CA2494017A1 - Delayed release anti-viral product, use and formulation thereof - Google Patents
Delayed release anti-viral product, use and formulation thereof Download PDFInfo
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- CA2494017A1 CA2494017A1 CA002494017A CA2494017A CA2494017A1 CA 2494017 A1 CA2494017 A1 CA 2494017A1 CA 002494017 A CA002494017 A CA 002494017A CA 2494017 A CA2494017 A CA 2494017A CA 2494017 A1 CA2494017 A1 CA 2494017A1
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
- A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7048—Compounds having saccharide radicals and heterocyclic rings having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin, digitoxin or digoxin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
- A61K9/1652—Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/2031—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, polyethylene oxide, poloxamers
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
- A61K9/2077—Tablets comprising drug-containing microparticles in a substantial amount of supporting matrix; Multiparticulate tablets
- A61K9/2081—Tablets comprising drug-containing microparticles in a substantial amount of supporting matrix; Multiparticulate tablets with microcapsules or coated microparticles according to A61K9/50
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5005—Wall or coating material
- A61K9/5015—Organic compounds, e.g. fats, sugars
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5005—Wall or coating material
- A61K9/5021—Organic macromolecular compounds
- A61K9/5026—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5005—Wall or coating material
- A61K9/5021—Organic macromolecular compounds
- A61K9/5036—Polysaccharides, e.g. gums, alginate; Cyclodextrin
- A61K9/5042—Cellulose; Cellulose derivatives, e.g. phthalate or acetate succinate esters of hydroxypropyl methylcellulose
- A61K9/5047—Cellulose ethers containing no ester groups, e.g. hydroxypropyl methylcellulose
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5084—Mixtures of one or more drugs in different galenical forms, at least one of which being granules, microcapsules or (coated) microparticles according to A61K9/16 or A61K9/50, e.g. for obtaining a specific release pattern or for combining different drugs
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61P31/12—Antivirals
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- A61P31/14—Antivirals for RNA viruses
- A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
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- A—HUMAN NECESSITIES
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- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/20—Antivirals for DNA viruses
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- A—HUMAN NECESSITIES
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- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/20—Antivirals for DNA viruses
- A61P31/22—Antivirals for DNA viruses for herpes viruses
Abstract
An anti-viral product is comprised of at least three delayed release dosages forms, each of which has a different release profile, with the C~,ax for the anti-viral product being reached in less than about twelve hours after initial release of anti-viral from the product.
Description
DELAYED RELEASE ANTI-VIRAL PRODUCT, USE AND
FORMULATION THEREOF
This invention relates to an anti-viral product, as well as the use and formulation thereof.
A wide variety of anti-virals have been used, and will be used, in order to combat bacterial infection. In general, such anti-virals can be administered by a repeated dosing of immediate release dosage forms, which results in poor compliance or as a controlled release formulation (slow release) at higher administered doses. The present invention is directed to providing for an improved anti-viral product.
In accordance with one aspect of the present invention, there is provided ~ an anti-viral pharmaceutical product which is comprised of at least two, preferably at least three, anti-viral dosage forms. Such dosage forms are formulated so that each of the dosage forms has a different release profile.
In a particularly preferred embodiment, there are at least two, preferably at least three dosage forms, each of which has a different release profile and the release profile of each of the dosage forms is such that the dosage forms each start release of the anti-viral contained therein at different times after administration of the anti-viral product.
Thus, in accordance with an aspect of the present invention, there is provided a single or unitary anti-viral product that has contained therein at least two, preferably at least three anti-viral dosage forms, each of which has a different release profile, whereby the anti-viral contained in each of such dosage forms is released at different times.
In accordance with a further aspect of the invention, the anti-viral product may be comprised of at least four different dosage fonns, each of which starts to release the anti-viral contained therein at different times after administration of the anti-viral product.
The anti-viral product generally does not include more than five dosage forms with different release times.
In accordance with a preferred embodiment, the anti-viral product has an overall release profile such that when administered the maximum serum concentration of the total anti-viral released from the product is reached in less than twelve hours, preferably in less than eleven hours in each case after initial release of the anti-viral. In an embodiment, the maximum serum concentration of the total anti-viral released from the anti-viral product is achieved no earlier than four hours after initial release of the anti-viral.
In accordance with one preferred embodiment of the invention, there are at least three dosage forms, each of which is a delayed release dosage form (which may be a pH
sensitive or a non-pH sensitive delayed dosage form, depending on the type of anti-viral product). More particularly, the anti-viral release from the second of the at least three dosage forms achieves a C~,aX (maximum serum concentration in the serum) at a time after the anti-viral released from the first of the at least three dosage forms achieves a ~inax in the serum, and the anti-viral released from the third dosage form achieves a Cmax in the serum after the C",~ of anti-viral released from the second dosage form. As used herein first, second, third, etc., refers to the order in which anti-viral is released from the dosage form.
FORMULATION THEREOF
This invention relates to an anti-viral product, as well as the use and formulation thereof.
A wide variety of anti-virals have been used, and will be used, in order to combat bacterial infection. In general, such anti-virals can be administered by a repeated dosing of immediate release dosage forms, which results in poor compliance or as a controlled release formulation (slow release) at higher administered doses. The present invention is directed to providing for an improved anti-viral product.
In accordance with one aspect of the present invention, there is provided ~ an anti-viral pharmaceutical product which is comprised of at least two, preferably at least three, anti-viral dosage forms. Such dosage forms are formulated so that each of the dosage forms has a different release profile.
In a particularly preferred embodiment, there are at least two, preferably at least three dosage forms, each of which has a different release profile and the release profile of each of the dosage forms is such that the dosage forms each start release of the anti-viral contained therein at different times after administration of the anti-viral product.
Thus, in accordance with an aspect of the present invention, there is provided a single or unitary anti-viral product that has contained therein at least two, preferably at least three anti-viral dosage forms, each of which has a different release profile, whereby the anti-viral contained in each of such dosage forms is released at different times.
In accordance with a further aspect of the invention, the anti-viral product may be comprised of at least four different dosage fonns, each of which starts to release the anti-viral contained therein at different times after administration of the anti-viral product.
The anti-viral product generally does not include more than five dosage forms with different release times.
In accordance with a preferred embodiment, the anti-viral product has an overall release profile such that when administered the maximum serum concentration of the total anti-viral released from the product is reached in less than twelve hours, preferably in less than eleven hours in each case after initial release of the anti-viral. In an embodiment, the maximum serum concentration of the total anti-viral released from the anti-viral product is achieved no earlier than four hours after initial release of the anti-viral.
In accordance with one preferred embodiment of the invention, there are at least three dosage forms, each of which is a delayed release dosage form (which may be a pH
sensitive or a non-pH sensitive delayed dosage form, depending on the type of anti-viral product). More particularly, the anti-viral release from the second of the at least three dosage forms achieves a C~,aX (maximum serum concentration in the serum) at a time after the anti-viral released from the first of the at least three dosage forms achieves a ~inax in the serum, and the anti-viral released from the third dosage form achieves a Cmax in the serum after the C",~ of anti-viral released from the second dosage form. As used herein first, second, third, etc., refers to the order in which anti-viral is released from the dosage form.
In one embodiment, the second of the at least two dosage forms initiates release of the anti-viral contained therein at least one hour after the first dosage form initiates release, with the initiation of the release therefrom generally occurring no more than six hours after initiation of release of anti-viral from the first dosage form of the at least three dosage forms.
In general, the first dosage form produces a C~,~ for the anti-viral released therefrom within from about 0.5 to about 2 hours after initiation of release, with the second dosage form of the at least three dosage forms producing a CmaX for the anti-viral released therefrom in no more than about four hours after initiation of release from the first dosage form. Thus, Cmax for the second dosage form is achieved after Cmax for the first dosage form and generally in no more than about 2 to about 3.5 hours after C",~ is achieved from the first dosage form. In general, the Cm~ for such second dosage form is achieved no earlier than two hours after initiation of release from the first dosage form;
however, it is possible within the scope of the invention to achieve Cmax in a shorter period of time.
As hereinabove indicated, the anti-viral product may contain at least three or at least four or more different dosage forms. For example, if the anti-viral product includes a third dosage form, the anti-viral released therefrom reaches a CmaX at a time later than the Cmax is achieved fox the anti-viral released from each of the first and second dosage fomns. In a preferred embodiment, release of anti-viral from the third ,dosage form is started after initiation of release of anti-viral from both the first dosage form and the second dosage form. In one embodiment, CmaX for anti-viral release from the third dosage form is achieved within eight hours after initiation of release from the first dosage form.
In general, the first dosage form initiates release of anti-viral at a time later than anti-viral would be released from an immediate release dosage form. For example, the first dosage form would initiate release within 1 to four hours after administration of the product.
Tn another embodiment, the anti-viral product contains at least four delayed release dosage forms, with each of the at least four dosage forms having different release profiles, whereby the anti-viral release from each of the at least four different dosage forms achieves a Cmax at a different time.
As hereinabove indicated, in a preferred embodiment, irrespective of whether the anti-viral contains at least two or at least three or at least four different delayed release dosage forms each with a different release profile, C~"~ for all the anti-viral released from the anti-viral product is achieved in less than twelve hours after release is initiated from the first dosage form., and more generally is achieved in Iess than eleven hours.
In a preferred embodiment, the anti-viral product is a once a day product, whereby after administration of the anti-viral product, no further product is administered during the day; i.e., the preferred regimen is that the product is administered only once over a twenty-four hour period. Thus, in accordance with the present invention, there is a single administration of an anti-viral product with the anti-viral being released in a manner such that overall anti-viral release is effected with different release profiles in a manner such that the overall C",~ for the anti-viral product is reached in less than twelve hours after first release of anti-viral. The term single administration means that the total anti-viral administered over a twenty-four hour period is administered at the same time, which can be a single tablet or capsule or two or more thereof, provided that they are administered at essentially the same time.
Applicant has found that a single dosage anti-viral product comprised of at least three anti-viral dosage forms each having a different release profile is an improvement over a single dosage anti-viral product comprised of an anti-viral dosage form having a single release profile. Each of the dosage forms of anti-viral in a pharmaceutically acceptable carrier may have one or more anti-virals and each of the dosage forms may have the same anti-viral or different anti-virals.
In general, the first dosage form produces a C~,~ for the anti-viral released therefrom within from about 0.5 to about 2 hours after initiation of release, with the second dosage form of the at least three dosage forms producing a CmaX for the anti-viral released therefrom in no more than about four hours after initiation of release from the first dosage form. Thus, Cmax for the second dosage form is achieved after Cmax for the first dosage form and generally in no more than about 2 to about 3.5 hours after C",~ is achieved from the first dosage form. In general, the Cm~ for such second dosage form is achieved no earlier than two hours after initiation of release from the first dosage form;
however, it is possible within the scope of the invention to achieve Cmax in a shorter period of time.
As hereinabove indicated, the anti-viral product may contain at least three or at least four or more different dosage forms. For example, if the anti-viral product includes a third dosage form, the anti-viral released therefrom reaches a CmaX at a time later than the Cmax is achieved fox the anti-viral released from each of the first and second dosage fomns. In a preferred embodiment, release of anti-viral from the third ,dosage form is started after initiation of release of anti-viral from both the first dosage form and the second dosage form. In one embodiment, CmaX for anti-viral release from the third dosage form is achieved within eight hours after initiation of release from the first dosage form.
In general, the first dosage form initiates release of anti-viral at a time later than anti-viral would be released from an immediate release dosage form. For example, the first dosage form would initiate release within 1 to four hours after administration of the product.
Tn another embodiment, the anti-viral product contains at least four delayed release dosage forms, with each of the at least four dosage forms having different release profiles, whereby the anti-viral release from each of the at least four different dosage forms achieves a Cmax at a different time.
As hereinabove indicated, in a preferred embodiment, irrespective of whether the anti-viral contains at least two or at least three or at least four different delayed release dosage forms each with a different release profile, C~"~ for all the anti-viral released from the anti-viral product is achieved in less than twelve hours after release is initiated from the first dosage form., and more generally is achieved in Iess than eleven hours.
