CA2498933A1 - Method and apparatus for aligning elongated microbeads in order to interrogate the same - Google Patents

Method and apparatus for aligning elongated microbeads in order to interrogate the same Download PDF

Info

Publication number
CA2498933A1
CA2498933A1 CA002498933A CA2498933A CA2498933A1 CA 2498933 A1 CA2498933 A1 CA 2498933A1 CA 002498933 A CA002498933 A CA 002498933A CA 2498933 A CA2498933 A CA 2498933A CA 2498933 A1 CA2498933 A1 CA 2498933A1
Authority
CA
Canada
Prior art keywords
microbeads
plate
grooves
code
grating
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA002498933A
Other languages
French (fr)
Other versions
CA2498933C (en
Inventor
John Moon
Martin A. Putnam
Tuo Li
Joseph Traynor
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Illumina Inc
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US10/645,686 external-priority patent/US20040075907A1/en
Application filed by Individual filed Critical Individual
Publication of CA2498933A1 publication Critical patent/CA2498933A1/en
Application granted granted Critical
Publication of CA2498933C publication Critical patent/CA2498933C/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G03—PHOTOGRAPHY; CINEMATOGRAPHY; ANALOGOUS TECHNIQUES USING WAVES OTHER THAN OPTICAL WAVES; ELECTROGRAPHY; HOLOGRAPHY
    • G03H—HOLOGRAPHIC PROCESSES OR APPARATUS
    • G03H1/00—Holographic processes or apparatus using light, infrared or ultraviolet waves for obtaining holograms or for obtaining an image from them; Details peculiar thereto
    • G03H1/02—Details of features involved during the holographic process; Replication of holograms without interference recording
    • G03H1/0272—Substrate bearing the hologram
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502761—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip specially adapted for handling suspended solids or molecules independently from the bulk fluid flow, e.g. for trapping or sorting beads, for physically stretching molecules
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/508—Containers for the purpose of retaining a material to be analysed, e.g. test tubes rigid containers not provided for above
    • B01L3/5085—Containers for the purpose of retaining a material to be analysed, e.g. test tubes rigid containers not provided for above for multiple samples, e.g. microtitration plates
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277—Apparatus
    • B01J2219/00457—Dispensing or evacuation of the solid phase support
    • B01J2219/00459—Beads
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277—Apparatus
    • B01J2219/00457—Dispensing or evacuation of the solid phase support
    • B01J2219/00459—Beads
    • B01J2219/00461—Beads and reaction vessel together
    • B01J2219/00463—Directed sorting
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277—Apparatus
    • B01J2219/00457—Dispensing or evacuation of the solid phase support
    • B01J2219/0047—Pins
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277—Apparatus
    • B01J2219/00497—Features relating to the solid phase supports
    • B01J2219/005—Beads
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277—Apparatus
    • B01J2219/0054—Means for coding or tagging the apparatus or the reagents
    • B01J2219/00547—Bar codes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277—Apparatus
    • B01J2219/0054—Means for coding or tagging the apparatus or the reagents
    • B01J2219/00572—Chemical means
    • B01J2219/00576—Chemical means fluorophore
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/0068—Means for controlling the apparatus of the process
    • B01J2219/00702—Processes involving means for analysing and characterising the products
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/06—Fluid handling related problems
    • B01L2200/0636—Focussing flows, e.g. to laminate flows
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/06—Fluid handling related problems
    • B01L2200/0647—Handling flowable solids, e.g. microscopic beads, cells, particles
    • B01L2200/0668—Trapping microscopic beads
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/06—Auxiliary integrated devices, integrated components
    • B01L2300/0627—Sensor or part of a sensor is integrated
    • B01L2300/0654—Lenses; Optical fibres
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/04—Moving fluids with specific forces or mechanical means
    • B01L2400/0403—Moving fluids with specific forces or mechanical means specific forces
    • B01L2400/0409—Moving fluids with specific forces or mechanical means specific forces centrifugal forces
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/04—Moving fluids with specific forces or mechanical means
    • B01L2400/0403—Moving fluids with specific forces or mechanical means specific forces
    • B01L2400/0457—Moving fluids with specific forces or mechanical means specific forces passive flow or gravitation
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/04—Moving fluids with specific forces or mechanical means
    • B01L2400/0475—Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure
    • B01L2400/0487—Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure fluid pressure, pneumatics
    • G—PHYSICS
    • G03—PHOTOGRAPHY; CINEMATOGRAPHY; ANALOGOUS TECHNIQUES USING WAVES OTHER THAN OPTICAL WAVES; ELECTROGRAPHY; HOLOGRAPHY
    • G03H—HOLOGRAPHIC PROCESSES OR APPARATUS
    • G03H2210/00—Object characteristics
    • G03H2210/50—Nature of the object
    • G03H2210/53—Coded object not directly interpretable, e.g. encrypted object, barcode
    • G—PHYSICS
    • G03—PHOTOGRAPHY; CINEMATOGRAPHY; ANALOGOUS TECHNIQUES USING WAVES OTHER THAN OPTICAL WAVES; ELECTROGRAPHY; HOLOGRAPHY
    • G03H—HOLOGRAPHIC PROCESSES OR APPARATUS
    • G03H2230/00—Form or shape of the hologram when not registered to the substrate
    • G03H2230/10—Microhologram not registered to the substrate
    • G—PHYSICS
    • G03—PHOTOGRAPHY; CINEMATOGRAPHY; ANALOGOUS TECHNIQUES USING WAVES OTHER THAN OPTICAL WAVES; ELECTROGRAPHY; HOLOGRAPHY
    • G03H—HOLOGRAPHIC PROCESSES OR APPARATUS
    • G03H2270/00—Substrate bearing the hologram
    • G03H2270/20—Shape
    • G—PHYSICS
    • G03—PHOTOGRAPHY; CINEMATOGRAPHY; ANALOGOUS TECHNIQUES USING WAVES OTHER THAN OPTICAL WAVES; ELECTROGRAPHY; HOLOGRAPHY
    • G03H—HOLOGRAPHIC PROCESSES OR APPARATUS
    • G03H2270/00—Substrate bearing the hologram
    • G03H2270/20—Shape
    • G03H2270/24—Having particular size, e.g. microscopic
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/25—Chemistry: analytical and immunological testing including sample preparation

Abstract

A method and apparatus are provided for aligning optical elements or microbeads, wherein each microbead has an elongated body with a code embedded therein along a longitudinal axis thereof to be read by a code reading device.
The microbeads are aligned with a positioning device so the longitudinal axis of the microbeads is positioned in a fixed orientation relative to the code reading device. The microbeads are typically cylindrically shaped glass beads between 25 and 250 microns (~m) in diameter and between 100 and 500 ~m long, and have a holographic code embedded in the central region of the bead, which is used to identify it from the rest of the beads in a batch of beads with many different chemical probes. A cross reference is used to determine which probe is attached to which bead, thus allowing the researcher to correlate the chemical content on each bead with the measured fluorescence signal. Because the code consists of a diffraction grating typically disposed along an axis, there is a particular alignment required between the incident readout laser beam and the readout detector in two of the three rotational axes. The third axis, rotation about the center axis of the cylinder, is azimuthally symmetric and therefore does not require alignment.

