CA2496184A1 - Scaffolds with viable tissue - Google Patents

Scaffolds with viable tissue Download PDF

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Publication number
CA2496184A1
CA2496184A1 CA002496184A CA2496184A CA2496184A1 CA 2496184 A1 CA2496184 A1 CA 2496184A1 CA 002496184 A CA002496184 A CA 002496184A CA 2496184 A CA2496184 A CA 2496184A CA 2496184 A1 CA2496184 A1 CA 2496184A1
Authority
CA
Canada
Prior art keywords
tissue
scaffold
tissue scaffold
composite implant
pocket
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA002496184A
Other languages
French (fr)
Other versions
CA2496184C (en
Inventor
Stephanie M. Kladakis
Sridevi Dhanaraj
Robert Boock
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DePuy Mitek LLC
Original Assignee
DePuy Mitek LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by DePuy Mitek LLC filed Critical DePuy Mitek LLC
Publication of CA2496184A1 publication Critical patent/CA2496184A1/en
Application granted granted Critical
Publication of CA2496184C publication Critical patent/CA2496184C/en
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/40—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material
    • A61L27/44—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material having a macromolecular matrix
    • A61L27/48—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material having a macromolecular matrix with macromolecular fillers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/56—Porous materials, e.g. foams or sponges
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/58—Materials at least partially resorbable by the body

Abstract

A composite implant is provided for repairing a tissue defect in a patient. In one embodiment, the implant is a porous tissue scaffold having at least one pocket formed therein and adapted to contain a viable tissue. The tissue scaffold can have a variety of configurations, and in one embodiment it includes top and bottom portions that can be at least partially mated to one another, and in an exemplary embodiment that are heated sealed to one another around a perimeter thereof to form an enclosed pocket therebetween. The pocket is preferably sealed with a viable tissue disposed therein. In another embodiment, the tissue scaffold is substantially wedge-shaped and the pocket comprises a hollow interior formed in the tissue scaffold, and/or at least one lumen extending into the tissue scaffold. The tissue scaffold can also optionally include at least one surface feature formed thereof to promote blood vessel formation.

Claims (41)

