous allogenic annulus fibrosis and demineralized bone matrix (DBM) gel, with and without additives and/or cross-linkers, are provided.
The materials are warmed up to an appropriate temperature for melting or thinning out the gel mixture, and are injected directly into the nuclear disc space through an intact annulus using a hypodermic needle. The gel mixture becomes solidified in the disc space after inj ection.
Inspection of the disc reveals that an appropriate level of augmentation may be obtained through either a single injection of material, or by multiple injections.
Elongated cylindrical plugs (0.5 mm to S mm in diameter, preferably 1 mm to 2 mm) of solid, porous, or fibrous collagen are provided in a dehydrated state.
The plugs are compressed in the radial direction and are inserted into delivery cannula for delivery into disc space.
A guide wire or needle is used to penetrate the disc space through an intact annulus. A dilator is subsequently inserted into the disc space over the guide wire/needle, 1 S and the guide wire/needle is removed. The delivery cannula containing a collagen plug is attached to the dilator prior to extrusion of the plug into the disc space. As the plugs absorb moisture after entering the disc space, they become more compliant, flexible and expanded.
The level of disc augmentation achieved depends on the number of plugs inserted, 20 and/or on the total plug volume deposited in the disc space.
Cylindrical plugs or rolls (2 mm - 20 rnm in diameter, preferably I O -1 S mm) of 2S solid, porous, or fibrous collagen are provided in a dehydrated state. The dehydrated plugs are typically more rigid than those in hydrated state, and thus, can be easily inserted into the disc space through an annular opening created by trauma or surgical incision.
Nucleotomy is necessary before the plug can be inserted. As the plugs absorb moisture after entering the disc space, they become more compliant, flexible and 30 expanded.
The level of disc augmentation/replacement achieved depends on the size and number of plugs inserted into the disc space.
S
Particulate fascia used for cosmetic procedure (FASCIAN~) was modified to include a radiocontrast media. A small quantity of barium sulfate powder was blended with 80 mg of >O.S mm Gastrocemius Fascia for visualization under fluoroscopic imaging. About 1-l.S cc of water was added to the blend in the syringe for hydration.
After hydration for S-I O minutes, the material (Fascian/Barium Sulfate/Water or F.B.W.) was injected into the nuclear disc space of a harvested porcine intervertebxal disc.
X-ray images of the disc were obtained before and after injection.
A small increase in disc height was noticed after injection. Also, manual compression indicated that the disc was stiffer after injection. The injected disc was also tested under compression up to SOOON. There was no gross leakage observed during the compression test. Only a slight oozing of a small amount of injected material was observed at the injection site, but it stopped quickly.
The disc was cut in the horizontal plane to confirm the location of the injected material. F.B.W. was found contained within the disc annulus and mixed in with nucleus pulposus.
Particulate fascia used for cosmetic procedures (FASCIAN~) was modified before experimentation to include a xadiocontrast material. A small quantity of radio-contrast dye or barium sulfate powder was blended with about 200 mg of 0.25 - I .0 mm Gastrocemius Fascia for visualization under fluoroscopic imaging. About 1.S-3 cc of saline was added to the blend in the syringe for hydration.
After hydration for about 30 minutes, the material (FascianlDye or Barium Sulfate/Water) was injected into the nuclear disc space of cadaveric intervertebral discs (L2-3 and L3-4). X-ray images of the discs were obtained before and after injection. A
small increase in disc height was noticed radiographically after injection.
There was no gross leakage observed at the injection site. In the case of L3-4 injection, the needle tip was maintained approximately at the center of the disc, which resulted in material deposition mainly within the nucleus pulposus.
Particulate fascia (FASCIAN~) having particle sizes of 0.25mm and O.Smm was purchased from Fascia BioSystems. Collagen solutions were prepared, with each solution I O consisting of approximately 80 mg of particulate fascia, 0.75 ml of saline, and 0.25 ml HYPAQUE~ radiocontrast solution.
Thoracic and lumbar discs in two pigs were subjected to stabbing injury. The injured discs were then injected with 1-2 ml of collagen solution at 4 weeks after injury.
The injections were performed using a 3 ml syringe, a 20 gauge hypodermic needle and a I S graft placement device. Confirming X-ray was taken using C-arm fluoroscopy.
The injured discs appeared to have somewhat reduced heights at four weeks after injury. Of approximately 12 injected discs, there was only one leakage observed. The amount of leakage was visually estimated to be less than 20% of the total volume injected.
The low incidence of leakage indicates that the annulus is capable of self sealing when a 20 small gauge needle is used for injection.
The disc height increased upon collagen injection depending on the injected volume. In particular, an approximately 46% increase in disc height was achieved with 2 ml injection. In some cases the disc height gain was reduced after injection as radio-contrast dye and water molecules diffused out of the disc under infra-distal pressure.
While the invention has been illustrated and described in detail in the drawings and foregoing description, the same is to be considered as illustrative and not restrictive in character, it being understood that only the preferred embodiment has been shown and described arid that all changes and modifications that come within the spirit of the invention are desired to be protected.
Inspection of the disc reveals that an appropriate level of augmentation may be obtained through either a single injection of material, or by multiple injections.
Dehydrated Particulate Fascia Lata Dehydrated fascia lata material is provided in particulate form. Particle sizes range between 0.05 mm and 3 mm, with most particles being between 0.10 mm and 1 mrn.
The dehydrated material is loaded in a specially designed syringe for delivery of solid materials.
The material is extruded into the nuclear disc space of the treated disc through a small dilated annular opening. The material remains inside the disc space after the needle is removed. It subsequently absorbs moisture or body fluids and swells up in vivo.
Inspection of the disc reveals that an appropriate level of augmentation may be obtained through either a single injection of material, or by multiple injections.
Hydrated Particulate Disc Annulus Material A suspension of particulate or fibrous allogenic annulus fibrosis is prepared in a biocompatible medium such as saline or ethylene glycol. The particle size ranges from 0.1 mm to 5 mm, with most particles being between 0.25 and 2 mm.
The suspension is injected directly into the nuclear disc space through an intact annulus using a hypodermic needle. The suspension is contained within the disc space following injection. The medium subsequently diffuses out of the disc space and leaves the annulus fibrosis material behind.
Inspection of the disc reveals that an appropriate level of augmentation may be obtained through either a single injection of material, or by multiple injections.
Hydrated Particulate Disc Annulus Material With Crosslinkin Aft A suspension of particulate or fibrous allogenic annulus fibrosis is prepared in a biocompatible medium such as saline or ethylene glycol. The particle size ranges from 0.1 mm to 5 mm, with most particles being between 0.25 and 2 mm. A glutaraldehyde crosslinking agent is added to promote collagen crosslinking.
The suspension is injected directly into the nuclear disc space through an intact annulus using a hypodermic needle. 'The suspension is contained within the disc space following injection. The medium subsequently diffuses out of the disc space and leaves the annulus fibrosis material behind.
Inspection of the disc reveals that an appropriate level of augmentation may be obtained through either a single injection of material, or by multiple injections.
Dehydrated Annulus Fibrosis Dehydrated annulus fibrosis is provided in granule, particulate and powder form, for example 3A-3C respectively. Particle sizes range between 0.05 mm and 3 mm, with most particles being between 0.10 mm and 1 mm. The dehydrated material is loaded in a specially designed syringe for delivery of solid materials.
The material is extruded into the nuclear disc space of the treated disc through a small dilated annular opening. The material remains inside the disc space after the needle is removed. It subsequently absorbs moisture ox body fluids and swells up in vivo.
Inspection of the disc reveals that an appropriate level of augmentation may be obtained through either a single injection of material, or by multiple injections.
Demineralized Bona Matrix (DBM) Gel Demineralized bone matrix (DBM) gel is provided with and without glutaraldehyde as a cross-linker additive (examples 4A and 4B, respectively).
In both cases the material is warmed up to an appropriate temperature for melting or thinning out the gel, and is injected directly into the nuclear disc space through an intact annulus using a hypodermic needle. The DBM gel becomes solidified in the disc space after injection.
0 Inspection of the disc reveals that an appropriate level of augmentation may be obtained through either a single injection of material, or by multiple injections.
Dehydrated Deminexalized Bone Matrix ~DBM) Dehydrated DBM is provided in granule, particulate and powder form. Particle sizes range between 0.05 mm and 3 mm, with most panicles being between 0.10 mm and 1 mm. The dehydrated material is loaded in a specially designed syringe for delivery of solid materials.
The material is extruded into the nuclear disc space of the treated disc through a small dilated annular opening. The material remains inside the disc space after the needle is removed. It subsequently absorbs moisture or body fluids and swells up in vivo.
Inspection of the disc reveals that an appropriate level of augmentation may be obtained through either a single injection of material, or by multiple injections.
EXAMPLE SA-SD
Mixtures of annulus fibrosis and demineralized bone matrix Mixtures of particulate and fibrous allogenic annulus fibrosis and demineralized bone matrix (DBM) gel, with and without additives and/or cross-linkers, are provided.
The materials are warmed up to an appropriate temperature for melting or thinning out the gel mixture, and are injected directly into the nuclear disc space through an intact annulus using a hypodermic needle. The gel mixture becomes solidified in the disc space after inj ection.
Inspection of the disc reveals that an appropriate level of augmentation may be obtained through either a single injection of material, or by multiple injections.
Elongated cylindrical plugs (0.5 mm to S mm in diameter, preferably 1 mm to 2 mm) of solid, porous, or fibrous collagen are provided in a dehydrated state.
The plugs are compressed in the radial direction and are inserted into delivery cannula for delivery into disc space.
A guide wire or needle is used to penetrate the disc space through an intact annulus. A dilator is subsequently inserted into the disc space over the guide wire/needle, 1 S and the guide wire/needle is removed. The delivery cannula containing a collagen plug is attached to the dilator prior to extrusion of the plug into the disc space. As the plugs absorb moisture after entering the disc space, they become more compliant, flexible and expanded.
The level of disc augmentation achieved depends on the number of plugs inserted, 20 and/or on the total plug volume deposited in the disc space.
Cylindrical plugs or rolls (2 mm - 20 rnm in diameter, preferably I O -1 S mm) of 2S solid, porous, or fibrous collagen are provided in a dehydrated state. The dehydrated plugs are typically more rigid than those in hydrated state, and thus, can be easily inserted into the disc space through an annular opening created by trauma or surgical incision.
