CA2490233A1 - Bioactive agent release coating and controlled humidity method - Google Patents
Bioactive agent release coating and controlled humidity method Download PDFInfo
- Publication number
- CA2490233A1 CA2490233A1 CA002490233A CA2490233A CA2490233A1 CA 2490233 A1 CA2490233 A1 CA 2490233A1 CA 002490233 A CA002490233 A CA 002490233A CA 2490233 A CA2490233 A CA 2490233A CA 2490233 A1 CA2490233 A1 CA 2490233A1
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- Prior art keywords
- agents
- meth
- acrylates
- bioactive agent
- inhibitors
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
- A61L31/14—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
- A61L31/16—Biologically active materials, e.g. therapeutic substances
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L29/00—Materials for catheters, medical tubing, cannulae, or endoscopes or for coating catheters
- A61L29/08—Materials for coatings
- A61L29/085—Macromolecular materials
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L29/00—Materials for catheters, medical tubing, cannulae, or endoscopes or for coating catheters
- A61L29/14—Materials characterised by their function or physical properties, e.g. lubricating compositions
- A61L29/16—Biologically active materials, e.g. therapeutic substances
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
- A61L31/08—Materials for coatings
- A61L31/10—Macromolecular materials
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/60—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a special physical form
- A61L2300/602—Type of release, e.g. controlled, sustained, slow
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/60—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a special physical form
- A61L2300/606—Coatings
Abstract
A coating composition in the form of a one or multi-part system, and method of applying such a composition under conditions of controlled humidity, for use in coating device surfaces to control and/or improve their ability to release bioactive agents in aqueous systems. The coating composition is particularly adapted for use with medical devices that undergo significant flexion and/or expansion in the course of their delivery and/or use, such as stents and catheters. The composition includes the bioactive agent in combination with a first polymer component such as polyalkyl(meth)acrylate, polyaryl(meth)acrylate, polyaralkyl(meth)acrylate, or polyaryloxyalkyl(meth)acrylate and a second polymer component such as poly(ethylene-co-vinyl acetate).
Claims (40)
1. A method for controlling the rate of release of a bioactive agent from a coating composition provided in vivo, the method comprising the steps of:
a) providing a composition comprising a bioactive agent in combination with a plurality of polymers, including a first polymer component selected from the group consisting of polyalkyl(meth)acrylates and aromatic poly(meth)acrylates, and a second polymer component comprising poly(ethylene-co-vinyl acetate), and b) applying the coating composition under conditions of controlled humidity to provide a corresponding controlled bioactive agent release profile in vivo.
a) providing a composition comprising a bioactive agent in combination with a plurality of polymers, including a first polymer component selected from the group consisting of polyalkyl(meth)acrylates and aromatic poly(meth)acrylates, and a second polymer component comprising poly(ethylene-co-vinyl acetate), and b) applying the coating composition under conditions of controlled humidity to provide a corresponding controlled bioactive agent release profile in vivo.
2. A method according to claim 1 wherein the aromatic poly(meth)acrylates are selected from the group consisting polyalkyl(meth)acrylates, polyaryl(meth)acrylates, polyaralkyl(meth)acrylates, and polyaryloxyalkyl(meth)acrylates, and the coating is provided upon a surface of an implanted medical device and humidity is controlled either by controlling the humidity at which the device is coated with the composition and/or by controlling the water content of the coating or coated composition itself.
3. A method according to claim 1 wherein the coating is provided upon a surface of an implanted medical device and comprises a plurality of coating compositions, each independently coated under conditions of controlled humidity.
4. A method according to claim 2 wherein the device is one that undergoes flexion and/or expansion in the course of implantation or use in vivo.
5. A method according to claim 1 wherein the first polymer component is selected from the group consisting of:
a) polyalkyl(meth)acrylates with alkyl chain lengths from 2 to 8 carbons, b) polyaryl(meth)acrylates, polyaralkyl(meth)acrylates, and polyaryloxyalkyl(meth)acrylates with aryl groups having from 6 to 16 carbon atoms, the first polymer component having a weight average molecular weight of about 50 to about 900 kilodaltons.
a) polyalkyl(meth)acrylates with alkyl chain lengths from 2 to 8 carbons, b) polyaryl(meth)acrylates, polyaralkyl(meth)acrylates, and polyaryloxyalkyl(meth)acrylates with aryl groups having from 6 to 16 carbon atoms, the first polymer component having a weight average molecular weight of about 50 to about 900 kilodaltons.
6. A method according to claim 5 wherein the polyaryl(meth)acrylates are selected from the group consisting of poly-9-anthracenylmethacrylate, polychlorophenylacrylate, polymethacryloxy-2-hydroxybenzophenone, polynethacryloxybenzotriazole, polynaphthylacrylate, polynaphthylmethacrylate, poly-4-nitrophenylacrylate, polypentachloro(bromo, fluoro)acrylate and methacrylate, polyphenylacrylate and methacrylate, the polyaralkyl(meth)acrylates are selected from the group consisting of polybenzylacrylate and methacrylate, poly-2-phenethylacrylate and methacrylate, poly-1-pyrenylmethylmethacrylate, and the polyaryloxyalkyl(meth)acrylates are selected from the group consisting of polyphenoxyethylacrylate and methacrylate, polyethyleneglycolphenylether acrylates and methacrylates.
7. A method according to claim 2 wherein the composition is coated onto the device under relative humidity controlled at a level of between about 0 %
and about 95 % relative humidity.
and about 95 % relative humidity.
8. A method according to claim 5 wherein the second polymer component is selected from the group consisting of poly(ethylene-co-vinyl acetate) polymers having vinyl acetate concentrations of between about 8 % and about 90 by weight.
9. A method according to claim 8 wherein the vinyl acetate concentrations are between about 20 % and about 40 % by weight.
10. A method according to claim 1 wherein the composition is provided in a form selected from the group of solution, emulsion, mixture, dispersion or blend.
11. A method according to claim 10 wherein the total combined concentrations of both polymers in the composition is between about 0.05 % and about 70 % by weight.
12. A method according to claim 10 wherein the first polymeric component has a weight average molecular weight of from about 100 kilodaltons to about 500 kilodaltons and the poly(ethylene-co-vinyl acetate) has a vinyl acetate content of from about 20 % to about 40 % by weight.
13. A method according to claim 12 wherein the first polymeric component has a weight average molecular weight of from about 200 kilodaltons to about 400 kilodaltons and the poly(ethylene-co-vinyl acetate) has a vinyl acetate content of from about 30 % to about 34 % by weight.
14. A method according to claim 1 wherein the bioactive agent is dissolved or suspended in the coating composition at a concentration of about 0.01 %
to about 90 % by weight.
to about 90 % by weight.
15. A method according to claim 14 wherein the bioactive agent is selected from the group consisting of thrombin inhibitors, antithrombogenic agents, thrombolytic agents, fibrinolytic agents, vasospasm inhibitors, calcium channel blockers, vasodilators, antihypertensive agents, antimicrobial agents, antibiotics, inhibitors of surface glycoprotein receptors, antiplatelet agents, antimitotics, microtubule inhibitors, anti secretory agents, actin inhibitors, remodeling inhibitors, antisense nucleotides, anti metabolites, antiproliferatives, anticancer chemotherapeutic agents, anti-inflammatory steroid or non-steroidal anti-inflammatory agents, immunosuppressive agents, growth hormone antagonists, growth factors, dopamine agonists, radiotherapeutic agents, peptides, proteins, enzymes, extracellular matrix components, inhibitors, free radical scavengers, chelators, antioxidants, anti polymerases, antiviral agents, photodynamic therapy agents, and gene therapy agents.
16. A method according to claim 5 wherein the bioactive agent is dissolved or suspended in a coating composition having first and second polymer components at a total concentration of about 0.01 % to about 90 % by weight.
17. A method according to claim 16 wherein the bioactive agent is selected from the group consisting of thrombin inhibitors, antithrombogenic agents, thrombolytic agents, fibrinolytic agents, vasospasm inhibitors, calcium channel blockers, vasodilators, antihypertensive agents, antimicrobial agents, antibiotics, inhibitors of surface glycoprotein receptors, antiplatelet agents, antimitotics, microtubule inhibitors, anti secretory agents, actin inhibitors, remodeling inhibitors, antisense nucleotides, anti metabolites, antiproliferatives, anticancer chemotherapeutic agents, anti-inflammatory steroid or non-steroidal anti-inflammatory agents, immunosuppressive agents, growth hormone antagonists, growth factors, dopamine agonists, radiotherapeutic agents, peptides, proteins, enzymes, extracellular matrix components, inhibitors, free radical scavengers, chelators, antioxidants, anti polymerases, antiviral agents, photodynamic therapy agents, and gene therapy agents.
18. A method according to claim 8 wherein the bioactive agent is dissolved or suspended in the coating composition at a concentration of about 0.01 to about 90 % by weight.
