CA2481511A1 - Blood component processing system, apparatus, and method - Google Patents
Blood component processing system, apparatus, and method Download PDFInfo
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- CA2481511A1 CA2481511A1 CA002481511A CA2481511A CA2481511A1 CA 2481511 A1 CA2481511 A1 CA 2481511A1 CA 002481511 A CA002481511 A CA 002481511A CA 2481511 A CA2481511 A CA 2481511A CA 2481511 A1 CA2481511 A1 CA 2481511A1
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B04—CENTRIFUGAL APPARATUS OR MACHINES FOR CARRYING-OUT PHYSICAL OR CHEMICAL PROCESSES
- B04B—CENTRIFUGES
- B04B13/00—Control arrangements specially designed for centrifuges; Programme control of centrifuges
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
- A61M1/02—Blood transfusion apparatus
- A61M1/0209—Multiple bag systems for separating or storing blood components
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
- A61M1/02—Blood transfusion apparatus
- A61M1/0209—Multiple bag systems for separating or storing blood components
- A61M1/0218—Multiple bag systems for separating or storing blood components with filters
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
- A61M1/02—Blood transfusion apparatus
- A61M1/025—Means for agitating or shaking blood containers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
- A61M1/14—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis
- A61M1/16—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis with membranes
- A61M1/26—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis with membranes and internal elements which are moving
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
- A61M1/14—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis
- A61M1/16—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis with membranes
- A61M1/26—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis with membranes and internal elements which are moving
- A61M1/262—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis with membranes and internal elements which are moving rotating
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
- A61M1/36—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits
- A61M1/3621—Extra-corporeal blood circuits
- A61M1/3639—Blood pressure control, pressure transducers specially adapted therefor
- A61M1/3641—Pressure isolators
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- A—HUMAN NECESSITIES
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- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
- A61M1/36—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits
- A61M1/3693—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits using separation based on different densities of components, e.g. centrifuging
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
- A61M1/36—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits
- A61M1/3693—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits using separation based on different densities of components, e.g. centrifuging
- A61M1/3696—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits using separation based on different densities of components, e.g. centrifuging with means for adding or withdrawing liquid substances during the centrifugation, e.g. continuous centrifugation
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
- A61M1/36—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits
- A61M1/3693—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits using separation based on different densities of components, e.g. centrifuging
- A61M1/3698—Expressing processed fluid out from the turning rotor using another fluid compressing the treatment chamber; Variable volume rotors
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B04—CENTRIFUGAL APPARATUS OR MACHINES FOR CARRYING-OUT PHYSICAL OR CHEMICAL PROCESSES
- B04B—CENTRIFUGES
- B04B5/00—Other centrifuges
- B04B5/04—Radial chamber apparatus for separating predominantly liquid mixtures, e.g. butyrometers
- B04B5/0407—Radial chamber apparatus for separating predominantly liquid mixtures, e.g. butyrometers for liquids contained in receptacles
- B04B5/0428—Radial chamber apparatus for separating predominantly liquid mixtures, e.g. butyrometers for liquids contained in receptacles with flexible receptacles
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B04—CENTRIFUGAL APPARATUS OR MACHINES FOR CARRYING-OUT PHYSICAL OR CHEMICAL PROCESSES
- B04B—CENTRIFUGES
- B04B5/00—Other centrifuges
- B04B5/04—Radial chamber apparatus for separating predominantly liquid mixtures, e.g. butyrometers
- B04B5/0442—Radial chamber apparatus for separating predominantly liquid mixtures, e.g. butyrometers with means for adding or withdrawing liquid substances during the centrifugation, e.g. continuous centrifugation
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
- A61M1/36—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits
- A61M1/3621—Extra-corporeal blood circuits
- A61M1/3627—Degassing devices; Buffer reservoirs; Drip chambers; Blood filters
- A61M1/3633—Blood component filters, e.g. leukocyte filters
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
- A61M1/36—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits
- A61M1/3621—Extra-corporeal blood circuits
- A61M1/3639—Blood pressure control, pressure transducers specially adapted therefor
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2205/00—General characteristics of the apparatus
- A61M2205/33—Controlling, regulating or measuring
- A61M2205/3306—Optical measuring means
- A61M2205/331—Optical measuring means used as turbidity change detectors, e.g. for priming-blood or plasma-hemoglubine-interface detection
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B04—CENTRIFUGAL APPARATUS OR MACHINES FOR CARRYING-OUT PHYSICAL OR CHEMICAL PROCESSES
- B04B—CENTRIFUGES
- B04B5/00—Other centrifuges
- B04B5/04—Radial chamber apparatus for separating predominantly liquid mixtures, e.g. butyrometers
- B04B5/0442—Radial chamber apparatus for separating predominantly liquid mixtures, e.g. butyrometers with means for adding or withdrawing liquid substances during the centrifugation, e.g. continuous centrifugation
- B04B2005/045—Radial chamber apparatus for separating predominantly liquid mixtures, e.g. butyrometers with means for adding or withdrawing liquid substances during the centrifugation, e.g. continuous centrifugation having annular separation channels
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B04—CENTRIFUGAL APPARATUS OR MACHINES FOR CARRYING-OUT PHYSICAL OR CHEMICAL PROCESSES
- B04B—CENTRIFUGES
- B04B5/00—Other centrifuges
- B04B5/04—Radial chamber apparatus for separating predominantly liquid mixtures, e.g. butyrometers
- B04B5/0442—Radial chamber apparatus for separating predominantly liquid mixtures, e.g. butyrometers with means for adding or withdrawing liquid substances during the centrifugation, e.g. continuous centrifugation
- B04B2005/0478—Radial chamber apparatus for separating predominantly liquid mixtures, e.g. butyrometers with means for adding or withdrawing liquid substances during the centrifugation, e.g. continuous centrifugation with filters in the separation chamber
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B04—CENTRIFUGAL APPARATUS OR MACHINES FOR CARRYING-OUT PHYSICAL OR CHEMICAL PROCESSES
- B04B—CENTRIFUGES
- B04B13/00—Control arrangements specially designed for centrifuges; Programme control of centrifuges
- B04B2013/006—Interface detection or monitoring of separated components
Abstract
A system and method are used in connection with processing of blood components. The processing of blood components may involve centrifugal separation and/or filtering of the blood components. In some examples, at least some blood components are centrifugally separated in a chamber and then filtered via a filter (31) rotating along with a centrifuge rotor (1), wherein the filter is located closer than the chamber to an axis of rotation of the rotor. The filter may include a porous filtration medium configured to filter leukocytes, platelets, and/or red blood cells. Some examples include a pressure sensor sensing pressure of pumped blood components. The sensed pressure may be used in connection with controlling the pumping of the blood products and/or in connection with determining the location of an interface associated with the blood products. Other uses of the sensed pressure are also possible.