Claims (63)

1. A method for aligning microbeads to be read by a code reading or other detection device, comprising the step of:
providing microbeads to a positioning device, each having an elongated body with a code embedded therein along a longitudinal axis thereof; and aligning the microbeads with the positioning device so the longitudinal axis of the microbeads is in a axed orientation relative to the code reading or other detection device.
2. A method according to claim 1, wherein the positioning device is a plate having a multiplicity of grooves therein.
3. A method according to claim 1, wherein the method includes agitating the plate to encourage the alignment of the microbeads in the grooves.
4. A method according to claim 1, wherein the microbeads are cylindrically shaped glass beads between 25 and 250 microns in diameter and between 100 and 500 microns long.
5. A method according to claim 1, wherein the microbeads have a holographic code embedded in a central region thereof.
6. A method according to claim 1, wherein the code is used to correlate a chemical content on each bead with a measured fluorescence signal.
7. A method according to claim 1, wherein each microbead is substantially aligned in relation to its pitch and yaw rotational axes.
8. A method according to claim 1, wherein the plate has a series of parallel grooves having one of several different shapes, including square, v-shaped or semi-circular.
9. A method according to claim 1, wherein the plate is an optically transparent medium including boro-silicate glass, fused silica or plastic, and the grooves are formed therein.
10. A method according to claim 1, wherein the grooves have a depth that is dimensioned to be at least the diameter of the microbeads, including at least 110% of the diameter of the microbead.
11. A method according to claim 1, wherein either the grooves have a depth between 10 and 125 microns, the depth is dimensioned within 90% of the diameter of the microbeads, or a combination thereof.
12. A method according to claim 1, wherein the spacing of the grooves is between 1 and 2 times the diameter of the microbeads.
13. A method according to claim 1, wherein the grooves have a width that is dimensioned to prevent the beads from rotating therein by more than a few degrees.
14. A method according to claim 1, wherein the grooves have a width that is dimensioned within 5% of the diameter of the microbeads.
15. A method according to claim 1, wherein the grooves have a bottom that is flat enough to prevent the heads from rotating, by more than a few tenths of a degree, relative to the code reader device.
16. A method according to claim 1, wherein the code reader device includes a readout camera.
17. A method according to claim 1, wherein the step of agitating the plate includes using a sonic transducer, a mechanical wipe, or shaking or rocking device.
18. A method according to claim 1, wherein the method includes using an open format approach by dispensing the microbeads onto the plate using a pipette tip or syringe tip and not covering the plate.
19. A method according to claim 1, wherein the method includes a closed format approach by dispensing the microbeads into a cuvette-like device having comprising the plate, at least three walls and a cover.
20. A method according to claim 19, wherein the step of dispensing includes injecting the microbeads into the cuvette-like device by placing them near an edge of an opening and allowing the surface tension, or an induced fluid flow, to pull the microbeads into the cuvette-like.
21. A method according to claim 19, wherein the method includes using a closed format approach by sectioning a closed region into two regions, a first region where the microbeads are free to move about in a plane, either in a groove or not, and a second region where the microbeads are trapped in a groove and can only move along the ages of the grooves.
22. A method according to claim 21, wherein the method includes the step of trapping the microbeads in a groove by reducing the height of the closed region so that the microbeads can no longer come out of the groove.
23. A method according to claim 21, wherein the first region is used to pre-align the beads into a groove, facilitating the introduction of beads into the second region.
24. A method according to claim 21, wherein the method includes tilting the cuvette-like up so gravity can be used to pull the microbeads along a groove from the first region to the second region.
25. A method according to claim 21, wherein the plate is made of silicon having walls formed by Su8 coupled thereto, or having walls formed by etching the silicon.
26. A method according to claim 1, wherein the method includes the step of identifying a chemical content on the surface of the microbead with a measured fluorescence signal.
27. A method according to claim 1, wherein the method includes passing a code reading signal through the microbead aligned on the poisitioning device.
28. The method according to claim 1, wherein the method further includes the step of correlating a chemical content identified on each microbead with a fluorescence signal, including one provided by an incident laser beam device.
29. A method according to claim 1, wherein the method includes the step of identifying the code in the microbead.
30. A method according to claim 1, wherein the grooves of the plate are formed using a photo lithographic process.
31. A method according to claim 1, wherein the plate includes a glass plate having Su8 thereon.
32. A method according to claim 1, wherein the glass plate is a low fluorescence glass.
33. A method according to claim 1, wherein the glass plate is a bore silicate glass.
34. A method according to claim 1, wherein the grooves on the plate are mechanically machined.
35. A method according to claim 1, wherein the grooves on the plate are formed by deep reactive. ion etching.
36. A method according to claim 1, wherein the grooves on the plate are formed by injection molding.
37. A method according to claim 2, wherein the plate has a mirror coating.
38. A method according try claim 2, wherein the plate is a disk having circumferential grooves, concentric grooves, or a combination thereof.
39. A method according to claim 2, wherein the plate is a disk, having radial grooves.
40. A method according to claim 2, wherein the plate is a disk having a microbead loading area located in the center of the disk.
41. A method according to claim 2, wherein the plate is a disk having one or more radial water channels extending from the center to the outer periphery thereof.
42. A method according to claim 2, wherein the method includes arranging the plate on a rotating disk.
43. A method according to claim 1, wherein the positioning device is a flow tube.
44. A method according to claim 43, wherein the step of providing includes providing the microbeads to the flow tube in a fluid.
45. A method according to claim 1, wherein the microbeads have tubular holes extending therethrough.
46. A method according to claim 1, wherein the microbeads have teeth or protrusions thereon.
47. Apparatus for aligning microbeads to be read by a code reading device, comprising:
a positioning device for aligning microbeads, each microbead having an elongated body with a code embedded therein along a longitudinal axis thereof, so the longitudinal axis of the microbeads is positioned in a fixed orientation relative to the code reading device.
48. Apparatus according to claim 47, wherein the positioning device is a plate having a multiplicity of grooves therein.
49. Apparatus according to claim 47, wherein the apparatus includes means for agitating the plate to encourage the alignment of the microbeads in the grooves.
50. Apparatus according to claim 47, wherein the microbeads are cylindrically shaped glass beads between 25 and 250 microns in diameter and between 100 and 500 microns long.
51. Apparatus according to claim 47, wherein the microbeads have a holographic code embedded in a central region thereof.
52. Apparatus according to claim 47, wherein the positioning device is a rotating disk having a multiplicity of circumferential grooves, concentric grooves or a combination thereof formed therein, or having one or more spiral grooves.
53. Apparatus according to claim 47, wherein the positioning device is a tube.
54. Apparatus for aligning an optical identification element, comprising:
the optical identification element having an optical substrate having at least a portion thereof with at least one diffraction grating disposed therein, the grating having at least one refractive index pitch superimposed at a common location, the grating providing an output optical signal when illuminated by an incident light signal, the optical output signal being indicative of a code, and the optical identification element being an elongated object with a longitudinal axis; and an alignment device which aligns the optical identification element such that said output optical signal is indicative of the code.
55. Apparatus according to claim 54, wherein the alignment device is a plate having a multiplicity of grooves therein.
56. Apparatus according to claim 55, wherein the plate is a disk and the multiplicity of grooves are concentric circles or a spiral.
57. Apparatus according to claim 54, wherein the alignment device is a tube having a bore for receiving the optical identification element.
58. The apparatus of claim 47 wherein said code comprises at least one diffraction grating disposed in said microbead, said grating having a resultant refractive index variation at a grating location; and said grating providing an output optical signal indicative of said code when illuminated by an incident light signal.
59. The apparatus of claim 58 wherein said resultant refractive index variation comprises at least one refractive index pitch superimposed at said grating location.
60. The apparatus of claim 59 wherein said resultant refractive index variation comprises a plurality of refractive index pitches superimposed at said grating location.
61. The method of claim 1 wherein said code comprises at least one diffraction grating disposed in said microbead, said grating having a resultant refractive index variation at a grating location; and said grating providing an output optical signal indicative of said code when illuminated by an incident light signal.
62. The method of claim 61 wherein said resultant refractive index variation comprises at least one refractive index pitch superimposed at said grating location.
63. The method of claim 62 wherein said resultant refractive index variation comprises a plurality of refractive index pitches superimposed at said grating location.
CA2498933A 2002-09-12 2003-09-12 Method and apparatus for aligning elongated microbeads in order to interrogate the same Expired - Lifetime CA2498933C (en)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US41054102P 2002-09-12 2002-09-12
US60/410,541 2002-09-12
US64568903A 2003-08-20 2003-08-20
US10/645,689 2003-08-20
US10/645,686 US20040075907A1 (en) 2002-08-20 2003-08-20 Diffraction grating-based encoded micro-particles for multiplexed experiments
US10/645,686 2003-08-20
PCT/US2003/028862 WO2004024328A1 (en) 2002-09-12 2003-09-12 Method and apparatus for aligning elongated microbeads in order to interrogate the same

