CA2489506A1 - Method and apparatus for treatment of cutaneous and subcutaneous conditions - Google Patents
Method and apparatus for treatment of cutaneous and subcutaneous conditions Download PDFInfo
- Publication number
- CA2489506A1 CA2489506A1 CA002489506A CA2489506A CA2489506A1 CA 2489506 A1 CA2489506 A1 CA 2489506A1 CA 002489506 A CA002489506 A CA 002489506A CA 2489506 A CA2489506 A CA 2489506A CA 2489506 A1 CA2489506 A1 CA 2489506A1
- Authority
- CA
- Canada
- Prior art keywords
- region
- patient
- cooling
- radiation
- applicator
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
- 238000011282 treatment Methods 0.000 title claims abstract description 82
- 238000000034 method Methods 0.000 title claims abstract description 52
- 238000007920 subcutaneous administration Methods 0.000 title description 7
- 238000001816 cooling Methods 0.000 claims abstract description 92
- 230000005855 radiation Effects 0.000 claims abstract description 77
- 230000000638 stimulation Effects 0.000 claims abstract description 18
- 210000001519 tissue Anatomy 0.000 claims description 69
- 238000010438 heat treatment Methods 0.000 claims description 49
- 230000007246 mechanism Effects 0.000 claims description 29
- 230000036760 body temperature Effects 0.000 claims description 20
- 210000004003 subcutaneous fat Anatomy 0.000 claims description 16
- 210000004027 cell Anatomy 0.000 claims description 15
- 210000001789 adipocyte Anatomy 0.000 claims description 11
- 230000000694 effects Effects 0.000 claims description 11
- 230000001965 increasing effect Effects 0.000 claims description 11
- 230000001351 cycling effect Effects 0.000 claims description 6
- 230000008859 change Effects 0.000 claims description 4
- 230000004936 stimulating effect Effects 0.000 claims description 4
- 230000033001 locomotion Effects 0.000 claims description 3
- 230000002596 correlated effect Effects 0.000 claims description 2
- 210000003491 skin Anatomy 0.000 description 45
- 230000003287 optical effect Effects 0.000 description 19
- 230000006378 damage Effects 0.000 description 17
- 238000005382 thermal cycling Methods 0.000 description 16
- 238000010586 diagram Methods 0.000 description 9
- 230000001225 therapeutic effect Effects 0.000 description 9
- 208000002193 Pain Diseases 0.000 description 8
- 239000013078 crystal Substances 0.000 description 8
- 230000007423 decrease Effects 0.000 description 8
- 210000004207 dermis Anatomy 0.000 description 8
- 230000006870 function Effects 0.000 description 8
- 210000000577 adipose tissue Anatomy 0.000 description 7
- 230000008569 process Effects 0.000 description 7
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 7
- 208000035484 Cellulite Diseases 0.000 description 6
- 206010049752 Peau d'orange Diseases 0.000 description 6
- 230000008901 benefit Effects 0.000 description 6
- 230000036232 cellulite Effects 0.000 description 6
- 239000000463 material Substances 0.000 description 6
- 230000009467 reduction Effects 0.000 description 6
- 230000015572 biosynthetic process Effects 0.000 description 5
- 210000003205 muscle Anatomy 0.000 description 5
- 210000000056 organ Anatomy 0.000 description 5
- 230000010355 oscillation Effects 0.000 description 5
- 206010033675 panniculitis Diseases 0.000 description 5
- 230000017531 blood circulation Effects 0.000 description 4
- 239000002537 cosmetic Substances 0.000 description 4
- 229910052736 halogen Inorganic materials 0.000 description 4
- 150000002367 halogens Chemical class 0.000 description 4
- 230000006872 improvement Effects 0.000 description 4
- 239000010410 layer Substances 0.000 description 4
- 150000002632 lipids Chemical class 0.000 description 4
- 210000002751 lymph Anatomy 0.000 description 4
- 230000007704 transition Effects 0.000 description 4
- 230000009286 beneficial effect Effects 0.000 description 3
- 210000004204 blood vessel Anatomy 0.000 description 3
- 210000000988 bone and bone Anatomy 0.000 description 3
- 230000008878 coupling Effects 0.000 description 3
- 238000010168 coupling process Methods 0.000 description 3
- 238000005859 coupling reaction Methods 0.000 description 3
- 230000035876 healing Effects 0.000 description 3
- 150000002500 ions Chemical class 0.000 description 3
- 230000017074 necrotic cell death Effects 0.000 description 3
- 238000000554 physical therapy Methods 0.000 description 3
- 230000001681 protective effect Effects 0.000 description 3
- 102000004169 proteins and genes Human genes 0.000 description 3
- 108090000623 proteins and genes Proteins 0.000 description 3
- 230000003595 spectral effect Effects 0.000 description 3
- 238000002834 transmittance Methods 0.000 description 3
- 150000003626 triacylglycerols Chemical class 0.000 description 3
- 206010006811 Bursitis Diseases 0.000 description 2
- 102000008186 Collagen Human genes 0.000 description 2
- 108010035532 Collagen Proteins 0.000 description 2
- 206010020843 Hyperthermia Diseases 0.000 description 2
- 208000000491 Tendinopathy Diseases 0.000 description 2
- 206010043255 Tendonitis Diseases 0.000 description 2
- 208000027418 Wounds and injury Diseases 0.000 description 2
- 238000010521 absorption reaction Methods 0.000 description 2
- 230000001800 adrenalinergic effect Effects 0.000 description 2
- 230000006907 apoptotic process Effects 0.000 description 2
- 239000008280 blood Substances 0.000 description 2
- 210000004369 blood Anatomy 0.000 description 2
- 208000003295 carpal tunnel syndrome Diseases 0.000 description 2
- 230000030833 cell death Effects 0.000 description 2
- 229920001436 collagen Polymers 0.000 description 2
- 238000002425 crystallisation Methods 0.000 description 2
- 230000008025 crystallization Effects 0.000 description 2
- 230000004064 dysfunction Effects 0.000 description 2
- 230000005670 electromagnetic radiation Effects 0.000 description 2
- 238000007710 freezing Methods 0.000 description 2
- 230000036031 hyperthermia Effects 0.000 description 2
- 230000001976 improved effect Effects 0.000 description 2
- 208000014674 injury Diseases 0.000 description 2
- 230000001678 irradiating effect Effects 0.000 description 2
- 230000002427 irreversible effect Effects 0.000 description 2
- 210000003041 ligament Anatomy 0.000 description 2
- 230000004130 lipolysis Effects 0.000 description 2
- 210000004324 lymphatic system Anatomy 0.000 description 2
- 239000000203 mixture Substances 0.000 description 2
- 230000035515 penetration Effects 0.000 description 2
- 230000035699 permeability Effects 0.000 description 2
- 230000033764 rhythmic process Effects 0.000 description 2
- 229910052594 sapphire Inorganic materials 0.000 description 2
- 239000010980 sapphire Substances 0.000 description 2
- 210000001732 sebaceous gland Anatomy 0.000 description 2
- 238000001228 spectrum Methods 0.000 description 2
- 239000002344 surface layer Substances 0.000 description 2
- 210000000106 sweat gland Anatomy 0.000 description 2
- 230000002123 temporal effect Effects 0.000 description 2
- 201000004415 tendinitis Diseases 0.000 description 2
- 210000002435 tendon Anatomy 0.000 description 2
- 238000002560 therapeutic procedure Methods 0.000 description 2
- 238000011277 treatment modality Methods 0.000 description 2
- 230000002792 vascular Effects 0.000 description 2
- 230000029663 wound healing Effects 0.000 description 2
- 230000037303 wrinkles Effects 0.000 description 2
- MDVYIGJINBYKOM-IBSWDFHHSA-N 3-[(1r,2s,5r)-5-methyl-2-propan-2-ylcyclohexyl]oxypropane-1,2-diol Chemical compound CC(C)[C@@H]1CC[C@@H](C)C[C@H]1OCC(O)CO MDVYIGJINBYKOM-IBSWDFHHSA-N 0.000 description 1
- 208000002874 Acne Vulgaris Diseases 0.000 description 1
- 206010003694 Atrophy Diseases 0.000 description 1
- 208000009084 Cold Injury Diseases 0.000 description 1
- 208000012514 Cumulative Trauma disease Diseases 0.000 description 1
- IVOMOUWHDPKRLL-KQYNXXCUSA-N Cyclic adenosine monophosphate Chemical compound C([C@H]1O2)OP(O)(=O)O[C@H]1[C@@H](O)[C@@H]2N1C(N=CN=C2N)=C2N=C1 IVOMOUWHDPKRLL-KQYNXXCUSA-N 0.000 description 1
- 102000004190 Enzymes Human genes 0.000 description 1
- 108090000790 Enzymes Proteins 0.000 description 1
- 208000001640 Fibromyalgia Diseases 0.000 description 1
- 208000001034 Frostbite Diseases 0.000 description 1
- 102000034354 Gi proteins Human genes 0.000 description 1
- 108091006101 Gi proteins Proteins 0.000 description 1
- 102100026020 Hormone-sensitive lipase Human genes 0.000 description 1
- 206010061218 Inflammation Diseases 0.000 description 1
- 206010023230 Joint stiffness Diseases 0.000 description 1
- 102000004882 Lipase Human genes 0.000 description 1
- 108090001060 Lipase Proteins 0.000 description 1
- 239000004367 Lipase Substances 0.000 description 1
- 206010049287 Lipodystrophy acquired Diseases 0.000 description 1
- 206010025282 Lymphoedema Diseases 0.000 description 1
- 208000007101 Muscle Cramp Diseases 0.000 description 1
- 206010028331 Muscle rupture Diseases 0.000 description 1
- 206010028980 Neoplasm Diseases 0.000 description 1
- 206010033372 Pain and discomfort Diseases 0.000 description 1
- 201000004681 Psoriasis Diseases 0.000 description 1
- 208000005392 Spasm Diseases 0.000 description 1
- 102000000019 Sterol Esterase Human genes 0.000 description 1
- 108010055297 Sterol Esterase Proteins 0.000 description 1
- 208000004760 Tenosynovitis Diseases 0.000 description 1
- IVOMOUWHDPKRLL-UHFFFAOYSA-N UNPD107823 Natural products O1C2COP(O)(=O)OC2C(O)C1N1C(N=CN=C2N)=C2N=C1 IVOMOUWHDPKRLL-UHFFFAOYSA-N 0.000 description 1
- 206010000496 acne Diseases 0.000 description 1
- 230000009471 action Effects 0.000 description 1
- 102000030621 adenylate cyclase Human genes 0.000 description 1
- 108060000200 adenylate cyclase Proteins 0.000 description 1
- 230000037444 atrophy Effects 0.000 description 1
- 230000003190 augmentative effect Effects 0.000 description 1
- 230000005779 cell damage Effects 0.000 description 1
- 208000037887 cell injury Diseases 0.000 description 1
- 210000000170 cell membrane Anatomy 0.000 description 1
- 230000001413 cellular effect Effects 0.000 description 1
- 230000019522 cellular metabolic process Effects 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 230000002595 cold damage Effects 0.000 description 1
- 210000002808 connective tissue Anatomy 0.000 description 1
- 239000002826 coolant Substances 0.000 description 1
- 229940095074 cyclic amp Drugs 0.000 description 1
- 230000001419 dependent effect Effects 0.000 description 1
- 230000001066 destructive effect Effects 0.000 description 1
- 235000014113 dietary fatty acids Nutrition 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 230000005611 electricity Effects 0.000 description 1
- 230000003028 elevating effect Effects 0.000 description 1
- 210000002615 epidermis Anatomy 0.000 description 1
- 210000003722 extracellular fluid Anatomy 0.000 description 1
- 229930195729 fatty acid Natural products 0.000 description 1
- 239000000194 fatty acid Substances 0.000 description 1
- 150000004665 fatty acids Chemical class 0.000 description 1
- 238000001914 filtration Methods 0.000 description 1
- 230000008014 freezing Effects 0.000 description 1
- 230000012010 growth Effects 0.000 description 1
- 210000003780 hair follicle Anatomy 0.000 description 1
- 230000003779 hair growth Effects 0.000 description 1
- 230000006698 induction Effects 0.000 description 1
- 230000006882 induction of apoptosis Effects 0.000 description 1
- 208000015181 infectious disease Diseases 0.000 description 1
- 230000004054 inflammatory process Effects 0.000 description 1
- 230000000977 initiatory effect Effects 0.000 description 1
- 230000027867 intermembrane transport Effects 0.000 description 1
- 230000003834 intracellular effect Effects 0.000 description 1
- 210000000281 joint capsule Anatomy 0.000 description 1
- 235000019421 lipase Nutrition 0.000 description 1
- 208000006132 lipodystrophy Diseases 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 230000007774 longterm Effects 0.000 description 1
- 208000002502 lymphedema Diseases 0.000 description 1
- 230000003211 malignant effect Effects 0.000 description 1
- 238000004890 malting Methods 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 238000005259 measurement Methods 0.000 description 1
- 238000002844 melting Methods 0.000 description 1
- 230000008018 melting Effects 0.000 description 1
- 230000002503 metabolic effect Effects 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 231100000219 mutagenic Toxicity 0.000 description 1
- 230000003505 mutagenic effect Effects 0.000 description 1
- 230000002352 nonmutagenic effect Effects 0.000 description 1
- 230000037311 normal skin Effects 0.000 description 1
- 238000011275 oncology therapy Methods 0.000 description 1
- 230000000242 pagocytic effect Effects 0.000 description 1
- 230000008058 pain sensation Effects 0.000 description 1
- 230000001575 pathological effect Effects 0.000 description 1
- 230000001105 regulatory effect Effects 0.000 description 1
- 230000009711 regulatory function Effects 0.000 description 1
- 230000003716 rejuvenation Effects 0.000 description 1
- 238000007634 remodeling Methods 0.000 description 1
- 230000004044 response Effects 0.000 description 1
- 230000002441 reversible effect Effects 0.000 description 1
- 238000000518 rheometry Methods 0.000 description 1
- 230000000630 rising effect Effects 0.000 description 1
- 238000005096 rolling process Methods 0.000 description 1
- 231100000241 scar Toxicity 0.000 description 1
- 230000035807 sensation Effects 0.000 description 1
- 231100000430 skin reaction Toxicity 0.000 description 1
- 210000000278 spinal cord Anatomy 0.000 description 1
- 230000006641 stabilisation Effects 0.000 description 1
- 238000011105 stabilization Methods 0.000 description 1
- 210000004304 subcutaneous tissue Anatomy 0.000 description 1
- 230000001502 supplementing effect Effects 0.000 description 1
- 230000009885 systemic effect Effects 0.000 description 1
- 238000007725 thermal activation Methods 0.000 description 1
- 230000003685 thermal hair damage Effects 0.000 description 1
- 238000007669 thermal treatment Methods 0.000 description 1
- 230000035924 thermogenesis Effects 0.000 description 1
- 230000000930 thermomechanical effect Effects 0.000 description 1
- 238000000015 thermotherapy Methods 0.000 description 1
- 230000000451 tissue damage Effects 0.000 description 1
- 231100000827 tissue damage Toxicity 0.000 description 1
- 230000017423 tissue regeneration Effects 0.000 description 1
- 239000003053 toxin Substances 0.000 description 1
- 231100000765 toxin Toxicity 0.000 description 1
- 238000002604 ultrasonography Methods 0.000 description 1
- 210000005166 vasculature Anatomy 0.000 description 1
- 210000001835 viscera Anatomy 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/68—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient
- A61B5/6801—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient specially adapted to be attached to or worn on the body surface
- A61B5/6843—Monitoring or controlling sensor contact pressure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
- A61B18/18—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
- A61B18/18—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves
- A61B18/20—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves using laser
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
- A61B18/18—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves
- A61B18/20—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves using laser
- A61B18/203—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves using laser applying laser energy to the outside of the body
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/18—Applying electric currents by contact electrodes
- A61N1/20—Applying electric currents by contact electrodes continuous direct currents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/18—Applying electric currents by contact electrodes
- A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
- A61N1/328—Applying electric currents by contact electrodes alternating or intermittent currents for improving the appearance of the skin, e.g. facial toning or wrinkle treatment
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N5/00—Radiation therapy
- A61N5/06—Radiation therapy using light
- A61N5/0613—Apparatus adapted for a specific treatment
- A61N5/0616—Skin treatment other than tanning
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N5/00—Radiation therapy
- A61N5/06—Radiation therapy using light
- A61N5/0613—Apparatus adapted for a specific treatment
- A61N5/0625—Warming the body, e.g. hyperthermia treatment
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N7/00—Ultrasound therapy
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
- A61B18/04—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by heating
- A61B18/12—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by heating by passing a current through the tissue to be heated, e.g. high-frequency current
- A61B18/14—Probes or electrodes therefor
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
- A61B2018/00005—Cooling or heating of the probe or tissue immediately surrounding the probe
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
- A61B2018/00005—Cooling or heating of the probe or tissue immediately surrounding the probe
- A61B2018/00011—Cooling or heating of the probe or tissue immediately surrounding the probe with fluids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
- A61B2018/00315—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body for treatment of particular body parts
- A61B2018/00452—Skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
- A61B2018/00315—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body for treatment of particular body parts
- A61B2018/00452—Skin
- A61B2018/00458—Deeper parts of the skin, e.g. treatment of vascular disorders or port wine stains
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
- A61B2018/00315—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body for treatment of particular body parts
- A61B2018/00452—Skin
- A61B2018/00476—Hair follicles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/18—Applying electric currents by contact electrodes
- A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N5/00—Radiation therapy
- A61N5/06—Radiation therapy using light
- A61N2005/0658—Radiation therapy using light characterised by the wavelength of light used
- A61N2005/0659—Radiation therapy using light characterised by the wavelength of light used infrared
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N7/00—Ultrasound therapy
- A61N2007/0004—Applications of ultrasound therapy
- A61N2007/0008—Destruction of fat cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N7/00—Ultrasound therapy
- A61N2007/0004—Applications of ultrasound therapy
- A61N2007/0034—Skin treatment
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N5/00—Radiation therapy
- A61N5/06—Radiation therapy using light
- A61N5/0613—Apparatus adapted for a specific treatment
Abstract
The present invention provides method and apparatus for treating tissue in a region at depth while protecting non~targeted tissue by cyclically applying cooling to the patients skin, and preferably to the region, and by applying radiation to the patient's skin above the region to selectively heat tissue during and/or after cooling is applied. At least one of cooling and radiation my be applied by successivly passing a continuous output applicator over the patient's skin. Treatment may also be enhanced by applying mechanical, acoustic or electrical stimulation to the region.
Description
METHOD AND APPARATUS FOR
TREATMENT OF CUTANEOUS AND SUBCUTANEOUS CONDITIONS
CROSS-REFERENCE TO RELATED APPLICATION
This invention claims the benefit of co-pending U.S. Provisional Patent Application Serial No. 60/389,871, filed June 19, 2002, entitled "Method and Apparatus for Subdermal Heating," by G. Altshuler, et al., incorporated herein by reference in its entirety.
BACKGROUND
Field of the Invention This invention relates to methods and apparatus for the photothermal treatment of tissue and, more particularly, to methods and apparatus for treating cutaneous and subcutaneous conditions at depth.
Description of the Related Art The benefits of being able to raise and/or lower the temperature in a selected region of tissue for various therapeutic and cosmetic purposes has been known for some time. For instance, heated pads or plates or various forms of electromagnetic radiation, including visible, infrared and microwave radiation, electricity,and ultrasound have previously been used for heating subdermal muscles, ligaments, bones and the like to, for example, increase blood flow, to otherwise promote the healing of various injuries and other damage, and for various therapeutic purposes, such as frostbite or hyperthermia treatment, treatment of poor blood circulation, physical therapy, stimulation of collagen, cellulite treatment, adrenergic stimulation, wound healing, psoriasis treatment, body reshaping, non-invasive wrinkle removal, etc. The heating of tissues has also been utilized as a potential treatment for removing cancers or other undesired growths, infections and the like. Heating may be applied over a small localized area, over a larger area, for example to the hands or feet, or over larger regions of tissue, including the entire body.
Since most of the techniques described above involve applying energy to tissue at depth through the patient's skin surface, peak temperature generally occurs at or near the patient's skin surface and decrease, sometimes significantly, with depth. Further, while microwaves or ultrasonic and other acoustic radiation have been used in the past, such radiation has had _2_ limited use because, particularly for microwaves, they may be potentially mutagenic, may potentially otherwise result in cell or systemic damage and, particularly for acoustic sources, are relatively expensive.They may also not be practical for large-area treatment.
While optical and near infrared (NIR) radiation ( collectively referred to hereinafter as "optical radiation" is generally both less expensive and, being non-mutagenic, safer than microwaves radiation, the use of optical radiation has heretofore not been considered suitable for most applications involving heating of tissue at depth, the term "tissue at depth" as used herein meaning tissue at the border zone of the dermis and hypodermic or subcutaneous region, some of which tissue may be in the lower dermis, mostly at a depth deeper than 1 mm, and tissue below this border zone to a depth of up to about 50 mm The reason why this radiation has not been considered suitable is because such radiation is both highly scattered and highly absorbed in surface layers of tissue, precluding significant portions of such radiation from reaching the tissue regions at depth to cause heating thereof. In view of the energy losses due to scattering and absorption, substantial optical ( including NIR) energy must be applied in order for enough such energy to reach a region of tissues at depth to have a desired effect.
However, such high energy can cause damage to the surface layers of tissue and pain/discomfort to the patient, malting it difficult to achieve desired photothermal treatments in tissue regions at depth. For these reasons, optical radiation has heretofore had at most limited value for therapeutic and cosmetic treatments on tissue at depth.
While heating or cooling of tissue at depth alone has proved useful for many treatments, the combination of heating and cooling applied intermittently to the skin surface (known as contrast therapy) is also known and has been suggested for skin improvement, pain relief, inflammation reduction, and healing of injury. Of particular importance is the application of these techniques for reducing subcutaneous fat deposits and treating cellulite (gynoid lipodystrophy). However, use of cooling or heating, either alone or in combination for treatment of conditions at depth, for example for skin improvement, cellulite improvement, fat reduction, and treatment of other conditions has been limited by the body's pain/discomfort tolerance and by the damage limits of treated organs and adjacent, especially cutaneous, tissue that need to be kept intact.
A need therefore exists for improved method and apparatus for photothermal treatment of tissue regions at depth, and in particular for treatment of deep dermis and subcutaneous regions of tissue, which treatments provide improved treatment results, while both reducing patient pain and discomfort and protecting adjacent and other non-treatment tissue from damage.
SUMMARY OF THE INVENTION
In accordance with the above, this invention provides a method and apparatus for treating at least a selected target region at depth, as this term has previously been defined, of a patient's body, while protecting non-targeted tissue by utilizing a suitable mechanism to cool the patient's skin surface to a temperature below normal body temperature for a selected duration; utilizing a suitable mechanism to selectively apply radiation to the patient's skin above said region before, during and/or after cooling; and repeating the cooling and radiation application for a selected number of cycles, the temperature to which the patient's skin is cooled and the duration of cooling being sufficient to cool the treatment region to a selected temperature below normal body temperature during at least cooling portions of cycles. The cooling duration should be at least about 10 seconds, normally being between approximately 10 seconds and 20 minutes. Where radiation is applied after cooling, the radiation may be applied for approximately one second to 4 minutes. The cooling may be performed continuously while the radiation is applied at intervals during the cooling.
Where the selected region is subcutaneous fat, the selected temperature should be low enough to result in at least a selective phase change of at least a portion of the fat. In this case, the radiation should be of sufficient power and duration and of appropriate wavelength to heat the treatment region to at least a temperature where the phase of the fat cells is altered.
Alternatively, the radiation may be of sufficient power and duration and of appropriate wavelength to heat the treatment region to a temperature where at least one of the biophysical and biochemical characteristics of cells in the region is altered. Alternatively, the radiation should be of sufficient power and duration and of appropriate wavelength to heat tissue above the treatment region to protect the tissue, but not to significantly heat the treatment region. For another embodiment, the treatment involves cycling cooling and heating of the treatment region, radiation being applied after cooling and the radiation being of sufficient power and duration and of appropriate wavelength to heat the region to an appropriate temperature to effect the treatment. For some embodiments, a selected condition of the patient is detected and utilized to control at least a portion of the operation. Stimulation of the selected region may also be utilized before, during and/or after at least one of the operations, such stimulation being generally at least one of mechanical, acoustic and electrical. The period and/or phase of the treatment cycles may be correlated with a sub-circadian rhythm of the patient.
For some embodiments, the radiation is from a continuous wave source and cooling is also performed from a substantially continuously operating source. For these embodiments, cooling and radiation application are each performed by passing an applicator outputting the appropriate source over the patient's overlying the treatment region at a selected rate. The same applicator may be used to perform both cooling ad radiation application for these embodiments and the applicator my perform both operations during the same pass or separate passes.
In accordance with another aspect of the invention, radiation is selectively delivered to the patients body above the selected region to heat the region; patient tissue above the selected region is concurrently cooled to a temperature below that of the selected region; and the region is cooled to a temperature below normal body temperature before and/or after the heating of the region.
In accordance with still another aspect of the invention, treatment is performed by cyclically applying radiation and cooling to the surface of the patient's skin above the selected region through at least one applicator providing substantially continuous cooling/radiation output, which applicator is passed over the patient's skin over the region multiple times for each cooling/radiation cycle.
Other advantages, novel features, and objects of the invention will become apparent from the following detailed description of the invention when considered in conjunction with the accompanying drawings, which are schematic and which are not intended to be drawn to scale. In the figures, each identical, or substantially similar component that is illustrated in various figures is represented by a single numeral or notation. For purposes of clarity, not every component is labeled in every figure, nor is every component of each embodiment of the invention shown where illustration is not necessary to allow those of ordinary skill in the art to understand the invention.
BRIEF DESCRIPTION OF THE DRAWINGS
Non-limiting embodiments of the present invention will be described by way of example with reference to the accompanying drawings in which:
Fig. 1 is a diagram illustrating the temperature/depth profile of the skin and subcutis at various times after the onset of surface cooling;
Fig. 2 is a diagram illustrating temperature in the human body as a function of cooling time for various depths;
Fig. 3 is a diagram illustrating the onset time of patient discomfort and of patient pain as a function of skin surface temperature;
Fig. 4 is a schematic diagram of apparatus suitable for practicing the teachings of this invention;
Figs. Sa-Sd are diagrams illustrating cooling temperature, heating temperature, temperature in an upper layer of the skin and target temperature at depth for successive cooling/heating cycles in a protective mode;
Fig. 6a-6d are diagrams illustrating cooling temperature, heating temperature, temperature in an upper layer of the skin and target temperature at depth for successive cooling/heating cycles in a therapeutic mode;
Fig. 7 is a diagram illustrating the hysterisis of optical transmittance in fat;
Fig. 8a is a cut-away side view of an optical head suitable use in practicing the teachings of the invention;
Fig. 8b is an enlarged cut-away side view of a portion of the head shown in Fig.Ba;
Fig. 9 is a diagram illustrating temperature dynamics at different depth in the skin when in mufti-scan mode using non-selective heating with the applicator shown in Fig. 8; and Fig. 10 is a diagram illustrating temperature dynamics in blood vessels at different depths in the skin in mufti-scan mode using non-selective heating with the applicator shown in Fig. 8.
DETAILED DESCRIPTION
Applications in which the invention may be useful include the treatment of various pathological and cosmetic conditions, particularly skin rejuvenation, wrinkle removal, skin tightening and lifting, reduction of odor production, hair growth control, acne treatment, cellulite and subcutaneous fat treatment, physical therapy, muscle and skeletal treatments, including treatment of spinal cord problems, and treatment of cumulative trauma disorders (CTD's) such as carpel tunnel syndrome (CTS), tendonitis and bursitis, fibromyalgia, lymphedema and cancer therapy.
The application of thermal energy, either heating or cooling, to tissue may also be used, for example, in physical therapy treatments, such as to enhance or accelerate wound healing or relieve pain. Beneficial effects may include a decrease in joint stiffness, an increase in joint extensibility of collagenous structures such as tendons and scar tissue, pain relief, blood-flow changes, or a decrease in muscle spasm and increase in muscle tone. As another example, large protein molecules may have high absorption coefficients, and the heating of protein-rich collagenous tissues may contribute to healing. A wide variety of conditions may be treated using this invention, for example, but not limited to, strained tendons, tenosynovitis, torn ligaments, tendonitis, bursitis, torn joint capsules, or torn muscles. Thermal treatment can be effective on highly metabolic organs such as sebaceous gland, sweat glands and hair follicles.
Other processes may be activated or deactivated within tissue during cooling or heating.
Mechanical or electrical stimulation, such as massage, may also be used in conjunction with cooling or heating to achieve benefits greater then can be achieved by either alone. Positive and negative pressure may also be applied to the skin surface above the treatment region to facilitate the treatment.
In certain embodiments, the present invention may be used for non-invasive or non-destructive reduction of localized fat deposits. For example, the invention may be used to heat fat or adipose cells past their damage temperature, causing cell damage and/or necrosis.
Alternatively, the treated cells may undergo apoptosis, resulting in cell death. The dead cells may then be removed or resorbed into the body, for example, by the body's phagocytic or lymphatic systems. Fat reduction may also be achieved by heating fat or adipose cells to an elevated temperature, but below the damage temperature. For example, the fat cells may be heated to a temperature of between about 41°C and about 45°C.
Under these conditions, applying heat to subcutaneous fat may activate lipases or metabolize lipids contained within the adipose tissue found within the subcutaneous fat layer, or blood flow may increase to the heated area. Additionally, "lipolysis," or the process of breaking down fat in the body, may be regulated by enzymes sensitive to temperature, such as HSL ("hormone-sensitive lipase").
Thus, elevating the temperature of the adipose cells may increase the lipolysis rate, and thus contribute to a reduction in subdermal fat in the area being treated. This temperature can be below the temperature for vascular/lymph damage so damaged fatty cells and fatty acids can be easily removed from the treatment region. Additionally, application of the present invention may be used in combination with other fat-reduction techniques, such as medication, exercise, or adrenergic stimulation The invention also includes cooling of the fat tissue to a temperature below normal body temperature, and preferably below the phase transition temperature of at least some fraction of the lipid content of fatty cells, which temperature is substantially higher then the _7-freezing temperature of water-containing tissue, preceded or preferably followed by heating the fat to a temperature below its damage threshold. Triglycerides (which constitute the largest fraction of lipids in human fatty tissue) undergo a series of phase transitions when their temperature changes from normal body temperature to either a lower or higher temperature.
Specifically, several crystalline forms can exist. These forms are (in the order of increasing stability): a,, [3', and (3. The latter crystals are also significantly larger in size (as needle of a dozen microns length). Crystal formation can be the reason for fatty cell dysfunction and shrinkage resulting from mechanical stress on cell structure and/or destruction of cell metabolism. [3 crystal formation can the primer mechanism for fatty cell treatment. When triglycerides are cooled from normal body temperature, formation of a-crystals takes place. In order to produce more stable forms, (3' first and (3 second, reverse heating of the crystallized triglycerides is required. Further heating leads to complete melting of all crystalline forms.
Therefore, the following process is suggested to initiate formation of (3-crystals in adipose cells. First, the fatty tissue is cooled to a lower-than-normal temperature Ta (in the range between 0 and 37 C). This results in a-crystals being formed. Then, the tissue is heated back to a temperature Tp> Ta but below 37 C, causing formation of ~3'- and [3-crystals.
Finally, the tissue can be heated to even higher temperature in order to melt the crystals, and the process can be repeated for a selected number of cycles. The expected final result is dystrophy and decrease in volume of fatty tissue. This process takes place for all temperature range 0-37 but for lower Ta this process is more effective. Thermal activation of lymph systems in subcutaneous fat can also be used to treat cellulite by removing proteins from extra cell spaces.
Application of a cooling panel (agent or device) to the skin surface causes the temperature of skin and the subcutaneous region or subcutis to drop gradually, as illustrated by Fig.l. In Fig. l, curve (1) is after one minute, curve (2) after five minutes, curve (3) after ten minutes, and curve (4) after thirty minutes of application of a cooling panel to the skin surface.
The depth of the slcin/fat or dermis/subcutaneous boundary, shown at 3mm in Fig. 1, will vary depending on a number of factors including the patient and the portion of the patient's body being treated. The rate of cooling and the final temperature depend on the depth of the target and the temperature of the skin surface. Figure 2 shows the calculated temperature dynamics of the dermis-subcutis junction at 2.5 mm depth and in subcutaneous fat at 7.5 mm depth resulting from a constant surface temperature of 0°C. Substantial cooling of targets in the skin _g_ can be achieved in the time range between 10 s and 300 s. Deeper targets in subcutaneous fat need cooling times in the range between 2 min and 30 min. Cooling time can be shortened by simultaneously coupling into the skin pressure or acoustic waves or by intensive massage of cooled skin. The acoustic waves or mechanical massage can increase the heat conductivity of the skin and subcutaneous fat by forced convection of inter-cellular water.
Depending on the surface temperature and the duration of application, a number of processes can be initiated in the fatty and other tissues, including, but not limited to:
~ Phase transitions in lipids;
~ Changes in regulatory functions of the adipocyte. In particular, lower temperatures may suppress activity of Alpha2 receptors, which inhibit adenylate cyclase and cyclic AMP through Gi protein and thus decrease lypolisis rate. This can lead to long-term atrophy of fatty cells after cold exposure;
~ Increase of ion concentration in intracellular water. Such an increase is caused by partial binding of free water in the course of fat crystallization. Transition of water into bound state has been demonstrated spectroscopically. As a result, concentration of ions in the remaining free water increases. Once the ion concentration exceeds a critical level, irreversible damage to the vital mechanisms of the cell can occur;
~ Water crystallization in tissues;
~ Induction of apoptosis;
~ Tissue necrosis;
~ Stimulation of thermogenesis ~ Remodeling of vascular and lymph vessels;
~ Temporal or permanent dysfunction of follicles, sebaceous and sweat glands.
In practical use, cold exposure time is limited by the onset of unpleasant and, subsequently, painful sensations. Fig. 3 illustrates the dependence of these onset times on the temperature at the slcin surface. As a result, the practical application time may be insufficient to achieve a desired therapeutic effect.
Thermal cycling, comprised of cooling and heating phases, may be used to eliminate both the pain/discomfort and unwanted tissue damage outside the target region.
It should be emphasized that, although methods and devices alternating skin surface temperature between hot and cold have previously been proposed, the thermal inertia of tissue prevents rapid propagation of a heat front from the slcin surface to a desired treatment depth (or vice versa).
This invention therefore uses deep-penetrating electromagnetic or acoustic radiation to create distributed heat sources within tissue. This allows increasing the treatment time substantially and achieving acceptable therapeutic effect, while maintaining both complete non-invasiveness of the procedure and patient comfort.
Beneficial effects of thermal cycling are not limited to treatment of fatty tissue.
Thermal cycling initiates a number of biophysical and biochemical responses at molecular, cellular, tissue, and organ levels, including (but not limited to):
~ modulation of cell membrane's permeability and, therefore, inter-membrane transport and exchange between intra- and interstitial compartments;
~ induction of thermo-mechanical stress in the target (for example, malignant) cells, leading to cell death through either necrosis or apoptosis;
~ changes in elasticity and permeability of vessel walls;
~ changes in blood rheology;
~ stimulation of tissue regeneration, including new collagen generation in skin and subcutis;
~ changes of toxin structure in the interstitial fluid makingthem amenable for easy removal by lymphatic systems.
As a result, thermal cycling can be used for.treatment of a wide range of conditions, involving slcin, subcutaneous fat, connective tissues, blood and lymph vasculature, muscles, bones, and other internal organs.
Apparatus for implementing the technical concept is illustrated by Fig.4. This implementation is exemplary, and a suitable configuration can be easily derived by those skilled in the art for particular applications. The cooling unit can be a thermoelectric element, an enclosure with cooling agent, a stream of cold gas (or liquid) or other cooling unit known in the art. Phase-changing materials can also be used for cooling. Preferably, skin surface temperature during the cooling phase should be maintained within the range between 0 C and 25 C. Preferable tissue temperature on the heating phase is in the range between 25 C and 45 C. In one embodiment of the invention, optical radiation is used on the heating phase of the cycle. In this embodiment, the energy source can be a laser, an LED, a lamp (discharge, halogen or other), or a combination or an array thereof. The spectral composition of the source can be either narrow- or broad-band, with the range of wavelengths between 400 nm and 2000 nm. Spectral filtration can be used for further modifying spectral composition of the beam in order to achieve optimal penetration. The wavelengths used for a particular application will depend on the target tissue, the depth of the tissue and other factors. The light source is operated preferably in the continuous wave (CW) mode, with a preferred irradiance at the skin surface in the range between 0.1 and 100 W/cm2. The thermal cycle is organized in such a way as to maximize efficacy of treatment. Typically, duration of the cooling phase can be between 10 sec and 30 min, whereas duration of the heating phase can be between 1 sec and 4 min. The apparatus of Fig. 4 also includes a power supply for the energy source, a suitable control unit, an optional sensor, the function of which will be discussed later, and other components normally used in such apparatus.
The invention can be practiced in two distinctive modes (See Figs. 5 and 6):
in the protective mode, thermal cycling is used to protect adjacent (typically, upper) tissue from unwanted damage; whereas in the therapeutic mode thermal cycling is used substantially as a treatment modality.
The invention can be practiced in at least two distinct modes (See Figs. 5 and 6). In the protective mode of Fig. 5, initially applied cooling rapidly lowers the temperature at the skin surface, the target region and all tissue therebetween. Before the patient experiences pain or discomfort, and before thermal damage occurs outside the target region, a heating phase is initiated. The radiation from the energy source is sufficient to raise the temperature at the skin surface and below to a depth above the treatment region to a temperature above a discomfort or damage temperature, but has little effect on the treatment region at depth.
This results in the temperature of the treatment region continuing to drop slightly with successive cooling cycles.
This mode of thermal cycling is thus used to protect adjacent (typically, upper) tissue from unwanted damage. In the therapeutic mode shown in Fig. 6, thermal cycling is used substantially as a treatment modality. Here, the cooling and radiation parameters are selected so that, during heating cycles, the temperature at both the surface and the treatment region rise above normal body temperature, the treatment region thus being cycled between cold therapy and heat therapy. While in Fig. 6, the target region is heated above normal body temperature during heating portions of each cycle, this is not a limitation on the invention, and cyclically heating the target region to a selected temperature below normal body temperature may also have therapeutic effect for some conditions. Cycling may also be practiced by heating the target region to a temperature sufficient to cause hyperthermia, for example 42 to 47°C, either with or without simultaneous cooling to protect overlying tissue, and then either reducing or removing the radiation or increasing cooling to cool the treatment region below normal body temperature, this being done cyclically.
Thermal cycling offers another advantage when optical radiation is used as the deep-penetrating energy. Specifically, it has been demonstrated with optical measurements, that the rate of increase in optical transmittance when fresh human fatty tissue is heated exceeds the rate of decrease in optical transmittance when the same tissue is cooled (See Fig.7). There is an indication of accumulated irreversible structural change in the fatty tissue caused by thermal cycling in relatively narrow temperature ranges between 25 and 30 C. As a consequence, the penetration depth of the optical radiation (and the efficiency of the heating phase) can be augmented by multiple cycling.
In some embodiments, the applicator (handpiece) of the apparatus can be realized as a stationary implement, which is placed on the treatment area prior to initiating thermal cycling.
In other embodiments, the handpiece can be manually or mechanically scanned along the skin surface (See Fig. 8). Thermal cycling can be performed concurrently with scanning.
Alternatively, thermal cycling can be implemented by performing at least one (preferably, several) passes on the cooling phase, followed by at least one (preferably, several) passes on the heating phase, and repeating the cycle until desired treatment effect is achieved. Referring to Fig.Ba, an exemplary scanning handpiece is shown which includes a handle 1 and an applicator 2. Referring to Fig 8b, the applicator 2 includes a mount 3, a reflector cooling fan 4, an optional pressure or acoustic generator, vibrator ormassaging implement 5, a reflector 6, a radiation source (an arc or halogen lamp for the embodiment shown) 7, a cooling plate 8, an optional wheel 9 functioning as a mechanical velocity sensor, a cooling agent 10 and an optical filter 11.