In a preferred embodiment, the anti-viral product is a once a day product, whereby after administration of the anti-viral product, no further product is administered during the day; i.e., the preferred regimen is that the product is administered only once over a twenty-four hour period. Thus, in accordance with the present invention, there is a single administration of an anti-viral product with the anti-viral being released in a manner such that overall anti-viral release is effected with different release profiles in a manner such that the overall C",~ for the anti-viral product is reached in less than twelve hours after first release of anti-viral. The term single administration means that the total anti-viral administered over a twenty-four hour period is administered at the same time, which can be a single tablet or capsule or two or more thereof, provided that they are administered at essentially the same time.
Applicant has found that a single dosage anti-viral product comprised of at least three anti-viral dosage forms each having a different release profile is an improvement over a single dosage anti-viral product comprised of an anti-viral dosage form having a single release profile. Each of the dosage forms of anti-viral in a pharmaceutically acceptable carrier may have one or more anti-virals and each of the dosage forms may have the same anti-viral or different anti-virals.
It is to be understood that when it is disclosed herein that a dosage form initiates release after another dosage form, such terminology means that the dosage form is designed and is intended to produce such later initiated release. It is known in the art, however, notwithstanding such design and intent, some "leakage" of anti-viral may occur.
Such "leakage" is not "release" as used herein.
If at least four 'dosage forms are used, the fourth of the at Ieast four dosage form may be a sustained release dosage form or a delayed release dosage form. If the fourth dosage form is a sustained release dosage form, even though Crn~ of the fourth dosage form of the at least four dosage forms is reached after the CmaX of each of the other dosage forms is reached, anti-viral release from such fourth dosage form may be initiated prior to or after release from the second or third dosage form.
The anti-viral product of the present invention, as hereinabove described, may be formulated for administration by a variety of routes of administration. For example, the anti-viral product may be formulated in a way that is suitable for topical administration;
administration in the eye or the ear; rectal or vaginal administration; as nose drops; by inhalation; as an injectable; or for oral administration. In a preferred embodiment, the anti-viral product is formulated in a manner such that it is suitable for oral administration.
For example, in formulating the anti-viral product for topical administration, such as by application to the skin, the at least two difFerent dosage forms, each of which contains an anti-viral, may be formulated for topical administration by including such dosage forms in an oil-in-water emulsion, or a water-in-oil emulsion. In such a formulation, the immediate release dosage form is in the continuous phase, and the delayed release dosage form is in a discontinuous phase. The formulation may also be produced in a manner for delivery of three dosage forms as hereinabove described. For example, there may be provided an oil-in-water-in-oil emulsion, with oil being a continuous phase that contains the immediate release component, water dispersed in the oil containing a first delayed release dosage form, and oil dispersed in the water containing a third delayed release dosage form.
It is also within the scope of the invention to provide an anti-viral product in the form of a patch, which includes anti-viral dosage forms having different release profiles, as hereinabove described.
In addition, the anti-viral product may be formulated fox use in the eye or ear or nose, for example, as a liquid emulsion. For example, the dosage form may be coated with a hydrophobic polymer whereby a dosage form is in the oil phase of the emulsion, and a dosage form may be coated with hydrophilic polymer, whereby a dosage form is in the water phase of the emulsion.
Furthermore, the anti-viral product with at least three different dosage forms with different release profiles may be formulated for rectal or vaginal administration, as known in the art. This may take the form of a cream or emulsion, or other dissolvable dosage form similar to those used for topical administration.
As a further embodiment, the anti-viral product may be formulated for use in inhalation therapy by coating the particles and micronizing the particles for inhalation.
In a preferred embodiment, the anti-viral product is formulated in a manner suitable for oral administration. Thus, for example, for oral administration, each of the dosage forms may be used as a pellet or a particle, with a pellet or particle then being formed into a unitary pharmaceutical product, for example, in a capsule, or embedded in a tablet, or suspended in a liquid for oral administration.
Alternatively, in formulating an oral delivery system, each of the dosage forms of the product may be formulated as a tablet, with each of the tablets being put into a capsule to produce a unitary anti-viral product. Thus, for example, anti-viral products may include a first dosage form in the form of a tablet that is an immediate release tablet, and may also include two or more additional tablets, each of which provides for a delayed release of the anti-viral, as hereinabove described, whereby the Cm~ of the anti-viral and where there are five delayed release components, the first delayed release component provides from ~ 0% to 25%, by weight, of the total anti-viral.
With respect to the delayed release components, where there are three delayed release components, the second delayed release component provides from 30% to 60%, by weight, of the total anti-viral provided by the second and third delayed release components with the third delayed release component providing the remainder of the anti-viral.
Where there are four delayed release components, the second released component provides 20% to 35% by weight of the total anti-viral provided by the second, third and fourth delayed release components, the next in time delayed release component provides from 20% to 40%, by weight, of the anti-viral provided by the second, third and fourth delayed release components and the last in time providing the remainder of the anti-viral provided by the second, third and fourth delayed release components.
When there are five delayed release components, the second delayed release component provides from 15% to 30%, by weight, the next in time delayed release component provides from 15% to 30%, the next in time delayed release component provides from 20% to 35%, by weight, and the last in time delayed release component provides from 20% to 35%, by weight, in each case of the total anti-viral provided by the second, third, fourth and fifth delayed release components.
An Immediate Release Component The immediate release portion of this system can be a mixture of ingredients that breaks down quicldy after administration to release the anti-viral. This can take the form of either a discrete pellet or granule that is mixed in with, or compressed with, the other three components.
released from each of the tablets is reached at different times, with the C~aX
of the total anti-viral released from the anti-viral product being achieved in less than twelve hours after anti-viral is first released.
The formulation of an anti-viral product including at least three dosage forms with different release profiles for different routes of administration is deemed to be within the skill of the art from the teachings herein. As known in the art, with respect to delayed release, the time of release can be controlled by the concentration of anti-virals in the coating and/or the thickness of the coating.
In formulating an anti-viral product in accordance with the invention, in one embodiment, the first dosage form of the product generally provides from about 20% to about 50% of the total dosage of anti-viral to be delivered by the product, with such first dosage form generally providing at least 25% of the total dosage of the anti-viral to be delivered by the product. In many cases, the first dosage form provides from about 20%
to about 30% of the total dosage of anti-viral to be delivered by the product;
however, in some cases it may be desirable to have the first dosage form provide for about 45% to about 50% of the total dosage of anti-viral to be delivered by the product.
The remaining dosage forms deliver the remainder of the anti-viral. In one embodiment, each of the delayed release dosage forms after the first delayed release dosage form may provide about equal amounts of anti-viral; however, they may also be formulated so as to provide different amounts.
In accordance with the present invention, each of the dosage fonns contains the same anti-viral; however, each of the dosage forms may contain more than one anti-viral.
Tn one embodiment, where the composition contains three delayed release components, the first component provides from 20% to 35% (preferably 20% to 30%), by weight, of the total anti-viral; where there is four delayed release components, the first delayed release component provides from 15% to 30%, by weight, of the total anti-viral;
The materials to be added to the anti-virals for the immediate release component can be, but are not limited to, microcrystalline cellulose, corn starch, pregelatinized starch, potato starch, rice starch, sodium carboxyrnethyl starch, hydroxypropylcellulose, hydroxypropylmethylcellulose, hydroxyethylcellulose, ethylcellulose, chitosan, hydroxychitosan, hydroxymethylatedchitosan, cross-Iinked chitosan, cross-linked hydroxymethyl chitosan, maltodextrin, mannitol, sorbitol, dextrose, maltose, fructose, glucose, levulose, sucrose, polyvinylpyrrolidone (PVP), acrylic acid derivatives (Carbopol, Eudragit, etc.), polyethylene glycols, such a low molecular weight PEGs (PEG2000-10000) and high molecular weight PEGS (Polyox) with molecular weights above 20,000 daltons.
It may be useful to have these materials present in the range of 1.0 to 60%
(W/W).
In addition, it may be useful to have other ingredients in this system to aid in the dissolution of the drug, or the breakdown of the component after ingestion or administration. These ingredients can be surfactants, such as sodium Iauryl sulfate, sodium monoglycerate, sorbitan monooleate, sorbitan monooleate, polyoxyethylene sorbitan monooleate, glyceryl monosteaxate, glyceryl monooleate, glyceryl monobutyrate, one of the non-ionic surfactants such as the Pluronic line of surfactants, or any other material with surface active properties, or any combination of the above.
These materials may be present in the rate of 0.05-15% (WlW).
~'he non-pH Sensitive Delayed Release Component The components in this composition are the same immediate release unit, but with additional polymers integrated into the composition, or as coatings over the pellet or granule.
Materials that can be used to obtain a delay in release suitable for this component of the invention can be, but are not limited to, polyethylene glycol (PEG) with molecular weight above 4,000 daltons (Carbowax, Polyox), waxes such as white wax or bees wax, paraffin, acrylic acid derivatives (Eudragit), propylene glycol, and ethylcellulose.
Typically these materials can be present in the range of 0.5-25% (W/W) of this component.
The pH Sensitive (Enteric) Release Component The components in this composition are the same as the immediate release component, but with additional polymers integrated into the composition, or as coatings over the pellet or granule.
The kind of materials useful for this purpose can be, but are not limited to, cellulose acetate pthalate, Eudragit L, and other pthalate salts of cellulose derivatives.
These materials can be present in concentrations from 4-20% (W/W).
Sustained Release Component The components in this composition are the same as the immediate release component, but with additional polymers integrated into the composition, or as coatings over the pellet or granule.
The kind of materials useful for this purpose can be, but are not limited to, ethylcellulose,hydroxypropylmethylcellulose,hydroxypropylcellulose, hydroxyethylcellulose, carboxymethylcellulose, methylcellulose, nitrocellulose, Eudragit R, and Eudragit RL, Carbopol, or polyethylene glycols with molecular weights in excess of 8,000 daltons.
These materials can be present in concentrations from 4-20% (WlW).
As hereinabove indicated, the units comprising the anti-viral composition of the present invention can be in the form of discrete pellets or particles contained in the capsule, or particles embedded in a tablet or suspended in a liquid suspension.
The anti-viral composition of the present invention may be administered, for example, by any of the following routes of administration: sublingual, transmucosal, transdermal, parenteral, etc., and preferably is administered orally. The composition includes a therapeutically effective amount of the anti-viral, which amount will vary with the anti-viral to be used, the disease or infection to be treated, and the number of times that the composition is to be delivered in a day. The composition is administered to a host in an amount effective for treating a bacterial infection.
The following are representative examples of some antivirals that may be used in the product of the invention: Acyclovir, Amantadine, Amprenavir, Cidofovir, Delavirdine, Didanosine, Famciclovir, Foscarnet, Ganciclovir, Indinavir, Interferon, Lamivudine, Nelfinavir, Nevirapine, Palivizumab, Penciclovir, Ribavirin, Rimantadine, Ritonavir, Saquinavir, Stavudine, Trifluridine, Valacyclovir, Vidarabine, Zalcitabine, Zidovudine The invention will be further described with respect to the following examples;
however, the scope of the invention is not limited thereby. All percentages in this specification, unless otherwise specified, are by weight.
A,ntiviral Examples non-pH Sensitive Delayed Release Component Formulate the composition by mixing the ingredients in a suitable pharmaceutical mixer or granulator such as a planetary mixer, high-shear granulator, fluid bed granulator, or extruder, in the presence of water or other solvent, or in a hot melt process. If water or other solvent was used, dry the blend in a suitable pharmaceutical drier, such as a vacuum over or forced-air oven. Allow the product to cool, the product may be sieved or granulated, and compressed using a suitable tablet press, such as a rotary tablet press.