Publications (2)

Publication Number Publication Date
CA2498933A1 true CA2498933A1 (en) 2004-03-25
CA2498933C CA2498933C (en) 2012-08-28

Family

ID=39959537

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2498933A Expired - Lifetime CA2498933C (en) 2002-09-12 2003-09-12 Method and apparatus for aligning elongated microbeads in order to interrogate the same

Country Status (5)

Country Link
US (1) US7399643B2 (en)
EP (1) EP1575707A1 (en)
AU (1) AU2003267192A1 (en)
CA (1) CA2498933C (en)
WO (1) WO2004024328A1 (en)

Families Citing this family (107)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7901630B2 (en) * 2002-08-20 2011-03-08 Illumina, Inc. Diffraction grating-based encoded microparticle assay stick
US7872804B2 (en) 2002-08-20 2011-01-18 Illumina, Inc. Encoded particle having a grating with variations in the refractive index
US7164533B2 (en) 2003-01-22 2007-01-16 Cyvera Corporation Hybrid random bead/chip based microarray
US7508608B2 (en) 2004-11-17 2009-03-24 Illumina, Inc. Lithographically fabricated holographic optical identification element
US7923260B2 (en) * 2002-08-20 2011-04-12 Illumina, Inc. Method of reading encoded particles
US7900836B2 (en) 2002-08-20 2011-03-08 Illumina, Inc. Optical reader system for substrates having an optically readable code
US7092160B2 (en) 2002-09-12 2006-08-15 Illumina, Inc. Method of manufacturing of diffraction grating-based optical identification element
US20100255603A9 (en) * 2002-09-12 2010-10-07 Putnam Martin A Method and apparatus for aligning microbeads in order to interrogate the same
JP4180964B2 (en) 2003-04-18 2008-11-12 日立ソフトウエアエンジニアリング株式会社 Bead array structure, manufacturing method thereof, and bead array method of capillary bead array
WO2005033681A1 (en) * 2003-10-01 2005-04-14 Cyvera Corporation Optical reader for diffraction grating-based encoded optical identification elements
US7433123B2 (en) 2004-02-19 2008-10-07 Illumina, Inc. Optical identification element having non-waveguide photosensitive substrate with diffraction grating therein
WO2005082110A2 (en) * 2004-02-26 2005-09-09 Illumina Inc. Haplotype markers for diagnosing susceptibility to immunological conditions
US7951580B2 (en) 2004-04-21 2011-05-31 The Regents Of The University Of California Automated, programmable, high throughput, multiplexed assay system for cellular and biological assays
WO2006020363A2 (en) * 2004-07-21 2006-02-23 Illumina, Inc. Method and apparatus for drug product tracking using encoded optical identification elements
JP4427411B2 (en) 2004-07-28 2010-03-10 日立ソフトウエアエンジニアリング株式会社 Bead array device and bead array method
US20080144036A1 (en) 2006-12-19 2008-06-19 Asml Netherlands B.V. Method of measurement, an inspection apparatus and a lithographic apparatus
US7791727B2 (en) 2004-08-16 2010-09-07 Asml Netherlands B.V. Method and apparatus for angular-resolved spectroscopic lithography characterization
US7695954B2 (en) 2004-10-04 2010-04-13 The Regents Of The University Of California Micropatterned plate with micro-pallets for addressable biochemical analysis
RU2007116801A (en) * 2004-10-04 2008-11-10 Дзе Риджентс Оф Дзе Юниверсити Оф Калифорния (Us) STRUCTURED MICROTABLET WITH MICROPLATES FOR ADDRESSABLE BIOCHEMICAL ANALYSIS
WO2006055736A1 (en) 2004-11-16 2006-05-26 Illumina, Inc. And methods and apparatus for reading coded microbeads
US20060134324A1 (en) * 2004-11-17 2006-06-22 Illumina, Inc. Filament with easily removed protective coating and methods for stripping the same
EP1825267A4 (en) * 2004-11-29 2008-07-09 Perkinelmer Life & Analytical Sciences Prticle-based multiplex assay for identifying glycosylation
US8232092B2 (en) 2005-08-09 2012-07-31 Maxwell Sensors, Inc. Apparatus and method for digital magnetic beads analysis
US20090201504A1 (en) * 2005-08-09 2009-08-13 Maxwell Sensors, Inc. Hydrodynamic focusing for analyzing rectangular microbeads
US7329860B2 (en) 2005-11-23 2008-02-12 Illumina, Inc. Confocal imaging methods and apparatus
US7803751B2 (en) * 2005-12-09 2010-09-28 Illumina, Inc. Compositions and methods for detecting phosphomonoester
KR100709762B1 (en) * 2005-12-22 2007-04-23 주식회사 대우일렉트로닉스 Optical multiplexer and method for manufacturing thereof, method and apparatus for recording multiplexed optical information, method and apparatus for reproducing multiplexed optical information
US20070166810A1 (en) * 2005-12-23 2007-07-19 Perkinelmer Las, Inc. Methods and compositions for detecting enzymatic activity
MX2008008079A (en) 2005-12-23 2008-10-22 Perkinelmer Las Inc Comparative genomic hybridization on encoded multiplex particles.
US20070166835A1 (en) * 2005-12-23 2007-07-19 Perkinelmer Las, Inc. Multiplex assays using magnetic and non-magnetic particles
US20100009373A1 (en) * 2005-12-23 2010-01-14 Perkinelmer Health Sciences, Inc. Methods and compositions relating to multiplex genomic gain and loss assays
US7932037B2 (en) 2007-12-05 2011-04-26 Perkinelmer Health Sciences, Inc. DNA assays using amplicon probes on encoded particles
US20090104613A1 (en) * 2005-12-23 2009-04-23 Perkinelmer Las, Inc. Methods and compositions relating to multiplexed genomic gain and loss assays
US7914988B1 (en) 2006-03-31 2011-03-29 Illumina, Inc. Gene expression profiles to predict relapse of prostate cancer
WO2007118208A2 (en) 2006-04-10 2007-10-18 The Regents Of The University Of California Systems for collection of single cells and colonies
US7830575B2 (en) 2006-04-10 2010-11-09 Illumina, Inc. Optical scanner with improved scan time
US7550271B2 (en) * 2006-04-28 2009-06-23 Perkinelmer Las, Inc. Detecting phospho-transfer activity
AU2007323920B2 (en) * 2006-11-13 2013-09-19 Perkinelmer Health Sciences, Inc. Detecting molecular interactions
US20080242560A1 (en) * 2006-11-21 2008-10-02 Gunderson Kevin L Methods for generating amplified nucleic acid arrays
US8288110B2 (en) * 2006-12-04 2012-10-16 Perkinelmer Health Sciences, Inc. Biomarkers for detecting cancer
US20080241831A1 (en) * 2007-03-28 2008-10-02 Jian-Bing Fan Methods for detecting small RNA species
US20080279874A1 (en) * 2007-05-07 2008-11-13 Wyeth Compositions and methods for modulation of plk1 kinase activity
NZ581742A (en) 2007-06-08 2012-09-28 Biogen Idec Inc Biomarkers for predicting anti-tnf responsiveness or non-responsiveness
WO2009015361A1 (en) 2007-07-25 2009-01-29 The Regents Of The University Of California Use of photosensitized epon epoxy resin 1002f for mems and biomems applications
US9487745B2 (en) 2007-07-27 2016-11-08 The Regents Of The University Of California Micro-patterned plate composed of an array of releasable elements surrounded with solid or gel walls
JP2012519871A (en) 2009-03-07 2012-08-30 ヒューレット−パッカード デベロップメント カンパニー エル．ピー． Analyzer and method for performing detection using an analyzer
US20110046009A1 (en) * 2009-08-24 2011-02-24 Perkinelmer Health Sciences, Inc. Methods for detecting dna methylation using encoded particles
EP2476108B1 (en) * 2009-09-09 2018-01-10 Absolute Software Corporation Alert for real-time risk of theft or loss
CA2774116A1 (en) 2009-09-25 2011-03-31 Signature Genomics Laboratories Llc Multiplex (+/-) stranded arrays and assays for detecting chromosomal abnormalities associated with cancer and other diseases
EP2494353B1 (en) 2009-10-30 2017-09-27 Illumina Inc. An apparatus comprising a plurality of encoded microvessels and a plurality of compartments and a method of reading a plurality of encoded micro vessels