19. A method according to claim 18 wherein the bioactive agent is selected from the group consisting of thrombin inhibitors, antithrombogenic agents, thrombolytic agents, fibrinolytic agents, vasospasm inhibitors, calcium channel blockers, vasodilators, antihypertensive agents, antimicrobial agents, antibiotics, inhibitors of surface glycoprotein receptors, antiplatelet agents, antimitotics, microtubule inhibitors, anti secretory agents, actin inhibitors, remodeling inhibitors, antisense nucleotides, anti metabolites, antiproliferatives, anticancer chemotherapeutic agents, anti-inflammatory steroid or non-steroidal anti-inflammatory agents, immunosuppressive agents, growth hormone antagonists, growth factors, dopamine agonists, radiotherapeutic agents, peptides, proteins, enzymes, extracellular matrix components, inhibitors, free radical scavengers, chelators, antioxidants, anti polymerases, antiviral agents, photodynamic therapy agents, and gene therapy agents.
20. A method according to claim 19 wherein the surface is provided by a device that comprises a catheter or stent.
21. A method for selecting an optimal bioactive agent release rate from a coated composition on a device to be positioned in vivo, the method comprising the steps of:
a) providing a composition comprising a bioactive agent in combination with a plurality of polymers, including a first polymer component comprising at least one polymer selected from the group consisting of polyalkyl(meth)acrylates, polyaryl(meth)acrylates, polyaralkyl(meth)acrylates, and polyaryloxyalkyl(meth)acrylates, and a second polymer component comprising poly(ethylene-co-vinyl acetate), and b) coating the composition on test device surfaces at a plurality of different humidity levels in order to provide corresponding release profiles, and evaluating the corresponding release profiles to determine a desired controlled humidity level.
a) providing a composition comprising a bioactive agent in combination with a plurality of polymers, including a first polymer component comprising at least one polymer selected from the group consisting of polyalkyl(meth)acrylates, polyaryl(meth)acrylates, polyaralkyl(meth)acrylates, and polyaryloxyalkyl(meth)acrylates, and a second polymer component comprising poly(ethylene-co-vinyl acetate), and b) coating the composition on test device surfaces at a plurality of different humidity levels in order to provide corresponding release profiles, and evaluating the corresponding release profiles to determine a desired controlled humidity level.
22. A combination comprising a device coated with a composition according to the method of claim 1, the combination being adapted to provide controlled release of the bioactive agent when positioned in an aqueous environment.
23. A combination according to claim 22 wherein the device is an implantable medical device that that undergoes flexion and/or expansion in the course of implantation or use in vivo, and the surface is coated with a plurality of coating compositions, each independently coated under conditions of controlled humidity.
24. A combination according to claim 22 wherein the first polymer component is selected from the group consisting of:
a) polyalkyl(meth)acrylates with alkyl chain lengths from 2 to 8 carbons, b) polyaryl(meth)acrylates, polyaralkyl(meth)acrylates, and polyaryloxyalkyl(meth)acrylates with aryl groups having from 6 to 16 carbon atoms, the first polymer component having a weight average molecular weight of about 50 to about 900 kilodaltons, and the second polymer component is selected from the group consisting of polyethylene-co-vinyl acetate) polymers having vinyl acetate concentrations of between about 8 % and about 90 % by weight.
a) polyalkyl(meth)acrylates with alkyl chain lengths from 2 to 8 carbons, b) polyaryl(meth)acrylates, polyaralkyl(meth)acrylates, and polyaryloxyalkyl(meth)acrylates with aryl groups having from 6 to 16 carbon atoms, the first polymer component having a weight average molecular weight of about 50 to about 900 kilodaltons, and the second polymer component is selected from the group consisting of polyethylene-co-vinyl acetate) polymers having vinyl acetate concentrations of between about 8 % and about 90 % by weight.
25. A combination according to claim 22 wherein the coating is provided by a coating composition in the form of a one part system comprising bioactive agent, and first and second polymer components, and the total combined concentrations of both polymers in the coating composition is between about 0.05% and about 70%
by weight, and the bioactive agent is dissolved or suspended in the coating composition at a concentration of about 0.01 % to about 90 % by weight.
by weight, and the bioactive agent is dissolved or suspended in the coating composition at a concentration of about 0.01 % to about 90 % by weight.
26. A combination according to claim 25 wherein the total combined concentrations of both polymers in the coating composition is between about 0.25 and about 10 % by weight.
27. A combination according to claim 23 wherein the device is selected from the group consisting of catheters and stents.
28. A combination according to claim 27 wherein the catheter is selected from the group consisting of urinary catheters and intravenous catheters.
29. A combination according to claim 22 wherein the weight of the coating attributable to the bioactive agent is in the range of about one microgram to about 10 mg of bioactive agent per cm2 of the gross surface area of the device.
30. A combination according to claim 29 wherein the weight of the coating attributable to the bioactive agent is between about 0.01 mg and about 0.5 mg of bioactive agent per cm2 of the gross surface area of the device, and the coating thickness of the composition is in the range of about 0.1 micrometers to about micrometers.
31. A method of using a combination of claim 23, the method comprising the steps of a) implanting the device in vivo under conditions in which the device undergoes flexion or expansion by being bent by at least 45 degrees or more and/or expanded to more than twice its initial dimension, either in the course of its placement, or thereafter in the course of its use in vivo, and b) permitting the device to remain implanted and to release the bioactive agent in situ.
32. A method according to claim 31 wherein the first polymer component is selected from the group consisting of a) polyalkyl(meth)acrylates with alkyl chain lengths from 2 to 8 carbons, b) polyaryl(meth)acrylates, polyaralkyl(meth)acrylates, and polyaryloxyalkyl(meth)acrylates with aryl groups having from 6 to 16 carbon atoms, the first polymer component having a weight average molecular weight of about 50 to about 900 kilodaltons, and the second polymer component is selected from the group consisting of poly(ethylene-co-vinyl acetate) polymers having vinyl acetate concentrations of between about 8 % and about 90 % by weight.
33. A method according to claim 32 wherein the weight of the coating attributable to the bioactive agent is between about 0.01 mg and about 0.5 mg of bioactive agent per cm2 of the gross surface area of the device, and the coating thickness of the composition is in the range of about 0.1 micrometers to about micrometers.
34. A method according to claim 33 wherein the device is selected from the group consisting of catheters and stents.
35. A system comprising a coated device combination according to claim 22 positioned in situ within a body.
36 A method according to one of claims 1, 15, 21, or 31 wherein the composition further comprises a solvent in which the polymers form a true solution.
37. A method according to one of claims 1, 15, 21, or 31 wherein the device comprises a biomaterial selected from the group consisting of acrylics, vinyls, nylons, polyurethanes, polycarbonates, polyamides, polysulfones, polyethylene terephthalate), polylactic acid, polyglycolic acid, polydimethylsiloxanes, and polyetheretherketones, natural organic materials, metals, ceramics, glass, silica, and sapphire.
38. A method according to claim 37 wherein the acrylics axe selected from methyl acrylate, methyl methacrylate, hydroxyethyl methacrylate, hydroxyethyl acrylate, acrylic acid, methacrylic acid, glyceryl acrylate, glyceryl methacrylate, methacrylamide, and acrylamide, the vinyls are selected from ethylene, propylene, styrene, vinyl chloride, vinyl acetate, vinyl pyrrolidone, and vinylidene difluoride, the nylons are selected from polycaprolactam, polylauryl lactam, polyhexamethylene adipamide, and polyhexamethylene dodecanediamide, the organic materials are selected from human tissue, wood, cellulose, compressed carbon, and rubber, the metals are selected from titanium, stainless steel, cobalt chromium, gold, silver, copper, and platinum and their alloys, and the ceramics are selected from silicon nitride, silicon carbide, zirconia, and alumina, including combinations of such biomaterials.
39. A method according to one of claims 1, 15, 21, or 31 wherein the device is selected from the group consisting of vascular devices, orthopedic devices, dental devices, drug delivery devices, ophthalmic devices, glaucoma drain shunts, urological devices, synthetic prostheses, dialysis tubing and membranes, blood oxygenator tubing and membranes, blood bags, sutures, membranes, cell culture devices, chromatographic support materials, and biosensors.