In ear diem Conc. (% W/W) Example 1: Fluorouracil 65% (W/W) Microcxystalline cellulose 20 Polyox 7.5 Croscarmellose sodium 7.5 Example 2: Fluorouracil 55% (W/V~
Microcrystalline cellulose 25 Polyox 10 Glyceryl monooleate 10 Example 3: Fluorouracil 75% (W/W) Polyox 10 Hydroxypropylcellulose 5 Croscarmellose sodium 10 Example 4.: Dexamethasone 65% (W/W) Microcrystalline cellulose 20 Polyox 7.5 Croscarmellose sodium 7.5 Example 5: Dexamethasone 55% (W/W) Microcrystalline cellulose 25 Polyox 10 Glyceryl monooleate 10 Example 6: Dexamethasone 75% (W/W) Polyox 10 Hydroxypropylcellulose 5 Croscarmellose sodium 10 Example 7: Valrubicin 65% (W/W) Microcrystalline cellulose 20 Polyox 7. S
Croscarmellose sodium 7.S
Example 8: Valrubicin SS% (W/W) Microcrystalline cellulose 2S
Polyox 10 Glyceryl monooleate 10 Example 9: Valrubicin 75% (W/W) Polyox 10 Hydroxypropylcellulose S
Croscarmellose sodium 10 Example 10: Tretinoin 6S% (W/W) Microcrystalline cellulose 20 Polyox 7.S
Croscarmellose sodium 7.S
Example 11: Tretinoin SS% (W/W) Microcrystalline cellulose 2S
Polyox 10 Glyceryl monooleate 10 Example 12: Tretinoin 7S% (W/t~
Polyox 10 Hydroxypropylcellulose S
Croscarmellose sodium 10 Enteric Release Component Formulate the ingredients by mixing the ingredients in a suitable pharmaceutical mixer or granulator such as a planetary mixer, high-shear granulator, fluid bed granulator, or extruder, in the presence of water or other solvent, or in a hot melt process. If water or other solvent was used, dry the blend in a suitable pharmaceutical drier, such as a vacuum over or forced-air oven. Allow the product to cool, the product may be sieved or granulated, and compressed using a suitable tablet press, such as a rotary tablet press.
In edient Conc. (% W/W) Example 13:
Acyclovir 65% (W/W) Microcrystalline cellulose 20 Cellulose Acetate Pthalate 15 Example 14:
Acyclovir 55% (W/W) Microcrystalline cellulose 25 Cellulose Acetate Pthalate 10 Hydroxypropylmethylcellulose 10 Example 15:
Acyclovir 65% (W/W) Polyox 20 Hydroxypropylcellulose pthalate 10 Eudragit L30D
Example 16:
Valacyclovir 80% (W/W) Lactose 10 Eudragit L 30D 10 Example 17:
Valacyclovir 70% (W/W) Polyethylene glycol 4000 20 Cellulose acetate pthalate 10 Example 18:
Ribavirin 60% (W/W) Polyethylene glycol 2000 10 Lactose 20 Eudragit L 30D 10 Example 19:
Ribavirin 70% (W/W) Microcrystalline cellulose 20 Cellulose acetate pthalate 10 Sustained Release Component Formulate the composition by mixing the ingredients in a suitable pharmaceutical mixer or granulator such as a planetary mixer, high-shear granulator, fluid bed granulator, or extruder, in the presence of water or other solvent, or in a hot melt process. If water or other solvent was used, dry the blend in a suitable pharmaceutical drier, such as a vacuum over or forced-air oven. Allow the product to cool, the product may be sieved or granulated, and compressed using a suitable tablet press, such as a rotary tablet press.
Ingredient Conc. (% W/W) Example 20:
Acyclovir 65% (W/W) Ethylcellulose 20 Polyox 10 Hydroxypropylmethylcellulose5 Example 21:
Acyclovir 55% (W/W) Lactose 25 Polyox 10 Glyceryl monooleate 10 Example 22:
Acyclovir 70% (W/V~
Polyox 20 Hydroxypropylcellulose 10 Example 23:
Zidovudine 75% (W/W) Lactose 15 Hydroxypropylcellulose 5 Ethylcellulose Example 24:
Zidovudine 75%
(W/W) Polyethylene glycol 4000 1~0 Lactose 10 Eudragit RL 30D
Example 25:
Zidovudine 80% (W/V~
Polyethylene glycol 8000 10 Hydroxypropylinethylcellulose 5 Eudgragit RS 30D 5 Example 26:
Example 27:
Valacyclovir 75% (W/W) Hydroxyethylcellulose 10 Polyethylene glycol 4000 IO
HydroxypropylceIIuIose 5 Valacyclovir 75% (W/W) Lactose 10 Povidone (PVP) 10 Polyethylene glycol 2000 5 Example 28:
Ribavirin 75% (W/W) Polyethylene glycol 4000 IO
Povidone (PVP) 10 Hydroxypropylcellulose S
Example 29:
Ribavirin 75% (W/W) Lactose 15 Polyethylene glycol 4000 5 Polyvinylpyrrolidone 5 Example 30:
Example 31:
Example 32:
Zidovudine 40% (W/W) Eudragit S 100 50 Triethyl Citrate 10 Zidovudine 50% (W/W) Sureteric 50 Zidovudine 50% (W/W) Eudragit S 100 45 Triethyl Citrate 5 All delayed release three pulses Example 33 Antiviral Pellet Formulation and Preparation Procedure Pellet Formulations The composition of the Antiviral pellets provided in Table 1.
Table x Composition of Antiviral Pellets Component Percentage (%) Antiviral drug 92 Avicel PH 101 6.0 Polyoxyl 35 Castor 1.0 Oil*
Hydroxypropyl methylcellulose, NF* 1.0 Purified Water **
Total 100 *Hydroxypropyl methylcellulose and Cremaphor EL
were added as a 2.9% w/w aqueous solution during wet massing.
*'~Removed during processing Preparation Procedure for Antiviral Pellets ~ Blend Antiviral and Avicel~ PH 1 O1 using a high shear mixer.
~ Add the hydroxypropyl methylcellulose and Polyoxyl 35 Castor Oil binder solution slowly into the powder blend under continuous mixing.
~ Extrude the wet mass using an LCI Bench Top Granulator. The diameter of the screen of the Bench Top Granulator is 0.8 mm.
~ Spheronize the extrudate using a QJ-230 Spheronizer using a small cross section plate.
~ Dry the spheronized pellets at 60°C using a fluid bed dryer until the exhaust temperature reaches 40°C.
~ Pellets between 20 and 40 Mesh were collected for further processing.
l~
Antiviral Pulse One Pellet Formulation and Preparation Procedure Preparation of an AOOAT AS-LF Aqueous Coating Dispersion Dispersion Formulation The composition of the aqueous AQOAT AS-LF aqueous coating dispersion applied to the Antiviral pellets is provided below in Table 2.
Table 2 AQOAT AS-LF Aqueous Coating Dispersion Component Percentage (%) AQOAT AS-LF 7.0 Triethyl Citrate 2.0 -Talc ~.1 Sodium lauryl sulfate Purified Water*
Solid Content 11.3 Polymer Content 7.0 Removed during processing Preparation Procedure for an AOOAT AS-LF Aaueous Dispersion Add triethyl citrate (TEC) to the purified water with stirring.
~ Add the sodium lauryl sulfate (SLS) to the TEC dispersion with stirring and completely until completely dissolved.
~ Add the AQOAT to the TEC/SLS dispersion and stir for at least 30 minutes.
~ Add the talc to the AQOAT dispersion and until completely mixed and for at least 30 minutes.
~ Screen the dispersion through a No. 60 mesh sieve prior to coating.
~ Continue to stir the dispersion until the coating process is complete.
Coating Conditions for the Application of AQOAT AS-LF Aaueous Coating Dispersion The following coating parameters were used for coating of the AQOAT AS-LF film coating dispersion.
Coating Equipment STREA 1T"" Table Top Laboratory Fluid Bed Coater Spray nozzle diameter 1.0 mm Material Charge 300 gram Inlet Air Temperature 48 °C
Outlet Air Temperature 27 °C
Atomization Air Pressure 1.6 Bar Pump Rate 3-4 gram per minute Coat Antiviral pellets with AQOAT AS-LF film coating dispersion such that you apply 30% coat weight gain to the pellets.
Antiviral Pulse Two Pellet Formulation and Preparation Procedure Preparation of an AQOAT AS-HF Adueous Coatin Dispersion Dispersion Formulation The composition of the aqueous AQOAT AS-HF aqueous coating dispersion applied to the Antiviral pellets is provided below in Table 3.
Table 3 AQOAT AS-HF Aqueous Coating Dispersion Component Percentage (%) AQOAT AS-HF 7.0 Triethyl Citrate 2.0 Talc 2.1 Sodium lauryl sulfate 0.2 Purified Water's 88.7 Solid Content 11.3 Polymer Content 7.0 ~Kemoved during processing Preparation Procedure for an AOOAT AS-HF Aqueous Dispersion ~ Add triethyl citrate (TEC) to the purified water with stirring.
~ Add the sodium lauryl sulfate (SLS) to the TEC dispersion with stirring and completely until completely dissolved.
~ Add the AQOAT to the TEC/SLS dispersion and stir for at least 30 minutes.
~ Add the talc to the AQOAT dispersion and until completely mixed and for at least 30 minutes.
~ Screen the dispersion through a No. 60 mesh sieve prior to coating.
Continue to stir the dispersion until the coating process is complete.
Coating Conditions for the Application of AQOAT AS-HF Aqueous Coating Dis ep rsion The following coating parameters were used for coating of the AQOAT AS-HF film coating dispersion.
Coating Equipment STREA 1T"" Table Top Laboratory Fluid Bed Coater Spray nozzle diameter 1.0 mm Material Charge 300 gram Inlet Air Temperature 48 °C
Outlet Air Temperature 27 °C
Atomization Air Pressure 1.6 Bar Pump Rate 3-4 gram per minute Coat Antiviral pellets with AQOAT AS-HF film coating dispersion such that you apply 30% coat weight gain to the pellets.
Antiviral Pulse Three Pellet Formulation and Preparation Procedure Preparation of an Eudra~it~ FS 30D Aqueous Coating Dispersion Dispersion Formulation The composition of the aqueous Eudragit~ FS 30D dispersion applied to the Antiviral pellets is provided below in Table 4.
Table 4 Eudragit~ FS 30D Aqueous Coating Dispersion Component Percentage (%) Eudragit~ FS 30D 54.8 Triethyl Citrate 0.9 Talc 3.3 Purified Water* 41.0 Solid Content 20.6 Polymer Content 16.4 *Removed during processing Preparation Procedure for an Eudra~it~ FS 30D Aaueous Dispersion Disperse triethyl citrate (TEC) in the purified water.
~ Add the talc in the triethyl citrate dispersion.
Homogenize the dispersion using a homogenizer.
Add slowly the Eudragit~ FS 30D dispersion to the talc/TEC dispersion with stirring.
Continue to stir the coating dispersion until the coating process is complete.
Coating Conditions for the Application of EudraQit FS30D Aaueous Coating Dispersion The following coating parameters were used for coating with each of the Eudragit~ FS
30 D aqueous film coating.
Coating Equipment STREA 1T"" Table Top Laboratory Fluid Bed Coater Spray nozzle diameter 1.2 mm Material Charge 300 gram Inlet Air Temperature 38 °C
Outlet Air Temperature 22 °C
Atomization Air Pressure 1.6 Bar Pump Rate 6 gram per minute Coat pellets with Eudragit FS 30D coating dispersion dispersion such that you apply 30%
coat weight gain to the pellets.
Antiviral Tablets Tabletin~Lof the Antiviral Pellets Table 5 Composition of Antiviral Tablets Component Percentage (%) Silicified microcrystalline cellulose21.6 Lactose monohydrate 13.0 Povidone 5.0 Pulse One Pellets 18.3 Pulse Two Pellets I8.3 Pulse Three Pellets 18.3 Croscarmellose sodium S.0 Magnesium stearate O.S
Total 100 ~ Slend the silicified microcrystalline cellulose, lactose monohydrate, povidone, colloidal silicon dioxide and Antiviral coated pellets for 1 S
minutes in a tumble blender.
~ Add the magnesium stearate to the blender, and blend for S minutes.
~ Compress the blend on a rotary tablet press.
~ The fill weight should be adjusted to achieve the desired dose.
Encapsulation of the Antiviral Pellets Pellets are filled into hard gelatin capsules at a ratio of 33.4%: 33.3%:
33.3%: Pulse One, Pulse Two, and Pulse Three Pellets respectively. The capsule is filled with the three different pellets to achieve the desired dose.
The present invention is particularly advantageous in that there is provided an antiviral product which provides an improvement over twice a day administration of the antiviral and an improvement over a once a day administration of the antiviral.
Numerous modification and variations of the present invention are possible in light of the above teachings and therefore, within the scope of the appended claims the invention may be practiced otherwise than as particularly described.
All delayed release four pulses Example 34 Antiviral Pellet Formulation and Preparation Procedure Pellet Formulations The composition of the Antiviral pellets provided in Table 6.
Table 6 Composition of Antiviral Pellets Component Percentage (%) Antiviral drug 92 Avicel PH 101 6.0 Polyoxyl 35 Castor 1.0 Oil*
Hydroxypropyl methylcellulose, NF* 1.0 Purified Water **
Total 100 *Hydroxypropyl methylcellulose and Cremaphor EL
were added as a 2.9% w/w aqueous solution during wet massing.