Claims (163)
1. A system for processing blood components, the system comprising:
a separation chamber comprising a chamber interior in which blood components are centrifugally separated, and an outlet port for passing at least some of the centrifugally separated blood components from the chamber interior;
a flow path in flow communication with the outlet port of the separation chamber;
a filter comprising a filter inlet in flow communication with the flow path, a porous filtration medium configured to filter at least some of at least one blood component from centrifugally separated blood components passed to the filter via the flow path, and a filter outlet for filtered blood components; and a centrifuge rotor configured to be rotated about an axis of rotation, the rotor comprising a first portion configured to receive the separation chamber and a second portion configured to receive the filter, wherein the first and second portions are positioned with respect to one another so that when the separation chamber is received in the first portion and the filter is received in the second portion, the filter is closer than the interior of the separation chamber to the axis of rotation, wherein the system is configured so that the rotor rotates during filtering of at least some of said at least one blood component via the filter.
a separation chamber comprising a chamber interior in which blood components are centrifugally separated, and an outlet port for passing at least some of the centrifugally separated blood components from the chamber interior;
a flow path in flow communication with the outlet port of the separation chamber;
a filter comprising a filter inlet in flow communication with the flow path, a porous filtration medium configured to filter at least some of at least one blood component from centrifugally separated blood components passed to the filter via the flow path, and a filter outlet for filtered blood components; and a centrifuge rotor configured to be rotated about an axis of rotation, the rotor comprising a first portion configured to receive the separation chamber and a second portion configured to receive the filter, wherein the first and second portions are positioned with respect to one another so that when the separation chamber is received in the first portion and the filter is received in the second portion, the filter is closer than the interior of the separation chamber to the axis of rotation, wherein the system is configured so that the rotor rotates during filtering of at least some of said at least one blood component via the filter.
2. The system of claim 1, wherein the system is configured so that when the filter is received in the second portion, the filter is eccentric with respect to the axis of rotation.
3. The system of claim 2, wherein the system is configured so that when the filter is received in the second portion, the filter is at least close to the axis of rotation and wherein the axis of rotation does not intersect an interior flow path defined by the filter.
4. The system of claim 2, wherein the filter comprises a filter housing inflow port and a filter housing outflow port, and wherein the system is configured so that when the filter is received in the second portion, the filter housing outflow port is located closer than the filter housing inflow port to the axis of rotation.
5. The system of claim 2, wherein the system is configured so that when the filter is received in the second portion, the filter housing outflow port is closer than the porous filtration medium to the axis of rotation.
6. The system of claim 2, wherein the system is configured so that when the filter is received in the second portion, the filter housing outflow port is above the filter housing inflow port.
7. The system of claim 2, wherein the filter comprises a filter housing defining an interior space containing the porous filtration medium, wherein the filter inlet and filter outlet are in flow communication with the interior space, and wherein the system is configured so that when the filter is received in the second portion, the filter is positioned so that blood components flow in the interior space in a direction facing generally toward the axis of rotation.
8. The system of claim 7, wherein the filter housing defines a filter housing inflow port for passing blood components to the interior space and a filter housing outflow port for passing blood components from the interior space, and wherein the system is configured so that when the filter is received in the second portion, the filter housing outflow port is closer than the filter housing inflow port to the axis of rotation.
9. The system of claim 7, wherein the filter housing defines a filter housing inflow port for passing blood components to the interior space and a filter housing outflow port for passing blood components from the interior space, and wherein the system is configured so that when the filter is received in the second portion, the filter housing outflow port is closer than the porous filtration medium to the axis of rotation.
10. The system of claim 7, wherein the filter housing defines a filter housing inflow port for passing blood components to the interior space and a filter housing outflow port for passing blood components from the interior space, and wherein the system is configured so that when the filter is received in the second portion, the filter housing outflow port is above the filter housing inflow port.
11. The system of claim 1, wherein the second portion comprises at least one of a ledge and a slot configured to receive the filter, the at least one of a ledge and a slot being positioned under a top surface of the rotor.
12. The system of claim 1, wherein the rotor comprises a holder configured to hold the filter with respect to the rotor.
13. The system of claim 1, wherein the flow path comprises a first tubing portion having one end coupled to the outlet port of the separation chamber and another end coupled to the filter inlet, and wherein the system further comprises a second tubing portion having an end coupled to the filter outlet, wherein the second tubing portion extends in a direction facing generally away from the axis of rotation.
14. The system of claim 13, further comprising a third tubing portion downstream from the second tubing portion, wherein the third tubing portion extends in a direction facing generally toward the axis of rotation.
15. The system of claim 14, wherein the rotor comprises a groove configured to receive at least some of the second and third tubing portions.
16. The system of claim 1, wherein the system further comprises a collection container comprising an inlet in flow communication with the filter outlet, and wherein the second portion of the rotor comprises a cavity configured to receive the filter and the collection container.
17. The system of claim 1, wherein the axis of rotation extends through the second portion of the rotor.
18. The system of claim 1, wherein the chamber is configured so that the chamber interior has a variable volume.
19. The system of claim 1, wherein the separation chamber comprises a blood component separation bag.
20. The system of claim 19, wherein at least a portion of the blood component separation bag is formed of at least one of flexible and semi-rigid material so that the chamber interior has a variable volume.