40. A method according to claim 39 wherein the vascular devices are selected from grafts, stems, catheters, valves, artificial hearts, and heart assist devices, the orthopedic devices are selected from joint implants, fracture repair devices, and artificial tendons, the dental devices are selected from dental implants and fracture repair devices, and the urological devices are selected from penile, sphincter, urethral, bladder, and renal devices.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US10/175,210 US7097850B2 (en) | 2002-06-18 | 2002-06-18 | Bioactive agent release coating and controlled humidity method |
US10/175,210 | 2002-06-18 | ||
PCT/US2003/019107 WO2003105919A1 (en) | 2002-06-18 | 2003-06-18 | Bioactive agent release coating and controlled humidity method |
Publications (2)
Publication Number | Publication Date |
---|---|
CA2490233A1 true CA2490233A1 (en) | 2003-12-24 |
CA2490233C CA2490233C (en) | 2011-10-25 |
Family
ID=29733804
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CA2490233A Expired - Fee Related CA2490233C (en) | 2002-06-18 | 2003-06-18 | Bioactive agent release coating and controlled humidity method |
Country Status (8)
Country | Link |
---|---|
US (3) | US7097850B2 (en) |
EP (1) | EP1517714B1 (en) |
JP (2) | JP4008921B2 (en) |
AT (1) | ATE437665T1 (en) |
AU (1) | AU2003245547A1 (en) |
CA (1) | CA2490233C (en) |
DE (1) | DE60328607D1 (en) |
WO (1) | WO2003105919A1 (en) |
Families Citing this family (60)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US8685427B2 (en) * | 2002-07-31 | 2014-04-01 | Boston Scientific Scimed, Inc. | Controlled drug delivery |
US7097850B2 (en) * | 2002-06-18 | 2006-08-29 | Surmodics, Inc. | Bioactive agent release coating and controlled humidity method |
US7169178B1 (en) * | 2002-11-12 | 2007-01-30 | Advanced Cardiovascular Systems, Inc. | Stent with drug coating |
MXPA05010388A (en) * | 2003-03-28 | 2006-03-08 | Kosan Biosciences Inc | Devices, methods, and compositions to prevent restenosis. |
EP1633320A2 (en) | 2003-05-02 | 2006-03-15 | SurModics, Inc. | Implantable controlled release bioactive agent delivery device |
US8246974B2 (en) | 2003-05-02 | 2012-08-21 | Surmodics, Inc. | Medical devices and methods for producing the same |
US20050129731A1 (en) * | 2003-11-03 | 2005-06-16 | Roland Horres | Biocompatible, biostable coating of medical surfaces |
US8137397B2 (en) * | 2004-02-26 | 2012-03-20 | Boston Scientific Scimed, Inc. | Medical devices |
US20050281857A1 (en) * | 2004-05-25 | 2005-12-22 | Heyer Toni M | Methods and reagents for preparing biomolecule-containing coatings |
US20050266043A1 (en) * | 2004-05-27 | 2005-12-01 | Medtronic Vascular, Inc. | Methods and compounds for treatment of aneurysmal tissue |
PT1781264E (en) | 2004-08-04 | 2013-10-16 | Evonik Corp | Methods for manufacturing delivery devices and devices thereof |
US8246569B1 (en) * | 2004-08-17 | 2012-08-21 | California Institute Of Technology | Implantable intraocular pressure drain |
US7709049B2 (en) * | 2004-09-10 | 2010-05-04 | Surmodics, Inc. | Methods, devices, and coatings for controlled active agent release |
EP1819373A2 (en) | 2004-12-07 | 2007-08-22 | SurModics, Inc. | Coatings with crystallized active agent(s) |
JP2008535563A (en) * | 2005-04-06 | 2008-09-04 | サーモディクス,インコーポレイティド | Coating composition for bioactive agents |
EP1888001B1 (en) * | 2005-06-10 | 2014-08-06 | Syneron Medical Ltd. | Patch for transdermal drug delivery |
US20080009500A1 (en) * | 2005-11-08 | 2008-01-10 | Michael Kahn | Alpha-helix mimetics and methods relating to the treatment of fibrotic disorders |
US7829148B2 (en) * | 2006-02-07 | 2010-11-09 | Fmc Corporation | Coating process to produce controlled release coatings |
US20080124372A1 (en) * | 2006-06-06 | 2008-05-29 | Hossainy Syed F A | Morphology profiles for control of agent release rates from polymer matrices |
US9259535B2 (en) | 2006-06-22 | 2016-02-16 | Excelsior Medical Corporation | Antiseptic cap equipped syringe |
US11229746B2 (en) | 2006-06-22 | 2022-01-25 | Excelsior Medical Corporation | Antiseptic cap |
US8685421B2 (en) | 2006-07-07 | 2014-04-01 | Surmodics, Inc. | Beaded wound spacer device |
CA2667000A1 (en) * | 2006-09-25 | 2008-04-03 | James P. Murphy | Bioactive load-bearing composites comprising peek and bioglass particles |
JP5612474B2 (en) * | 2007-10-17 | 2014-10-22 | トランスファーマ メディカル リミテッド | Verification of dissolution rate |
JP5508272B2 (en) * | 2007-10-29 | 2014-05-28 | トランスファーマ メディカル リミテッド | Vertical patch drying |
US8728528B2 (en) | 2007-12-20 | 2014-05-20 | Evonik Corporation | Process for preparing microparticles having a low residual solvent volume |
DE102008034826A1 (en) * | 2008-07-22 | 2010-01-28 | Alexander Rübben | A method of creating a bioactive surface on the balloon of a balloon catheter |
US8622995B2 (en) | 2009-10-26 | 2014-01-07 | Pursuit Vascular, Inc. | Method for delivery of antimicrobial to proximal end of catheter |
US8622996B2 (en) | 2008-10-27 | 2014-01-07 | Pursuit Vascular, Inc. | Method for applying antimicrobial to proximal end of catheter |
US9022984B2 (en) | 2008-10-27 | 2015-05-05 | Pursuit Vascular, Inc. | Apparatus for delivery of device and antimicrobial agent into trans-dermal catheter |
US9078992B2 (en) | 2008-10-27 | 2015-07-14 | Pursuit Vascular, Inc. | Medical device for applying antimicrobial to proximal end of catheter |
US20100168798A1 (en) | 2008-12-30 | 2010-07-01 | Clineff Theodore D | Bioactive composites of polymer and glass and method for making same |
US8529492B2 (en) | 2009-12-23 | 2013-09-10 | Trascend Medical, Inc. | Drug delivery devices and methods |
CN102905562A (en) | 2010-05-20 | 2013-01-30 | 艺康美国股份有限公司 | Rheology modified low foaming liquid antimicrobial compositions and methods of use thereof |
CN103517904A (en) | 2011-02-25 | 2014-01-15 | 株式会社棱镜制药 | Alpha helix mimetics and methods relating thereto |
CA2841832C (en) | 2011-07-12 | 2019-06-04 | Pursuit Vascular, Inc. | Device for delivery of antimicrobial agent into a trans-dermal catheter |
US9386772B2 (en) * | 2012-02-14 | 2016-07-12 | Allegiance Corporation | Antimicrobial elastomeric articles |
MX351261B (en) | 2012-06-01 | 2017-10-06 | Surmodics Inc | Apparatus and method for coating balloon catheters. |
US9827401B2 (en) | 2012-06-01 | 2017-11-28 | Surmodics, Inc. | Apparatus and methods for coating medical devices |
WO2014062839A1 (en) | 2012-10-16 | 2014-04-24 | Surmodics, Inc. | Wound packing device and methods |
DE102013215912B3 (en) * | 2013-08-12 | 2015-02-26 | Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. | Color-neutral coated copper-containing article, process for its preparation and use of a corresponding color-neutral coating |
DE102013215919B3 (en) * | 2013-08-12 | 2015-02-05 | Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. | Color-neutral coated metal-containing article with metal-containing or metal surface, process for its preparation and use of a corresponding color-neutral coating |
US10201457B2 (en) | 2014-08-01 | 2019-02-12 | Surmodics, Inc. | Wound packing device with nanotextured surface |
AU2016243634B2 (en) | 2015-03-30 | 2020-04-02 | C. R. Bard, Inc. | Application of antimicrobial agents to medical devices |
EP3294404A4 (en) | 2015-05-08 | 2018-11-14 | ICU Medical, Inc. | Medical connectors configured to receive emitters of therapeutic agents |
EP3525865B1 (en) | 2016-10-14 | 2022-10-12 | ICU Medical, Inc. | Sanitizing caps for medical connectors |
