CA2497154A1 - Substance delivery via a rotating microabrading surface - Google Patents

Substance delivery via a rotating microabrading surface Download PDF

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Publication number
CA2497154A1
CA2497154A1 CA002497154A CA2497154A CA2497154A1 CA 2497154 A1 CA2497154 A1 CA 2497154A1 CA 002497154 A CA002497154 A CA 002497154A CA 2497154 A CA2497154 A CA 2497154A CA 2497154 A1 CA2497154 A1 CA 2497154A1
Authority
CA
Canada
Prior art keywords
housing
microabrader
abrader
array
skin
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA002497154A
Other languages
French (fr)
Other versions
CA2497154C (en
Inventor
M. Ishaq Haider
Alexander G. Lastovich
Timothy J. Erskine
John A. Mikszta
Frank E. Martin
Scott A. O'connor
Jason B. Alarcon
John P. Dekker, Iii
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Becton Dickinson and Co
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2497154A1 publication Critical patent/CA2497154A1/en
Application granted granted Critical
Publication of CA2497154C publication Critical patent/CA2497154C/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/20—Surgical instruments, devices or methods, e.g. tourniquets for vaccinating or cleaning the skin previous to the vaccination
    • A61B17/205—Vaccinating by means of needles or other puncturing devices
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M31/00—Devices for introducing or retaining media, e.g. remedies, in cavities of the body
    • A61M31/002—Devices for releasing a drug at a continuous and controlled rate for a prolonged period of time
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/32—Surgical cutting instruments
    • A61B2017/320004—Surgical cutting instruments abrasive
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M2037/0007—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin having means for enhancing the permeation of substances through the epidermis, e.g. using suction or depression, electric or magnetic fields, sound waves or chemical agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
    • A61M2037/0023—Drug applicators using microneedles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
    • A61M2037/0038—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles having a channel at the side surface
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
    • A61M2037/0046—Solid microneedles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
    • A61M2037/0053—Methods for producing microneedles

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Anesthesiology (AREA)
  • Hematology (AREA)
  • Medical Informatics (AREA)
  • Dermatology (AREA)
  • Surgery (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Media Introduction/Drainage Providing Device (AREA)
  • Surgical Instruments (AREA)
  • Medicinal Preparation (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Infusion, Injection, And Reservoir Apparatuses (AREA)

Abstract

A method and device for the delivery of a substance into skin via the rotational movement of a microabrader device reduces the effects of operator variability. The method includes applying a substance to an area of a patient's skin through the rotational movement of microprotrusions. The movement of the microprotrusions can be imparted by a spring device or the like present in the microabrader device or the motion of the operator through the handle of the microabrader device. The rotational motion localizes the administration of the drug or vaccine dosage in the abraded skin area. The device can include means for monitoring pressure of the device against the skin and thereby promote consistency between applications and control of penetration depth. The substance, drug or vaccine may be placed on the microprotrusions and a reconstituting liquid included in the microabrader device.

Claims (10)

1. A rotary abrader device comprising:
a housing comprising at least one housing element, wherein said at least one housing element is selected from the group consisting of an upper housing, a lower housing, an internal housing, an external housing, and combinations thereof;
at least one housing element adapted to rotate;
at least one array of microprotrusions adapted to disrupt the skin of a subject when rotated;
a mechanical rotating means for mechanically rotating said at least one array of microprotrusions against the skin of a subject with sufficient force to disrupt and substantially penetrate the stratum corneum of the subject without piercing said stratum corneum.
2. The rotary abrader device of claim 1, further comprising at least one substance delivery port adapted for applying a substance to the skin of said subject at a delivery site prior to or simultaneously with the mechanical rotation of said array at said delivery site.
3. The rotary abrader device of claim 2, wherein the housing further comprises at least one stationary element.