21. The system of claim 19, wherein the bag has a generally annular ring shape defining a central opening.
22. The system of claim 19, wherein the chamber interior includes a tapered portion leading to the outlet port.
23. The system of claim 1, wherein the system comprises a tubing line having an end coupled to the filter outlet, and wherein the rotor comprises at least one support member configured to support the separation chamber, wherein the at least one support member comprises a guide groove configured to receive a portion of the tubing line and at least one of a controllable clamp and a welder associated with the groove.
24. The system of claim 23, wherein the separation chamber comprises at least one guide hole configured to receive the at least one support member.
25. The system of claim 1, wherein the rotor comprises a plurality of support members located in an asymmetric fashion with respect to the axis of rotation, and wherein the separation chamber comprises a plurality of guide holes, each of the guide holes being configured to receive a respective one of the support members.
26. The system of claim 1, wherein the separation chamber has a ring shape.
27. The system of claim 1, further comprising at least one valuing member on the centrifuge rotor, the valuing member being configured to control flow of at least some of the blood components during rotation of the rotor.
28. The system of claim 27, wherein the valuing member comprises a tubing clamp.
29. The system of claim 1, further comprising at least one sealing member on the centrifuge rotor, the sealing member being configured to create a seal during rotation of the rotor.
30. The system of claim 29, wherein the sealing member comprises a tubing welder.
31. The system of claim 1, further comprising a pump configured to pump at least some of the centrifugally separated blood components from the chamber to the filter via the flow path.
32. The system of claim 31, wherein the system is configured so that the pump pumps blood components from the chamber during rotation of the centrifuge rotor.
33. The system of claim 31, wherein the chamber is configured so that the chamber interior has a variable volume, and wherein the pump is configured to reduce the volume of the chamber interior.
34. The system of claim 33, wherein the pump is configured to apply pressure to the chamber via hydraulic fluid.
35. The system of claim 34, further comprising a sensor configured to sense pressure of pumped blood components, wherein the sensor senses pressure of the hydraulic fluid.
36. The system of claim 31, further comprising a sensor configured to sense pressure of pumped blood components, wherein the system is configured to control the pump based on at least the pressure sensed by the pressure sensor.
37. The system of claim 36, wherein the system is configured to calculate a difference between pressures sensed by the pressure sensor in at least one time interval, determine when the calculated difference is at least a predetermined amount, and control the pump in response to at least the determination that the calculated difference is at least the predetermined amount.
38. The system of claim 36, further comprising an optical sensor, wherein the system is configured to control the pump based on at least information sensed by the optical sensor and pressure sensed by the pressure sensor.
39. A method of processing blood components, comprising:
providing the system of claim 1;
placing the separation chamber in the first portion of the rotor and the filter in the second portion of the rotor, wherein the filter is located closer than an interior of the separation chamber to the axis of rotation of the rotor;
rotating the centrifuge rotor, the separation chamber, and the filter about the axis of rotation of the centrifuge rotor, wherein blood components are centrifugally separated in the chamber interior;
removing at least some of the centrifugally separated blood components from the separation chamber via the outlet port; and filtering the removed blood components with the filter so as to filter at least some of at least one blood component from the removed blood components, wherein at least a portion of the filtering occurs during said rotating.
providing the system of claim 1;
placing the separation chamber in the first portion of the rotor and the filter in the second portion of the rotor, wherein the filter is located closer than an interior of the separation chamber to the axis of rotation of the rotor;
rotating the centrifuge rotor, the separation chamber, and the filter about the axis of rotation of the centrifuge rotor, wherein blood components are centrifugally separated in the chamber interior;
removing at least some of the centrifugally separated blood components from the separation chamber via the outlet port; and filtering the removed blood components with the filter so as to filter at least some of at least one blood component from the removed blood components, wherein at least a portion of the filtering occurs during said rotating.
40. A method of processing blood components, comprising:
placing a separation chamber in a first portion of a centrifuge rotor and a filter in a second portion of the rotor, wherein the filter is located closer than an interior of the separation chamber to an axis of rotation of the centrifuge rotor, and wherein the filter comprises a porous filtration medium;
rotating the centrifuge rotor, the separation chamber, and the filter about the axis of rotation, wherein blood components are centrifugally separated in a chamber interior of the separation chamber;
removing at least some of the centrifugally separated blood components from the separation chamber via an outlet port of the separation chamber; and filtering the removed blood components with the filter so as to filter at least some of at least one blood component from the removed blood components, wherein at least a portion of the filtering occurs during said rotating.
placing a separation chamber in a first portion of a centrifuge rotor and a filter in a second portion of the rotor, wherein the filter is located closer than an interior of the separation chamber to an axis of rotation of the centrifuge rotor, and wherein the filter comprises a porous filtration medium;
rotating the centrifuge rotor, the separation chamber, and the filter about the axis of rotation, wherein blood components are centrifugally separated in a chamber interior of the separation chamber;
removing at least some of the centrifugally separated blood components from the separation chamber via an outlet port of the separation chamber; and filtering the removed blood components with the filter so as to filter at least some of at least one blood component from the removed blood components, wherein at least a portion of the filtering occurs during said rotating.
41. The method of claim 40, wherein the method further comprises passing the filtered blood components into at least one collection container.
42. The method of claim 40, wherein the blood components in the separation chamber are blood components of a buffy coat.
43. The method of claim 40, wherein whole blood is processed in the method.
44. The method of claim 40, wherein the filter comprises a filter housing defining an interior space containing the porous filtration medium, and wherein the method comprises flowing blood components in the interior space in a direction facing generally toward the axis of rotation.
45. The method of claim 40, further comprising causing at least one valuing member on the centrifuge rotor to control flow of at least some of the blood components during rotation of the rotor.
46. The method of claim 45, wherein the valuing member comprises a tubing clamp.
47. The method of claim 40, further comprising causing at least one sealing member on the centrifuge rotor to create a seal during rotation of the rotor.
48. The method of claim 47, wherein the sealing member comprises a tubing welder.
49. The method of claim 40, further comprising pumping at least some of the centrifugally separated blood components from the chamber to the filter.