WO2018204206A2 (en) | 2017-05-01 | 2018-11-08 | Icu Medical, Inc. | Medical fluid connectors and methods for providing additives in medical fluid lines |
BR112020023983A2 (en) | 2018-05-24 | 2021-02-23 | Celanese Eva Performance Polymers Llc | implantable device for prolonged release of a macromolecular drug compound |
MX2020012459A (en) | 2018-05-24 | 2021-04-28 | Celanese Eva Performance Polymers Llc | Implantable device for sustained release of a macromolecular drug compound. |
CN215915829U (en) | 2018-07-02 | 2022-03-01 | C·R·巴德股份有限公司 | Antimicrobial catheter assembly |
SG11202101878QA (en) | 2018-09-21 | 2021-03-30 | Univ Delaware | Piezoelectric sensors comprising electrospun poly [(r)-3-hydroxybutyrate-co-(r)-3-hydroxyhexanoate] (phbhx) nanofibers |
US11400195B2 (en) | 2018-11-07 | 2022-08-02 | Icu Medical, Inc. | Peritoneal dialysis transfer set with antimicrobial properties |
US11541221B2 (en) | 2018-11-07 | 2023-01-03 | Icu Medical, Inc. | Tubing set with antimicrobial properties |
US11534595B2 (en) | 2018-11-07 | 2022-12-27 | Icu Medical, Inc. | Device for delivering an antimicrobial composition into an infusion device |
US11541220B2 (en) | 2018-11-07 | 2023-01-03 | Icu Medical, Inc. | Needleless connector with antimicrobial properties |
US11517732B2 (en) | 2018-11-07 | 2022-12-06 | Icu Medical, Inc. | Syringe with antimicrobial properties |
US10525250B1 (en) | 2018-11-07 | 2020-01-07 | Pursuit Vascular, Inc. | Infusion device with antimicrobial properties |
WO2020106985A1 (en) | 2018-11-21 | 2020-05-28 | Pursuit Vascular, Inc. | Antimicrobial device comprising a cap with ring and insert |
US11628466B2 (en) | 2018-11-29 | 2023-04-18 | Surmodics, Inc. | Apparatus and methods for coating medical devices |
US11819590B2 (en) | 2019-05-13 | 2023-11-21 | Surmodics, Inc. | Apparatus and methods for coating medical devices |
Family Cites Families (249)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7213A (en) * | 1850-03-26 | Improvement in seed-planters | ||
US32434A (en) * | 1861-05-28 | Improvement in animal-traps | ||
US4069307A (en) * | 1970-10-01 | 1978-01-17 | Alza Corporation | Drug-delivery device comprising certain polymeric materials for controlled release of drug |
CA1045977A (en) | 1973-05-17 | 1979-01-09 | Arthur D. Little | Biodegradable, implantable drug delivery device, and process for preparing and using the same |
US4391797A (en) | 1977-01-05 | 1983-07-05 | The Children's Hospital Medical Center | Systems for the controlled release of macromolecules |
US4292965A (en) * | 1978-12-29 | 1981-10-06 | The Population Council, Inc. | Intravaginal ring |
DE2920500A1 (en) | 1979-05-21 | 1980-11-27 | Boehringer Sohn Ingelheim | PHARMACEUTICAL PREPARATION IN THE FORM OF A POLYACRYLATE FILM |
US5310559A (en) * | 1982-09-01 | 1994-05-10 | Hercon Laboratories Corporation | Device for controlled release and delivery to mammalian tissue of pharmacologically active agents incorporating a rate controlling member which comprises an alkylene-alkyl acrylate copolymer |
US5217492A (en) * | 1982-09-29 | 1993-06-08 | Bio-Metric Systems, Inc. | Biomolecule attachment to hydrophobic surfaces |
US4973493A (en) * | 1982-09-29 | 1990-11-27 | Bio-Metric Systems, Inc. | Method of improving the biocompatibility of solid surfaces |
US5512329A (en) * | 1982-09-29 | 1996-04-30 | Bsi Corporation | Substrate surface preparation |
US5002582A (en) * | 1982-09-29 | 1991-03-26 | Bio-Metric Systems, Inc. | Preparation of polymeric surfaces via covalently attaching polymers |
US5258041A (en) * | 1982-09-29 | 1993-11-02 | Bio-Metric Systems, Inc. | Method of biomolecule attachment to hydrophobic surfaces |
US4722906A (en) * | 1982-09-29 | 1988-02-02 | Bio-Metric Systems, Inc. | Binding reagents and methods |
US4603152A (en) * | 1982-11-05 | 1986-07-29 | Baxter Travenol Laboratories, Inc. | Antimicrobial compositions |
US4693887A (en) | 1983-09-15 | 1987-09-15 | The Kendall Company | Microphase separated hydrogels for controlled release of bioactive materials |
DE3344691A1 (en) * | 1983-12-10 | 1985-06-20 | Bayer Ag, 5090 Leverkusen | ACTIVE GAS EXHAUST SYSTEMS |
DE3347278A1 (en) * | 1983-12-28 | 1985-07-11 | Bayer Ag, 5090 Leverkusen | ACTIVE SUBSTANCE DELIVERY SYSTEMS |
US6309669B1 (en) | 1984-03-16 | 2001-10-30 | The United States Of America As Represented By The Secretary Of The Army | Therapeutic treatment and prevention of infections with a bioactive materials encapsulated within a biodegradable-biocompatible polymeric matrix |
WO1986001813A1 (en) * | 1984-09-21 | 1986-03-27 | Raychem Corporation | Multiple phase polymeric compositions |
US4826759A (en) * | 1984-10-04 | 1989-05-02 | Bio-Metric Systems, Inc. | Field assay for ligands |
GB8527071D0 (en) * | 1985-11-04 | 1985-12-11 | Biocompatibles Ltd | Plastics |
EP0257091B1 (en) | 1986-02-24 | 1993-07-28 | Robert E. Fischell | An intravascular stent and percutaneous insertion system |
US4959217A (en) * | 1986-05-22 | 1990-09-25 | Syntex (U.S.A.) Inc. | Delayed/sustained release of macromolecules |
US4979959A (en) * | 1986-10-17 | 1990-12-25 | Bio-Metric Systems, Inc. | Biocompatible coating for solid surfaces |
US5263992A (en) * | 1986-10-17 | 1993-11-23 | Bio-Metric Systems, Inc. | Biocompatible device with covalently bonded biocompatible agent |
US4893623A (en) | 1986-12-09 | 1990-01-16 | Advanced Surgical Intervention, Inc. | Method and apparatus for treating hypertrophy of the prostate gland |
AU606383B2 (en) | 1987-03-06 | 1991-02-07 | Research Triangle Institute | Polymer blends for selective biodegradability |
US5114719A (en) * | 1987-04-29 | 1992-05-19 | Sabel Bernhard A | Extended drug delivery of small, water-soluble molecules |
US5985354A (en) | 1995-06-07 | 1999-11-16 | Brown University Research Foundation | Preparation of multiwall polymeric microcapsules from hydrophilic polymers |
NL8701337A (en) | 1987-06-09 | 1989-01-02 | Sentron V O F | SUBSTRATE PROVIDED WITH A BLOOD COMPATIBLE SURFACE OBTAINED BY COUPLING WITH THE SURFACE OF A PHYSIOLOGICALLY ACTIVE SUBSTANCE WITH AN INHIBITORY INFLUENCE ON THE FORMATION OF BLOOD CLOTS AND / OR CONTAINED FROM HARMFOLIC CIRCULARS. |
US4968539A (en) | 1987-12-01 | 1990-11-06 | Lion Corporation | Liquid crystal membrane |
US4916193A (en) | 1987-12-17 | 1990-04-10 | Allied-Signal Inc. | Medical devices fabricated totally or in part from copolymers of recurring units derived from cyclic carbonates and lactides |
US4867968A (en) | 1987-12-29 | 1989-09-19 | Florida-Kansas Health Care, Inc. | Elastomeric composition containing therapeutic agents and articles manufactured therefrom |
US5019096A (en) * | 1988-02-11 | 1991-05-28 | Trustees Of Columbia University In The City Of New York | Infection-resistant compositions, medical devices and surfaces and methods for preparing and using same |
US5660692A (en) | 1988-02-24 | 1997-08-26 | Cedars-Sinai Medical Center | Method of crosslinking amino acid-containing polymers using photoactivatable chemical crosslinkers |
US5024742A (en) | 1988-02-24 | 1991-06-18 | Cedars-Sinai Medical Center | Method of crosslinking amino acid containing polymers using photoactivatable chemical crosslinkers |
US5474783A (en) | 1988-03-04 | 1995-12-12 | Noven Pharmaceuticals, Inc. | Solubility parameter based drug delivery system and method for altering drug saturation concentration |
US5656286A (en) * | 1988-03-04 | 1997-08-12 | Noven Pharmaceuticals, Inc. | Solubility parameter based drug delivery system and method for altering drug saturation concentration |