The apparatus of Fig. 8 can be used, in particular, in a mufti-scan mode. The multi-scan mode results in non-uniform cycling of temperature at different depths.
Figure 9 shows temperature at the epidermis/dermis junction (0.1 mm depth), dermis/
hypodermis junction (2.5 mm depth) and subcutaneous fat (7.5 mm depth) as a function of time for mufti-scan operation.
Calculations have been done for the following conditions: wavelength 800-1800 nm (filtered spectrum of halogen lamp), power density 80 W/cm2, width of optical beam across scanning direction is 1 cm, speed of scan is 10 cm/s, length of scan is 50 cm, temperature of cold sapphire window in contact with the skin is -10°C. For scanning mode, the temperature of the contact plate can be significantly lower than the skin freezing temperature and at fast scanning speeds (about 10 cm/s), can be as low as -50°C without risk of cold injury. Figure 9 shows that the amplitude of thermal oscillations decreases with depth in skin. However, the time of stabilization of the temperature for deep targets can be long: 0.1 mm - 100 s or 10 scans, 2.5 mm - 5 min or 30 scans, 7.5 mm - 15 min or 90 scans.
Figure 10 shows temperatures at the blood vessels in first plexus ( 0.015 mm diameter , 0.1 mm depth), second plexus ( 0.2 mm diameter, 2.5 mm depth), and subcutaneous fat ( 0.1 mm diameter, 7.5 mm depth) as a function of time for multi-scan operation.
Calculations have been done for the following conditions: wavelength 400-1800 nm (filtered spectrum of halogen lamp), power density 65 W/cm2, width of optical beam across scanning direction is 1 cm, speed of scan is 10 cm/s, length of scan is 50 cm, temperature of cold sapphire window in contact with the skin is -10°C. Figure 10 shows that the amplitude of thermal oscillations in blood vessels is significant in the skin and negligible in the subcutaneous fat. Large temperature oscillations at the vessels in the second plexus ( up to 10 °C) can be effective for treatment of various conditions at the deep dermis and dermis/hypodennis junction and for improvement of cosmetic appearance of cellulite. Since the temperature of vessels in the subcutaneous fat is continuously rising, this treatment can be effective for increasing the rate of lypolysis.
Where energy source is a continuous wave (CW) or other long duration source, the apparatus or device for various of the embodiments may be slid or scanned over the surface of the patient's skin to overlie successive treatment regions, the dwell time, and thus the treatment duration, for each such region being a function of the rate at which the device is moved. The device may be moved over each treatment region multiple times during a single treatment.
Since the device will typically also include a skin cooling mechanism, concurrent heating and cooling is effected for each region as the device passes thereover. The device may also include a cooling mechanism ahead of the portion of the device under the energy source to pre-cool skin above the treatment region (see for example issued U.S. Patents Nos.
6,273,884 and 6,511,475, which are incorporated herein by reference). The power density PS
for this sliding mode of operation is:
PS= Po T v/d, Were 'Po is power density for the organ/region being treated in a stationary mode V is speed of sliding, d is spot or aperture size in the direction of scanning, T is interval between two consecutive passes through same spot.
Treatment time is TS = To T v/d, where To is the stationary mode treatment time for the organ/region being treated In order for the multiple passes to be beneficial, T should be less than the thermal relaxation time of the tissue being treated in the region at depth. However, when in either stationary mode or sliding mode, the treatment time can be greater than the thermal relaxation time of the tissue being treated.
Any of the embodiments can include a contact sensor to assure good optical and thermal coupling, and systems operating in the sliding mode may also include one or more motion sensors to control radiation delivery, cooling and other functions dependent on scanning speed, to enhance system safety and for other reasons.
In addition to coupling the deep heating treatment of this invention with deep cooling to enhance treatment of fat, bone, muscle, etc., the applicator may also include a massager, vibrator or other mechanical stimulation device, an ultrasonic or other acoustic stimulator or a DC or other suitable electrical stimulation source. It has been found that such mechanical or electrical stimulation is more effective when tissue temperature deviates from normal body temperature (ie., for hot or cold tissue). Similarly, the effect of deep heating may be enhanced by massage or other stimulation because both heat and cold generally penetrates better in compressed skin and subdermal tissue. Thus, the combination of deep heating and mechanical or electrical stimulation may provide significantly better results then either one alone. Heating may also be enhanced by supplementing the optical heating with, for example electro-stimulation by AC/DC, or additional heating by RF, etc. Tensioning or pressure applied to the skin overlying the treatment region may also enhance treatment effect and decrease patient discomfort/pain sensation.
While an optical radiation source has been utilized for preferred embodiments, other forms of electromagnetic radiation such as microwave or radio frequency radiation can be used on the heating phase of the cycle. Alternatively, acoustic energy can be used. Unless otherwise indicated, the term radiation, as used herein, shall refer to the output from all such sources. The power of the source utilized should be selected in order to maintain the temperature of the targeted tissue within the preferred range.
The effectiveness of the invention may also be further increased by practicing a thennotolerance regimen. In this mode, the magnitude of temperature deviations from normal skin surface temperature which a patient can tolerate increases gradually from cycle to cycle, permitting treatment temperatures, and thus treatment effectiveness to also be gradually increased from cycle to cycle. This mode allows further increasing protection of cutaneous tissues from unwanted damage.
It may also be possible to correlate the period and phase of the thermal cycle with sub-circadian biological rhythms of the patient. Such combination can further optimize treatment results by using naturally occurring oscillations of biochemical activity in cutaneous and subcutaneous tissues. Furthermore, the temporal structure of the thermal cycling can deviate from simple harmonic oscillations and be comprised, for example, of several, or even an infinite number of harmonics.
In certain embodiments, the cooling implement can be realized as a layer (film, wrap) placed over the treatment region and the irradiating applicator can be realized as a head scanned on top of the cooling implement. Thermal cycling is achieved as a result of multiple passes of the irradiating applicator.
Some embodiments of the invention can incorporate a feedback loop between the applicator and the control unit. The feedback loop can incorporate a single or multiple sensors registering the state of the apparatus and the treatment area. For example, a thermal sensor can be used to initiate the heating phase of the cycle when tissue temperature drops below a certain threshold, and initiate the cooling phase of the cycle when the temperature exceeds another threshold. Other sensor types include, but are not limited to, scanning speed sensors, contact sensors, pressure sensors, skin detectors, and skin response sensors.
In some embodiments of the invention, an additional stimulating implement can be integrated into the applicator (see Fig. 8b). The purpose of the implement is to optimize tissue structure and facilitate thermal cycling. The implement can be, for example, mechanical (lcnitting, rolling, or pulling action) or vacuum (negative/positive pressure in the treatment area). Other forms of tissue stimulation may also be utilized, for example, ultrasonic or other acoustic stimulation, or electrical stimulation.
While several embodiments of the invention have been described and illustrated herein, those of ordinary skill in the art will readily envision a variety of other means and structures for performing the functions and/or obtaining the results and/or advantages described herein, and each of such variations or modifications is deemed to be within the scope of the present invention. More generally, those skilled in the art would readily appreciate that all parameters, dimensions, materials, and configurations described herein are meant to be exemplary and that actual parameters, dimensions, materials, and configurations will depend upon specific applications for which the teachings of the present invention are used. Those skilled in the art will recognize, or be able to ascertain using no more than routine experimentation, many equivalents to the specific embodiments of the invention described herein. It is, therefore, to be understood that the foregoing embodiments are presented by way of example only and that, within the scope of the appended claims and equivalents thereto, the invention may be practiced otherwise than as specifically described. The present invention is directed to each individual feature, system, material and/or method described herein. In addition, any combination of two or more such features, systems, materials and/or methods, if such features, systems, materials and/or methods are not mutually inconsistent, is included within the scope of the present invention. In the claims, all transitional phrases or phrases of inclusion, such as "comprising," "including," "carrying," "having," "containing," and the like are to be understood to be open-ended, i.e. to mean "including but not limited to." Only the transitional phrases or phrases of inclusion "consisting of and "consisting essentially of are to be interpreted as closed or semi-closed phrases, respectively.
What is claimed is:
TREATMENT OF CUTANEOUS AND SUBCUTANEOUS CONDITIONS
CROSS-REFERENCE TO RELATED APPLICATION
This invention claims the benefit of co-pending U.S. Provisional Patent Application Serial No. 60/389,871, filed June 19, 2002, entitled "Method and Apparatus for Subdermal Heating," by G. Altshuler, et al., incorporated herein by reference in its entirety.
BACKGROUND
Field of the Invention This invention relates to methods and apparatus for the photothermal treatment of tissue and, more particularly, to methods and apparatus for treating cutaneous and subcutaneous conditions at depth.
Description of the Related Art The benefits of being able to raise and/or lower the temperature in a selected region of tissue for various therapeutic and cosmetic purposes has been known for some time. For instance, heated pads or plates or various forms of electromagnetic radiation, including visible, infrared and microwave radiation, electricity,and ultrasound have previously been used for heating subdermal muscles, ligaments, bones and the like to, for example, increase blood flow, to otherwise promote the healing of various injuries and other damage, and for various therapeutic purposes, such as frostbite or hyperthermia treatment, treatment of poor blood circulation, physical therapy, stimulation of collagen, cellulite treatment, adrenergic stimulation, wound healing, psoriasis treatment, body reshaping, non-invasive wrinkle removal, etc. The heating of tissues has also been utilized as a potential treatment for removing cancers or other undesired growths, infections and the like. Heating may be applied over a small localized area, over a larger area, for example to the hands or feet, or over larger regions of tissue, including the entire body.
Since most of the techniques described above involve applying energy to tissue at depth through the patient's skin surface, peak temperature generally occurs at or near the patient's skin surface and decrease, sometimes significantly, with depth. Further, while microwaves or ultrasonic and other acoustic radiation have been used in the past, such radiation has had _2_ limited use because, particularly for microwaves, they may be potentially mutagenic, may potentially otherwise result in cell or systemic damage and, particularly for acoustic sources, are relatively expensive.They may also not be practical for large-area treatment.
While optical and near infrared (NIR) radiation ( collectively referred to hereinafter as "optical radiation" is generally both less expensive and, being non-mutagenic, safer than microwaves radiation, the use of optical radiation has heretofore not been considered suitable for most applications involving heating of tissue at depth, the term "tissue at depth" as used herein meaning tissue at the border zone of the dermis and hypodermic or subcutaneous region, some of which tissue may be in the lower dermis, mostly at a depth deeper than 1 mm, and tissue below this border zone to a depth of up to about 50 mm The reason why this radiation has not been considered suitable is because such radiation is both highly scattered and highly absorbed in surface layers of tissue, precluding significant portions of such radiation from reaching the tissue regions at depth to cause heating thereof. In view of the energy losses due to scattering and absorption, substantial optical ( including NIR) energy must be applied in order for enough such energy to reach a region of tissues at depth to have a desired effect.
However, such high energy can cause damage to the surface layers of tissue and pain/discomfort to the patient, malting it difficult to achieve desired photothermal treatments in tissue regions at depth. For these reasons, optical radiation has heretofore had at most limited value for therapeutic and cosmetic treatments on tissue at depth.
While heating or cooling of tissue at depth alone has proved useful for many treatments, the combination of heating and cooling applied intermittently to the skin surface (known as contrast therapy) is also known and has been suggested for skin improvement, pain relief, inflammation reduction, and healing of injury. Of particular importance is the application of these techniques for reducing subcutaneous fat deposits and treating cellulite (gynoid lipodystrophy). However, use of cooling or heating, either alone or in combination for treatment of conditions at depth, for example for skin improvement, cellulite improvement, fat reduction, and treatment of other conditions has been limited by the body's pain/discomfort tolerance and by the damage limits of treated organs and adjacent, especially cutaneous, tissue that need to be kept intact.
A need therefore exists for improved method and apparatus for photothermal treatment of tissue regions at depth, and in particular for treatment of deep dermis and subcutaneous regions of tissue, which treatments provide improved treatment results, while both reducing patient pain and discomfort and protecting adjacent and other non-treatment tissue from damage.
SUMMARY OF THE INVENTION
In accordance with the above, this invention provides a method and apparatus for treating at least a selected target region at depth, as this term has previously been defined, of a patient's body, while protecting non-targeted tissue by utilizing a suitable mechanism to cool the patient's skin surface to a temperature below normal body temperature for a selected duration; utilizing a suitable mechanism to selectively apply radiation to the patient's skin above said region before, during and/or after cooling; and repeating the cooling and radiation application for a selected number of cycles, the temperature to which the patient's skin is cooled and the duration of cooling being sufficient to cool the treatment region to a selected temperature below normal body temperature during at least cooling portions of cycles. The cooling duration should be at least about 10 seconds, normally being between approximately 10 seconds and 20 minutes. Where radiation is applied after cooling, the radiation may be applied for approximately one second to 4 minutes. The cooling may be performed continuously while the radiation is applied at intervals during the cooling.
Where the selected region is subcutaneous fat, the selected temperature should be low enough to result in at least a selective phase change of at least a portion of the fat. In this case, the radiation should be of sufficient power and duration and of appropriate wavelength to heat the treatment region to at least a temperature where the phase of the fat cells is altered.
Alternatively, the radiation may be of sufficient power and duration and of appropriate wavelength to heat the treatment region to a temperature where at least one of the biophysical and biochemical characteristics of cells in the region is altered. Alternatively, the radiation should be of sufficient power and duration and of appropriate wavelength to heat tissue above the treatment region to protect the tissue, but not to significantly heat the treatment region. For another embodiment, the treatment involves cycling cooling and heating of the treatment region, radiation being applied after cooling and the radiation being of sufficient power and duration and of appropriate wavelength to heat the region to an appropriate temperature to effect the treatment. For some embodiments, a selected condition of the patient is detected and utilized to control at least a portion of the operation. Stimulation of the selected region may also be utilized before, during and/or after at least one of the operations, such stimulation being generally at least one of mechanical, acoustic and electrical. The period and/or phase of the treatment cycles may be correlated with a sub-circadian rhythm of the patient.
For some embodiments, the radiation is from a continuous wave source and cooling is also performed from a substantially continuously operating source. For these embodiments, cooling and radiation application are each performed by passing an applicator outputting the appropriate source over the patient's overlying the treatment region at a selected rate. The same applicator may be used to perform both cooling ad radiation application for these embodiments and the applicator my perform both operations during the same pass or separate passes.
In accordance with another aspect of the invention, radiation is selectively delivered to the patients body above the selected region to heat the region; patient tissue above the selected region is concurrently cooled to a temperature below that of the selected region; and the region is cooled to a temperature below normal body temperature before and/or after the heating of the region.
In accordance with still another aspect of the invention, treatment is performed by cyclically applying radiation and cooling to the surface of the patient's skin above the selected region through at least one applicator providing substantially continuous cooling/radiation output, which applicator is passed over the patient's skin over the region multiple times for each cooling/radiation cycle.
Other advantages, novel features, and objects of the invention will become apparent from the following detailed description of the invention when considered in conjunction with the accompanying drawings, which are schematic and which are not intended to be drawn to scale. In the figures, each identical, or substantially similar component that is illustrated in various figures is represented by a single numeral or notation. For purposes of clarity, not every component is labeled in every figure, nor is every component of each embodiment of the invention shown where illustration is not necessary to allow those of ordinary skill in the art to understand the invention.
BRIEF DESCRIPTION OF THE DRAWINGS
Non-limiting embodiments of the present invention will be described by way of example with reference to the accompanying drawings in which:
Fig. 1 is a diagram illustrating the temperature/depth profile of the skin and subcutis at various times after the onset of surface cooling;
Fig. 2 is a diagram illustrating temperature in the human body as a function of cooling time for various depths;
Fig. 3 is a diagram illustrating the onset time of patient discomfort and of patient pain as a function of skin surface temperature;
Fig. 4 is a schematic diagram of apparatus suitable for practicing the teachings of this invention;
Figs. Sa-Sd are diagrams illustrating cooling temperature, heating temperature, temperature in an upper layer of the skin and target temperature at depth for successive cooling/heating cycles in a protective mode;
Fig. 6a-6d are diagrams illustrating cooling temperature, heating temperature, temperature in an upper layer of the skin and target temperature at depth for successive cooling/heating cycles in a therapeutic mode;
Fig. 7 is a diagram illustrating the hysterisis of optical transmittance in fat;
Fig. 8a is a cut-away side view of an optical head suitable use in practicing the teachings of the invention;
Fig. 8b is an enlarged cut-away side view of a portion of the head shown in Fig.Ba;
Fig. 9 is a diagram illustrating temperature dynamics at different depth in the skin when in mufti-scan mode using non-selective heating with the applicator shown in Fig. 8; and Fig. 10 is a diagram illustrating temperature dynamics in blood vessels at different depths in the skin in mufti-scan mode using non-selective heating with the applicator shown in Fig. 8.
DETAILED DESCRIPTION
Applications in which the invention may be useful include the treatment of various pathological and cosmetic conditions, particularly skin rejuvenation, wrinkle removal, skin tightening and lifting, reduction of odor production, hair growth control, acne treatment, cellulite and subcutaneous fat treatment, physical therapy, muscle and skeletal treatments, including treatment of spinal cord problems, and treatment of cumulative trauma disorders (CTD's) such as carpel tunnel syndrome (CTS), tendonitis and bursitis, fibromyalgia, lymphedema and cancer therapy.
The application of thermal energy, either heating or cooling, to tissue may also be used, for example, in physical therapy treatments, such as to enhance or accelerate wound healing or relieve pain. Beneficial effects may include a decrease in joint stiffness, an increase in joint extensibility of collagenous structures such as tendons and scar tissue, pain relief, blood-flow changes, or a decrease in muscle spasm and increase in muscle tone. As another example, large protein molecules may have high absorption coefficients, and the heating of protein-rich collagenous tissues may contribute to healing. A wide variety of conditions may be treated using this invention, for example, but not limited to, strained tendons, tenosynovitis, torn ligaments, tendonitis, bursitis, torn joint capsules, or torn muscles. Thermal treatment can be effective on highly metabolic organs such as sebaceous gland, sweat glands and hair follicles.
Other processes may be activated or deactivated within tissue during cooling or heating.
Mechanical or electrical stimulation, such as massage, may also be used in conjunction with cooling or heating to achieve benefits greater then can be achieved by either alone. Positive and negative pressure may also be applied to the skin surface above the treatment region to facilitate the treatment.
In certain embodiments, the present invention may be used for non-invasive or non-destructive reduction of localized fat deposits. For example, the invention may be used to heat fat or adipose cells past their damage temperature, causing cell damage and/or necrosis.
Alternatively, the treated cells may undergo apoptosis, resulting in cell death. The dead cells may then be removed or resorbed into the body, for example, by the body's phagocytic or lymphatic systems. Fat reduction may also be achieved by heating fat or adipose cells to an elevated temperature, but below the damage temperature. For example, the fat cells may be heated to a temperature of between about 41°C and about 45°C.
Under these conditions, applying heat to subcutaneous fat may activate lipases or metabolize lipids contained within the adipose tissue found within the subcutaneous fat layer, or blood flow may increase to the heated area. Additionally, "lipolysis," or the process of breaking down fat in the body, may be regulated by enzymes sensitive to temperature, such as HSL ("hormone-sensitive lipase").
Thus, elevating the temperature of the adipose cells may increase the lipolysis rate, and thus contribute to a reduction in subdermal fat in the area being treated. This temperature can be below the temperature for vascular/lymph damage so damaged fatty cells and fatty acids can be easily removed from the treatment region. Additionally, application of the present invention may be used in combination with other fat-reduction techniques, such as medication, exercise, or adrenergic stimulation The invention also includes cooling of the fat tissue to a temperature below normal body temperature, and preferably below the phase transition temperature of at least some fraction of the lipid content of fatty cells, which temperature is substantially higher then the _7-freezing temperature of water-containing tissue, preceded or preferably followed by heating the fat to a temperature below its damage threshold. Triglycerides (which constitute the largest fraction of lipids in human fatty tissue) undergo a series of phase transitions when their temperature changes from normal body temperature to either a lower or higher temperature.
Specifically, several crystalline forms can exist. These forms are (in the order of increasing stability): a,, [3', and (3. The latter crystals are also significantly larger in size (as needle of a dozen microns length). Crystal formation can be the reason for fatty cell dysfunction and shrinkage resulting from mechanical stress on cell structure and/or destruction of cell metabolism. [3 crystal formation can the primer mechanism for fatty cell treatment. When triglycerides are cooled from normal body temperature, formation of a-crystals takes place. In order to produce more stable forms, (3' first and (3 second, reverse heating of the crystallized triglycerides is required. Further heating leads to complete melting of all crystalline forms.
Therefore, the following process is suggested to initiate formation of (3-crystals in adipose cells. First, the fatty tissue is cooled to a lower-than-normal temperature Ta (in the range between 0 and 37 C). This results in a-crystals being formed. Then, the tissue is heated back to a temperature Tp> Ta but below 37 C, causing formation of ~3'- and [3-crystals.
Finally, the tissue can be heated to even higher temperature in order to melt the crystals, and the process can be repeated for a selected number of cycles. The expected final result is dystrophy and decrease in volume of fatty tissue. This process takes place for all temperature range 0-37 but for lower Ta this process is more effective. Thermal activation of lymph systems in subcutaneous fat can also be used to treat cellulite by removing proteins from extra cell spaces.
Application of a cooling panel (agent or device) to the skin surface causes the temperature of skin and the subcutaneous region or subcutis to drop gradually, as illustrated by Fig.l. In Fig. l, curve (1) is after one minute, curve (2) after five minutes, curve (3) after ten minutes, and curve (4) after thirty minutes of application of a cooling panel to the skin surface.
The depth of the slcin/fat or dermis/subcutaneous boundary, shown at 3mm in Fig. 1, will vary depending on a number of factors including the patient and the portion of the patient's body being treated. The rate of cooling and the final temperature depend on the depth of the target and the temperature of the skin surface. Figure 2 shows the calculated temperature dynamics of the dermis-subcutis junction at 2.5 mm depth and in subcutaneous fat at 7.5 mm depth resulting from a constant surface temperature of 0°C. Substantial cooling of targets in the skin _g_ can be achieved in the time range between 10 s and 300 s. Deeper targets in subcutaneous fat need cooling times in the range between 2 min and 30 min. Cooling time can be shortened by simultaneously coupling into the skin pressure or acoustic waves or by intensive massage of cooled skin. The acoustic waves or mechanical massage can increase the heat conductivity of the skin and subcutaneous fat by forced convection of inter-cellular water.
Depending on the surface temperature and the duration of application, a number of processes can be initiated in the fatty and other tissues, including, but not limited to:
~ Phase transitions in lipids;
~ Changes in regulatory functions of the adipocyte. In particular, lower temperatures may suppress activity of Alpha2 receptors, which inhibit adenylate cyclase and cyclic AMP through Gi protein and thus decrease lypolisis rate. This can lead to long-term atrophy of fatty cells after cold exposure;
~ Increase of ion concentration in intracellular water. Such an increase is caused by partial binding of free water in the course of fat crystallization. Transition of water into bound state has been demonstrated spectroscopically. As a result, concentration of ions in the remaining free water increases. Once the ion concentration exceeds a critical level, irreversible damage to the vital mechanisms of the cell can occur;
~ Water crystallization in tissues;
~ Induction of apoptosis;
~ Tissue necrosis;
~ Stimulation of thermogenesis ~ Remodeling of vascular and lymph vessels;
~ Temporal or permanent dysfunction of follicles, sebaceous and sweat glands.
In practical use, cold exposure time is limited by the onset of unpleasant and, subsequently, painful sensations. Fig. 3 illustrates the dependence of these onset times on the temperature at the slcin surface. As a result, the practical application time may be insufficient to achieve a desired therapeutic effect.
Thermal cycling, comprised of cooling and heating phases, may be used to eliminate both the pain/discomfort and unwanted tissue damage outside the target region.
It should be emphasized that, although methods and devices alternating skin surface temperature between hot and cold have previously been proposed, the thermal inertia of tissue prevents rapid propagation of a heat front from the slcin surface to a desired treatment depth (or vice versa).
This invention therefore uses deep-penetrating electromagnetic or acoustic radiation to create distributed heat sources within tissue. This allows increasing the treatment time substantially and achieving acceptable therapeutic effect, while maintaining both complete non-invasiveness of the procedure and patient comfort.
Beneficial effects of thermal cycling are not limited to treatment of fatty tissue.
Thermal cycling initiates a number of biophysical and biochemical responses at molecular, cellular, tissue, and organ levels, including (but not limited to):
~ modulation of cell membrane's permeability and, therefore, inter-membrane transport and exchange between intra- and interstitial compartments;
~ induction of thermo-mechanical stress in the target (for example, malignant) cells, leading to cell death through either necrosis or apoptosis;
~ changes in elasticity and permeability of vessel walls;
~ changes in blood rheology;
~ stimulation of tissue regeneration, including new collagen generation in skin and subcutis;
~ changes of toxin structure in the interstitial fluid makingthem amenable for easy removal by lymphatic systems.
As a result, thermal cycling can be used for.treatment of a wide range of conditions, involving slcin, subcutaneous fat, connective tissues, blood and lymph vasculature, muscles, bones, and other internal organs.
Apparatus for implementing the technical concept is illustrated by Fig.4. This implementation is exemplary, and a suitable configuration can be easily derived by those skilled in the art for particular applications. The cooling unit can be a thermoelectric element, an enclosure with cooling agent, a stream of cold gas (or liquid) or other cooling unit known in the art. Phase-changing materials can also be used for cooling. Preferably, skin surface temperature during the cooling phase should be maintained within the range between 0 C and 25 C. Preferable tissue temperature on the heating phase is in the range between 25 C and 45 C. In one embodiment of the invention, optical radiation is used on the heating phase of the cycle. In this embodiment, the energy source can be a laser, an LED, a lamp (discharge, halogen or other), or a combination or an array thereof. The spectral composition of the source can be either narrow- or broad-band, with the range of wavelengths between 400 nm and 2000 nm. Spectral filtration can be used for further modifying spectral composition of the beam in order to achieve optimal penetration. The wavelengths used for a particular application will depend on the target tissue, the depth of the tissue and other factors. The light source is operated preferably in the continuous wave (CW) mode, with a preferred irradiance at the skin surface in the range between 0.1 and 100 W/cm2. The thermal cycle is organized in such a way as to maximize efficacy of treatment. Typically, duration of the cooling phase can be between 10 sec and 30 min, whereas duration of the heating phase can be between 1 sec and 4 min. The apparatus of Fig. 4 also includes a power supply for the energy source, a suitable control unit, an optional sensor, the function of which will be discussed later, and other components normally used in such apparatus.
The invention can be practiced in two distinctive modes (See Figs. 5 and 6):
in the protective mode, thermal cycling is used to protect adjacent (typically, upper) tissue from unwanted damage; whereas in the therapeutic mode thermal cycling is used substantially as a treatment modality.
The invention can be practiced in at least two distinct modes (See Figs. 5 and 6). In the protective mode of Fig. 5, initially applied cooling rapidly lowers the temperature at the skin surface, the target region and all tissue therebetween. Before the patient experiences pain or discomfort, and before thermal damage occurs outside the target region, a heating phase is initiated. The radiation from the energy source is sufficient to raise the temperature at the skin surface and below to a depth above the treatment region to a temperature above a discomfort or damage temperature, but has little effect on the treatment region at depth.
This results in the temperature of the treatment region continuing to drop slightly with successive cooling cycles.
This mode of thermal cycling is thus used to protect adjacent (typically, upper) tissue from unwanted damage. In the therapeutic mode shown in Fig. 6, thermal cycling is used substantially as a treatment modality. Here, the cooling and radiation parameters are selected so that, during heating cycles, the temperature at both the surface and the treatment region rise above normal body temperature, the treatment region thus being cycled between cold therapy and heat therapy. While in Fig. 6, the target region is heated above normal body temperature during heating portions of each cycle, this is not a limitation on the invention, and cyclically heating the target region to a selected temperature below normal body temperature may also have therapeutic effect for some conditions. Cycling may also be practiced by heating the target region to a temperature sufficient to cause hyperthermia, for example 42 to 47°C, either with or without simultaneous cooling to protect overlying tissue, and then either reducing or removing the radiation or increasing cooling to cool the treatment region below normal body temperature, this being done cyclically.
Thermal cycling offers another advantage when optical radiation is used as the deep-penetrating energy. Specifically, it has been demonstrated with optical measurements, that the rate of increase in optical transmittance when fresh human fatty tissue is heated exceeds the rate of decrease in optical transmittance when the same tissue is cooled (See Fig.7). There is an indication of accumulated irreversible structural change in the fatty tissue caused by thermal cycling in relatively narrow temperature ranges between 25 and 30 C. As a consequence, the penetration depth of the optical radiation (and the efficiency of the heating phase) can be augmented by multiple cycling.
In some embodiments, the applicator (handpiece) of the apparatus can be realized as a stationary implement, which is placed on the treatment area prior to initiating thermal cycling.
In other embodiments, the handpiece can be manually or mechanically scanned along the skin surface (See Fig. 8). Thermal cycling can be performed concurrently with scanning.
Alternatively, thermal cycling can be implemented by performing at least one (preferably, several) passes on the cooling phase, followed by at least one (preferably, several) passes on the heating phase, and repeating the cycle until desired treatment effect is achieved. Referring to Fig.Ba, an exemplary scanning handpiece is shown which includes a handle 1 and an applicator 2. Referring to Fig 8b, the applicator 2 includes a mount 3, a reflector cooling fan 4, an optional pressure or acoustic generator, vibrator ormassaging implement 5, a reflector 6, a radiation source (an arc or halogen lamp for the embodiment shown) 7, a cooling plate 8, an optional wheel 9 functioning as a mechanical velocity sensor, a cooling agent 10 and an optical filter 11.
The apparatus of Fig. 8 can be used, in particular, in a mufti-scan mode. The multi-scan mode results in non-uniform cycling of temperature at different depths.
Figure 9 shows temperature at the epidermis/dermis junction (0.1 mm depth), dermis/
hypodermis junction (2.5 mm depth) and subcutaneous fat (7.5 mm depth) as a function of time for mufti-scan operation.
Calculations have been done for the following conditions: wavelength 800-1800 nm (filtered spectrum of halogen lamp), power density 80 W/cm2, width of optical beam across scanning direction is 1 cm, speed of scan is 10 cm/s, length of scan is 50 cm, temperature of cold sapphire window in contact with the skin is -10°C. For scanning mode, the temperature of the contact plate can be significantly lower than the skin freezing temperature and at fast scanning speeds (about 10 cm/s), can be as low as -50°C without risk of cold injury. Figure 9 shows that the amplitude of thermal oscillations decreases with depth in skin. However, the time of stabilization of the temperature for deep targets can be long: 0.1 mm - 100 s or 10 scans, 2.5 mm - 5 min or 30 scans, 7.5 mm - 15 min or 90 scans.
Figure 10 shows temperatures at the blood vessels in first plexus ( 0.015 mm diameter , 0.1 mm depth), second plexus ( 0.2 mm diameter, 2.5 mm depth), and subcutaneous fat ( 0.1 mm diameter, 7.5 mm depth) as a function of time for multi-scan operation.
Calculations have been done for the following conditions: wavelength 400-1800 nm (filtered spectrum of halogen lamp), power density 65 W/cm2, width of optical beam across scanning direction is 1 cm, speed of scan is 10 cm/s, length of scan is 50 cm, temperature of cold sapphire window in contact with the skin is -10°C. Figure 10 shows that the amplitude of thermal oscillations in blood vessels is significant in the skin and negligible in the subcutaneous fat. Large temperature oscillations at the vessels in the second plexus ( up to 10 °C) can be effective for treatment of various conditions at the deep dermis and dermis/hypodennis junction and for improvement of cosmetic appearance of cellulite. Since the temperature of vessels in the subcutaneous fat is continuously rising, this treatment can be effective for increasing the rate of lypolysis.
Where energy source is a continuous wave (CW) or other long duration source, the apparatus or device for various of the embodiments may be slid or scanned over the surface of the patient's skin to overlie successive treatment regions, the dwell time, and thus the treatment duration, for each such region being a function of the rate at which the device is moved. The device may be moved over each treatment region multiple times during a single treatment.
Since the device will typically also include a skin cooling mechanism, concurrent heating and cooling is effected for each region as the device passes thereover. The device may also include a cooling mechanism ahead of the portion of the device under the energy source to pre-cool skin above the treatment region (see for example issued U.S. Patents Nos.
6,273,884 and 6,511,475, which are incorporated herein by reference). The power density PS
for this sliding mode of operation is:
PS= Po T v/d, Were 'Po is power density for the organ/region being treated in a stationary mode V is speed of sliding, d is spot or aperture size in the direction of scanning, T is interval between two consecutive passes through same spot.
Treatment time is TS = To T v/d, where To is the stationary mode treatment time for the organ/region being treated In order for the multiple passes to be beneficial, T should be less than the thermal relaxation time of the tissue being treated in the region at depth. However, when in either stationary mode or sliding mode, the treatment time can be greater than the thermal relaxation time of the tissue being treated.
Any of the embodiments can include a contact sensor to assure good optical and thermal coupling, and systems operating in the sliding mode may also include one or more motion sensors to control radiation delivery, cooling and other functions dependent on scanning speed, to enhance system safety and for other reasons.
In addition to coupling the deep heating treatment of this invention with deep cooling to enhance treatment of fat, bone, muscle, etc., the applicator may also include a massager, vibrator or other mechanical stimulation device, an ultrasonic or other acoustic stimulator or a DC or other suitable electrical stimulation source. It has been found that such mechanical or electrical stimulation is more effective when tissue temperature deviates from normal body temperature (ie., for hot or cold tissue). Similarly, the effect of deep heating may be enhanced by massage or other stimulation because both heat and cold generally penetrates better in compressed skin and subdermal tissue. Thus, the combination of deep heating and mechanical or electrical stimulation may provide significantly better results then either one alone. Heating may also be enhanced by supplementing the optical heating with, for example electro-stimulation by AC/DC, or additional heating by RF, etc. Tensioning or pressure applied to the skin overlying the treatment region may also enhance treatment effect and decrease patient discomfort/pain sensation.
While an optical radiation source has been utilized for preferred embodiments, other forms of electromagnetic radiation such as microwave or radio frequency radiation can be used on the heating phase of the cycle. Alternatively, acoustic energy can be used. Unless otherwise indicated, the term radiation, as used herein, shall refer to the output from all such sources. The power of the source utilized should be selected in order to maintain the temperature of the targeted tissue within the preferred range.
The effectiveness of the invention may also be further increased by practicing a thennotolerance regimen. In this mode, the magnitude of temperature deviations from normal skin surface temperature which a patient can tolerate increases gradually from cycle to cycle, permitting treatment temperatures, and thus treatment effectiveness to also be gradually increased from cycle to cycle. This mode allows further increasing protection of cutaneous tissues from unwanted damage.
It may also be possible to correlate the period and phase of the thermal cycle with sub-circadian biological rhythms of the patient. Such combination can further optimize treatment results by using naturally occurring oscillations of biochemical activity in cutaneous and subcutaneous tissues. Furthermore, the temporal structure of the thermal cycling can deviate from simple harmonic oscillations and be comprised, for example, of several, or even an infinite number of harmonics.
In certain embodiments, the cooling implement can be realized as a layer (film, wrap) placed over the treatment region and the irradiating applicator can be realized as a head scanned on top of the cooling implement. Thermal cycling is achieved as a result of multiple passes of the irradiating applicator.
Some embodiments of the invention can incorporate a feedback loop between the applicator and the control unit. The feedback loop can incorporate a single or multiple sensors registering the state of the apparatus and the treatment area. For example, a thermal sensor can be used to initiate the heating phase of the cycle when tissue temperature drops below a certain threshold, and initiate the cooling phase of the cycle when the temperature exceeds another threshold. Other sensor types include, but are not limited to, scanning speed sensors, contact sensors, pressure sensors, skin detectors, and skin response sensors.
In some embodiments of the invention, an additional stimulating implement can be integrated into the applicator (see Fig. 8b). The purpose of the implement is to optimize tissue structure and facilitate thermal cycling. The implement can be, for example, mechanical (lcnitting, rolling, or pulling action) or vacuum (negative/positive pressure in the treatment area). Other forms of tissue stimulation may also be utilized, for example, ultrasonic or other acoustic stimulation, or electrical stimulation.
While several embodiments of the invention have been described and illustrated herein, those of ordinary skill in the art will readily envision a variety of other means and structures for performing the functions and/or obtaining the results and/or advantages described herein, and each of such variations or modifications is deemed to be within the scope of the present invention. More generally, those skilled in the art would readily appreciate that all parameters, dimensions, materials, and configurations described herein are meant to be exemplary and that actual parameters, dimensions, materials, and configurations will depend upon specific applications for which the teachings of the present invention are used. Those skilled in the art will recognize, or be able to ascertain using no more than routine experimentation, many equivalents to the specific embodiments of the invention described herein. It is, therefore, to be understood that the foregoing embodiments are presented by way of example only and that, within the scope of the appended claims and equivalents thereto, the invention may be practiced otherwise than as specifically described. The present invention is directed to each individual feature, system, material and/or method described herein. In addition, any combination of two or more such features, systems, materials and/or methods, if such features, systems, materials and/or methods are not mutually inconsistent, is included within the scope of the present invention. In the claims, all transitional phrases or phrases of inclusion, such as "comprising," "including," "carrying," "having," "containing," and the like are to be understood to be open-ended, i.e. to mean "including but not limited to." Only the transitional phrases or phrases of inclusion "consisting of and "consisting essentially of are to be interpreted as closed or semi-closed phrases, respectively.
What is claimed is:
Claims (48)
1. A method for treating at least a selected target region at depth of a patient's body while protecting non-targeted tissue comprising:
(a) cooling the patient's skin surface to a temperature below normal body temperature for a selected duration;
(b) selectively applying radiation to the patient's skin above said region at least one of before, during and after step (a); and (c) repeating at least one of steps (a) and (b) for a selected number of cycles, the temperature to which the patient's skin surface is cooled and said duration being sufficient to cool said region to a selected temperature below normal body temperature during at least cooling portions of cycles.
(a) cooling the patient's skin surface to a temperature below normal body temperature for a selected duration;
(b) selectively applying radiation to the patient's skin above said region at least one of before, during and after step (a); and (c) repeating at least one of steps (a) and (b) for a selected number of cycles, the temperature to which the patient's skin surface is cooled and said duration being sufficient to cool said region to a selected temperature below normal body temperature during at least cooling portions of cycles.
2. A method as claimed in claim 1 wherein said selected duration is at least about seconds.
3. A method as claimed in claim 2 wherein said selected duration is between approximately 10 seconds and 30 minutes.
4. A method as claimed in claim 1 wherein step (b) is performed after step (a) and has a duration of from approximately 1 second to 4 minutes.
5. A method as claimed in claim 1 wherein step (a) is performed continuously and step (b) is performed at intervals during step (a).
6. A method as claimed in claim 1 wherein said selected region is subcutaneous fat, and wherein said selected temperature is low enough to result in at least a selective phase change of at least a portion of said fat.
7. A method as claimed in claim 6 wherein said radiation is of sufficient power and duration and of appropriate wavelength to heat said region to at least a temperature where the phase of the fat cells is altered.
8. A method as claimed in claim 1 and wherein said radiation is of sufficient power and duration and of appropriate wavelength to heat said region to at least a temperature where at least one of the biophysical and biochemical characteristics of cells in the selected region is altered.
9. A method as claimed in claim 1 wherein said radiation is of sufficient power and duration and of appropriate wavelength to heat tissue above said selected region to protect said tissue, but not to significantly heat said region.
10. A method as claimed in claim 1 wherein said treatment involves cycling cooling and heating of said region, step (b) being performed after step (a), and said radiation being of sufficient power and duration and of appropriate wavelength to heat said region to an appropriate temperature to effect said treatment.
11. A method as claimed in claim 1 including detecting a selected condition of the patient during at least one of steps (a) and (b), and utilizing said detecting step to control at least one of steps (a) and (b).