50. The method of claim 49, wherein the pumping occurs during rotation of the centrifuge rotor.
51. The method of claim 49, wherein the pumping comprises reducing the volume of an interior of the chamber.
52. The method of claim 51, further comprising applying pressure to the chamber via hydraulic fluid.
53. The method of claim 49, further comprising sensing pressure of pumped blood components, and controlling the pumping based on at least the sensed pressure.
54. The method of claim 53, further comprising calculating a difference between pressures sensed in at least one time interval, determining when the calculated difference is at least a predetermined amount, and controlling the pumping in response to at least the determination that the calculated difference is at least the predetermined amount.
55. The method of claim 53, further comprising optically sensing the pumped blood products, and controlling the pumping based on at least one of optically sensed information and sensed pressure.
56. An apparatus for use with a centrifuge for processing blood components, the apparatus comprising:
a separation chamber comprising a chamber interior in which blood components are centrifugally separated, and an outlet port for passing at least some of the centrifugally separated blood components from the chamber interior;
a flow path in flow communication with the outlet port of the separation chamber; and a filter comprising a filter inlet in flow communication with the flow path, a porous filtration medium configured to filter at least some of at least one blood component from centrifugally separated blood components passed to the filter via the flow path, and a filter outlet for filtered blood components, wherein the centrifuge for use with the apparatus comprises a rotor configured to be rotated about an axis of rotation, the rotor comprising a first portion configured to receive the separation chamber and a second portion configured to receive the filter, wherein the first and second portions are positioned with respect to one another so that when the separation chamber is received in the first portion and the filter is received in the second portion, the filter is closer than the interior of the separation chamber to the axis of rotation, and wherein the centrifuge is configured so'that the rotor rotates during filtering of at least some of said at least one blood component via the filter.
a separation chamber comprising a chamber interior in which blood components are centrifugally separated, and an outlet port for passing at least some of the centrifugally separated blood components from the chamber interior;
a flow path in flow communication with the outlet port of the separation chamber; and a filter comprising a filter inlet in flow communication with the flow path, a porous filtration medium configured to filter at least some of at least one blood component from centrifugally separated blood components passed to the filter via the flow path, and a filter outlet for filtered blood components, wherein the centrifuge for use with the apparatus comprises a rotor configured to be rotated about an axis of rotation, the rotor comprising a first portion configured to receive the separation chamber and a second portion configured to receive the filter, wherein the first and second portions are positioned with respect to one another so that when the separation chamber is received in the first portion and the filter is received in the second portion, the filter is closer than the interior of the separation chamber to the axis of rotation, and wherein the centrifuge is configured so'that the rotor rotates during filtering of at least some of said at least one blood component via the filter.
57. The apparatus of claim 56, wherein the apparatus further comprises a collection container comprising an inlet in flow communication with the filter outlet, and wherein the second portion of the rotor comprises a cavity configured to receive the filter and the collection container.
58. The system of claim 56, wherein the chamber is configured so that the chamber interior has a variable volume.
59. The apparatus of claim 56, wherein the separation chamber comprises a blood component separation bag.
60. The apparatus of claim 59, wherein at least a portion of the blood component separation bag is formed of at least one of flexible and semi-rigid material so that the chamber interior has a variable volume.
61. The apparatus of claim 59, wherein the bag has a generally annular ring shape defining a central opening.
62. The apparatus of claim 59, wherein the chamber interior includes a tapered portion leading to the outlet port.
63. The apparatus of claim 56, wherein the separation chamber comprises at least one guide hole configured to receive at least one support member of the centrifuge.
64. The apparatus of claim 56, wherein the rotor comprises a plurality of support members located in an asymmetric fashion with respect to the axis of rotation, and wherein the separation chamber comprises a plurality of guide holes, each of the guide holes being configured to receive a respective one of the support members.
65. The apparatus of claim 56, wherein the apparatus is configured to be disposed after being used for processing of blood components from a single donor.
66. The apparatus of claim 56, wherein the separation chamber has a ring shape.
67. A system for processing blood components, comprising:
a chamber comprising an interior configured to contain separated blood components, and an outlet port for passing at least some of the separated blood components from the interior;
a flow path in flow communication with the outlet port of the chamber;
a filter comprising a filter inlet in flow communication with the flow path, a porous filtration medium configured to filter at least some of at least one blood component from separated blood components passed to the filter via the flow path, and a filter outlet for filtered blood components;
a pump configured to pump at least some of the separated blood components from the chamber to the filter via the flow path; and a pressure sensor configured to sense pressure of blood components pumped to the filter, wherein the system is configured to control the pump based on at least the pressure sensed by the pressure sensor.
a chamber comprising an interior configured to contain separated blood components, and an outlet port for passing at least some of the separated blood components from the interior;
a flow path in flow communication with the outlet port of the chamber;
a filter comprising a filter inlet in flow communication with the flow path, a porous filtration medium configured to filter at least some of at least one blood component from separated blood components passed to the filter via the flow path, and a filter outlet for filtered blood components;
a pump configured to pump at least some of the separated blood components from the chamber to the filter via the flow path; and a pressure sensor configured to sense pressure of blood components pumped to the filter, wherein the system is configured to control the pump based on at least the pressure sensed by the pressure sensor.
61 63. The system of claim 67, wherein the pump comprises a portion of a centrifuge.
69. The system of claim 67, wherein the pump comprises at least a portion of a blood component expressor.
70. The system of claim 67, wherein the chamber comprises a separation chamber, wherein blood components are centrifugally separated in the interior of the container, and wherein the system further comprises a centrifuge rotor configured to be rotated about an axis of rotation, the rotor comprising a portion configured to receive the chamber.
71. The system of claim 70, wherein the system is configured so that the pump pumps blood components from the chamber during rotation of the centrifuge rotor.
72. The system of claim 70, further comprising at least one valving member on the centrifuge rotor, the valving member being configured to control flow of at least some of the blood components during rotation of the rotor.
73. The system of claim 72, wherein the valving member comprises a tubing clamp.
74. The system of claim 70, further comprising at least one sealing member on the centrifuge rotor, the sealing member being configured to create a seal during rotation of the rotor.