Nucleotomy is necessary before the plug can be inserted. As the plugs absorb moisture after entering the disc space, they become more compliant, flexible and 30 expanded.
The level of disc augmentation/replacement achieved depends on the size and number of plugs inserted into the disc space.
S
Particulate fascia used for cosmetic procedure (FASCIAN~) was modified to include a radiocontrast media. A small quantity of barium sulfate powder was blended with 80 mg of >O.S mm Gastrocemius Fascia for visualization under fluoroscopic imaging. About 1-l.S cc of water was added to the blend in the syringe for hydration.
After hydration for S-I O minutes, the material (Fascian/Barium Sulfate/Water or F.B.W.) was injected into the nuclear disc space of a harvested porcine intervertebxal disc.
X-ray images of the disc were obtained before and after injection.
A small increase in disc height was noticed after injection. Also, manual compression indicated that the disc was stiffer after injection. The injected disc was also tested under compression up to SOOON. There was no gross leakage observed during the compression test. Only a slight oozing of a small amount of injected material was observed at the injection site, but it stopped quickly.
The disc was cut in the horizontal plane to confirm the location of the injected material. F.B.W. was found contained within the disc annulus and mixed in with nucleus pulposus.
Particulate fascia used for cosmetic procedures (FASCIAN~) was modified before experimentation to include a xadiocontrast material. A small quantity of radio-contrast dye or barium sulfate powder was blended with about 200 mg of 0.25 - I .0 mm Gastrocemius Fascia for visualization under fluoroscopic imaging. About 1.S-3 cc of saline was added to the blend in the syringe for hydration.
After hydration for about 30 minutes, the material (FascianlDye or Barium Sulfate/Water) was injected into the nuclear disc space of cadaveric intervertebral discs (L2-3 and L3-4). X-ray images of the discs were obtained before and after injection. A
small increase in disc height was noticed radiographically after injection.
There was no gross leakage observed at the injection site. In the case of L3-4 injection, the needle tip was maintained approximately at the center of the disc, which resulted in material deposition mainly within the nucleus pulposus.
Particulate fascia (FASCIAN~) having particle sizes of 0.25mm and O.Smm was purchased from Fascia BioSystems. Collagen solutions were prepared, with each solution I O consisting of approximately 80 mg of particulate fascia, 0.75 ml of saline, and 0.25 ml HYPAQUE~ radiocontrast solution.
Thoracic and lumbar discs in two pigs were subjected to stabbing injury. The injured discs were then injected with 1-2 ml of collagen solution at 4 weeks after injury.
The injections were performed using a 3 ml syringe, a 20 gauge hypodermic needle and a I S graft placement device. Confirming X-ray was taken using C-arm fluoroscopy.
The injured discs appeared to have somewhat reduced heights at four weeks after injury. Of approximately 12 injected discs, there was only one leakage observed. The amount of leakage was visually estimated to be less than 20% of the total volume injected.
The low incidence of leakage indicates that the annulus is capable of self sealing when a 20 small gauge needle is used for injection.
The disc height increased upon collagen injection depending on the injected volume. In particular, an approximately 46% increase in disc height was achieved with 2 ml injection. In some cases the disc height gain was reduced after injection as radio-contrast dye and water molecules diffused out of the disc under infra-distal pressure.
While the invention has been illustrated and described in detail in the drawings and foregoing description, the same is to be considered as illustrative and not restrictive in character, it being understood that only the preferred embodiment has been shown and described arid that all changes and modifications that come within the spirit of the invention are desired to be protected.
Claims (34)
1. A method of augmenting an intervertebral disc, said method comprising surgically adding to an intervertebral disc a composition comprising particulate collagen-based material.
2. The method of claim 1 wherein said surgically adding step comprises injecting particulate collagen-based material into an intervertebral disc.
3. The method of claim 1 wherein said collagen-based material comprises particles ranging from 0.05mm to 5mm in size.
4. The method of claim 1 wherein said collagen-based material comprises particles ranging from 0.05mm to 3mm in size.
5. The method of claim 1 wherein said collagen-based material comprises particles ranging from 0.05mm to 1mm in size.
6. The method of claim 1 wherein said collagen-based material comprises particles ranging from 0.25mm to 1mm in size.
7. The method of claim 1 wherein said collagen-based material is injected in a dehydrated state.
8. The method of claim 1 wherein said collagen-based material is injected in a non-dehydrated state.
9. The method of claim 8 wherein said collagen-based material is injected as a gel.
10. The method of claim 8 wherein said collagen-based material is injected as a solution or suspension.
11. The method of claim 1 wherein said collagen-based material is provided as a formulation that additionally includes a cross-linking agent to promote crosslinking of collagen molecules.
12. The method of claim 1 wherein said collagen-based material is provided as a formulation that additionally includes a radiocontrast media.
13. The method of claim 1 wherein said collagen-based material is provided as a formulation that additionally includes an analgesic.
14. The method of claim 1 wherein said collagen-based material is provided as a formulation that additionally includes an antibiotic.
15. The method of claim 1 wherein said collagen-based material is provided as a formulation that additionally includes proteoglycans.
16. The method of claim 1 wherein said collagen-based material is provided as a formulation that additionally includes growth factors.
17. The method of claim 1 wherein said collagen-based material is provided as a formulation that additionally includes one or more other types of cells effective to promote healing, repair, regeneration and/or restoration of the disc, and/or to facilitate proper disc function.
18. An intervertebral disc augmented with particulate collagen-based material.
19. The augmented disc of claim 18 wherein said collagen-based material comprises collagen-based material that has been injected into the disc.
20. The augmented disc of claim 18 wherein said collagen-based material comprises particles ranging from 0.05mm to 5mm in size.
21. The augmented disc of claim 18 wherein said collagen-based material comprises particles ranging from 0.05mm to 3mm in size.
22. The augmented disc of claim 18 wherein said collagen-based material comprises particles ranging from 0.05mm to 1mm in size.
23. The augmented disc of claim 18 wherein said collagen-based material comprises particles ranging from 0.25mm to 1mm in size.
24. The augmented disc of claim 18 wherein said collagen-based material comprises collagen-based materials that have been reconstituted in the disc from dehydrated collagen-based materials.
25. The augmented disc of claim 18 wherein said collagen-based material comprises collagen-based materials that were injected into the disc in a non-dehydrated state.
26. The augmented disc of claim 18 wherein said collagen-based material comprises collagen-based materials that were injected into the disc as a gel.
27. The augmented disc of claim 18 wherein said collagen-based material comprises collagen-based materials that were injected into the disc as a solution or suspension.
28. The augmented disc of claim 18 wherein said collagen-based material additionally includes a cross-linking agent to promote crosslinking of collagen molecules.
29. The augmented disc of claim 18 wherein said collagen-based material additionally includes a radiocontrast media.
30. The augmented disc of claim 18 wherein said collagen-based material additionally includes an analgesic.
31. The augmented disc of claim 18 wherein said collagen-based material additionally includes an antibiotic.
32. The augmented disc of claim 18 wherein said collagen-based material additionally includes proteoglycans.
33. The augmented disc of claim 18 wherein said collagen-based material additionally includes growth factors.
34. The augmented disc of claim 18 wherein said collagen-based material additionally includes one or more other types of cells effective to promote healing, repair, regeneration and/or restoration of the disc, and/or to facilitate proper disc function.