**Removed during processing Preparation Procedure for Antiviral Pellets ~ Blend Antiviral and Avicel~ PH 1 O1 using a high shear mixer.
~ Add the hydroxypropyl methylcellulose and Polyoxyl 35 Castor Oil binder solution slowly into the powder blend under continuous mixing.
~ Extrude the wet mass using an LCI Bench Top Granulator. The diameter of the screen of the Bench Top Granulator is 0.8 mm.
~ Spheronize the extrudate using a QJ-230 Spheronizer using a small cross section plate.
~ Dry the spheronized pellets at 60°C using a fluid bed dryer until the exhaust temperature reaches 40°C.
~ Pellets between 20 and 40 Mesh were collected for further processing.
Antiviral Pulse One Pellet Formulation and Preparation Procedure Preparation of an AQOAT AS-LF Aqueous Coating Dispersion Dispersion Formulation The composition of the aqueous AQOAT AS-LF aqueous coating dispersion applied to the Antiviral pellets is provided below in Table 7.
Table 7 AQOAT AS-LF Aqueous Coating Dispersion Component Percentage (%) AQOAT AS-LF 7.0 Triethyl Citrate 2.0 Talc 2.1 Sodium lauryl sulfate Purified Water*
Solid Content 11.3 Polymer Content 7.0 *Removed during processing Preparation Procedure for an AQOAT AS-LF Agueous Dispersion ~ Add triethyl citrate (TEC) to the purified water with stirring.
~ Add the sodium lauryl sulfate (SLS) to the TEC dispersion with stirring and completely until completely dissolved.
~ Add the AQOAT to the TEC/SLS dispersion and stir for at least 30 minutes.
~ Add the talc to the AQOAT dispersion and until completely mixed and for at least 30 minutes.
~ Screen the dispersion through a No. 60 mesh sieve prior to coating.
~ Continue to stir the dispersion until the coating process is complete.
Coatin~~Conditions for the Application of AQOAT AS-LF Aaueous Coating Disbersion The following coating parameters were used for coating of the AQOAT AS-LF film coating dispersion.
Coating Equipment STREA 1T"" Table Top Laboratory Fluid Bed Coater Spray nozzle diameter 1.0 mm Material Charge 300 gram Inlet Air Temperature 4~ °C
Outlet Air Temperature 27 °C
Atomization Air Pressure 1.6 Bar Pump Rate 3-4 gram per minute Coat Antiviral pellets with AQOAT AS-LF film coating dispersion such that you apply 30% coat weight gain to the pellets.
Antiviral Pulse Two Pellet Formulation and Preparation Procedure Preparation of an Eudra~it~ L 30 D-55 Aqueous Coating Dispersion Dispersion Formulation The composition of the aqueous Eudragit L30D-55 aqueous coating dispersion applied to the Antiviral pellets is provided below in Table 8.
Table 8 Eudragit~ L 30 D-55 Aqueous Coating Dispersion Component Percentage (%) Eudragit~ L 30D-55 44.4 Triethyl Citrate 1.3 Talc 6.7 Purified Water* 47.6 Solid Content 21.3 Polymer Content 13.3 *Removed during processing Preparation Procedure for an Eudra~it~ L 30D-55 Aaueous Dispersion ~ Disperse triethyl citrate (TEC) in the purified water.
~ Add the talc into the triethyl citrate dispersion.
~ Homogenize the dispersion using a homogenizer.
~ Add the TEC/talc dispersion to Eudragit L30D-55 latex dispersion and stir for at least 30 minutes.
~ Screen the dispersion through a No. 60 mesh sieve prior to coating.
~ Continue to stir the dispersion until the coating process is complete.
Coating Conditions for the Application of Eudra~it L30D-55 Aaueous Coating Dispersion The following coating parameters were used for coating of the Eudragit~ L 30 D-55 film coating dispersion.
Coating Equipment STREA 1T"~ Table Top Laboratory Fluid Bed Coater Spray nozzle diameter 1.0 mm Material Charge 300 gram Inlet Air Temperature 45 °C
Outlet Air Temperature 32 to 35 °C
Atomization Air Pressure 1.6 Bar Pump Rate 3-4 gram per minute Coat Antiviral pellets with Eudragit L30 D-55 film coating dispersion such that you apply 30% coat weight gain to the pellets.
Antiviral Pulse Three Pellets. Formulation and Preparation Procedure Preparation of an AQOAT AS-HF Aqueous Coating Dispersion Dispersion Formulation The composition of the aqueous AQOAT AS-HF aqueous coating dispersion applied to the Antiviral pellets is provided below in Table 9.
Table 9 AQOAT AS-HF Aqueous Coating Dispersion Component Percentage (%) AQOAT AS-HF 7.0 Triethyl Citrate 2.0 Talc 2.1 Sodium lauryl sulfate 0.2 Purified Water*
Solid Content 11.3 Polymer Content 7.0 Removed during processing Preparation Procedure for an AQOAT AS-HF Aaueous Dispersion Add triethyl citrate (TEC) to the purified water with stirring.
Add the sodium lauryl sulfate (SLS) to the TEC dispersion with stirnng and completely until completely dissolved.
Add the AQOAT to the TEC/SLS dispersion and stir for at least 30 minutes.
~ Add the talc to the AQOAT dispersion and until completely mixed and for at least 30 minutes.
~ Screen the dispersion through a No. 60 mesh sieve prior to coating.
~ Continue to stir the dispersion until the coating process is complete.
Coating Conditions for the Application of AOOAT AS-HF Aqueous Coating Dispersion The following coating parameters were used for coating of the AQOAT AS-HF film coating dispersion.
Coating Equipment STREA 1T"" Table Top Laboratory Fluid Bed Coater Spray nozzle diameter 1.0 mm Material Charge 300 gram Inlet Air Temperature 48 °C
Outlet Air Temperature 27 °C
Atomization Air Pressure 1.6 Bar Pump Rate 3-4 gram per minute Coat Antiviral pellets with AQOAT AS-HF film coating dispersion such that you apply 30% coat weight gain to the pellets.
Antiviral Pulse Four Pellet Formulation and Preparation Procedure Preparation of an Eudra~i.t~ FS 30D Aqueous Coating Dispersion Dispersion Formulation The composition of the aqueous Eudragit~ FS 30D dispersion applied to the Antiviral pellets is provided below in Table 10.
Table 10 Eudragit~ FS 30D Aqueous Coating Dispersion Component Percentage (%) Eudragit~ FS 30D 54.8 Triethyl Citrate 0.9 Talc 3.3 Purified Water* 41.0 Solid Content 20.6 Polymer Content 16.4 *Removed during processing Preparation Procedure for an Eudra~;it~ FS 30D Agueous Dispersion ~ Disperse triethyl citrate (TEC) in the purified water.
~ Add the talc in the triethyl citrate dispersion.
~ Homogenize the dispersion using a homogenizer.
~ Add slowly the Eudragit~ FS 30D dispersion to the talc/TEC dispersion with stirring.
Continue to stir the coating dispersion until the coating process is complete.
Coating Conditions for the Abplication of Eudra~it FS30D Aqueous Coating Dis ep rsion The following coating parameters were used for coating with each of the Eudragit~ FS
30 D aqueous film coating.
Coating Equipment STREA 1T"" Table Top Laboratory Fluid Bed Coater Spray nozzle diameter 1.2 mm Material Charge 300 gram Inlet Air Temperature 38 °C
Outlet Air Temperature 22 °C
Atomization Air Pressure 1.6 Bar Pump Rate 6 gram per minute Coat pellets with Eudragit FS 30D coating dispersion dispersion such that you apply 30%
coat weight gain to the pellets.
Antiviral Tablets Tabletin o~ f the Antiviral Pellets Table 11 Composition of Antiviral Tablets Component Percentage (%) Silicified microcrystalline cellulose21.5 Lactose monohydrate 13.0 Povidone 5.0 Pulse One Pellets 13.75 Pulse Two Pellets 13.75 Pulse Three Pellets 13.75 Pulse Four Pellets 13.75 Croscarmellose sodium S.0 Magnesium stearate 0.5 Total 100 ~ Blend the silicified microcrystalline cellulose, lactose monohydrate, povidone, colloidal silicon dioxide and Antiviral coated pellets for 15 minutes in a tumble blender.
~ Add the magnesium stearate to the blender, and blend for 5 minutes.
~ Compress the blend on a rotary tablet press.
~ The fill weight should be adjusted to achieve the desired dose.
Encapsulation of the Antiviral Pellets Pellets are filled into hard gelatin capsules at a ratio of 25%: 25%: 25%: 25%
Pulse One, Pulse Two, Pulse Three and Pulse Four Pellets respectively. The capsule is filled with the four different pellets to achieve the desired dose.
The present invention is particularly advantageous in that there is provided an antiviral product which provides an improvement over twice a day administration of the antiviral and an improvement over a once a day administration of the antiviral.
Numerous modification and variations of the present invention are possible in light of the above teachings and therefore, within the scope of the appended claims the invention may be practiced otherwise than as particularly described.
The present invention is particularly advantageous in that there is provided an mti-viral product which provides an improvement over twice a day administration of the anti-viral and an improvement over a once a day administration of the anti-viral.
Numerous modification and variations of the present invention are possible in light of the above teachings and therefore, within the scope of the appended claims the invention may be practiced otherwise than as particularly described.
Such "leakage" is not "release" as used herein.
If at least four 'dosage forms are used, the fourth of the at Ieast four dosage form may be a sustained release dosage form or a delayed release dosage form. If the fourth dosage form is a sustained release dosage form, even though Crn~ of the fourth dosage form of the at least four dosage forms is reached after the CmaX of each of the other dosage forms is reached, anti-viral release from such fourth dosage form may be initiated prior to or after release from the second or third dosage form.
The anti-viral product of the present invention, as hereinabove described, may be formulated for administration by a variety of routes of administration. For example, the anti-viral product may be formulated in a way that is suitable for topical administration;
administration in the eye or the ear; rectal or vaginal administration; as nose drops; by inhalation; as an injectable; or for oral administration. In a preferred embodiment, the anti-viral product is formulated in a manner such that it is suitable for oral administration.
For example, in formulating the anti-viral product for topical administration, such as by application to the skin, the at least two difFerent dosage forms, each of which contains an anti-viral, may be formulated for topical administration by including such dosage forms in an oil-in-water emulsion, or a water-in-oil emulsion. In such a formulation, the immediate release dosage form is in the continuous phase, and the delayed release dosage form is in a discontinuous phase. The formulation may also be produced in a manner for delivery of three dosage forms as hereinabove described. For example, there may be provided an oil-in-water-in-oil emulsion, with oil being a continuous phase that contains the immediate release component, water dispersed in the oil containing a first delayed release dosage form, and oil dispersed in the water containing a third delayed release dosage form.
It is also within the scope of the invention to provide an anti-viral product in the form of a patch, which includes anti-viral dosage forms having different release profiles, as hereinabove described.
In addition, the anti-viral product may be formulated fox use in the eye or ear or nose, for example, as a liquid emulsion. For example, the dosage form may be coated with a hydrophobic polymer whereby a dosage form is in the oil phase of the emulsion, and a dosage form may be coated with hydrophilic polymer, whereby a dosage form is in the water phase of the emulsion.
Furthermore, the anti-viral product with at least three different dosage forms with different release profiles may be formulated for rectal or vaginal administration, as known in the art. This may take the form of a cream or emulsion, or other dissolvable dosage form similar to those used for topical administration.
As a further embodiment, the anti-viral product may be formulated for use in inhalation therapy by coating the particles and micronizing the particles for inhalation.
In a preferred embodiment, the anti-viral product is formulated in a manner suitable for oral administration. Thus, for example, for oral administration, each of the dosage forms may be used as a pellet or a particle, with a pellet or particle then being formed into a unitary pharmaceutical product, for example, in a capsule, or embedded in a tablet, or suspended in a liquid for oral administration.
Alternatively, in formulating an oral delivery system, each of the dosage forms of the product may be formulated as a tablet, with each of the tablets being put into a capsule to produce a unitary anti-viral product. Thus, for example, anti-viral products may include a first dosage form in the form of a tablet that is an immediate release tablet, and may also include two or more additional tablets, each of which provides for a delayed release of the anti-viral, as hereinabove described, whereby the Cm~ of the anti-viral and where there are five delayed release components, the first delayed release component provides from ~ 0% to 25%, by weight, of the total anti-viral.