75. The system of claim 74, wherein the sealing member comprises a tubing welder.
76. The system of claim 70, wherein the rotor further comprises a portion configured to receive the filter, and wherein the system is configured so that the rotor rotates during filtering via the filter.
77. The system of claim 76, wherein the filter comprises a filter housing defining an interior space containing the porous filtration medium, wherein the system is configured so that when the filter is received in the portion of the rotor configured to receive the filter, the filter is positioned so that blood components flow in the interior space in a direction facing generally toward the axis of rotation.
78. The system of claim 67, wherein the chamber comprises a bag formed of at least one of flexible and semi-rigid material so that the interior of the chamber has a variable volume.
79. The system of claim 78, wherein the bag has a generally annular shape defining a central opening.
80. The system of claim 67, wherein the chamber is configured so that the interior of the chamber has a variable volume.
81. The system of claim 80, wherein the pump is configured to reduce the volume of the chamber interior.
82. The system of claim 81, wherein the pump is configured to apply pressure to the chamber via hydraulic fluid.
83. The system of claim 82, wherein the sensor senses pressure of the hydraulic fluid.
84. The system of claim 67, wherein the system is configured to calculate a difference between pressures sensed by the pressure sensor in at least one time interval where blood components are pumped by the pump, determine when the calculated difference is at least a predetermined amount, and control the pump in response to at least the determination that the calculated difference is at least the predetermined amount.
85. The system of claim 67, further comprising an optical sensor, wherein the system is configured to control the pump based on at least information sensed by the optical sensor and pressure sensed by the pressure sensor.
86. The system of claim 85, wherein said optical sensor is positioned to sense blood components in the chamber.
87. The system of claim 85, wherein said optical sensor is positioned to sense blood components in a tubing line in flow communication with the filter.
88. The system of claim 85, wherein said optical sensor comprises a first optical sensor and a second optical sensor, the first optical sensor being positioned to sense blood components in the chamber and the second optical sensor being positioned to sense blood components in a tubing line in flow communication with the filter.
89. A method of processing blood components, comprising:
providing the system of claim 67;
pumping, via the pump, at least some of the separated blood components from the chamber;
filtering the pumped blood components with the filter so as to filter at least some of at least one blood component from the pumped blood components;
sensing, via the pressure sensor, pressure of blood components pumped to the filter; and controlling the pumping based on at least the pressure sensed by the pressure sensor.
providing the system of claim 67;
pumping, via the pump, at least some of the separated blood components from the chamber;
filtering the pumped blood components with the filter so as to filter at least some of at least one blood component from the pumped blood components;
sensing, via the pressure sensor, pressure of blood components pumped to the filter; and controlling the pumping based on at least the pressure sensed by the pressure sensor.
90. A method of processing blood components, comprising:
pumping at least some separated blood components from a chamber;
filtering the pumped blood components with a filter so as to filter at least some of at least one blood component from the pumped blood components, wherein the filter comprises a porous filtration membrane;
sensing pressure of blood components pumped to the filter; and controlling the pumping based on at least the pressure sensed by the pressure sensor.
pumping at least some separated blood components from a chamber;
filtering the pumped blood components with a filter so as to filter at least some of at least one blood component from the pumped blood components, wherein the filter comprises a porous filtration membrane;
sensing pressure of blood components pumped to the filter; and controlling the pumping based on at least the pressure sensed by the pressure sensor.
91. The method of claim 90, further comprising rotating the chamber about an axis of rotation, wherein blood components are centrifugally separated in an interior of the chamber.
92. The method of claim 91, wherein the pumping occurs during rotation of the chamber.
93. The method of claim 91, wherein a centrifuge is used to rotate the chamber, and wherein said at least some separated blood components are pumped from the chamber while the chamber is received on a rotor of the centrifuge.
94. The method of claim 93, further comprising causing at least one valuing member on the centrifuge rotor to control flow of at least some of the blood components during rotation of the rotor.
95. The method of claim 94, wherein the valuing member comprises a tubing clamp.
96. The method of claim 93, further comprising causing at least one sealing member on the centrifuge rotor to create a seal during rotation of the rotor.
97. The method of claim 96, wherein the sealing member comprises a tubing welder.
98. The method of claim 91, wherein a centrifuge is used to rotate the chamber, and wherein said at least some separated blood components are pumped from the chamber after the chamber is removed from a rotor of the centrifuge.
99. The method of claim 90, further comprising rotating the filter about an axis of rotation during the filtering.
100. The method of claim 99, wherein the filter comprises a filter housing defining an interior space containing the porous filtration medium, and wherein the method comprises flowing blood components in the interior space in a direction facing generally toward the axis of rotation.
101. The method of claim 90, wherein the chamber is configured so that an interior of the chamber has a variable volume, and wherein the pumping comprises reducing the volume of the interior of the chamber.
102. The method of claim 101, further comprising applying pressure to the chamber via hydraulic fluid.
103. The method of claim 90, further comprising calculating a difference between pressures sensed in at least one time interval, determining when the calculated difference is at least a predetermined amount, and controlling the pumping in response to at least the determination that the calculated difference is at least the predetermined amount.
104. The method of claim 90, further comprising optically sensing the pumped blood products, and controlling the pumping based on at least one of optically sensed information and sensed pressure.
105. The method of claim 104, wherein optically sensing comprises optically sensing blood components in the chamber.
106. The method of claim 104, wherein optically sensing comprises optically sensing blood components in a tubing line in flow communication with the filter.
107. The method of claim 104, wherein optically sensing comprises optically sensing blood components in the chamber and optically sensing blood components in a tubing line in flow communication with the filter.
108. The method of claim 90, wherein the method further comprises passing the filtered blood components into at least one collection container.