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PCT/US2003/029278 WO2004026189A2 (en) | 2002-09-18 | 2003-09-16 | Collagen-based materials and methods for augmenting intervertebral discs |
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CA002505169A Abandoned CA2505169A1 (en) | 2002-09-18 | 2003-11-10 | Collagen-based materials and methods for treating synovial joints |
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Families Citing this family (157)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
HU228630B1 (en) * | 1996-02-09 | 2013-04-29 | Abbott Biotech Ltd | Use of human anti bodies that bind human tnf-alpha and process for inhibiting of human tnf-alpha activity |
US7435260B2 (en) * | 1999-08-13 | 2008-10-14 | Ferree Bret A | Use of morphogenetic proteins to treat human disc disease |
US7052516B2 (en) | 1999-10-20 | 2006-05-30 | Anulex Technologies, Inc. | Spinal disc annulus reconstruction method and deformable spinal disc annulus stent |
US8128698B2 (en) | 1999-10-20 | 2012-03-06 | Anulex Technologies, Inc. | Method and apparatus for the treatment of the intervertebral disc annulus |
US8632590B2 (en) | 1999-10-20 | 2014-01-21 | Anulex Technologies, Inc. | Apparatus and methods for the treatment of the intervertebral disc |
US6592625B2 (en) | 1999-10-20 | 2003-07-15 | Anulex Technologies, Inc. | Spinal disc annulus reconstruction method and spinal disc annulus stent |
US7004970B2 (en) | 1999-10-20 | 2006-02-28 | Anulex Technologies, Inc. | Methods and devices for spinal disc annulus reconstruction and repair |
US7615076B2 (en) | 1999-10-20 | 2009-11-10 | Anulex Technologies, Inc. | Method and apparatus for the treatment of the intervertebral disc annulus |
US20030153976A1 (en) * | 1999-10-20 | 2003-08-14 | Cauthen Joseph C. | Spinal disc annulus reconstruction method and spinal disc annulus stent |
US7935147B2 (en) | 1999-10-20 | 2011-05-03 | Anulex Technologies, Inc. | Method and apparatus for enhanced delivery of treatment device to the intervertebral disc annulus |
US7951201B2 (en) | 1999-10-20 | 2011-05-31 | Anulex Technologies, Inc. | Method and apparatus for the treatment of the intervertebral disc annulus |
US6805695B2 (en) | 2000-04-04 | 2004-10-19 | Spinalabs, Llc | Devices and methods for annular repair of intervertebral discs |
AU5326701A (en) * | 2000-04-05 | 2001-10-23 | Kyphon Inc | Methods and devices for treating fractured and/or diseased bone |
US6723335B1 (en) * | 2000-04-07 | 2004-04-20 | Jeffrey William Moehlenbruck | Methods and compositions for treating intervertebral disc degeneration |
MXPA04005707A (en) * | 2001-12-10 | 2005-06-20 | Colbar Lifescience Ltd D | Methods, devices, and preparations for intervertebral disc treatment. |
US20050209699A1 (en) * | 2002-03-19 | 2005-09-22 | Slivka Michael A | Method for nonsurgical treatment of the nucleus pulposus of the intervertebral disc using genipin or proanthrocyanidin, and kit therefor |
US6812211B2 (en) * | 2002-03-19 | 2004-11-02 | Michael Andrew Slivka | Method for nonsurgical treatment of the intervertebral disc and kit therefor |
US20040054414A1 (en) | 2002-09-18 | 2004-03-18 | Trieu Hai H. | Collagen-based materials and methods for augmenting intervertebral discs |
US7744651B2 (en) * | 2002-09-18 | 2010-06-29 | Warsaw Orthopedic, Inc | Compositions and methods for treating intervertebral discs with collagen-based materials |
US7309359B2 (en) * | 2003-08-21 | 2007-12-18 | Warsaw Orthopedic, Inc. | Allogenic/xenogenic implants and methods for augmenting or repairing intervertebral discs |
US7887593B2 (en) | 2002-09-18 | 2011-02-15 | Warsaw Orthopedic, Inc. | Method of implanting natural tissue within the vertebral disc nucleus space using a drawstring |
CA2735334A1 (en) * | 2002-11-05 | 2004-05-21 | Spineology, Inc. | A semi-biological intervertebral disc replacement system |
JP2006515765A (en) | 2002-11-15 | 2006-06-08 | エスディージーアイ・ホールディングス・インコーポレーテッド | Collagen-based materials and methods for treating synovial joints |
US20040186471A1 (en) * | 2002-12-07 | 2004-09-23 | Sdgi Holdings, Inc. | Method and apparatus for intervertebral disc expansion |
CA2513055A1 (en) * | 2003-01-31 | 2004-08-19 | Zimmer Orthobiologics, Inc. | Hydrogel compositions comprising nucleus pulposus tissue |
AU2004212942A1 (en) | 2003-02-14 | 2004-09-02 | Depuy Spine, Inc. | In-situ formed intervertebral fusion device |
US7648509B2 (en) * | 2003-03-10 | 2010-01-19 | Ilion Medical Llc | Sacroiliac joint immobilization |
WO2004089240A2 (en) * | 2003-04-04 | 2004-10-21 | Theken Disc, Llc | Artificial disc prosthesis |
WO2006002417A2 (en) * | 2004-06-22 | 2006-01-05 | Yeung Jeffrey E | Disc shunt for treating back pain |
US20050131417A1 (en) * | 2003-08-22 | 2005-06-16 | Ahern James W. | Kit for treating bony defects |
US20050071012A1 (en) * | 2003-09-30 | 2005-03-31 | Hassan Serhan | Methods and devices to replace spinal disc nucleus pulposus |
ES2396689T3 (en) | 2003-12-11 | 2013-02-25 | Isto Technologies Inc. | Particle Cartilage System |
US7824390B2 (en) | 2004-04-16 | 2010-11-02 | Kyphon SÀRL | Spinal diagnostic methods and apparatus |
US7452351B2 (en) * | 2004-04-16 | 2008-11-18 | Kyphon Sarl | Spinal diagnostic methods and apparatus |
ZA200610272B (en) * | 2004-05-21 | 2008-07-30 | Synthes Gmbh | Replacement of nucleus pulposus using a hydrogel |
US20050277921A1 (en) * | 2004-05-28 | 2005-12-15 | Sdgi Holdings, Inc. | Prosthetic joint and nucleus supplement |
US8512730B2 (en) | 2004-07-12 | 2013-08-20 | Isto Technologies, Inc. | Methods of tissue repair and compositions therefor |
WO2006015001A1 (en) * | 2004-07-27 | 2006-02-09 | Synthes (U.S.A.) | Supplementation or replacement of a nucleus pulposus, of an intervertebral disc |
EP1788986A1 (en) * | 2004-08-30 | 2007-05-30 | Spineovations, Inc. | Method of treating spinal internal disk derangement |
EP1784145B1 (en) * | 2004-08-30 | 2011-08-10 | Neville Alleyne | Implant for the treatment of ligaments and tendons |
US8697139B2 (en) | 2004-09-21 | 2014-04-15 | Frank M. Phillips | Method of intervertebral disc treatment using articular chondrocyte cells |
EA011594B1 (en) * | 2004-12-30 | 2009-04-28 | Синвеншен Аг | Combination comprising an agent providing a signal, an implant material and a drug |
US7825083B2 (en) * | 2005-02-10 | 2010-11-02 | Spine Wave, Inc. | Synovial fluid barrier |
CA2604622A1 (en) * | 2005-04-15 | 2006-10-26 | Musculoskeletal Transplant Foundation | Vertebral disc repair |
US20060241758A1 (en) * | 2005-04-20 | 2006-10-26 | Sdgi Holdings, Inc. | Facet spacers |
US8080061B2 (en) * | 2005-06-20 | 2011-12-20 | Synthes Usa, Llc | Apparatus and methods for treating bone |
JP4907908B2 (en) * | 2005-06-29 | 2012-04-04 | ルネサスエレクトロニクス株式会社 | Driving circuit and display device |
AU2006279558B2 (en) | 2005-08-16 | 2012-05-17 | Izi Medical Products, Llc | Spinal tissue distraction devices |
US8591583B2 (en) | 2005-08-16 | 2013-11-26 | Benvenue Medical, Inc. | Devices for treating the spine |
US8366773B2 (en) | 2005-08-16 | 2013-02-05 | Benvenue Medical, Inc. | Apparatus and method for treating bone |
JP5292533B2 (en) | 2005-08-26 | 2013-09-18 | ジンマー・インコーポレイテッド | Implant and joint disease treatment, replacement and treatment methods |
US8197545B2 (en) * | 2005-10-27 | 2012-06-12 | Depuy Spine, Inc. | Nucleus augmentation delivery device and technique |
US8801790B2 (en) * | 2005-12-27 | 2014-08-12 | Warsaw Orthopedic, Inc. | Intervertebral disc augmentation and rehydration with superabsorbent polymers |
US8506633B2 (en) * | 2005-12-27 | 2013-08-13 | Warsaw Orthopedic, Inc. | Rehydration and restoration of intervertebral discs with polyelectrolytes |
US20070191861A1 (en) * | 2006-01-30 | 2007-08-16 | Sdgi Holdings, Inc. | Instruments and methods for implanting nucleus replacement material in an intervertebral disc nucleus space |
US20070213718A1 (en) * | 2006-02-14 | 2007-09-13 | Sdgi Holdings, Inc. | Treatment of the vertebral column |
US20070227547A1 (en) * | 2006-02-14 | 2007-10-04 | Sdgi Holdings, Inc. | Treatment of the vertebral column |
US20070213717A1 (en) * | 2006-02-14 | 2007-09-13 | Sdgi Holdings, Inc. | Biological fusion in the vertebral column |
US7520888B2 (en) * | 2006-02-14 | 2009-04-21 | Warsaw Orthopedic, Inc. | Treatment of the vertebral column |
US8016859B2 (en) | 2006-02-17 | 2011-09-13 | Medtronic, Inc. | Dynamic treatment system and method of use |
US8679809B2 (en) * | 2006-05-19 | 2014-03-25 | The University Of Hong Kong | Cell-matrix microspheres, methods for preparation and applications |
US20070293428A1 (en) * | 2006-06-19 | 2007-12-20 | Zanella John M | Methods of treating joint pain in a subject by using an anti-angiogenic agent |
US20080004703A1 (en) * | 2006-06-30 | 2008-01-03 | Warsaw Orthopedic, Inc. | Method of treating a patient using a collagen material |
US8399619B2 (en) * | 2006-06-30 | 2013-03-19 | Warsaw Orthopedic, Inc. | Injectable collagen material |