US5165952A (en) * | 1989-01-18 | 1992-11-24 | Becton, Dickinson And Company | Anti-infective and antithrombogenic medical articles and method for their preparation |
US4994071A (en) | 1989-05-22 | 1991-02-19 | Cordis Corporation | Bifurcating stent apparatus and method |
WO1991003990A1 (en) * | 1989-09-15 | 1991-04-04 | Chiron Ophthalmics, Inc. | Method for achieving epithelialization of synthetic lenses |
US5525348A (en) * | 1989-11-02 | 1996-06-11 | Sts Biopolymers, Inc. | Coating compositions comprising pharmaceutical agents |
US5304121A (en) | 1990-12-28 | 1994-04-19 | Boston Scientific Corporation | Drug delivery system making use of a hydrogel polymer coating |
US5545208A (en) * | 1990-02-28 | 1996-08-13 | Medtronic, Inc. | Intralumenal drug eluting prosthesis |
WO1991017724A1 (en) * | 1990-05-17 | 1991-11-28 | Harbor Medical Devices, Inc. | Medical device polymer |
ATE130517T1 (en) | 1990-08-08 | 1995-12-15 | Takeda Chemical Industries Ltd | INTRAVASCULAR EMBOLIZING AGENT CONTAINING A SUBSTANCE INHIBITING ANGIOGENESIS. |
US5180366A (en) * | 1990-10-10 | 1993-01-19 | Woods W T | Apparatus and method for angioplasty and for preventing re-stenosis |
AU1579092A (en) * | 1991-02-27 | 1992-10-06 | Nova Pharmaceutical Corporation | Anti-infective and anti-inflammatory releasing systems for medical devices |
US5437656A (en) | 1991-02-27 | 1995-08-01 | Leonard Bloom | Method and device for inhibiting H.I.V. hepatitis B and other viruses and germs when using a needle, scalpel and other sharp instrument in a medical environment |
US5221698A (en) | 1991-06-27 | 1993-06-22 | The Regents Of The University Of Michigan | Bioactive composition |
US5356433A (en) * | 1991-08-13 | 1994-10-18 | Cordis Corporation | Biocompatible metal surfaces |
DE69232928D1 (en) * | 1991-08-23 | 2003-03-27 | Alberta Res Council | METHOD AND COMPOSITIONS FOR PREVENTING THE ANTIBODY-MEDIATED REPELLATION OF XENOGENIC TRANSPLANTS |
KR960009351B1 (en) * | 1991-09-26 | 1996-07-18 | 마쯔다 가부시기가이샤 | Torque detection system |
US5270047A (en) | 1991-11-21 | 1993-12-14 | Kauffman Raymond F | Local delivery of dipyridamole for the treatment of proliferative diseases |
US5273760A (en) | 1991-12-24 | 1993-12-28 | Euroceltigue, S.A. | Stabilized controlled release substrate having a coating derived from an aqueous dispersion of hydrophobic polymer |
US5681585A (en) * | 1991-12-24 | 1997-10-28 | Euro-Celtique, S.A. | Stabilized controlled release substrate having a coating derived from an aqueous dispersion of hydrophobic polymer |
CA2086642C (en) | 1992-01-09 | 2004-06-15 | Randall E. Morris | Method of treating hyperproliferative vascular disease |
EP0585436B1 (en) * | 1992-02-13 | 2000-05-03 | SurModics, Inc. | Immobilization of chemical species in crosslinked matrices |
US5599352A (en) * | 1992-03-19 | 1997-02-04 | Medtronic, Inc. | Method of making a drug eluting stent |
AU670937B2 (en) | 1992-04-28 | 1996-08-08 | Wyeth | Method of treating hyperproliferative vascular disease |
US5248732A (en) | 1992-06-01 | 1993-09-28 | Enichem S.P.A. | Blends of polyetherimides, aromatic alkyl methacrylates and polycarbonates |
US5578075B1 (en) | 1992-11-04 | 2000-02-08 | Daynke Res Inc | Minimally invasive bioactivated endoprosthesis for vessel repair |
US5449382A (en) * | 1992-11-04 | 1995-09-12 | Dayton; Michael P. | Minimally invasive bioactivated endoprosthesis for vessel repair |
US5414075A (en) * | 1992-11-06 | 1995-05-09 | Bsi Corporation | Restrained multifunctional reagent for surface modification |
US5342348A (en) * | 1992-12-04 | 1994-08-30 | Kaplan Aaron V | Method and device for treating and enlarging body lumens |
EP0604022A1 (en) | 1992-12-22 | 1994-06-29 | Advanced Cardiovascular Systems, Inc. | Multilayered biodegradable stent and method for its manufacture |
US5419760A (en) * | 1993-01-08 | 1995-05-30 | Pdt Systems, Inc. | Medicament dispensing stent for prevention of restenosis of a blood vessel |
US6491938B2 (en) | 1993-05-13 | 2002-12-10 | Neorx Corporation | Therapeutic inhibitor of vascular smooth muscle cells |
US5464650A (en) * | 1993-04-26 | 1995-11-07 | Medtronic, Inc. | Intravascular stent and method |
US20020055710A1 (en) | 1998-04-30 | 2002-05-09 | Ronald J. Tuch | Medical device for delivering a therapeutic agent and method of preparation |
IL110014A (en) * | 1993-07-01 | 1999-11-30 | Euro Celtique Sa | Solid controlled-release oral dosage forms of opioid analgesics |
JPH0717851A (en) * | 1993-07-02 | 1995-01-20 | Teijin Ltd | Drug-containing salve using (meth)acrylic ester-based sticking agent |
ATE502664T1 (en) | 1993-07-19 | 2011-04-15 | Angiotech Pharm Inc | METHOD OF PRODUCTION OF A STENT WITH ANTI-ANGIOGENIC COMPOSITION |
US20030203976A1 (en) | 1993-07-19 | 2003-10-30 | William L. Hunter | Anti-angiogenic compositions and methods of use |
US5994341A (en) * | 1993-07-19 | 1999-11-30 | Angiogenesis Technologies, Inc. | Anti-angiogenic Compositions and methods for the treatment of arthritis |
JPH0753835A (en) * | 1993-08-10 | 1995-02-28 | Takeda Chem Ind Ltd | Core polymer and core-shell polymer containing active component and production thereof |
US5380299A (en) * | 1993-08-30 | 1995-01-10 | Med Institute, Inc. | Thrombolytic treated intravascular medical device |
US5443505A (en) * | 1993-11-15 | 1995-08-22 | Oculex Pharmaceuticals, Inc. | Biocompatible ocular implants |
US5849843A (en) | 1993-11-16 | 1998-12-15 | Baxter International Inc. | Polymeric compositions for medical packaging and devices |
WO1995013830A1 (en) | 1993-11-17 | 1995-05-26 | Massachusetts Institute Of Technology | Method for inhibiting angiogenesis using heparinase |
US5466233A (en) * | 1994-04-25 | 1995-11-14 | Escalon Ophthalmics, Inc. | Tack for intraocular drug delivery and method for inserting and removing same |
US6447796B1 (en) | 1994-05-16 | 2002-09-10 | The United States Of America As Represented By The Secretary Of The Army | Sustained release hydrophobic bioactive PLGA microspheres |
EP0772467A1 (en) | 1994-07-22 | 1997-05-14 | Advanced Cardiovascular Systems, Inc. | Hydrophilic coating material for intracorporeal use |
US5626862A (en) * | 1994-08-02 | 1997-05-06 | Massachusetts Institute Of Technology | Controlled local delivery of chemotherapeutic agents for treating solid tumors |
US5641501A (en) | 1994-10-11 | 1997-06-24 | Ethicon, Inc. | Absorbable polymer blends |
US5637113A (en) | 1994-12-13 | 1997-06-10 | Advanced Cardiovascular Systems, Inc. | Polymer film for wrapping a stent structure |
FR2728463A1 (en) | 1994-12-21 | 1996-06-28 | Lhd Lab Hygiene Dietetique | TRANSDERMIC SYSTEM FOR SIMULTANEOUS DELIVERY OF SEVERAL ACTIVE PRINCIPLES |
US5688900A (en) | 1995-01-19 | 1997-11-18 | Ethicon, Inc. | Absorbable polyalkylene diglycolates |
EP0808153B1 (en) * | 1995-02-10 | 1999-08-04 | Medtronic, Inc. | Method and device for administering analgesics |
US5676972A (en) | 1995-02-16 | 1997-10-14 | The University Of Akron | Time-release delivery matrix composition and corresponding controlled-release compositions |
CA2213403C (en) * | 1995-02-22 | 2007-01-16 | Menlo Care, Inc. | Covered expanding mesh stent |
US5859150A (en) | 1995-03-06 | 1999-01-12 | Ethicon, Inc. | Prepolymers of absorbable polyoxaesters |
US5648088A (en) | 1995-03-06 | 1997-07-15 | Ethicon, Inc. | Blends of absorbable polyoxaesters containing amines and/or amide groups |
US5618552A (en) | 1995-03-06 | 1997-04-08 | Ethicon, Inc. | Absorbable polyoxaesters |