US9759718B2 (en) 2009-11-23 2017-09-12 Cyvek, Inc. PDMS membrane-confined nucleic acid and antibody/antigen-functionalized microlength tube capture elements, and systems employing them, and methods of their use
US9700889B2 (en) 2009-11-23 2017-07-11 Cyvek, Inc. Methods and systems for manufacture of microarray assay systems, conducting microfluidic assays, and monitoring and scanning to obtain microfluidic assay results
US10022696B2 (en) 2009-11-23 2018-07-17 Cyvek, Inc. Microfluidic assay systems employing micro-particles and methods of manufacture
US9855735B2 (en) 2009-11-23 2018-01-02 Cyvek, Inc. Portable microfluidic assay devices and methods of manufacture and use
WO2011063408A1 (en) 2009-11-23 2011-05-26 Cyvek, Inc. Method and apparatus for performing assays
US9500645B2 (en) 2009-11-23 2016-11-22 Cyvek, Inc. Micro-tube particles for microfluidic assays and methods of manufacture
US10065403B2 (en) 2009-11-23 2018-09-04 Cyvek, Inc. Microfluidic assay assemblies and methods of manufacture
WO2011093939A1 (en) 2010-02-01 2011-08-04 Illumina, Inc. Focusing methods and optical systems and assemblies using the same
WO2011100503A1 (en) 2010-02-11 2011-08-18 Dana Farber Cancer Institute, Inc. Methods for predicting likelihood of responding to treatment
CN202281746U (en) * 2010-03-06 2012-06-20 伊鲁米那股份有限公司 Measuring equipment for detecting optical signal from sample as well as optical module and optical system for measuring equipment
US8951781B2 (en) 2011-01-10 2015-02-10 Illumina, Inc. Systems, methods, and apparatuses to image a sample for biological or chemical analysis
CN103649759B (en) 2011-03-22 2016-08-31 西维克公司 Microfluidic device and manufacture method and purposes
EP2718465B1 (en) 2011-06-09 2022-04-13 Illumina, Inc. Method of making an analyte array
US9566560B2 (en) 2011-10-06 2017-02-14 Illumina, Inc. Array domains having rotated patterns
US8778849B2 (en) 2011-10-28 2014-07-15 Illumina, Inc. Microarray fabrication system and method
EP2822689B1 (en) 2012-03-08 2023-07-26 Cyvek, Inc. Micro-tube particles for microfluidic assays and methods of manufacture
US9944987B2 (en) 2013-03-27 2018-04-17 Bluegnome Ltd Assessment of risk of aneuploidy
KR102122932B1 (en) * 2013-08-08 2020-06-15 삼성전기주식회사 Multi-layered ceramic capacitor and board for mounting the same
JP6666852B2 (en) 2014-01-16 2020-03-18 イルミナ インコーポレイテッド Gene expression panel for prognosis of prostate cancer recurrence
CN104035152B (en) * 2014-06-06 2016-05-25 上海大学 A kind of method of utilizing droplet ejection technology to make micro-nano grating
US9976174B2 (en) 2015-03-24 2018-05-22 Illumina Cambridge Limited Methods, carrier assemblies, and systems for imaging samples for biological or chemical analysis
CA2980807A1 (en) 2015-04-02 2016-10-06 Hmnc Value Gmbh Genetic predictors of a response to treatment with crhr1 antagonists
JP6905468B2 (en) 2015-04-02 2021-07-21 エイチエムエヌシー ダイアグノスティックス ゲーエムベーハー Methods of treatment with gene predictors of response to treatment with CRHR1 antagonists
ES2927121T3 (en) 2015-05-29 2022-11-02 Illumina Inc Sample holder and assay system for performing designated reactions
WO2017034868A1 (en) 2015-08-24 2017-03-02 Illumina, Inc. In-line pressure accumulator and flow-control system for biological or chemical assays
CN105326572B (en) * 2015-11-04 2017-08-29 庄源东 A kind of surgical laser alignment system guide device
US10228367B2 (en) 2015-12-01 2019-03-12 ProteinSimple Segmented multi-use automated assay cartridge
WO2018064116A1 (en) 2016-09-28 2018-04-05 Illumina, Inc. Methods and systems for data compression
US10695157B2 (en) 2017-01-10 2020-06-30 Musculoskeletal Transplant Foundation Packaging system for tissue grafts
USD832457S1 (en) * 2017-01-10 2018-10-30 Musculoskeletal Transplant Foundation Tissue graft retainer
US11375710B2 (en) 2017-01-10 2022-07-05 Musculoskeletal Transplant Foundation Packaging system for tissue grafts
CN110177884B (en) 2017-01-20 2021-08-06 欧姆尼欧美公司 Genotyping by polymerase binding
AU2017394644B2 (en) 2017-01-20 2020-02-06 Pacific Biosciences Of California, Inc. Allele-specific capture of nucleic acids
WO2018152162A1 (en) 2017-02-15 2018-08-23 Omniome, Inc. Distinguishing sequences by detecting polymerase dissociation
US10161003B2 (en) 2017-04-25 2018-12-25 Omniome, Inc. Methods and apparatus that increase sequencing-by-binding efficiency
WO2019046288A1 (en) 2017-08-31 2019-03-07 Massachusetts Institute Of Technology Compositions and multiplex assays for characterizing active proteases and their inhibitors
USD864414S1 (en) 2017-10-03 2019-10-22 Musculoskeletal Transplant Foundation Tissue graft retainer
US10582994B2 (en) 2018-03-06 2020-03-10 Musculoskeletal Transplant Foundation Implant packaging assembly
WO2019209426A1 (en) 2018-04-26 2019-10-31 Omniome, Inc. Methods and compositions for stabilizing nucleic acid-nucleotide-polymerase complexes
US11339428B2 (en) 2018-05-31 2022-05-24 Pacific Biosciences Of California, Inc. Increased signal to noise in nucleic acid sequencing
CA3107165A1 (en) 2018-07-24 2020-01-30 Omniome, Inc. Serial formation of ternary complex species
EP3853358A1 (en) 2018-09-17 2021-07-28 Omniome, Inc. Engineered polymerases for improved sequencing
CN113166805A (en) 2018-12-04 2021-07-23 欧姆尼欧美公司 Mixed phase fluids for nucleic acid sequencing and other analytical assays
EP3924513B1 (en) 2019-02-14 2023-04-12 Pacific Biosciences of California, Inc. Mitigating adverse impacts of detection systems on nucleic acids and other biological analytes
US11377655B2 (en) 2019-07-16 2022-07-05 Pacific Biosciences Of California, Inc. Synthetic nucleic acids having non-natural structures
TW202124406A (en) 2019-09-10 2021-07-01 美商歐姆尼歐美公司 Reversible modification of nucleotides
EP4045683A1 (en) 2019-10-18 2022-08-24 Omniome, Inc. Methods and compositions for capping nucleic acids
US20210139867A1 (en) 2019-11-08 2021-05-13 Omniome, Inc. Engineered polymerases for improved sequencing by binding
CN115243792A (en) 2020-02-04 2022-10-25 加利福尼亚太平洋生物科学股份有限公司 Flow cell and methods of making and using the same
EP4114966A1 (en) 2020-03-03 2023-01-11 Pacific Biosciences Of California, Inc. Methods and compositions for sequencing double stranded nucleic acids
EP4004547B1 (en) 2020-04-14 2023-10-11 (INSERM) Institut National de la Santé et de la Recherche Médicale Methods for detecting the presence of coronavirus-specific antibodies in a subject
EP4146822A1 (en) 2020-05-05 2023-03-15 Pacific Biosciences of California, Inc. Compositions and methods for modifying polymerase-nucleic acid complexes
USD954993S1 (en) 2020-06-17 2022-06-14 Musculoskeletal Transplant Foundation Tissue graft retainer
WO2022043415A1 (en) 2020-08-27 2022-03-03 INSERM (Institut National de la Santé et de la Recherche Médicale) Methods for detecting the presence of pemphigus-specific autoantibodies in a sample
WO2023122363A1 (en) 2021-12-23 2023-06-29 Illumina Software, Inc. Dynamic graphical status summaries for nucelotide sequencing
US20230215515A1 (en) 2021-12-23 2023-07-06 Illumina Software, Inc. Facilitating secure execution of external workflows for genomic sequencing diagnostics
WO2023129764A1 (en) 2021-12-29 2023-07-06 Illumina Software, Inc. Automatically switching variant analysis model versions for genomic analysis applications