US20080004431A1 (en) * | 2006-06-30 | 2008-01-03 | Warsaw Orthopedic Inc | Method of manufacturing an injectable collagen material |
US8118779B2 (en) * | 2006-06-30 | 2012-02-21 | Warsaw Orthopedic, Inc. | Collagen delivery device |
US7959683B2 (en) * | 2006-07-25 | 2011-06-14 | Musculoskeletal Transplant Foundation | Packed demineralized cancellous tissue forms for disc nucleus augmentation, restoration, or replacement and methods of implantation |
US20080058954A1 (en) * | 2006-08-22 | 2008-03-06 | Hai Trieu | Methods of treating spinal injuries using injectable flowable compositions comprising organic materials |
US20080064626A1 (en) * | 2006-09-08 | 2008-03-13 | Zanella John M | Methods of treating tendonitis in a subject by using an anti-cytokine agent |
WO2008051864A2 (en) * | 2006-10-24 | 2008-05-02 | Neville Alleyne | Method of treating spinal internal disk derangement |
US8057458B2 (en) * | 2006-10-30 | 2011-11-15 | Warsaw Orthopedic, Inc. | Method for treating facet pain |
US8105382B2 (en) | 2006-12-07 | 2012-01-31 | Interventional Spine, Inc. | Intervertebral implant |
US8163549B2 (en) | 2006-12-20 | 2012-04-24 | Zimmer Orthobiologics, Inc. | Method of obtaining viable small tissue particles and use for tissue repair |
WO2008103832A2 (en) | 2007-02-21 | 2008-08-28 | Benvenue Medical, Inc. | Devices for treating the spine |
US20080255664A1 (en) | 2007-04-10 | 2008-10-16 | Mdesign International | Percutaneously deliverable orthopedic joint device |
JP5328763B2 (en) * | 2007-04-10 | 2013-10-30 | アーティキュリンクス, インコーポレイテッド | Percutaneous delivery and retrieval system for a shape change orthopedic joint device |
WO2008128075A1 (en) | 2007-04-12 | 2008-10-23 | Isto Technologies, Inc. | Compositions and methods for tissue repair |
US8864801B2 (en) * | 2007-04-30 | 2014-10-21 | Warsaw Orthopedic, Inc. | Method of deformity correction in a spine using injectable materials |
US20080299172A1 (en) * | 2007-06-04 | 2008-12-04 | Stuart Young | Tissue repair implant |
US8900307B2 (en) | 2007-06-26 | 2014-12-02 | DePuy Synthes Products, LLC | Highly lordosed fusion cage |
US20090024174A1 (en) | 2007-07-17 | 2009-01-22 | Stark John G | Bone screws and particular applications to sacroiliac joint fusion |
US20090093852A1 (en) * | 2007-10-05 | 2009-04-09 | Hynes Richard A | Spinal stabilization treatment methods for maintaining axial spine height and sagital plane spine balance |
CA2710142A1 (en) | 2008-01-17 | 2009-07-23 | Beat Lechmann | An expandable intervertebral implant and associated method of manufacturing the same |
US8740912B2 (en) | 2008-02-27 | 2014-06-03 | Ilion Medical Llc | Tools for performing less invasive orthopedic joint procedures |
US20100004700A1 (en) * | 2008-03-05 | 2010-01-07 | Neville Alleyne | Method of treating tissue with a suspenson of tricalcium hydroxyapatite microspheres |
US8469961B2 (en) * | 2008-03-05 | 2013-06-25 | Neville Alleyne | Methods and compositions for minimally invasive capsular augmentation of canine coxofemoral joints |
US20100010549A1 (en) * | 2008-03-05 | 2010-01-14 | Neville Alleyne | device and method of minimally invasive extracapsular ligamentous augmentation for canine stifle ligament injuries |
WO2009124269A1 (en) | 2008-04-05 | 2009-10-08 | Synthes Usa, Llc | Expandable intervertebral implant |
US7976578B2 (en) * | 2008-06-04 | 2011-07-12 | James Marvel | Buffer for a human joint and method of arthroscopically inserting |
US8163022B2 (en) | 2008-10-14 | 2012-04-24 | Anulex Technologies, Inc. | Method and apparatus for the treatment of the intervertebral disc annulus |
US8974502B2 (en) * | 2008-10-30 | 2015-03-10 | Warsaw Orthopedic, Inc. | Methods, systems, and devices for treating intervertebral discs including intradiscal fluid evacuation |
US8702677B2 (en) * | 2008-10-31 | 2014-04-22 | Warsaw Orthopedic, Inc. | Device and method for directional delivery of a drug depot |
US8535327B2 (en) | 2009-03-17 | 2013-09-17 | Benvenue Medical, Inc. | Delivery apparatus for use with implantable medical devices |
US9526620B2 (en) | 2009-03-30 | 2016-12-27 | DePuy Synthes Products, Inc. | Zero profile spinal fusion cage |
US9414864B2 (en) * | 2009-04-15 | 2016-08-16 | Warsaw Orthopedic, Inc. | Anterior spinal plate with preformed drug-eluting device affixed thereto |
US8715223B2 (en) * | 2009-07-22 | 2014-05-06 | Warsaw Orthopedic, Inc. | Device and method for delivery of a drug depot near the nerve |
US8292954B2 (en) | 2009-09-11 | 2012-10-23 | Articulinx, Inc. | Disc-based orthopedic devices |
US9132207B2 (en) | 2009-10-27 | 2015-09-15 | Spine Wave, Inc. | Radiopaque injectable nucleus hydrogel compositions |
US9393129B2 (en) | 2009-12-10 | 2016-07-19 | DePuy Synthes Products, Inc. | Bellows-like expandable interbody fusion cage |
US8657859B2 (en) * | 2009-12-16 | 2014-02-25 | Advanced Veterinary Solutions | Implant for promoting stability of the canine stifle joint |
US8652153B2 (en) | 2010-01-11 | 2014-02-18 | Anulex Technologies, Inc. | Intervertebral disc annulus repair system and bone anchor delivery tool |
ES2614919T3 (en) | 2010-01-13 | 2017-06-02 | Jcbd, Llc | Fixation and fusion system of the sacroiliac joint |
US9333090B2 (en) | 2010-01-13 | 2016-05-10 | Jcbd, Llc | Systems for and methods of fusing a sacroiliac joint |
US9788961B2 (en) | 2010-01-13 | 2017-10-17 | Jcbd, Llc | Sacroiliac joint implant system |
US9421109B2 (en) | 2010-01-13 | 2016-08-23 | Jcbd, Llc | Systems and methods of fusing a sacroiliac joint |
US9381045B2 (en) | 2010-01-13 | 2016-07-05 | Jcbd, Llc | Sacroiliac joint implant and sacroiliac joint instrument for fusing a sacroiliac joint |
US9554909B2 (en) | 2012-07-20 | 2017-01-31 | Jcbd, Llc | Orthopedic anchoring system and methods |
US8979860B2 (en) | 2010-06-24 | 2015-03-17 | DePuy Synthes Products. LLC | Enhanced cage insertion device |
US9592063B2 (en) | 2010-06-24 | 2017-03-14 | DePuy Synthes Products, Inc. | Universal trial for lateral cages |
WO2012003175A1 (en) | 2010-06-29 | 2012-01-05 | Synthes Usa, Llc | Distractible intervertebral implant |
US9402732B2 (en) | 2010-10-11 | 2016-08-02 | DePuy Synthes Products, Inc. | Expandable interspinous process spacer implant |
US20120116515A1 (en) * | 2010-10-25 | 2012-05-10 | Semler Eric J | Demineralized cortical bone implants |
US9358122B2 (en) | 2011-01-07 | 2016-06-07 | K2M, Inc. | Interbody spacer |
US8814873B2 (en) | 2011-06-24 | 2014-08-26 | Benvenue Medical, Inc. | Devices and methods for treating bone tissue |
US20130018467A1 (en) * | 2011-07-15 | 2013-01-17 | Sean Suh | Systems and Methods For Vertebral Body and Disc Height Restoration |
US20130282121A1 (en) * | 2012-03-22 | 2013-10-24 | Ann Prewett | Spinal facet augmentation implant and method |
US10179014B1 (en) | 2012-06-01 | 2019-01-15 | Nuvasive, Inc. | Systems and methods for promoting sacroiliac joint fusion |
US9307968B2 (en) * | 2012-06-15 | 2016-04-12 | The University Of Hong Kong | Materials and methods for filling biological cavities and preventing leakage of injected therapeutic agents |
US10245306B2 (en) | 2012-11-16 | 2019-04-02 | Isto Technologies Ii, Llc | Flexible tissue matrix and methods for joint repair |
US20140178343A1 (en) | 2012-12-21 | 2014-06-26 | Jian Q. Yao | Supports and methods for promoting integration of cartilage tissue explants |
US10179012B2 (en) | 2013-01-28 | 2019-01-15 | Cartiva, Inc. | Systems and methods for orthopedic repair |
US9737294B2 (en) | 2013-01-28 | 2017-08-22 | Cartiva, Inc. | Method and system for orthopedic repair |
US9522070B2 (en) | 2013-03-07 | 2016-12-20 | Interventional Spine, Inc. | Intervertebral implant |
US10085783B2 (en) | 2013-03-14 | 2018-10-02 | Izi Medical Products, Llc | Devices and methods for treating bone tissue |
US10245087B2 (en) | 2013-03-15 | 2019-04-02 | Jcbd, Llc | Systems and methods for fusing a sacroiliac joint and anchoring an orthopedic appliance |
US9717539B2 (en) | 2013-07-30 | 2017-08-01 | Jcbd, Llc | Implants, systems, and methods for fusing a sacroiliac joint |
US9826986B2 (en) | 2013-07-30 | 2017-11-28 | Jcbd, Llc | Systems for and methods of preparing a sacroiliac joint for fusion |
US9119732B2 (en) | 2013-03-15 | 2015-09-01 | Orthocision, Inc. | Method and implant system for sacroiliac joint fixation and fusion |
US9510872B2 (en) | 2013-03-15 | 2016-12-06 | Jcbd, Llc | Spinal stabilization system |
WO2015017593A1 (en) | 2013-07-30 | 2015-02-05 | Jcbd, Llc | Systems for and methods of fusing a sacroiliac joint |
US9539041B2 (en) | 2013-09-12 | 2017-01-10 | DePuy Synthes Products, Inc. | Minimally invasive biomaterial injection system |
US9801546B2 (en) | 2014-05-27 | 2017-10-31 | Jcbd, Llc | Systems for and methods of diagnosing and treating a sacroiliac joint disorder |
US10064896B2 (en) | 2014-07-17 | 2018-09-04 | Vivex Biomedical, Inc. | Spinal disc regenerative composition and method of manufacture and use |