109. The method of claim 90, wherein the blood components in the chamber are blood components of a buffy coat.
110. The method of claim 90, wherein whole blood is processed in the method.
111. A system for processing blood components, comprising:
a separation chamber comprising a chamber interior in which blood components are centrifugally separated, and an outlet port for passing at least some of the centrifugally separated blood components from the chamber interior;
a flow path in flow communication with the outlet port of the separation chamber; a pump configured to pump at least some of the centrifugally separated blood components from the chamber and through the flow path; and a pressure sensor configured to sense pressure of blood components pumped by the pump; and a centrifuge rotor configured to be rotated about an axis of rotation, the rotor comprising a portion configured to receive the separation chamber, wherein the system is configured to calculate a difference between pressures sensed by the pressure sensor in at least one time interval, determine when the calculated difference is at least a predetermined amount, and control the pump in response to at least the determination that the calculated difference is at least the predetermined amount.
a separation chamber comprising a chamber interior in which blood components are centrifugally separated, and an outlet port for passing at least some of the centrifugally separated blood components from the chamber interior;
a flow path in flow communication with the outlet port of the separation chamber; a pump configured to pump at least some of the centrifugally separated blood components from the chamber and through the flow path; and a pressure sensor configured to sense pressure of blood components pumped by the pump; and a centrifuge rotor configured to be rotated about an axis of rotation, the rotor comprising a portion configured to receive the separation chamber, wherein the system is configured to calculate a difference between pressures sensed by the pressure sensor in at least one time interval, determine when the calculated difference is at least a predetermined amount, and control the pump in response to at least the determination that the calculated difference is at least the predetermined amount.
112. The system of claim 111, wherein the system is configured so that the pump pumps blood components from the chamber during rotation of the centrifuge rotor.
113. The system of claim 111, further comprising at least one valving member on the centrifuge rotor, the valving member being configured to control flow of at least some of the blood components during rotation of the rotor.
114. The system of claim 113, wherein the valving member comprises a tubing clamp.
115. The system of claim 111, further comprising a sealing member on the centrifuge rotor, the sealing member being configured to create a seal during rotation of the rotor.
116. The system of claim 115, wherein the sealing member comprises a tubing welder.
117. The system of claim 111, further comprising a filter comprising a porous filtration membrane configured to filter at least one blood component from the pumped blood products.
118. The system of claim 111, wherein the chamber comprises a bag formed of at least one of flexible and semi-rigid material so that the interior of the chamber has a variable volume.
119. The system of claim 118, wherein the bag has a generally annular shape defining a central opening.
120. The system of claim 111, wherein the chamber is configured so that the chamber interior has a variable volume,
121. The system of claim 120, wherein the pump is configured to reduce the volume of the chamber interior.
122. The system of claim 121, wherein the pump is configured to apply pressure to the chamber via hydraulic fluid.
123. The system of claim 122, wherein the sensor senses pressure of the hydraulic fluid.
124. The system of claim 111, further comprising an optical sensor, wherein the system is configured to control the pump based on at least information sensed by the optical sensor and pressure sensed by the pressure sensor.
125. The system of claim 124, wherein said optical sensor is positioned to sense blood components in the chamber.
126. The system of claim 124, wherein said optical sensor is positioned to sense blood components in a tubing line in flow communication with the filter.
127. The system of claim 124, wherein said optical sensor comprises a first optical sensor and a second optical sensor, the first optical sensor being positioned to sense blood components in the chamber and the second optical sensor being positioned to sense blood components in a tubing line associated with the flow path.
128. A method of processing blood components, comprising:
providing the system of claim 111;
rotating the centrifuge rotor and the chamber about the axis of rotation, wherein blood components are centrifugally separated in the chamber;
pumping, via the pump, at least some separated blood components from the chamber;
sensing, via the pressure sensor, pressure of pumped blood components;
calculating a difference between pressures sensed in at least one time interval;
determining when the calculated difference is at least a predetermined amount; and controlling the pumping in response to at least the determination that the calculated difference is at least the predetermined amount.
providing the system of claim 111;
rotating the centrifuge rotor and the chamber about the axis of rotation, wherein blood components are centrifugally separated in the chamber;
pumping, via the pump, at least some separated blood components from the chamber;
sensing, via the pressure sensor, pressure of pumped blood components;
calculating a difference between pressures sensed in at least one time interval;
determining when the calculated difference is at least a predetermined amount; and controlling the pumping in response to at least the determination that the calculated difference is at least the predetermined amount.
129. A method of processing blood components, comprising:
rotating a chamber about an axis of rotation, wherein blood components are centrifugally separated in the chamber;
pumping at least some separated blood components from the chamber;
sensing pressure of pumped blood components;
calculating a difference between pressures sensed in at least one time interval;
determining when the calculated difference is at least a predetermined amount; and controlling the pumping in response to at least the determination that the calculated difference is at least the predetermined amount.
rotating a chamber about an axis of rotation, wherein blood components are centrifugally separated in the chamber;
pumping at least some separated blood components from the chamber;
sensing pressure of pumped blood components;
calculating a difference between pressures sensed in at least one time interval;
determining when the calculated difference is at least a predetermined amount; and controlling the pumping in response to at least the determination that the calculated difference is at least the predetermined amount.
130. The method of claim 129, wherein the pumping occurs during rotation of the chamber.
131. The method of claim 129, wherein the chamber is rotated via a centrifuge rotor, and wherein the method further comprises causing at least one valving member on the centrifuge rotor to control flow of at least some of the blood components during rotation of the rotor.
132. The method of claim 131, wherein the valving member comprises a tubing clamp.
133. The method of claim 129, wherein the chamber is rotated via a centrifuge rotor, and wherein the method further comprises causing at least one sealing member on the centrifuge rotor to create a seal during rotation of the rotor.
134. The method of claim 133, wherein the sealing member comprises a tubing welder.
135. The method of claim 129, further comprising filtering the pumped blood components with a filter so as to filter at least some of at least one blood component from the pumped blood components, wherein the filter comprises a porous filtration membrane.
136. The method of claim 135, wherein the rotating further comprises rotating the filter about the axis of rotation.
137. The method of claim 136, wherein the filter comprises a filter housing defining an interior space containing the porous filtration medium, and wherein the method comprises flowing blood components in the interior space in a direction facing generally toward the axis of rotation.
138. The method of claim 129, wherein the chamber is configured so that an interior of the chamber has a variable volume, and wherein the pumping comprises reducing the volume of the interior of the chamber.