With respect to the delayed release components, where there are three delayed release components, the second delayed release component provides from 30% to 60%, by weight, of the total anti-viral provided by the second and third delayed release components with the third delayed release component providing the remainder of the anti-viral.
Where there are four delayed release components, the second released component provides 20% to 35% by weight of the total anti-viral provided by the second, third and fourth delayed release components, the next in time delayed release component provides from 20% to 40%, by weight, of the anti-viral provided by the second, third and fourth delayed release components and the last in time providing the remainder of the anti-viral provided by the second, third and fourth delayed release components.
When there are five delayed release components, the second delayed release component provides from 15% to 30%, by weight, the next in time delayed release component provides from 15% to 30%, the next in time delayed release component provides from 20% to 35%, by weight, and the last in time delayed release component provides from 20% to 35%, by weight, in each case of the total anti-viral provided by the second, third, fourth and fifth delayed release components.
An Immediate Release Component The immediate release portion of this system can be a mixture of ingredients that breaks down quicldy after administration to release the anti-viral. This can take the form of either a discrete pellet or granule that is mixed in with, or compressed with, the other three components.
released from each of the tablets is reached at different times, with the C~aX
of the total anti-viral released from the anti-viral product being achieved in less than twelve hours after anti-viral is first released.
The formulation of an anti-viral product including at least three dosage forms with different release profiles for different routes of administration is deemed to be within the skill of the art from the teachings herein. As known in the art, with respect to delayed release, the time of release can be controlled by the concentration of anti-virals in the coating and/or the thickness of the coating.
In formulating an anti-viral product in accordance with the invention, in one embodiment, the first dosage form of the product generally provides from about 20% to about 50% of the total dosage of anti-viral to be delivered by the product, with such first dosage form generally providing at least 25% of the total dosage of the anti-viral to be delivered by the product. In many cases, the first dosage form provides from about 20%
to about 30% of the total dosage of anti-viral to be delivered by the product;
however, in some cases it may be desirable to have the first dosage form provide for about 45% to about 50% of the total dosage of anti-viral to be delivered by the product.
The remaining dosage forms deliver the remainder of the anti-viral. In one embodiment, each of the delayed release dosage forms after the first delayed release dosage form may provide about equal amounts of anti-viral; however, they may also be formulated so as to provide different amounts.
In accordance with the present invention, each of the dosage fonns contains the same anti-viral; however, each of the dosage forms may contain more than one anti-viral.
Tn one embodiment, where the composition contains three delayed release components, the first component provides from 20% to 35% (preferably 20% to 30%), by weight, of the total anti-viral; where there is four delayed release components, the first delayed release component provides from 15% to 30%, by weight, of the total anti-viral;
The materials to be added to the anti-virals for the immediate release component can be, but are not limited to, microcrystalline cellulose, corn starch, pregelatinized starch, potato starch, rice starch, sodium carboxyrnethyl starch, hydroxypropylcellulose, hydroxypropylmethylcellulose, hydroxyethylcellulose, ethylcellulose, chitosan, hydroxychitosan, hydroxymethylatedchitosan, cross-Iinked chitosan, cross-linked hydroxymethyl chitosan, maltodextrin, mannitol, sorbitol, dextrose, maltose, fructose, glucose, levulose, sucrose, polyvinylpyrrolidone (PVP), acrylic acid derivatives (Carbopol, Eudragit, etc.), polyethylene glycols, such a low molecular weight PEGs (PEG2000-10000) and high molecular weight PEGS (Polyox) with molecular weights above 20,000 daltons.
It may be useful to have these materials present in the range of 1.0 to 60%
(W/W).
In addition, it may be useful to have other ingredients in this system to aid in the dissolution of the drug, or the breakdown of the component after ingestion or administration. These ingredients can be surfactants, such as sodium Iauryl sulfate, sodium monoglycerate, sorbitan monooleate, sorbitan monooleate, polyoxyethylene sorbitan monooleate, glyceryl monosteaxate, glyceryl monooleate, glyceryl monobutyrate, one of the non-ionic surfactants such as the Pluronic line of surfactants, or any other material with surface active properties, or any combination of the above.
These materials may be present in the rate of 0.05-15% (WlW).
~'he non-pH Sensitive Delayed Release Component The components in this composition are the same immediate release unit, but with additional polymers integrated into the composition, or as coatings over the pellet or granule.
Materials that can be used to obtain a delay in release suitable for this component of the invention can be, but are not limited to, polyethylene glycol (PEG) with molecular weight above 4,000 daltons (Carbowax, Polyox), waxes such as white wax or bees wax, paraffin, acrylic acid derivatives (Eudragit), propylene glycol, and ethylcellulose.
Typically these materials can be present in the range of 0.5-25% (W/W) of this component.
The pH Sensitive (Enteric) Release Component The components in this composition are the same as the immediate release component, but with additional polymers integrated into the composition, or as coatings over the pellet or granule.
The kind of materials useful for this purpose can be, but are not limited to, cellulose acetate pthalate, Eudragit L, and other pthalate salts of cellulose derivatives.
These materials can be present in concentrations from 4-20% (W/W).
Sustained Release Component The components in this composition are the same as the immediate release component, but with additional polymers integrated into the composition, or as coatings over the pellet or granule.
The kind of materials useful for this purpose can be, but are not limited to, ethylcellulose,hydroxypropylmethylcellulose,hydroxypropylcellulose, hydroxyethylcellulose, carboxymethylcellulose, methylcellulose, nitrocellulose, Eudragit R, and Eudragit RL, Carbopol, or polyethylene glycols with molecular weights in excess of 8,000 daltons.
These materials can be present in concentrations from 4-20% (WlW).
As hereinabove indicated, the units comprising the anti-viral composition of the present invention can be in the form of discrete pellets or particles contained in the capsule, or particles embedded in a tablet or suspended in a liquid suspension.
The anti-viral composition of the present invention may be administered, for example, by any of the following routes of administration: sublingual, transmucosal, transdermal, parenteral, etc., and preferably is administered orally. The composition includes a therapeutically effective amount of the anti-viral, which amount will vary with the anti-viral to be used, the disease or infection to be treated, and the number of times that the composition is to be delivered in a day. The composition is administered to a host in an amount effective for treating a bacterial infection.
The following are representative examples of some antivirals that may be used in the product of the invention: Acyclovir, Amantadine, Amprenavir, Cidofovir, Delavirdine, Didanosine, Famciclovir, Foscarnet, Ganciclovir, Indinavir, Interferon, Lamivudine, Nelfinavir, Nevirapine, Palivizumab, Penciclovir, Ribavirin, Rimantadine, Ritonavir, Saquinavir, Stavudine, Trifluridine, Valacyclovir, Vidarabine, Zalcitabine, Zidovudine The invention will be further described with respect to the following examples;
however, the scope of the invention is not limited thereby. All percentages in this specification, unless otherwise specified, are by weight.
A,ntiviral Examples non-pH Sensitive Delayed Release Component Formulate the composition by mixing the ingredients in a suitable pharmaceutical mixer or granulator such as a planetary mixer, high-shear granulator, fluid bed granulator, or extruder, in the presence of water or other solvent, or in a hot melt process. If water or other solvent was used, dry the blend in a suitable pharmaceutical drier, such as a vacuum over or forced-air oven. Allow the product to cool, the product may be sieved or granulated, and compressed using a suitable tablet press, such as a rotary tablet press.
In ear diem Conc. (% W/W) Example 1: Fluorouracil 65% (W/W) Microcxystalline cellulose 20 Polyox 7.5 Croscarmellose sodium 7.5 Example 2: Fluorouracil 55% (W/V~
Microcrystalline cellulose 25 Polyox 10 Glyceryl monooleate 10 Example 3: Fluorouracil 75% (W/W) Polyox 10 Hydroxypropylcellulose 5 Croscarmellose sodium 10 Example 4.: Dexamethasone 65% (W/W) Microcrystalline cellulose 20 Polyox 7.5 Croscarmellose sodium 7.5 Example 5: Dexamethasone 55% (W/W) Microcrystalline cellulose 25 Polyox 10 Glyceryl monooleate 10 Example 6: Dexamethasone 75% (W/W) Polyox 10 Hydroxypropylcellulose 5 Croscarmellose sodium 10 Example 7: Valrubicin 65% (W/W) Microcrystalline cellulose 20 Polyox 7. S
Croscarmellose sodium 7.S
Example 8: Valrubicin SS% (W/W) Microcrystalline cellulose 2S
Polyox 10 Glyceryl monooleate 10 Example 9: Valrubicin 75% (W/W) Polyox 10 Hydroxypropylcellulose S
Croscarmellose sodium 10 Example 10: Tretinoin 6S% (W/W) Microcrystalline cellulose 20 Polyox 7.S
Croscarmellose sodium 7.S
Example 11: Tretinoin SS% (W/W) Microcrystalline cellulose 2S
Polyox 10 Glyceryl monooleate 10 Example 12: Tretinoin 7S% (W/t~
Polyox 10 Hydroxypropylcellulose S
Croscarmellose sodium 10 Enteric Release Component Formulate the ingredients by mixing the ingredients in a suitable pharmaceutical mixer or granulator such as a planetary mixer, high-shear granulator, fluid bed granulator, or extruder, in the presence of water or other solvent, or in a hot melt process. If water or other solvent was used, dry the blend in a suitable pharmaceutical drier, such as a vacuum over or forced-air oven. Allow the product to cool, the product may be sieved or granulated, and compressed using a suitable tablet press, such as a rotary tablet press.
In edient Conc. (% W/W) Example 13:
Acyclovir 65% (W/W) Microcrystalline cellulose 20 Cellulose Acetate Pthalate 15 Example 14:
Acyclovir 55% (W/W) Microcrystalline cellulose 25 Cellulose Acetate Pthalate 10 Hydroxypropylmethylcellulose 10 Example 15:
Acyclovir 65% (W/W) Polyox 20 Hydroxypropylcellulose pthalate 10 Eudragit L30D
Example 16:
Valacyclovir 80% (W/W) Lactose 10 Eudragit L 30D 10 Example 17:
Valacyclovir 70% (W/W) Polyethylene glycol 4000 20 Cellulose acetate pthalate 10 Example 18:
Ribavirin 60% (W/W) Polyethylene glycol 2000 10 Lactose 20 Eudragit L 30D 10 Example 19:
Ribavirin 70% (W/W) Microcrystalline cellulose 20 Cellulose acetate pthalate 10 Sustained Release Component Formulate the composition by mixing the ingredients in a suitable pharmaceutical mixer or granulator such as a planetary mixer, high-shear granulator, fluid bed granulator, or extruder, in the presence of water or other solvent, or in a hot melt process. If water or other solvent was used, dry the blend in a suitable pharmaceutical drier, such as a vacuum over or forced-air oven. Allow the product to cool, the product may be sieved or granulated, and compressed using a suitable tablet press, such as a rotary tablet press.
Ingredient Conc. (% W/W) Example 20:
Acyclovir 65% (W/W) Ethylcellulose 20 Polyox 10 Hydroxypropylmethylcellulose5 Example 21:
Acyclovir 55% (W/W) Lactose 25 Polyox 10 Glyceryl monooleate 10 Example 22:
Acyclovir 70% (W/V~
Polyox 20 Hydroxypropylcellulose 10 Example 23:
Zidovudine 75% (W/W) Lactose 15 Hydroxypropylcellulose 5 Ethylcellulose Example 24:
Zidovudine 75%
(W/W) Polyethylene glycol 4000 1~0 Lactose 10 Eudragit RL 30D
Example 25:
Zidovudine 80% (W/V~
Polyethylene glycol 8000 10 Hydroxypropylinethylcellulose 5 Eudgragit RS 30D 5 Example 26:
Example 27:
Valacyclovir 75% (W/W) Hydroxyethylcellulose 10 Polyethylene glycol 4000 IO
HydroxypropylceIIuIose 5 Valacyclovir 75% (W/W) Lactose 10 Povidone (PVP) 10 Polyethylene glycol 2000 5 Example 28:
Ribavirin 75% (W/W) Polyethylene glycol 4000 IO
Povidone (PVP) 10 Hydroxypropylcellulose S
Example 29:
Ribavirin 75% (W/W) Lactose 15 Polyethylene glycol 4000 5 Polyvinylpyrrolidone 5 Example 30:
Example 31:
Example 32:
Zidovudine 40% (W/W) Eudragit S 100 50 Triethyl Citrate 10 Zidovudine 50% (W/W) Sureteric 50 Zidovudine 50% (W/W) Eudragit S 100 45 Triethyl Citrate 5 All delayed release three pulses Example 33 Antiviral Pellet Formulation and Preparation Procedure Pellet Formulations The composition of the Antiviral pellets provided in Table 1.