  1. CLAIMS:
    A composite implant for repairing a tissue defect in a patient, comprising:
    a porous tissue scaffold formed from a bioresorbable, synthetic polymeric material and including at least one pocket formed therein adapted to contain a viable tissue.
  2. 2. The composite implant of claim 1, further comprising a viable tissue disposed within the at least one pocket in the scaffold and effective to migrate into the scaffold to integrate with native tissue surrounding the scaffold.
  3. The composite implant of claim 2, further comprising at least one bioactive substance applied to the viable tissue and effective to stimulate cell growth.
  4. 4. The composite implant of claim 3, wherein the bioactive substance is selected from the group consisting of a blood clots, platelet rich plasma, cartilage-derived morphogenic proteins, recombinant human growth factors, and combinations thereof.
  5. 5. The composite implant of claim 1, wherein the tissue scaffold includes top and bottom portions.
  6. 6. The composite implant of claim 5, wherein the top and bottom portions are at least partially mated to one another.
  7. 7. The composite implant of claim 5, wherein the top and bottom portions of the tissue scaffold are heated sealed to one another around a perimeter thereof to form an enclosed pocket therebetween.
  8. 8. The composite implant of claim 7, further comprising a viable tissue disposed within the enclosed pocket.
  9. 9. The composite implant of claim 1, wherein the tissue scaffold is substantially wedge-shaped and the pocket comprises a hollow interior formed in the tissue scaffold.
  10. 10. The composite implant of claim 1, wherein the tissue scaffold is substantially wedge-shaped, and the pocket comprises at least one lumen extending into the tissue scaffold.
  11. 11. The composite implant of claim 1, wherein the tissue scaffold includes at least one surface feature formed thereof to promote blood vessel formation.
  12. 12. The composite implant of claim 11, wherein the at least one surface feature comprises a plurality of channels formed on an outer surface of the tissue scaffold.
  13. 13. A composite implant for repairing a tissue defect in a patient, comprising:
    a porous tissue scaffold having at least one pocket formed therein; and a viable tissue disposed within the at least one pocket in the scaffold and effective to migrate into the scaffold to integrate with native tissue surrounding the scaffold, the viable tissue containing tissue fragments selected from the group consisting of minced, sliced, and slivered tissue fragments.
  14. 14. The composite implant of claim 13, wherein the tissue scaffold is foamed from at least one material selected from the group consisting of natural polymers, synthetic polymers, and combinations thereof.
  15. 15. The composite implant of claim 13, further comprising at least one bioactive substance applied to the viable tissue and effective to stimulate cell growth.
  16. 16. The composite implant of claim 15, wherein the bioactive substance is selected from the group consisting of a blood clots, platelet rich plasma, cartilage-derived morphogenic proteins, recombinant human growth factors, and combinations thereof.
  17. 17. The composite implant of claim 13, wherein the tissue scaffold includes top and bottom portions.
  18. 18. The composite implant of claim 17, wherein the top and bottom portions are at least partially mated to one another.
  19. 19. The composite implant of claim 17, wherein the top and bottom portions of the tissue scaffold are heated sealed to one another around a perimeter thereof to form an enclosed pocket therebetween containing the viable tissue.
  20. 20. The composite implant of claim 13, wherein the tissue scaffold is substantially wedge-shaped and the pocket comprises a hollow interior formed in the tissue scaffold.
  21. 21. The composite implant of claim 13, wherein the tissue scaffold is substantially wedge-shaped, and the pocket comprises at least one lumen extending into the tissue scaffold.
  22. 22. The composite implant of claim 13, wherein the tissue scaffold includes at least one surface feature formed thereof to promote blood vessel formation.
  23. 23. The composite implant of claim 22, wherein the at least one surface feature comprises a plurality of channels formed on an outer surface of the tissue scaffold.
  24. 24. A method for repairing defective tissue, comprising:
    providing a tissue scaffold formed from a bioresorbable, synthetic polymeric material having at least one pocket formed therein and adapted to contain a viable tissue;
    obtaining a viable tissue;
    loading the viable tissue into the at least one pocket of the tissue scaffold;
    and implanting the tissue scaffold with the viable tissue disposed therein at a defect site in a patient's body.
  25. 25. The method of claim 24, further comprising the step of applying at least one bioactive substance to the viable tissue to stimulate cell growth.
  26. 26. The method of claim 25, wherein the bioactive substance is selected from the group consisting of a blot clots, platelet rich plasma, cartilage-derived morphogenic proteins, recombinant human growth factors, and combinations thereof.
  27. 27. The method of claim 24, wherein the tissue scaffold includes top and bottom portions.
  28. 28. The method of claim 27, wherein the top and bottom portions are at least partially mated to one another.
  29. 29. The method of claim 27, wherein the top and bottom portions of the tissue scaffold are heated sealed to one another around a perimeter thereof to form an enclosed pocket therebetween containing the viable tissue.
  30. 30. The method of claim 24, wherein the tissue scaffold is substantially wedge-shaped and the pocket comprises a hollow interior formed in the tissue scaffold.
  31. 31. The method of claim 24, wherein the tissue scaffold is substantially wedge-shaped, and the pocket comprises at least one lumen extending into the tissue scaffold.
  32. 32. The method of claim 24, wherein the tissue scaffold includes at least one surface feature formed thereof to promote blood vessel formation.
  33. 33. The method of claim 32, wherein the at least one surface feature comprises a plurality of channels formed on an outer surface of the tissue scaffold.
  34. 34. A method for repairing defective tissue, comprising:
    providing a tissue scaffold having at least one pocket formed therein and adapted to contain a viable tissue;
    obtaining a viable tissue;
    preparing the viable tissue to form tissue fragments selected from the group consisting of minced, sliced, and slivered tissue fragments;
    loading the tissue fragments into the at least one pocket of the tissue scaffold;
    and implanting the tissue scaffold with the tissue fragments disposed therein at a defect site in a patient's body.
  35. 35. The method of claim 34, wherein the tissue scaffold is formed from at least one material selected from the group consisting of natural polymers, synthetic polymers, and combinations thereof.
  36. 36. The method of claim 34, further comprising the step of applying at least one bioactive substance to the tissue fragments to stimulate cell growth.
  37. 37. The method of claim 36, wherein the bioactive substance is selected from the group consisting of a blood clots, platelet rich plasma, cartilage-derived morphogenic proteins, recombinant human growth factors, and combinations thereof.
  38. 38. The method of claim 34, wherein the tissue scaffold is substantially wedge-shaped and the pocket comprises a hollow interior formed in the tissue scaffold.
  39. 39. The method of claim 34, wherein the tissue scaffold is substantially wedge-shaped, and the pocket comprises at least one lumen extending into the tissue scaffold.
  40. 40. The method of claim 34, wherein the tissue scaffold includes at least one surface feature formed thereof to promote blood vessel formation.
  41. 41. The method of claim 40, wherein the at least one surface feature comprises a plurality of channels formed on an outer surface of the tissue scaffold.
CA2496184A 2004-02-09 2005-02-08 Scaffolds with viable tissue Expired - Fee Related CA2496184C (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US10/775,034 2004-02-09
US10/775,034 US11395865B2 (en) 2004-02-09 2004-02-09 Scaffolds with viable tissue

Publications (2)

Publication Number Publication Date
CA2496184A1 true CA2496184A1 (en) 2005-08-09
CA2496184C CA2496184C (en) 2012-04-24

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
CA2496184A Expired - Fee Related CA2496184C (en) 2004-02-09 2005-02-08 Scaffolds with viable tissue

Country Status (5)

Country Link
US (2) US11395865B2 (en)
EP (1) EP1561481B1 (en)
JP (1) JP4717459B2 (en)
AU (1) AU2005200305B2 (en)
CA (1) CA2496184C (en)

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US20220331491A1 (en) 2022-10-20
US20050177249A1 (en) 2005-08-11
AU2005200305A1 (en) 2005-08-25
US11395865B2 (en) 2022-07-26
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AU2005200305B2 (en) 2007-01-04
EP1561481A3 (en) 2006-03-08

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