12. A method as claimed in claim 1 including stimulating said selected region during at least one of before, during and after at least one of steps (a) and (b).
13. A method as claimed in claim 12 wherein said stimulating is performed at least one of mechanically, acoustically and electrically.
14. A method as claimed in claim 1 wherein at least one of the period and phase of cycles of steps (a) and (b) are correlated with a sub-circadian biological rhythem of the patient.
15. A method as claimed in claim 1 wherein said radiation is from a continuous wave (CW) source and cooling is also performed from a substantially continuously operating source, and wherein step (a) is performed by passing an applicator outputting said cooling source over the patient's skin overlying said selected region at a selected rate, and step (b) is performed by passing an applicator outputting said radiation over the patient's skin overlying said selected region at a selected rate.
16. A method as claimed in claim 15 wherein the same applicator is used to perform both steps (a) and (b).
17. A method as claimed in claim 16 wherein steps (a) and (b) are performed during the same passes of the applicator over the patient's skin.
18. A method as claimed in claim 15 wherein when step (b) is performed with the applicator being passed over the patient's skin, radiation power is increased by a factor of T
v/d over the power required for a stationary applicator, where T is the interval between passes over the same region, v is the rate of movement of the applicator and d is applicator aperature size.
v/d over the power required for a stationary applicator, where T is the interval between passes over the same region, v is the rate of movement of the applicator and d is applicator aperature size.
19. A method as claimed in claim 18 wherein treatment time where the applicator is slid across the patient's skin is also increased by a factor of T v/d.
20. A method as claimed in claim 18 wherein T is less then the thermal relaxation time of tissue in said selected region.
21. Apparatus for treating at least a selected target region at depth of a patients body while protecting non-targeted tissue comprising:
a mechanism cooling the patient's skin surface to a temperature below normal body temperature for a selected duration;
a mechanism selectively applying radiation to the patient's skin above said region at least one of before, during and after the cooling of the patient's skin surface;
and controls causing at least one of the mechanism for cooling and the mechanism for applying radiation to be operated for a selected number of cycles, the temperature to which the patient's skin surface is cooled and said duration being sufficient to cool said region to a selected temperature below normal body temperature during at least cooling portions of cycles.
a mechanism cooling the patient's skin surface to a temperature below normal body temperature for a selected duration;
a mechanism selectively applying radiation to the patient's skin above said region at least one of before, during and after the cooling of the patient's skin surface;
and controls causing at least one of the mechanism for cooling and the mechanism for applying radiation to be operated for a selected number of cycles, the temperature to which the patient's skin surface is cooled and said duration being sufficient to cool said region to a selected temperature below normal body temperature during at least cooling portions of cycles.
22. Apparatus as claimed in claim 21 wherein said selected duration is at least about 10 seconds.
23. Apparatus as claimed in claim 22 wherein said selected duration is between approximately 10 seconds and 30 minutes.
24. Apparatus as claimed in claim 21 wherein said mechanism for applying radiation is operated after said mechanism for cooling and has a duration of from approximately 1 second to 4 minutes.
25. Apparatus as claimed in claim 21 wherein said mechanism for cooling is operated continuously and said mechanism for applying radiation is operated at intervals during the operation of the mechanism for cooling.
26. Apparatus as claimed in claim 21 wherein said selected region is subcutaneous fat, and wherein said selected temperature is low enough to result in at least a selective phase change of at least a portion of said fat.
27. Apparatus as claimed in claim 26 wherein said radiation is of sufficient power and duration and of appropriate wavelength to heat said region to at least a temperature where the phase of the fat cells is altered.
28. Apparatus as claimed in claim 21 wherein said radiation is of sufficient power and duration and of appropriate wavelength to heat said region to at least a temperature where at least one of the biophysical and biochemical characteristics of cells in said selected region is altered.
29. Apparatus as claimed in claim 21 wherein said radiation is of sufficient power and duration and of appropriate wavelength to heat tissue above said selected region to protect said tissue, but not to significantly heat said region.
30. Apparatus as claimed in claim 21 wherein said treatment involves cycling cooling and heating of said region, said mechanism for applying radiation being operated after said mechanism for cooling, and said radiation being of sufficient power and duration and of appropriate wavelength to heat said region to an appropriate temperature to effect said treatment.
31. Apparatus as claimed in claim 21 including a mechanism for detecting a selected condition of the patient during operation of at least one of said mechanisms, said controls utilizing the output from said mechanism for detecting to control at least one of the mechanism for cooling and the mechanism for applying radiation.
32. Apparatus as claimed in claim 21 including a stimulator stimulating said selected region during at least one of before, during and after operation of at least one of said mechanisms.
33. Apparatus as claimed in claim 32 wherein said stimulator is at least one of a mechanical, acoustical and electrical stimulator.
34. Apparatus as claimed in claim 21 wherein said mechanism for applying radiation includes a continuous wave (CW) source and said mechanism for cooling also operates substantially continuously, an applicator outputting said CW source passing over the patient's skin overlying said selected region at a selected rate, and an applicator for said cooling mechanism passing over the patient's skin overlying said selected region at a selected rate.
35. Apparatus as claimed in claim 34 wherein the same applicator is used for both said cooling and said radiation applying mechanisms.
36. Apparatus as claimed in claim 35 wherein said cooling and said radiation applying mechanisms are operated during the same passes of the applicator over the patient's skin.
37. Apparatus as claimed in claim 34 wherein when the radiation applying mechanism is operated with the applicator being passed over the patient's skin, radiation power is increased by a factor of T v/d over the power required for a stationary applicator, where T is the interval between passes over the same region, v is the rate of movement of the applicator and d is applicator aperature size.
38. Apparatus as claimed in claim 37 wherein treatment time where the applicator is slid across the patient's skin is also increased by a factor of T v/d.
39. Apparatus as claimed in claim 37 wherein T is less then the thermal relaxation time of tissue in said selected region.
40. A method for treating at least a selected region at depth of a patient's body while protecting tissue above the selected region, comprising:
(a) selectively delivering radiation to the patient's body above said selected region to heat said region;
(b) concurrently cooling patient tissue above said selected region to a temperature below that of the selected region; and (c) cooling said region to a temperature below that of normal body temperature at least one of before and after the heating of the region, then a being at least one cycle of heating and cooling for said region.
(a) selectively delivering radiation to the patient's body above said selected region to heat said region;
(b) concurrently cooling patient tissue above said selected region to a temperature below that of the selected region; and (c) cooling said region to a temperature below that of normal body temperature at least one of before and after the heating of the region, then a being at least one cycle of heating and cooling for said region.
41. A method as claimed in claim 40 including:(d)applying at least one of mechanical, acoustic and electrical stimulation to said region.
42. A method for treating at least a selected region at depth of a patient's body comprising:
cyclically applying radiation and cooling to the surface of the patient's skin above the selected region through at least one applicator providing substantially continuous cooling/radiation output, which applicator is passed over the patient's skin over the region multiple times for each cooling/radiation cycle.
cyclically applying radiation and cooling to the surface of the patient's skin above the selected region through at least one applicator providing substantially continuous cooling/radiation output, which applicator is passed over the patient's skin over the region multiple times for each cooling/radiation cycle.
43. A method as claimed in claim 42 wherein a single applicator simultaneously applies cooling and radiation as it is passed over the patient' skin.
44. A method as claimed in claim 42 wherein a single applicator successively applies cooling and radiation during cooling and radiation portions respectively of each cycle, the applicator making multiple passes over the patient's skin for at least one of said portions.
45. A method for treating at least a selected target region at depth of a patients body while protecting non-targeted tissue comprising:
(a) cooling the patient's skin surface to a temperature below normal body temperature for a selected duration;
(b) selectively applying radiation to the patient's skin above said region after step (a), said radiation being of sufficient power and duration and of appropriate wavelength to heat said region to an appropriate temperature to, in conjunction with step (a), effect said treatment; and (c) repeating at least one of steps (a) and (b) for a selected number of cycles, the temperature to which the patient's skin surface is cooled and said duration being sufficient to cool said region to a selected temperature below normal body temperature during at least cooling portions of cycles.
(a) cooling the patient's skin surface to a temperature below normal body temperature for a selected duration;
(b) selectively applying radiation to the patient's skin above said region after step (a), said radiation being of sufficient power and duration and of appropriate wavelength to heat said region to an appropriate temperature to, in conjunction with step (a), effect said treatment; and (c) repeating at least one of steps (a) and (b) for a selected number of cycles, the temperature to which the patient's skin surface is cooled and said duration being sufficient to cool said region to a selected temperature below normal body temperature during at least cooling portions of cycles.
46. A method for treating at least a selected target region at depth of a patients body while protecting non-targeted tissue comprising:
(a) passing an applicator outputting a substantially continuously operating cooling source over the patient's shin overlying said selected region at a selected rate to cool the patient's skin surface to a temperature below normal body temperature for a selected duration;
(b) passing an applicator outputting radiation from a substantially continuous wave radiation source over the patient's skin overlying said selected region at a selected rate to selectively applying radiation to said region at least one of before, during and after step (a); and (c) repeating at least one of steps (a) and (b) for a selected number of cycles, the temperature to which the patient's skin surface is cooled and said duration being sufficient to cool said region to a selected temperature below normal body temperature during at least cooling portions of cycles.
(a) passing an applicator outputting a substantially continuously operating cooling source over the patient's shin overlying said selected region at a selected rate to cool the patient's skin surface to a temperature below normal body temperature for a selected duration;
(b) passing an applicator outputting radiation from a substantially continuous wave radiation source over the patient's skin overlying said selected region at a selected rate to selectively applying radiation to said region at least one of before, during and after step (a); and (c) repeating at least one of steps (a) and (b) for a selected number of cycles, the temperature to which the patient's skin surface is cooled and said duration being sufficient to cool said region to a selected temperature below normal body temperature during at least cooling portions of cycles.
47. A method as claimed in claim 46 wherein the same applicator is used to perform both steps (a) and (b).
48. A method as claimed in claim 47 wherein steps (a) and (b) are performed during the same passes of the applicator over the patient's skin.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US38987102P | 2002-06-19 | 2002-06-19 | |
US60/389,871 | 2002-06-19 | ||
PCT/US2003/019280 WO2004000098A2 (en) | 2002-06-19 | 2003-06-19 | Method and apparatus for treatment of cutaneous and subcutaneous conditions |
Publications (1)
Publication Number | Publication Date |
---|---|
CA2489506A1 true CA2489506A1 (en) | 2003-12-31 |
Family
ID=30000478
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CA002489506A Abandoned CA2489506A1 (en) | 2002-06-19 | 2003-06-19 | Method and apparatus for treatment of cutaneous and subcutaneous conditions |
Country Status (10)
Country | Link |
---|---|
US (6) | US7276058B2 (en) |
EP (1) | EP1539013A4 (en) |
JP (1) | JP2005535370A (en) |
KR (1) | KR20050026404A (en) |
CN (1) | CN1329008C (en) |
AU (1) | AU2003245573A1 (en) |
BR (1) | BR0312430A (en) |
CA (1) | CA2489506A1 (en) |
IL (1) | IL165724A0 (en) |
WO (1) | WO2004000098A2 (en) |
Families Citing this family (253)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20060149343A1 (en) * | 1996-12-02 | 2006-07-06 | Palomar Medical Technologies, Inc. | Cooling system for a photocosmetic device |
US6517532B1 (en) | 1997-05-15 | 2003-02-11 | Palomar Medical Technologies, Inc. | Light energy delivery head |
US6273884B1 (en) | 1997-05-15 | 2001-08-14 | Palomar Medical Technologies, Inc. | Method and apparatus for dermatology treatment |
US8182473B2 (en) | 1999-01-08 | 2012-05-22 | Palomar Medical Technologies | Cooling system for a photocosmetic device |
US6104959A (en) | 1997-07-31 | 2000-08-15 | Microwave Medical Corp. | Method and apparatus for treating subcutaneous histological features |
US6050943A (en) | 1997-10-14 | 2000-04-18 | Guided Therapy Systems, Inc. | Imaging, therapy, and temperature monitoring ultrasonic system |
EP1566149A1 (en) | 1998-03-12 | 2005-08-24 | Palomar Medical Technologies, Inc. | System for electromagnetic radiation of the skin |
US7914453B2 (en) | 2000-12-28 | 2011-03-29 | Ardent Sound, Inc. | Visual imaging system for ultrasonic probe |
JP2005502385A (en) * | 2000-12-28 | 2005-01-27 | パロマー・メディカル・テクノロジーズ・インコーポレーテッド | Method and apparatus for performing skin therapy EMR treatment |
US6648904B2 (en) * | 2001-11-29 | 2003-11-18 | Palomar Medical Technologies, Inc. | Method and apparatus for controlling the temperature of a surface |
AU2002367397A1 (en) * | 2001-12-27 | 2003-07-24 | Palomar Medical Technologies, Inc. | Method and apparatus for improved vascular related treatment |
ES2621521T3 (en) | 2002-03-15 | 2017-07-04 | The General Hospital Corporation | Method for selective breakage of fatty tissue by controlled cooling |
US8840608B2 (en) | 2002-03-15 | 2014-09-23 | The General Hospital Corporation | Methods and devices for selective disruption of fatty tissue by controlled cooling |
US7135033B2 (en) | 2002-05-23 | 2006-11-14 | Palomar Medical Technologies, Inc. | Phototreatment device for use with coolants and topical substances |
JP2006500972A (en) * | 2002-06-19 | 2006-01-12 | パロマー・メディカル・テクノロジーズ・インコーポレイテッド | Method and apparatus for treating tissue at a depth by radiant heat |
BR0312430A (en) | 2002-06-19 | 2005-04-26 | Palomar Medical Tech Inc | Method and apparatus for treating skin and subcutaneous conditions |
US20070219605A1 (en) * | 2006-03-20 | 2007-09-20 | Palomar Medical Technologies, Inc. | Treatment of tissue volume with radiant energy |
WO2004033040A1 (en) * | 2002-10-07 | 2004-04-22 | Palomar Medical Technologies, Inc. | Apparatus for performing photobiostimulation |
US20070213792A1 (en) * | 2002-10-07 | 2007-09-13 | Palomar Medical Technologies, Inc. | Treatment Of Tissue Volume With Radiant Energy |
AU2003301111A1 (en) * | 2002-12-20 | 2004-07-22 | Palomar Medical Technologies, Inc. | Apparatus for light treatment of acne and other disorders of follicles |
US20040176754A1 (en) * | 2003-03-06 | 2004-09-09 | Island Tobin C. | Method and device for sensing skin contact |
US8709003B2 (en) * | 2003-02-25 | 2014-04-29 | Tria Beauty, Inc. | Capacitive sensing method and device for detecting skin |
WO2004077020A2 (en) * | 2003-02-25 | 2004-09-10 | Spectragenics, Inc. | Skin sensing method and apparatus |
EP2604216B1 (en) * | 2003-02-25 | 2018-08-22 | Tria Beauty, Inc. | Self-contained, diode-laser-based dermatologic treatment apparatus |
JP4361081B2 (en) * | 2003-02-25 | 2009-11-11 | トリア ビューティ インコーポレイテッド | Eye-safe dermatological treatment device |
US20040176823A1 (en) * | 2003-02-25 | 2004-09-09 | Island Tobin C. | Acne treatment device and method |
ES2570985T3 (en) * | 2003-02-25 | 2016-05-23 | Tria Beauty Inc | Apparatus and procedure for inhibiting new hair growth, safe for the eye and autonomous |
US7981111B2 (en) | 2003-02-25 | 2011-07-19 | Tria Beauty, Inc. | Method and apparatus for the treatment of benign pigmented lesions |
WO2004075721A2 (en) * | 2003-02-25 | 2004-09-10 | Spectragenics, Inc. | Self-contained, diode-laser-based dermatologic treatment apparatus and metod |
US7220254B2 (en) * | 2003-12-31 | 2007-05-22 | Palomar Medical Technologies, Inc. | Dermatological treatment with visualization |
US8777935B2 (en) | 2004-02-25 | 2014-07-15 | Tria Beauty, Inc. | Optical sensor and method for identifying the presence of skin |
JP5065005B2 (en) | 2004-04-01 | 2012-10-31 | ザ ジェネラル ホスピタル コーポレイション | Method and apparatus for dermatological treatment and tissue remodeling |
US20080132886A1 (en) * | 2004-04-09 | 2008-06-05 | Palomar Medical Technologies, Inc. | Use of fractional emr technology on incisions and internal tissues |
WO2005099369A2 (en) * | 2004-04-09 | 2005-10-27 | Palomar Medical Technologies, Inc. | Emr treated islets |
US8235909B2 (en) | 2004-05-12 | 2012-08-07 | Guided Therapy Systems, L.L.C. | Method and system for controlled scanning, imaging and/or therapy |
US7824348B2 (en) | 2004-09-16 | 2010-11-02 | Guided Therapy Systems, L.L.C. | System and method for variable depth ultrasound treatment |
US7393325B2 (en) | 2004-09-16 | 2008-07-01 | Guided Therapy Systems, L.L.C. | Method and system for ultrasound treatment with a multi-directional transducer |
US9011336B2 (en) | 2004-09-16 | 2015-04-21 | Guided Therapy Systems, Llc | Method and system for combined energy therapy profile |
US20130046209A1 (en) | 2011-07-10 | 2013-02-21 | Guided Therapy Systems, Llc | Systems and methods for improving an outside appearance of skin using ultrasound as an energy source |
US8444562B2 (en) | 2004-10-06 | 2013-05-21 | Guided Therapy Systems, Llc | System and method for treating muscle, tendon, ligament and cartilage tissue |
US8535228B2 (en) | 2004-10-06 | 2013-09-17 | Guided Therapy Systems, Llc | Method and system for noninvasive face lifts and deep tissue tightening |
US10864385B2 (en) | 2004-09-24 | 2020-12-15 | Guided Therapy Systems, Llc | Rejuvenating skin by heating tissue for cosmetic treatment of the face and body |
US11235179B2 (en) | 2004-10-06 | 2022-02-01 | Guided Therapy Systems, Llc | Energy based skin gland treatment |
US11883688B2 (en) | 2004-10-06 | 2024-01-30 | Guided Therapy Systems, Llc | Energy based fat reduction |
EP2409730A1 (en) | 2004-10-06 | 2012-01-25 | Guided Therapy Systems, L.L.C. | Method and system for ultrasound tissue treatment |
US9694212B2 (en) | 2004-10-06 | 2017-07-04 | Guided Therapy Systems, Llc | Method and system for ultrasound treatment of skin |
US7758524B2 (en) | 2004-10-06 | 2010-07-20 | Guided Therapy Systems, L.L.C. | Method and system for ultra-high frequency ultrasound treatment |
US8133180B2 (en) * | 2004-10-06 | 2012-03-13 | Guided Therapy Systems, L.L.C. | Method and system for treating cellulite |
US8690778B2 (en) | 2004-10-06 | 2014-04-08 | Guided Therapy Systems, Llc | Energy-based tissue tightening |
US9827449B2 (en) | 2004-10-06 | 2017-11-28 | Guided Therapy Systems, L.L.C. | Systems for treating skin laxity |
KR101328103B1 (en) | 2004-10-06 | 2013-11-13 | 가이디드 테라피 시스템스, 엘.엘.씨. | Method and system for noninvasive cosmetic enhancement |
US20060111744A1 (en) | 2004-10-13 | 2006-05-25 | Guided Therapy Systems, L.L.C. | Method and system for treatment of sweat glands |
US11724133B2 (en) | 2004-10-07 | 2023-08-15 | Guided Therapy Systems, Llc | Ultrasound probe for treatment of skin |
US11207548B2 (en) | 2004-10-07 | 2021-12-28 | Guided Therapy Systems, L.L.C. | Ultrasound probe for treating skin laxity |
US7780656B2 (en) * | 2004-12-10 | 2010-08-24 | Reliant Technologies, Inc. | Patterned thermal treatment using patterned cryogen spray and irradiation by light |
US8277495B2 (en) * | 2005-01-13 | 2012-10-02 | Candela Corporation | Method and apparatus for treating a diseased nail |
US8244369B2 (en) * | 2005-01-28 | 2012-08-14 | Syneron Medical Ltd. | Device and method for treating skin with temperature control |
CN101115438B (en) * | 2005-02-07 | 2010-06-16 | 皇家飞利浦电子股份有限公司 | Device for determining a stress level of a person and providing feedback on the basis of the stress level as determined |
US7856985B2 (en) | 2005-04-22 | 2010-12-28 | Cynosure, Inc. | Method of treatment body tissue using a non-uniform laser beam |
JP4695188B2 (en) | 2005-04-25 | 2011-06-08 | アーデント サウンド, インコーポレイテッド | Method and apparatus for improving the safety of computer peripherals |
US7217265B2 (en) * | 2005-05-18 | 2007-05-15 | Cooltouch Incorporated | Treatment of cellulite with mid-infrared radiation |
US7713266B2 (en) | 2005-05-20 | 2010-05-11 | Myoscience, Inc. | Subdermal cryogenic remodeling of muscles, nerves, connective tissue, and/or adipose tissue (fat) |
US20070176262A1 (en) * | 2005-08-11 | 2007-08-02 | Ernest Sirkin | Series connection of a diode laser bar |
US20070173799A1 (en) * | 2005-09-01 | 2007-07-26 | Hsia James C | Treatment of fatty tissue adjacent an eye |
JP2009509140A (en) | 2005-09-15 | 2009-03-05 | パロマー・メデイカル・テクノロジーズ・インコーポレーテツド | Skin optical determination device |
EP2796168B1 (en) * | 2005-09-28 | 2017-09-06 | Candela Corporation | Treating cellulite |
US20070078502A1 (en) * | 2005-10-05 | 2007-04-05 | Thermage, Inc. | Method and apparatus for estimating a local impedance factor |
US20070083190A1 (en) * | 2005-10-11 | 2007-04-12 | Yacov Domankevitz | Compression device for a laser handpiece |
US7957815B2 (en) * | 2005-10-11 | 2011-06-07 | Thermage, Inc. | Electrode assembly and handpiece with adjustable system impedance, and methods of operating an energy-based medical system to treat tissue |
JPWO2007046346A1 (en) * | 2005-10-18 | 2009-04-23 | テルモ株式会社 | Light irradiation device |
US8702691B2 (en) * | 2005-10-19 | 2014-04-22 | Thermage, Inc. | Treatment apparatus and methods for delivering energy at multiple selectable depths in tissue |
US7891362B2 (en) * | 2005-12-23 | 2011-02-22 | Candela Corporation | Methods for treating pigmentary and vascular abnormalities in a dermal region |
WO2007093941A1 (en) * | 2006-02-17 | 2007-08-23 | Koninklijke Philips Electronics N.V. | Orthosis and treatment method |
US7854754B2 (en) | 2006-02-22 | 2010-12-21 | Zeltiq Aesthetics, Inc. | Cooling device for removing heat from subcutaneous lipid-rich cells |
EP1837050A1 (en) * | 2006-03-24 | 2007-09-26 | WaveLight AG | Device for the irradiation of the skin |
US20070239144A1 (en) * | 2006-04-06 | 2007-10-11 | Lite Touch Ltd. | Methods of photothermolysis |
AU2007244765A1 (en) * | 2006-04-28 | 2007-11-08 | Zeltiq Aesthetics, Inc. | Cryoprotectant for use with a treatment device for improved cooling of subcutaneous lipid-rich cells |
US20070282318A1 (en) * | 2006-05-16 | 2007-12-06 | Spooner Gregory J | Subcutaneous thermolipolysis using radiofrequency energy |
US20070270925A1 (en) * | 2006-05-17 | 2007-11-22 | Juniper Medical, Inc. | Method and apparatus for non-invasively removing heat from subcutaneous lipid-rich cells including a coolant having a phase transition temperature |
US20070268955A1 (en) * | 2006-05-17 | 2007-11-22 | Pohl Hermann K | Thermal fluid device with remote temperature indicator |
US7586957B2 (en) | 2006-08-02 | 2009-09-08 | Cynosure, Inc | Picosecond laser apparatus and methods for its operation and use |
US9566454B2 (en) | 2006-09-18 | 2017-02-14 | Guided Therapy Systems, Llc | Method and sysem for non-ablative acne treatment and prevention |
US8192474B2 (en) * | 2006-09-26 | 2012-06-05 | Zeltiq Aesthetics, Inc. | Tissue treatment methods |
US9132031B2 (en) | 2006-09-26 | 2015-09-15 | Zeltiq Aesthetics, Inc. | Cooling device having a plurality of controllable cooling elements to provide a predetermined cooling profile |
US20080077201A1 (en) * | 2006-09-26 | 2008-03-27 | Juniper Medical, Inc. | Cooling devices with flexible sensors |
US9241683B2 (en) | 2006-10-04 | 2016-01-26 | Ardent Sound Inc. | Ultrasound system and method for imaging and/or measuring displacement of moving tissue and fluid |
US8641660B2 (en) * | 2006-10-04 | 2014-02-04 | P Tech, Llc | Methods and devices for controlling biologic microenvironments |
US9101524B2 (en) * | 2006-11-09 | 2015-08-11 | Lumenis Ltd. | Apparatus and method for treating tissue |
WO2008074005A1 (en) * | 2006-12-13 | 2008-06-19 | Palomar Medical Technologies, Inc. | Cosmetic and biomedical applications of ultrasonic energy and methods of generation thereof |
US20080172105A1 (en) * | 2007-01-17 | 2008-07-17 | Ws Far Ir Medical Technology Co., Ltd. | Method for preventing and/or ameliorating inflammation |
WO2008091983A2 (en) * | 2007-01-25 | 2008-07-31 | Thermage, Inc. | Treatment apparatus and methods for inducing microburn patterns in tissue |
US20080188914A1 (en) * | 2007-02-01 | 2008-08-07 | Candela Corporation | Detachable handpiece |
US20080221649A1 (en) * | 2007-03-09 | 2008-09-11 | Agustina Echague | Method of sequentially treating tissue |
WO2008131306A1 (en) | 2007-04-19 | 2008-10-30 | The Foundry, Inc. | Systems and methods for creating an effect using microwave energy to specified tissue |
RU2523620C2 (en) | 2007-04-19 | 2014-07-20 | Мирамар Лэбс,Инк. | Systems and methods for generating exposure on target tissue with using microwave energy |
US9241763B2 (en) | 2007-04-19 | 2016-01-26 | Miramar Labs, Inc. | Systems, apparatus, methods and procedures for the noninvasive treatment of tissue using microwave energy |
EP2142129A4 (en) | 2007-04-19 | 2011-04-20 | Miramar Labs Inc | Methods and apparatus for reducing sweat production |
EP2142125B1 (en) | 2007-04-19 | 2014-03-05 | Miramar Labs, Inc. | Devices, and systems for non-invasive delivery of microwave therapy |
US20150174388A1 (en) | 2007-05-07 | 2015-06-25 | Guided Therapy Systems, Llc | Methods and Systems for Ultrasound Assisted Delivery of a Medicant to Tissue |
JP2010526589A (en) | 2007-05-07 | 2010-08-05 | ガイデッド セラピー システムズ, エル.エル.シー. | Method and system for modulating a mediant using acoustic energy |
DK2152167T3 (en) | 2007-05-07 | 2018-12-10 | Guided Therapy Systems Llc | Methods and systems for coupling and focusing acoustic energy using a coupling element |
AU2012244313B2 (en) * | 2007-05-18 | 2014-11-27 | Zeltiq Aesthetics, Inc. | Device for enhanced removal of heat from subcutaneous lipid-rich cells having an actuator |
US20080287839A1 (en) | 2007-05-18 | 2008-11-20 | Juniper Medical, Inc. | Method of enhanced removal of heat from subcutaneous lipid-rich cells and treatment apparatus having an actuator |
EP2155098A4 (en) * | 2007-06-08 | 2013-11-06 | Cynosure Inc | Thermal surgery safety apparatus and method |
US20090018522A1 (en) * | 2007-07-10 | 2009-01-15 | Anima Ventures Ltd. | Tissue modification by targeted delivery of heat |
WO2009009661A1 (en) * | 2007-07-10 | 2009-01-15 | Thermage, Inc. | Treatment apparatus and methods for delivering high frequency energy across large tissue areas |
US20090018624A1 (en) * | 2007-07-13 | 2009-01-15 | Juniper Medical, Inc. | Limiting use of disposable system patient protection devices |
US20090018625A1 (en) * | 2007-07-13 | 2009-01-15 | Juniper Medical, Inc. | Managing system temperature to remove heat from lipid-rich regions |
US8523927B2 (en) * | 2007-07-13 | 2013-09-03 | Zeltiq Aesthetics, Inc. | System for treating lipid-rich regions |
US20090018626A1 (en) * | 2007-07-13 | 2009-01-15 | Juniper Medical, Inc. | User interfaces for a system that removes heat from lipid-rich regions |
ES2693430T3 (en) | 2007-08-21 | 2018-12-11 | Zeltiq Aesthetics, Inc. | Monitoring of cooling of lipid-rich subcutaneous cells, such as cooling of adipose tissue |
US20090149796A1 (en) * | 2007-12-06 | 2009-06-11 | Jones Dennis R | Use of Iontophoresis and Ultrasound to Deliver Melanin or Other Chromophores for Laser Hair Removal |
ES2471971T3 (en) | 2007-12-12 | 2014-06-27 | Miramar Labs, Inc. | System and apparatus for non-invasive treatment of tissue using microwave energy |
AU2008335715B2 (en) | 2007-12-12 | 2014-01-23 | Miradry, Inc. | Systems, apparatus, methods and procedures for the noninvasive treatment of tissue using microwave energy |
US20090254005A1 (en) * | 2008-04-03 | 2009-10-08 | Eilaz Babaev | Ultrasound assisted tissue welding device |
ITMI20080628A1 (en) * | 2008-04-09 | 2009-10-10 | Novavision Group S R L | ULTRASONIC DEVICE PERFECTED, PARTICULARLY FOR THE TREATMENT OF ADIPOSE FABRIC. |
US9687671B2 (en) * | 2008-04-25 | 2017-06-27 | Channel Investments, Llc | Optical sensor and method for identifying the presence of skin and the pigmentation of skin |
CN104545998B (en) | 2008-06-06 | 2020-07-14 | 奥赛拉公司 | System and method for cosmetic treatment and imaging |
EP2318093B1 (en) * | 2008-07-02 | 2019-11-13 | Sage Products, LLC | Systems for automated muscle stimulation |
US8892210B2 (en) | 2008-07-02 | 2014-11-18 | Niveus Medical, Inc. | Devices, systems, and methods for automated optimization of energy delivery |
US20100036368A1 (en) * | 2008-08-11 | 2010-02-11 | Laura England | Method of selectively heating adipose tissue |
US9149386B2 (en) | 2008-08-19 | 2015-10-06 | Niveus Medical, Inc. | Devices and systems for stimulation of tissues |
US8265763B2 (en) * | 2008-08-26 | 2012-09-11 | Niveus Medical, Inc. | Device, system, and method to improve powered muscle stimulation performance in the presence of tissue edema |
WO2010036732A1 (en) * | 2008-09-25 | 2010-04-01 | Zeltiq Aesthetics, Inc. | Treatment planning systems and methods for body contouring applications |
US9532717B2 (en) * | 2008-10-28 | 2017-01-03 | The Procter & Gamble Company | Method for diagnosing vulvovaginal disorders |
US8603073B2 (en) * | 2008-12-17 | 2013-12-10 | Zeltiq Aesthetics, Inc. | Systems and methods with interrupt/resume capabilities for treating subcutaneous lipid-rich cells |
JP2012513837A (en) | 2008-12-24 | 2012-06-21 | ガイデッド セラピー システムズ, エルエルシー | Method and system for fat loss and / or cellulite treatment |
AU2010215784B2 (en) * | 2009-02-20 | 2015-04-30 | Sage Products, Llc | Systems and methods of powered muscle stimulation using an energy guidance field |
US20100234737A1 (en) * | 2009-03-12 | 2010-09-16 | Miranda Aref Farage | Method for assessing skin irritation using infrared light |
ES2407531T3 (en) * | 2009-04-22 | 2013-06-12 | Radiancy Inc. | Skin treatment device that uses light and temperature |
WO2010127315A2 (en) | 2009-04-30 | 2010-11-04 | Zeltiq Aesthetics, Inc. | Device, system and method of removing heat from subcutaneous lipid-rich cells |
US9919168B2 (en) | 2009-07-23 | 2018-03-20 | Palomar Medical Technologies, Inc. | Method for improvement of cellulite appearance |
RU2012107673A (en) | 2009-08-04 | 2013-09-10 | Поллоген Лтд. | COSMETIC REJUVENATION OF SKIN |
CA2777846C (en) | 2009-11-11 | 2021-09-14 | Niveus Medical, Inc. | Synergistic muscle activation device |
US11590346B2 (en) | 2009-11-16 | 2023-02-28 | Pollogen Ltd. | Apparatus and method for cosmetic treatment of human mucosal tissue |
CA2780607A1 (en) * | 2009-11-16 | 2011-05-19 | Pollogen Ltd. | Non-invasive fat removal |
US8715186B2 (en) | 2009-11-24 | 2014-05-06 | Guided Therapy Systems, Llc | Methods and systems for generating thermal bubbles for improved ultrasound imaging and therapy |
US20110190745A1 (en) * | 2009-12-04 | 2011-08-04 | Uebelhoer Nathan S | Treatment of sweat glands |
KR20120113788A (en) | 2010-01-25 | 2012-10-15 | 젤티크 애스세틱스, 인코포레이티드. | Home-use applicators for non-invasively removing heat from subcutaneous lipid-rich cells via phase change coolants, and associated devices, systems and methods |
US8676338B2 (en) | 2010-07-20 | 2014-03-18 | Zeltiq Aesthetics, Inc. | Combined modality treatment systems, methods and apparatus for body contouring applications |
CA2802481A1 (en) * | 2010-07-24 | 2012-02-09 | Liposonix, Inc. | Apparatus and methods for non-invasive body contouring |
EP2600937B8 (en) | 2010-08-02 | 2024-03-06 | Guided Therapy Systems, L.L.C. | Systems for treating acute and/or chronic injuries in soft tissue |
US9504446B2 (en) | 2010-08-02 | 2016-11-29 | Guided Therapy Systems, Llc | Systems and methods for coupling an ultrasound source to tissue |
WO2012020361A1 (en) | 2010-08-11 | 2012-02-16 | Koninklijke Philips Electronics N.V. | Phototherapy method and device |
US8857438B2 (en) | 2010-11-08 | 2014-10-14 | Ulthera, Inc. | Devices and methods for acoustic shielding |
US10722395B2 (en) | 2011-01-25 | 2020-07-28 | Zeltiq Aesthetics, Inc. | Devices, application systems and methods with localized heat flux zones for removing heat from subcutaneous lipid-rich cells |
US20140121733A1 (en) * | 2011-04-19 | 2014-05-01 | Hiroki Shima | Cell activation device |
WO2013012641A1 (en) | 2011-07-11 | 2013-01-24 | Guided Therapy Systems, Llc | Systems and methods for coupling an ultrasound source to tissue |