US9764122B2 (en) | 2014-07-25 | 2017-09-19 | Warsaw Orthopedic, Inc. | Drug delivery device and methods having an occluding member |
US9775978B2 (en) | 2014-07-25 | 2017-10-03 | Warsaw Orthopedic, Inc. | Drug delivery device and methods having a retaining member |
US10179191B2 (en) | 2014-10-09 | 2019-01-15 | Isto Technologies Ii, Llc | Flexible tissue matrix and methods for joint repair |
US10136958B2 (en) | 2014-10-28 | 2018-11-27 | Amendia, Inc. | Tissue protector and method of use |
US9238090B1 (en) | 2014-12-24 | 2016-01-19 | Fettech, Llc | Tissue-based compositions |
SG10201906601TA (en) | 2015-01-16 | 2019-09-27 | Spineovations Inc | Method of treating spinal disk |
US11426290B2 (en) | 2015-03-06 | 2022-08-30 | DePuy Synthes Products, Inc. | Expandable intervertebral implant, system, kit and method |
US11052175B2 (en) | 2015-08-19 | 2021-07-06 | Musculoskeletal Transplant Foundation | Cartilage-derived implants and methods of making and using same |
US10076650B2 (en) | 2015-11-23 | 2018-09-18 | Warsaw Orthopedic, Inc. | Enhanced stylet for drug depot injector |
US10549081B2 (en) | 2016-06-23 | 2020-02-04 | Warsaw Orthopedic, Inc. | Drug delivery device and methods having a retaining member |
CN109688981A (en) | 2016-06-28 | 2019-04-26 | Eit 新兴移植技术股份有限公司 | Distensible, adjustable angle intervertebral cage |
CN109688980B (en) | 2016-06-28 | 2022-06-10 | Eit 新兴移植技术股份有限公司 | Expandable and angularly adjustable intervertebral cage with articulation joint |
US10434261B2 (en) | 2016-11-08 | 2019-10-08 | Warsaw Orthopedic, Inc. | Drug pellet delivery system and method |
US10888433B2 (en) | 2016-12-14 | 2021-01-12 | DePuy Synthes Products, Inc. | Intervertebral implant inserter and related methods |
US10645921B2 (en) | 2016-12-20 | 2020-05-12 | Vivex Biologics Group, Inc. | Viable disc regenerative composition and method of manufacture and use |
US10398563B2 (en) | 2017-05-08 | 2019-09-03 | Medos International Sarl | Expandable cage |
US11344424B2 (en) | 2017-06-14 | 2022-05-31 | Medos International Sarl | Expandable intervertebral implant and related methods |
US10940016B2 (en) | 2017-07-05 | 2021-03-09 | Medos International Sarl | Expandable intervertebral fusion cage |
US10603055B2 (en) | 2017-09-15 | 2020-03-31 | Jcbd, Llc | Systems for and methods of preparing and fusing a sacroiliac joint |
US11951231B2 (en) | 2018-01-31 | 2024-04-09 | Kinki University | Therapeutic agent for intervertebral disc degeneration and material for culturing inter vertebral disc cells |
US11446156B2 (en) | 2018-10-25 | 2022-09-20 | Medos International Sarl | Expandable intervertebral implant, inserter instrument, and related methods |
US11426286B2 (en) | 2020-03-06 | 2022-08-30 | Eit Emerging Implant Technologies Gmbh | Expandable intervertebral implant |
US11850160B2 (en) | 2021-03-26 | 2023-12-26 | Medos International Sarl | Expandable lordotic intervertebral fusion cage |
US11752009B2 (en) | 2021-04-06 | 2023-09-12 | Medos International Sarl | Expandable intervertebral fusion cage |
Family Cites Families (249)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US788625A (en) * | 1903-05-04 | 1905-05-02 | George C Blackmore | Floor or ceiling plate for pipes. |
US3551560A (en) * | 1967-10-02 | 1970-12-29 | Heinrich F Thiele | Process of reconstructing tendons,cartilage,nerve sheaths,and products |
CA962806A (en) * | 1970-06-04 | 1975-02-18 | Ontario Research Foundation | Surgical prosthetic device |
US3875595A (en) * | 1974-04-15 | 1975-04-08 | Edward C Froning | Intervertebral disc prosthesis and instruments for locating same |
US4085466A (en) * | 1974-11-18 | 1978-04-25 | National Research Development Corporation | Prosthetic joint device |
US4280954A (en) * | 1975-07-15 | 1981-07-28 | Massachusetts Institute Of Technology | Crosslinked collagen-mucopolysaccharide composite materials |
US4060081A (en) * | 1975-07-15 | 1977-11-29 | Massachusetts Institute Of Technology | Multilayer membrane useful as synthetic skin |
US4185813A (en) | 1978-05-17 | 1980-01-29 | Spann Donald C | Surgical body positioner |
CA1146301A (en) * | 1980-06-13 | 1983-05-17 | J. David Kuntz | Intervertebral disc prosthesis |
US4378224A (en) * | 1980-09-19 | 1983-03-29 | Nimni Marcel E | Coating for bioprosthetic device and method of making same |
US4344193A (en) * | 1980-11-28 | 1982-08-17 | Kenny Charles H | Meniscus prosthesis |
US4400833A (en) * | 1981-06-10 | 1983-08-30 | Kurland Kenneth Z | Means and method of implanting bioprosthetics |
US4350629A (en) * | 1981-07-29 | 1982-09-21 | Massachusetts Institute Of Technology | Procedures for preparing composite materials from collagen and glycosaminoglycan |
US4505266A (en) * | 1981-10-26 | 1985-03-19 | Massachusetts Institute Of Technology | Method of using a fibrous lattice |
US4418691A (en) * | 1981-10-26 | 1983-12-06 | Massachusetts Institute Of Technology | Method of promoting the regeneration of tissue at a wound |
US4458678A (en) * | 1981-10-26 | 1984-07-10 | Massachusetts Institute Of Technology | Cell-seeding procedures involving fibrous lattices |
US4424208A (en) | 1982-01-11 | 1984-01-03 | Collagen Corporation | Collagen implant material and method for augmenting soft tissue |
US4582640A (en) | 1982-03-08 | 1986-04-15 | Collagen Corporation | Injectable cross-linked collagen implant material |
US4787900A (en) * | 1982-04-19 | 1988-11-29 | Massachusetts Institute Of Technology | Process for forming multilayer bioreplaceable blood vessel prosthesis |
US4544516A (en) * | 1982-07-28 | 1985-10-01 | Battelle Development Corporation | Collagen orientation |
US4589881A (en) * | 1982-08-04 | 1986-05-20 | La Jolla Cancer Research Foundation | Polypeptide |
US4661111A (en) * | 1982-08-04 | 1987-04-28 | La Jolla Cancer Research Foundation | Polypeptide |
US4578079A (en) * | 1982-08-04 | 1986-03-25 | La Jolla Cancer Research Foundation | Tetrapeptide |
IL68218A (en) * | 1983-03-23 | 1985-12-31 | Univ Ramot | Compositions for cartilage repair comprising embryonal chondrocytes |
US4801299A (en) * | 1983-06-10 | 1989-01-31 | University Patents, Inc. | Body implants of extracellular matrix and means and methods of making and using such implants |
WO1985000511A1 (en) * | 1983-07-25 | 1985-02-14 | Medlen John C | Collagen ligament and tendon regeneration method and material |
US4448718A (en) * | 1983-09-13 | 1984-05-15 | Massachusetts Institute Of Technology | Method for the preparation of collagen-glycosaminoglycan composite materials |
GB2148901A (en) * | 1983-10-04 | 1985-06-05 | Johnson & Johnson | Protein/polysaccharide complexes |
US4837285A (en) * | 1984-03-27 | 1989-06-06 | Medimatrix | Collagen matrix beads for soft tissue repair |
CA1295796C (en) * | 1984-03-27 | 1992-02-18 | Conrad Whyne | Biodegradable matrix and methods for producing same |
US4879135A (en) * | 1984-07-23 | 1989-11-07 | University Of Medicine And Dentistry Of New Jersey | Drug bonded prosthesis and process for producing same |
US4642117A (en) | 1985-03-22 | 1987-02-10 | Collagen Corporation | Mechanically sheared collagen implant material and method |
US4627853A (en) * | 1985-05-29 | 1986-12-09 | American Hospital Supply Corporation | Method of producing prostheses for replacement of articular cartilage and prostheses so produced |
US4803075A (en) | 1986-06-25 | 1989-02-07 | Collagen Corporation | Injectable implant composition having improved intrudability |
DE3631469A1 (en) * | 1986-09-16 | 1988-03-17 | Merck Patent Gmbh | METAL ORGANIC COMPOUNDS |
US5258043A (en) * | 1987-07-20 | 1993-11-02 | Regen Corporation | Method for making a prosthetic intervertebral disc |
US5108438A (en) * | 1989-03-02 | 1992-04-28 | Regen Corporation | Prosthetic intervertebral disc |
US5007934A (en) * | 1987-07-20 | 1991-04-16 | Regen Corporation | Prosthetic meniscus |
US4772287A (en) * | 1987-08-20 | 1988-09-20 | Cedar Surgical, Inc. | Prosthetic disc and method of implanting |
US4907260A (en) * | 1987-10-05 | 1990-03-06 | Ambassador College | Telephone line communications control system |
US4976733A (en) * | 1988-02-03 | 1990-12-11 | Biomedical Design, Inc. | Prevention of prosthesis calcification |
US5067962A (en) * | 1989-04-18 | 1991-11-26 | Baxter International Inc. | Bioprosthetic ligament |
US4946792A (en) * | 1989-08-18 | 1990-08-07 | Osteotech, Inc. | Process for debriding bone |
US5106949A (en) * | 1989-09-15 | 1992-04-21 | Organogenesis, Inc. | Collagen compositions and methods for preparation thereof |
US5229497A (en) * | 1990-10-03 | 1993-07-20 | Teepak, Inc. | Process for recovering collagen |
US5137514A (en) | 1990-11-01 | 1992-08-11 | Accumed Systems, Inc. | Inflation syringe assembly for percutaneous transluminal angioplasty |
US5192326A (en) * | 1990-12-21 | 1993-03-09 | Pfizer Hospital Products Group, Inc. | Hydrogel bead intervertebral disc nucleus |
US5605938A (en) * | 1991-05-31 | 1997-02-25 | Gliatech, Inc. | Methods and compositions for inhibition of cell invasion and fibrosis using dextran sulfate |