US5607687A (en) | 1995-03-06 | 1997-03-04 | Ethicon, Inc. | Polymer blends containing absorbable polyoxaesters |
US5605696A (en) * | 1995-03-30 | 1997-02-25 | Advanced Cardiovascular Systems, Inc. | Drug loaded polymeric material and method of manufacture |
US6099562A (en) * | 1996-06-13 | 2000-08-08 | Schneider (Usa) Inc. | Drug coating with topcoat |
AU4952096A (en) | 1995-04-19 | 1996-11-07 | Schneider (Usa) Inc. | Drug release coated stent |
US6120536A (en) * | 1995-04-19 | 2000-09-19 | Schneider (Usa) Inc. | Medical devices with long term non-thrombogenic coatings |
US5837313A (en) | 1995-04-19 | 1998-11-17 | Schneider (Usa) Inc | Drug release stent coating process |
US20020091433A1 (en) | 1995-04-19 | 2002-07-11 | Ni Ding | Drug release coated stent |
DE69634013T2 (en) * | 1995-05-26 | 2005-12-15 | SurModics, Inc., Eden Prairie | PROCESS AND IMPLANTABLE OBJECT FOR PROMOTING ENDOTHELIALIZATION |
US6774278B1 (en) | 1995-06-07 | 2004-08-10 | Cook Incorporated | Coated implantable medical device |
US5731087A (en) | 1995-06-07 | 1998-03-24 | Union Carbide Chemicals & Plastics Technology Corporation | Lubricious coatings containing polymers with vinyl and carboxylic acid moieties |
US5840059A (en) | 1995-06-07 | 1998-11-24 | Cardiogenesis Corporation | Therapeutic and diagnostic agent delivery |
US5783502A (en) * | 1995-06-07 | 1998-07-21 | Bsi Corporation | Virus inactivating coatings |
US5609629A (en) * | 1995-06-07 | 1997-03-11 | Med Institute, Inc. | Coated implantable medical device |
CA2178541C (en) * | 1995-06-07 | 2009-11-24 | Neal E. Fearnot | Implantable medical device |
US5633343A (en) | 1995-06-30 | 1997-05-27 | Ethicon, Inc. | High strength, fast absorbing, melt processable, gycolide-rich, poly(glycolide-co-p-dioxanone) copolymers |
US5877224A (en) * | 1995-07-28 | 1999-03-02 | Rutgers, The State University Of New Jersey | Polymeric drug formulations |
US5607475A (en) | 1995-08-22 | 1997-03-04 | Medtronic, Inc. | Biocompatible medical article and method |
US5773019A (en) * | 1995-09-27 | 1998-06-30 | The University Of Kentucky Research Foundation | Implantable controlled release device to deliver drugs directly to an internal portion of the body |
US5722424A (en) | 1995-09-29 | 1998-03-03 | Target Therapeutics, Inc. | Multi-coating stainless steel guidewire |
US5639851A (en) | 1995-10-02 | 1997-06-17 | Ethicon, Inc. | High strength, melt processable, lactide-rich, poly(lactide-CO-P-dioxanone) copolymers |
US5714360A (en) * | 1995-11-03 | 1998-02-03 | Bsi Corporation | Photoactivatable water soluble cross-linking agents containing an onium group |
US5981298A (en) * | 1995-12-13 | 1999-11-09 | Surmodics, Inc. | Immunoassay device and method |
JP3985907B2 (en) * | 1996-01-18 | 2007-10-03 | 旭化成ケミカルズ株式会社 | Method for producing film coating granules |
US6368586B1 (en) | 1996-01-26 | 2002-04-09 | Brown University Research Foundation | Methods and compositions for enhancing the bioadhesive properties of polymers |
US5703200A (en) | 1996-03-15 | 1997-12-30 | Ethicon, Inc. | Absorbable copolymers and blends of 6,6-dialkyl-1,4-dioxepan-2-one and its cyclic dimer |
US5942555A (en) * | 1996-03-21 | 1999-08-24 | Surmodics, Inc. | Photoactivatable chain transfer agents and semi-telechelic photoactivatable polymers prepared therefrom |
US5713949A (en) * | 1996-08-06 | 1998-02-03 | Jayaraman; Swaminathan | Microporous covered stents and method of coating |
US20030094736A1 (en) | 1996-05-03 | 2003-05-22 | Chuan Qin | Method of surface modifying a medical tubing |
US5951586A (en) * | 1996-05-15 | 1999-09-14 | Medtronic, Inc. | Intraluminal stent |
US6143037A (en) * | 1996-06-12 | 2000-11-07 | The Regents Of The University Of Michigan | Compositions and methods for coating medical devices |
EP0842657A1 (en) | 1996-11-19 | 1998-05-20 | OctoPlus B.V. | Microspheres for controlled release and processes to prepare these microspheres |
US6495579B1 (en) * | 1996-12-02 | 2002-12-17 | Angiotech Pharmaceuticals, Inc. | Method for treating multiple sclerosis |
US20030157187A1 (en) | 1996-12-02 | 2003-08-21 | Angiotech Pharmaceuticals, Inc. | Compositions and methods for treating or preventing inflammatory diseases |
FR2757528A1 (en) | 1996-12-20 | 1998-06-26 | Dow Corning | Interpenetrating polymer network used e.g. for reinforcing agents in silicone rubbers |
US5980972A (en) * | 1996-12-20 | 1999-11-09 | Schneider (Usa) Inc | Method of applying drug-release coatings |
US5997517A (en) | 1997-01-27 | 1999-12-07 | Sts Biopolymers, Inc. | Bonding layers for medical device surface coatings |
US5902475A (en) * | 1997-04-08 | 1999-05-11 | Interventional Technologies, Inc. | Method for manufacturing a stent |
US6273913B1 (en) | 1997-04-18 | 2001-08-14 | Cordis Corporation | Modified stent useful for delivery of drugs along stent strut |
US5879697A (en) | 1997-04-30 | 1999-03-09 | Schneider Usa Inc | Drug-releasing coatings for medical devices |
WO1998051238A1 (en) * | 1997-05-14 | 1998-11-19 | Novo Rps Ulc | Expandable stent and method for production of same |
US6077916A (en) | 1997-06-04 | 2000-06-20 | The Penn State Research Foundation | Biodegradable mixtures of polyphoshazene and other polymers |
US6110483A (en) * | 1997-06-23 | 2000-08-29 | Sts Biopolymers, Inc. | Adherent, flexible hydrogel and medicated coatings |
US5899935A (en) * | 1997-08-04 | 1999-05-04 | Schneider (Usa) Inc. | Balloon expandable braided stent with restraint |
US5897911A (en) * | 1997-08-11 | 1999-04-27 | Advanced Cardiovascular Systems, Inc. | Polymer-coated stent structure |
US6121027A (en) * | 1997-08-15 | 2000-09-19 | Surmodics, Inc. | Polybifunctional reagent having a polymeric backbone and photoreactive moieties and bioactive groups |
US5858653A (en) * | 1997-09-30 | 1999-01-12 | Surmodics, Inc. | Reagent and method for attaching target molecules to a surface |
WO1999019381A1 (en) | 1997-10-09 | 1999-04-22 | Teijin Limited | Medical material containing fluorinated polysulfone having excellent antithrombotic activity |
US20020164374A1 (en) | 1997-10-29 | 2002-11-07 | John Jackson | Polymeric systems for drug delivery and uses thereof |
US6884721B2 (en) | 1997-12-25 | 2005-04-26 | Shin-Etsu Handotai Co., Ltd. | Silicon wafer storage water and silicon wafer storage method |
US6221425B1 (en) * | 1998-01-30 | 2001-04-24 | Advanced Cardiovascular Systems, Inc. | Lubricious hydrophilic coating for an intracorporeal medical device |
US6007833A (en) * | 1998-03-19 | 1999-12-28 | Surmodics, Inc. | Crosslinkable macromers bearing initiator groups |
DE69820023T2 (en) | 1998-03-26 | 2004-09-02 | Biomat B.V. | Endovascular vascular prostheses with a polymer coating |
US20010029351A1 (en) * | 1998-04-16 | 2001-10-11 | Robert Falotico | Drug combinations and delivery devices for the prevention and treatment of vascular disease |
US6074660A (en) | 1998-04-20 | 2000-06-13 | Ethicon, Inc. | Absorbable polyoxaesters containing amines and/ or amido groups |
EP1555036B1 (en) * | 1998-04-27 | 2010-05-05 | Surmodics Inc. | Bioactive agent release coating |
US20020188037A1 (en) * | 1999-04-15 | 2002-12-12 | Chudzik Stephen J. | Method and system for providing bioactive agent release coating |
US6013099A (en) * | 1998-04-29 | 2000-01-11 | Medtronic, Inc. | Medical device for delivering a water-insoluble therapeutic salt or substance |
US6254634B1 (en) | 1998-06-10 | 2001-07-03 | Surmodics, Inc. | Coating compositions |
US6153252A (en) * | 1998-06-30 | 2000-11-28 | Ethicon, Inc. | Process for coating stents |