US9314301B2 (en) | 2011-08-01 | 2016-04-19 | Miramar Labs, Inc. | Applicator and tissue interface module for dermatological device |
US9700245B2 (en) | 2011-09-23 | 2017-07-11 | Itrace Biomedical Inc. | Transdermal analyte extraction and detection system and the method thereof |
US8548599B2 (en) * | 2011-11-16 | 2013-10-01 | Btl Holdings Limited | Methods and systems for subcutaneous treatments |
US9867996B2 (en) | 2011-11-16 | 2018-01-16 | Btl Holdings Limited | Methods and systems for skin treatment |
US20130123765A1 (en) * | 2011-11-16 | 2013-05-16 | Btl Holdings Limited | Methods and systems for subcutaneous treatments |
US9263663B2 (en) | 2012-04-13 | 2016-02-16 | Ardent Sound, Inc. | Method of making thick film transducer arrays |
US9780518B2 (en) | 2012-04-18 | 2017-10-03 | Cynosure, Inc. | Picosecond laser apparatus and methods for treating target tissues with same |
WO2013168051A1 (en) * | 2012-05-07 | 2013-11-14 | Koninklijke Philips N.V. | Radio -frequency system for skin treatment including a roller with an electrode and a method for skin treatment |
US9522289B2 (en) | 2012-05-08 | 2016-12-20 | The Regents Of The University Of California | Selective fat removal using photothermal heating |
CA2877125C (en) * | 2012-06-25 | 2022-08-02 | Niveus Medical, Inc. | Devices and systems for stimulation of tissues |
DE102012013534B3 (en) | 2012-07-05 | 2013-09-19 | Tobias Sokolowski | Apparatus for repetitive nerve stimulation for the degradation of adipose tissue by means of inductive magnetic fields |
WO2014040015A1 (en) | 2012-09-10 | 2014-03-13 | Dermal Photonics Corporation | Systems and methods for treating dermatological imperfections |
US9510802B2 (en) | 2012-09-21 | 2016-12-06 | Guided Therapy Systems, Llc | Reflective ultrasound technology for dermatological treatments |
US10179239B2 (en) | 2013-01-15 | 2019-01-15 | Itrace Biomedical Inc. | Personalized pain management treatments |
US9710607B2 (en) | 2013-01-15 | 2017-07-18 | Itrace Biomedical Inc. | Portable electronic therapy device and the method thereof |
RU2514107C1 (en) * | 2013-03-06 | 2014-04-27 | Федеральное государственное унитарное предприятие "Государственный научный центр "Научно-исследовательский институт органических полупродуктов и красителей" (ФГУП "ГНЦ "НИОПИК") | Method for photodynamic therapy of patients with metastatic tumoural pleuritis |
CN204017181U (en) | 2013-03-08 | 2014-12-17 | 奥赛拉公司 | Aesthstic imaging and processing system, multifocal processing system and perform the system of aesthetic procedure |
US9545523B2 (en) | 2013-03-14 | 2017-01-17 | Zeltiq Aesthetics, Inc. | Multi-modality treatment systems, methods and apparatus for altering subcutaneous lipid-rich tissue |
US10143831B2 (en) | 2013-03-14 | 2018-12-04 | Cynosure, Inc. | Electrosurgical systems and methods |
US9844460B2 (en) | 2013-03-14 | 2017-12-19 | Zeltiq Aesthetics, Inc. | Treatment systems with fluid mixing systems and fluid-cooled applicators and methods of using the same |
US10561862B2 (en) | 2013-03-15 | 2020-02-18 | Guided Therapy Systems, Llc | Ultrasound treatment device and methods of use |
US10492849B2 (en) | 2013-03-15 | 2019-12-03 | Cynosure, Llc | Surgical instruments and systems with multimodes of treatments and electrosurgical operation |
WO2014145707A2 (en) | 2013-03-15 | 2014-09-18 | Cynosure, Inc. | Picosecond optical radiation systems and methods of use |
US10779885B2 (en) | 2013-07-24 | 2020-09-22 | Miradry. Inc. | Apparatus and methods for the treatment of tissue using microwave energy |
KR102364395B1 (en) * | 2013-08-09 | 2022-02-17 | 더 제너럴 하스피탈 코포레이션 | Method and apparatus for treating dermal melasma |
USD747800S1 (en) | 2013-09-10 | 2016-01-19 | Dermal Photonics Corporation | Dermatological medical device |
US10064940B2 (en) | 2013-12-11 | 2018-09-04 | Siva Therapeutics Inc. | Multifunctional radiation delivery apparatus and method |
US20170165105A1 (en) * | 2014-01-31 | 2017-06-15 | The General Hospital Corporation | Methods, kits, and cooling devices for disrupting function of one or more sebaceous glands |
WO2015117032A1 (en) | 2014-01-31 | 2015-08-06 | Zeltiq Aesthestic, Inc. | Treatment systems for treating glands by cooling |
US10675176B1 (en) | 2014-03-19 | 2020-06-09 | Zeltiq Aesthetics, Inc. | Treatment systems, devices, and methods for cooling targeted tissue |
USD777338S1 (en) | 2014-03-20 | 2017-01-24 | Zeltiq Aesthetics, Inc. | Cryotherapy applicator for cooling tissue |
SG11201608691YA (en) | 2014-04-18 | 2016-11-29 | Ulthera Inc | Band transducer ultrasound therapy |
US10952891B1 (en) | 2014-05-13 | 2021-03-23 | Zeltiq Aesthetics, Inc. | Treatment systems with adjustable gap applicators and methods for cooling tissue |
US9820801B2 (en) * | 2014-06-03 | 2017-11-21 | Suzanne Anderer | Epilation by thermolysis |
US10935174B2 (en) | 2014-08-19 | 2021-03-02 | Zeltiq Aesthetics, Inc. | Stress relief couplings for cryotherapy apparatuses |
US10568759B2 (en) | 2014-08-19 | 2020-02-25 | Zeltiq Aesthetics, Inc. | Treatment systems, small volume applicators, and methods for treating submental tissue |
WO2016035082A1 (en) * | 2014-09-04 | 2016-03-10 | Dr. Eyal Bressler Ltd. | Assembly for photodynamic therapy |
US10758404B2 (en) | 2014-09-15 | 2020-09-01 | Divergent Med Llc | Cooling system for localized and non-invasive cooling treatment |
AU2016209190A1 (en) * | 2015-01-23 | 2017-08-10 | Marcio Marc Abreu | Apparatus and method for skin treatment |
US10039600B2 (en) * | 2015-02-03 | 2018-08-07 | L'oreal | Apparatus and method for skin treatment using pulsed light |
WO2016126806A1 (en) * | 2015-02-03 | 2016-08-11 | Ino Beauty Inc. | Anti-aging device for stimulating scalp and hair health |
US9962553B2 (en) | 2015-03-04 | 2018-05-08 | Btl Holdings Limited | Device and method for contactless skin treatment |
US10737109B2 (en) | 2015-04-23 | 2020-08-11 | Cynosure, Llc | Systems and methods of unattended treatment of a subject's head or neck |
US10518104B2 (en) | 2015-04-23 | 2019-12-31 | Cynosure, Llc | Systems and methods of unattended treatment |
US11491342B2 (en) | 2015-07-01 | 2022-11-08 | Btl Medical Solutions A.S. | Magnetic stimulation methods and devices for therapeutic treatments |
US10737112B2 (en) * | 2015-05-13 | 2020-08-11 | Sauna Works Inc. | Water-filtered near infrared sauna |
WO2016209834A1 (en) | 2015-06-22 | 2016-12-29 | Quantum Dynamics L.L.C. | Device for providing body temperature regulation and/or therapeutic light directed to vasculature |
US10709894B2 (en) | 2015-07-01 | 2020-07-14 | Btl Medical Technologies S.R.O. | Aesthetic method of biological structure treatment by magnetic field |
US20180001107A1 (en) | 2016-07-01 | 2018-01-04 | Btl Holdings Limited | Aesthetic method of biological structure treatment by magnetic field |
US10471269B1 (en) | 2015-07-01 | 2019-11-12 | Btl Medical Technologies S.R.O. | Aesthetic method of biological structure treatment by magnetic field |
US10478633B2 (en) | 2015-07-01 | 2019-11-19 | Btl Medical Technologies S.R.O. | Aesthetic method of biological structure treatment by magnetic field |
US10569095B1 (en) | 2015-07-01 | 2020-02-25 | Btl Medical Technologies S.R.O. | Aesthetic method of biological structure treatment by magnetic field |
US10569094B2 (en) | 2015-07-01 | 2020-02-25 | Btl Medical Technologies S.R.O. | Aesthetic method of biological structure treatment by magnetic field |
US11266850B2 (en) | 2015-07-01 | 2022-03-08 | Btl Healthcare Technologies A.S. | High power time varying magnetic field therapy |
US10695576B2 (en) | 2015-07-01 | 2020-06-30 | Btl Medical Technologies S.R.O. | Aesthetic method of biological structure treatment by magnetic field |
US10478634B2 (en) | 2015-07-01 | 2019-11-19 | Btl Medical Technologies S.R.O. | Aesthetic method of biological structure treatment by magnetic field |
US10821295B1 (en) | 2015-07-01 | 2020-11-03 | Btl Medical Technologies S.R.O. | Aesthetic method of biological structure treatment by magnetic field |
US10695575B1 (en) | 2016-05-10 | 2020-06-30 | Btl Medical Technologies S.R.O. | Aesthetic method of biological structure treatment by magnetic field |
US9937358B2 (en) | 2015-07-01 | 2018-04-10 | Btl Holdings Limited | Aesthetic methods of biological structure treatment by magnetic field |
BR112018001857B1 (en) | 2015-07-28 | 2022-11-08 | Know Bio, Llc | PHOTOTHERAPEUTIC DEVICE FOR DELIVERING LIGHT EMISSIONS TO A PATIENT'S SCALP |
EP3328491A4 (en) | 2015-07-28 | 2019-05-01 | PhotonMD, Inc. | Systems and methods for phototherapeutic modulation of nitric oxide |
US11484724B2 (en) * | 2015-09-30 | 2022-11-01 | Btl Medical Solutions A.S. | Methods and devices for tissue treatment using mechanical stimulation and electromagnetic field |
US10080906B2 (en) * | 2015-09-30 | 2018-09-25 | Btl Holdings Limited | Methods and devices for tissue treatment using mechanical stimulation and electromagnetic field |
US9636516B2 (en) * | 2015-09-30 | 2017-05-02 | Btl Holdings Limited | Methods and devices for tissue treatment using shock waves and electromagnetic field |
WO2017070112A1 (en) | 2015-10-19 | 2017-04-27 | Zeltiq Aesthetics, Inc. | Vascular treatment systems, cooling devices, and methods for cooling vascular structures |
US11253717B2 (en) | 2015-10-29 | 2022-02-22 | Btl Healthcare Technologies A.S. | Aesthetic method of biological structure treatment by magnetic field |
CN108472151B (en) | 2016-01-07 | 2020-10-27 | 斯尔替克美学股份有限公司 | Temperature-dependent adhesion between applicator and skin during tissue cooling |
FR3046545B1 (en) * | 2016-01-07 | 2021-05-28 | Urgo Rech Innovation Et Developpement | DERMATOLOGICAL TREATMENT DEVICE EQUIPPED WITH A FAN MONITORING MEANS |
ES2939604T3 (en) | 2016-01-18 | 2023-04-25 | Ulthera Inc | Compact ultrasonic device having an annular ultrasonic array peripherally electrically connected to a flexible printed circuit board |
US10765552B2 (en) | 2016-02-18 | 2020-09-08 | Zeltiq Aesthetics, Inc. | Cooling cup applicators with contoured heads and liner assemblies |
EP3207957A1 (en) * | 2016-02-22 | 2017-08-23 | Koninklijke Philips N.V. | Hair care device |
WO2017180663A1 (en) | 2016-04-11 | 2017-10-19 | Cynosure, Inc. | Systems and methods of unattended treatment of a subject's head or neck |
US11247039B2 (en) | 2016-05-03 | 2022-02-15 | Btl Healthcare Technologies A.S. | Device including RF source of energy and vacuum system |
US11464993B2 (en) | 2016-05-03 | 2022-10-11 | Btl Healthcare Technologies A.S. | Device including RF source of energy and vacuum system |
US10682297B2 (en) | 2016-05-10 | 2020-06-16 | Zeltiq Aesthetics, Inc. | Liposomes, emulsions, and methods for cryotherapy |
US11382790B2 (en) | 2016-05-10 | 2022-07-12 | Zeltiq Aesthetics, Inc. | Skin freezing systems for treating acne and skin conditions |
US11534619B2 (en) | 2016-05-10 | 2022-12-27 | Btl Medical Solutions A.S. | Aesthetic method of biological structure treatment by magnetic field |
US10555831B2 (en) | 2016-05-10 | 2020-02-11 | Zeltiq Aesthetics, Inc. | Hydrogel substances and methods of cryotherapy |
US10709895B2 (en) | 2016-05-10 | 2020-07-14 | Btl Medical Technologies S.R.O. | Aesthetic method of biological structure treatment by magnetic field |
US10583287B2 (en) | 2016-05-23 | 2020-03-10 | Btl Medical Technologies S.R.O. | Systems and methods for tissue treatment |
US10556122B1 (en) | 2016-07-01 | 2020-02-11 | Btl Medical Technologies S.R.O. | Aesthetic method of biological structure treatment by magnetic field |
US11241218B2 (en) | 2016-08-16 | 2022-02-08 | Ulthera, Inc. | Systems and methods for cosmetic ultrasound treatment of skin |
BR112019010363A2 (en) | 2016-11-22 | 2019-08-27 | Dominion Aesthetic Tech Inc | systems and methods for aesthetic treatment |
US10293148B2 (en) * | 2017-01-06 | 2019-05-21 | Paul Dabney | System, retainer and method of preventing and treating nosocomial infections including methicillin-resistant Staphylococcus aureus infections |
US10744337B2 (en) * | 2017-04-13 | 2020-08-18 | Multi Radiance Medical | Photobiomodulation therapy to reduce the effects of fibromyalgia |
US11076879B2 (en) | 2017-04-26 | 2021-08-03 | Zeltiq Aesthetics, Inc. | Shallow surface cryotherapy applicators and related technology |
EP3634290B1 (en) * | 2017-06-07 | 2024-01-24 | Cynosure, LLC | System for fat reduction and improving skin laxity |
US20190099616A1 (en) * | 2017-10-03 | 2019-04-04 | General Electric Company | Omniblanket for infant warming and increased efficiency phototherapy |
US11400308B2 (en) | 2017-11-21 | 2022-08-02 | Cutera, Inc. | Dermatological picosecond laser treatment systems and methods using optical parametric oscillator |
AU2019217623B2 (en) | 2018-02-07 | 2021-10-28 | Cynosure, Inc. | Methods and apparatus for controlled RF treatments and RF generator system |
US11944849B2 (en) | 2018-02-20 | 2024-04-02 | Ulthera, Inc. | Systems and methods for combined cosmetic treatment of cellulite with ultrasound |
WO2019165426A1 (en) | 2018-02-26 | 2019-08-29 | Cynosure, Inc. | Q-switched cavity dumped sub-nanosecond laser |
CA3107932A1 (en) | 2018-07-31 | 2020-02-06 | Zeltiq Aesthetics, Inc. | Methods, devices, and systems for improving skin characteristics |
US10677866B1 (en) * | 2018-11-28 | 2020-06-09 | Insightec, Ltd. | Systems and methods for correcting measurement artifacts in MR thermometry |
PL4066887T3 (en) | 2019-04-11 | 2024-03-04 | Btl Medical Solutions A.S. | Devices for aesthetic treatment of biological structures by radiofrequency and magnetic energy |
USD1005484S1 (en) | 2019-07-19 | 2023-11-21 | Cynosure, Llc | Handheld medical instrument and docking base |
US11253720B2 (en) | 2020-02-29 | 2022-02-22 | Cutera, Inc. | Dermatological systems and methods with handpiece for coaxial pulse delivery and temperature sensing |
US10864380B1 (en) | 2020-02-29 | 2020-12-15 | Cutera, Inc. | Systems and methods for controlling therapeutic laser pulse duration |
US11147984B2 (en) | 2020-03-19 | 2021-10-19 | Know Bio, Llc | Illumination devices for inducing biological effects |
GB202005820D0 (en) * | 2020-04-21 | 2020-06-03 | Michelson Diagnostics Ltd | Treatment apparatus |
KR20230000081U (en) | 2020-05-04 | 2023-01-10 | 비티엘 헬쓰케어 테크놀로지스 에이.에스. | Device and method for unattended treatment of patients |
US11878167B2 (en) | 2020-05-04 | 2024-01-23 | Btl Healthcare Technologies A.S. | Device and method for unattended treatment of a patient |
JP2023527680A (en) * | 2020-05-05 | 2023-06-30 | ルメダ インコーポレイテッド | Time multiple dosimetry system and method |
US11654294B2 (en) | 2021-03-15 | 2023-05-23 | Know Bio, Llc | Intranasal illumination devices |
US11896816B2 (en) | 2021-11-03 | 2024-02-13 | Btl Healthcare Technologies A.S. | Device and method for unattended treatment of a patient |
Family Cites Families (1249)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US853033A (en) | 1906-07-11 | 1907-05-07 | Harvey H Roberts | Portable electric-light cabinet. |
US1590283A (en) | 1924-10-20 | 1926-06-29 | De Forest B Catlin | Therapeutic device |
BE346723A (en) | 1926-11-13 | |||
US1676183A (en) | 1927-05-03 | 1928-07-03 | Jacob N Garfunkle | Attachment for razors |
US2068721A (en) * | 1932-11-18 | 1937-01-26 | Wappler Frederick Charles | Method for electrosurgical severance of adhesions |
US2472385A (en) | 1946-07-18 | 1949-06-07 | Michael A Rollman | Massage device |
US2669771A (en) * | 1949-11-17 | 1954-02-23 | Gen Motors Corp | Armature coil lead staker |
US3327712A (en) * | 1961-09-15 | 1967-06-27 | Ira H Kaufman | Photocoagulation type fiber optical surgical device |
US3261978A (en) | 1963-05-27 | 1966-07-19 | Henry S Brenman | Dental cleaning apparatus |
US3243650A (en) * | 1964-01-15 | 1966-03-29 | Ralph W Hawkins | Continuous ionization of flash lamps |
US3284665A (en) | 1964-01-29 | 1966-11-08 | Edgerton Germeshausen & Grier | Multiple electrode flashlamp circuit with a gas holdoff tube in circuit with a trigger electrode adjacent the anode |
US3651425A (en) * | 1964-12-22 | 1972-03-21 | Us Army | Multiple unit laser system |
US3524144A (en) | 1965-07-13 | 1970-08-11 | Us Army | Laser generator having a shock-induced narrow band illuminator |
US3465203A (en) | 1966-06-02 | 1969-09-02 | Xerox Corp | Flashlamp for electroscopic toner |
US3538919A (en) | 1967-04-07 | 1970-11-10 | Gregory System Inc | Depilation by means of laser energy |
US3527932A (en) * | 1967-11-16 | 1970-09-08 | James J Thomas | Transilluminating flashlight |
US3486070A (en) | 1968-04-29 | 1969-12-23 | Westinghouse Electric Corp | Solid-state constant power ballast for electric discharge device |
US3597652A (en) | 1969-01-14 | 1971-08-03 | Eg & G Inc | Apparatus for maintaining the temperature and operating a calibrated lamp in a constant resistance mode |
GB1251424A (en) | 1969-03-21 | 1971-10-27 | ||
US3622743A (en) | 1969-04-28 | 1971-11-23 | Hrand M Muncheryan | Laser eraser and microwelder |
US4456872A (en) | 1969-10-27 | 1984-06-26 | Bose Corporation | Current controlled two-state modulation |
US4038984A (en) | 1970-02-04 | 1977-08-02 | Electro Medical Systems, Inc. | Method and apparatus for high frequency electric surgery |
US3653778A (en) | 1970-04-16 | 1972-04-04 | John Robert Freiling | Applicator device for toothpaste dispensers or the like |
US3667454A (en) | 1970-06-12 | 1972-06-06 | Larry W Prince | Toothbrush with ultraviolet emitter |
US3693623A (en) * | 1970-12-25 | 1972-09-26 | Gregory System Inc | Photocoagulation means and method for depilation |
US3725733A (en) | 1971-04-19 | 1973-04-03 | Us Navy | Ultrafast multiple flashlamp |
US3699967A (en) | 1971-04-30 | 1972-10-24 | Valleylab Inc | Electrosurgical generator |
US3766488A (en) | 1971-06-17 | 1973-10-16 | Bell Telephone Labor Inc | Dye laser with pump cavity mode matched to laser resonator |
DE2145921C2 (en) | 1971-09-14 | 1982-05-06 | Günther Dr. 8022 Grünwald Nath | Device for material processing by means of a laser beam with a flexible light guide |
US3766393A (en) | 1971-11-22 | 1973-10-16 | Rca Corp | Optical data transmission system employing polarization-shift, multiple-cavity laser |
US3793723A (en) * | 1971-12-03 | 1974-02-26 | Ultrasonic Systems | Ultrasonic replaceable shaving head and razor |
US3846811A (en) | 1972-03-29 | 1974-11-05 | Canon Kk | Flash unit for use with camera |
US3769963A (en) | 1972-03-31 | 1973-11-06 | L Goldman | Instrument for performing laser micro-surgery and diagnostic transillumination of living human tissue |
US3818914A (en) * | 1972-04-17 | 1974-06-25 | Spectroderm Inc | Apparatus and method for treatment of skin disorders |
FR2199453B1 (en) | 1972-05-12 | 1974-10-25 | Busser Francis | |
US3857015A (en) | 1972-11-08 | 1974-12-24 | O Richardson | Electrically heated heat sealing implement |
US3885569A (en) | 1972-11-21 | 1975-05-27 | Birtcher Corp | Electrosurgical unit |
US3818373A (en) | 1973-01-08 | 1974-06-18 | Gen Electric | Single pockels cell double pulsing scheme |
US3834391A (en) * | 1973-01-19 | 1974-09-10 | Block Carol Ltd | Method and apparatus for photoepilation |
GB1458356A (en) * | 1973-01-31 | 1976-12-15 | Wilkinson Sword Ltd | Shaving equipment |
US3815046A (en) | 1973-02-07 | 1974-06-04 | Atomic Energy Commission | Synchronously driven q-switched or q-switched-mode-locked laser oscillator |
US3821510A (en) | 1973-02-22 | 1974-06-28 | H Muncheryan | Hand held laser instrumentation device |
US3794028A (en) * | 1973-02-27 | 1974-02-26 | A Griffin | Method for injecting chemicals into the papilla for depilation |
US3980861A (en) | 1973-03-26 | 1976-09-14 | Akio Fukunaga | Electrically heated miniature thermal implement |
US3909649A (en) | 1973-04-05 | 1975-09-30 | Gen Electric | Electric lamp with light-diffusing coating |
US3914709A (en) | 1973-05-14 | 1975-10-21 | Jersey Nuclear Avco Isotopes | Apparatus for lengthening laser output pulse duration |
US3890537A (en) | 1974-01-02 | 1975-06-17 | Gen Electric | Solid state chopper ballast for gaseous discharge lamps |
US3977083A (en) | 1974-02-05 | 1976-08-31 | Norman Leslie | Dental instrument |
US3858577A (en) * | 1974-04-05 | 1975-01-07 | Univ Southern California | Fiber optic laser light delivery system |
US3900034A (en) * | 1974-04-10 | 1975-08-19 | Us Energy | Photochemical stimulation of nerves |
GB1485908A (en) | 1974-05-21 | 1977-09-14 | Nath G | Apparatus for applying light radiation |
DE2444893B2 (en) | 1974-09-19 | 1976-07-22 | Heimann Gmbh, 6200 Wiesbaden-Dotzheim | CIRCUIT ARRANGEMENT FOR IGNITING AT LEAST ONE GAS DISCHARGE FLASHING LAMP |
CA1086172A (en) | 1975-03-14 | 1980-09-23 | Robert F. Shaw | Surgical instrument having self-regulating radiant heating of its cutting edge and method of using the same |
US4133503A (en) * | 1975-08-29 | 1979-01-09 | Bliss John H | Entry, display and use of data employed to overcome aircraft control problems due to wind shear |
US4065370A (en) | 1975-11-18 | 1977-12-27 | The United States Of America As Represented By The Secretary Of The Army | Method of ion plating a thin metallic strip for flashlamp starting |
US4019156A (en) | 1975-12-02 | 1977-04-19 | The United States Of America As Represented By The United States Energy Research And Development Administration | Active/passive mode-locked laser oscillator |
DE2609273A1 (en) | 1976-03-05 | 1977-09-08 | Mutzhas Maximilian F | IRRADIATION DEVICE WITH ULTRAVIOLET RADIATION SOURCE |
US4047106A (en) | 1976-06-01 | 1977-09-06 | Charles Elbert Robinson | Motor speed sensor |
US4273109A (en) * | 1976-07-06 | 1981-06-16 | Cavitron Corporation | Fiber optic light delivery apparatus and medical instrument utilizing same |
US4176324A (en) | 1976-09-20 | 1979-11-27 | Jersey Nuclear-Avco Isotopes, Inc. | High performance dye laser and flow channel therefor |
JPS5389293A (en) | 1977-01-14 | 1978-08-05 | Olympus Optical Co | High frequency cauterization power supply |
US4122853A (en) | 1977-03-14 | 1978-10-31 | Spectra-Med | Infrared laser photocautery device |
US4327729A (en) | 1977-06-27 | 1982-05-04 | The Procter & Gamble Company | Low-density disposable absorbent bandage having low stretch, wet strength center ply to provide improved pad integrity in use |
US4292601A (en) | 1977-06-29 | 1981-09-29 | Jersey Nuclear-Avco Isotopes, Inc. | Flashlamp excited fluid laser amplifier |
US6603988B2 (en) | 2001-04-13 | 2003-08-05 | Kelsey, Inc. | Apparatus and method for delivering ablative laser energy and determining the volume of tumor mass destroyed |
US4139342A (en) * | 1977-07-18 | 1979-02-13 | Hughes Aircraft Company | Dye impregnated plastics for laser applications |
JPS6043134B2 (en) | 1977-08-25 | 1985-09-26 | 信紘 佐藤 | Device for measuring reflection characteristics of biological organs and tissues |
FR2402320A1 (en) | 1977-09-02 | 1979-03-30 | Anvar | LASER MODE SELECTOR |
US4294263A (en) | 1977-12-07 | 1981-10-13 | Air Shields, Inc. | System for detecting probe dislodgement |
US4188927A (en) * | 1978-01-12 | 1980-02-19 | Valleylab, Inc. | Multiple source electrosurgical generator |
US4228800A (en) | 1978-04-04 | 1980-10-21 | Concept, Inc. | Bipolar electrosurgical knife |
US4254333A (en) | 1978-05-31 | 1981-03-03 | Bergstroem Arne | Optoelectronic circuit element |
DE2826383A1 (en) | 1978-06-16 | 1979-12-20 | Eichler Juergen | Probe for laser surgery - is tubular and placed against or inserted in tissue, with or without heated end |
JPS6058982B2 (en) | 1978-10-13 | 1985-12-23 | 富士写真光機株式会社 | Photostimulation therapy device |
JPS5577187A (en) | 1978-12-05 | 1980-06-10 | Toshiba Corp | Laser oscillating device |
US4313431A (en) * | 1978-12-06 | 1982-02-02 | Messerschmitt-Boelkow-Blohm Gesellschaft Mit Beschraenkter Haftung | Endoscopic apparatus with a laser light conductor |
DE7906381U1 (en) | 1979-03-08 | 1979-07-12 | Richard Wolf Gmbh, 7134 Knittlingen | LIGHTING FOR OPERATIONAL AND EXAMINATION AREAS |
JPS55129327A (en) | 1979-03-28 | 1980-10-07 | Minolta Camera Co Ltd | Constant intensity light emitting strobe device |
US4269067A (en) | 1979-05-18 | 1981-05-26 | International Business Machines Corporation | Method and apparatus for focusing elastic waves converted from thermal energy |
US4302730A (en) | 1979-06-04 | 1981-11-24 | The United States Of America As Represented By The Secretary Of The Navy | Cavity dumper |
FR2465213A1 (en) | 1979-09-13 | 1981-03-20 | Oreal | APPARATUS FOR DIGITAL COLORING OR COLOR MODIFICATION OF AN OBJECT |
US4293827A (en) | 1979-09-14 | 1981-10-06 | Jersey Nuclear-Avco Isotopes, Inc. | Multiwavelength dye laser |
JPS56156150A (en) * | 1980-02-27 | 1981-12-02 | Nato Giyuntaa | Photocoagulator |
US4336809A (en) | 1980-03-17 | 1982-06-29 | Burleigh Instruments, Inc. | Human and animal tissue photoradiation system and method |
US4333197A (en) | 1980-06-02 | 1982-06-08 | Arthur Kuris | Ultrasonic toothbrush |
JPS574007A (en) | 1980-06-07 | 1982-01-09 | Takumi Tomijima | Multiple wavelength light communication system |
US4316467A (en) * | 1980-06-23 | 1982-02-23 | Lorenzo P. Maun | Control for laser hemangioma treatment system |
US4335726A (en) | 1980-07-11 | 1982-06-22 | The Kendall Company | Therapeutic device with temperature and pressure control |
US4375684A (en) * | 1980-07-28 | 1983-03-01 | Jersey Nuclear-Avco Isotopes, Inc. | Laser mode locking, Q-switching and dumping system |
US4428368A (en) * | 1980-09-29 | 1984-01-31 | Masakatsu Torii | Massage device |
US4435808A (en) | 1981-01-22 | 1984-03-06 | Ali Javan | Production of radiation at frequencies of preselected absorbing resonances and methods using same |
FR2498927A1 (en) | 1981-02-05 | 1982-08-06 | Javelle Edmond | APPARATUS FOR HANDLING THE ENERGY CIRCULATING IN THE MERIDIENS OF THE HUMAN BODY |
US4364015A (en) | 1981-03-12 | 1982-12-14 | Jersey Nuclear-Avco Isotopes, Inc. | Compact reservoir system for dye lasers |
US4388924A (en) * | 1981-05-21 | 1983-06-21 | Weissman Howard R | Method for laser depilation |
HU186081B (en) | 1981-09-02 | 1985-05-28 | Fenyo Marta | Process and apparatus for stimulating healing of pathologic points on the surface of the body first of all of wounds, ulcera and other epithelial lesions |
US4559943A (en) | 1981-09-03 | 1985-12-24 | C. R. Bard, Inc. | Electrosurgical generator |
US4445217A (en) | 1981-11-09 | 1984-04-24 | International Laser Systems, Inc. | Laser apparatus and method |
JPS5884482A (en) | 1981-11-13 | 1983-05-20 | Toshiba Corp | Pulse laser device |
JPS5886178A (en) | 1981-11-18 | 1983-05-23 | 松下電器産業株式会社 | Laser medical apparatus |
US4409479A (en) | 1981-12-03 | 1983-10-11 | Xerox Corporation | Optical cursor control device |
US4461294A (en) * | 1982-01-20 | 1984-07-24 | Baron Neville A | Apparatus and process for recurving the cornea of an eye |
US4555786A (en) | 1982-06-24 | 1985-11-26 | Board Of Trustees Of Leland Stanford, Jr. University | High power solid state laser |
GB2123287B (en) | 1982-07-09 | 1986-03-05 | Anna Gunilla Sutton | Depilaton device |
US4489415A (en) | 1982-07-12 | 1984-12-18 | General Electric Company | Pulse pumping an optically pumped laser |
US5928222A (en) | 1982-08-06 | 1999-07-27 | Kleinerman; Marcos Y. | Fiber optic sensing techniques in laser medicine |
US5363463A (en) | 1982-08-06 | 1994-11-08 | Kleinerman Marcos Y | Remote sensing of physical variables with fiber optic systems |
US4889525A (en) | 1982-08-17 | 1989-12-26 | Adamantech, Inc. | Sensitization of hypoxic tumor cells and control of growth thereof |
AU553836B2 (en) | 1982-08-27 | 1986-07-31 | Alistair Joseph Blake | Lamp for irradiating tumours |
US4452081A (en) | 1982-09-30 | 1984-06-05 | Varian Associates, Inc. | Measurement of velocity and tissue temperature by ultrasound |
AU555410B2 (en) * | 1982-10-15 | 1986-09-25 | Asahi Kasei Kogyo Kabushiki Kaisha | Removing salt impurities from sugar syrup or molasses |
US4566271A (en) * | 1982-12-01 | 1986-01-28 | Lucas Industries Public Limited Company | Engine systems |
US4784135A (en) | 1982-12-09 | 1988-11-15 | International Business Machines Corporation | Far ultraviolet surgical and dental procedures |
WO1984002461A1 (en) | 1982-12-28 | 1984-07-05 | Ya Man Ltd | System for automating beauty treatment |
US4504727A (en) | 1982-12-30 | 1985-03-12 | International Business Machines Corporation | Laser drilling system utilizing photoacoustic feedback |
GB8302997D0 (en) | 1983-02-03 | 1983-03-09 | Bergstrom A | Electromagnetic radiation circuit element |
DE3304230A1 (en) | 1983-02-08 | 1984-08-16 | ams Automatische Meß- und Steuerungstechnik GmbH, 8572 Auerbach | RADIATION DEVICE |
US4576177A (en) | 1983-02-18 | 1986-03-18 | Webster Wilton W Jr | Catheter for removing arteriosclerotic plaque |
US5527368C1 (en) | 1983-03-11 | 2001-05-08 | Norton Co | Coated abrasives with rapidly curable adhesives |
US4524289A (en) | 1983-04-11 | 1985-06-18 | Xerox Corporation | Flash lamp power supply with reduced capacitance requirements |
US4601753A (en) | 1983-05-05 | 1986-07-22 | General Electric Company | Powdered iron core magnetic devices |
US4591762A (en) | 1983-05-31 | 1986-05-27 | Olympus Optical, Co. | Electronic flash |
US4773413A (en) | 1983-06-13 | 1988-09-27 | Trimedyne Laser Systems, Inc. | Localized heat applying medical device |
US4662368A (en) | 1983-06-13 | 1987-05-05 | Trimedyne Laser Systems, Inc. | Localized heat applying medical device |
US4503854A (en) | 1983-06-16 | 1985-03-12 | Jako Geza J | Laser surgery |
GB8320639D0 (en) | 1983-07-30 | 1983-09-01 | Emi Plc Thorn | Incandescent lamps |
JPS60123818A (en) * | 1983-12-08 | 1985-07-02 | Olympus Optical Co Ltd | Optical transmitter |
US4512197A (en) | 1983-09-01 | 1985-04-23 | The United States Of America As Represented By The Secretary Of The Navy | Apparatus for generating a focusable and scannable ultrasonic beam for non-destructive examination |
US4608978A (en) * | 1983-09-26 | 1986-09-02 | Carol Block Limited | Method and apparatus for photoepiltion |
US5140984A (en) * | 1983-10-06 | 1992-08-25 | Proclosure, Inc. | Laser healing method and apparatus |
US5409479A (en) | 1983-10-06 | 1995-04-25 | Premier Laser Systems, Inc. | Method for closing tissue wounds using radiative energy beams |
US4862888A (en) | 1983-10-28 | 1989-09-05 | Bausch & Lomb Incorporated | Laser system |
US5108388B1 (en) * | 1983-12-15 | 2000-09-19 | Visx Inc | Laser surgery method |
JPS60148566A (en) | 1984-01-13 | 1985-08-05 | 株式会社東芝 | Laser treatment apparatus |
JPS60148567A (en) * | 1984-01-13 | 1985-08-05 | 株式会社東芝 | Laser treatment apparatus |
US4608979A (en) | 1984-02-22 | 1986-09-02 | Washington Research Foundation | Apparatus for the noninvasive shock fragmentation of renal calculi |
US4569345A (en) * | 1984-02-29 | 1986-02-11 | Aspen Laboratories, Inc. | High output electrosurgical unit |
US4724835A (en) * | 1984-03-06 | 1988-02-16 | Pain Suppression Labs, Inc. | Laser therapeutic device |
US4587968A (en) | 1984-03-19 | 1986-05-13 | Price David R | Electric emasculator and method for castrating |
US4693244A (en) | 1984-05-22 | 1987-09-15 | Surgical Laser Technologies, Inc. | Medical and surgical laser probe I |
US4592353A (en) | 1984-05-22 | 1986-06-03 | Surgical Laser Technologies Ohio, Inc. | Medical and surgical laser probe |
US4601037A (en) | 1984-06-13 | 1986-07-15 | Britt Corporation | Pulsed laser system |
IL75998A0 (en) * | 1984-08-07 | 1985-12-31 | Medical Laser Research & Dev C | Laser system for providing target tissue specific energy deposition |
US4994060A (en) * | 1984-09-17 | 1991-02-19 | Xintec Corporation | Laser heated cautery cap with transparent substrate |
US4848339A (en) | 1984-09-17 | 1989-07-18 | Xintec Corporation | Laser heated intravascular cautery cap assembly |
US4566438A (en) * | 1984-10-05 | 1986-01-28 | Liese Grover J | Fiber-optic stylet for needle tip localization |
US4799479A (en) * | 1984-10-24 | 1989-01-24 | The Beth Israel Hospital Association | Method and apparatus for angioplasty |
ATE51730T1 (en) | 1984-10-25 | 1990-04-15 | Candela Laser Corp | TUNABLE LONG-PULSE DYE LASER. |
US4677347A (en) | 1984-10-26 | 1987-06-30 | Olympus Optical, Co., Ltd. | Electronic flash |
US4656641A (en) | 1985-02-04 | 1987-04-07 | Xerox Corporation | Laser cavity optical system for stabilizing the beam from a phase locked multi-emitter broad emitter laser |
US4638800A (en) * | 1985-02-08 | 1987-01-27 | Research Physics, Inc | Laser beam surgical system |
US4913142A (en) | 1985-03-22 | 1990-04-03 | Massachusetts Institute Of Technology | Catheter for laser angiosurgery |
US5192278A (en) | 1985-03-22 | 1993-03-09 | Massachusetts Institute Of Technology | Multi-fiber plug for a laser catheter |
US5104392A (en) | 1985-03-22 | 1992-04-14 | Massachusetts Institute Of Technology | Laser spectro-optic imaging for diagnosis and treatment of diseased tissue |
US5318024A (en) | 1985-03-22 | 1994-06-07 | Massachusetts Institute Of Technology | Laser endoscope for spectroscopic imaging |
JP2615006B2 (en) | 1985-03-26 | 1997-05-28 | 富士写真光機 株式会社 | Laser beam side fiber |
DE3666773D1 (en) * | 1985-03-29 | 1989-12-14 | Eugene Jim Politzer | Method and apparatus for shaving the beard |
US5346488A (en) | 1985-04-08 | 1994-09-13 | The General Hospital Corporation | Laser-induced ablation of atherosclerotic plaque |
US4887600A (en) | 1986-04-22 | 1989-12-19 | The General Hospital Corporation | Use of lasers to break down objects |
US4623929A (en) | 1985-05-03 | 1986-11-18 | Eastman Kodak Company | Flash tube simmer circuitry for a film video player electronic strobe light |
US4862886A (en) | 1985-05-08 | 1989-09-05 | Summit Technology Inc. | Laser angioplasty |
US4693556A (en) | 1985-06-04 | 1987-09-15 | Laser Therapeutics, Inc. | Apparatus for producing a spherical pattern of light and method of manufacture |
US5196004A (en) * | 1985-07-31 | 1993-03-23 | C. R. Bard, Inc. | Infrared laser catheter system |
EP0214712B1 (en) | 1985-07-31 | 1992-09-02 | C.R. Bard, Inc. | Infrared laser catheter apparatus |
US4917084A (en) * | 1985-07-31 | 1990-04-17 | C. R. Bard, Inc. | Infrared laser catheter system |
US4976709A (en) | 1988-12-15 | 1990-12-11 | Sand Bruce J | Method for collagen treatment |
US5484432A (en) | 1985-09-27 | 1996-01-16 | Laser Biotech, Inc. | Collagen treatment apparatus |
US5137530A (en) * | 1985-09-27 | 1992-08-11 | Sand Bruce J | Collagen treatment apparatus |
US4695697A (en) | 1985-12-13 | 1987-09-22 | Gv Medical, Inc. | Fiber tip monitoring and protection assembly |
GB2184021A (en) * | 1985-12-13 | 1987-06-17 | Micra Ltd | Laser treatment apparatus for port wine stains |
US4910438A (en) | 1985-12-17 | 1990-03-20 | Hughes Aircraft Company | Wide band, high efficiency simmer power supply for a laser flashlamp |
FR2591902B1 (en) | 1985-12-23 | 1989-06-30 | Collin Yvon | EXTERNAL LASER THERAPY APPARATUS HAVING ONE OR MORE LASER DIODES IN SUCTION CUPS |
US4791927A (en) | 1985-12-26 | 1988-12-20 | Allied Corporation | Dual-wavelength laser scalpel background of the invention |
JPS62165985A (en) | 1986-01-17 | 1987-07-22 | Nec Corp | Laser oscillator stabilized at diverging angle of laser beam |