Table x Composition of Antiviral Pellets Component Percentage (%) Antiviral drug 92 Avicel PH 101 6.0 Polyoxyl 35 Castor 1.0 Oil*
Hydroxypropyl methylcellulose, NF* 1.0 Purified Water **
Total 100 *Hydroxypropyl methylcellulose and Cremaphor EL
were added as a 2.9% w/w aqueous solution during wet massing.
*'~Removed during processing Preparation Procedure for Antiviral Pellets ~ Blend Antiviral and Avicel~ PH 1 O1 using a high shear mixer.
~ Add the hydroxypropyl methylcellulose and Polyoxyl 35 Castor Oil binder solution slowly into the powder blend under continuous mixing.
~ Extrude the wet mass using an LCI Bench Top Granulator. The diameter of the screen of the Bench Top Granulator is 0.8 mm.
~ Spheronize the extrudate using a QJ-230 Spheronizer using a small cross section plate.
~ Dry the spheronized pellets at 60°C using a fluid bed dryer until the exhaust temperature reaches 40°C.
~ Pellets between 20 and 40 Mesh were collected for further processing.
l~
Antiviral Pulse One Pellet Formulation and Preparation Procedure Preparation of an AOOAT AS-LF Aqueous Coating Dispersion Dispersion Formulation The composition of the aqueous AQOAT AS-LF aqueous coating dispersion applied to the Antiviral pellets is provided below in Table 2.
Table 2 AQOAT AS-LF Aqueous Coating Dispersion Component Percentage (%) AQOAT AS-LF 7.0 Triethyl Citrate 2.0 -Talc ~.1 Sodium lauryl sulfate Purified Water*
Solid Content 11.3 Polymer Content 7.0 Removed during processing Preparation Procedure for an AOOAT AS-LF Aaueous Dispersion Add triethyl citrate (TEC) to the purified water with stirring.
~ Add the sodium lauryl sulfate (SLS) to the TEC dispersion with stirring and completely until completely dissolved.
~ Add the AQOAT to the TEC/SLS dispersion and stir for at least 30 minutes.
~ Add the talc to the AQOAT dispersion and until completely mixed and for at least 30 minutes.
~ Screen the dispersion through a No. 60 mesh sieve prior to coating.
~ Continue to stir the dispersion until the coating process is complete.
Coating Conditions for the Application of AQOAT AS-LF Aaueous Coating Dispersion The following coating parameters were used for coating of the AQOAT AS-LF film coating dispersion.
Coating Equipment STREA 1T"" Table Top Laboratory Fluid Bed Coater Spray nozzle diameter 1.0 mm Material Charge 300 gram Inlet Air Temperature 48 °C
Outlet Air Temperature 27 °C
Atomization Air Pressure 1.6 Bar Pump Rate 3-4 gram per minute Coat Antiviral pellets with AQOAT AS-LF film coating dispersion such that you apply 30% coat weight gain to the pellets.
Antiviral Pulse Two Pellet Formulation and Preparation Procedure Preparation of an AQOAT AS-HF Adueous Coatin Dispersion Dispersion Formulation The composition of the aqueous AQOAT AS-HF aqueous coating dispersion applied to the Antiviral pellets is provided below in Table 3.
Table 3 AQOAT AS-HF Aqueous Coating Dispersion Component Percentage (%) AQOAT AS-HF 7.0 Triethyl Citrate 2.0 Talc 2.1 Sodium lauryl sulfate 0.2 Purified Water's 88.7 Solid Content 11.3 Polymer Content 7.0 ~Kemoved during processing Preparation Procedure for an AOOAT AS-HF Aqueous Dispersion ~ Add triethyl citrate (TEC) to the purified water with stirring.
~ Add the sodium lauryl sulfate (SLS) to the TEC dispersion with stirring and completely until completely dissolved.
~ Add the AQOAT to the TEC/SLS dispersion and stir for at least 30 minutes.
~ Add the talc to the AQOAT dispersion and until completely mixed and for at least 30 minutes.
~ Screen the dispersion through a No. 60 mesh sieve prior to coating.
Continue to stir the dispersion until the coating process is complete.
Coating Conditions for the Application of AQOAT AS-HF Aqueous Coating Dis ep rsion The following coating parameters were used for coating of the AQOAT AS-HF film coating dispersion.
Coating Equipment STREA 1T"" Table Top Laboratory Fluid Bed Coater Spray nozzle diameter 1.0 mm Material Charge 300 gram Inlet Air Temperature 48 °C
Outlet Air Temperature 27 °C
Atomization Air Pressure 1.6 Bar Pump Rate 3-4 gram per minute Coat Antiviral pellets with AQOAT AS-HF film coating dispersion such that you apply 30% coat weight gain to the pellets.
Antiviral Pulse Three Pellet Formulation and Preparation Procedure Preparation of an Eudra~it~ FS 30D Aqueous Coating Dispersion Dispersion Formulation The composition of the aqueous Eudragit~ FS 30D dispersion applied to the Antiviral pellets is provided below in Table 4.
Table 4 Eudragit~ FS 30D Aqueous Coating Dispersion Component Percentage (%) Eudragit~ FS 30D 54.8 Triethyl Citrate 0.9 Talc 3.3 Purified Water* 41.0 Solid Content 20.6 Polymer Content 16.4 *Removed during processing Preparation Procedure for an Eudra~it~ FS 30D Aaueous Dispersion Disperse triethyl citrate (TEC) in the purified water.
~ Add the talc in the triethyl citrate dispersion.
Homogenize the dispersion using a homogenizer.
Add slowly the Eudragit~ FS 30D dispersion to the talc/TEC dispersion with stirring.
Continue to stir the coating dispersion until the coating process is complete.
Coating Conditions for the Application of EudraQit FS30D Aaueous Coating Dispersion The following coating parameters were used for coating with each of the Eudragit~ FS
30 D aqueous film coating.
Coating Equipment STREA 1T"" Table Top Laboratory Fluid Bed Coater Spray nozzle diameter 1.2 mm Material Charge 300 gram Inlet Air Temperature 38 °C
Outlet Air Temperature 22 °C
Atomization Air Pressure 1.6 Bar Pump Rate 6 gram per minute Coat pellets with Eudragit FS 30D coating dispersion dispersion such that you apply 30%
coat weight gain to the pellets.
Antiviral Tablets Tabletin~Lof the Antiviral Pellets Table 5 Composition of Antiviral Tablets Component Percentage (%) Silicified microcrystalline cellulose21.6 Lactose monohydrate 13.0 Povidone 5.0 Pulse One Pellets 18.3 Pulse Two Pellets I8.3 Pulse Three Pellets 18.3 Croscarmellose sodium S.0 Magnesium stearate O.S
Total 100 ~ Slend the silicified microcrystalline cellulose, lactose monohydrate, povidone, colloidal silicon dioxide and Antiviral coated pellets for 1 S
minutes in a tumble blender.
~ Add the magnesium stearate to the blender, and blend for S minutes.
~ Compress the blend on a rotary tablet press.
~ The fill weight should be adjusted to achieve the desired dose.
Encapsulation of the Antiviral Pellets Pellets are filled into hard gelatin capsules at a ratio of 33.4%: 33.3%:
33.3%: Pulse One, Pulse Two, and Pulse Three Pellets respectively. The capsule is filled with the three different pellets to achieve the desired dose.
The present invention is particularly advantageous in that there is provided an antiviral product which provides an improvement over twice a day administration of the antiviral and an improvement over a once a day administration of the antiviral.
Numerous modification and variations of the present invention are possible in light of the above teachings and therefore, within the scope of the appended claims the invention may be practiced otherwise than as particularly described.
All delayed release four pulses Example 34 Antiviral Pellet Formulation and Preparation Procedure Pellet Formulations The composition of the Antiviral pellets provided in Table 6.
Table 6 Composition of Antiviral Pellets Component Percentage (%) Antiviral drug 92 Avicel PH 101 6.0 Polyoxyl 35 Castor 1.0 Oil*
Hydroxypropyl methylcellulose, NF* 1.0 Purified Water **
Total 100 *Hydroxypropyl methylcellulose and Cremaphor EL
were added as a 2.9% w/w aqueous solution during wet massing.
**Removed during processing Preparation Procedure for Antiviral Pellets ~ Blend Antiviral and Avicel~ PH 1 O1 using a high shear mixer.
~ Add the hydroxypropyl methylcellulose and Polyoxyl 35 Castor Oil binder solution slowly into the powder blend under continuous mixing.
~ Extrude the wet mass using an LCI Bench Top Granulator. The diameter of the screen of the Bench Top Granulator is 0.8 mm.
~ Spheronize the extrudate using a QJ-230 Spheronizer using a small cross section plate.
~ Dry the spheronized pellets at 60°C using a fluid bed dryer until the exhaust temperature reaches 40°C.
~ Pellets between 20 and 40 Mesh were collected for further processing.
Antiviral Pulse One Pellet Formulation and Preparation Procedure Preparation of an AQOAT AS-LF Aqueous Coating Dispersion Dispersion Formulation The composition of the aqueous AQOAT AS-LF aqueous coating dispersion applied to the Antiviral pellets is provided below in Table 7.
Table 7 AQOAT AS-LF Aqueous Coating Dispersion Component Percentage (%) AQOAT AS-LF 7.0 Triethyl Citrate 2.0 Talc 2.1 Sodium lauryl sulfate Purified Water*
Solid Content 11.3 Polymer Content 7.0 *Removed during processing Preparation Procedure for an AQOAT AS-LF Agueous Dispersion ~ Add triethyl citrate (TEC) to the purified water with stirring.
~ Add the sodium lauryl sulfate (SLS) to the TEC dispersion with stirring and completely until completely dissolved.
~ Add the AQOAT to the TEC/SLS dispersion and stir for at least 30 minutes.
~ Add the talc to the AQOAT dispersion and until completely mixed and for at least 30 minutes.
~ Screen the dispersion through a No. 60 mesh sieve prior to coating.
~ Continue to stir the dispersion until the coating process is complete.
Coatin~~Conditions for the Application of AQOAT AS-LF Aaueous Coating Disbersion The following coating parameters were used for coating of the AQOAT AS-LF film coating dispersion.
Coating Equipment STREA 1T"" Table Top Laboratory Fluid Bed Coater Spray nozzle diameter 1.0 mm Material Charge 300 gram Inlet Air Temperature 4~ °C
Outlet Air Temperature 27 °C
Atomization Air Pressure 1.6 Bar Pump Rate 3-4 gram per minute Coat Antiviral pellets with AQOAT AS-LF film coating dispersion such that you apply 30% coat weight gain to the pellets.
Antiviral Pulse Two Pellet Formulation and Preparation Procedure Preparation of an Eudra~it~ L 30 D-55 Aqueous Coating Dispersion Dispersion Formulation The composition of the aqueous Eudragit L30D-55 aqueous coating dispersion applied to the Antiviral pellets is provided below in Table 8.
Table 8 Eudragit~ L 30 D-55 Aqueous Coating Dispersion Component Percentage (%) Eudragit~ L 30D-55 44.4 Triethyl Citrate 1.3 Talc 6.7 Purified Water* 47.6 Solid Content 21.3 Polymer Content 13.3 *Removed during processing Preparation Procedure for an Eudra~it~ L 30D-55 Aaueous Dispersion ~ Disperse triethyl citrate (TEC) in the purified water.
~ Add the talc into the triethyl citrate dispersion.
~ Homogenize the dispersion using a homogenizer.
~ Add the TEC/talc dispersion to Eudragit L30D-55 latex dispersion and stir for at least 30 minutes.
~ Screen the dispersion through a No. 60 mesh sieve prior to coating.
~ Continue to stir the dispersion until the coating process is complete.
Coating Conditions for the Application of Eudra~it L30D-55 Aaueous Coating Dispersion The following coating parameters were used for coating of the Eudragit~ L 30 D-55 film coating dispersion.