US6335029B1 (en) | 1998-08-28 | 2002-01-01 | Scimed Life Systems, Inc. | Polymeric coatings for controlled delivery of active agents |
US6120847A (en) * | 1999-01-08 | 2000-09-19 | Scimed Life Systems, Inc. | Surface treatment method for stent coating |
US6530950B1 (en) | 1999-01-12 | 2003-03-11 | Quanam Medical Corporation | Intraluminal stent having coaxial polymer member |
US6395029B1 (en) | 1999-01-19 | 2002-05-28 | The Children's Hospital Of Philadelphia | Sustained delivery of polyionic bioactive agents |
US6565872B2 (en) | 1999-02-16 | 2003-05-20 | Xiao Yu Wu | Polymeric system for drug delivery and solute separation |
US6217895B1 (en) * | 1999-03-22 | 2001-04-17 | Control Delivery Systems | Method for treating and/or preventing retinal diseases with sustained release corticosteroids |
ES2295021T3 (en) | 1999-03-25 | 2008-04-16 | Metabolix, Inc. | USE AND MEDICAL APPLICATIONS OF POLYMER POLYMERS (HYDROXIALCANOATS). |
US6156373A (en) * | 1999-05-03 | 2000-12-05 | Scimed Life Systems, Inc. | Medical device coating methods and devices |
US6325807B1 (en) | 1999-06-11 | 2001-12-04 | Scimed Life Systems, Inc. | Variable strength sheath |
US6258121B1 (en) | 1999-07-02 | 2001-07-10 | Scimed Life Systems, Inc. | Stent coating |
US6596296B1 (en) | 1999-08-06 | 2003-07-22 | Board Of Regents, The University Of Texas System | Drug releasing biodegradable fiber implant |
US6790228B2 (en) * | 1999-12-23 | 2004-09-14 | Advanced Cardiovascular Systems, Inc. | Coating for implantable devices and a method of forming the same |
US6331313B1 (en) * | 1999-10-22 | 2001-12-18 | Oculex Pharmaceticals, Inc. | Controlled-release biocompatible ocular drug delivery implant devices and methods |
US6800073B2 (en) | 1999-10-28 | 2004-10-05 | Scimed Life Systems, Inc. | Biocompatible pharmaceutical articles |
US6251136B1 (en) * | 1999-12-08 | 2001-06-26 | Advanced Cardiovascular Systems, Inc. | Method of layering a three-coated stent using pharmacological and polymeric agents |
US6338739B1 (en) | 1999-12-22 | 2002-01-15 | Ethicon, Inc. | Biodegradable stent |
US6908624B2 (en) | 1999-12-23 | 2005-06-21 | Advanced Cardiovascular Systems, Inc. | Coating for implantable devices and a method of forming the same |
ATE460951T1 (en) | 2000-01-25 | 2010-04-15 | Edwards Lifesciences Corp | RELEASE SYSTEMS FOR THE TREATMENT OF RESTENOSIS AND ANASTOMOTIC INTIMAL HYPERPLASIA |
WO2001078626A1 (en) * | 2000-04-13 | 2001-10-25 | Sts Biopolymers, Inc. | Targeted therapeutic agent release devices and methods of making and using the same |
US20020005206A1 (en) * | 2000-05-19 | 2002-01-17 | Robert Falotico | Antiproliferative drug and delivery device |
US20020007214A1 (en) * | 2000-05-19 | 2002-01-17 | Robert Falotico | Drug/drug delivery systems for the prevention and treatment of vascular disease |
US20020007213A1 (en) | 2000-05-19 | 2002-01-17 | Robert Falotico | Drug/drug delivery systems for the prevention and treatment of vascular disease |
US20020007215A1 (en) * | 2000-05-19 | 2002-01-17 | Robert Falotico | Drug/drug delivery systems for the prevention and treatment of vascular disease |
US6776796B2 (en) | 2000-05-12 | 2004-08-17 | Cordis Corportation | Antiinflammatory drug and delivery device |
JP4268741B2 (en) * | 2000-07-03 | 2009-05-27 | 株式会社ニデック | Soft intraocular lens |
US6451373B1 (en) | 2000-08-04 | 2002-09-17 | Advanced Cardiovascular Systems, Inc. | Method of forming a therapeutic coating onto a surface of an implantable prosthesis |
ATE343969T1 (en) | 2000-09-29 | 2006-11-15 | Cordis Corp | COATED MEDICAL DEVICES |
US7261735B2 (en) | 2001-05-07 | 2007-08-28 | Cordis Corporation | Local drug delivery devices and methods for maintaining the drug coatings thereon |
US20020051730A1 (en) * | 2000-09-29 | 2002-05-02 | Stanko Bodnar | Coated medical devices and sterilization thereof |
US20020111590A1 (en) | 2000-09-29 | 2002-08-15 | Davila Luis A. | Medical devices, drug coatings and methods for maintaining the drug coatings thereon |
US6746773B2 (en) * | 2000-09-29 | 2004-06-08 | Ethicon, Inc. | Coatings for medical devices |
US6545097B2 (en) | 2000-12-12 | 2003-04-08 | Scimed Life Systems, Inc. | Drug delivery compositions and medical devices containing block copolymer |
US6517520B2 (en) | 2000-12-21 | 2003-02-11 | Ethicon Endo Surgery, Inc. | Peripherally inserted catheter with flushable guide-tube |
US7077859B2 (en) | 2000-12-22 | 2006-07-18 | Avantec Vascular Corporation | Apparatus and methods for variably controlled substance delivery from implanted prostheses |
US6824559B2 (en) | 2000-12-22 | 2004-11-30 | Advanced Cardiovascular Systems, Inc. | Ethylene-carboxyl copolymers as drug delivery matrices |
US6682553B1 (en) | 2000-12-28 | 2004-01-27 | Advanced Cardiovascular Systems, Inc. | System and method for stent retention |
GB0100761D0 (en) | 2001-01-11 | 2001-02-21 | Biocompatibles Ltd | Drug delivery from stents |
US6713081B2 (en) | 2001-03-15 | 2004-03-30 | The United States Of America As Represented By The Department Of Health And Human Services | Ocular therapeutic agent delivery devices and methods for making and using such devices |
US7771468B2 (en) | 2001-03-16 | 2010-08-10 | Angiotech Biocoatings Corp. | Medicated stent having multi-layer polymer coating |
US6780424B2 (en) | 2001-03-30 | 2004-08-24 | Charles David Claude | Controlled morphologies in polymer drug for release of drugs from polymer films |
US20040022853A1 (en) | 2001-04-26 | 2004-02-05 | Control Delivery Systems, Inc. | Polymer-based, sustained release drug delivery system |
EP1383504A1 (en) | 2001-04-26 | 2004-01-28 | Control Delivery Systems, Inc. | Sustained release drug delivery system containing codrugs |
US6984393B2 (en) | 2001-05-07 | 2006-01-10 | Queen's University At Kingston | Biodegradable elastomer and method of preparing same |
US8182527B2 (en) | 2001-05-07 | 2012-05-22 | Cordis Corporation | Heparin barrier coating for controlled drug release |
US6673453B2 (en) | 2001-06-12 | 2004-01-06 | Biocoat Incorporated | Coatings appropriate for medical devices |
US6787179B2 (en) | 2001-06-29 | 2004-09-07 | Ethicon, Inc. | Sterilization of bioactive coatings |
US20040058056A1 (en) | 2001-07-06 | 2004-03-25 | Shigemasa Osaki | Drug diffusion coatings, applications and methods |
US6497691B1 (en) | 2001-08-24 | 2002-12-24 | Polymer Group, Inc. | Structurally durable, drapeable breathable barrier film compositions and articles |
US20030158598A1 (en) | 2001-09-17 | 2003-08-21 | Control Delivery Systems, Inc. | System for sustained-release delivery of anti-inflammatory agents from a coated medical device |
US6753071B1 (en) | 2001-09-27 | 2004-06-22 | Advanced Cardiovascular Systems, Inc. | Rate-reducing membrane for release of an agent |
US20030065377A1 (en) | 2001-09-28 | 2003-04-03 | Davila Luis A. | Coated medical devices |
US7682387B2 (en) | 2002-04-24 | 2010-03-23 | Biosensors International Group, Ltd. | Drug-delivery endovascular stent and method for treating restenosis |
US7585516B2 (en) | 2001-11-12 | 2009-09-08 | Advanced Cardiovascular Systems, Inc. | Coatings for drug delivery devices |
AU2003220390A1 (en) | 2002-03-18 | 2003-10-08 | Medtronic Ave Inc. | Medical devices for delivering anti-proliferative compositions to anatomical sites at risk for restenosis |
US6773888B2 (en) | 2002-04-08 | 2004-08-10 | Affymetrix, Inc. | Photoactivatable silane compounds and methods for their synthesis and use |