139. The method of claim 138, further comprising applying pressure to the chamber via hydraulic fluid.
140. The method of claim 129, further comprising optically sensing the pumped blood products, and controlling the pump based on at least one of optically sensed information and sensed pressure.
141. The method of claim 140, wherein optically sensing comprises optically sensing blood components in the chamber.
142. The method of claim 140, wherein optically sensing comprises optically sensing blood components in a tubing line in flow communication with the filter.
143. The method of claim 140, wherein optically sensing comprises optically sensing blood components in the chamber and optically sensing blood components in a tubing line.
144. The method of claim 129, wherein the method further comprises passing at least some of the pumped blood components into at least one collection container.
145. The method of claim 129, wherein the blood components in the chamber are blood components of a buffy coat.
146. The method of claim 129, wherein whole blood is processed in the method.
147. A method of determining a location of at least one interface during processing of blood components, comprising:
pumping at least some centrifugally separated blood components from a chamber;
sensing pressure of the pumped blood components; and determining a location of at least one interface based on the sensed pressure, wherein the interface is associated with the pumped blood components.
pumping at least some centrifugally separated blood components from a chamber;
sensing pressure of the pumped blood components; and determining a location of at least one interface based on the sensed pressure, wherein the interface is associated with the pumped blood components.
148. The method of claim 147, wherein the interface comprises at least one of an interface between blood components and air, and an interface between differing blood components.
149. The method of claim 147, further comprising rotating a chamber about an axis of rotation, wherein blood components are centrifugally separated in the chamber.
150. The method of claim 149, wherein the pumping occurs during rotation of the chamber.
151. The method of claim 149, wherein the chamber is rotated via a centrifuge rotor, and wherein the method further comprises causing at least one valuing member on the centrifuge rotor to control flow of at least some of the blood components during rotation of the rotor.
152. The method of claim 151, wherein the valuing member comprises a tubing clamp.
153. The method of claim 149, wherein the chamber is rotated via a centrifuge rotor, and wherein the method further comprises causing at least one sealing member on the centrifuge rotor to create a seal during rotation of the rotor.
154. The method of claim 153, wherein the sealing member comprises a tubing welder.
155. The method of claim 149, further comprising filtering pumped blood components with a filter so as to filter at least some of at least one blood component from the pumped blood components, wherein the filter comprises a porous filtration membrane.
156. The method of claim 155, wherein the rotating further comprises rotating the filter about the axis of rotation.
157. The method of claim 156, wherein the filter comprises a filter housing defining an interior space containing the porous filtration medium, and wherein the method comprises flowing blood components in the interior space in a direction facing generally toward the axis of rotation.
158. The method of claim 147, further comprising filtering pumped blood components with a filter so as to filter at least some of at least one blood component from the pumped blood components, wherein the filter comprises a porous filtration membrane.
159. The method of claim 147, wherein the chamber is configured so that an interior of the chamber has a variable volume, and wherein the pumping comprises reducing the volume of the interior of the chamber.
160. The method of claim 159, further comprising applying pressure to the chamber via hydraulic fluid.
161. The method of claim 147, further comprising optically sensing the pumped blood products, and wherein the location of the location of the at least one interface is based on the sensed pressure and optically sensed information.
162. The method of claim 147, wherein the blood components in the chamber are blood components of a huffy coat.
163. The method of claim 147, wherein whole blood is processed in the method.
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CA002642652A CA2642652A1 (en) | 2002-04-16 | 2003-04-16 | Blood component processing system, apparatus and method |
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Families Citing this family (104)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US8352400B2 (en) | 1991-12-23 | 2013-01-08 | Hoffberg Steven M | Adaptive pattern recognition based controller apparatus and method and human-factored interface therefore |
SE9700495D0 (en) | 1997-02-12 | 1997-02-12 | Omega Medicinteknik Ab | Method and round bag system and centrifuge for blood treatment |
US7904187B2 (en) | 1999-02-01 | 2011-03-08 | Hoffberg Steven M | Internet appliance system and method |
SE516321C2 (en) * | 1999-05-31 | 2001-12-17 | Gambro Inc | Centrifuge for the treatment of blood and blood components |
US6524231B1 (en) * | 1999-09-03 | 2003-02-25 | Baxter International Inc. | Blood separation chamber with constricted interior channel and recessed passage |
US7211191B2 (en) * | 2004-09-30 | 2007-05-01 | Thermogenesis Corp. | Blood component separation method and apparatus |
CA2642653A1 (en) | 2002-04-16 | 2003-10-30 | Gambro Bct, Inc. | Blood component processing system, apparatus and method |
US7297272B2 (en) * | 2002-10-24 | 2007-11-20 | Fenwal, Inc. | Separation apparatus and method |
US20080299538A1 (en) * | 2003-02-28 | 2008-12-04 | Caridianbct Biotechnologies, Llc | Pathogen Inactivation of Whole Blood |
US8828226B2 (en) | 2003-03-01 | 2014-09-09 | The Trustees Of Boston University | System for assessing the efficacy of stored red blood cells using microvascular networks |
