CA2495537A1 - Immunoregulatory compounds and derivatives and methods of treating diseases therewith - Google Patents
Immunoregulatory compounds and derivatives and methods of treating diseases therewith Download PDFInfo
- Publication number
- CA2495537A1 CA2495537A1 CA002495537A CA2495537A CA2495537A1 CA 2495537 A1 CA2495537 A1 CA 2495537A1 CA 002495537 A CA002495537 A CA 002495537A CA 2495537 A CA2495537 A CA 2495537A CA 2495537 A1 CA2495537 A1 CA 2495537A1
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
- A61K31/196—Carboxylic acids, e.g. valproic acid having an amino group the amino group being directly attached to a ring, e.g. anthranilic acid, mefenamic acid, diclofenac, chlorambucil
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
- A61K31/235—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids having an aromatic ring attached to a carboxyl group
- A61K31/24—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids having an aromatic ring attached to a carboxyl group having an amino or nitro group
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C229/40—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino groups bound to carbon atoms of at least one six-membered aromatic ring and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
- C07C229/42—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino groups bound to carbon atoms of at least one six-membered aromatic ring and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton with carboxyl groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by saturated carbon chains
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C245/00—Compounds containing chains of at least two nitrogen atoms with at least one nitrogen-to-nitrogen multiple bond
- C07C245/02—Azo compounds, i.e. compounds having the free valencies of —N=N— groups attached to different atoms, e.g. diazohydroxides
- C07C245/06—Azo compounds, i.e. compounds having the free valencies of —N=N— groups attached to different atoms, e.g. diazohydroxides with nitrogen atoms of azo groups bound to carbon atoms of six-membered aromatic rings
- C07C245/08—Azo compounds, i.e. compounds having the free valencies of —N=N— groups attached to different atoms, e.g. diazohydroxides with nitrogen atoms of azo groups bound to carbon atoms of six-membered aromatic rings with the two nitrogen atoms of azo groups bound to carbon atoms of six-membered aromatic rings, e.g. azobenzene
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Abstract
Compounds are disclosed having the structure of Formula (I), where R1, R3, and R4 are independently hydrogen or C1 to C4 alkyl, and R2 is (II), where R5 is selected from the group consisting of hydrogen and C1 to C4 alkyl, or (III), where R6, R7 in R8 are independently hydrogen or C1 to C4 alkyl; or the esters or pharmacologically acceptable salts thereof. Such compounds may be utilized for the prophylaxis or treatment of various diseases, particularly inflammatory conditions of the GI tract. Methods of treating inflammatory conditions of the GI tract such as inflammatory bowel disease using compounds having the following formula are also disclosed (IV), where R9, R10 and R11 are independently selected from the group consisting of hydrogen and C1 to C4 alkyl, and R12 is selected from the group consisting of hydrogen and -C(O)R13, where R13 is a C1 to C6 alkyl or an aryl group.
Claims (17)
1. Use of a compound of Formula II:
where R9, R10 and R11 are independently selected from the group consisting of hydrogen and C1 to C4 alkyl; and R12 is selected from the group consisting of hydrogen and -C(O)R13, where R13 is a C1 to C6 alkyl or an aryl group;
or an ester or a pharmaceutically acceptable salt of such compound to treat an inflammatory condition of the gastrointestinal tract in a subject in need of such treatment.
where R9, R10 and R11 are independently selected from the group consisting of hydrogen and C1 to C4 alkyl; and R12 is selected from the group consisting of hydrogen and -C(O)R13, where R13 is a C1 to C6 alkyl or an aryl group;
or an ester or a pharmaceutically acceptable salt of such compound to treat an inflammatory condition of the gastrointestinal tract in a subject in need of such treatment.
2. The use according to Claim 1, wherein R9, R10, and R11 are independently selected from the group consisting of H, CH3, CH2CH3, and CH(CH3)2.
3. The use according to Claim 1, wherein R9, R10, and R11 are independently selected from the group consisting of H and CH3.
4. The use according to Claim 1, wherein R12 is hydrogen.
5. The use according to Claim 1, wherein the compound of Formula II is 4-aminophenylacetic acid.
6. The use according to any one of Claims 1 to 5, wherein the inflammatory condition of the gastrointestinal tract is ulcerative colitis.
7. The use according to any one of Claims 1 to 5, wherein the inflammatory condition of the gastrointestinal tract is Crohn's disease.