US5713960A (en) * | 1991-07-06 | 1998-02-03 | Christensen; James Marlow | Prosthesis with improved biocompatibility made with N-vinyl polymers |
DE4125400C2 (en) * | 1991-07-31 | 2000-08-17 | Edwin Klaus | Use of insoluble collagen for the treatment of degenerative, non-inflammatory joint processes |
US5507810A (en) * | 1991-10-07 | 1996-04-16 | Osteotech, Inc. | Processing of fibrous connective tissue |
US6277112B1 (en) | 1996-07-16 | 2001-08-21 | Arthrocare Corporation | Methods for electrosurgical spine surgery |
US5658593A (en) * | 1992-01-16 | 1997-08-19 | Coletica | Injectable compositions containing collagen microcapsules |
US5391203A (en) * | 1992-04-13 | 1995-02-21 | Scott P. Bartlett | Method of draining and filling soft tissue implant |
US5478739A (en) * | 1992-10-23 | 1995-12-26 | Advanced Tissue Sciences, Inc. | Three-dimensional stromal cell and tissue culture system |
US5397352A (en) | 1993-08-27 | 1995-03-14 | Burres; Steven | Method of recollagenation |
US6248110B1 (en) | 1994-01-26 | 2001-06-19 | Kyphon, Inc. | Systems and methods for treating fractured or diseased bone using expandable bodies |
RU2147213C1 (en) | 1994-01-26 | 2000-04-10 | А. Рейли Марк | Improved filled device for use in surgical protocol as applied to bone fixation |
EP0741547B1 (en) | 1994-01-26 | 2005-04-20 | Kyphon Inc. | Improved inflatable device for use in surgical protocol relating to fixation of bone |
US7166121B2 (en) | 1994-01-26 | 2007-01-23 | Kyphon Inc. | Systems and methods using expandable bodies to push apart cortical bone surfaces |
US6716216B1 (en) * | 1998-08-14 | 2004-04-06 | Kyphon Inc. | Systems and methods for treating vertebral bodies |
US6140452A (en) * | 1994-05-06 | 2000-10-31 | Advanced Bio Surfaces, Inc. | Biomaterial for in situ tissue repair |
US5888220A (en) | 1994-05-06 | 1999-03-30 | Advanced Bio Surfaces, Inc. | Articulating joint repair |
US6248131B1 (en) | 1994-05-06 | 2001-06-19 | Advanced Bio Surfaces, Inc. | Articulating joint repair |
US5571189A (en) | 1994-05-20 | 1996-11-05 | Kuslich; Stephen D. | Expandable fabric implant for stabilizing the spinal motion segment |
US5906827A (en) | 1994-06-03 | 1999-05-25 | Creative Biomolecules, Inc. | Matrix for the manufacture of autogenous replacement body parts |
SE9402528D0 (en) | 1994-07-19 | 1994-07-19 | Astra Ab | Hard tissue stimulant with electricity |
US5935849A (en) * | 1994-07-20 | 1999-08-10 | Cytotherapeutics, Inc. | Methods and compositions of growth control for cells encapsulated within bioartificial organs |
US5776747A (en) * | 1994-07-20 | 1998-07-07 | Cytotherapeutics, Inc. | Method for controlling the distribution of cells within a bioartificial organ using polycthylene oxide-poly (dimethylsiloxane) copolymer |
ATE203885T1 (en) | 1994-09-08 | 2001-08-15 | Stryker Technologies Corp | HYDROGEL DISC CORE |
US5562736A (en) * | 1994-10-17 | 1996-10-08 | Raymedica, Inc. | Method for surgical implantation of a prosthetic spinal disc nucleus |
JPH10507386A (en) | 1994-10-17 | 1998-07-21 | レイメディカ, インコーポレイテッド | Artificial spinal disc nucleus |
EP0713707A1 (en) | 1994-11-23 | 1996-05-29 | Collagen Corporation | In situ crosslinkable, injectable collagen composition for tissue augmention |
US6080194A (en) * | 1995-02-10 | 2000-06-27 | The Hospital For Joint Disease Orthopaedic Institute | Multi-stage collagen-based template or implant for use in the repair of cartilage lesions |
US20050186673A1 (en) | 1995-02-22 | 2005-08-25 | Ed. Geistlich Soehne Ag Fuer Chemistrie Industrie | Collagen carrier of therapeutic genetic material, and method |
US5733337A (en) * | 1995-04-07 | 1998-03-31 | Organogenesis, Inc. | Tissue repair fabric |
US20020095218A1 (en) * | 1996-03-12 | 2002-07-18 | Carr Robert M. | Tissue repair fabric |
US6046379A (en) | 1995-06-07 | 2000-04-04 | Stone; Kevin R. | Meniscal xenografts |
CA2172917A1 (en) | 1995-06-07 | 1996-12-08 | Hugh R. Mcmullin | Moldable collagen compositions for hard tissue repair and augmentation |
US5980504A (en) * | 1996-08-13 | 1999-11-09 | Oratec Interventions, Inc. | Method for manipulating tissue of an intervertebral disc |
US6007570A (en) * | 1996-08-13 | 1999-12-28 | Oratec Interventions, Inc. | Apparatus with functional element for performing function upon intervertebral discs |
US6048964A (en) * | 1995-12-12 | 2000-04-11 | Stryker Corporation | Compositions and therapeutic methods using morphogenic proteins and stimulatory factors |
EP1704878B1 (en) | 1995-12-18 | 2013-04-10 | AngioDevice International GmbH | Crosslinked polymer compositions and methods for their use |
US6322786B1 (en) * | 1996-02-15 | 2001-11-27 | Kansas University Medical Center Research Institute, Inc. | Method of producing bone-inducing agent |
US6352558B1 (en) * | 1996-02-22 | 2002-03-05 | Ed. Geistlich Soehne Ag Fuer Chemische Industrie | Method for promoting regeneration of surface cartilage in a damage joint |
US5788625A (en) * | 1996-04-05 | 1998-08-04 | Depuy Orthopaedics, Inc. | Method of making reconstructive SIS structure for cartilaginous elements in situ |
EP0906128A1 (en) * | 1996-05-28 | 1999-04-07 | 1218122 Ontario Inc. | Resorbable implant biomaterial made of condensed calcium phosphate particles |
US5964807A (en) * | 1996-08-08 | 1999-10-12 | Trustees Of The University Of Pennsylvania | Compositions and methods for intervertebral disc reformation |
US6126682A (en) * | 1996-08-13 | 2000-10-03 | Oratec Interventions, Inc. | Method for treating annular fissures in intervertebral discs |
AU7178698A (en) | 1996-11-15 | 1998-06-03 | Advanced Bio Surfaces, Inc. | Biomaterial system for in situ tissue repair |
GB9704749D0 (en) * | 1997-03-07 | 1997-04-23 | Univ London | Tissue Implant |
US6022376A (en) * | 1997-06-06 | 2000-02-08 | Raymedica, Inc. | Percutaneous prosthetic spinal disc nucleus and method of manufacture |
FR2764514B1 (en) | 1997-06-13 | 1999-09-03 | Biopharmex Holding Sa | IMPLANT INJECTED IN SUBCUTANEOUS OR INTRADERMAL WITH CONTROLLED BIORESORBABILITY FOR REPAIR OR PLASTIC SURGERY AND AESTHETIC DERMATOLOGY |
GB9714580D0 (en) * | 1997-07-10 | 1997-09-17 | Wardlaw Douglas | Prosthetic intervertebral disc nucleus |
WO1999004720A1 (en) | 1997-07-11 | 1999-02-04 | Reprogenesis Inc. | Repair of intervertebral disks |
US6080579A (en) | 1997-11-26 | 2000-06-27 | Charlotte-Mecklenburg Hospital Authority | Method for producing human intervertebral disc cells |
US7045076B2 (en) | 1998-01-07 | 2006-05-16 | Sears Petroleum & Transport Corp. & Sears Ecological Applications Co., Llc | Deicing solution |
US6123731A (en) * | 1998-02-06 | 2000-09-26 | Osteotech, Inc. | Osteoimplant and method for its manufacture |
AU2798599A (en) * | 1998-02-27 | 1999-09-15 | Bioelastics Research Ltd. | Injectable implants for tissue augmentation and restoration |
US6179872B1 (en) | 1998-03-17 | 2001-01-30 | Tissue Engineering | Biopolymer matt for use in tissue repair and reconstruction |
WO1999059669A1 (en) | 1998-05-18 | 1999-11-25 | Bryan Vincent E Jr | Balloon jack |
US6224630B1 (en) * | 1998-05-29 | 2001-05-01 | Advanced Bio Surfaces, Inc. | Implantable tissue repair device |
WO2000007639A1 (en) | 1998-08-07 | 2000-02-17 | Tissue Engineering, Inc. | Bone precursor compositions |
US20010055594A1 (en) * | 1998-09-25 | 2001-12-27 | Kjell Olmarker | Use of certain drugs for treating nerve root injury |
SE9803710L (en) * | 1998-09-25 | 2000-03-26 | A & Science Invest Ab | Use of certain substances for the treatment of nerve root damage |
US6958149B2 (en) * | 1998-10-06 | 2005-10-25 | Stryker Corporation | Repair of larynx, trachea, and other fibrocartilaginous tissues |
US6025538A (en) * | 1998-11-20 | 2000-02-15 | Musculoskeletal Transplant Foundation | Compound bone structure fabricated from allograft tissue |
US20010006948A1 (en) * | 1998-11-25 | 2001-07-05 | James D. Kang | Gene transfer to intervertebral disc cells |
WO2000032250A1 (en) | 1998-12-01 | 2000-06-08 | Cook Biotech, Inc. | A multi-formed collagenous biomaterial medical device |
US6361551B1 (en) | 1998-12-11 | 2002-03-26 | C. R. Bard, Inc. | Collagen hemostatic fibers |
US6146422A (en) * | 1999-01-25 | 2000-11-14 | Lawson; Kevin Jon | Prosthetic nucleus replacement for surgical reconstruction of intervertebral discs and treatment method |
US6264659B1 (en) | 1999-02-22 | 2001-07-24 | Anthony C. Ross | Method of treating an intervertebral disk |
US6419944B2 (en) * | 1999-02-24 | 2002-07-16 | Edward L. Tobinick | Cytokine antagonists for the treatment of localized disorders |
US6197061B1 (en) | 1999-03-01 | 2001-03-06 | Koichi Masuda | In vitro production of transplantable cartilage tissue cohesive cartilage produced thereby, and method for the surgical repair of cartilage damage |
US6662805B2 (en) | 1999-03-24 | 2003-12-16 | The Johns Hopkins University | Method for composite cell-based implants |
US6428576B1 (en) * | 1999-04-16 | 2002-08-06 | Endospine, Ltd. | System for repairing inter-vertebral discs |