3. The rotary abrading device of claim 3, wherein the at least one element adapted to rotate is further adapted for manual rotation.
4. The rotary abrader device of claim 1, further comprising:
an interlock mechanism disposed within said abrader housing for holding said microabrader array stationary until deactivated
5. The rotary device according to claim 4, wherein said interlock mechanism comprises:

a button protruding through the abrader housing, said button being coupled to a longitudinally moveable rod; and a spring within said abrader housing and surrounding said longitudinally moveable rod, wherein said microabrader array is coupled to an end of said longitudinally moveable rod so that said spring holds said microabrader array stationary until said button is depressed thereby deactivating said interlock mechanism.
6. The rotary device according to claim 5, further comprising a freely rotatable sleeve mounted within said abrader housing, said sleeve having an end face to which said microabrader array is attached and having threads with which the end of said longitudinally moveable rod connects so that a force applied to said button causes said longitudinally moveable rod to move along the threads of said sleeve thereby rotating said microabrader array.
7. The rotary device according to claim 4, further comprising means for retracting said microabrader array inside said abrader housing.
8. A method for delivering substance into skin via a microabrader device comprising the steps of:
positioning a microabrader device at a delivery site on the skin of a subject, said microabrader device comprising an abrader housing that surrounds an array of microprotrusions, wherein the abrader housing comprises at least one housing element selected from the group consisting of an upper housing, a lower housing, an inner housing, an outer housing, and combinations thereof, and wherein at least one of said at least one housing element is adapted for mechanical rotation of the microprotrusion array, and a support comprising a plurality of microprotrusions coupled to the support, said microprotrusions comprising at least one scraping edge and a length sufficient to disrupt the stratum corneum;
and rotating the microprotrusion array of said microabrader device against the skin at the delivery site with sufficient force for the microprotrusions to disrupt and penetrate the stratum corneum substantially without piercing the stratum corneum thereby allowing a substance to be delivered into the skin of the subject at the delivery site.
9. The method according to claim 8, wherein the abrader device comprises at least one rotation porting and at least one stationary portion and the rotating step is accomplished by manually rotating the rotating portion of said microabrader device at the delivery site on the skin of the subject.
10. The method according to claim 9, wherein the rotating step is accomplished by mechanically rotating the microabrader device.
CA2497154A 2002-08-29 2003-08-27 Substance delivery via a rotating microabrading surface Expired - Fee Related CA2497154C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US40669402P 2002-08-29 2002-08-29
US60/406,694 2002-08-29
PCT/US2003/026813 WO2004019777A2 (en) 2002-08-29 2003-08-27 Substance delivery via rotating mocroabrading surface

Publications (2)

Publication Number Publication Date
CA2497154A1 true CA2497154A1 (en) 2004-03-11
CA2497154C CA2497154C (en) 2012-01-03

Family

ID=31978342

Family Applications (3)

Application Number Title Priority Date Filing Date
CA2497154A Expired - Fee Related CA2497154C (en) 2002-08-29 2003-08-27 Substance delivery via a rotating microabrading surface
CA2497103A Expired - Fee Related CA2497103C (en) 2002-08-29 2003-08-27 Microabrader with controlled abrasion features
CA2497128A Expired - Fee Related CA2497128C (en) 2002-08-29 2003-08-27 Microprotrusion arrays and methods for using same to deliver substances into tissue

Family Applications After (2)

Application Number Title Priority Date Filing Date
CA2497103A Expired - Fee Related CA2497103C (en) 2002-08-29 2003-08-27 Microabrader with controlled abrasion features
CA2497128A Expired - Fee Related CA2497128C (en) 2002-08-29 2003-08-27 Microprotrusion arrays and methods for using same to deliver substances into tissue

Country Status (7)

Country Link
US (5) US7166086B2 (en)
EP (4) EP1531896B1 (en)
JP (3) JP4460451B2 (en)
AU (3) AU2003270011B8 (en)
CA (3) CA2497154C (en)
ES (4) ES2617576T3 (en)
WO (3) WO2004020015A2 (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE102008005940A1 (en) * 2008-01-24 2009-08-06 Fontaine Helmut La abrading

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