8. The use according to any one of Claims 1 to 7, wherein the compound is orally administrable.
9. The use according to any one of Claims 1 to 7, wherein the compound is rectally administrable.
10. The use according to any one of claims 1 to 9 wherein the compound is used in admixture with a pharmaceutical diluent or carrier.
11. Use of an active pharmaceutical ingredient comprising (a) at least one compound selected from the group consisting of 4-aminophenylacetic acid, an ester thereof and a pharmaceutically acceptable salt thereof and (b) at least one compound selected from the group consisting of 5-aminosalicylic acid, an ester thereof and a pharmaceutically acceptable salt thereof.
12. The use according to Claim 11, wherein the 4-aminophenylacetic acid or ester or salt thereof is from about 10 to about 90 weight percent of the active pharmaceutical ingredient.
13. The use according to Claim 11 wherein the molar ratio of the 4-aminophenylacetic acid to the 5-aminosalicylic acid is between about 1:10 and about 10:1.
14. The use according to any one of Claims 11 to 13, wherein the inflammatory condition of the gastrointestinal tract is ulcerative colitis.
15. The use according to any one of Claims 11 to 14, wherein the inflammatory condition of the gastrointestinal tract is Crohn's disease.
16. The use according to any one of Claims 11 to 15, wherein the active pharmaceutical ingredient is orally administrable.
17. The use according to any one of Claims 11 to 15, wherein the active pharmaceutical ingredient is rectally administrable.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US22868300P | 2000-08-29 | 2000-08-29 | |
US60/228,683 | 2000-08-29 | ||
CA002420576A CA2420576C (en) | 2000-08-29 | 2001-08-28 | Immunoregulatory compounds, derivatives thereof and their use |
Related Parent Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CA002420576A Division CA2420576C (en) | 2000-08-29 | 2001-08-28 | Immunoregulatory compounds, derivatives thereof and their use |
Publications (2)
Publication Number | Publication Date |
---|---|
CA2495537A1 true CA2495537A1 (en) | 2002-03-07 |
CA2495537C CA2495537C (en) | 2010-03-30 |
Family
ID=22858180
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CA2495537A Expired - Lifetime CA2495537C (en) | 2000-08-29 | 2001-08-28 | Immunoregulatory compounds and derivatives and methods of treating diseases therewith |
CA002420576A Expired - Lifetime CA2420576C (en) | 2000-08-29 | 2001-08-28 | Immunoregulatory compounds, derivatives thereof and their use |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CA002420576A Expired - Lifetime CA2420576C (en) | 2000-08-29 | 2001-08-28 | Immunoregulatory compounds, derivatives thereof and their use |
Country Status (16)
Country | Link |
---|---|
US (5) | US6583128B2 (en) |
EP (2) | EP1642885B1 (en) |
JP (1) | JP4163946B2 (en) |
AT (2) | ATE448194T1 (en) |
AU (3) | AU2001285311B2 (en) |
CA (2) | CA2495537C (en) |
CY (1) | CY1110593T1 (en) |
DE (2) | DE60115465T2 (en) |
DK (2) | DK1642885T3 (en) |
ES (2) | ES2333337T3 (en) |
HK (2) | HK1054221A1 (en) |
IL (3) | IL154536A0 (en) |
MX (1) | MXPA03001787A (en) |
PT (1) | PT1642885E (en) |
TW (1) | TWI249519B (en) |
WO (1) | WO2002018324A2 (en) |
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US7648962B2 (en) * | 2002-11-26 | 2010-01-19 | Biocon Limited | Natriuretic compounds, conjugates, and uses thereof |
DE60331584D1 (en) * | 2002-11-26 | 2010-04-15 | Biocon Ltd | MODIFIED NATRIURETIC COMPOUNDS, CONJUGATES, AND ITS USES |
WO2005058367A2 (en) * | 2003-12-16 | 2005-06-30 | Nektar Therapeutics Al, Corporation | Pegylated small molecules |
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US8198328B2 (en) * | 2004-01-21 | 2012-06-12 | New York University | Treatment of cancer using benzoic acid derivatives |
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ES2687039T3 (en) | 2004-03-23 | 2018-10-23 | Biocon Limited | Methods and compositions employing 4-aminophenylacetic acid compounds |
ATE472999T1 (en) * | 2004-05-28 | 2010-07-15 | Salix Pharmaceuticals Inc | PREVENTION, TREATMENT AND RELIEF OF RADIATION-INDUCED ENTERITIS |
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