Family Cites Families (173)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3916182A (en) 1972-08-21 1975-10-28 Western Electric Co Periodic dielectric waveguide filter
FR2197495A5 (en) 1972-08-25 1974-03-22 Thomson Csf
US3891302A (en) 1973-09-28 1975-06-24 Western Electric Co Method of filtering modes in optical waveguides
US4011435A (en) 1974-02-01 1977-03-08 Ncr Corporation Optical indicia marking and detection system
US3968476A (en) 1974-07-17 1976-07-06 Sperry Rand Corporation Spurious signal removal in optical processor fingerprint identification apparatus
SE388694B (en) 1975-01-27 1976-10-11 Kabi Ab WAY TO PROVIDE AN ANTIGEN EXV IN SAMPLES OF BODY WHEATS, USING POROST BERAR MATERIAL BONDED OR ADSORBING ANTIBODIES
US4053433A (en) * 1975-02-19 1977-10-11 Minnesota Mining And Manufacturing Company Method of tagging with color-coded microparticles
US4023010A (en) 1975-09-08 1977-05-10 Ncr Corporation Optical identification system and reader for reading optical gratings on a record medium
US4053228A (en) 1975-12-12 1977-10-11 Michael Schiller Finger identification
DE2648180C2 (en) 1976-02-18 1978-09-07 Hoechst Ag, 6000 Frankfurt Device for checking the authenticity of an identity carrier
US4301139A (en) 1979-06-21 1981-11-17 Ames-Yissum Ltd. Multilayer column chromatography specific binding assay method, test device and test kit
DE3009404A1 (en) 1980-03-12 1981-09-17 Philips Patentverwaltung Gmbh, 2000 Hamburg DEVICE FOR ADJUSTING A MOVABLE ELECTROACUTIC SOUND TRANSDUCER
DE3069558D1 (en) 1980-08-21 1984-12-06 Ibm Identification card comprising information in holographic form
US4386274A (en) 1980-11-10 1983-05-31 Saul Altshuler Isotope separation by standing waves
EP0057271B1 (en) 1981-02-03 1984-10-10 LGZ LANDIS & GYR ZUG AG Method for preventing the sucessful forgery of documents and device therefor
US4447546A (en) 1982-08-23 1984-05-08 Myron J. Block Fluorescent immunoassay employing optical fiber in capillary tube
CA1237645A (en) 1982-12-21 1988-06-07 John H. Fisher Assay technique
US4937048A (en) 1983-01-31 1990-06-26 Olympus Optical Company Limited Carrier transporting apparatus and carrier container for use in an immunological analysis
GB8314523D0 (en) 1983-05-25 1983-06-29 Lowe C R Diagnostic device
DE3484505D1 (en) 1983-12-19 1991-05-29 Daiichi Pure Chemicals Co Ltd IMMUNTEST.
US4560881A (en) 1984-03-13 1985-12-24 Syntex (U.S.A.) Inc. Method and apparatus for enhanced detection of electromagnetic signals
NZ211888A (en) * 1984-05-10 1987-08-31 Abbott Lab Biotin-antibiotin immunoassay for detecting ligands
US4647544A (en) 1984-06-25 1987-03-03 Nicoli David F Immunoassay using optical interference detection
USRE33581E (en) 1984-06-25 1991-04-30 Immunoassay using optical interference detection
JP2521708B2 (en) 1984-08-13 1996-08-07 ユナイテッド テクノロジーズ コーポレーション Method of forming a grating in an optical fiber
GB8423204D0 (en) 1984-09-14 1984-10-17 Comtech Res Unit Assay technique and equipment
US4740468A (en) 1985-02-14 1988-04-26 Syntex (U.S.A.) Inc. Concentrating immunochemical test device and method
GB8509492D0 (en) 1985-04-12 1985-05-15 Plessey Co Plc Optical assay
US4701754A (en) * 1985-04-18 1987-10-20 Fmc Corporation Indicator device for substance receiving wells in a microtiter plate
US4685480A (en) 1985-08-30 1987-08-11 Abbott Laboratories Combined washer and aspirator
US4716121A (en) 1985-09-09 1987-12-29 Ord, Inc. Fluorescent assays, including immunoassays, with feature of flowing sample
US4748110A (en) 1985-09-25 1988-05-31 Abbott Laboratories Immunoassay for HTLV-III antigens
US4678752A (en) 1985-11-18 1987-07-07 Becton, Dickinson And Company Automatic random access analyzer
US4958376A (en) 1985-12-27 1990-09-18 Grumman Aerospace Corporation Robotic vision, optical correlation system
US5160701A (en) 1986-02-18 1992-11-03 Abbott Laboratories Solid-phase analytical device and method for using same
US4740688A (en) 1986-03-20 1988-04-26 Smiths Industries Public Limited Company Optical transducers with wavelength coding
GB8607975D0 (en) * 1986-04-01 1986-05-08 Fisons Plc Devices
GB8612221D0 (en) 1986-05-20 1986-06-25 Amersham Int Plc Assaying species in sample
US5143853A (en) 1986-06-25 1992-09-01 Trustees Of Tufts College Absorbance modulated fluorescence detection methods and sensors
US4822746A (en) 1986-06-25 1989-04-18 Trustees Of Tufts College Radiative and non-radiative energy transfer and absorbance modulated fluorescence detection methods and sensors
US5114864A (en) 1986-06-25 1992-05-19 Trustees Of Tufts College Fiber optic sensors, apparatus, and detection methods using fluid erodible controlled release polymers for delivery of reagent formulations
GB8618133D0 (en) 1986-07-24 1986-09-03 Pa Consulting Services Biosensors
US5030558A (en) 1986-11-07 1991-07-09 Syntex (U.S.A.) Inc. Qualitative immunochromatographic method and device
US5141848A (en) 1987-01-21 1992-08-25 Abbott Laboratories Confirmatory immunoassay using microparticle separation
GB8705649D0 (en) 1987-03-10 1987-04-15 Pa Consulting Services Assay sensor
GB8713649D0 (en) 1987-06-11 1987-07-15 Pa Consulting Services Biological assay
SE458968B (en) 1987-06-16 1989-05-22 Wallac Oy BIOSPECIFIC ANALYTICAL PROCEDURE FOR MULTIPLE ANALYTICS WHICH DO NOT INCLUDE PARTICULAR COATING AND LABELING WITH FLUORESCING LABEL SUBSTANCES
US4921805A (en) 1987-07-29 1990-05-01 Life Technologies, Inc. Nucleic acid capture method
AU604364B2 (en) 1987-08-13 1990-12-13 Dow Chemical Company, The Sulfur dioxide removal from gas streams using hydroxyalkyl substituted piperazinones
US4816659A (en) 1987-10-13 1989-03-28 Control Module Inc. Bar code reader head
US4841140A (en) 1987-11-09 1989-06-20 Honeywell Inc. Real-time color comparator
DE3905481C2 (en) 1988-02-23 2003-01-09 Sony Corp Method and device for optical data traffic
GB8807486D0 (en) 1988-03-29 1988-05-05 Ares Serono Res & Dev Ltd Waveguide sensor
US5002867A (en) 1988-04-25 1991-03-26 Macevicz Stephen C Nucleic acid sequence determination by multiple mixed oligonucleotide probes
US5166813A (en) 1988-05-31 1992-11-24 Nygene Corporation Optical evaluation using a hologram barrier filter
US5089387A (en) 1988-07-07 1992-02-18 Adeza Biomedical Corporation Dna probe diffraction assay and reagents
US5033826A (en) 1989-03-27 1991-07-23 Hewlett-Packard Company High temporal resolution optical instrument
US5800992A (en) * 1989-06-07 1998-09-01 Fodor; Stephen P.A. Method of detecting nucleic acids
US5003600A (en) 1989-08-03 1991-03-26 The United States Of America As Represented By The Department Of Energy Diffraction gratings used as identifying markers
US5200794A (en) 1989-08-11 1993-04-06 Nhk Spring Co., Ltd. Optical head for an optical authenticity identifing system
US5442433A (en) 1989-08-11 1995-08-15 Nhk Spring Co., Ltd. Identification system for an article having individually attached patches
US5291006A (en) 1989-08-11 1994-03-01 Nhk Spring Co., Ltd. Authenticity identifying system for information storage cards