US4735201A (en) | 1986-01-30 | 1988-04-05 | The Beth Israel Hospital Association | Optical fiber with detachable metallic tip for intravascular laser coagulation of arteries, veins, aneurysms, vascular malformations and arteriovenous fistulas |
US4759349A (en) | 1986-02-24 | 1988-07-26 | Vitalmetrics, Inc. | Surgical instrument having a heat sink for irrigation, aspiration, and illumination |
US4871479A (en) | 1986-03-25 | 1989-10-03 | Comurhex Societe Pour La Conversion De L'uranium En Metal Et Hexafluorure | Process for producing sintered mixed oxides which are soluble in nitric acid from solutions of nitrates |
US4775361A (en) | 1986-04-10 | 1988-10-04 | The General Hospital Corporation | Controlled removal of human stratum corneum by pulsed laser to enhance percutaneous transport |
US5336217A (en) | 1986-04-24 | 1994-08-09 | Institut National De La Sante Et De La Recherche Medicale (Insepm) | Process for treatment by irradiating an area of a body, and treatment apparatus usable in dermatology for the treatment of cutaneous angio dysplasias |
CS258312B1 (en) | 1986-04-28 | 1988-08-16 | Karel Hamal | Laser's resonator with radiation frequency change |
FR2597744A1 (en) * | 1986-04-29 | 1987-10-30 | Boussignac Georges | CARDIO-VASCULAR CATHETER FOR LASER SHOOTING |
US4736743A (en) | 1986-05-12 | 1988-04-12 | Surgical Laser Technology, Inc. | Vaporization contact laser probe |
JPS6397175A (en) | 1986-10-15 | 1988-04-27 | 森 敬 | Light irradiation apparatus for emitting tooth germ treating light |
US4826431A (en) | 1986-06-12 | 1989-05-02 | Kabushiki Kaisha Morita Seisakusho | Medical laser handpiece |
US4736745A (en) | 1986-06-27 | 1988-04-12 | University Of Cincinnati | Laser treatment of cancerization of the oral cavity and apparatus for use therewith |
EP0272325A1 (en) | 1986-06-30 | 1988-06-29 | MEDICAL LASER RESEARCH Co., LTD. | Semiconductor laser therapeutic apparatus |
JPS6323648A (en) | 1986-07-17 | 1988-01-30 | 工業技術院長 | Light source device for cancer diagnostic or remedy apparatus |
US4926227A (en) * | 1986-08-01 | 1990-05-15 | Nanometrics Inc. | Sensor devices with internal packaged coolers |
JPH0744141B2 (en) | 1987-09-22 | 1995-05-15 | 株式会社ニコン | Lighting optics |
US4741338A (en) * | 1986-10-06 | 1988-05-03 | Toshiaki Miyamae | Thermoelectric physical remedy apparatus |
US5041109A (en) | 1986-10-27 | 1991-08-20 | University Of Florida | Laser apparatus for the recanalization of vessels and the treatment of other cardiac conditions |
US4860743A (en) | 1986-10-27 | 1989-08-29 | University Of Florida | Laser method and apparatus for the recanalization of vessels and the treatment of other cardiac conditions |
EP0268019A1 (en) | 1986-11-13 | 1988-05-25 | Messerschmitt-Bölkow-Blohm Gesellschaft mit beschränkter Haftung | Apparatus for disintegrating a fluid-suspended solid body |
DE3643284A1 (en) | 1986-12-18 | 1988-06-30 | Aesculap Ag | METHOD AND DEVICE FOR CUTTING A MATERIAL BY MEANS OF A LASER BEAM |
US4779173A (en) | 1986-12-24 | 1988-10-18 | Carr Charlie O | Illuminated brush device |
FR2611000B1 (en) * | 1987-02-12 | 1991-08-16 | Zimmern Bernard | FLOATING PINION WITH SPRING FOR VOLUMETRIC MACHINE |
US4840563A (en) | 1987-02-26 | 1989-06-20 | Siemens Aktiengesellschaft | Dental equipment having means for delivering RF and LF energy to a dental handpiece |
US5057099A (en) | 1987-02-27 | 1991-10-15 | Xintec Corporation | Method for laser surgery |
US5092865A (en) | 1987-02-27 | 1992-03-03 | Xintec Corporation | Optical fiber fault detector |
JPS63216579A (en) | 1987-03-05 | 1988-09-08 | 大工園 則雄 | Laser beam irradiation apparatus for hyperthermia |
JPS63249577A (en) | 1987-04-06 | 1988-10-17 | 浜理薬品工業株式会社 | Permanent hair removing method, preparation and device |
DE8705296U1 (en) | 1987-04-09 | 1988-08-04 | Heimann Gmbh, 6200 Wiesbaden, De | |
US4749913A (en) | 1987-04-17 | 1988-06-07 | General Electric Company | Operating circuit for a direct current discharge lamp |
US4901323A (en) * | 1987-05-01 | 1990-02-13 | Universities Research Association, Inc. | Laser pulse stretcher method and apparatus |
US4745909A (en) | 1987-05-15 | 1988-05-24 | Pelton Robert J | Cold massage tool and method of use thereof |
JPS6427554A (en) | 1987-07-22 | 1989-01-30 | Morita Mfg | Medical laser irradiation apparatus |
JPH01178256A (en) | 1988-01-05 | 1989-07-14 | Hideo Suyama | Electronic toothbrush |
EP0311295A3 (en) | 1987-10-07 | 1990-02-28 | University College London | Improvements in surgical apparatus |
US4862903A (en) | 1987-10-09 | 1989-09-05 | U.S. Divers Company, Inc. | Breathing mouthpiece for contacting upper palate and lower jaw of user's mouth |
JPH0199574A (en) | 1987-10-13 | 1989-04-18 | Matsushita Electric Ind Co Ltd | Medical equipment with semiconductor laser |
US4860744A (en) * | 1987-11-02 | 1989-08-29 | Raj K. Anand | Thermoelectrically controlled heat medical catheter |
IL84367A (en) | 1987-11-04 | 1994-02-27 | Amcor Ltd | Apparatus for use in radiation therapy |
US4930504A (en) | 1987-11-13 | 1990-06-05 | Diamantopoulos Costas A | Device for biostimulation of tissue and method for treatment of tissue |
US4845608A (en) | 1987-12-21 | 1989-07-04 | General Electric Company | Digital speed controller using a single-chip microcontroller |
JPH01181877A (en) | 1988-01-14 | 1989-07-19 | Matsushita Electric Ind Co Ltd | Laser medical treatment device |
US4860172A (en) * | 1988-01-19 | 1989-08-22 | Biotronics Associates, Inc. | Lamp-based laser simulator |
US5112328A (en) | 1988-01-25 | 1992-05-12 | Refractive Laser Research & Development Program, Ltd. | Method and apparatus for laser surgery |
US4931053A (en) | 1988-01-27 | 1990-06-05 | L'esperance Medical Technologies, Inc. | Method and apparatus for enhanced vascular or other growth |
US4898439A (en) * | 1988-02-10 | 1990-02-06 | Kei Mori | Light radiation device for use in medical treatment |
US4813762A (en) | 1988-02-11 | 1989-03-21 | Massachusetts Institute Of Technology | Coherent beam combining of lasers using microlenses and diffractive coupling |
US4977571A (en) | 1988-03-29 | 1990-12-11 | Candela Laser Corporation | Dye laser solution circulation system |
US5061266A (en) | 1988-03-30 | 1991-10-29 | Hakky Said I | Laser resectoscope and method |
US5201731A (en) | 1988-03-30 | 1993-04-13 | Hakky Said I | Laser resectoscope with ultransonic imaging means |
US4955882A (en) | 1988-03-30 | 1990-09-11 | Hakky Said I | Laser resectoscope with mechanical and laser cutting means |
EP0413025A4 (en) | 1988-06-04 | 1991-05-22 | Sumitomo Electric Industries, Ltd | Laser-aided intravascular operation equipment |
US5242437A (en) | 1988-06-10 | 1993-09-07 | Trimedyne Laser Systems, Inc. | Medical device applying localized high intensity light and heat, particularly for destruction of the endometrium |
US4891817A (en) * | 1988-06-13 | 1990-01-02 | Eastman Kodak Company | Pulsed dye laser apparatus for high PRF operation |
JPH022199A (en) | 1988-06-14 | 1990-01-08 | Toshiba Corp | Dye circulator of dye laser |
DE8807746U1 (en) | 1988-06-15 | 1988-09-29 | Messerschmitt-Boelkow-Blohm Gmbh, 8012 Ottobrunn, De | |
JPH0734542B2 (en) | 1988-06-29 | 1995-04-12 | 日本電気株式会社 | D-A conversion circuit |
JPH0213479A (en) * | 1988-07-01 | 1990-01-17 | Takashi Mori | Light radiation device for medical therapy |
US4884560A (en) | 1988-07-11 | 1989-12-05 | Kuracina Thomas C | Thermal massage device |
GB8816648D0 (en) | 1988-07-13 | 1988-08-17 | Rowland A C | Light delivery system |
US4890898A (en) * | 1988-08-18 | 1990-01-02 | Hgm Medical Laser Systems, Inc. | Composite microsize optical fiber-electric lead cable |
US5037421A (en) | 1989-10-06 | 1991-08-06 | Coherent, Inc., Medical Group | Mid-infrared laser arthroscopic procedure |
US4878224A (en) | 1988-09-16 | 1989-10-31 | Hoechst Celanese Corporation | Dye lasers |
JPH0288080A (en) | 1988-09-26 | 1990-03-28 | Takashi Mori | Light irradiation medical curing tool |
US4928038A (en) | 1988-09-26 | 1990-05-22 | General Electric Company | Power control circuit for discharge lamp and method of operating same |
DE3837248A1 (en) | 1988-10-28 | 1990-05-03 | Teichmann Heinrich Otto Dr Phy | Device for treating skin lesions |
US5191883A (en) | 1988-10-28 | 1993-03-09 | Prutech Research And Development Partnership Ii | Device for heating tissue in a patient's body |
EP0368512A3 (en) | 1988-11-10 | 1990-08-08 | Premier Laser Systems, Inc. | Multiwavelength medical laser system |
DE3841503A1 (en) | 1988-12-09 | 1990-06-28 | Wrobel Walter G Dr | Method and device for removing dental tissue |
JP2683565B2 (en) | 1988-12-12 | 1997-12-03 | 則雄 大工園 | Laser light transmitting body and method of manufacturing the same |
JPH02174804A (en) | 1988-12-27 | 1990-07-06 | Hiroshi Fukuba | Toothbrush device of mouth lightening type |
US4860303A (en) | 1989-01-17 | 1989-08-22 | The United States Of America As Represented By The Secretary Of The Army | Double-sided co-axial laser |
JP2592791B2 (en) | 1989-01-31 | 1997-03-19 | 株式会社サンギ | Electronic toothbrush |
US5006293A (en) | 1989-02-02 | 1991-04-09 | Owens-Corning Fiberglas Corporation | Process for forming flat plate ballistic resistant materials |
JP2779825B2 (en) | 1989-02-15 | 1998-07-23 | 則雄 大工園 | Laser light emitting device |
US5425735A (en) | 1989-02-22 | 1995-06-20 | Psi Medical Products, Inc. | Shielded tip catheter for lithotripsy |
EP0387755A1 (en) | 1989-03-17 | 1990-09-19 | Schott Glaswerke | Catheter system for revascularisation in the human body |
US4945239A (en) * | 1989-03-29 | 1990-07-31 | Center For Innovative Technology | Early detection of breast cancer using transillumination |
US5207576A (en) | 1989-04-07 | 1993-05-04 | American Dental Laser, Inc. | Dental laser assembly with dual lasers |
US5009658A (en) | 1989-04-14 | 1991-04-23 | Karl Storz Endoscopy-America, Inc. | Dual frequency laser lithotripter |
US5421337A (en) | 1989-04-14 | 1995-06-06 | Massachusetts Institute Of Technology | Spectral diagnosis of diseased tissue |
US5263951A (en) | 1989-04-21 | 1993-11-23 | Kerus Medical Systems | Correction of the optical focusing system of the eye using laser thermal keratoplasty |
US5180378A (en) * | 1989-04-24 | 1993-01-19 | Abiomed, Inc. | Laser surgery system |
JPH02285694A (en) | 1989-04-26 | 1990-11-22 | Toshiba Corp | Dye laser |
WO1990013333A1 (en) | 1989-05-03 | 1990-11-15 | Intra-Sonix, Inc. | Instrument and method for intraluminally relieving stenosis |
CN2053926U (en) | 1989-05-06 | 1990-03-07 | 李杰生 | Radiation treatment apparatus |
US5057104A (en) | 1989-05-30 | 1991-10-15 | Cyrus Chess | Method and apparatus for treating cutaneous vascular lesions |
US5486172A (en) * | 1989-05-30 | 1996-01-23 | Chess; Cyrus | Apparatus for treating cutaneous vascular lesions |
US4896329A (en) * | 1989-06-01 | 1990-01-23 | Exciton Incorporated | Laser dye liquids, laser dye instruments and methods |
US5152759A (en) * | 1989-06-07 | 1992-10-06 | University Of Miami, School Of Medicine, Dept. Of Ophthalmology | Noncontact laser microsurgical apparatus |
US5207673A (en) | 1989-06-09 | 1993-05-04 | Premier Laser Systems, Inc. | Fiber optic apparatus for use with medical lasers |
JPH0319385A (en) | 1989-06-16 | 1991-01-28 | Mitsubishi Electric Corp | Dye laser device |
JP2752439B2 (en) | 1989-06-20 | 1998-05-18 | 株式会社リコー | Image output method |
US5011483A (en) | 1989-06-26 | 1991-04-30 | Dennis Sleister | Combined electrosurgery and laser beam delivery device |
JPH0627172Y2 (en) | 1989-07-04 | 1994-07-27 | 東京医研株式会社 | Infrared treatment device for physical examination |
FR2650196B1 (en) | 1989-07-06 | 1991-12-06 | Technomed Internat | METHOD AND APPARATUS FOR REGENERATING A DYE SOLUTION IN A DILUENT, IN PARTICULAR A DYE SOLUTION FOR A DYE LASER |
US4973848A (en) | 1989-07-28 | 1990-11-27 | J. Mccaughan | Laser apparatus for concurrent analysis and treatment |
US5955490A (en) | 1989-07-28 | 1999-09-21 | Queen's University At Kingston | Photochemotherapeutic method using 5-aminolevulinic acid and other precursors of endogenous porphyrins |
JP2854027B2 (en) | 1989-08-03 | 1999-02-03 | ヤーマン株式会社 | Light hair removal device |
JPH0373106A (en) | 1989-08-14 | 1991-03-28 | Omron Corp | Optical medical toothbrush |
WO1991002562A1 (en) | 1989-08-17 | 1991-03-07 | Surgical Laser Products, Inc. | Integral end structure for medical laser waveguide |
JP2882814B2 (en) | 1989-08-24 | 1999-04-12 | 株式会社エス・エル・ティ・ジャパン | Laser irradiation equipment |
JP3069108B2 (en) | 1989-09-01 | 2000-07-24 | 株式会社エス・エル・ティ・ジャパン | Laser light emitting device |
JP3046315B2 (en) | 1989-09-05 | 2000-05-29 | 株式会社エス・エル・ティ・ジャパン | Laser irradiation equipment |
US4972427A (en) | 1989-09-14 | 1990-11-20 | Spectra Diode Laboratories, Inc. | Talbot cavity diode laser with uniform single-mode output |
US5182557A (en) * | 1989-09-20 | 1993-01-26 | Semborg Recrob, Corp. | Motorized joystick |
US4992256A (en) | 1989-09-27 | 1991-02-12 | Colgate-Palmolive Company | Plaque disclosing compositions |
US5404001A (en) | 1992-10-08 | 1995-04-04 | Bard; Simon | Fiber optic barcode reader |
US5027359A (en) | 1989-10-30 | 1991-06-25 | Massachusetts Institute Of Technology | Miniature Talbot cavity for lateral mode control of laser array |
DE3936367A1 (en) * | 1989-11-02 | 1991-05-08 | Simon Pal | SHAVER |
US5369496A (en) | 1989-11-13 | 1994-11-29 | Research Foundation Of City College Of New York | Noninvasive method and apparatus for characterizing biological materials |
US5129896A (en) | 1989-11-13 | 1992-07-14 | Hasson Harrith M | Holder to facilitate use of a laser in surgical procedures |
US4979180A (en) | 1989-11-24 | 1990-12-18 | Muncheryan Arthur M | Modular interchangeable laser system |
GB2239675A (en) | 1989-12-05 | 1991-07-10 | Man Fai Shiu | Pump for pumping liquid |
JPH03183184A (en) | 1989-12-13 | 1991-08-09 | Toshiba Corp | Monitor for dye deterioration of ring dye laser oscillator |
FR2655849B1 (en) | 1989-12-19 | 1997-10-31 | Raymond Bontemps | LOCAL CRYOGENIC DEVICE FOR MASSAGE OF THE SKIN. |
JP3148216B2 (en) | 1990-01-22 | 2001-03-19 | 株式会社エス・エル・ティ・ジャパン | Treatment equipment by laser beam irradiation |
US5261904A (en) | 1990-01-30 | 1993-11-16 | C. R. Bard, Inc. | Laser catheter having diffraction grating for beam shaping |
US5032178A (en) | 1990-02-02 | 1991-07-16 | Demetron Research Corporation | Dental composition system and method for bleaching teeth |
GB2242307B (en) | 1990-02-09 | 1994-09-07 | Omega Universal Tech Ltd | Laser probe for biomodulation of tissue nerve and immune systems |
US4976308A (en) | 1990-02-21 | 1990-12-11 | Wright State University | Thermal energy storage heat exchanger |
US5102410A (en) | 1990-02-26 | 1992-04-07 | Dressel Thomas D | Soft tissue cutting aspiration device and method |
WO1991013652A1 (en) | 1990-03-14 | 1991-09-19 | Candela Laser Corporation | Apparatus for treating abnormal pigmentation of the skin |
US5147353A (en) | 1990-03-23 | 1992-09-15 | Myriadlase, Inc. | Medical method for applying high energy light and heat for gynecological sterilization procedures |
SE465953B (en) * | 1990-04-09 | 1991-11-25 | Morgan Gustafsson | DEVICE FOR TREATMENT OF UNDESECTED EXTERNAL ACCOMMODATIONS |
US5059192A (en) | 1990-04-24 | 1991-10-22 | Nardo Zaias | Method of hair depilation |
US5071416A (en) | 1990-05-02 | 1991-12-10 | Metalaser Technologies, Inc. | Method of and apparatus for laser-assisted therapy |
US5080660A (en) * | 1990-05-11 | 1992-01-14 | Applied Urology, Inc. | Electrosurgical electrode |
JP2917413B2 (en) | 1990-05-23 | 1999-07-12 | ソニー株式会社 | Solid state laser oscillator |
US5060243A (en) | 1990-05-29 | 1991-10-22 | Motorola, Inc. | Ripple counter with reverse-propagated zero detection |
GB9011998D0 (en) | 1990-05-30 | 1990-07-18 | Omega Universal Tech Ltd | A device and method for laser photothermotherapy |
US5725522A (en) | 1990-06-15 | 1998-03-10 | Rare Earth Medical, Inc. | Laser suturing of biological materials |
US5071417A (en) | 1990-06-15 | 1991-12-10 | Rare Earth Medical Lasers, Inc. | Laser fusion of biological materials |
AU642266B2 (en) | 1990-06-25 | 1993-10-14 | Kevin John Bourke | Method and apparatus for dental treatment |
US5197470A (en) | 1990-07-16 | 1993-03-30 | Eastman Kodak Company | Near infrared diagnostic method and instrument |
US5046494A (en) | 1990-08-27 | 1991-09-10 | John Searfoss | Phototherapy method |
US5312396A (en) | 1990-09-06 | 1994-05-17 | Massachusetts Institute Of Technology | Pulsed laser system for the surgical removal of tissue |
DE4032471C2 (en) | 1990-10-12 | 1997-02-06 | Delma Elektro Med App | Electrosurgical device |
DE4032860A1 (en) | 1990-10-12 | 1992-04-16 | Zeiss Carl Fa | POWER-CONTROLLED CONTACT APPLICATOR FOR LASER RADIATION |
US5472748A (en) | 1990-10-15 | 1995-12-05 | The United States Of America As Represented By The United States Department Of Energy | Permanent laser conditioning of thin film optical materials |
US5190541A (en) | 1990-10-17 | 1993-03-02 | Boston Scientific Corporation | Surgical instrument and method |
US5354324A (en) | 1990-10-18 | 1994-10-11 | The General Hospital Corporation | Laser induced platelet inhibition |
US5269777A (en) | 1990-11-01 | 1993-12-14 | Pdt Systems, Inc. | Diffusion tip for optical fibers |
US5257991A (en) | 1990-11-15 | 1993-11-02 | Laserscope | Instrumentation for directing light at an angle |
US5549660A (en) | 1990-11-15 | 1996-08-27 | Amron, Ltd. | Method of treating acne |
US5109387A (en) | 1990-12-26 | 1992-04-28 | Garden Jerome M | Dye laser system and method |
US5056515A (en) | 1991-01-04 | 1991-10-15 | Abel Elaine R | Tracheostomy tube assembly |
DE4100442C2 (en) | 1991-01-09 | 1994-02-10 | Texas Instruments Deutschland | Arrangement for monitoring operating parameters of pneumatic tires of a vehicle mounted on wheel rims |
US5090019A (en) * | 1991-01-10 | 1992-02-18 | The United States Of America As Represented By The Secretary Of The Navy | Laser diode-pumped tunable solid state laser |
US5488626A (en) * | 1991-01-14 | 1996-01-30 | Light Age, Inc. | Method of and apparatus for pumping of transition metal ion containing solid state lasers using diode laser sources |
US5065515A (en) | 1991-01-24 | 1991-11-19 | Warner-Lambert Company | Thermally assisted shaving system |
US6405072B1 (en) | 1991-01-28 | 2002-06-11 | Sherwood Services Ag | Apparatus and method for determining a location of an anatomical target with reference to a medical apparatus |
US5300097A (en) * | 1991-02-13 | 1994-04-05 | Lerner Ethan A | Fiber optic psoriasis treatment device |
US5132980A (en) | 1991-02-13 | 1992-07-21 | Coherent, Inc. | Method and device for preconditioning a laser having a solid state gain medium |
US5163935A (en) | 1991-02-20 | 1992-11-17 | Reliant Laser Corporation | Surgical laser endoscopic focusing guide with an optical fiber link |
DE9102407U1 (en) | 1991-02-28 | 1991-07-11 | Mink, Mathias, 7570 Baden-Baden, De | |
IL97531A (en) | 1991-03-12 | 1995-12-31 | Kelman Elliot | Hair cutting apparatus |
US5492894A (en) * | 1991-03-21 | 1996-02-20 | The Procter & Gamble Company | Compositions for treating wrinkles comprising a peptide |
US5369831A (en) | 1991-03-25 | 1994-12-06 | Sonex International Corporation | Therapeutic ultrasonic toothbrush |
US5207671A (en) * | 1991-04-02 | 1993-05-04 | Franken Peter A | Laser debridement of wounds |
US5147356A (en) | 1991-04-16 | 1992-09-15 | Microsurge, Inc. | Surgical instrument |
US5242438A (en) | 1991-04-22 | 1993-09-07 | Trimedyne, Inc. | Method and apparatus for treating a body site with laterally directed laser radiation |
GB9108777D0 (en) | 1991-04-24 | 1991-06-12 | Vuman Ltd | A dermatological laser |
US6485413B1 (en) | 1991-04-29 | 2002-11-26 | The General Hospital Corporation | Methods and apparatus for forward-directed optical scanning instruments |
US5300063A (en) | 1991-05-11 | 1994-04-05 | Nidek Co., Ltd. | Ophthalmic laser apparatus |
US5140608A (en) | 1991-05-29 | 1992-08-18 | Optrotech Ltd, Israel Company | Optical system for focusing a light beam on to an image plane |
DE4118610A1 (en) | 1991-06-06 | 1992-12-10 | Siemens Ag | Coupling device for introducing acoustic waves into the body of a living being |
US5484436A (en) * | 1991-06-07 | 1996-01-16 | Hemostatic Surgery Corporation | Bi-polar electrosurgical instruments and methods of making |
JP3274691B2 (en) | 1991-06-14 | 2002-04-15 | 並木精密宝石株式会社 | Manufacturing method of optical fiber terminal with micro lens |
RU2122848C1 (en) | 1991-06-24 | 1998-12-10 | Учебно-научно-производственный лазерный центр Санкт-Петербургского института точной механики и оптики | Reflexotherapy device |
US5249192A (en) | 1991-06-27 | 1993-09-28 | Laserscope | Multiple frequency medical laser |
US5320620A (en) | 1991-07-01 | 1994-06-14 | Laser Centers Of America | Laser surgical device with blunt flat-sided energy-delivery element |
DE4122219A1 (en) | 1991-07-04 | 1993-01-07 | Delma Elektro Med App | ELECTRO-SURGICAL TREATMENT INSTRUMENT |
US5474549A (en) | 1991-07-09 | 1995-12-12 | Laserscope | Method and system for scanning a laser beam for controlled distribution of laser dosage |
US5178617A (en) * | 1991-07-09 | 1993-01-12 | Laserscope | System for controlled distribution of laser dosage |
US5331649A (en) | 1991-07-10 | 1994-07-19 | Alson Surgical, Inc. | Multiple wavelength laser system |
US5159601A (en) | 1991-07-17 | 1992-10-27 | General Instrument Corporation | Method for producing a tunable erbium fiber laser |
US5217455A (en) | 1991-08-12 | 1993-06-08 | Tan Oon T | Laser treatment method for removing pigmentations, lesions, and abnormalities from the skin of a living human |
JP2754964B2 (en) | 1991-08-13 | 1998-05-20 | 日本電気株式会社 | Multi-pole connector mating structure |
US5254114A (en) | 1991-08-14 | 1993-10-19 | Coherent, Inc. | Medical laser delivery system with internally reflecting probe and method |
US5370649A (en) | 1991-08-16 | 1994-12-06 | Myriadlase, Inc. | Laterally reflecting tip for laser transmitting fiber |
US5225926A (en) * | 1991-09-04 | 1993-07-06 | International Business Machines Corporation | Durable optical elements fabricated from free standing polycrystalline diamond and non-hydrogenated amorphous diamond like carbon (dlc) thin films |
US5267399A (en) | 1991-09-09 | 1993-12-07 | Johnston William A | Implement for simultaneous skin chilling and chilled gel application |
US5171564A (en) | 1991-09-13 | 1992-12-15 | Colgate-Palmolive | Aqueous tooth whitening dentifrice |
US5370642A (en) * | 1991-09-25 | 1994-12-06 | Keller; Gregory S. | Method of laser cosmetic surgery |
AU2414392A (en) | 1991-09-26 | 1993-04-27 | Warner-Lambert Company | Hair ablation system by optical irradiation |
US5255277A (en) | 1991-09-30 | 1993-10-19 | Whittaker Ordnance, Inc. | Electronic pulse width controller for flashlamp pumped lasers |
US5293880A (en) | 1991-10-02 | 1994-03-15 | Levitt Steven J | Athletic mouthguard |
US5222953A (en) | 1991-10-02 | 1993-06-29 | Kambiz Dowlatshahi | Apparatus for interstitial laser therapy having an improved temperature sensor for tissue being treated |
US5439954A (en) | 1991-10-11 | 1995-08-08 | The Procter & Gamble Company | Substituted phenyl-1,3-diketones as protectants against skin damage |
US6461296B1 (en) | 1998-06-26 | 2002-10-08 | 2000 Injectx, Inc. | Method and apparatus for delivery of genes, enzymes and biological agents to tissue cells |
US5871480A (en) | 1991-10-29 | 1999-02-16 | Thermolase Corporation | Hair removal using photosensitizer and laser |
US5423803A (en) | 1991-10-29 | 1995-06-13 | Thermotrex Corporation | Skin surface peeling process using laser |
US5425728A (en) * | 1991-10-29 | 1995-06-20 | Tankovich; Nicolai I. | Hair removal device and method |
US5817089A (en) | 1991-10-29 | 1998-10-06 | Thermolase Corporation | Skin treatment process using laser |
US5226907A (en) * | 1991-10-29 | 1993-07-13 | Tankovich Nikolai I | Hair removal device and method |
US5303585A (en) | 1991-10-31 | 1994-04-19 | Jtl Medical Corporation | Fluid volume sensor |
US5213092A (en) | 1991-10-31 | 1993-05-25 | Martin Uram | Aspirating endoscope |
ATE241938T1 (en) | 1991-11-08 | 2003-06-15 | Boston Scient Ltd | ABLATION ELECTRODE WITH INSULATED TEMPERATURE MEASUREMENT ELEMENT |
US7198046B1 (en) | 1991-11-14 | 2007-04-03 | Wake Forest University Health Sciences | Wound treatment employing reduced pressure |
DE4138116A1 (en) | 1991-11-19 | 1993-06-03 | Delma Elektro Med App | MEDICAL HIGH-FREQUENCY COAGULATION CUTTER |
US5344418A (en) * | 1991-12-12 | 1994-09-06 | Shahriar Ghaffari | Optical system for treatment of vascular lesions |
US5246436A (en) | 1991-12-18 | 1993-09-21 | Alcon Surgical, Inc. | Midinfrared laser tissue ablater |
US5275596A (en) * | 1991-12-23 | 1994-01-04 | Laser Centers Of America | Laser energy delivery tip element with throughflow of vaporized materials |
US5219347A (en) | 1991-12-24 | 1993-06-15 | Laser Engineering, Inc. | Decoupled dual-beam control system |
CN1073607A (en) | 1991-12-28 | 1993-06-30 | 王文辉 | Electrotherapeutic toothbrush |
IL100545A (en) | 1991-12-29 | 1995-03-15 | Dimotech Ltd | Apparatus for photodynamic therapy treatment |
US5501680A (en) | 1992-01-15 | 1996-03-26 | The University Of Pittsburgh | Boundary and proximity sensor apparatus for a laser |
US5353790A (en) | 1992-01-17 | 1994-10-11 | Board Of Regents, The University Of Texas System | Method and apparatus for optical measurement of bilirubin in tissue |
US5830209A (en) | 1992-02-05 | 1998-11-03 | Angeion Corporation | Multi-fiber laser catheter |
WO1993015676A1 (en) | 1992-02-05 | 1993-08-19 | Angelase, Inc. | Laser catheter with movable integral fixation wire |
US5160194A (en) | 1992-02-27 | 1992-11-03 | Feldman Melvin D | Toothbrush with externally illuminated bristles |
US5591219A (en) | 1992-03-06 | 1997-01-07 | Dungan; Thomas E. | Frequency modulator |
DE4207463C2 (en) | 1992-03-10 | 1996-03-28 | Siemens Ag | Arrangement for the therapy of tissue with ultrasound |
GB2270159A (en) | 1992-03-13 | 1994-03-02 | Scient Generics Ltd | Optically controlled ultrasound array |
WO1993018715A1 (en) | 1992-03-20 | 1993-09-30 | The General Hospital Corporation | Laser illuminator |
US5281216A (en) * | 1992-03-31 | 1994-01-25 | Valleylab, Inc. | Electrosurgical bipolar treating apparatus |
DE9204621U1 (en) | 1992-04-03 | 1992-07-30 | Oralia Dentalprodukte Gmbh, 7750 Konstanz, De | |
CA2093055C (en) | 1992-04-09 | 2002-02-19 | Shimon Eckhouse | Method and apparatus for therapeutic electromagnetic treatment |
US5257970A (en) | 1992-04-09 | 1993-11-02 | Health Research, Inc. | In situ photodynamic therapy |
US5405368A (en) | 1992-10-20 | 1995-04-11 | Esc Inc. | Method and apparatus for therapeutic electromagnetic treatment |
US5540681A (en) | 1992-04-10 | 1996-07-30 | Medtronic Cardiorhythm | Method and system for radiofrequency ablation of tissue |
US5349590A (en) | 1992-04-10 | 1994-09-20 | Premier Laser Systems, Inc. | Medical laser apparatus for delivering high power infrared light |
US5284153A (en) * | 1992-04-14 | 1994-02-08 | Brigham And Women's Hospital | Method for locating a nerve and for protecting nerves from injury during surgery |
US5287372A (en) | 1992-04-24 | 1994-02-15 | Hughes Aircraft Company | Quasi-resonant diode drive current source |
US5755752A (en) | 1992-04-24 | 1998-05-26 | Segal; Kim Robin | Diode laser irradiation system for biological tissue stimulation |
JP4564596B2 (en) | 1992-04-30 | 2010-10-20 | ユーシーエル ビジネス ピーエルシー | Laser treatment |
US5308311A (en) | 1992-05-01 | 1994-05-03 | Robert F. Shaw | Electrically heated surgical blade and methods of making |
WO1993021843A1 (en) | 1992-05-05 | 1993-11-11 | Coherent, Inc. | Device and method for variably blending multiple laser beams for medical purposes |
DE69221130T2 (en) | 1992-05-06 | 1998-04-09 | 600 Uk Ltd | System for combining laser beams |
US5334191A (en) * | 1992-05-21 | 1994-08-02 | Dix Phillip Poppas | Laser tissue welding control system |
US5507739A (en) | 1992-06-15 | 1996-04-16 | American Dental Technologies, Inc. | Dental laser |
US5290274A (en) | 1992-06-16 | 1994-03-01 | Laser Medical Technology, Inc. | Laser apparatus for medical and dental treatments |
JPH0622871A (en) | 1992-07-03 | 1994-02-01 | Hideyo Niida | Toothbrush case with sterilamp |
US5292320A (en) | 1992-07-06 | 1994-03-08 | Ceramoptec, Inc. | Radial medical laser delivery device |
EP0920840A3 (en) | 1992-07-31 | 2000-03-29 | Molten Corporation | Small-sized light irradiator for dental use |
US5596619A (en) | 1992-08-21 | 1997-01-21 | Nomos Corporation | Method and apparatus for conformal radiation therapy |
US5267995A (en) | 1992-09-01 | 1993-12-07 | Pdt Systems | Optical waveguide with flexible tip |
CA2143639C (en) * | 1992-09-01 | 2004-07-20 | Edwin L. Adair | Sterilizable endoscope with separable disposable tube assembly |
DE69311478T2 (en) | 1992-09-07 | 1998-01-02 | Philips Electronics Nv | Method for producing a block-shaped carrier body for a semiconductor component |
DE4232915A1 (en) | 1992-10-01 | 1994-04-07 | Hohla Kristian | Device for shaping the cornea by removing tissue |
US5336221A (en) | 1992-10-14 | 1994-08-09 | Premier Laser Systems, Inc. | Method and apparatus for applying thermal energy to tissue using a clamp |
US5306143A (en) | 1992-10-15 | 1994-04-26 | Laser Medical Technology, Inc. | Dental hygiene appliance |
US5423800A (en) | 1992-10-19 | 1995-06-13 | The University Of Miami | Laser scleral buckling method and instruments therefor |
US5620478A (en) * | 1992-10-20 | 1997-04-15 | Esc Medical Systems Ltd. | Method and apparatus for therapeutic electromagnetic treatment |
US5683380A (en) | 1995-03-29 | 1997-11-04 | Esc Medical Systems Ltd. | Method and apparatus for depilation using pulsed electromagnetic radiation |
US5626631A (en) * | 1992-10-20 | 1997-05-06 | Esc Medical Systems Ltd. | Method and apparatus for therapeutic electromagnetic treatment |
US6280438B1 (en) * | 1992-10-20 | 2001-08-28 | Esc Medical Systems Ltd. | Method and apparatus for electromagnetic treatment of the skin, including hair depilation |
US5720772A (en) * | 1992-10-20 | 1998-02-24 | Esc Medical Systems Ltd. | Method and apparatus for therapeutic electromagnetic treatment |
GB2272278B (en) * | 1992-10-23 | 1997-04-09 | Cancer Res Campaign Tech | Light source |
WO1995022283A1 (en) * | 1992-10-26 | 1995-08-24 | Ultrasonic Sensing & Monitoring Systems, Inc. | Catheter using optical fibers to transmit laser and ultrasonic energy |
WO1994009694A1 (en) | 1992-10-28 | 1994-05-11 | Arsenault, Dennis, J. | Electronic endoscope |
US5300065A (en) | 1992-11-06 | 1994-04-05 | Proclosure Inc. | Method and apparatus for simultaneously holding and sealing tissue |
US5334193A (en) * | 1992-11-13 | 1994-08-02 | American Cardiac Ablation Co., Inc. | Fluid cooled ablation catheter |
AU5456494A (en) * | 1992-11-13 | 1994-06-08 | American Cardiac Ablation Co., Inc. | Fluid cooled electrosurgical probe |
US5540678A (en) | 1992-12-31 | 1996-07-30 | Laser Centers Of America | Apparatus and method for efficiently transmitting optic energy from a reuseable optic element to a disposable optic element |
US5342358A (en) | 1993-01-12 | 1994-08-30 | S.L.T. Japan Co., Ltd. | Apparatus for operation by laser energy |
US5354294A (en) | 1993-05-26 | 1994-10-11 | Xintec Corporation | Combination reflectance fiber optic laser beam angle delivery |
US5366456A (en) | 1993-02-08 | 1994-11-22 | Xintec Corporation | Angle firing fiber optic laser scalpel and method of use |
US5287380A (en) | 1993-02-19 | 1994-02-15 | Candela Laser Corporation | Method and apparatus for generating long output pulses from flashlamp-excited lasers |
US5527350A (en) | 1993-02-24 | 1996-06-18 | Star Medical Technologies, Inc. | Pulsed infrared laser treatment of psoriasis |
US5707403A (en) * | 1993-02-24 | 1998-01-13 | Star Medical Technologies, Inc. | Method for the laser treatment of subsurface blood vessels |
US5356081A (en) | 1993-02-24 | 1994-10-18 | Electric Power Research Institute, Inc. | Apparatus and process for employing synergistic destructive powers of a water stream and a laser beam |
US5368038A (en) | 1993-03-08 | 1994-11-29 | Thermoscan Inc. | Optical system for an infrared thermometer |
DE9303352U1 (en) | 1993-03-08 | 1993-07-22 | Elfo Ag Sachseln, Sachseln, Ch | |
US5387211B1 (en) | 1993-03-10 | 1996-12-31 | Trimedyne Inc | Multi-head laser assembly |
US5304170A (en) * | 1993-03-12 | 1994-04-19 | Green Howard A | Method of laser-induced tissue necrosis in carotenoid-containing skin structures |
US5350376A (en) | 1993-04-16 | 1994-09-27 | Ceramoptec, Inc. | Optical controller device |
GB9309397D0 (en) | 1993-05-07 | 1993-06-23 | Patel Bipin C M | Laser treatment |
US5421339A (en) | 1993-05-12 | 1995-06-06 | Board Of Regents, The University Of Texas System | Diagnosis of dysplasia using laser induced fluoroescence |
US5628771A (en) | 1993-05-12 | 1997-05-13 | Olympus Optical Co., Ltd. | Electromagnetic-wave thermatological device |
US5454807A (en) | 1993-05-14 | 1995-10-03 | Boston Scientific Corporation | Medical treatment of deeply seated tissue using optical radiation |
US5395356A (en) | 1993-06-04 | 1995-03-07 | Summit Technology, Inc. | Correction of presbyopia by photorefractive keratectomy |
US5403306A (en) * | 1993-06-22 | 1995-04-04 | Vanderbilt University | Laser surgery method |
DE4323585A1 (en) | 1993-07-14 | 1995-01-19 | Delma Elektro Med App | Bipolar high-frequency surgical instrument |
US5860967A (en) | 1993-07-21 | 1999-01-19 | Lucid, Inc. | Dermatological laser treatment system with electronic visualization of the area being treated |
US5668824A (en) | 1993-07-28 | 1997-09-16 | Cynosure, Inc. | Method and apparatus for replenishing dye solution in a dye laser |
US5445608A (en) | 1993-08-16 | 1995-08-29 | James C. Chen | Method and apparatus for providing light-activated therapy |
US5368031A (en) | 1993-08-29 | 1994-11-29 | General Electric Company | Magnetic resonance surgery using heat waves produced with a laser fiber |
JP2616668B2 (en) | 1993-08-30 | 1997-06-04 | 日本電気株式会社 | Hermetically sealed structure of optical fiber introduction section |
FR2709763B1 (en) | 1993-09-08 | 1995-10-13 | Commissariat Energie Atomique | Device for processing a material, with miniaturized photo-ion head. |
US5496307A (en) | 1993-09-10 | 1996-03-05 | S.L.T. Japan Co., Ltd. | Laser light irradiation apparatus for medical treatment |
US5420768A (en) | 1993-09-13 | 1995-05-30 | Kennedy; John | Portable led photocuring device |
US6251100B1 (en) | 1993-09-24 | 2001-06-26 | Transmedica International, Inc. | Laser assisted topical anesthetic permeation |
US6635075B2 (en) | 1993-10-04 | 2003-10-21 | Huan-Chen Li | Method and apparatus for treatment of skin itch and disease |
US6245093B1 (en) | 1993-10-04 | 2001-06-12 | Huan-Chen Li | Method and apparatus for treatment of skin itch and disease |
US5415654A (en) * | 1993-10-05 | 1995-05-16 | S.L.T. Japan Co., Ltd. | Laser balloon catheter apparatus |
IL107248A0 (en) | 1993-10-11 | 1994-01-25 | Amcor Ltd | Apparatus for treatment of the oral cavity |
US5647866A (en) | 1993-11-09 | 1997-07-15 | Zaias; Nardo | Method of hair depilation |