Coating Equipment STREA 1T"~ Table Top Laboratory Fluid Bed Coater Spray nozzle diameter 1.0 mm Material Charge 300 gram Inlet Air Temperature 45 °C
Outlet Air Temperature 32 to 35 °C
Atomization Air Pressure 1.6 Bar Pump Rate 3-4 gram per minute Coat Antiviral pellets with Eudragit L30 D-55 film coating dispersion such that you apply 30% coat weight gain to the pellets.
Antiviral Pulse Three Pellets. Formulation and Preparation Procedure Preparation of an AQOAT AS-HF Aqueous Coating Dispersion Dispersion Formulation The composition of the aqueous AQOAT AS-HF aqueous coating dispersion applied to the Antiviral pellets is provided below in Table 9.
Table 9 AQOAT AS-HF Aqueous Coating Dispersion Component Percentage (%) AQOAT AS-HF 7.0 Triethyl Citrate 2.0 Talc 2.1 Sodium lauryl sulfate 0.2 Purified Water*
Solid Content 11.3 Polymer Content 7.0 Removed during processing Preparation Procedure for an AQOAT AS-HF Aaueous Dispersion Add triethyl citrate (TEC) to the purified water with stirring.
Add the sodium lauryl sulfate (SLS) to the TEC dispersion with stirnng and completely until completely dissolved.
Add the AQOAT to the TEC/SLS dispersion and stir for at least 30 minutes.
~ Add the talc to the AQOAT dispersion and until completely mixed and for at least 30 minutes.
~ Screen the dispersion through a No. 60 mesh sieve prior to coating.
~ Continue to stir the dispersion until the coating process is complete.
Coating Conditions for the Application of AOOAT AS-HF Aqueous Coating Dispersion The following coating parameters were used for coating of the AQOAT AS-HF film coating dispersion.
Coating Equipment STREA 1T"" Table Top Laboratory Fluid Bed Coater Spray nozzle diameter 1.0 mm Material Charge 300 gram Inlet Air Temperature 48 °C
Outlet Air Temperature 27 °C
Atomization Air Pressure 1.6 Bar Pump Rate 3-4 gram per minute Coat Antiviral pellets with AQOAT AS-HF film coating dispersion such that you apply 30% coat weight gain to the pellets.
Antiviral Pulse Four Pellet Formulation and Preparation Procedure Preparation of an Eudra~i.t~ FS 30D Aqueous Coating Dispersion Dispersion Formulation The composition of the aqueous Eudragit~ FS 30D dispersion applied to the Antiviral pellets is provided below in Table 10.
Table 10 Eudragit~ FS 30D Aqueous Coating Dispersion Component Percentage (%) Eudragit~ FS 30D 54.8 Triethyl Citrate 0.9 Talc 3.3 Purified Water* 41.0 Solid Content 20.6 Polymer Content 16.4 *Removed during processing Preparation Procedure for an Eudra~;it~ FS 30D Agueous Dispersion ~ Disperse triethyl citrate (TEC) in the purified water.
~ Add the talc in the triethyl citrate dispersion.
~ Homogenize the dispersion using a homogenizer.
~ Add slowly the Eudragit~ FS 30D dispersion to the talc/TEC dispersion with stirring.
Continue to stir the coating dispersion until the coating process is complete.
Coating Conditions for the Abplication of Eudra~it FS30D Aqueous Coating Dis ep rsion The following coating parameters were used for coating with each of the Eudragit~ FS
30 D aqueous film coating.
Coating Equipment STREA 1T"" Table Top Laboratory Fluid Bed Coater Spray nozzle diameter 1.2 mm Material Charge 300 gram Inlet Air Temperature 38 °C
Outlet Air Temperature 22 °C
Atomization Air Pressure 1.6 Bar Pump Rate 6 gram per minute Coat pellets with Eudragit FS 30D coating dispersion dispersion such that you apply 30%
coat weight gain to the pellets.
Antiviral Tablets Tabletin o~ f the Antiviral Pellets Table 11 Composition of Antiviral Tablets Component Percentage (%) Silicified microcrystalline cellulose21.5 Lactose monohydrate 13.0 Povidone 5.0 Pulse One Pellets 13.75 Pulse Two Pellets 13.75 Pulse Three Pellets 13.75 Pulse Four Pellets 13.75 Croscarmellose sodium S.0 Magnesium stearate 0.5 Total 100 ~ Blend the silicified microcrystalline cellulose, lactose monohydrate, povidone, colloidal silicon dioxide and Antiviral coated pellets for 15 minutes in a tumble blender.
~ Add the magnesium stearate to the blender, and blend for 5 minutes.
~ Compress the blend on a rotary tablet press.
~ The fill weight should be adjusted to achieve the desired dose.
Encapsulation of the Antiviral Pellets Pellets are filled into hard gelatin capsules at a ratio of 25%: 25%: 25%: 25%
Pulse One, Pulse Two, Pulse Three and Pulse Four Pellets respectively. The capsule is filled with the four different pellets to achieve the desired dose.
The present invention is particularly advantageous in that there is provided an antiviral product which provides an improvement over twice a day administration of the antiviral and an improvement over a once a day administration of the antiviral.
Numerous modification and variations of the present invention are possible in light of the above teachings and therefore, within the scope of the appended claims the invention may be practiced otherwise than as particularly described.
The present invention is particularly advantageous in that there is provided an mti-viral product which provides an improvement over twice a day administration of the anti-viral and an improvement over a once a day administration of the anti-viral.
Numerous modification and variations of the present invention are possible in light of the above teachings and therefore, within the scope of the appended claims the invention may be practiced otherwise than as particularly described.
Claims (27)
1. ~An anti-viral product comprising: a first anti-viral dosage form, a second anti-viral dosage form, and a third anti-viral dosage form, each of said first, second and third anti-viral dosage forms comprising an anti-viral and a pharmaceutically acceptable carrier, said three dosage forms having different release profiles, said anti-viral product reaching a C max in less than about twelve hours after initial release of anti-viral and each being a delayed release dosage form.
2. ~The product of Claim 1 wherein the first dosage form is an immediate release dosage form.
3. ~The product of Claim 2 wherein the C max for the product is reached no earlier than four hours after initial release of anti-viral.
4. ~The product of Claim 2 wherein the first dosage form contains at least 20% and no more than 50% of the total dosage of anti-viral.
5. ~The product of Claim 4 wherein the product is an oral dosage form.
6. ~The product of Claim 5 wherein the anti-viral released from the second dosage form reaches a C max in the serum after C max is reached in the serum for anti-viral released from the first dosage form.
7. ~The product of Claim 6 wherein the anti-viral released from the third dosage form reaches a C max in the serum after the anti-viral released from the second dosage form reaches a C max in the serum.
8. ~The anti-viral product of Claim 1 wherein said anti-viral product includes a total dosage of anti-viral that is effective for a twenty four hour period.
9. ~The product of Claim 1 and further comprising a fourth anti-viral dosage form comprising an anti-viral and a pharmaceutically acceptable carrier, wherein anti-viral released from the fourth dosage form reaches a C max in the serum after C max is achieved in the serum for anti-viral released from each of the first, second and third dosage forms.
10. ~A process for treating a viral infection in a host comprising:
administering to a host the anti-viral product of Claim 1.
administering to a host the anti-viral product of Claim 1.
11. ~A process for treating a viral infection in a host comprising:
administering to a host the anti-viral product of Claim 2.
administering to a host the anti-viral product of Claim 2.
12. ~A process for treating a viral infection in a host comprising:
administering to a host the anti-viral product of Claim 3.
administering to a host the anti-viral product of Claim 3.
13. ~A process for treating a viral infection in a host comprising:
administering to a host the anti-viral product of Claim 4.
administering to a host the anti-viral product of Claim 4.
14. ~A process for treating a viral infection in a host comprising:
administering to a host the anti-viral product of Claim 5.
administering to a host the anti-viral product of Claim 5.
15. ~A process for treating a viral infection in a host comprising:
administering to a host the anti-viral product of Claim 6.
administering to a host the anti-viral product of Claim 6.
16. ~A process for treating a viral infection in a host comprising:
administering to a host the anti-viral product of Claim 7.
administering to a host the anti-viral product of Claim 7.
17. ~A process for treating a viral infection in a host comprising:
administering to a host the anti-viral product of Claim 8.
administering to a host the anti-viral product of Claim 8.
18. ~A process for treating a viral infection in a host comprising:
administering to a host the anti-viral product of Claim 9.
administering to a host the anti-viral product of Claim 9.
19. ~An anti-viral product comprising: a first anti-viral dosage form, a second anti-viral dosage form, and a third anti-viral dosage form, each of said first, second and third anti-viral dosage forms comprising an anti-viral and a pharmaceutically acceptable carrier, said three dosage forms having different release profiles, said anti-viral product reaching a C max in less than about twelve hours after initial release of anti-viral from the product, said first, second and third dosage forms, each being a delayed release dosage form, wherein the anti-viral released from the first dosage form reaches a C
max in serum in from 0.5 to 2 hours after initial release of anti-viral from the product, wherein the anti-viral released from the second dosage form reaches a C max in serum in no more than about 4 hours after initial release of anti-viral from the product and after C
max is reached for anti-viral from the first dosage form and the anti-viral released from the third dosage form reaches a C max in serum after the C max is reached for the anti-viral released from the second dosage form.
max in serum in from 0.5 to 2 hours after initial release of anti-viral from the product, wherein the anti-viral released from the second dosage form reaches a C max in serum in no more than about 4 hours after initial release of anti-viral from the product and after C
max is reached for anti-viral from the first dosage form and the anti-viral released from the third dosage form reaches a C max in serum after the C max is reached for the anti-viral released from the second dosage form.
20. ~The product of claim 19 wherein the second dosage form initiates release of the anti-viral at least one hour after the first dosage form.
21. ~The product of claim 20 wherein the C max for the second dosage form is reached no earlier than two hours after initial release of anti-viral from the product.
22. ~The product of claim 21 wherein the first dosage form contains from about 20% to about 50%, by weight, of the total anti-viral of the product, wherein the second dosage form contains from 30% to 60%, by weight, of the anti-viral that is contained in the second and third dosage forms.
23. ~The product of claim 22 wherein the first dosage form contains from 15%
to 30%, by weight, of the total anti-viral present in the product.
to 30%, by weight, of the total anti-viral present in the product.
24. ~The product of Claim 22 wherein the product includes a fourth delayed release anti-viral dosage form having a different release profile from the first, second and third dosage forms and C max for the fourth dosage form is reached after C max for each of the first, second and third dosage forms.
25. ~The product of claim 24 wherein the second dosage form contains from 20% to 35%, by weight, of the total anti-viral present in the second, third and fourth dosage forms, the third dosage form contains from 20% to 40%, by weight, of the total anti-viral present in the second, third and fourth dosage forms, with the remainder being present in the fourth dosage form.
26. ~The product of claim 19 wherein C max for the product is reached no earlier than four hours after initial release of anti-viral.