US5095194A (en) 1989-10-12 1992-03-10 Joseph Barbanell Holographic credit card with automatical authentication and verification
US5065008A (en) 1989-10-18 1991-11-12 Fuji Photo Film Co., Ltd. Scanning microscope and scanning mechanism for the same
US5115121A (en) 1990-01-05 1992-05-19 Control Module Inc. Variable-sweep bar code reader
US5090807A (en) 1990-01-10 1992-02-25 Environmental Research Institute Of Michigan Real time optical pre-detection processing of multispectral image data
US5138468A (en) 1990-02-02 1992-08-11 Dz Company Keyless holographic lock
JPH0834003B2 (en) 1990-03-08 1996-03-29 直弘 丹野 Optical waveguide storage medium and optical reproducing device
EP0455067B1 (en) 1990-05-03 2003-02-26 F. Hoffmann-La Roche Ag Micro-optical sensor
US5067155A (en) 1990-05-09 1991-11-19 Control Module Inc. Method and means to limit access to computer systems
ATE167523T1 (en) 1990-05-11 1998-07-15 Microprobe Corp IMMERSIBLE TEST STRIPS FOR NUCLEIC ACID HYBRIDIZATION ASSAY AND METHOD FOR COVALENT IMMOBILIZATION OF OLIGONUCLEOTIDES
GB9014263D0 (en) 1990-06-27 1990-08-15 Dixon Arthur E Apparatus and method for spatially- and spectrally- resolvedmeasurements
US5129974A (en) 1990-08-23 1992-07-14 Colorcode Unlimited Corporation Microlabelling system and method of making thin labels
US5239178A (en) 1990-11-10 1993-08-24 Carl Zeiss Optical device with an illuminating grid and detector grid arranged confocally to an object
US5105305A (en) 1991-01-10 1992-04-14 At&T Bell Laboratories Near-field scanning optical microscope using a fluorescent probe
US5244636A (en) 1991-01-25 1993-09-14 Trustees Of Tufts College Imaging fiber optic array sensors, apparatus, and methods for concurrently detecting multiple analytes of interest in a fluid sample
US5104209A (en) 1991-02-19 1992-04-14 Her Majesty The Queen In Right Of Canada, As Represented By The Minister Of Communications Method of creating an index grating in an optical fiber and a mode converter using the index grating
US5367588A (en) 1992-10-29 1994-11-22 Her Majesty The Queen In Right Of Canada, As Represented By The Minister Of Communications Method of fabricating Bragg gratings using a silica glass phase grating mask and mask used by same
DE4111903A1 (en) 1991-04-12 1992-10-15 Bayer Ag SPECTROSCOPY-CORRECTED LIGHT-SCREEN MICROSCOPY
JP2769393B2 (en) 1991-04-26 1998-06-25 直弘 丹野 3D optical recording device
US5196350A (en) 1991-05-29 1993-03-23 Omnigene, Inc. Ligand assay using interference modulation
US5144461A (en) 1991-06-20 1992-09-01 Horan Philip R Portable holographic recording apparatus
WO1993005478A1 (en) * 1991-08-28 1993-03-18 Becton, Dickinson & Company Gravitational attractor engine for adaptively autoclustering n-dimensional data streams
JP2561186B2 (en) 1991-09-11 1996-12-04 日本発条株式会社 Object identification structure
US5349442A (en) 1991-09-20 1994-09-20 Eg&G Idaho, Inc. Hand held phase-shifting diffraction moire interferometer
AU3232793A (en) 1991-12-19 1993-07-19 Control Module Inc. Secure optomagnetic identification
US5742432A (en) * 1991-12-19 1998-04-21 Bianco; James S. Apparatus for manufacture of diffraction gratings for identification means
US5465176A (en) 1991-12-19 1995-11-07 Control Module Inc. Method of embossing repeating patterns on a substrate, the patterns having different rates of repetition
US5432329A (en) 1992-02-07 1995-07-11 American Bank Note Holographics Automated holographic optical recognition and decoding system for verification
US5374818A (en) 1992-03-09 1994-12-20 Control Module Inc. Identification means with integral memory device
US5376313A (en) 1992-03-27 1994-12-27 Abbott Laboratories Injection molding a plastic assay cuvette having low birefringence
WO2004099881A1 (en) * 1992-04-24 2004-11-18 Keishi Saitoh Photoreceptor member
AU666382B2 (en) 1992-05-01 1996-02-08 Nippon Telegraph & Telephone Corporation Method for identifying optical line
US5291027A (en) 1992-07-08 1994-03-01 Toppan Printing Co., Ltd. Optical identification multiple diffraction grating mark member and card using the same
US5372783A (en) 1992-08-03 1994-12-13 Sapidyne, Inc. Assay system
US5342790A (en) 1992-10-30 1994-08-30 Becton Dickinson And Company Apparatus for indirect fluorescent assay of blood samples
EP0609812B1 (en) 1993-02-01 1998-01-07 Matsushita Electric Industrial Co., Ltd. Waveguide-type image transmission device and fingerprint identification device
US5364797A (en) 1993-05-20 1994-11-15 Mobil Oil Corp. Sensor device containing mesoporous crystalline material
US20020197456A1 (en) * 1993-06-30 2002-12-26 Pope Edward J. A. Integrated electro-luminescent biochip
DE69422246T2 (en) * 1993-08-31 2000-05-11 Control Module Inc Secure optical identification process and the necessary means
US5426297A (en) 1993-09-27 1995-06-20 United Technologies Corporation Multiplexed Bragg grating sensors
US5352582A (en) 1993-10-28 1994-10-04 Hewlett-Packard Company Holographic based bio-assay
US5610287A (en) * 1993-12-06 1997-03-11 Molecular Tool, Inc. Method for immobilizing nucleic acid molecules
US5388173A (en) 1993-12-20 1995-02-07 United Technologies Corporation Method and apparatus for forming aperiodic gratings in optical fibers
JPH07210071A (en) * 1994-01-25 1995-08-11 Nhk Spring Co Ltd Discrimination system for object
US5461475A (en) 1994-02-02 1995-10-24 Physical Optics Corporation Binary optical spectrum analyzer
US5468649A (en) 1994-02-15 1995-11-21 Abbott Laboratories Process for labeling acridinium to microparticles and application in an instrument
US5682244A (en) * 1994-03-25 1997-10-28 Barlow; Clyde H. Automated optical detection of tissue perfusion by microspheres
US5607188A (en) * 1994-06-24 1997-03-04 Imation Corp. Marking of optical disc for customized identification
US5712912A (en) * 1995-07-28 1998-01-27 Mytec Technologies Inc. Method and apparatus for securely handling a personal identification number or cryptographic key using biometric techniques
US5528045A (en) 1995-04-06 1996-06-18 Becton Dickinson And Company Particle analyzer with spatially split wavelength filter
US6352854B1 (en) * 1995-04-25 2002-03-05 Discovery Partners International, Inc. Remotely programmable matrices with memories
US5874214A (en) * 1995-04-25 1999-02-23 Irori Remotely programmable matrices with memories
US6025129A (en) * 1995-04-25 2000-02-15 Irori Remotely programmable matrices with memories and uses thereof
US6340588B1 (en) * 1995-04-25 2002-01-22 Discovery Partners International, Inc. Matrices with memories
US6017754A (en) * 1995-08-24 2000-01-25 Invitrogen Corporation System for isolating and identifying eukaryotic cells transfected with genes and vectors, host cells and methods thereof
US5633724A (en) * 1995-08-29 1997-05-27 Hewlett-Packard Company Evanescent scanning of biochemical array
AU7398996A (en) * 1995-10-11 1997-04-30 Luminex Corporation Multiplexed analysis of clinical specimens apparatus and method