US6419702B1 (en) | 1999-08-13 | 2002-07-16 | Bret A. Ferree | Treating degenerative disc disease through transplantation of the nucleus pulposis |
US6340369B1 (en) * | 1999-08-13 | 2002-01-22 | Bret A. Ferree | Treating degenerative disc disease with harvested disc cells and analogues of the extracellular matrix |
US6969404B2 (en) | 1999-10-08 | 2005-11-29 | Ferree Bret A | Annulus fibrosis augmentation methods and apparatus |
SE9902155L (en) | 1999-06-09 | 2000-12-10 | Bjoern Rydevik | Serum antibodies |
FR2797179B1 (en) | 1999-08-03 | 2002-03-08 | Michel Gau | INTERVERTEBRAL NUCLEAR PROSTHESIS AND SURGICAL IMPLANTATION METHOD |
US6352557B1 (en) * | 1999-08-13 | 2002-03-05 | Bret A. Ferree | Treating degenerative disc disease through transplantion of extracellular nucleus pulposus matrix and autograft nucleus pulposus cells |
US6344058B1 (en) * | 1999-08-13 | 2002-02-05 | Bret A. Ferree | Treating degenerative disc disease through transplantation of allograft disc and vertebral endplates |
US6648918B2 (en) | 1999-08-13 | 2003-11-18 | Bret A. Ferree | Treating degenerative disc disease through the transplantation of dehydrated tissue |
US6793677B2 (en) | 1999-08-13 | 2004-09-21 | Bret A. Ferree | Method of providing cells and other biologic materials for transplantation |
US6936072B2 (en) | 1999-08-18 | 2005-08-30 | Intrinsic Therapeutics, Inc. | Encapsulated intervertebral disc prosthesis and methods of manufacture |
US6425919B1 (en) * | 1999-08-18 | 2002-07-30 | Intrinsic Orthopedics, Inc. | Devices and methods of vertebral disc augmentation |
US7553329B2 (en) | 1999-08-18 | 2009-06-30 | Intrinsic Therapeutics, Inc. | Stabilized intervertebral disc barrier |
CA2425951C (en) | 1999-08-18 | 2008-09-16 | Intrinsic Therapeutics, Inc. | Devices and method for nucleus pulposus augmentation and retention |
US6783546B2 (en) * | 1999-09-13 | 2004-08-31 | Keraplast Technologies, Ltd. | Implantable prosthetic or tissue expanding device |
US6436119B1 (en) | 1999-09-30 | 2002-08-20 | Raymedica, Inc. | Adjustable surgical dilator |
US6264695B1 (en) * | 1999-09-30 | 2001-07-24 | Replication Medical, Inc. | Spinal nucleus implant |
US6939329B1 (en) | 1999-10-08 | 2005-09-06 | Harvest Technologies Corporation | Apparatus for holding and operating one or more syringes |
US6878167B2 (en) | 2002-04-24 | 2005-04-12 | Bret A. Ferree | Methods and apparatus for placing intradiscal devices |
US6592625B2 (en) * | 1999-10-20 | 2003-07-15 | Anulex Technologies, Inc. | Spinal disc annulus reconstruction method and spinal disc annulus stent |
WO2003011155A2 (en) | 1999-10-20 | 2003-02-13 | Anulex Technologies, Inc. | Spinal disc annulus reconstruction method and spinal disc annulus stent |
US6309169B1 (en) * | 1999-11-04 | 2001-10-30 | Roper Holdings, Inc. | Pump deployment system |
DE19959975A1 (en) | 1999-12-13 | 2001-07-26 | Efmt Entwicklungs Und Forschun | Cannula serving as a passage for a medical instrument or a substance comprises an end section with a shape memory which is activated when a given transition temperature is reached |
US6623963B1 (en) * | 1999-12-20 | 2003-09-23 | Verigen Ag | Cellular matrix |
US7014633B2 (en) | 2000-02-16 | 2006-03-21 | Trans1, Inc. | Methods of performing procedures in the spine |
US6558390B2 (en) | 2000-02-16 | 2003-05-06 | Axiamed, Inc. | Methods and apparatus for performing therapeutic procedures in the spine |
AU5326701A (en) | 2000-04-05 | 2001-10-23 | Kyphon Inc | Methods and devices for treating fractured and/or diseased bone |
US6723335B1 (en) | 2000-04-07 | 2004-04-20 | Jeffrey William Moehlenbruck | Methods and compositions for treating intervertebral disc degeneration |
NZ521800A (en) | 2000-04-07 | 2004-06-25 | Kyphon Inc | Insertion devices and directing the expansion of an expandable structure of the device within a bone |
US6324710B1 (en) | 2000-04-14 | 2001-12-04 | Arthur S. Hernandez | Prone support apparatus for spinal procedures |
WO2004043303A2 (en) | 2002-11-12 | 2004-05-27 | Regenex Ltd. | Expandable devices and methods for tissue expansion, regenerationand fixation |
US6749614B2 (en) | 2000-06-23 | 2004-06-15 | Vertelink Corporation | Formable orthopedic fixation system with cross linking |
US20040083001A1 (en) | 2000-06-29 | 2004-04-29 | Rita Kandel | Intervertebral disc |
US20020032155A1 (en) | 2000-06-30 | 2002-03-14 | Ferree Bret A. | Method of treating disc herniation and disc degeneration with concentrated growth and differentiation factors |
ATE415915T1 (en) * | 2000-07-14 | 2008-12-15 | Kyphon Sarl | DEVICES FOR TREATING VERTEBRATE BODY |
DE60141653D1 (en) | 2000-07-21 | 2010-05-06 | Spineology Group Llc | A STRONG, POROUS NET BAG DEVICE AND ITS USE IN BONE SURGERY |
CN1192750C (en) | 2000-08-28 | 2005-03-16 | 迪斯科动力学公司 | Prosthesis of vertebral disc |
US20020026244A1 (en) | 2000-08-30 | 2002-02-28 | Trieu Hai H. | Intervertebral disc nucleus implants and methods |
US20050154463A1 (en) | 2000-08-30 | 2005-07-14 | Trieu Hal H. | Spinal nucleus replacement implants and methods |
AU2001285351B2 (en) | 2000-08-30 | 2004-12-02 | Warsaw Orthopedic, Inc. | Intervertebral disc nucleus implants and methods |
CA2419991C (en) | 2000-09-07 | 2011-10-04 | Sherwood Services Ag | Apparatus for and treatment of the intervertebral disc |
WO2002028417A1 (en) * | 2000-10-03 | 2002-04-11 | Collagenesis, Inc. | Methods for treating joints using viscoelastic collagen solutions |
US20020045942A1 (en) | 2000-10-16 | 2002-04-18 | Ham Michael J. | Procedure for repairing damaged discs |
AU1538702A (en) * | 2000-10-24 | 2002-05-06 | Cryolife Inc | In situ bioprosthetic filler and methods, particularly for the in situ formationof vertebral disc bioprosthetics |
ES2238500T3 (en) | 2000-10-27 | 2005-09-01 | Sdgi Holdings, Inc. | RING REPAIR SYSTEM. |
US6613044B2 (en) | 2000-10-30 | 2003-09-02 | Allen Carl | Selective delivery of cryogenic energy to intervertebral disc tissue and related methods of intradiscal hypothermia therapy |
US20040091540A1 (en) | 2000-11-15 | 2004-05-13 | Desrosiers Eric Andre | Method for restoring a damaged or degenerated intervertebral disc |
JP4202134B2 (en) | 2000-12-15 | 2008-12-24 | スパイノロジー インコーポレイテッド | Annulus reinforcement band |
US20020176893A1 (en) | 2001-02-02 | 2002-11-28 | Wironen John F. | Compositions, implants, methods, and kits for closure of lumen openings, repair of ruptured tissue, and for bulking of tissue |
US7544196B2 (en) | 2001-02-20 | 2009-06-09 | Orthovita, Inc. | System and kit for delivery of restorative materials |
US20020115742A1 (en) | 2001-02-22 | 2002-08-22 | Trieu Hai H. | Bioactive nanocomposites and methods for their use |
US6652593B2 (en) * | 2001-02-28 | 2003-11-25 | Synthes (Usa) | Demineralized bone implants |
US20040083002A1 (en) | 2001-04-06 | 2004-04-29 | Belef William Martin | Methods for treating spinal discs |
US6632235B2 (en) | 2001-04-19 | 2003-10-14 | Synthes (U.S.A.) | Inflatable device and method for reducing fractures in bone and in treating the spine |
US20030008817A1 (en) * | 2001-07-03 | 2003-01-09 | Tom Sander | Cross-link reversing agent |
US7153518B2 (en) | 2001-08-27 | 2006-12-26 | Regeneration Technologies, Inc. | Processed soft tissue for topical or internal application |
US6736815B2 (en) | 2001-09-06 | 2004-05-18 | Core Medical, Inc. | Apparatus and methods for treating spinal discs |
WO2003020327A2 (en) | 2001-09-06 | 2003-03-13 | Bone Sa | A cross-linked collagenous biomaterial |
US7004945B2 (en) | 2001-11-01 | 2006-02-28 | Spinewave, Inc. | Devices and methods for the restoration of a spinal disc |
CN100512777C (en) | 2001-12-05 | 2009-07-15 | 斯恩蒂斯有限公司 | Intervertebral disk prosthesis or nucleus replacement prosthesis |
MXPA04005707A (en) * | 2001-12-10 | 2005-06-20 | Colbar Lifescience Ltd D | Methods, devices, and preparations for intervertebral disc treatment. |
WO2003066120A1 (en) | 2002-02-04 | 2003-08-14 | Ferree Bret A | Treating degenerative disc disease through transplantation of allograft disc |
ATE362354T1 (en) | 2002-04-04 | 2007-06-15 | Synthes Gmbh | DISC PROSTHESIS OR NUCLEUS REPLACEMENT PROSTHESIS |
US20030195630A1 (en) | 2002-04-10 | 2003-10-16 | Ferree Bret A. | Disc augmentation using materials that expand in situ |
DE10223332A1 (en) | 2002-05-25 | 2003-12-04 | Efmt Entwicklungs Und Forschun | Medical implant |
AU2003240939A1 (en) | 2002-05-28 | 2003-12-12 | Virginia Commonwealth University Intellectual Property Foundation | Electroprocessed collagen and tissue engineering |
US7166133B2 (en) | 2002-06-13 | 2007-01-23 | Kensey Nash Corporation | Devices and methods for treating defects in the tissue of a living being |
ITVI20020140A1 (en) | 2002-06-26 | 2003-12-29 | Tecres Spa | DEVICE FOR THE MANUAL DOSING OF A MEDICAL FLUID, PARTICULARLY BONE CEMENT |
US20040116922A1 (en) | 2002-09-05 | 2004-06-17 | Arthrocare Corporation | Methods and apparatus for treating intervertebral discs |