US5498935A (en) | 1993-11-12 | 1996-03-12 | William H. McMahan | Laser flash lamp control system |
US5885211A (en) * | 1993-11-15 | 1999-03-23 | Spectrix, Inc. | Microporation of human skin for monitoring the concentration of an analyte |
US5458140A (en) | 1993-11-15 | 1995-10-17 | Non-Invasive Monitoring Company (Nimco) | Enhancement of transdermal monitoring applications with ultrasound and chemical enhancers |
US5445611A (en) | 1993-12-08 | 1995-08-29 | Non-Invasive Monitoring Company (Nimco) | Enhancement of transdermal delivery with ultrasound and chemical enhancers |
US5394492A (en) | 1993-11-19 | 1995-02-28 | Applied Optronics Corporation | High power semiconductor laser system |
US5413587A (en) * | 1993-11-22 | 1995-05-09 | Hochstein; Peter A. | Infrared heating apparatus and methods |
US20020019624A1 (en) | 1993-12-08 | 2002-02-14 | Clement Robert Marc | Depilation |
GB9325109D0 (en) | 1993-12-08 | 1994-02-09 | Sls Wales Ltd | Depilation |
US5628744A (en) | 1993-12-21 | 1997-05-13 | Laserscope | Treatment beam handpiece |
WO1995017924A1 (en) | 1993-12-30 | 1995-07-06 | The General Hospital Corporation | Apparatus and methods for laser-induced superficial alteration of a substrate |
US5558666A (en) | 1994-01-14 | 1996-09-24 | Coherent, Inc. | Handpiece for producing highly collimated laser beam for dermatological procedures |
US5358503A (en) | 1994-01-25 | 1994-10-25 | Bertwell Dale E | Photo-thermal therapeutic device and method |
US5386427A (en) * | 1994-02-10 | 1995-01-31 | Massachusetts Institute Of Technology | Thermally controlled lenses for lasers |
AT400305B (en) | 1994-03-07 | 1995-12-27 | Divida Ges M B H Methoden Und | Instrument for the treatment of skin zones |
JPH07249798A (en) | 1994-03-09 | 1995-09-26 | Fujitsu Ltd | Optical device securing apparatus and its manufacture |
IL108918A (en) * | 1994-03-10 | 1997-04-15 | Medic Lightech Ltd | Apparatus for efficient photodynamic treatment |
US5505726A (en) * | 1994-03-21 | 1996-04-09 | Dusa Pharmaceuticals, Inc. | Article of manufacture for the photodynamic therapy of dermal lesion |
US5616140A (en) * | 1994-03-21 | 1997-04-01 | Prescott; Marvin | Method and apparatus for therapeutic laser treatment |
US5561881A (en) | 1994-03-22 | 1996-10-08 | U.S. Philips Corporation | Electric toothbrush |
JP3530954B2 (en) * | 1994-03-24 | 2004-05-24 | 清之 竹迫 | Far-infrared sterilizer |
JP3263275B2 (en) * | 1994-04-05 | 2002-03-04 | ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア | Apparatus for laser treatment of living tissue and laser treatment apparatus for flame-like nevus |
US5979454A (en) * | 1995-05-15 | 1999-11-09 | The Regents Of The University Of California | Method and apparatus for causing rapid and deep spatially selective coagulation during thermally mediated therapeutic procedures |
US6248103B1 (en) | 1994-04-05 | 2001-06-19 | The Regents Of The University Of California | Apparatus and method for dynamic cooling of biological tissues for thermal mediated surgery using long laser pulses |
RU2089126C1 (en) | 1994-04-11 | 1997-09-10 | Учебно-научно-производственный "Лазерный центр" Института точной механики и оптики | Method of treatment of tooth hard tissues by laser radiation and device for its realization |
US5464436A (en) | 1994-04-28 | 1995-11-07 | Lasermedics, Inc. | Method of performing laser therapy |
AU2373695A (en) | 1994-05-03 | 1995-11-29 | Board Of Regents, The University Of Texas System | Apparatus and method for noninvasive doppler ultrasound-guided real-time control of tissue damage in thermal therapy |
FR2719470B1 (en) | 1994-05-04 | 1996-06-28 | Oreal | Method for bleaching hair by laser irradiation with cooling, and device for implementing it. |
US5519534A (en) * | 1994-05-25 | 1996-05-21 | The Government Of The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Irradiance attachment for an optical fiber to provide a uniform level of illumination across a plane |
JP3596029B2 (en) | 1994-06-06 | 2004-12-02 | 住友電気工業株式会社 | Semiconductor laser module |
US5422112A (en) | 1994-06-09 | 1995-06-06 | Chesebrough-Pond's Usa Co., Division Of Conopco, Inc. | Thickened cosmetic compositions |
US5652481A (en) | 1994-06-10 | 1997-07-29 | Beacon Light Products, Inc. | Automatic state tranition controller for a fluorescent lamp |
JPH07328025A (en) | 1994-06-14 | 1995-12-19 | Toshiba Corp | Medical laser device |
US6405732B1 (en) | 1994-06-24 | 2002-06-18 | Curon Medical, Inc. | Method to treat gastric reflux via the detection and ablation of gastro-esophageal nerves and receptors |
JPH0815539A (en) | 1994-06-30 | 1996-01-19 | Hoya Corp | Optical coupler |
US5586132A (en) | 1994-07-27 | 1996-12-17 | Laser Industries Ltd. | Method and apparatus for generating bright light sources |
US5810802A (en) | 1994-08-08 | 1998-09-22 | E.P. Technologies, Inc. | Systems and methods for controlling tissue ablation using multiple temperature sensing elements |
JPH0866781A (en) | 1994-08-30 | 1996-03-12 | Mitsubishi Electric Corp | Excimer laser beam irradiating device |
US5530711A (en) | 1994-09-01 | 1996-06-25 | The United States Of America As Represented By The Secretary Of The Navy | Low threshold diode-pumped tunable dye laser |
US5502582A (en) | 1994-09-02 | 1996-03-26 | Aavid Laboratories, Inc. | Light source cooler for LCD monitor |
US5531740A (en) | 1994-09-06 | 1996-07-02 | Rapistan Demag Corporation | Automatic color-activated scanning treatment of dermatological conditions by laser |
US5698866A (en) | 1994-09-19 | 1997-12-16 | Pdt Systems, Inc. | Uniform illuminator for phototherapy |
US5531739A (en) * | 1994-09-23 | 1996-07-02 | Coherent, Inc. | Method of treating veins |
US5522813A (en) * | 1994-09-23 | 1996-06-04 | Coherent, Inc. | Method of treating veins |
US5669916A (en) | 1994-09-28 | 1997-09-23 | The General Hospital Corporation | Method of hair removal |
US5662643A (en) | 1994-09-28 | 1997-09-02 | Abiomed R & D, Inc. | Laser welding system |
US5608210A (en) | 1994-09-29 | 1997-03-04 | Esparza; Joel | Infrared aided method and apparatus for venous examination |
US5595178A (en) | 1994-10-02 | 1997-01-21 | Hmt High Medical Technologies Gmbh | System, method and apparatus for treatment of degenerative bone |
US5735884A (en) * | 1994-10-04 | 1998-04-07 | Medtronic, Inc. | Filtered feedthrough assembly for implantable medical device |
US5746735A (en) | 1994-10-26 | 1998-05-05 | Cynosure, Inc. | Ultra long pulsed dye laser device for treatment of ectatic vessels and method therefor |
US5571098A (en) | 1994-11-01 | 1996-11-05 | The General Hospital Corporation | Laser surgical devices |
RU2089127C1 (en) | 1994-11-02 | 1997-09-10 | Григорий Борисович Альтшулер | Method of treatment of tooth hard tissues by laser radiation and device for its realization |
US5541948A (en) | 1994-11-28 | 1996-07-30 | The Regents Of The University Of California | Transition-metal doped sulfide, selenide, and telluride laser crystal and lasers |
AT403654B (en) | 1994-12-01 | 1998-04-27 | Binder Michael Dr | DEVICE FOR THE OPTICAL EXAMINATION OF HUMAN SKIN AND THE SAME ASSIGNMENT EVALUATION DEVICE |
EP0843577A1 (en) | 1994-12-09 | 1998-05-27 | Cynosure, Inc. | Near-infrared selective photothermolysis for vascular targets |
GB9514872D0 (en) | 1994-12-14 | 1995-09-20 | Brine Lee | Optical fibre laser delivery probe and use thereof |
US5558667A (en) | 1994-12-14 | 1996-09-24 | Coherent, Inc. | Method and apparatus for treating vascular lesions |
US5557625A (en) | 1995-01-05 | 1996-09-17 | Cynosure, Inc. | Coupled-cavity resonator to improve the intensity profile of a laser beam |
AT401342B (en) | 1995-01-17 | 1996-08-26 | Myles Handels Gmbh | SOFTLASER WITH INTEGRATED POINT DETECTOR FOR ACUPUNCTURE POINTS |
US5632741A (en) | 1995-01-20 | 1997-05-27 | Lucid Technologies, Inc. | Epilation system |
US5743902A (en) | 1995-01-23 | 1998-04-28 | Coherent, Inc. | Hand-held laser scanner |
US5599342A (en) | 1995-01-27 | 1997-02-04 | Candela Laser Corporation | Method for treating pigmentation abnormalities using pulsed laser radiation with an elongated cross-section and apparatus for providing same |
US5735844A (en) * | 1995-02-01 | 1998-04-07 | The General Hospital Corporation | Hair removal using optical pulses |
US5595568A (en) * | 1995-02-01 | 1997-01-21 | The General Hospital Corporation | Permanent hair removal using optical pulses |
US5598426A (en) * | 1995-02-03 | 1997-01-28 | Candela Laser Corporation | Method and dye laser apparatus for producing long pulses of laser radiation |
US5611795A (en) | 1995-02-03 | 1997-03-18 | Laser Industries, Ltd. | Laser facial rejuvenation |
US5643334A (en) | 1995-02-07 | 1997-07-01 | Esc Medical Systems Ltd. | Method and apparatus for the diagnostic and composite pulsed heating and photodynamic therapy treatment |
US5728090A (en) | 1995-02-09 | 1998-03-17 | Quantum Devices, Inc. | Apparatus for irradiating living cells |
US6409722B1 (en) | 1998-07-07 | 2002-06-25 | Medtronic, Inc. | Apparatus and method for creating, maintaining, and controlling a virtual electrode used for the ablation of tissue |
RU2096051C1 (en) | 1995-02-24 | 1997-11-20 | Григорий Борисович Альтшулер | Apparatus for laser treatment of biological tissues (alternative embodiments) |
US5868731A (en) | 1996-03-04 | 1999-02-09 | Innotech Usa, Inc. | Laser surgical device and method of its use |
WO1996028212A1 (en) | 1995-03-09 | 1996-09-19 | Innotech Usa, Inc. | Laser surgical device and method of its use |
US5885273A (en) * | 1995-03-29 | 1999-03-23 | Esc Medical Systems, Ltd. | Method for depilation using pulsed electromagnetic radiation |
WO1996031237A2 (en) | 1995-04-04 | 1996-10-10 | Wound Healing Of Oklahoma | Cancer treatment by photodynamic therapy, in combination with an immunoadjuvant |
RU2082337C1 (en) | 1995-04-10 | 1997-06-27 | Григорий Борисович Альтшулер | Tip piece of laser system for treating biological tissue |
CA2218374C (en) | 1995-04-17 | 2001-07-03 | W. Gregory Chernoff | Laser powered apparatus for affecting structures beneath the skin |
US5707369A (en) * | 1995-04-24 | 1998-01-13 | Ethicon Endo-Surgery, Inc. | Temperature feedback monitor for hemostatic surgical instrument |
US5658148A (en) | 1995-04-26 | 1997-08-19 | Ceramoptec Industries, Inc. | Dental laser brushing or cleaning device |
US6056548A (en) | 1995-04-26 | 2000-05-02 | Ceramoptec Industries, Inc. | Hygienic dental laser photo treatment method |
US5688267A (en) | 1995-05-01 | 1997-11-18 | Ep Technologies, Inc. | Systems and methods for sensing multiple temperature conditions during tissue ablation |
JPH08299310A (en) | 1995-05-02 | 1996-11-19 | Toa Medical Electronics Co Ltd | Non-invasive blood analysis device and method therefor |
US6425912B1 (en) | 1995-05-05 | 2002-07-30 | Thermage, Inc. | Method and apparatus for modifying skin surface and soft tissue structure |
US6241753B1 (en) * | 1995-05-05 | 2001-06-05 | Thermage, Inc. | Method for scar collagen formation and contraction |
US6430446B1 (en) | 1995-05-05 | 2002-08-06 | Thermage, Inc. | Apparatus for tissue remodeling |
US5660836A (en) | 1995-05-05 | 1997-08-26 | Knowlton; Edward W. | Method and apparatus for controlled contraction of collagen tissue |
DE29508077U1 (en) | 1995-05-16 | 1995-08-10 | Wilden Lutz Dr Med | Oral care device |
US5624435A (en) | 1995-06-05 | 1997-04-29 | Cynosure, Inc. | Ultra-long flashlamp-excited pulse dye laser for therapy and method therefor |
US6022346A (en) * | 1995-06-07 | 2000-02-08 | Ep Technologies, Inc. | Tissue heating and ablation systems and methods using self-heated electrodes |
DE19521003C1 (en) | 1995-06-08 | 1996-08-14 | Baasel Carl Lasertech | Pulsed light source for removing biological tissue |
JP3507204B2 (en) | 1995-06-29 | 2004-03-15 | キヤノン株式会社 | Ophthalmic equipment |
FR2736390B1 (en) * | 1995-07-05 | 1997-08-08 | Hispano Suiza Sa | PUSH INVERTER OF A SHELL TURBOREACTOR |
US5673451A (en) | 1995-07-06 | 1997-10-07 | Moore; James R. | Instructional toothbrush |
JP3592406B2 (en) | 1995-07-10 | 2004-11-24 | 富士通株式会社 | Optical module and method for manufacturing optical module |
US5879376A (en) | 1995-07-12 | 1999-03-09 | Luxar Corporation | Method and apparatus for dermatology treatment |
US5658323A (en) * | 1995-07-12 | 1997-08-19 | Miller; Iain D. | Method and apparatus for dermatology treatment |
US6263233B1 (en) | 1995-07-13 | 2001-07-17 | Lucid, Inc. | Handheld imaging microscope |
US6240306B1 (en) | 1995-08-09 | 2001-05-29 | Rio Grande Medical Technologies, Inc. | Method and apparatus for non-invasive blood analyte measurement with fluid compartment equilibration |
US6669685B1 (en) | 1997-11-06 | 2003-12-30 | Biolase Technology, Inc. | Tissue remover and method |
US7620290B2 (en) | 1995-08-31 | 2009-11-17 | Biolase Technology, Inc. | Modified-output fiber optic tips |
US5849029A (en) | 1995-12-26 | 1998-12-15 | Esc Medical Systems, Ltd. | Method for controlling the thermal profile of the skin |
US5546214A (en) | 1995-09-13 | 1996-08-13 | Reliant Technologies, Inc. | Method and apparatus for treating a surface with a scanning laser beam having an improved intensity cross-section |
US5964749A (en) | 1995-09-15 | 1999-10-12 | Esc Medical Systems Ltd. | Method and apparatus for skin rejuvenation and wrinkle smoothing |
JPH0984803A (en) | 1995-09-27 | 1997-03-31 | Terumo Corp | Laser treatment apparatus |
US5836999A (en) | 1995-09-28 | 1998-11-17 | Esc Medical Systems Ltd. | Method and apparatus for treating psoriasis using pulsed electromagnetic radiation |
US5776175A (en) | 1995-09-29 | 1998-07-07 | Esc Medical Systems Ltd. | Method and apparatus for treatment of cancer using pulsed electromagnetic radiation |
GB9520564D0 (en) | 1995-10-07 | 1995-12-13 | Philips Electronics Nv | Apparatus for treating a patient |
US5824023A (en) | 1995-10-12 | 1998-10-20 | The General Hospital Corporation | Radiation-delivery device |
US5916211A (en) | 1995-11-03 | 1999-06-29 | Quon; Hew W. | Permanent hair removal using visible red wavelength spectrum lasers |
US5921981A (en) | 1995-11-09 | 1999-07-13 | Alcon Laboratories, Inc. | Multi-spot laser surgery |
JPH09141869A (en) | 1995-11-24 | 1997-06-03 | Seiko Epson Corp | Ink-jet type recording apparatus |
US6083217A (en) | 1995-11-29 | 2000-07-04 | Lumedics, Ltd. | Destruction for unwanted tissue by deep laser heating of water |
US5897549A (en) | 1995-11-29 | 1999-04-27 | Lumedics, Ltd. | Transformation of unwanted tissue by deep laser heating of water |
US5837001A (en) | 1995-12-08 | 1998-11-17 | C. R. Bard | Radio frequency energy delivery system for multipolar electrode catheters |
US5713738A (en) | 1995-12-12 | 1998-02-03 | Britesmile, Inc. | Method for whitening teeth |
IL118229A0 (en) | 1996-05-12 | 1997-03-18 | Laser Ind Ltd | Apparatus and method for cutaneous treatment employing a laser |
US5879346A (en) | 1995-12-18 | 1999-03-09 | Esc Medical Systems, Ltd. | Hair removal by selective photothermolysis with an alexandrite laser |
US5651783A (en) | 1995-12-20 | 1997-07-29 | Reynard; Michael | Fiber optic sleeve for surgical instruments |
CA2166034A1 (en) | 1995-12-22 | 1997-06-23 | Chia-Yu Cheng | Skin brush massage method |
KR0155936B1 (en) | 1995-12-26 | 1998-12-15 | 손욱 | Fluorescent lamp ballast circuit |
US7006874B2 (en) | 1996-01-05 | 2006-02-28 | Thermage, Inc. | Treatment apparatus with electromagnetic energy delivery device and non-volatile memory |
US6350276B1 (en) * | 1996-01-05 | 2002-02-26 | Thermage, Inc. | Tissue remodeling apparatus containing cooling fluid |
GB9602375D0 (en) | 1996-02-06 | 1996-04-03 | Jones Gary L | Laser depilation apparatus and method |
US20070185552A1 (en) | 1996-02-13 | 2007-08-09 | Leonardo Masotti | Device and method for biological tissue stimulation by high intensity laser therapy |
JPH09218325A (en) | 1996-02-13 | 1997-08-19 | Mitsubishi Electric Corp | Semiconductor laser module |
IT1286551B1 (en) | 1996-02-13 | 1998-07-15 | El En S R L | DEVICE AND METHOD FOR THE ELIMINATION OF ADIPOSE LAYERS THROUGH LASER ENERGY |
JPH09220292A (en) | 1996-02-20 | 1997-08-26 | Minolta Co Ltd | Phototherapy equipment |
US5971976A (en) | 1996-02-20 | 1999-10-26 | Computer Motion, Inc. | Motion minimization and compensation system for use in surgical procedures |
US5835648A (en) | 1996-03-07 | 1998-11-10 | Miravant Systems, Inc. | Surface illuminator for photodynamic therapy |
US5818580A (en) | 1996-03-12 | 1998-10-06 | Rutgers, The State University | Simultaneous multisample analysis and apparatus therefor |
JP3662068B2 (en) | 1996-03-21 | 2005-06-22 | 飯村 惠次 | Photocatalyst device and cleaning device using photocatalyst |
US6239442B1 (en) | 1996-03-21 | 2001-05-29 | Keiji Iimura | Cleaning apparatus using ultraviolet rays |
US5630811A (en) * | 1996-03-25 | 1997-05-20 | Miller; Iain D. | Method and apparatus for hair removal |
AU2607197A (en) | 1996-04-09 | 1997-10-29 | Cynosure Corporation | Alexandrite laser system for treatment of dermatological specimens |
US5871479A (en) | 1996-11-07 | 1999-02-16 | Cynosure, Inc. | Alexandrite laser system for hair removal and method therefor |
US5843072A (en) | 1996-11-07 | 1998-12-01 | Cynosure, Inc. | Method for treatment of unwanted veins and device therefor |
WO1997037723A1 (en) | 1996-04-10 | 1997-10-16 | New Star Lasers, Inc. | Improved method and device for laser induced shrinking of collagen |
US5742392A (en) | 1996-04-16 | 1998-04-21 | Seymour Light, Inc. | Polarized material inspection apparatus |
US5944687A (en) | 1996-04-24 | 1999-08-31 | The Regents Of The University Of California | Opto-acoustic transducer for medical applications |
US5893828A (en) | 1996-05-02 | 1999-04-13 | Uram; Martin | Contact laser surgical endoscope and associated myringotomy procedure |
TW364841B (en) | 1996-05-14 | 1999-07-21 | Kao Corp | Toothbrush |
US5662644A (en) | 1996-05-14 | 1997-09-02 | Mdlt, Inc. | Dermatological laser apparatus and method |
US5655547A (en) * | 1996-05-15 | 1997-08-12 | Esc Medical Systems Ltd. | Method for laser surgery |
US5743901A (en) * | 1996-05-15 | 1998-04-28 | Star Medical Technologies, Inc. | High fluence diode laser device and method for the fabrication and use thereof |
US6013053A (en) | 1996-05-17 | 2000-01-11 | Qlt Photo Therapeutics Inc. | Balloon catheter for photodynamic therapy |
GB9611170D0 (en) | 1996-05-29 | 1996-07-31 | Sls Wales Ltd | Reduction of vascular blemishes by selective thermolysis |
GB9611180D0 (en) | 1996-05-29 | 1996-07-31 | Sls Wales Ltd | Treatment of vascular lesions |
US5776129A (en) | 1996-06-12 | 1998-07-07 | Ethicon Endo-Surgery, Inc. | Endometrial ablation apparatus and method |
US6183434B1 (en) | 1996-07-03 | 2001-02-06 | Spectrx, Inc. | Multiple mechanical microporation of skin or mucosa |
JPH1014661A (en) | 1996-07-09 | 1998-01-20 | Kinue Mogami | Electric toothbrush set |
KR100205052B1 (en) | 1996-07-12 | 1999-06-15 | 정선종 | Mode locking optical fiber laser of wavelength tunable type |
WO1998004184A2 (en) * | 1996-07-25 | 1998-02-05 | Light Medicine, Inc. | Photodynamic therapy apparatus and methods |
US6443974B1 (en) | 1996-07-28 | 2002-09-03 | Biosense, Inc. | Electromagnetic cardiac biostimulation |
US5814008A (en) | 1996-07-29 | 1998-09-29 | Light Sciences Limited Partnership | Method and device for applying hyperthermia to enhance drug perfusion and efficacy of subsequent light therapy |
US5976123A (en) * | 1996-07-30 | 1999-11-02 | Laser Aesthetics, Inc. | Heart stabilization |
US5820626A (en) | 1996-07-30 | 1998-10-13 | Laser Aesthetics, Inc. | Cooling laser handpiece with refillable coolant reservoir |
US5913883A (en) | 1996-08-06 | 1999-06-22 | Alexander; Dane | Therapeutic facial mask |
AU3825097A (en) | 1996-08-06 | 1998-02-25 | Edward W. Knowlton | Method for tightening skin |
WO1998006456A1 (en) | 1996-08-08 | 1998-02-19 | Light Sciences Limited Partnership | Method and apparatus to treat gingival and periodontal disease |
US6096029A (en) * | 1997-02-24 | 2000-08-01 | Laser Skin Toner, Inc. | Laser method for subsurface cutaneous treatment |
NO963546D0 (en) | 1996-08-23 | 1996-08-23 | Eric Larsen | Method of permanent hair removal using light |
GB9618051D0 (en) | 1996-08-29 | 1996-10-09 | Sls Wales Ltd | Wrinkle removal |
US5851181A (en) | 1996-08-30 | 1998-12-22 | Esc Medical Systems Ltd. | Apparatus for simultaneously viewing and spectrally analyzing a portion of skin |
US6214034B1 (en) | 1996-09-04 | 2001-04-10 | Radiancy, Inc. | Method of selective photothermolysis |
US5759200A (en) * | 1996-09-04 | 1998-06-02 | Azar; Zion | Method of selective photothermolysis |
US6364888B1 (en) | 1996-09-09 | 2002-04-02 | Intuitive Surgical, Inc. | Alignment of master and slave in a minimally invasive surgical apparatus |
AU7101396A (en) | 1996-09-10 | 1998-04-02 | Grigory Borisovich Altshuler | Toothbrush |
US5908418A (en) | 1996-09-13 | 1999-06-01 | Dority; Douglas B. | Hand held coagulating device |
JP3036232U (en) | 1996-09-26 | 1997-04-15 | ヤーマン株式会社 | Optical hair removal device |
US5782249A (en) * | 1996-09-30 | 1998-07-21 | Weber; Paul J. | Laser manicure process |
US6424852B1 (en) | 1996-10-18 | 2002-07-23 | Lucid, Inc. | System for confocal imaging within dermal tissue |
JP3365227B2 (en) | 1996-10-25 | 2003-01-08 | 花王株式会社 | Method and apparatus for measuring optical properties of skin surface condition |
US6338855B1 (en) * | 1996-10-25 | 2002-01-15 | The Procter & Gamble Company | Cleansing articles for skin and/or hair which also deposit skin care actives |
US7036516B1 (en) | 1996-10-30 | 2006-05-02 | Xantech Pharmaceuticals, Inc. | Treatment of pigmented tissues using optical energy |
US5893885A (en) | 1996-11-01 | 1999-04-13 | Cordis Webster, Inc. | Multi-electrode ablation catheter |
US6228075B1 (en) | 1996-11-07 | 2001-05-08 | Cynosure, Inc. | Alexandrite laser system for hair removal |
GB9623627D0 (en) | 1996-11-13 | 1997-01-08 | Meditech International Inc | Method and apparatus for photon therapy |
CN1073607C (en) | 1996-11-20 | 2001-10-24 | 中国科学院近代物理研究所 | Electronic radiation solidifying paint for building material surface |
US20060149343A1 (en) | 1996-12-02 | 2006-07-06 | Palomar Medical Technologies, Inc. | Cooling system for a photocosmetic device |
US6273884B1 (en) | 1997-05-15 | 2001-08-14 | Palomar Medical Technologies, Inc. | Method and apparatus for dermatology treatment |
US6517532B1 (en) | 1997-05-15 | 2003-02-11 | Palomar Medical Technologies, Inc. | Light energy delivery head |
US20080294152A1 (en) | 1996-12-02 | 2008-11-27 | Palomar Medical Technologies, Inc. | Cooling System For A Photocosmetic Device |
US6015404A (en) * | 1996-12-02 | 2000-01-18 | Palomar Medical Technologies, Inc. | Laser dermatology with feedback control |
US6653618B2 (en) * | 2000-04-28 | 2003-11-25 | Palomar Medical Technologies, Inc. | Contact detecting method and apparatus for an optical radiation handpiece |
US8182473B2 (en) | 1999-01-08 | 2012-05-22 | Palomar Medical Technologies | Cooling system for a photocosmetic device |
US7204832B2 (en) | 1996-12-02 | 2007-04-17 | Pálomar Medical Technologies, Inc. | Cooling system for a photo cosmetic device |
FR2756741B1 (en) | 1996-12-05 | 1999-01-08 | Cird Galderma | USE OF A CHROMOPHORE IN A COMPOSITION INTENDED TO BE APPLIED TO THE SKIN BEFORE LASER TREATMENT |
US6162211A (en) | 1996-12-05 | 2000-12-19 | Thermolase Corporation | Skin enhancement using laser light |
DE19654108C2 (en) | 1996-12-23 | 2001-10-04 | Massholder Karl F | Cleaning system and method for cleaning a surface |
US5879159A (en) | 1996-12-24 | 1999-03-09 | Ion Laser Technology, Inc. | Portable high power arc lamp system and applications therefor |
US5991697A (en) | 1996-12-31 | 1999-11-23 | The Regents Of The University Of California | Method and apparatus for optical Doppler tomographic imaging of fluid flow velocity in highly scattering media |
AU5623298A (en) | 1996-12-31 | 1998-07-31 | Altea Technologies, Inc. | Microporation of tissue for delivery of bioactive agents |
US6527716B1 (en) | 1997-12-30 | 2003-03-04 | Altea Technologies, Inc. | Microporation of tissue for delivery of bioactive agents |
US6063108A (en) | 1997-01-06 | 2000-05-16 | Salansky; Norman | Method and apparatus for localized low energy photon therapy (LEPT) |
US6391283B1 (en) | 1997-01-10 | 2002-05-21 | Ultradent Products, Inc. | Methods and apparatus for activating dental compositions |
US5830208A (en) * | 1997-01-31 | 1998-11-03 | Laserlite, Llc | Peltier cooled apparatus and methods for dermatological treatment |
US5810801A (en) | 1997-02-05 | 1998-09-22 | Candela Corporation | Method and apparatus for treating wrinkles in skin using radiation |
US5906609A (en) | 1997-02-05 | 1999-05-25 | Sahar Technologies | Method for delivering energy within continuous outline |
US5913833A (en) | 1997-02-07 | 1999-06-22 | Abbott Laboratories | Method and apparatus for obtaining biological fluids |
US6200309B1 (en) | 1997-02-13 | 2001-03-13 | Mcdonnell Douglas Corporation | Photodynamic therapy system and method using a phased array raman laser amplifier |
US5836877A (en) | 1997-02-24 | 1998-11-17 | Lucid Inc | System for facilitating pathological examination of a lesion in tissue |
US5974059A (en) | 1997-03-04 | 1999-10-26 | 3M Innovative Properties Company | Frequency doubled fiber laser |
DE19710676C2 (en) | 1997-03-16 | 1999-06-02 | Aesculap Meditec Gmbh | Arrangement for photoablation |
US6171302B1 (en) * | 1997-03-19 | 2001-01-09 | Gerard Talpalriu | Apparatus and method including a handpiece for synchronizing the pulsing of a light source |
AU6569198A (en) | 1997-03-19 | 1998-10-12 | Lucid Technologies, Inc. | Cellular surgery utilizing confocal microscopy |
US5891063A (en) * | 1997-04-03 | 1999-04-06 | Vigil; Arlene | Skin rejuvinating system |
DE29705934U1 (en) | 1997-04-03 | 1997-06-05 | Kaltenbach & Voigt | Diagnostic and treatment device for teeth |
DE19714475C1 (en) * | 1997-04-08 | 1998-12-17 | Wavelight Laser Technologie Gm | Unit for the removal of glass components from the eye |
FR2762504B1 (en) | 1997-04-29 | 1999-09-10 | Cird Galderma | HAIR REMOVAL PROCESS |
US6317624B1 (en) | 1997-05-05 | 2001-11-13 | The General Hospital Corporation | Apparatus and method for demarcating tumors |
US6235015B1 (en) | 1997-05-14 | 2001-05-22 | Applied Optronics Corporation | Method and apparatus for selective hair depilation using a scanned beam of light at 600 to 1000 nm |
US6028694A (en) * | 1997-05-22 | 2000-02-22 | Schmidt; Gregory W. | Illumination device using pulse width modulation of a LED |
GB9710562D0 (en) | 1997-05-23 | 1997-07-16 | Medical Laser Technologies Lim | Light delivery |
US6117129A (en) | 1997-05-30 | 2000-09-12 | Nidek Co., Ltd. | Laser treatment apparatus |
EP0880941B1 (en) | 1997-05-30 | 2001-12-19 | Nidek Co., Ltd. | Laser treatment apparatus |
US6030399A (en) | 1997-06-04 | 2000-02-29 | Spectrx, Inc. | Fluid jet blood sampling device and methods |
US20020018754A1 (en) | 1999-03-15 | 2002-02-14 | Paul Albert Sagel | Shapes for tooth whitening strips |
DE19724299C2 (en) | 1997-06-09 | 2003-03-27 | Sli Lichtsysteme Gmbh | Method and device for the cosmetic treatment of acne vulgaris |
EP0885629A3 (en) | 1997-06-16 | 1999-07-21 | Danish Dermatologic Development A/S | Light pulse generating apparatus and cosmetic and therapeutic phototreatment |
US6475211B2 (en) * | 1997-06-17 | 2002-11-05 | Cool Laser Optics, Inc. | Method and apparatus for temperature control of biologic tissue with simultaneous irradiation |
US5883471A (en) | 1997-06-20 | 1999-03-16 | Polycom, Inc. | Flashlamp pulse shaper and method |
AU8155098A (en) | 1997-06-20 | 1999-01-04 | Biolase Technology, Inc. | Electromagnetic radiation emitting toothbrush and dentifrice system |
US5885274A (en) * | 1997-06-24 | 1999-03-23 | New Star Lasers, Inc. | Filament lamp for dermatological treatment |
US5968034A (en) | 1997-06-24 | 1999-10-19 | Laser Aesthetics, Inc. | Pulsed filament lamp for dermatological treatment |
US5951543A (en) | 1997-06-30 | 1999-09-14 | Clinicon Corporation | Delivery system and method for surgical laser |
US6142650A (en) | 1997-07-10 | 2000-11-07 | Brown; David C. | Laser flashlight |
US6097741A (en) | 1998-02-17 | 2000-08-01 | Calmar Optcom, Inc. | Passively mode-locked fiber lasers |
US6058937A (en) | 1997-07-18 | 2000-05-09 | Miravant Systems, Inc. | Photodynamic Therapy of highly vascularized tissue |
US5921926A (en) | 1997-07-28 | 1999-07-13 | University Of Central Florida | Three dimensional optical imaging colposcopy |
US6104959A (en) * | 1997-07-31 | 2000-08-15 | Microwave Medical Corp. | Method and apparatus for treating subcutaneous histological features |
JP4014255B2 (en) | 1997-07-31 | 2007-11-28 | 有限会社開発顧問室 | Laser irradiation device for skin treatment |
US6273885B1 (en) * | 1997-08-16 | 2001-08-14 | Cooltouch Corporation | Handheld photoepilation device and method |
US6251127B1 (en) | 1997-08-25 | 2001-06-26 | Advanced Photodynamic Technologies, Inc. | Dye treatment solution and photodynamic therapy and method of using same |
CA2302044C (en) | 1997-08-25 | 2011-07-05 | Advanced Photodynamic Technologies, Inc. | Treatment device for topical photodynamic therapy and method of making same |
US6459919B1 (en) | 1997-08-26 | 2002-10-01 | Color Kinetics, Incorporated | Precision illumination methods and systems |
US6074382A (en) * | 1997-08-29 | 2000-06-13 | Asah Medico A/S | Apparatus for tissue treatment |
US6171300B1 (en) * | 1997-09-04 | 2001-01-09 | Linvatec Corporation | Tubing cassette and method for cooling a surgical handpiece |
US6233584B1 (en) | 1997-09-09 | 2001-05-15 | International Business Machines Corporation | Technique for providing a universal query for multiple different databases |
JP3019207B2 (en) | 1997-09-11 | 2000-03-13 | 川崎重工業株式会社 | Excavation equipment for shield machine |
US5813855A (en) | 1997-09-23 | 1998-09-29 | Crisio, Jr.; Raymond A. | Illuminated toothbrush |
US6176854B1 (en) | 1997-10-08 | 2001-01-23 | Robert Roy Cone | Percutaneous laser treatment |
US5984915A (en) | 1997-10-08 | 1999-11-16 | Trimedyne, Inc. | Percutaneous laser treatment |
EP1026999B1 (en) | 1997-10-08 | 2006-06-07 | The General Hospital Corporation | Phototherapy systems |
DE19841217B4 (en) | 1997-10-27 | 2005-06-16 | Applied Photonics Worldwide, Inc., Reno | Apparatus and method for the spectroscopic analysis of human or animal tissue or body fluids |
US6071239A (en) | 1997-10-27 | 2000-06-06 | Cribbs; Robert W. | Method and apparatus for lipolytic therapy using ultrasound energy |
US20010048077A1 (en) | 1997-10-27 | 2001-12-06 | Afanassieva Natalia I. | Apparatus and method for spectroscopic analysis of human or animal tissue or body fluids |
US6106516A (en) | 1997-10-30 | 2000-08-22 | Sonique Surgical Systems, Inc. | Laser-assisted liposuction method and apparatus |
US5968033A (en) * | 1997-11-03 | 1999-10-19 | Fuller Research Corporation | Optical delivery system and method for subsurface tissue irradiation |
DE19751867A1 (en) | 1997-11-22 | 1999-05-27 | Bosch Gmbh Robert | Tilt tendency detection in vehicle |
AU1613799A (en) | 1997-12-01 | 1999-06-16 | Esc Medical Systems Ltd. | Improved depilatory method and device |
US5935124A (en) | 1997-12-02 | 1999-08-10 | Cordis Webster, Inc. | Tip electrode with multiple temperature sensors |
AU1805399A (en) * | 1997-12-04 | 1999-06-16 | Thermolase Corporation | Skin cooling apparatus and method for laser assisted skin treatments |
GB2335603B (en) | 1997-12-05 | 2002-12-04 | Thermolase Corp | Skin enhancement using laser light |
US6229831B1 (en) | 1997-12-08 | 2001-05-08 | Coherent, Inc. | Bright diode-laser light-source |
US5949222A (en) | 1997-12-08 | 1999-09-07 | Buono; Robert N. | Self-oscillating switch mode DC to DC conversion with current switching threshold hystersis |
FR2772274B1 (en) * | 1997-12-16 | 2002-01-04 | Galderma Rech Dermatologique | DEVICE COMPRISING A CHROMOPHORE COMPOSITION FOR APPLICATION ON THE SKIN, METHOD FOR MANUFACTURING SUCH A DEVICE AND USES THEREOF |
US6007219A (en) | 1997-12-17 | 1999-12-28 | O'meara; James C. | Laser lighting system |
US6113559A (en) | 1997-12-29 | 2000-09-05 | Klopotek; Peter J. | Method and apparatus for therapeutic treatment of skin with ultrasound |
US6325769B1 (en) | 1998-12-29 | 2001-12-04 | Collapeutics, Llc | Method and apparatus for therapeutic treatment of skin |
IL122840A (en) | 1997-12-31 | 2002-04-21 | Radiancy Inc | Apparatus and methods for removing hair |
WO1999034868A1 (en) | 1998-01-07 | 1999-07-15 | Kim Robin Segal | Diode laser irradiation and electrotherapy system for biological tissue stimulation |
US6221068B1 (en) | 1998-01-15 | 2001-04-24 | Northwestern University | Method for welding tissue |
US6200134B1 (en) | 1998-01-20 | 2001-03-13 | Kerr Corporation | Apparatus and method for curing materials with radiation |
US7048731B2 (en) | 1998-01-23 | 2006-05-23 | Laser Abrasive Technologies, Llc | Methods and apparatus for light induced processing of biological tissues and of dental materials |
US6724958B1 (en) | 1998-01-23 | 2004-04-20 | Science & Engineering Associates, Inc. | Handheld laser system emitting visible non-visible radiation |
RU2175873C2 (en) | 1998-01-23 | 2001-11-20 | Альтшулер Григорий Борисович | Method and device for carrying out light-induced treatment of materials, mainly biological tissues |
CN1058905C (en) | 1998-01-25 | 2000-11-29 | 重庆海扶(Hifu)技术有限公司 | High-intensity focus supersonic tumor scanning therapy system |
US6165170A (en) | 1998-01-29 | 2000-12-26 | International Business Machines Corporation | Laser dermablator and dermablation |
ATE291787T1 (en) | 1998-01-29 | 2005-04-15 | Visx Inc | LASER LIGHT SOURCE WITH DIFFRACTIVE OPTICAL BEAM INTEGRATION |
DE19803460C1 (en) | 1998-01-30 | 1999-08-12 | Dornier Medizintechnik | Application device for the treatment of biological tissue with laser radiation |
US6074385A (en) | 1998-02-03 | 2000-06-13 | Kiefer Corp. | Hair follicle devitalization by induced heating of magnetically susceptible particles |
US20010016732A1 (en) | 1998-02-03 | 2001-08-23 | James L. Hobart | Dual mode laser delivery system providing controllable depth of tissue ablation and corresponding controllable depth of coagulation |
US6162055A (en) | 1998-02-13 | 2000-12-19 | Britesmile, Inc. | Light activated tooth whitening composition and method of using same |
US6416319B1 (en) | 1998-02-13 | 2002-07-09 | Britesmile, Inc. | Tooth whitening device and method of using same |
JP2908407B1 (en) | 1998-02-13 | 1999-06-21 | 甲府日本電気株式会社 | Multiprocessor device |
US6149895A (en) | 1998-02-17 | 2000-11-21 | Kreativ, Inc | Dental bleaching compositions, kits & methods |
US6149644A (en) | 1998-02-17 | 2000-11-21 | Altralight, Inc. | Method and apparatus for epidermal treatment with computer controlled moving focused infrared light |
IL123437A0 (en) | 1998-02-24 | 1998-09-24 | Shalev Pinchas | Apparatus and method for photothermal destruction of oral bacteria |
US6080146A (en) * | 1998-02-24 | 2000-06-27 | Altshuler; Gregory | Method and apparatus for hair removal |