27. ~The product of claim 26 wherein C max in serum for the second dosage form is reached within 8 hours after initial release of anti-viral from the product.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US10/211,729 US7074417B2 (en) | 2000-10-13 | 2002-08-02 | Multiple-delayed release anti-viral product, use and formulation thereof |
| US10/211,729 | 2002-08-02 | ||
| PCT/US2003/024370 WO2004012713A1 (en) | 2002-08-02 | 2003-08-01 | Delayed release anti-viral product, use and formulation thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA2494017A1 true CA2494017A1 (en) | 2004-02-12 |
Family
ID=31494301
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002494017A Abandoned CA2494017A1 (en) | 2002-08-02 | 2003-08-01 | Delayed release anti-viral product, use and formulation thereof |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US7074417B2 (en) |
| EP (1) | EP1545465A4 (en) |
| JP (1) | JP2005538121A (en) |
| AU (1) | AU2003261359A1 (en) |
| CA (1) | CA2494017A1 (en) |
| WO (1) | WO2004012713A1 (en) |
Families Citing this family (28)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6991807B2 (en) * | 2000-02-24 | 2006-01-31 | Advancis Pharmaceutical, Corp. | Antibiotic composition |
| US6544555B2 (en) | 2000-02-24 | 2003-04-08 | Advancis Pharmaceutical Corp. | Antibiotic product, use and formulation thereof |
| US6541014B2 (en) * | 2000-10-13 | 2003-04-01 | Advancis Pharmaceutical Corp. | Antiviral product, use and formulation thereof |
| US20020068078A1 (en) | 2000-10-13 | 2002-06-06 | Rudnic Edward M. | Antifungal product, use and formulation thereof |
| US20020197314A1 (en) | 2001-02-23 | 2002-12-26 | Rudnic Edward M. | Anti-fungal composition |
| FR2830447B1 (en) * | 2001-10-09 | 2004-04-16 | Flamel Tech Sa | MICROPARTICULAR ORAL GALENIC FORM FOR DELAYED AND CONTROLLED RELEASE OF PHARMACEUTICAL ACTIVE INGREDIENTS |
| US8101209B2 (en) | 2001-10-09 | 2012-01-24 | Flamel Technologies | Microparticulate oral galenical form for the delayed and controlled release of pharmaceutical active principles |
| AU2003246792B2 (en) | 2002-04-09 | 2008-08-28 | Flamel Ireland Limited | Oral suspension of active principle microcapsules |
| IL164221A0 (en) * | 2002-04-09 | 2005-12-18 | Flamel Tech Sa | Oral pharmaceutical formulation in the form of aqueous suspension of microcapsules for modified release of amoxicillim |
| US20040114368A1 (en) * | 2002-12-13 | 2004-06-17 | Shyu Shing Jy | Light device having rotatable or movable view |
| CA2533178C (en) | 2003-07-21 | 2014-03-11 | Advancis Pharmaceutical Corporation | Antibiotic product, use and formulation thereof |
| CA2533358C (en) | 2003-07-21 | 2014-03-11 | Advancis Pharmaceutical Corporation | Antibiotic product, use and formulation thereof |
| US8313775B2 (en) | 2003-07-21 | 2012-11-20 | Shionogi Inc. | Antibiotic product, use and formulation thereof |
| CA2535177A1 (en) | 2003-08-11 | 2005-02-24 | Advancis Pharmaceutical Corporation | Robust pellet |
| US8062672B2 (en) | 2003-08-12 | 2011-11-22 | Shionogi Inc. | Antibiotic product, use and formulation thereof |
| AU2004270170B2 (en) | 2003-08-29 | 2011-01-27 | Shionogi, Inc. | Antibiotic product, use and formulation thereof |
| US8460710B2 (en) | 2003-09-15 | 2013-06-11 | Shionogi, Inc. | Antibiotic product, use and formulation thereof |
| US8715727B2 (en) | 2004-07-02 | 2014-05-06 | Shionogi Inc. | Tablet for pulsed delivery |
| CA2608505C (en) | 2005-05-18 | 2013-12-24 | Da Volterra | Colonic delivery of adsorbents |
| US20070166378A1 (en) * | 2005-06-09 | 2007-07-19 | Flamel Technologies, Inc. | Oral ribavirin pharmaceutical compositions |
| WO2006131790A2 (en) * | 2005-06-09 | 2006-12-14 | Flamel Technologies | Oral ribavirin pharmaceutical composition |
| US8357394B2 (en) | 2005-12-08 | 2013-01-22 | Shionogi Inc. | Compositions and methods for improved efficacy of penicillin-type antibiotics |
| US8778924B2 (en) | 2006-12-04 | 2014-07-15 | Shionogi Inc. | Modified release amoxicillin products |
| US8299052B2 (en) | 2006-05-05 | 2012-10-30 | Shionogi Inc. | Pharmaceutical compositions and methods for improved bacterial eradication |
| US8048413B2 (en) | 2006-05-17 | 2011-11-01 | Helene Huguet | Site-specific intestinal delivery of adsorbents, alone or in combination with degrading molecules |
| WO2010077061A2 (en) * | 2008-12-31 | 2010-07-08 | 한올바이오파마 주식회사 | Pharmaceutical formulations containing antiviral drugs |
| BRPI1007945C8 (en) | 2009-02-13 | 2021-05-25 | Romark Laboratories Lc | pharmaceutical formulation of controlled release of nitazoxanide, tizoxanide or a combination thereof, and bilayer tablet for oral administration |
| RU2676083C2 (en) | 2013-01-31 | 2018-12-26 | Портланд Стейт Юниверсити | Immunogenic compositions comprising silicified virus and methods of use |
Family Cites Families (42)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IL64009A (en) * | 1980-10-31 | 1984-09-30 | Rech Applications Therap | Crystalline 1,1-dioxopenicillanoyloxymethyl 6-(d-alpha-amino-alpha-phenylacetamido)penicillanate tosylate hydrates,their production and pharmaceutical compositions containing them |
| US4435173A (en) * | 1982-03-05 | 1984-03-06 | Delta Medical Industries | Variable rate syringe pump for insulin delivery |
| US4616008A (en) * | 1984-05-02 | 1986-10-07 | Takeda Chemical Industries, Ltd. | Antibacterial solid composition for oral administration |
| JPH0778017B2 (en) * | 1985-12-28 | 1995-08-23 | 住友製薬株式会社 | Pulsed and sustained release formulation |
| US4904476A (en) * | 1986-03-04 | 1990-02-27 | American Home Products Corporation | Formulations providing three distinct releases |
| US4794001A (en) * | 1986-03-04 | 1988-12-27 | American Home Products Corporation | Formulations providing three distinct releases |
| US5200193A (en) * | 1987-04-22 | 1993-04-06 | Mcneilab, Inc. | Pharmaceutical sustained release matrix and process |
| US5110597A (en) * | 1987-06-25 | 1992-05-05 | Alza Corporation | Multi-unit delivery system |
| US4915953A (en) * | 1987-09-03 | 1990-04-10 | Alza Corporation | Dosage form for delivering acetaminophen or phenylpropanolamine |
| US4971805A (en) * | 1987-12-23 | 1990-11-20 | Teysan Pharmaceuticals Co., Ltd. | Slow-releasing granules and long acting mixed granules comprising the same |
| US5133974A (en) * | 1989-05-05 | 1992-07-28 | Kv Pharmaceutical Company | Extended release pharmaceutical formulations |
| DK469989D0 (en) * | 1989-09-22 | 1989-09-22 | Bukh Meditec | PHARMACEUTICAL PREPARATION |
| US5229131A (en) * | 1990-02-05 | 1993-07-20 | University Of Michigan | Pulsatile drug delivery system |
| GB2253346A (en) * | 1991-02-22 | 1992-09-09 | John Rhodes | Delayed release oral dosage forms for treatment of intestinal disorders |
| US5260068A (en) * | 1992-05-04 | 1993-11-09 | Anda Sr Pharmaceuticals Inc. | Multiparticulate pulsatile drug delivery system |
| US5260069A (en) * | 1992-11-27 | 1993-11-09 | Anda Sr Pharmaceuticals Inc. | Pulsatile particles drug delivery system |
| US5414014A (en) * | 1993-04-08 | 1995-05-09 | Innova Biomed, Inc. | Methods for efficacious removal of attached, sucking antropods from human dermis |
| IL109770A0 (en) | 1993-05-29 | 1994-11-28 | Smithkline Beecham Corp | Thermal infusion process for preparing controlled release solid dosage forms of medicaments for oral administration and controlled release solid dosage forms of medicaments prepared thereby |
| EP0804174A4 (en) * | 1993-07-21 | 1998-09-09 | Univ Kentucky Res Found | A multicompartment hard capsule with control release properties |
| GB9402203D0 (en) | 1994-02-04 | 1994-03-30 | Smithkline Beecham Plc | Pharmaceutical formulation |
| US5395626A (en) * | 1994-03-23 | 1995-03-07 | Ortho Pharmaceutical Corporation | Multilayered controlled release pharmaceutical dosage form |
| GB9416600D0 (en) | 1994-08-17 | 1994-10-12 | Smithkline Beecham Plc | Pharmaceutical formulation |
| US5827531A (en) * | 1994-12-02 | 1998-10-27 | The United States Of America As Represented By The Administrator Of The National Aeronautics And Space Administration | Microcapsules and methods for making |
| US5567441A (en) * | 1995-03-24 | 1996-10-22 | Andrx Pharmaceuticals Inc. | Diltiazem controlled release formulation |
| MY115461A (en) * | 1995-03-30 | 2003-06-30 | Wellcome Found | Synergistic combinations of zidovudine, 1592u89 and 3tc |
| SE9600072D0 (en) * | 1996-01-08 | 1996-01-08 | Astra Ab | New oral formulation of two active ingredients II |
| US5719132A (en) * | 1996-06-27 | 1998-02-17 | Bristol-Myers Squibb Company | Compositions and methods of treating HIV with d4T, 5-fluorouracil/tegafur, and uracil |
| GB9622681D0 (en) * | 1996-10-31 | 1997-01-08 | Glaxo Group Ltd | Pharmaceutical compositions |
| IL119627A (en) | 1996-11-17 | 2002-03-10 | Yissum Res Dev Co | PHARMACEUTICAL PREPARATIONS FOR THE CONTROLLED-RELEASE OF AN ACTIVE AGENT COMPRISING AT LEAST ONE β-LACTAM ANTIBIOTIC AGENT |
| IT1289160B1 (en) * | 1997-01-08 | 1998-09-29 | Jagotec Ag | FULLY COATED PHARMACEUTICAL TABLET FOR THE CONTROLLED RELEASE OF ACTIVE INGREDIENTS WHICH PRESENT PROBLEMS OF |
| US6210710B1 (en) * | 1997-04-28 | 2001-04-03 | Hercules Incorporated | Sustained release polymer blend for pharmaceutical applications |
| US5877243A (en) * | 1997-05-05 | 1999-03-02 | Icet, Inc. | Encrustation and bacterial resistant coatings for medical applications |
| US5840329A (en) * | 1997-05-15 | 1998-11-24 | Bioadvances Llc | Pulsatile drug delivery system |
| GB9809213D0 (en) * | 1998-04-29 | 1998-07-01 | Glaxo Group Ltd | Pharmaceutical compositions |
| US6294199B1 (en) * | 1999-04-13 | 2001-09-25 | Beecham Pharmaceuticals (Pte) Limited | Method of treating a bacterial infection comprising administering amoxycillin |
| US20020004070A1 (en) * | 2000-02-24 | 2002-01-10 | Rudnic Edward M. | Antineoplastic product, use and formulation thereof |
| US6565882B2 (en) * | 2000-02-24 | 2003-05-20 | Advancis Pharmaceutical Corp | Antibiotic composition with inhibitor |
| US6544555B2 (en) * | 2000-02-24 | 2003-04-08 | Advancis Pharmaceutical Corp. | Antibiotic product, use and formulation thereof |
| AU2001239838A1 (en) * | 2000-02-24 | 2001-09-03 | Advancis Pharmaceutical Corporation | Therapeutic product, use and formulation thereof |
| EP1267765A4 (en) * | 2000-02-24 | 2008-12-24 | Middlebrook Pharmaceuticals In | Antibiotic and antifungal compositions |
| CA2447008A1 (en) * | 2001-04-05 | 2002-10-24 | Collagenex Pharmaceuticals, Inc. | Controlled delivery of tetracycline compounds and tetracycline derivatives |
| ZA200110500B (en) * | 2001-05-11 | 2002-04-03 | Cipla Medpro Pty Ltd | Pharmaceutical composition. |
-
2002
- 2002-08-02 US US10/211,729 patent/US7074417B2/en not_active Expired - Lifetime
-
2003
- 2003-08-01 WO PCT/US2003/024370 patent/WO2004012713A1/en active Application Filing
- 2003-08-01 AU AU2003261359A patent/AU2003261359A1/en not_active Abandoned
- 2003-08-01 CA CA002494017A patent/CA2494017A1/en not_active Abandoned
- 2003-08-01 JP JP2004526410A patent/JP2005538121A/en active Pending
- 2003-08-01 EP EP03767161A patent/EP1545465A4/en not_active Withdrawn
Also Published As
| Publication number | Publication date |
|---|---|
| US7074417B2 (en) | 2006-07-11 |
| WO2004012713A1 (en) | 2004-02-12 |
| AU2003261359A1 (en) | 2004-02-23 |
| US20030104056A1 (en) | 2003-06-05 |
| JP2005538121A (en) | 2005-12-15 |
| EP1545465A1 (en) | 2005-06-29 |
| EP1545465A4 (en) | 2009-10-28 |
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Legal Events
| Date | Code | Title | Description |
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| EEER | Examination request | ||
| FZDE | Discontinued |