US20040054413A1 (en) | 2002-09-16 | 2004-03-18 | Howmedica Osteonics Corp. | Radiovisible hydrogel intervertebral disc nucleus |
US7744651B2 (en) * | 2002-09-18 | 2010-06-29 | Warsaw Orthopedic, Inc | Compositions and methods for treating intervertebral discs with collagen-based materials |
US7887593B2 (en) | 2002-09-18 | 2011-02-15 | Warsaw Orthopedic, Inc. | Method of implanting natural tissue within the vertebral disc nucleus space using a drawstring |
US20040054414A1 (en) * | 2002-09-18 | 2004-03-18 | Trieu Hai H. | Collagen-based materials and methods for augmenting intervertebral discs |
US6932843B2 (en) | 2002-09-25 | 2005-08-23 | Medicinelodge, Inc. | Apparatus and method for the in-situ formation of a structural prosthesis |
US6827716B2 (en) | 2002-09-30 | 2004-12-07 | Depuy Spine, Inc. | Method of identifying and treating a pathologic region of an intervertebral disc |
US20040068234A1 (en) | 2002-10-03 | 2004-04-08 | Jeff Martin | Bone graft particle delivery apparatus and method |
US7135027B2 (en) | 2002-10-04 | 2006-11-14 | Baxter International, Inc. | Devices and methods for mixing and extruding medically useful compositions |
CA2735334A1 (en) | 2002-11-05 | 2004-05-21 | Spineology, Inc. | A semi-biological intervertebral disc replacement system |
KR20060079137A (en) | 2002-11-08 | 2006-07-05 | 베르트링크 코오퍼레이션. | Transpedicular intervertebral disk access methods and devices |
US20040101959A1 (en) | 2002-11-21 | 2004-05-27 | Olga Marko | Treatment of tissue with undifferentiated mesenchymal cells |
NL1022023C2 (en) | 2002-11-29 | 2004-06-03 | Dsm Nv | Artificial intervertebral disc. |
US20040186471A1 (en) | 2002-12-07 | 2004-09-23 | Sdgi Holdings, Inc. | Method and apparatus for intervertebral disc expansion |
KR20050086949A (en) | 2002-12-27 | 2005-08-30 | 안지오테크 인터내셔날 아게 | Compositions and methods of using collajolie |
JP2006515780A (en) | 2003-01-17 | 2006-06-08 | プシナーギ コーポレイション | Artificial nucleus pulposus and injection method thereof |
FR2850009B1 (en) | 2003-01-20 | 2005-12-23 | Spine Next Sa | TREATMENT ASSEMBLY FOR THE DEGENERATION OF AN INTERVERTEBRAL DISC |
CA2513055A1 (en) | 2003-01-31 | 2004-08-19 | Zimmer Orthobiologics, Inc. | Hydrogel compositions comprising nucleus pulposus tissue |
AU2004212942A1 (en) | 2003-02-14 | 2004-09-02 | Depuy Spine, Inc. | In-situ formed intervertebral fusion device |
US20040193274A1 (en) * | 2003-03-28 | 2004-09-30 | Trieu Hai H. | Materials and methods for augmenting and/or repairing intervertebral discs |
US6969405B2 (en) | 2003-04-23 | 2005-11-29 | Loubert Suddaby | Inflatable intervertebral disc replacement prosthesis |
WO2006002417A2 (en) | 2004-06-22 | 2006-01-05 | Yeung Jeffrey E | Disc shunt for treating back pain |
CA2525928A1 (en) | 2003-05-13 | 2005-01-06 | Depuy Spine, Inc. | A method of treating degenerative disc disease |
US8273347B2 (en) | 2003-05-13 | 2012-09-25 | Depuy Spine, Inc. | Autologous treatment of degenerated disc with cells |
US6958077B2 (en) | 2003-07-29 | 2005-10-25 | Loubert Suddaby | Inflatable nuclear prosthesis |
US20050100538A1 (en) | 2003-07-31 | 2005-05-12 | Attawia Mohamed | Intradiscal injection of anti-oxidants |
US8579908B2 (en) | 2003-09-26 | 2013-11-12 | DePuy Synthes Products, LLC. | Device for delivering viscous material |
US7632294B2 (en) | 2003-09-29 | 2009-12-15 | Promethean Surgical Devices, Llc | Devices and methods for spine repair |
TW200511970A (en) | 2003-09-29 | 2005-04-01 | Kwan-Ku Lin | A spine wrapping and filling apparatus |
US20050071012A1 (en) | 2003-09-30 | 2005-03-31 | Hassan Serhan | Methods and devices to replace spinal disc nucleus pulposus |
US7879102B2 (en) | 2003-09-30 | 2011-02-01 | Depuy Acromed, Inc. | Method for treatment of defects in the intervertebral disc |
CA2481663A1 (en) | 2003-10-01 | 2005-04-01 | Biomet Deutschland Gmbh | Device for the mixing and discharge of liquid and pulverulent materials for medical use |
US20050113923A1 (en) | 2003-10-03 | 2005-05-26 | David Acker | Prosthetic spinal disc nucleus |
JP4050215B2 (en) | 2003-10-20 | 2008-02-20 | ペンタックス株式会社 | Paste bone filler injector |
WO2005041813A2 (en) | 2003-10-22 | 2005-05-12 | Intrinsic Therapeutics, Inc. | Stabilized intervertebral disc barrier |
GB2407580B (en) | 2003-10-28 | 2009-02-25 | Univ Cambridge Tech | Biomaterial |
WO2005046516A2 (en) | 2003-11-10 | 2005-05-26 | Angiotech International Ag | Medical implants and anti-scarring agents |
JP2005152501A (en) | 2003-11-28 | 2005-06-16 | Kyocera Corp | Artificial nucleus pulposus and manufacturing method thereof |
US20050125066A1 (en) | 2003-12-08 | 2005-06-09 | Innovative Spinal Technologies | Nucleus replacement securing device and method |
US7763077B2 (en) | 2003-12-24 | 2010-07-27 | Biomerix Corporation | Repair of spinal annular defects and annulo-nucleoplasty regeneration |
EP1698358A4 (en) | 2003-12-26 | 2007-12-26 | Cardio Inc | Transplantable biomaterial and method of preparing the same |
JP4440939B2 (en) | 2004-01-08 | 2010-03-24 | スパイン・ウェイブ・インコーポレーテッド | Apparatus and method for injecting flowable material into distracted tissue site |
WO2005070439A1 (en) | 2004-01-09 | 2005-08-04 | Regeneration Technologies Inc. | Implant comprising a human muscle tissue matrix |
US7488322B2 (en) | 2004-02-11 | 2009-02-10 | Medtronic, Inc. | High speed surgical cutting instrument |
ATE553186T1 (en) | 2004-02-20 | 2012-04-15 | Isto Technologies Inc | DISC REPAIR AND METHOD THEREOF |
US20050187556A1 (en) | 2004-02-25 | 2005-08-25 | Synecor, Llc | Universal percutaneous spinal access system |
US8784421B2 (en) | 2004-03-03 | 2014-07-22 | Boston Scientific Scimed, Inc. | Apparatus and methods for removing vertebral bone and disc tissue |
US20050203537A1 (en) | 2004-03-09 | 2005-09-15 | Wiley Roy C. | Orthopaedic injection restrictor apparatus and method |
US8945223B2 (en) | 2004-03-12 | 2015-02-03 | Warsaw Orthopedic, Inc. | In-situ formable nucleus pulposus implant with water absorption and swelling capability |
US8029511B2 (en) | 2004-03-22 | 2011-10-04 | Disc Dynamics, Inc. | Multi-stage biomaterial injection system for spinal implants |
WO2005092248A1 (en) | 2004-03-26 | 2005-10-06 | Nuvasive Inc. | Porous implant for spinal disc nucleus replacement |
US20050222538A1 (en) | 2004-03-30 | 2005-10-06 | Sdgi Holdings, Inc. | Surgical system for delivery of viscous fluids |
WO2005096970A2 (en) | 2004-03-31 | 2005-10-20 | Advanced Biomaterial Systems, Inc. | Methods and devices for cavity creation in mammalian bone tissue |
US7282065B2 (en) | 2004-04-09 | 2007-10-16 | X-Spine Systems, Inc. | Disk augmentation system and method |
US7452351B2 (en) | 2004-04-16 | 2008-11-18 | Kyphon Sarl | Spinal diagnostic methods and apparatus |
EP2353631A3 (en) | 2004-04-23 | 2012-01-25 | Leonard Edward Forrest | Device for treatment or evacuation of intervertebral disc |
EP1591133A1 (en) | 2004-04-30 | 2005-11-02 | Synthes | Biologically active implants |
JP4722837B2 (en) | 2004-05-07 | 2011-07-13 | 生化学工業株式会社 | Nucleus pulposus filler |
ZA200610272B (en) | 2004-05-21 | 2008-07-30 | Synthes Gmbh | Replacement of nucleus pulposus using a hydrogel |
FR2870718B1 (en) | 2004-05-25 | 2006-09-22 | Spine Next Sa | TREATMENT ASSEMBLY FOR THE DEGENERATION OF AN INTERVERTEBRAL DISC |
US20050277996A1 (en) | 2004-05-28 | 2005-12-15 | Podhajsky Ronald J | Method of reducing pressure in a nucleus pulposus |
US20050273093A1 (en) | 2004-06-04 | 2005-12-08 | Scimed Life Systems, Inc. | Method of treating herniated intervertebral discs using cooled ablation |
US20060019869A1 (en) | 2004-07-23 | 2006-01-26 | Thomas Dimauro M | Intradiscal anti-inflammatory therapy involving autologous adiponectin |
JP4972288B2 (en) | 2004-08-30 | 2012-07-11 | 富士フイルム株式会社 | Image sensor |
US20060286144A1 (en) | 2005-06-17 | 2006-12-21 | Chunlin Yang | Reinforced collagen scaffold |
US7595062B2 (en) | 2005-07-28 | 2009-09-29 | Depuy Products, Inc. | Joint resurfacing orthopaedic implant and associated method |
-
2002
- 2002-09-18 US US10/245,955 patent/US20040054414A1/en not_active Abandoned
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2003
- 2003-09-16 AU AU2003267269A patent/AU2003267269B2/en not_active Ceased
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- 2003-09-16 WO PCT/US2003/029278 patent/WO2004026189A2/en active Application Filing
- 2003-11-07 US US10/704,167 patent/US20040228901A1/en not_active Abandoned
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- 2005-04-28 US US11/117,025 patent/US7713303B2/en not_active Expired - Lifetime
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US20040054414A1 (en) | 2004-03-18 |
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AU2003285198B2 (en) | 2009-04-23 |
AU2003285198A1 (en) | 2004-06-15 |
AU2003267269A1 (en) | 2004-04-08 |
AU2003267269B2 (en) | 2009-02-26 |
US20040228901A1 (en) | 2004-11-18 |
WO2004026189A2 (en) | 2004-04-01 |
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