CA2490544A1 - Minimally compliant, volume efficient piston for osmotic drug delivery systems - Google Patents

Minimally compliant, volume efficient piston for osmotic drug delivery systems Download PDF

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Publication number
CA2490544A1
CA2490544A1 CA002490544A CA2490544A CA2490544A1 CA 2490544 A1 CA2490544 A1 CA 2490544A1 CA 002490544 A CA002490544 A CA 002490544A CA 2490544 A CA2490544 A CA 2490544A CA 2490544 A1 CA2490544 A1 CA 2490544A1
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CA
Canada
Prior art keywords
piston
osmotic
agent
interior
delivery system
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA002490544A
Other languages
French (fr)
Other versions
CA2490544C (en
Inventor
Scott D. Lautenbach
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Intarcia Therapeutics Inc
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2490544A1 publication Critical patent/CA2490544A1/en
Application granted granted Critical
Publication of CA2490544C publication Critical patent/CA2490544C/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0002—Galenical forms characterised by the drug release technique; Application systems commanded by energy
    • A61K9/0004—Osmotic delivery systems; Sustained release driven by osmosis, thermal energy or gas
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M31/00—Devices for introducing or retaining media, e.g. remedies, in cavities of the body
    • A61M31/002—Devices for releasing a drug at a continuous and controlled rate for a prolonged period of time
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
    • A61M5/142—Pressure infusion, e.g. using pumps
    • A61M5/145—Pressure infusion, e.g. using pumps using pressurised reservoirs, e.g. pressurised by means of pistons
    • A61M2005/14513—Pressure infusion, e.g. using pumps using pressurised reservoirs, e.g. pressurised by means of pistons with secondary fluid driving or regulating the infusion

Abstract

An osmotic pump having a minimally compliant, volume efficient piston positioned within a capsule. The capsule has an interior surface, a benefici al agent, and an osmotic agent. The piston is movable with respect to an interi or surface of the capsule, and defines a movable seal with the interior surface of the capsule. The movable seal separates the osmotic agent from the beneficial agent. The piston has a length to total diameter ratio of about 1.1:1 and a core diameter to total diameter ratio of about 0.9:1. The piston enables greater beneficial agent and/or osmotic agent payload without increasing the size of the capsule. The osmotic agent imbibes liquid from a surrounding environment through a semipermeable body to cause the piston to move and in turn cause delivery of the beneficial agent from the capsule.</S DOAB>

Claims (16)

1. An osmotic delivery system comprising:
a capsule, said capsule having an interior for holding a beneficial agent, said interior having an interior surface;
an osmotic agent located in said interior;
a semipermeable body in liquid communication with said capsule for permitting liquid to permeate through said semipermeable body to said osmotic agent; and a piston having a length to total diameter ratio of about 1.1:1 and a core diameter to overall diameter ratio of about 0.9:1 located within said interior of said capsule, being movable with respect to said interior surface of said capsule, defining a movable seal with said interior surface of said capsule that separates said osmotic agent from the beneficial agent;
said osmotic agent located between said piston and said semipermeable body, said osmotic agent for imbibing fluid from a surrounding environment through said semipermeable body to cause said piston to move and in turn cause delivery of the beneficial agent from said capsule.
2. The osmotic delivery system according to Claim 1, wherein said piston includes one or a plurality of ribs for effecting said seal with said interior surface.
3. The osmotic delivery system according to Claim 1, wherein said capsule includes a cylindrical tube.
4. The osmotic delivery system according to Claim 3, wherein said cylindrical tube includes an opening and said semipermeable body includes a semipermeable plug, said semipermeable plug located within said opening.
5. The osmotic delivery system according to Claim 1, wherein said osmotic agent includes a tablet.
6. An osmotic delivery system comprising:

a piston having a length to overall diameter ratio of about 1.1:1 and a core diameter to overall diameter ratio of about 0.9:1;
an osmotic agent; and an enclosure having an interior holding said piston and said osmotic agent, said piston being movable with respect to said enclosure, and said enclosure having a semipermeable body in liquid communication with said osmotic agent for permitting liquid to permeate through said semipermeable body to said osmotic agent, said osmotic agent for imbibing fluid from a surrounding environment and causing said piston to move.
7. The osmotic delivery system according to Claim 6, wherein said interior of said enclosure includes an interior surface, said piston abutting against said interior surface.
8. The osmotic delivery system according to Claim 6, wherein said semipermeable body is located within said interior of said enclosure.
9. The osmotic delivery system according to Claim 6, wherein said enclosure is fluid impermeable.
10. The osmotic delivery system according to Claim 6, wherein said osmotic agent is located between said semipermeable body and said piston.
11. The osmotic delivery system according to Claim 6, further comprising a beneficial agent located in said interior of said enclosure, said beneficial agent being delivered from said enclosure when said piston moves.
12. The osmotic delivery system according to Claim 6, wherein said piston is fluid impermeable.
13. The osmotic delivery system according to Claim 6, wherein said piston includes at least one rib for effecting a movable seal with said enclosure.
14. The osmotic delivery system according to Claim 6, further comprising a beneficial agent located in said interior of said enclosure, said piston defining a movable seal that separates said osmotic agent from said beneficial agent.
15. An osmotic delivery system comprising:
a capsule having a tubular interior, said tubular interior having an interior surface;
a semipermeable body located at least partially within said tubular interior;
an osmotic agent located between said semipermeable body and said piston;
a beneficial agent located within said tubular interior; and a piston located within said tubular interior, said piston having a length to overall diameter ratio of about 1.1:1 and a core diameter to overall diameter ratio of about 0.9:1, said piston separating said beneficial agent from said osmotic agent, and being movable with respect to said interior surface of said tubular interior and with respect to said semipermeable body.
16. The osmotic delivery system according to Claim 15, wherein the piston includes at least one rib.
CA2490544A 2002-06-26 2003-06-25 Minimally compliant, volume efficient piston for osmotic drug delivery systems Expired - Fee Related CA2490544C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US39200402P 2002-06-26 2002-06-26
US60/392,004 2002-06-26
PCT/US2003/020130 WO2004002565A1 (en) 2002-06-26 2003-06-25 Minimally compliant, volume efficient piston for osmotic drug delivery systems

Publications (2)

Publication Number Publication Date
CA2490544A1 true CA2490544A1 (en) 2004-01-08
CA2490544C CA2490544C (en) 2011-04-19

Family

ID=30000792

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2490544A Expired - Fee Related CA2490544C (en) 2002-06-26 2003-06-25 Minimally compliant, volume efficient piston for osmotic drug delivery systems

Country Status (20)

Country Link
US (3) US6939556B2 (en)
EP (1) EP1551493B1 (en)
JP (1) JP4485945B2 (en)
KR (1) KR101046903B1 (en)
CN (1) CN100453130C (en)
AT (1) ATE376854T1 (en)
AU (1) AU2003256308B2 (en)
BR (1) BR0312429A (en)
CA (1) CA2490544C (en)
DE (1) DE60317225T2 (en)
EC (1) ECSP055578A (en)
ES (1) ES2295642T3 (en)
HK (1) HK1080402A1 (en)
IL (1) IL165975A (en)
MX (1) MXPA05000224A (en)
NO (1) NO20050368L (en)
NZ (1) NZ537628A (en)
TW (1) TW200531709A (en)
WO (1) WO2004002565A1 (en)
ZA (1) ZA200500744B (en)

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Also Published As

Publication number Publication date
WO2004002565A1 (en) 2004-01-08
CN100453130C (en) 2009-01-21
HK1080402A1 (en) 2006-04-28
KR101046903B1 (en) 2011-07-06
US7112335B2 (en) 2006-09-26
KR20050026416A (en) 2005-03-15
US20060111693A1 (en) 2006-05-25
TW200531709A (en) 2005-10-01
EP1551493A1 (en) 2005-07-13
MXPA05000224A (en) 2005-06-03
US20070088337A1 (en) 2007-04-19
NO20050368L (en) 2005-01-24
BR0312429A (en) 2005-04-19
US20040019345A1 (en) 2004-01-29
AU2003256308B2 (en) 2008-07-03
JP2005530588A (en) 2005-10-13
CA2490544C (en) 2011-04-19
US6939556B2 (en) 2005-09-06
ATE376854T1 (en) 2007-11-15
CN1671439A (en) 2005-09-21
AU2003256308A1 (en) 2004-01-19
ECSP055578A (en) 2005-04-18
IL165975A (en) 2009-07-20
ZA200500744B (en) 2006-03-29
JP4485945B2 (en) 2010-06-23
ES2295642T3 (en) 2008-04-16
DE60317225T2 (en) 2008-05-29
IL165975A0 (en) 2006-01-15
NZ537628A (en) 2005-12-23
DE60317225D1 (en) 2007-12-13
EP1551493B1 (en) 2007-10-31

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