US6029303A (en) | 1998-03-04 | 2000-02-29 | Dewan; Raman N. | Electronic toothbrush |
US6022316A (en) | 1998-03-06 | 2000-02-08 | Spectrx, Inc. | Apparatus and method for electroporation of microporated tissue for enhancing flux rates for monitoring and delivery applications |
WO1999044638A1 (en) | 1998-03-06 | 1999-09-10 | Spectrx, Inc. | Photothermal structure for biomedical applications, and method therefor |
US6530915B1 (en) | 1998-03-06 | 2003-03-11 | Spectrx, Inc. | Photothermal structure for biomedical applications, and method therefor |
US6173202B1 (en) * | 1998-03-06 | 2001-01-09 | Spectrx, Inc. | Method and apparatus for enhancing flux rates of a fluid in a microporated biological tissue |
EP1566149A1 (en) | 1998-03-12 | 2005-08-24 | Palomar Medical Technologies, Inc. | System for electromagnetic radiation of the skin |
US5920374A (en) | 1998-03-24 | 1999-07-06 | Board Of Trustees Of The University Of Arkansas | Computerized screening device utilizing the Pulfrich effect |
ES2403359T3 (en) | 1998-03-27 | 2013-05-17 | The General Hospital Corporation | Procedure and apparatus for the selective determination of lipid rich tissues |
EP0947173A1 (en) | 1998-03-30 | 1999-10-06 | Gabriel Bernaz | Probe for high frequency treatment of the skin |
US6306130B1 (en) | 1998-04-07 | 2001-10-23 | The General Hospital Corporation | Apparatus and methods for removing blood vessels |
US6264649B1 (en) | 1998-04-09 | 2001-07-24 | Ian Andrew Whitcroft | Laser treatment cooling head |
RU2145247C1 (en) | 1998-04-10 | 2000-02-10 | Жаров Владимир Павлович | Photomatrix therapeutic device for treatment of extended pathologies |
US6024095A (en) * | 1998-04-10 | 2000-02-15 | Proteus Therapeutics, Inc. | Corneal heat and stretch method and apparatus |
AU754594B2 (en) | 1998-04-24 | 2002-11-21 | Indigo Medical, Incorporated | Energy application system with ancillary information exchange capability, energy applicator, and methods associated therewith |
US6223071B1 (en) | 1998-05-01 | 2001-04-24 | Dusa Pharmaceuticals Inc. | Illuminator for photodynamic therapy and diagnosis which produces substantially uniform intensity visible light |
US6511492B1 (en) * | 1998-05-01 | 2003-01-28 | Microvention, Inc. | Embolectomy catheters and methods for treating stroke and other small vessel thromboembolic disorders |
US6099521A (en) | 1998-05-26 | 2000-08-08 | Shadduck; John H. | Semiconductor contact lens cooling system and technique for light-mediated eye therapies |
US5974616A (en) | 1998-05-26 | 1999-11-02 | Dreyfus; Edward | Sound producing toothbrush |
US6030378A (en) | 1998-05-26 | 2000-02-29 | Stewart; Bob W. | Method of hair removal by transcutaneous application of laser light |
US6203540B1 (en) | 1998-05-28 | 2001-03-20 | Pearl I, Llc | Ultrasound and laser face-lift and bulbous lysing device |
US6110195A (en) | 1998-06-01 | 2000-08-29 | Altralight, Inc. | Method and apparatus for surgical and dermatological treatment by multi-wavelength laser light |
AU4545899A (en) | 1998-06-03 | 1999-12-20 | Robert O. Wolf | System for whitening teeth surfaces |
US7216055B1 (en) | 1998-06-05 | 2007-05-08 | Crossbow Technology, Inc. | Dynamic attitude measurement method and apparatus |
US6029304A (en) | 1998-06-09 | 2000-02-29 | Colgate-Palmolive Company | Light interactive toothbrush |
US6080147A (en) | 1998-06-10 | 2000-06-27 | Tobinick; Edward L. | Method of employing a flashlamp for removal of hair, veins and capillaries |
US6077294A (en) | 1998-06-11 | 2000-06-20 | Cynosure, Inc. | Method for non-invasive wrinkle removal and skin treatment |
DE19827417B4 (en) | 1998-06-19 | 2004-10-28 | Hahn, Rainer, Dr.Med.Dent. | Material for different modification of the optical properties of different cells |
US6319274B1 (en) | 1998-06-22 | 2001-11-20 | John H. Shadduck | Devices and techniques for light-mediated stimulation of trabecular meshwork in glaucoma therapy |
US6416531B2 (en) | 1998-06-24 | 2002-07-09 | Light Sciences Corporation | Application of light at plural treatment sites within a tumor to increase the efficacy of light therapy |
US6447504B1 (en) | 1998-07-02 | 2002-09-10 | Biosense, Inc. | System for treatment of heart tissue using viability map |
ATE428345T1 (en) | 1998-07-09 | 2009-05-15 | Curelight Medical Ltd | DEVICE AND METHOD FOR EFFECTIVE HIGH-ENERGY PHOTODYNAMIC THERAPY OF ACNE VULGARIS AND SEBORRHEA |
WO2000003257A1 (en) | 1998-07-13 | 2000-01-20 | Sigma Systems Corporation | Thermal platform and method |
US5941701A (en) | 1998-07-14 | 1999-08-24 | Ceramoptec Ind Inc | Device and method to treat oral disease in felines |
JP2000037400A (en) | 1998-07-23 | 2000-02-08 | Nippon Sekigaisen Kogyo Kk | Front surface cooling method at the time of laser irradiation |
US6112123A (en) | 1998-07-28 | 2000-08-29 | Endonetics, Inc. | Device and method for ablation of tissue |
US6322584B2 (en) | 1998-07-31 | 2001-11-27 | Surx, Inc. | Temperature sensing devices and methods to shrink tissues |
US6236891B1 (en) | 1998-07-31 | 2001-05-22 | Surx, Inc. | Limited heat transfer devices and methods to shrink tissues |
GB9816914D0 (en) | 1998-08-05 | 1998-09-30 | Smithkline Beecham Gmbh | Novel device |
US6126655A (en) | 1998-08-11 | 2000-10-03 | The General Hospital Corporation | Apparatus and method for selective laser-induced heating of biological tissue |
DE19836649C2 (en) | 1998-08-13 | 2002-12-19 | Zeiss Carl Meditec Ag | Medical handpiece |
US6440155B1 (en) | 1998-08-19 | 2002-08-27 | Tokai University Educational System | Device for heating a biotissue employing a strong light |
US6101207A (en) | 1998-08-25 | 2000-08-08 | Ilorinne; Toni | Dye laser |
US6525819B1 (en) | 1998-09-02 | 2003-02-25 | Pocketspec Technologies Inc. | Colorimeter for dental applications |
US6282442B1 (en) | 1998-09-11 | 2001-08-28 | Surgical Laser Technologies, Inc. | Multi-fit suction irrigation hand piece |
JP3390755B2 (en) | 1998-09-29 | 2003-03-31 | 科学技術振興事業団 | Wavelength tunable short pulse light generating apparatus and method |
AU1442500A (en) | 1998-10-05 | 2000-04-26 | Scimed Life Systems, Inc. | Large area thermal ablation |
US6228074B1 (en) | 1998-10-15 | 2001-05-08 | Stephen Almeida | Multiple pulse photo-epilator |
US6595986B2 (en) | 1998-10-15 | 2003-07-22 | Stephen Almeida | Multiple pulse photo-dermatological device |
US6059820A (en) * | 1998-10-16 | 2000-05-09 | Paradigm Medical Corporation | Tissue cooling rod for laser surgery |
US6438396B1 (en) | 1998-11-05 | 2002-08-20 | Cytometrics, Inc. | Method and apparatus for providing high contrast imaging |
DE19852948C2 (en) * | 1998-11-12 | 2002-07-18 | Asclepion Meditec Ag | Dermatological handpiece |
KR100280821B1 (en) | 1998-11-18 | 2001-03-02 | 정선종 | Tunable Fiber Laser |
MY131835A (en) | 1998-11-20 | 2007-09-28 | Gen Hospital Corp | Permanent, removable tissue markings |
JP2000153003A (en) | 1998-11-24 | 2000-06-06 | Ya Man Ltd | Cooling probe for laser beauty culture instrument |
CZ287832B6 (en) | 1998-11-24 | 2001-02-14 | I.B.C., A. S. | Device for light therapy |
US6096209A (en) * | 1998-11-25 | 2000-08-01 | Aws Industries, L.L.C. | Three media silver recovery apparatus |
WO2000036715A1 (en) | 1998-11-25 | 2000-06-22 | The University Of New Mexico | Precisely wavelength-tunable and wavelength-switchable narrow linewidth lasers |
US6283956B1 (en) | 1998-11-30 | 2001-09-04 | David H. McDaniels | Reduction, elimination, or stimulation of hair growth |
US6936044B2 (en) * | 1998-11-30 | 2005-08-30 | Light Bioscience, Llc | Method and apparatus for the stimulation of hair growth |
US6663659B2 (en) * | 2000-01-13 | 2003-12-16 | Mcdaniel David H. | Method and apparatus for the photomodulation of living cells |
US6887260B1 (en) | 1998-11-30 | 2005-05-03 | Light Bioscience, Llc | Method and apparatus for acne treatment |
US6514242B1 (en) * | 1998-12-03 | 2003-02-04 | David Vasily | Method and apparatus for laser removal of hair |
US6183500B1 (en) | 1998-12-03 | 2001-02-06 | Sli Lichtsysteme Gmbh | Process and apparatus for the cosmetic treatment of acne vulgaris |
US6106293A (en) | 1998-12-04 | 2000-08-22 | Wiesel; Peter E. | Methods for whitening teeth |
US6402739B1 (en) * | 1998-12-08 | 2002-06-11 | Y-Beam Technologies, Inc. | Energy application with cooling |
US6493608B1 (en) | 1999-04-07 | 2002-12-10 | Intuitive Surgical, Inc. | Aspects of a control system of a minimally invasive surgical apparatus |
US6162215A (en) | 1998-12-23 | 2000-12-19 | Feng; Yuan Feng | Cauterization treatment by infrared rays |
US6164837A (en) | 1998-12-30 | 2000-12-26 | Mcdonnell Douglas Corporation | Integrated microelectromechanical alignment and locking apparatus and method for fiber optic module manufacturing |
US6183773B1 (en) | 1999-01-04 | 2001-02-06 | The General Hospital Corporation | Targeting of sebaceous follicles as a treatment of sebaceous gland disorders |
US6370180B2 (en) | 1999-01-08 | 2002-04-09 | Corning Incorporated | Semiconductor-solid state laser optical waveguide pump |
US6220772B1 (en) | 1999-01-13 | 2001-04-24 | Optiva Corporation | Fluid-dispensing and refilling system for a power toothbrush |
SE522249C2 (en) | 1999-01-13 | 2004-01-27 | Biolight Patent Holding Ab | Control device for controlling external processing by light |
US6402410B1 (en) | 1999-01-13 | 2002-06-11 | Philips Oral Healthcare | Fluid-dispensing and refilling system for a power toothbrush |
US6692517B2 (en) * | 1999-01-15 | 2004-02-17 | Cynosure, Inc. | Optical radiation treatment for enhancement of wound healing |
US6210426B1 (en) | 1999-01-15 | 2001-04-03 | Cynosure Inc | Optical radiation treatment for prevention of surgical scars |
SE515992C2 (en) | 1999-01-20 | 2001-11-05 | Biolight Patent Holding Ab | Light emitting organs for medical treatment are externalized by light |
AU2091100A (en) | 1999-01-25 | 2000-08-07 | Jilin Zhu | The optical quantum medical technology and the instrument thereof |
US6159236A (en) | 1999-01-28 | 2000-12-12 | Advanced Photodynamic Technologies, Inc. | Expandable treatment device for photodynamic therapy and method of using same |
US6202242B1 (en) | 1999-01-29 | 2001-03-20 | Zephyr Design, Inc. | Light emitting electric toothbrush |
WO2000044294A1 (en) | 1999-01-29 | 2000-08-03 | Welch Allyn, Inc. | Apparatus and method of photo-specific tissue treatment |
USD424197S (en) | 1999-02-12 | 2000-05-02 | Thermolase Corporation | Laser handpiece housing |
US6332891B1 (en) | 1999-02-16 | 2001-12-25 | Stryker Corporation | System and method for performing image guided surgery |
CA2362332A1 (en) | 1999-02-19 | 2000-08-24 | Scimed Life Systems, Inc. | Laser lithotripsy device with suction |
US20020090725A1 (en) | 2000-11-17 | 2002-07-11 | Simpson David G. | Electroprocessed collagen |
US6187029B1 (en) | 1999-03-02 | 2001-02-13 | Physician's Technology, Llc | Photo-thermal treatment device |
US6491685B2 (en) | 1999-03-04 | 2002-12-10 | The Regents Of The University Of California | Laser and acoustic lens for lithotripsy |
GB9905173D0 (en) | 1999-03-05 | 1999-04-28 | Sls Biophile Limited | Wrinkle reduction |
AU3147200A (en) * | 1999-03-08 | 2000-09-28 | Asah Medico A/S | An apparatus for tissue treatment and having a monitor for display of tissue features |
ATE298536T1 (en) | 1999-03-09 | 2005-07-15 | Thermage Inc | DEVICE FOR TREATING TISSUE |
JP3188426B2 (en) | 1999-03-12 | 2001-07-16 | ヤーマン株式会社 | Laser irradiation probe |
US6383176B1 (en) | 1999-03-15 | 2002-05-07 | Altus Medical, Inc. | Hair removal device and method |
US7041094B2 (en) | 1999-03-15 | 2006-05-09 | Cutera, Inc. | Tissue treatment device and method |
US6569155B1 (en) | 1999-03-15 | 2003-05-27 | Altus Medical, Inc. | Radiation delivery module and dermal tissue treatment method |
US6106294A (en) | 1999-03-15 | 2000-08-22 | Daniel; Martin K. | Lighting toothbrush and method of use |
US6235016B1 (en) * | 1999-03-16 | 2001-05-22 | Bob W. Stewart | Method of reducing sebum production by application of pulsed light |
RU2181571C2 (en) | 1999-03-18 | 2002-04-27 | Закрытое акционерное общество "LC" | Device and method for performing therapeutic and cosmetic phototreatment of biological tissue |
US6312451B1 (en) * | 1999-03-23 | 2001-11-06 | Jackson Streeter | Low level laser therapy apparatus |
US6240925B1 (en) | 1999-03-23 | 2001-06-05 | Cynosure, Inc. | Photothermal vascular targeting with bioreductive agents |
DE19914108A1 (en) | 1999-03-23 | 2000-10-05 | Plasmaphotonics Gmbh | Irradiation arrangement, in particular for optical thermolysis |
US6267779B1 (en) | 1999-03-29 | 2001-07-31 | Medelaser, Llc | Method and apparatus for therapeutic laser treatment |
US6484052B1 (en) | 1999-03-30 | 2002-11-19 | The Regents Of The University Of California | Optically generated ultrasound for enhanced drug delivery |
US6409723B1 (en) | 1999-04-02 | 2002-06-25 | Stuart D. Edwards | Treating body tissue by applying energy and substances |
JP4084903B2 (en) | 1999-04-14 | 2008-04-30 | 株式会社オプトン | Far infrared heating device |
WO2000062700A1 (en) | 1999-04-14 | 2000-10-26 | Koninklijke Philips Electronics N.V. | Hair-removing device with a controllable laser source |
US6709269B1 (en) | 2000-04-14 | 2004-03-23 | Gregory B. Altshuler | Apparatus and method for the processing of solid materials, including hard tissues |
US6162212A (en) | 1999-04-19 | 2000-12-19 | Esc Medical Systems, Ltd. | Optimal procedure for performing a hair removal |
JP2000300684A (en) | 1999-04-20 | 2000-10-31 | Nidek Co Ltd | Laser therapeutic equipment |
WO2000064537A1 (en) | 1999-04-27 | 2000-11-02 | The General Hospital Corporation Doing Business As Massachusetts General Hospital | Phototherapy method for treatment of acne |
US6497701B2 (en) | 1999-04-30 | 2002-12-24 | Visx, Incorporated | Method and system for ablating surfaces with partially overlapping craters having consistent curvature |
US6439888B1 (en) | 1999-05-03 | 2002-08-27 | Pls Liquidating Llc | Optical source and method |
RU2182025C2 (en) | 1999-05-05 | 2002-05-10 | Миржалил Хамитович Усманов | Fire-proofing device |
US20050279949A1 (en) | 1999-05-17 | 2005-12-22 | Applera Corporation | Temperature control for light-emitting diode stabilization |
DE19923427A1 (en) | 1999-05-21 | 2000-11-23 | Lohmann Therapie Syst Lts | Device for improved delivery of active agents to skin, useful e.g. for administering opiates, contains agent that increases local skin temperature or blood flow |
US6606755B1 (en) | 1999-05-24 | 2003-08-19 | American Applied Technology | Electronically timed toothbrush system |
WO2000071045A1 (en) | 1999-05-25 | 2000-11-30 | International Technologies (Lasers), Ltd. | Laser for skin treatment |
US7363071B2 (en) | 1999-05-26 | 2008-04-22 | Endocare, Inc. | Computer guided ablation of tissue using integrated ablative/temperature sensing devices |
EP1057454A3 (en) | 1999-05-31 | 2003-11-12 | Nidek Co., Ltd. | Laser skin treatment apparatus |
US6733492B2 (en) | 1999-05-31 | 2004-05-11 | Nidek Co., Ltd. | Laser treatment apparatus |
CA2310550A1 (en) | 1999-06-04 | 2000-12-04 | Eclipse Surgical Technologies, Inc. | Enhanced surgical device tracking system |
GB9912998D0 (en) | 1999-06-04 | 1999-08-04 | Sls Biophile Limited | Depilation |
US7371408B1 (en) | 1999-06-07 | 2008-05-13 | Wright Medical Technology, Inc. | Bone graft substitute composition |
AU780752B2 (en) | 1999-06-08 | 2005-04-14 | Nitto Denko Corporation | Apparatus for microporation of biological membranes using thin film tissue interface devices, and method therefor |
US6685699B1 (en) | 1999-06-09 | 2004-02-03 | Spectrx, Inc. | Self-removing energy absorbing structure for thermal tissue ablation |
EP1182982A1 (en) | 1999-06-09 | 2002-03-06 | Spectrx, Inc. | Self-removing energy absorbing structure for thermal tissue ablation |
EP1187572A1 (en) | 1999-06-18 | 2002-03-20 | Spectrx, Inc. | Light beam generation and focusing device |
JP2001000560A (en) | 1999-06-23 | 2001-01-09 | Ya Man Ltd | Laser beam radiation probe |
US7500956B1 (en) | 1999-06-29 | 2009-03-10 | Wilk Peter J | Apparatus and method for resonant destruction of tumors |
AU5908000A (en) | 1999-07-02 | 2001-01-22 | Hypermed Imaging, Inc. | Imaging apparatus with means for fusing thermal and hyperspectral images |
DE60002336T2 (en) | 1999-07-02 | 2004-03-04 | Asah Medico A/S | LASER CRYSTAL DEVICE |
US20020128695A1 (en) | 1999-07-07 | 2002-09-12 | Yoram Harth | Apparatus and method for high energy photodynamic therapy of acne vulgaris and seborrhea |
US20030216795A1 (en) | 1999-07-07 | 2003-11-20 | Yoram Harth | Apparatus and method for high energy photodynamic therapy of acne vulgaris, seborrhea and other skin disorders |
US20040122492A1 (en) | 1999-07-07 | 2004-06-24 | Yoram Harth | Phototherapeutic treatment of skin conditions |
US6210425B1 (en) | 1999-07-08 | 2001-04-03 | Light Sciences Corporation | Combined imaging and PDT delivery system |
JP3340090B2 (en) | 1999-07-19 | 2002-10-28 | ヤーマン株式会社 | Laser hair removal probe |
US20040111031A1 (en) | 1999-07-22 | 2004-06-10 | Alfano Robert R. | Spectral polarizing tomographic dermatoscope |
US6451007B1 (en) * | 1999-07-29 | 2002-09-17 | Dale E. Koop | Thermal quenching of tissue |
US6413267B1 (en) | 1999-08-09 | 2002-07-02 | Theralase, Inc. | Therapeutic laser device and method including noninvasive subsurface monitoring and controlling means |
US20030078499A1 (en) | 1999-08-12 | 2003-04-24 | Eppstein Jonathan A. | Microporation of tissue for delivery of bioactive agents |
US6290713B1 (en) | 1999-08-24 | 2001-09-18 | Thomas A. Russell | Flexible illuminators for phototherapy |
DE19944401A1 (en) | 1999-09-16 | 2001-03-22 | Laser & Med Tech Gmbh | Depth/structure-selective biological tissue treatment method and device e.g. for body hair removal, uses simultaneous application of pressure and irradiation with light |
DE19945416C1 (en) | 1999-09-22 | 2001-04-26 | Siemens Ag | Cooling arrangement for X-ray emitter for computer tomograph enables the X-ray source to be operated over longer periods |
US6529540B1 (en) | 1999-09-22 | 2003-03-04 | Photonics Research Ontario | Variable output coupling laser |
US6331111B1 (en) | 1999-09-24 | 2001-12-18 | Cao Group, Inc. | Curing light system useful for curing light activated composite materials |
GB2356570A (en) | 1999-09-30 | 2001-05-30 | Oe Lys Ltd | Acne treating apparatus based on the emission of light in three different ranges of wavelength |
US6406474B1 (en) | 1999-09-30 | 2002-06-18 | Ceramoptec Ind Inc | Device and method for application of radiation |
US7280866B1 (en) | 1999-10-06 | 2007-10-09 | National Research Council Of Canada | Non-invasive screening of skin diseases by visible/near-infrared spectroscopy |
US6758845B1 (en) | 1999-10-08 | 2004-07-06 | Lumenis Inc. | Automatic firing apparatus and methods for laser skin treatment over large areas |
US6355054B1 (en) | 1999-11-05 | 2002-03-12 | Ceramoptec Industries, Inc. | Laser system for improved transbarrier therapeutic radiation delivery |
US6358242B1 (en) | 1999-11-12 | 2002-03-19 | Ceramoptec Industries, Inc. | Post laser treatment for permanent hair removal |
US6530916B1 (en) | 1999-11-15 | 2003-03-11 | Visx, Incorporated | Uniform large area ablation system and method |
WO2001035846A1 (en) | 1999-11-16 | 2001-05-25 | Ganz Robert A | System and method of treating abnormal tissue in the human esophagus |
DE19954710C1 (en) | 1999-11-17 | 2001-03-15 | Pulsion Medical Sys Ag | Apparatus for treatment of blood vessels especially in eye, comprises laser to deliver structured beam and monitor system to measure concentration of chromophoric agents for system control |
JP2001145520A (en) | 1999-11-19 | 2001-05-29 | Sharion Kk | Far infrared rays mask |
US6527764B1 (en) | 1999-12-02 | 2003-03-04 | Ceramoptec Industries, Inc. | Device and method for laser biomodulation in PDT/surgery |
US6364872B1 (en) | 1999-12-06 | 2002-04-02 | Candela Corporation | Multipulse dye laser |
JP3188437B2 (en) | 1999-12-08 | 2001-07-16 | ヤーマン株式会社 | Laser irradiation probe |
US6638238B1 (en) | 1999-12-09 | 2003-10-28 | The Regents Of The University Of California | Liposuction cannula device and method |
US6743222B2 (en) | 1999-12-10 | 2004-06-01 | Candela Corporation | Method of treating disorders associated with sebaceous follicles |
DE19959508A1 (en) | 1999-12-10 | 2001-06-13 | Schaeffler Waelzlager Ohg | Guide rail for a linear bearing |
US6354370B1 (en) * | 1999-12-16 | 2002-03-12 | The United States Of America As Represented By The Secretary Of The Air Force | Liquid spray phase-change cooling of laser devices |
WO2001049194A2 (en) | 1999-12-30 | 2001-07-12 | Pearl Technology Holdings, Llc | Face-lifting device |
CO5271709A1 (en) | 2000-01-12 | 2003-04-30 | Pfizer Prod Inc | COMPOSITIONS AND PROCEDURES FOR THE AND TREATMENT OF AFFECTIONS RESPONDING TO STROGENS |
JP2001196665A (en) | 2000-01-13 | 2001-07-19 | Hamamatsu Kagaku Gijutsu Kenkyu Shinkokai | Two wavelength laser machining optical apparatus and laser machining method |
US6595934B1 (en) | 2000-01-19 | 2003-07-22 | Medtronic Xomed, Inc. | Methods of skin rejuvenation using high intensity focused ultrasound to form an ablated tissue area containing a plurality of lesions |
US6669688B2 (en) * | 2000-01-25 | 2003-12-30 | The Regents Of The University Of California | Method and apparatus for measuring the heat transfer coefficient during cryogen spray cooling of tissue |
IL150604A0 (en) | 2000-01-25 | 2003-02-12 | Palomar Medical Tech Inc | Method and apparatus for medical treatment utilizing long duration electromagnetic radiation |
US7860554B2 (en) | 2000-01-27 | 2010-12-28 | National Research Council Of Canada | Visible-near infrared spectroscopy in burn injury assessment |
AU2001239835A1 (en) | 2000-02-26 | 2001-09-03 | Advanced Photodynamic Technologies, Inc. | Photodynamic cellular and acellular organism eradication utilizing a photosensitive material and surfactant |
US6261595B1 (en) * | 2000-02-29 | 2001-07-17 | Zars, Inc. | Transdermal drug patch with attached pocket for controlled heating device |
JP2001238968A (en) | 2000-03-01 | 2001-09-04 | Ya Man Ltd | Laser beam irradiation probe |
US6464693B1 (en) | 2000-03-06 | 2002-10-15 | Plc Medical Systems, Inc. | Myocardial revascularization |
US7320593B2 (en) | 2000-03-08 | 2008-01-22 | Tir Systems Ltd. | Light emitting diode light source for curing dental composites |
US6436094B1 (en) | 2000-03-16 | 2002-08-20 | Laserscope, Inc. | Electromagnetic and laser treatment and cooling device |
GB2370992B (en) | 2000-03-23 | 2002-11-20 | Photo Therapeutics Ltd | Therapeutic light source and method |
US6749623B1 (en) | 2000-03-31 | 2004-06-15 | Richard A Hsi | Method and apparatus for catheter phototherapy with dose sensing |
GB2360946B (en) | 2000-04-08 | 2002-06-12 | Lynton Lasers Ltd | Dermatological treatment apparatus |
GB2361430A (en) | 2000-04-17 | 2001-10-24 | Photo Therapeutics Ltd | Therapeutic discharge lamps |
AU2001257069A1 (en) | 2000-04-17 | 2001-10-30 | Medelaser, Llc | Photostimulaton treatment apparatus and methods for use |
AU2001253654A1 (en) | 2000-04-27 | 2001-11-12 | Medtronic, Inc. | Vibration sensitive ablation apparatus and method |
US6554439B1 (en) | 2000-05-15 | 2003-04-29 | The Mclean Hospital | Illumination apparatus for simulating dynamic light conditions |
US6551346B2 (en) | 2000-05-17 | 2003-04-22 | Kent Crossley | Method and apparatus to prevent infections |
US9820883B2 (en) * | 2000-05-19 | 2017-11-21 | Michael S. Berlin | Method for treating glaucoma |
JP2001343560A (en) | 2000-05-30 | 2001-12-14 | Kyocera Corp | Optical module |
US6409665B1 (en) | 2000-06-01 | 2002-06-25 | Corey D. Scott | Apparatus for applying impedence matching fluid for ultrasonic imaging |
US6503269B2 (en) * | 2000-06-12 | 2003-01-07 | Scott A. Nield | Method of treating intervertebral discs using optical energy and optical temperature feedback |
JP2002011106A (en) | 2000-06-28 | 2002-01-15 | Nidek Co Ltd | Laser therapeutic apparatus |
US6652459B2 (en) | 2000-06-28 | 2003-11-25 | Peter Alfred Payne | Ophthalmic uses of lasers |
US6613040B2 (en) * | 2000-06-30 | 2003-09-02 | Nikolai Tankovich | Twin light laser |
US6544257B2 (en) | 2000-07-03 | 2003-04-08 | Olympus Optical Co., Ltd. | Thermal treatment apparatus |
GB2364376A (en) | 2000-07-05 | 2002-01-23 | Astron Clinica Ltd | Skin illumination and examination apparatus |
DE10033256A1 (en) | 2000-07-10 | 2002-01-24 | Coronet Werke Gmbh | Method and device for producing bristle goods and bristle goods |
US6471716B1 (en) | 2000-07-11 | 2002-10-29 | Joseph P. Pecukonis | Low level light therapy method and apparatus with improved wavelength, temperature and voltage control |
JP3868724B2 (en) * | 2000-07-18 | 2007-01-17 | 独立行政法人科学技術振興機構 | Ultrasound angioscope system |
EP1341464A4 (en) * | 2000-07-21 | 2009-07-22 | Ceramoptec Gmbh | Treatment for epithelial diseases |
US6454790B1 (en) | 2000-07-21 | 2002-09-24 | Ceramoptec Industries, Inc. | Treatment for Barrett's syndrome |
US6905492B2 (en) | 2000-07-31 | 2005-06-14 | Galil Medical Ltd. | Planning and facilitation systems and methods for cryosurgery |
AU2000264703A1 (en) | 2000-07-31 | 2002-02-13 | El. En. S.P.A. | Method and device for epilation by ultrasound |
IT1316597B1 (en) * | 2000-08-02 | 2003-04-24 | Actis S R L | OPTOACOUSTIC ULTRASONIC GENERATOR FROM LASER ENERGY POWERED THROUGH OPTICAL FIBER. |
US8565860B2 (en) | 2000-08-21 | 2013-10-22 | Biosensors International Group, Ltd. | Radioactive emission detector equipped with a position tracking system |
DE20014735U1 (en) | 2000-08-25 | 2000-10-12 | B & P Ag Roschacherberg | Light therapy device |
US6602275B1 (en) | 2000-09-18 | 2003-08-05 | Jana Sullivan | Device and method for therapeutic treatment of living organisms |
US6702808B1 (en) | 2000-09-28 | 2004-03-09 | Syneron Medical Ltd. | Device and method for treating skin |
US6471712B2 (en) | 2000-10-05 | 2002-10-29 | Steven A. Burres | Dermabrasion and skin care apparatus |
US6435873B1 (en) | 2000-10-10 | 2002-08-20 | 3M Innovative Properties Company | Medication delivery devices |
GB2368020A (en) | 2000-10-18 | 2002-04-24 | Icn Photonics Ltd | Treatment of acne vulgaris skin condition by irradiation with light of specific wavelengths to target specific chromophores & stimulate collagen production |
DE10052296C1 (en) | 2000-10-20 | 2002-04-04 | Braun Gmbh | Electrically-operated hair removal device has pulsed stroboscopic light signal provided by illumination device for illumination of relatively moving working elements |
JP2002200181A (en) * | 2000-10-31 | 2002-07-16 | Shigehiro Kubota | Laser treatment instrument |
US6506053B2 (en) | 2000-11-13 | 2003-01-14 | Peter E. Wiesel | Systems for treating teeth |
US6616447B1 (en) | 2000-11-15 | 2003-09-09 | Biolase Technology, Inc. | Device for dental care and whitening |
US20020071287A1 (en) | 2000-12-13 | 2002-06-13 | 3M Innovative Properties Company | Laser pointer with multiple color beams |
US6808532B2 (en) | 2000-12-15 | 2004-10-26 | Dan E. Andersen | Laser treatment for reducing wrinkles |
US6746444B2 (en) | 2000-12-18 | 2004-06-08 | Douglas J. Key | Method of amplifying a beneficial selective skin response to light energy |
JP2005502385A (en) | 2000-12-28 | 2005-01-27 | パロマー・メディカル・テクノロジーズ・インコーポレーテッド | Method and apparatus for performing skin therapy EMR treatment |
US20080183162A1 (en) | 2000-12-28 | 2008-07-31 | Palomar Medical Technologies, Inc. | Methods And Devices For Fractional Ablation Of Tissue |
US6623513B2 (en) | 2001-01-19 | 2003-09-23 | Advanced Photodynamic Technologies, Inc. | Apparatus and method of photodynamic eradication of organisms utilizing pyrrolnitrin |
CA2444891A1 (en) | 2001-01-22 | 2002-08-15 | Eric Larsen | Photodynamic stimulation device and methods |
ITMO20010008A1 (en) | 2001-01-29 | 2002-07-29 | Laserwave Srl | DEVICE FOR SKIN TREATMENTS |
DE60226964D1 (en) | 2001-02-12 | 2008-07-17 | Koninkl Philips Electronics Nv | SCHALLANTRIEBS TOOTHBRUSH WITH MULTIPLE CONTAINERS |
US6673095B2 (en) | 2001-02-12 | 2004-01-06 | Wound Healing Of Oklahoma, Inc. | Apparatus and method for delivery of laser light |
US20020110328A1 (en) | 2001-02-14 | 2002-08-15 | Bischel William K. | Multi-channel laser pump source for optical amplifiers |
US8106038B2 (en) | 2001-02-15 | 2012-01-31 | Qlt Inc. | Method for reducing or preventing PDT related inflammation |
US20030023284A1 (en) * | 2001-02-20 | 2003-01-30 | Vladimir Gartstein | Method and apparatus for the in-vivo treatment of pathogens |
US6682523B2 (en) * | 2001-02-21 | 2004-01-27 | John H. Shadduck | Devices and techniques for treating trabecular meshwork |
US6989007B2 (en) * | 2001-02-21 | 2006-01-24 | Solx, Inc. | Devices and techniques for treating glaucoma |
JP4034941B2 (en) | 2001-02-28 | 2008-01-16 | 株式会社ニデック | Laser therapy device |
US20020149326A1 (en) | 2001-03-01 | 2002-10-17 | Mikhail Inochkin | Flashlamp drive circuit |
US6888319B2 (en) | 2001-03-01 | 2005-05-03 | Palomar Medical Technologies, Inc. | Flashlamp drive circuit |
EP1665996A3 (en) | 2001-03-02 | 2007-11-28 | Palomar Medical Technologies, Inc. | Apparatus and method for photocosmetic and photodermatological treatment |
US20020127224A1 (en) | 2001-03-02 | 2002-09-12 | James Chen | Use of photoluminescent nanoparticles for photodynamic therapy |
US6497719B2 (en) | 2001-03-06 | 2002-12-24 | Henry Pearl | Apparatus and method for stimulating hair growth |
DE10112289A1 (en) | 2001-03-08 | 2002-09-26 | Optomed Optomedical Systems Gmbh | Irradiating device used for treating acne comprises a radiation source emitting a broad band spectrum in a specified region and operating in the pulse manner |
DE10123926A1 (en) | 2001-03-08 | 2002-09-19 | Optomed Optomedical Systems Gmbh | irradiation device |
US6503486B2 (en) * | 2001-03-12 | 2003-01-07 | Colgate Palmolive Company | Strip for whitening tooth surfaces |
JP2002272861A (en) | 2001-03-16 | 2002-09-24 | Terabyt:Kk | Light energy athletes' foot medical treatment machine |
GB0107853D0 (en) | 2001-03-29 | 2001-05-23 | Asclepion Meditec Ltd | Hand apparatus for light delivery |
WO2002078559A1 (en) | 2001-03-30 | 2002-10-10 | Koninklijke Philips Electronics N.V. | Skin treating device comprising a protected radiation exit opening |
US20020173777A1 (en) | 2001-03-30 | 2002-11-21 | Sand Bruce J. | Treatment of collagen |
WO2002082600A2 (en) | 2001-04-04 | 2002-10-17 | Coherent Deos | Q-switched cavity dumped co2 laser for material processing |
US7033348B2 (en) | 2001-04-10 | 2006-04-25 | The Research Foundation Of The City University Of New York | Gelatin based on Power-gel™ as solders for Cr4+laser tissue welding and sealing of lung air leak and fistulas in organs |
US7107996B2 (en) | 2001-04-10 | 2006-09-19 | Ganz Robert A | Apparatus and method for treating atherosclerotic vascular disease through light sterilization |
US6635052B2 (en) | 2001-04-11 | 2003-10-21 | Trimedyne, Inc. | Multi-fiber laser device for shrinking tissue |
US6733490B1 (en) | 2001-04-12 | 2004-05-11 | Iridex Corporation | Method and apparatus for controlling sub-clinical laser procedures with intra-operative monitoring of electrophysiological changes |
DE50107938D1 (en) | 2001-04-18 | 2005-12-08 | Georg Knott | IRRADIATOR IN PARTICULAR TO PHOTODYNAMIC DIAGNOSIS OR THERAPY |
DE10120787A1 (en) | 2001-04-25 | 2003-01-09 | Foerderung Von Medizin Bio Und | Remission-controlled device with laser handpiece for sensor-controlled selective laser therapy of blood vessels and skin tissues has multiple-sensor system e.g. using near infrared or visible radiation |
US6755647B2 (en) | 2001-04-26 | 2004-06-29 | New Photonics, Llc | Photocuring device with axial array of light emitting diodes and method of curing |
AU2002305313A1 (en) | 2001-04-30 | 2002-11-11 | Medtronic, Inc. | Implantable medical device and patch system |
US8840918B2 (en) | 2001-05-01 | 2014-09-23 | A. V. Topchiev Institute of Petrochemical Synthesis, Russian Academy of Sciences | Hydrogel compositions for tooth whitening |
EP1386145B8 (en) | 2001-05-04 | 2012-08-29 | Thermo Scientific Portable Analytical Instruments Inc. | X-ray fluorescence combined with laser induced photon spectroscopy |
US6572634B2 (en) | 2001-05-07 | 2003-06-03 | Myung H. Koo | Nose end adjusting device |
GB0111271D0 (en) | 2001-05-09 | 2001-06-27 | Asclepion Meditec Ltd | A method of stimulating collagen formation |
CN1879573B (en) | 2001-05-23 | 2012-05-30 | 帕洛玛医疗技术公司 | Cooling system for a photo cosmetic device |
DE10125772C2 (en) | 2001-05-26 | 2003-06-18 | Duerr Dental Gmbh Co Kg | Dental or endoscopic camera |
US6679837B2 (en) * | 2001-06-01 | 2004-01-20 | Intlas Ltd. | Laser light irradiation apparatus |
WO2002102419A2 (en) * | 2001-06-15 | 2002-12-27 | Uv-Solutions, Llc. | Method and apparatus for sterilizing or disinfecting a region through a bandage |
US6770069B1 (en) | 2001-06-22 | 2004-08-03 | Sciton, Inc. | Laser applicator |
EP1414516A2 (en) | 2001-06-26 | 2004-05-06 | Photomed Technologies, Inc. | Therapeutic methods using electromagnetic radiation |
DE10130278B4 (en) | 2001-06-26 | 2005-11-03 | Carl Zeiss Meditec Ag | Method and device for representing an operating area during laser operations |
AU2002316500A1 (en) | 2001-07-02 | 2003-01-21 | Palomar Medical Technologies, Inc. | Laser device for medical/cosmetic procedures |
US20030009158A1 (en) | 2001-07-09 | 2003-01-09 | Perricone Nicholas V. | Skin treatments using blue and violet light |
CH695085A5 (en) * | 2001-07-13 | 2005-12-15 | Mibelle Ag Cosmetics | Formulations for care of the skin after laser treatment and / or chemical peels, and use of formulations. |
ITPD20010187A1 (en) | 2001-07-23 | 2003-01-23 | Cutech Srl | POLYPHERIC FOLLICLE TREATMENT, IN PARTICULAR AGAINST HAIR LOSS |
US7170034B2 (en) * | 2002-02-05 | 2007-01-30 | Radiancy Inc. | Pulsed electric shaver |
JP4485788B2 (en) * | 2001-07-27 | 2010-06-23 | コーニンクレッカ フィリップス エレクトロニクス エヌ ヴィ | Apparatus for skin treatment having a processor for determining the dose of a radiation pulse |
US6607525B2 (en) | 2001-08-01 | 2003-08-19 | Nicolas Franco | Apparatus and method for treating urinary stress incontinence |
US6939344B2 (en) * | 2001-08-02 | 2005-09-06 | Syneron Medical Ltd. | Method for controlling skin temperature during thermal treatment |
US7018396B2 (en) | 2001-08-07 | 2006-03-28 | New England Medical Center Hospitals, Inc. | Method of treating acne |
JP2003052843A (en) | 2001-08-08 | 2003-02-25 | Terabyt:Kk | Wrinkle removing laser treatment device |
US20030032900A1 (en) | 2001-08-08 | 2003-02-13 | Engii (2001) Ltd. | System and method for facial treatment |
US20040260210A1 (en) | 2003-06-23 | 2004-12-23 | Engii (2001) Ltd. | System and method for face and body treatment |
JP2005500108A (en) | 2001-08-15 | 2005-01-06 | リライアント テクノロジーズ,インコーポレイティド | Apparatus and method for thermal excision of biological tissue |
US7094252B2 (en) | 2001-08-21 | 2006-08-22 | Cooltouch Incorporated | Enhanced noninvasive collagen remodeling |