US5736330A (en) * 1995-10-11 1998-04-07 Luminex Corporation Method and compositions for flow cytometric determination of DNA sequences
AU713820B2 (en) * 1995-10-16 1999-12-09 Sumitomo Electric Industries, Ltd. Optical fiber diffraction grating, a method of fabricating thereof and a laser light source
US5633975A (en) * 1995-11-14 1997-05-27 The United States Of America As Represented By The Administrator Of The National Aeronautics And Space Administration Security system responsive to optical fiber having Bragg grating
AU1102197A (en) * 1995-12-05 1997-06-27 Sherbrooke Securities Limited Charge card
NL1001876C2 (en) * 1995-12-12 1997-06-17 Ing Groep Nv Method for affixing a security badge to an object, such as a bank card, credit card, ID or part of an engine or machine.
US5729365A (en) * 1996-01-11 1998-03-17 Sandia Corporation Computer generated holographic microtags
GB9602542D0 (en) * 1996-02-08 1996-04-10 Fisons Plc Analytical device
US6355198B1 (en) * 1996-03-15 2002-03-12 President And Fellows Of Harvard College Method of forming articles including waveguides via capillary micromolding and microtransfer molding
US5721435A (en) * 1996-04-09 1998-02-24 Hewlett Packard Company Methods and apparatus for measuring optical properties of biological and chemical substances
DE69737513T2 (en) * 1996-04-25 2007-12-13 Genicon Sciences Corp., San Diego PARTICULAR LABEL USING ANALYTASSAY
AU3596597A (en) * 1996-07-08 1998-02-02 Animas Corporation Implantable sensor and system for in vivo measurement and control of fluid constituent levels
US5874187A (en) * 1996-08-15 1999-02-23 Lucent Technologies Incorporated Photo recording medium
US6027694A (en) * 1996-10-17 2000-02-22 Texperts, Inc. Spillproof microplate assembly
GB9703078D0 (en) * 1997-02-14 1997-04-02 Univ Southampton Optical fibre and optical fibre device
DE19707227A1 (en) * 1997-02-24 1998-08-27 Bodenseewerk Perkin Elmer Co Light scanner
JP3356784B2 (en) * 1997-02-28 2002-12-16 バースタイン テクノロジーズ，インコーポレイティド Optical disc and method for performing optical analysis of a sample
US6692912B1 (en) * 1997-03-05 2004-02-17 Matrix Technologies Corporation Nucleic acid-containing polymerizable complex
US6542673B1 (en) * 1997-03-13 2003-04-01 Cirrex Corp. Identifier system and components for optical assemblies
US6046925A (en) * 1997-04-14 2000-04-04 The Regents Of The University Of California Photochromic fluorescent proteins and optical memory storage devices based on fluorescent proteins
CH693517A5 (en) * 1997-06-06 2003-09-15 Ovd Kinegram Ag Surface pattern.
US6096496A (en) * 1997-06-19 2000-08-01 Frankel; Robert D. Supports incorporating vertical cavity emitting lasers and tracking apparatus for use in combinatorial synthesis
US6174648B1 (en) * 1997-07-08 2001-01-16 Oki Electric Industry Co., Ltd. Optical filter fabrication method using fiber holder with spiral groove and phase mask with spiral diffraction grating
US6043880A (en) * 1997-09-15 2000-03-28 Becton Dickinson And Company Automated optical reader for nucleic acid assays
WO1999022262A1 (en) * 1997-10-29 1999-05-06 Macaulay Calum E Apparatus and methods relating to spatially light modulated microscopy
US6060256A (en) * 1997-12-16 2000-05-09 Kimberly-Clark Worldwide, Inc. Optical diffraction biosensor
JPH11235536A (en) * 1998-02-23 1999-08-31 Takeda Chem Ind Ltd Bead separator
US6560017B1 (en) * 1998-03-02 2003-05-06 James S. Bianco Compound secure optical identification method and means
US6035082A (en) * 1998-03-16 2000-03-07 Luna Innovations, Inc. Process for preparing an optical fiber sensor with enhanced sensitivity
US6242056B1 (en) * 1998-05-08 2001-06-05 Innovative Concepts Unlimited, Llc Process for applying light-emission-enhancement microbead paint compositions
GB9811655D0 (en) * 1998-05-29 1998-07-29 Univ Cambridge Tech Methods and materials for producing holographic sensors
US5907407A (en) * 1998-08-10 1999-05-25 Innovative Lasers Corporation ILS sensors for alcohol detection within vehicles
GB9820163D0 (en) * 1998-09-17 1998-11-11 Sentec Ltd Micro-fabricated coded labels, reading systems and their applications
US6221579B1 (en) * 1998-12-11 2001-04-24 Kimberly-Clark Worldwide, Inc. Patterned binding of functionalized microspheres for optical diffraction-based biosensors
US6194563B1 (en) * 1999-03-26 2001-02-27 Vysis, Inc. Solid phase nucleic acid labeling by transamination
JP3746658B2 (en) * 1999-04-12 2006-02-15 株式会社日立製作所 Method and apparatus for producing probe array using fine particles
US6908737B2 (en) * 1999-04-15 2005-06-21 Vitra Bioscience, Inc. Systems and methods of conducting multiplexed experiments
US6371370B2 (en) * 1999-05-24 2002-04-16 Agilent Technologies, Inc. Apparatus and method for scanning a surface
US6356681B1 (en) * 1999-07-09 2002-03-12 Corning Incorporated Method and apparatus for trimming the optical path length of optical fiber components
ATE359502T1 (en) * 1999-07-16 2007-05-15 Applera Corp APPARATUS AND METHOD FOR HIGH DENSITY ELECTROPHORESIS
US6383754B1 (en) * 1999-08-13 2002-05-07 Yale University Binary encoded sequence tags
US6874639B2 (en) * 1999-08-23 2005-04-05 Spectra Systems Corporation Methods and apparatus employing multi-spectral imaging for the remote identification and sorting of objects
US20020006664A1 (en) * 1999-09-17 2002-01-17 Sabatini David M. Arrayed transfection method and uses related thereto
CA2403708A1 (en) * 2000-03-22 2001-09-27 Quantum Dot Corporation Methods of using semiconductor nanocrystals in bead-based nucleic acid assays
US6759235B2 (en) * 2000-04-06 2004-07-06 Quantum Dot Corporation Two-dimensional spectral imaging system
US6533183B2 (en) * 2000-05-03 2003-03-18 Novo Nordisk A/S Coding of cartridges for an injection device
US6515753B2 (en) * 2000-05-19 2003-02-04 Aclara Biosciences, Inc. Optical alignment in capillary detection using capillary wall scatter
US20030153006A1 (en) * 2000-05-22 2003-08-14 Masao Washizu Novel method for forming polymer pattern
EP1284992A2 (en) * 2000-05-30 2003-02-26 Viridis Biotech Inc. Polyubiquitin based hydrogel and uses thereof
US6481364B2 (en) * 2000-07-21 2002-11-19 James Woyjeck Anchoring device and methods of use
US6545758B1 (en) * 2000-08-17 2003-04-08 Perry Sandstrom Microarray detector and synthesizer
US20030082568A1 (en) * 2000-11-27 2003-05-01 Phan Brigitte Chau Use of restriction enzymes and other chemical methods to decrease non-specific binding in dual bead assays and related bio-discs, methods, and system apparatus for detecting medical targets
US6522406B1 (en) * 2001-04-20 2003-02-18 Nanometrics Incorporated Correcting the system polarization sensitivity of a metrology tool having a rotatable polarizer
EP1430335B1 (en) * 2001-08-27 2017-01-11 Steyphi Services DE LLC Amplitude and phase control in distributed optical structures
US7335153B2 (en) * 2001-12-28 2008-02-26 Bio Array Solutions Ltd. Arrays of microparticles and methods of preparation thereof
WO2003067231A1 (en) * 2002-02-07 2003-08-14 The Regents Of The University Of California Optically encoded particles