US20030203000A1 (en) | 2002-04-24 | 2003-10-30 | Schwarz Marlene C. | Modulation of therapeutic agent release from a polymeric carrier using solvent-based techniques |
US20030204168A1 (en) | 2002-04-30 | 2003-10-30 | Gjalt Bosma | Coated vascular devices |
US7097850B2 (en) | 2002-06-18 | 2006-08-29 | Surmodics, Inc. | Bioactive agent release coating and controlled humidity method |
US20030232087A1 (en) | 2002-06-18 | 2003-12-18 | Lawin Laurie R. | Bioactive agent release coating with aromatic poly(meth)acrylates |
US7939094B2 (en) | 2002-06-19 | 2011-05-10 | Boston Scientific Scimed, Inc. | Multiphase polymeric drug release region |
US20030236513A1 (en) | 2002-06-19 | 2003-12-25 | Scimed Life Systems, Inc. | Implantable or insertable medical devices for controlled delivery of a therapeutic agent |
US8211455B2 (en) | 2002-06-19 | 2012-07-03 | Boston Scientific Scimed, Inc. | Implantable or insertable medical devices for controlled delivery of a therapeutic agent |
WO2004009664A2 (en) | 2002-07-19 | 2004-01-29 | Omeros Corporation | Biodegradable triblock copolymers, synthesis methods therefor, and hydrogels and biomaterials made there from |
ATE459380T1 (en) | 2002-08-13 | 2010-03-15 | Medtronic Inc | DOSAGE SYSTEMS OF ACTIVE INGREDIENTS WITH POLY(ETHYLENE-CO(METH)ACRYLATES, MEDICAL DEVICE AND METHOD |
US20040033251A1 (en) | 2002-08-13 | 2004-02-19 | Medtronic, Inc. | Active agent delivery system including a polyurethane, medical device, and method |
DE60333566D1 (en) | 2002-08-13 | 2010-09-09 | Medtronic Inc | MEDICAL DEVICE WITH IMPROVED LIABILITY BETWEEN A POLYMERIC TOUCH AND A SUBSTRATE |
ATE374049T1 (en) | 2002-08-13 | 2007-10-15 | Medtronic Inc | SYSTEM FOR DELIVERING ACTIVE INGREDIENTS WITH A HYDROPHOBIC CELLULOSE DERIVATIVE |
WO2004014451A1 (en) | 2002-08-13 | 2004-02-19 | Medtronic, Inc. | Active agent delivery systems, medical devices, and methods |
JP2006502136A (en) | 2002-08-13 | 2006-01-19 | メドトロニック・インコーポレーテッド | Active agent delivery system comprising a hydrophilic polymer, a medical device, and a method |
JP2006510735A (en) * | 2002-08-19 | 2006-03-30 | ジェネンテック・インコーポレーテッド | Compositions and methods for tumor diagnosis and treatment |
US20040054104A1 (en) | 2002-09-05 | 2004-03-18 | Pacetti Stephen D. | Coatings for drug delivery devices comprising modified poly(ethylene-co-vinyl alcohol) |
JP2006500996A (en) | 2002-09-26 | 2006-01-12 | エンドバスキュラー デバイセス インコーポレイテッド | Apparatus and method for delivering mitomycin via an eluting biocompatible implantable medical device |
US7125577B2 (en) | 2002-09-27 | 2006-10-24 | Surmodics, Inc | Method and apparatus for coating of substrates |
US6800663B2 (en) | 2002-10-18 | 2004-10-05 | Alkermes Controlled Therapeutics Inc. Ii, | Crosslinked hydrogel copolymers |
US20040111144A1 (en) | 2002-12-06 | 2004-06-10 | Lawin Laurie R. | Barriers for polymeric coatings |
CA2519503C (en) | 2003-02-28 | 2015-04-28 | Biointeractions Ltd. | Drug delivery from a polymer coating on a medical device |
US8313759B2 (en) | 2003-03-06 | 2012-11-20 | Boston Scientific Scimed, Inc. | Implantable or insertable medical devices containing miscible polymer blends for controlled delivery of a therapeutic agent |
US7241455B2 (en) | 2003-04-08 | 2007-07-10 | Boston Scientific Scimed, Inc. | Implantable or insertable medical devices containing radiation-crosslinked polymer for controlled delivery of a therapeutic agent |
US20040230298A1 (en) | 2003-04-25 | 2004-11-18 | Medtronic Vascular, Inc. | Drug-polymer coated stent with polysulfone and styrenic block copolymer |
EP1633320A2 (en) | 2003-05-02 | 2006-03-15 | SurModics, Inc. | Implantable controlled release bioactive agent delivery device |
US7279174B2 (en) | 2003-05-08 | 2007-10-09 | Advanced Cardiovascular Systems, Inc. | Stent coatings comprising hydrophilic additives |
US7186789B2 (en) | 2003-06-11 | 2007-03-06 | Advanced Cardiovascular Systems, Inc. | Bioabsorbable, biobeneficial polyester polymers for use in drug eluting stent coatings |
NL1023720C2 (en) | 2003-06-23 | 2004-12-28 | Univ Eindhoven Tech | Method for changing the transport properties of a material, method for releasing a drug from an implant, as well as implant with drug. |
JP2007520421A (en) * | 2003-06-26 | 2007-07-26 | コリア リサーチ インスティテュート オブ ケミカル テクノロジー | Controlled release drug delivery system for oral administration |
US9114199B2 (en) | 2003-07-31 | 2015-08-25 | Boston Scientific Scimed, Inc. | Implantable or insertable medical devices containing acrylic copolymer for controlled delivery of therapeutic agent |
US20050033417A1 (en) | 2003-07-31 | 2005-02-10 | John Borges | Coating for controlled release of a therapeutic agent |
US20050037047A1 (en) | 2003-08-11 | 2005-02-17 | Young-Ho Song | Medical devices comprising spray dried microparticles |
US20050037048A1 (en) | 2003-08-11 | 2005-02-17 | Young-Ho Song | Medical devices containing antioxidant and therapeutic agent |
US20050064011A1 (en) | 2003-08-11 | 2005-03-24 | Young-Ho Song | Implantable or insertable medical devices containing phenolic compound for inhibition of restenosis |
US20050037052A1 (en) | 2003-08-13 | 2005-02-17 | Medtronic Vascular, Inc. | Stent coating with gradient porosity |
WO2005018697A2 (en) | 2003-08-13 | 2005-03-03 | Medtronic, Inc. | Active agent delivery systems, including a single layer of a miscible polymer blend, medical devices, and methods |
JP2007502281A (en) | 2003-08-13 | 2007-02-08 | メドトロニック・インコーポレーテッド | Active agent release system, medical device and method comprising a miscible polymer formulation |
US7709049B2 (en) | 2004-09-10 | 2010-05-04 | Surmodics, Inc. | Methods, devices, and coatings for controlled active agent release |
EP1819373A2 (en) | 2004-12-07 | 2007-08-22 | SurModics, Inc. | Coatings with crystallized active agent(s) |
GB0507421D0 (en) * | 2005-04-13 | 2005-05-18 | Dsm Ip Assets Bv | Aqueous coating compositions |
-
2002
- 2002-06-18 US US10/175,210 patent/US7097850B2/en not_active Expired - Lifetime
-
2003
- 2003-06-18 DE DE60328607T patent/DE60328607D1/en not_active Expired - Lifetime
- 2003-06-18 AT AT03739172T patent/ATE437665T1/en not_active IP Right Cessation
- 2003-06-18 JP JP2004512819A patent/JP4008921B2/en not_active Expired - Fee Related
- 2003-06-18 AU AU2003245547A patent/AU2003245547A1/en not_active Abandoned
- 2003-06-18 CA CA2490233A patent/CA2490233C/en not_active Expired - Fee Related
- 2003-06-18 WO PCT/US2003/019107 patent/WO2003105919A1/en active Application Filing
- 2003-06-18 EP EP03739172A patent/EP1517714B1/en not_active Expired - Lifetime
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2005
- 2005-08-19 US US11/207,380 patent/US7833548B2/en active Active
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2007
- 2007-02-14 JP JP2007033953A patent/JP2007185519A/en active Pending
-
2010
- 2010-11-08 US US12/941,132 patent/US20110054417A1/en not_active Abandoned
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US7097850B2 (en) | 2006-08-29 |
EP1517714A1 (en) | 2005-03-30 |
ATE437665T1 (en) | 2009-08-15 |
CA2490233C (en) | 2011-10-25 |
US20110054417A1 (en) | 2011-03-03 |
AU2003245547A1 (en) | 2003-12-31 |
US20070248637A1 (en) | 2007-10-25 |
JP2005535367A (en) | 2005-11-24 |
EP1517714B1 (en) | 2009-07-29 |
JP4008921B2 (en) | 2007-11-14 |
JP2007185519A (en) | 2007-07-26 |
US20030232122A1 (en) | 2003-12-18 |
US7833548B2 (en) | 2010-11-16 |
WO2003105919A1 (en) | 2003-12-24 |
DE60328607D1 (en) | 2009-09-10 |
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