US6942658B1 (en) | 2001-08-24 | 2005-09-13 | Boilase Technology, Inc. | Radiation emitting apparatus with spatially controllable output energy distributions |
US7384419B2 (en) | 2002-08-26 | 2008-06-10 | Biolase Technology, Inc. | Tapered fused waveguide for delivering treatment electromagnetic radiation toward a target surfaced |
AU2002341359A1 (en) | 2001-09-27 | 2003-04-07 | Galil Medical Ltd. | Apparatus and method for cryosurgical treatment of tumors of the breast |
US6561808B2 (en) | 2001-09-27 | 2003-05-13 | Ceramoptec Industries, Inc. | Method and tools for oral hygiene |
US6629989B2 (en) | 2001-10-18 | 2003-10-07 | Shimadzu Corporation | Phototherapy device for pressure pain point therapy and trigger point therapy |
US7144248B2 (en) | 2001-10-18 | 2006-12-05 | Irwin Dean S | Device for oral UV photo-therapy |
US6952856B2 (en) | 2001-11-06 | 2005-10-11 | Create Co., Ltd. | Ionic toothbrush |
US20040147984A1 (en) | 2001-11-29 | 2004-07-29 | Palomar Medical Technologies, Inc. | Methods and apparatus for delivering low power optical treatments |
US6648904B2 (en) | 2001-11-29 | 2003-11-18 | Palomar Medical Technologies, Inc. | Method and apparatus for controlling the temperature of a surface |
US6623272B2 (en) | 2001-11-30 | 2003-09-23 | Kathleen Clemans | Light-emitting toothbrush and method of whitening teeth |
WO2003049633A1 (en) * | 2001-12-10 | 2003-06-19 | Inolase 2002 Ltd. | Method and apparatus for improving safety during exposure to a monochromatic light source |
EP1627662B1 (en) | 2004-06-10 | 2011-03-02 | Candela Corporation | Apparatus for vacuum-assisted light-based treatments of the skin |
US20030216719A1 (en) | 2001-12-12 | 2003-11-20 | Len Debenedictis | Method and apparatus for treating skin using patterns of optical energy |
US20040082940A1 (en) | 2002-10-22 | 2004-04-29 | Michael Black | Dermatological apparatus and method |
US20030109787A1 (en) | 2001-12-12 | 2003-06-12 | Michael Black | Multiple laser diagnostics |
US20030109860A1 (en) | 2001-12-12 | 2003-06-12 | Michael Black | Multiple laser treatment |
DE60226635D1 (en) | 2001-12-14 | 2008-06-26 | Monteris Medical Inc | HYPERTHERMIE TREATMENT AND ASSOCIATED PROBE |
US6692252B2 (en) | 2001-12-17 | 2004-02-17 | Ultradent Products, Inc. | Heat sink with geometric arrangement of LED surfaces |
AU2002367397A1 (en) | 2001-12-27 | 2003-07-24 | Palomar Medical Technologies, Inc. | Method and apparatus for improved vascular related treatment |
JP2003192809A (en) | 2001-12-28 | 2003-07-09 | Mitsubishi Paper Mills Ltd | Heat resistant insulation sheet |
US6863781B2 (en) * | 2002-02-26 | 2005-03-08 | Massachusetts Institute Of Technology | Process for photocatalysis and two-electron mixed-valence complexes |
US7086861B2 (en) | 2002-03-01 | 2006-08-08 | Pitz Richard J | System for dispensing viscous materials |
EP1340486A1 (en) | 2002-03-01 | 2003-09-03 | Cognis France S.A. | Use of sugar esters |
US7081128B2 (en) | 2002-03-04 | 2006-07-25 | Hart Barry M | Phototherapy device and method of use |
US6927857B2 (en) | 2002-03-09 | 2005-08-09 | Kimberly-Clark Worldwide, Inc. | Process for the detection of marked components of a composite article using infrared blockers |
US6942663B2 (en) * | 2002-03-12 | 2005-09-13 | Board Of Regents, The University Of Texas System | Laser treatment of cutaneous vascular lesions |
IL163946A0 (en) | 2002-03-12 | 2005-12-18 | Gen Hospital Corp | Method and apparatus for hair growth managment |
ES2621521T3 (en) * | 2002-03-15 | 2017-07-04 | The General Hospital Corporation | Method for selective breakage of fatty tissue by controlled cooling |
US8840608B2 (en) | 2002-03-15 | 2014-09-23 | The General Hospital Corporation | Methods and devices for selective disruption of fatty tissue by controlled cooling |
GB0301737D0 (en) | 2003-01-24 | 2003-02-26 | Enfis Ltd | Method and device for treatment of skin conditions |
US6955684B2 (en) | 2002-03-29 | 2005-10-18 | Savage Jr Henry C | Portable light delivery apparatus and methods |
US20030187319A1 (en) | 2002-03-29 | 2003-10-02 | Olympus Optical Co., Ltd. | Sentinel lymph node detecting apparatus, and method thereof |
WO2003085376A2 (en) | 2002-04-03 | 2003-10-16 | The Regents Of The University Of California | System and method for quantitative or qualitative measurement of exogenous substances in tissue and other materials using laser-induced fluorescence spectroscopy |
US7647092B2 (en) * | 2002-04-05 | 2010-01-12 | Massachusetts Institute Of Technology | Systems and methods for spectroscopy of biological tissue |
DE60324125D1 (en) | 2002-04-09 | 2008-11-27 | Altshuler Gregory | DEVICE FOR PROCESSING HARD MATERIALS |
US8348933B2 (en) * | 2002-04-09 | 2013-01-08 | Laser Abrasive Technologies, Llc | Method and apparatus for processing hard material |
US7322972B2 (en) * | 2002-04-10 | 2008-01-29 | The Regents Of The University Of California | In vivo port wine stain, burn and melanin depth determination using a photoacoustic probe |
AU2003223613A1 (en) | 2002-04-16 | 2003-11-03 | Lumerx, Inc | Chemiluminescent light source using visible light for biotherapy |
US6917715B2 (en) | 2002-04-19 | 2005-07-12 | International Business Machines Corporation | Foveal priority in stereoscopic remote viewing system |
US20060293727A1 (en) | 2002-05-09 | 2006-12-28 | Greg Spooner | System and method for treating exposed tissue with light emitting diodes |
GB2390021A (en) | 2002-05-17 | 2003-12-31 | Ian Charlesworth | Hand-held led apparatus for treating acne |
US7135033B2 (en) | 2002-05-23 | 2006-11-14 | Palomar Medical Technologies, Inc. | Phototreatment device for use with coolants and topical substances |
US20070038206A1 (en) | 2004-12-09 | 2007-02-15 | Palomar Medical Technologies, Inc. | Photocosmetic device |
AU2002325533A1 (en) | 2002-05-31 | 2003-12-19 | Ya-Man Ltd. | Laser depilator |
DE10225749C5 (en) | 2002-06-10 | 2009-09-10 | Elexxion Gmbh | Medical equipment for treatments in the dental field by means of a laser |
US20030233138A1 (en) | 2002-06-12 | 2003-12-18 | Altus Medical, Inc. | Concentration of divergent light from light emitting diodes into therapeutic light energy |
BR0312430A (en) * | 2002-06-19 | 2005-04-26 | Palomar Medical Tech Inc | Method and apparatus for treating skin and subcutaneous conditions |
JP2006500972A (en) | 2002-06-19 | 2006-01-12 | パロマー・メディカル・テクノロジーズ・インコーポレイテッド | Method and apparatus for treating tissue at a depth by radiant heat |
US7001413B2 (en) | 2002-07-03 | 2006-02-21 | Life Support Technologies, Inc. | Methods and apparatus for light therapy |
US7201766B2 (en) | 2002-07-03 | 2007-04-10 | Life Support Technologies, Inc. | Methods and apparatus for light therapy |
US7282723B2 (en) | 2002-07-09 | 2007-10-16 | Medispectra, Inc. | Methods and apparatus for processing spectral data for use in tissue characterization |
FR2842088B1 (en) | 2002-07-10 | 2004-12-10 | Seb Sa | ELECTRIC KETTLE |
US20040015158A1 (en) * | 2002-07-19 | 2004-01-22 | To-Mu Chen | Transilluminator device |
AU2003265308A1 (en) | 2002-07-25 | 2004-02-16 | Jonathan S. Dahm | Method and apparatus for using light emitting diodes for curing |
US6902397B2 (en) | 2002-08-01 | 2005-06-07 | Sunstar Americas, Inc. | Enhanced dental hygiene system with direct UVA photoexcitation |
US6780177B2 (en) | 2002-08-27 | 2004-08-24 | Board Of Trustees Of The University Of Arkansas | Conductive interstitial thermal therapy device |
US6860896B2 (en) | 2002-09-03 | 2005-03-01 | Jeffrey T. Samson | Therapeutic method and apparatus |
WO2004026099A2 (en) | 2002-09-20 | 2004-04-01 | Iridex Corporation | Apparatus for real time measure/control of intra-operative effects during laser thermal treatments using light scattering |
US20070219605A1 (en) | 2006-03-20 | 2007-09-20 | Palomar Medical Technologies, Inc. | Treatment of tissue volume with radiant energy |
US20070213792A1 (en) | 2002-10-07 | 2007-09-13 | Palomar Medical Technologies, Inc. | Treatment Of Tissue Volume With Radiant Energy |
WO2004033040A1 (en) * | 2002-10-07 | 2004-04-22 | Palomar Medical Technologies, Inc. | Apparatus for performing photobiostimulation |
US7524316B2 (en) | 2002-10-31 | 2009-04-28 | Cooltouch, Inc. | Endovenous closure of varicose veins with mid infrared laser |
US6824542B2 (en) | 2002-11-08 | 2004-11-30 | Harvey H. Jay | Temporary hair removal method |
US6916316B2 (en) | 2002-11-08 | 2005-07-12 | Harvey H. Jay | Hair treatment method |
US7699058B1 (en) | 2002-11-08 | 2010-04-20 | Jay Harvey H | Hair treatment method |
US7931028B2 (en) | 2003-08-26 | 2011-04-26 | Jay Harvey H | Skin injury or damage prevention method using optical radiation |
WO2004043543A1 (en) | 2002-11-12 | 2004-05-27 | Palomar Medical Technologies, Inc. | Apparatus for performing optical dermatology |
US7377917B2 (en) | 2002-12-09 | 2008-05-27 | The Trustees Of Dartmouth College | Feedback control of thermokeratoplasty treatments |
US6866678B2 (en) | 2002-12-10 | 2005-03-15 | Interbational Technology Center | Phototherapeutic treatment methods and apparatus |
US6991644B2 (en) | 2002-12-12 | 2006-01-31 | Cutera, Inc. | Method and system for controlled spatially-selective epidermal pigmentation phototherapy with UVA LEDs |
AU2003301111A1 (en) | 2002-12-20 | 2004-07-22 | Palomar Medical Technologies, Inc. | Apparatus for light treatment of acne and other disorders of follicles |
IL154101A0 (en) | 2003-01-23 | 2003-07-31 | Univ Ramot | Minimally invasive controlled surgical system with feedback |
US20040143920A1 (en) | 2003-01-24 | 2004-07-29 | Dr. Fresh, Inc. | Illuminated flashing toothbrush and method of use |
CN1771073A (en) | 2003-02-10 | 2006-05-10 | 帕洛玛医疗技术公司 | Light emitting oral appliance and method of use |
US7704247B2 (en) | 2003-02-13 | 2010-04-27 | Barbara Ann Soltz | Dual fiber-optic surgical apparatus |
US20040161213A1 (en) | 2003-02-15 | 2004-08-19 | Tsung-Ting Lee | Fiber optic display device |
JP2006518266A (en) | 2003-02-19 | 2006-08-10 | パロマー・メディカル・テクノロジーズ・インコーポレイテッド | Method and apparatus for treating fake folliculitis |
WO2004077020A2 (en) | 2003-02-25 | 2004-09-10 | Spectragenics, Inc. | Skin sensing method and apparatus |
WO2004075721A2 (en) | 2003-02-25 | 2004-09-10 | Spectragenics, Inc. | Self-contained, diode-laser-based dermatologic treatment apparatus and metod |
US20040176754A1 (en) | 2003-03-06 | 2004-09-09 | Island Tobin C. | Method and device for sensing skin contact |
US8709003B2 (en) * | 2003-02-25 | 2014-04-29 | Tria Beauty, Inc. | Capacitive sensing method and device for detecting skin |
US20040176764A1 (en) | 2003-03-03 | 2004-09-09 | Centerpulse Spine-Tech, Inc. | Apparatus and method for spinal distraction using a flip-up portal |
US7104985B2 (en) | 2003-03-06 | 2006-09-12 | Martinelli Michael A | Apparatus and method for causing selective necrosis of abnormal cells |
US7006223B2 (en) | 2003-03-07 | 2006-02-28 | 3Gen, Llc. | Dermoscopy epiluminescence device employing cross and parallel polarization |
KR20050107558A (en) | 2003-03-13 | 2005-11-14 | 라디언시 인크. | Electric shaver with vibrating head |
US7972330B2 (en) | 2003-03-27 | 2011-07-05 | Terumo Kabushiki Kaisha | Methods and apparatus for closing a layered tissue defect |
DE202004021226U1 (en) | 2003-03-27 | 2007-07-26 | The General Hospital Corp., Boston | Device for dermatological treatment and fractional surface renewal of the skin |
US7153298B1 (en) * | 2003-03-28 | 2006-12-26 | Vandolay, Inc. | Vascular occlusion systems and methods |
US20040199151A1 (en) | 2003-04-03 | 2004-10-07 | Ceramoptec Industries, Inc. | Power regulated medical underskin irradiation treament system |
US20050116673A1 (en) | 2003-04-18 | 2005-06-02 | Rensselaer Polytechnic Institute | Methods and systems for controlling the operation of a tool |
US6953341B2 (en) | 2003-08-20 | 2005-10-11 | Oralum, Llc | Toothpick for light treatment of body structures |
US6989023B2 (en) * | 2003-07-08 | 2006-01-24 | Oralum, Llc | Hygienic treatments of body structures |
US7144247B2 (en) | 2003-04-25 | 2006-12-05 | Oralum, Llc | Hygienic treatments of structures in body cavities |
US20040234460A1 (en) | 2003-05-21 | 2004-11-25 | Tarver Jeanna Gail | Tooth whitening compositions and methods for using the same |
JP3896097B2 (en) | 2003-06-27 | 2007-03-22 | 日本オプネクスト株式会社 | Receptacle type optical module |
JP2005027702A (en) | 2003-07-07 | 2005-02-03 | Ya Man Ltd | Face treatment mask |
WO2005007003A1 (en) | 2003-07-11 | 2005-01-27 | Reliant Technologies, Inc. | Method and apparatus for fractional photo therapy of skin |
US20050015077A1 (en) * | 2003-07-14 | 2005-01-20 | Yevgeniy Kuklin | Method and apparatus for skin treatment using near infrared laser radiation |
US7291140B2 (en) | 2003-07-18 | 2007-11-06 | Cutera, Inc. | System and method for low average power dermatologic light treatment device |
US7145108B2 (en) | 2003-07-22 | 2006-12-05 | Kaz, Incorporated | Configurable heating pad controller |
US8623002B2 (en) | 2003-07-29 | 2014-01-07 | Koninklijke Philips N.V. | Electromagnetic radiation delivery apparatus |
US7208007B2 (en) | 2003-08-07 | 2007-04-24 | Cutera, Inc. | System and method utilizing guided fluorescence for high intensity applications |
US20050065502A1 (en) | 2003-08-11 | 2005-03-24 | Richard Stoltz | Enabling or blocking the emission of an ablation beam based on color of target |
US8083784B2 (en) | 2003-08-19 | 2011-12-27 | Photonx Health Corporation | Photon therapy method and apparatus |
US7722600B2 (en) | 2003-08-25 | 2010-05-25 | Cutera, Inc. | System and method for heating skin using light to provide tissue treatment |
US8870856B2 (en) | 2003-08-25 | 2014-10-28 | Cutera, Inc. | Method for heating skin using light to provide tissue treatment |
US20050049467A1 (en) | 2003-08-28 | 2005-03-03 | Georgios Stamatas | Method for assessing pigmented skin |
US7356053B2 (en) | 2003-10-06 | 2008-04-08 | Continuum Electro-Optics, Inc. | Mode-locked laser with variable pulse duration |
US20050102213A1 (en) | 2003-11-07 | 2005-05-12 | Serkan Savasoglu | Systems and methods for accreting remarketable convertible securities |
US20050113890A1 (en) | 2003-11-25 | 2005-05-26 | Ritchie Paul G. | Energy delivery device with self-heat calibration |
US7118564B2 (en) | 2003-11-26 | 2006-10-10 | Ethicon Endo-Surgery, Inc. | Medical treatment system with energy delivery device for limiting reuse |
ITBO20030717A1 (en) | 2003-11-27 | 2005-05-28 | Espansione Marketing S P A | LIGHT IRRADIATION UNIT. |
US7282060B2 (en) | 2003-12-23 | 2007-10-16 | Reliant Technologies, Inc. | Method and apparatus for monitoring and controlling laser-induced tissue treatment |
US7766903B2 (en) | 2003-12-24 | 2010-08-03 | The Board Of Trustees Of The Leland Stanford Junior University | Patterned laser treatment of the retina |
US7090670B2 (en) | 2003-12-31 | 2006-08-15 | Reliant Technologies, Inc. | Multi-spot laser surgical apparatus and method |
US7220254B2 (en) | 2003-12-31 | 2007-05-22 | Palomar Medical Technologies, Inc. | Dermatological treatment with visualization |
US7041100B2 (en) | 2004-01-21 | 2006-05-09 | Syneron Medical Ltd. | Method and system for selective electro-thermolysis of skin targets |
US20050165315A1 (en) | 2004-01-27 | 2005-07-28 | Infraredx, Inc. | Side firing fiber optic array probe |
EP1718366A4 (en) | 2004-02-06 | 2007-11-21 | Daniel Barolet | Method and device for the treatment of mammalian tissues |
US7344494B2 (en) | 2004-02-09 | 2008-03-18 | Karl Storz Development Corp. | Endoscope with variable direction of view module |
DE102004008681A1 (en) | 2004-02-21 | 2005-09-08 | Eads Space Transportation Gmbh | Method for energy transmission by means of coherent electromagnetic radiation |
US6893259B1 (en) | 2004-03-08 | 2005-05-17 | Igor Reizenson | Oral hygiene device and method of use therefor |
US20050203496A1 (en) | 2004-03-12 | 2005-09-15 | Ritchie Paul G. | Medical apparatus and method useful for thermal treatment of a lumen |
US20050203497A1 (en) | 2004-03-12 | 2005-09-15 | Trevor Speeg | Medical apparatus and method useful for positioning energy delivery device |
JPWO2005092438A1 (en) | 2004-03-26 | 2008-05-22 | ヤーマン株式会社 | Treatment equipment |
JP4504718B2 (en) | 2004-03-31 | 2010-07-14 | テルモ株式会社 | Heat treatment device |
WO2005096981A2 (en) | 2004-04-01 | 2005-10-20 | The General Hospital Corporation | Method and apparatus for dermatological treatment |
WO2005099369A2 (en) | 2004-04-09 | 2005-10-27 | Palomar Medical Technologies, Inc. | Emr treated islets |
US20090069741A1 (en) | 2004-04-09 | 2009-03-12 | Palomar Medical Technologies, Inc. | Methods And Devices For Fractional Ablation Of Tissue For Substance Delivery |
US20080132886A1 (en) | 2004-04-09 | 2008-06-05 | Palomar Medical Technologies, Inc. | Use of fractional emr technology on incisions and internal tissues |
US20070208252A1 (en) | 2004-04-21 | 2007-09-06 | Acclarent, Inc. | Systems and methods for performing image guided procedures within the ear, nose, throat and paranasal sinuses |
AT500141B1 (en) | 2004-04-28 | 2008-03-15 | W & H Dentalwerk Buermoos Gmbh | DENTAL LASER TREATMENT DEVICE |
US20050251116A1 (en) | 2004-05-05 | 2005-11-10 | Minnow Medical, Llc | Imaging and eccentric atherosclerotic material laser remodeling and/or ablation catheter |
US20050251117A1 (en) | 2004-05-07 | 2005-11-10 | Anderson Robert S | Apparatus and method for treating biological external tissue |
US7842029B2 (en) | 2004-05-07 | 2010-11-30 | Aesthera | Apparatus and method having a cooling material and reduced pressure to treat biological external tissue |
EP1797836A1 (en) | 2004-05-13 | 2007-06-20 | Francisco Javier Arcusa Villacampa | Handpiece for medical/surgical treatments |
US7537735B2 (en) | 2004-05-21 | 2009-05-26 | Biomerieux, Inc. | Aspirator systems having an aspirator tip optical level detector and methods for using the same |
WO2006006123A1 (en) | 2004-07-09 | 2006-01-19 | Koninklijke Philips Electronics N.V. | Light modulator |
US20060007965A1 (en) * | 2004-07-12 | 2006-01-12 | Nikolai Tankovich | Passive Q-switch modulated fiber laser |
MX2007000613A (en) * | 2004-07-16 | 2007-06-25 | Johnson & Johnson | Treatment of skin with light and a benefit agent. |
US7333698B2 (en) | 2004-08-05 | 2008-02-19 | Polyoptics Ltd | Optical scanning device |
US20060056589A1 (en) | 2004-08-31 | 2006-03-16 | Massachusetts Institute Of Technology | Radiation-induced cellular adaptive response |
US20060047281A1 (en) | 2004-09-01 | 2006-03-02 | Syneron Medical Ltd. | Method and system for invasive skin treatment |
US7519210B2 (en) | 2004-09-09 | 2009-04-14 | Raphael Hirsch | Method of assessing localized shape and temperature of the human body |
WO2006036968A2 (en) | 2004-09-28 | 2006-04-06 | Reliant Technologies, Inc. | Methods and apparatus for modulation of the immune response using light-based fractional treatment |
DE602005011984D1 (en) * | 2004-10-05 | 2009-02-05 | Koninkl Philips Electronics Nv | SKIN TREATMENT DEVICE WITH RADIATION EMISSION PROTECTION |
PT2409731T (en) | 2004-10-06 | 2017-10-23 | Guided Therapy Systems Llc | System for controlled thermal treatment of human superficial tissue |
US20060122584A1 (en) | 2004-10-27 | 2006-06-08 | Bommannan D B | Apparatus and method to treat heart disease using lasers to form microchannels |
US20060094988A1 (en) | 2004-10-28 | 2006-05-04 | Tosaya Carol A | Ultrasonic apparatus and method for treating obesity or fat-deposits or for delivering cosmetic or other bodily therapy |
US20060118127A1 (en) | 2004-12-06 | 2006-06-08 | Chinn Douglas O | Tissue protective system and method for thermoablative therapies |
AU2005314712A1 (en) | 2004-12-09 | 2006-06-15 | Palomar Medical Technologies, Inc. | Oral appliance with heat transfer mechanism |
JP2006192073A (en) | 2005-01-13 | 2006-07-27 | Matsushita Electric Ind Co Ltd | Phototherapy apparatus |
US8027710B1 (en) | 2005-01-28 | 2011-09-27 | Patrick Dannan | Imaging system for endoscopic surgery |
US20060173480A1 (en) | 2005-01-31 | 2006-08-03 | Yi Zhang | Safety penetrating method and apparatus into body cavities, organs, or potential spaces |
US7291141B2 (en) | 2005-02-02 | 2007-11-06 | Jay Harvey H | Method and apparatus for enhancing hair removal |
US7258695B2 (en) | 2005-02-08 | 2007-08-21 | Sonetics International | Hair restoration device and methods of using and manufacturing the same |
US20080183250A1 (en) | 2005-02-11 | 2008-07-31 | Hanafi Tanojo | Compositions and methods for treating or preventing skin inflammation via restoration of skin barrier function |
US20060253176A1 (en) | 2005-02-18 | 2006-11-09 | Palomar Medical Technologies, Inc. | Dermatological treatment device with deflector optic |
US20060271028A1 (en) | 2005-02-18 | 2006-11-30 | Palomar Medical Technologies, Inc. | Dermatological treatment device |
US20060217787A1 (en) | 2005-03-23 | 2006-09-28 | Eastman Kodak Company | Light therapy device |
US20080294150A1 (en) | 2005-04-01 | 2008-11-27 | Palomar Medical Technologies, Inc. | Photoselective Islets In Skin And Other Tissues |
US7975702B2 (en) | 2005-04-05 | 2011-07-12 | El.En. S.P.A. | System and method for laser lipolysis |
US7856985B2 (en) | 2005-04-22 | 2010-12-28 | Cynosure, Inc. | Method of treatment body tissue using a non-uniform laser beam |
US8406858B2 (en) | 2005-04-29 | 2013-03-26 | The Regents Of The University Of Colorado, A Body Corporate | Multi-excitation diagnostic system and methods for classification of tissue |
US8127771B2 (en) | 2005-05-18 | 2012-03-06 | Cooltouch Incorporated | Treatment of cellulite and adipose tissue with mid-infrared radiation |
US7217265B2 (en) | 2005-05-18 | 2007-05-15 | Cooltouch Incorporated | Treatment of cellulite with mid-infrared radiation |
US7624640B2 (en) | 2005-06-03 | 2009-12-01 | Brown University | Opto-acoustic methods and apparatus for performing high resolution acoustic imaging and other sample probing and modification operations |
US20060293728A1 (en) | 2005-06-24 | 2006-12-28 | Roersma Michiel E | Device and method for low intensity optical hair growth control |
KR20080039920A (en) | 2005-07-22 | 2008-05-07 | 토모테라피 인코포레이티드 | System and method of evaluating dose delivered by a radiation therapy system |
ATE499893T1 (en) | 2005-07-26 | 2011-03-15 | Koninkl Philips Electronics Nv | HAIR REMOVAL SYSTEM |
AU2006278255A1 (en) | 2005-08-08 | 2007-02-15 | Palomar Medical Technologies, Inc. | Eye-safe photocosmetic device |
AU2006279865B8 (en) | 2005-08-12 | 2013-01-31 | Board Of Regents, The University Of Texas System | Systems, devices, and methods for optically clearing tissue |
WO2007027962A2 (en) | 2005-08-29 | 2007-03-08 | Reliant Technologies, Inc. | Method and apparatus for monitoring and controlling thermally induced tissue treatment |
US8795262B2 (en) | 2005-08-30 | 2014-08-05 | Azienda Usl 4 Prato | Optical fiber laser device and method for ocular suturing |
EP1928540A4 (en) | 2005-09-07 | 2010-03-10 | The Foundry Inc | Apparatus and method for disrupting subcutaneous structures |
US7967763B2 (en) | 2005-09-07 | 2011-06-28 | Cabochon Aesthetics, Inc. | Method for treating subcutaneous tissues |
JP2009509140A (en) | 2005-09-15 | 2009-03-05 | パロマー・メデイカル・テクノロジーズ・インコーポレーテツド | Skin optical determination device |
US20070088206A1 (en) | 2005-10-14 | 2007-04-19 | Peyman Gholam A | Photoacoustic measurement of analyte concentration in the eye |
US20070121069A1 (en) | 2005-11-16 | 2007-05-31 | Andersen Dan E | Multiple spot photomedical treatment using a laser indirect ophthalmoscope |
US9248317B2 (en) | 2005-12-02 | 2016-02-02 | Ulthera, Inc. | Devices and methods for selectively lysing cells |
WO2007070881A2 (en) | 2005-12-15 | 2007-06-21 | Laser Abrasive Technologies, Llc | Method and apparatus for treatment of solid material including hard tissue |
DE102006001849A1 (en) | 2006-01-13 | 2007-07-19 | Siemens Ag | Mapping catheter for determining image data from the heart comprises a thermal sensor for determining temperature data on the tip of the catheter in the distal region of the catheter |
JP2007190566A (en) | 2006-01-17 | 2007-08-02 | Miyachi Technos Corp | Fiber laser beam machining apparatus |
EP1973510B1 (en) | 2006-01-20 | 2010-09-22 | Eleme Medical Inc. | Mechanical massage device |
US20070179470A1 (en) | 2006-02-01 | 2007-08-02 | Toombs Ella L | Disposable transparent liposuction cannula/handle |
US20070194717A1 (en) | 2006-02-17 | 2007-08-23 | Palomar Medical Technologies, Inc. | Lamp for use in a tissue treatment device |
US7727516B2 (en) | 2006-02-28 | 2010-06-01 | The Procter & Gamble Company | Reduction of hair growth |
EP2270039B1 (en) | 2006-03-06 | 2013-05-29 | Caregen Co., Ltd. | Peptides having activities of insulin like growth factor-1 and their uses |
US7441224B2 (en) | 2006-03-09 | 2008-10-21 | Motorola, Inc. | Streaming kernel selection for reconfigurable processor |
US9675821B2 (en) | 2006-03-14 | 2017-06-13 | Boston Scientific Scimed, Inc. | Device for thermal treatment of tissue and for temperature measurement of tissue providing feedback |
EP1839705A1 (en) | 2006-03-27 | 2007-10-03 | Universidad de Alcala | Transcutaneous laser therapy patch |
US20070255355A1 (en) | 2006-04-06 | 2007-11-01 | Palomar Medical Technologies, Inc. | Apparatus and method for skin treatment with compression and decompression |
WO2007129424A1 (en) | 2006-04-14 | 2007-11-15 | Sumitomo Electric Industries, Ltd. | Treatment device and treatment method |
WO2007122611A2 (en) | 2006-04-20 | 2007-11-01 | Nano Pass Technologies Ltd. | Device and methods combining vibrating micro-protrusions with phototherapy |
US20070260230A1 (en) | 2006-05-04 | 2007-11-08 | Reliant Technologies, Inc. | Opto-mechanical Apparatus and Method for Dermatological Treatment |
US8136531B2 (en) | 2006-05-08 | 2012-03-20 | Chariff Mark D | Device and method for treating musculo-skeletal injury and pain by application of laser light therapy |
US20070264625A1 (en) | 2006-05-11 | 2007-11-15 | Reliant Technologies, Inc. | Apparatus and Method for Ablation-Related Dermatological Treatment of Selected Targets |
DE102006023540A1 (en) | 2006-05-19 | 2007-11-22 | Francotyp-Postalia Gmbh | Process for the free spraying of the nozzles of an inkjet print head |
US8585707B2 (en) | 2006-06-07 | 2013-11-19 | Gary S. Rogers | Continuous low irradiance photodynamic therapy method |
JP2009542330A (en) | 2006-06-27 | 2009-12-03 | パロマー・メデイカル・テクノロジーズ・インコーポレーテツド | Handheld light beauty equipment |
US20080004608A1 (en) * | 2006-06-30 | 2008-01-03 | Alcon, Inc. | Multifunction surgical probe |
US8786554B2 (en) | 2006-07-10 | 2014-07-22 | Atmel Corporation | Priority and combination suppression techniques (PST/CST) for a capacitive keyboard |
ES2557168T3 (en) | 2006-07-13 | 2016-01-22 | Reliant Technologies, Llc | Device for adjustable fractional optical dermatological treatment |
US7586957B2 (en) | 2006-08-02 | 2009-09-08 | Cynosure, Inc | Picosecond laser apparatus and methods for its operation and use |
US20080058782A1 (en) | 2006-08-29 | 2008-03-06 | Reliant Technologies, Inc. | Method and apparatus for monitoring and controlling density of fractional tissue treatments |
WO2008067334A2 (en) | 2006-11-27 | 2008-06-05 | Rejuvedent Llc | A method and apparatus for hard tissue treatment and modification |
US20080140164A1 (en) | 2006-12-06 | 2008-06-12 | Clrs Technology Corporation | Light emitting therapeutic devices and methods |
AU2007333079A1 (en) | 2006-12-12 | 2008-06-19 | Curve Medical Llc | Laser energy device for soft tissue removal |
WO2008074005A1 (en) | 2006-12-13 | 2008-06-19 | Palomar Medical Technologies, Inc. | Cosmetic and biomedical applications of ultrasonic energy and methods of generation thereof |
US20080154247A1 (en) | 2006-12-20 | 2008-06-26 | Reliant Technologies, Inc. | Apparatus and method for hair removal and follicle devitalization |
WO2008089292A1 (en) * | 2007-01-16 | 2008-07-24 | Rejuvedent Llc | Method and apparatus for diagnostic and treatment using hard tissue or material microperforation |
RU2421257C2 (en) | 2007-01-26 | 2011-06-20 | Панасоник Электрик Воркс Ко., Лтд. | Hair growth control apparatus |
US20080186591A1 (en) | 2007-02-01 | 2008-08-07 | Palomar Medical Technologies, Inc. | Dermatological device having a zoom lens system |
EP2155098A4 (en) * | 2007-06-08 | 2013-11-06 | Cynosure Inc | Thermal surgery safety apparatus and method |
US20080319430A1 (en) | 2007-06-21 | 2008-12-25 | Palomar Medical Technologies, Inc. | Eye-Safe Device For Treatment Of Skin Tissue |
US20090018624A1 (en) * | 2007-07-13 | 2009-01-15 | Juniper Medical, Inc. | Limiting use of disposable system patient protection devices |
US8103355B2 (en) * | 2007-07-16 | 2012-01-24 | Invasix Ltd | Method and device for minimally invasive skin and fat treatment |
EP2207595A4 (en) * | 2007-10-19 | 2012-10-24 | Lockheed Corp | System and method for conditioning animal tissue using laser light |
AU2009205297A1 (en) | 2008-01-17 | 2009-07-23 | Syneron Medical Ltd. | A hair removal apparatus for personal use and the method of using same |
WO2009108933A2 (en) | 2008-02-28 | 2009-09-03 | Palomar Medical Technologies, Inc. | Systems and methods for treatment of soft tissue |
US20090222068A1 (en) | 2008-02-29 | 2009-09-03 | Clrs Technology Corporation | Rapid flash optical therapy |
WO2009117437A1 (en) | 2008-03-17 | 2009-09-24 | Palomar Medical Technologies, Inc. | Method and apparatus for fractional deformation and treatment of tissue |
WO2010017556A1 (en) | 2008-08-08 | 2010-02-11 | Palomar Medical Technologies, Inc | Method and apparatus for fractional deformation and treatment of cutaneous and subcutaneous tissue |
EA018602B1 (en) | 2008-08-25 | 2013-09-30 | Лазер Абразив Техноложес, Ллс | Method and apparatus for regeneration of oral cavity tissues |
US20100109041A1 (en) | 2008-11-06 | 2010-05-06 | Chun-Chiang Yin | High efficiency led structure |
US8410705B2 (en) | 2008-11-18 | 2013-04-02 | Ringdale, Inc. | LED lighting system with bypass circuit for failed LED |
US20130096546A1 (en) | 2009-03-05 | 2013-04-18 | Cynosure, Inc. | Non-uniform beam optical treatment methods and systems |
WO2010115209A2 (en) | 2009-04-03 | 2010-10-07 | Palomar Medical Technologies, Inc. | Method and apparatus for treatment of tissue |
US20100298744A1 (en) | 2009-04-30 | 2010-11-25 | Palomar Medical Technologies, Inc. | System and method of treating tissue with ultrasound energy |
JP5412979B2 (en) | 2009-06-19 | 2014-02-12 | コニカミノルタ株式会社 | Peripheral display device |
US9919168B2 (en) | 2009-07-23 | 2018-03-20 | Palomar Medical Technologies, Inc. | Method for improvement of cellulite appearance |
US20120116271A1 (en) | 2009-07-23 | 2012-05-10 | Palomar Medical Technologies, Inc. | Cellulite treatment |
US9014799B2 (en) | 2009-10-08 | 2015-04-21 | Palo Alto Research Center Incorporated | Transmucosal drug delivery device and method including electrically-actuated permeation enhancement |
US8956343B2 (en) | 2009-12-31 | 2015-02-17 | Laser Abrasive Technologies, Llc | Dental surgical laser with feedback mechanisms |
JP5820397B2 (en) * | 2010-01-27 | 2015-11-24 | ヘレウス ノーブルライト アメリカ エルエルシー | Microchannel cooling type high heat load light emitting device |
US20110257584A1 (en) | 2010-04-16 | 2011-10-20 | Palomar Medical Technologies, Inc. | Methods and devices for injection of a substance into tissue |
US20120099816A1 (en) | 2010-10-25 | 2012-04-26 | Palomar Medical Technologies, Inc. | Photonics module and method of manufacturing |
US20120277659A1 (en) | 2011-04-29 | 2012-11-01 | Palomar Medical Technologies, Inc. | Sensor-lotion system for use with body treatment devices |
CN104114115B (en) | 2011-10-17 | 2017-02-22 | 声外科技术有限公司 | ultrasonic probe for treating cellulite |
EP2711676B1 (en) | 2012-09-20 | 2020-10-07 | VascoMed GmbH | Fiber-optic force sensor, force measurement device and catheter |
-
2003
- 2003-06-19 BR BR0312430-4A patent/BR0312430A/en not_active Application Discontinuation
- 2003-06-19 AU AU2003245573A patent/AU2003245573A1/en not_active Abandoned
- 2003-06-19 CA CA002489506A patent/CA2489506A1/en not_active Abandoned
- 2003-06-19 EP EP03739201A patent/EP1539013A4/en not_active Withdrawn
- 2003-06-19 US US10/465,757 patent/US7276058B2/en not_active Expired - Lifetime
- 2003-06-19 CN CNB038198444A patent/CN1329008C/en not_active Expired - Fee Related
- 2003-06-19 KR KR1020047020627A patent/KR20050026404A/en not_active Application Discontinuation
- 2003-06-19 JP JP2004515915A patent/JP2005535370A/en active Pending
- 2003-06-19 WO PCT/US2003/019280 patent/WO2004000098A2/en not_active Application Discontinuation
-
2004
- 2004-12-12 IL IL16572404A patent/IL165724A0/en unknown
-
2007
- 2007-10-01 US US11/865,367 patent/US20080103565A1/en not_active Abandoned
-
2008
- 2008-02-15 US US12/032,004 patent/US8915948B2/en not_active Expired - Lifetime
-
2015
- 2015-01-02 US US14/588,746 patent/US20150165232A1/en not_active Abandoned
-
2017
- 2017-01-10 US US15/402,649 patent/US10556123B2/en not_active Expired - Fee Related
- 2017-01-10 US US15/402,693 patent/US10500413B2/en not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
BR0312430A (en) | 2005-04-26 |
EP1539013A4 (en) | 2005-09-21 |
WO2004000098A2 (en) | 2003-12-31 |
US20150165232A1 (en) | 2015-06-18 |
US10556123B2 (en) | 2020-02-11 |
CN1329008C (en) | 2007-08-01 |
US7276058B2 (en) | 2007-10-02 |
WO2004000098A3 (en) | 2004-05-13 |
US20170182335A1 (en) | 2017-06-29 |
US10500413B2 (en) | 2019-12-10 |
US20080103565A1 (en) | 2008-05-01 |
US20090024193A1 (en) | 2009-01-22 |
US20040073079A1 (en) | 2004-04-15 |
US8915948B2 (en) | 2014-12-23 |
EP1539013A2 (en) | 2005-06-15 |
JP2005535370A (en) | 2005-11-24 |
AU2003245573A1 (en) | 2004-01-06 |
US20170182334A1 (en) | 2017-06-29 |
IL165724A0 (en) | 2006-01-15 |
CN1674837A (en) | 2005-09-28 |
KR20050026404A (en) | 2005-03-15 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
US10500413B2 (en) | Method and apparatus for treatment of cutaneous and subcutaneous conditions | |
US11607556B2 (en) | Aesthetic method of biological structure treatment by magnetic field | |
US11253718B2 (en) | High power time varying magnetic field therapy | |
US7351252B2 (en) | Method and apparatus for photothermal treatment of tissue at depth | |
US20160220834A1 (en) | Method and system for skin treatment | |
US20170106201A1 (en) | Combination of magnetic and electromagnetic treatment method | |
KR101577156B1 (en) | Systems for subcutaneous treatments | |
US9072521B2 (en) | Non-invasive device for treating body tissue | |
US20120029394A1 (en) | Ultrasound Assisted Laser Skin and Tissue Treatment | |
Murgia et al. | Body contouring for fat and muscle in aesthetics: review and debate | |
Narsete et al. | Evaluation of radiofrequency devices in aesthetic medicine: a preliminary report | |
KR20050024353A (en) | Method and apparatus for treatment of cutaneous and subcutaneous conditions | |
KR200239886Y1 (en) | Heat and Super Long Wave Medical Treatment Apparatus | |
Kim et al. | 3 Approach to cellulite and fat |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
EEER | Examination request | ||
FZDE | Discontinued |