Also Published As

Publication number Publication date
US20040132205A1 (en) 2004-07-08
WO2004024328B1 (en) 2004-06-03
US7399643B2 (en) 2008-07-15
AU2003267192A1 (en) 2004-04-30
CA2498933C (en) 2012-08-28
WO2004024328A1 (en) 2004-03-25
EP1575707A1 (en) 2005-09-21

Similar Documents

Publication Publication Date Title
CA2498933A1 (en) Method and apparatus for aligning elongated microbeads in order to interrogate the same
US7175980B2 (en) Method of making a plastic colorimetric resonant biosensor device with liquid handling capabilities
US7901630B2 (en) Diffraction grating-based encoded microparticle assay stick
US8877129B2 (en) Method and device for optical detection of substances in a liquid or gaseous medium
US7101660B2 (en) Method for producing a colorimetric resonant reflection biosensor on rigid surfaces
US20060160208A1 (en) Multi-well plate with alignment grooves for encoded microparticles
CA2538801A1 (en) Improved method and apparatus for aligning microbeads in order to interrogate the same
US7306827B2 (en) Method and machine for replicating holographic gratings on a substrate
US9268983B2 (en) Optical system and method for reading encoded microbeads
US7879598B2 (en) Multianalyte determination system and methods
US7233391B2 (en) Optical device integrated with well
US7799558B1 (en) Ligand binding assays on microarrays in closed multiwell plates
US6534011B1 (en) Device for detecting biochemical or chemical substances by fluorescence excitation
US7271885B2 (en) Plasmon resonance measuring method and apparatus
US20060286663A1 (en) Method for producing a colorimetric resonant reflection biosensor on rigid surfaces
US20040126875A1 (en) Assay stick
US8062900B2 (en) Optically readable microplate
WO2005079544A3 (en) Multi-well plate with alignment grooves for encoded microparticles
JP2005505441A (en) Microfabricated lens, its manufacturing method and application
CA2373537A1 (en) Multiplexed fluorescent detection in microfluidic devices
CN1898548B (en) Disposable reaction vessel with integrated optical elements
CN104220862A (en) Target substance capturing device
US7863037B1 (en) Ligand binding assays on microarrays in closed multiwell plates
EP1190235B1 (en) Imaging assay analysis for microsamples
WO2023100203A1 (en) Optical sensor, support for said optical sensor and detection system to detect the presence and/or concentration of an analyte in a solution

Legal Events

Date Code Title Description
EEER Examination request
MKEX Expiry

Effective date: 20230912