US7347932B2 (en) | 2003-08-25 | 2008-03-25 | Gambro Bct, Inc. | Apparatus and method for separating a volume of composite liquid into at least two components |
KR101188482B1 (en) | 2004-02-20 | 2012-10-05 | 테루모 비씨티, 인크. | Apparatus and method for separating a volume of composite liquid into at least two components |
JP4705098B2 (en) * | 2004-06-22 | 2011-06-22 | カリディアンビーシーティー、インコーポレーテッド | Bag assembly for composite liquid separation and manufacturing method thereof |
AU2005281481A1 (en) * | 2004-09-09 | 2006-03-16 | Lifeforce Group Plc | Apheresis tubing set |
EP2080531B1 (en) | 2004-12-28 | 2015-09-02 | Terumo BCT, Inc. | Apparatus and method for separating a volume of whole blood into at least three components |
US7473216B2 (en) * | 2005-04-21 | 2009-01-06 | Fresenius Hemocare Deutschland Gmbh | Apparatus for separation of a fluid with a separation channel having a mixer component |
AU2006262692B2 (en) | 2005-06-22 | 2010-12-09 | Caridianbct, Inc. | Apparatus and method for separating discrete volumes of a composite liquid |
US20100210441A1 (en) * | 2005-06-22 | 2010-08-19 | Caridianbct, Inc. | Apparatus And Method For Separating Discrete Volumes Of A Composite Liquid |
EP1925328B1 (en) | 2005-06-22 | 2015-07-22 | Terumo BCT, Inc. | Set of bags for the separation of a composite liquid in a centrifuge |
WO2007024518A2 (en) * | 2005-08-22 | 2007-03-01 | Gambro Inc. | Apparatus and method for separating a composite liquid into at least two components |
CA2629718A1 (en) | 2006-01-30 | 2007-10-25 | Gambro Bct, Inc. | Adjusting ph in a method of separating whole blood |
US7998052B2 (en) * | 2006-03-07 | 2011-08-16 | Jacques Chammas | Rotor defining a fluid separation chamber of varying volume |
EP2026908B1 (en) * | 2006-06-07 | 2012-01-11 | CaridianBCT, Inc. | Balancing assembly for a centrifuge |
US7487791B1 (en) * | 2006-07-18 | 2009-02-10 | Patricia Bradley | Apparatus to contain excessive lengths of medical tubing and cabling |
US8173027B2 (en) | 2006-09-06 | 2012-05-08 | Terumo Bct, Inc. | Method of separating a composite liquid into at least two components |
EP2077871A2 (en) | 2006-10-20 | 2009-07-15 | CaridianBCT Biotechnologies, LLC | Methods for washing a red blood cell component and for removing prions therefrom |
US8307988B2 (en) * | 2006-12-11 | 2012-11-13 | Samsung Electronics Co., Ltd. | Apparatus and method for separating components |
US20080147240A1 (en) * | 2006-12-19 | 2008-06-19 | Gambro Bct Inc. | Apparatus for separating a composite liquid with process control on a centrifuge rotor |
JP5405313B2 (en) * | 2006-12-20 | 2014-02-05 | テルモ ビーシーティー、インコーポレーテッド | Apparatus and method for separating a composite liquid into at least two components |
US20080200859A1 (en) * | 2007-02-15 | 2008-08-21 | Mehdi Hatamian | Apheresis systems & methods |
WO2008105972A1 (en) | 2007-02-26 | 2008-09-04 | Caridianbct, Inc. | Apparatus for separating a composite liquid with process control on a centrifuge rotor |
US20080234622A1 (en) * | 2007-03-20 | 2008-09-25 | Gambro Bct Inc. | Methods and Systems for Preparing Blood Products |
EP2764879B1 (en) | 2007-05-14 | 2016-06-29 | Terumo BCT, Inc. | Apparatus and method for collecting four components from a composite blood product |
DE102007000310A1 (en) * | 2007-06-05 | 2008-12-18 | Andreas Hettich Gmbh & Co. Kg | Insert and centrifuge with insert |
DE102007000308A1 (en) * | 2007-06-05 | 2008-12-18 | Andreas Hettich Gmbh & Co. Kg | Insert and centrifuge with insert |
DE102007000309A1 (en) * | 2007-06-05 | 2008-12-11 | Andreas Hettich Gmbh & Co. Kg | Method for cell recovery |
US8685258B2 (en) * | 2008-02-27 | 2014-04-01 | Fenwal, Inc. | Systems and methods for conveying multiple blood components to a recipient |
US8075468B2 (en) * | 2008-02-27 | 2011-12-13 | Fenwal, Inc. | Systems and methods for mid-processing calculation of blood composition |
US20090274348A1 (en) * | 2008-04-30 | 2009-11-05 | Ortho-Clinical Diagnostics, Inc. | Immunodiagnostic test apparatus having at least one imager to provide agglutination evaluations during centrifugration cycle |
WO2009134521A1 (en) * | 2008-05-02 | 2009-11-05 | Caridianbct, Inc. | Centrifuge apparatus and method for selectively reducing forces on a biologic fluid |
WO2010014330A2 (en) | 2008-07-31 | 2010-02-04 | Caridianbct, Inc. | Method and apparatus for determining the yield of at least one component |
US20110238029A1 (en) * | 2008-11-28 | 2011-09-29 | Terumo Kabushiki Kaisha | Blood bag system and cassette |
CN102215888B (en) * | 2008-11-28 | 2014-02-05 | 泰尔茂株式会社 | Blood bag system and cassette |
US20110003675A1 (en) * | 2009-07-06 | 2011-01-06 | Caridianbct, Inc. | Apparatus and Method for Automatically Loading Washing Solution In A Multi-Unit Blood Processor |
CN101607232B (en) * | 2009-07-14 | 2011-04-27 | 潘凌子 | Single-layer fully-automatic device for preparing blood components |
US9199016B2 (en) | 2009-10-12 | 2015-12-01 | New Health Sciences, Inc. | System for extended storage of red blood cells and methods of use |
NZ599890A (en) | 2009-10-12 | 2014-03-28 | Univ Pittsburgh | Oxygen depletion devices and methods for removing oxygen from red blood cells |
US11284616B2 (en) | 2010-05-05 | 2022-03-29 | Hemanext Inc. | Irradiation of red blood cells and anaerobic storage |
WO2011046841A1 (en) | 2009-10-12 | 2011-04-21 | New Health Sciences, Inc. | Blood storage bag system and depletion devices with oxygen and carbon dioxide depletion capabilities |
US8337380B2 (en) * | 2009-12-08 | 2012-12-25 | Terumo Bct, Inc. | Multi-unit blood processor with rotating valves |
DE102010000753A1 (en) | 2010-01-08 | 2011-07-14 | Andreas Hettich GmbH & Co. KG, 78532 | Cassette and system part which can be used in cooperation with the cassette in a centrifuge |
DE102010000752A1 (en) | 2010-01-08 | 2011-07-14 | Andreas Hettich GmbH & Co. KG, 78532 | Cassette and system part which can be used in cooperation with the cassette in a centrifuge |
ES2523125T3 (en) | 2010-05-27 | 2014-11-21 | Terumo Bct, Inc. | Multi-unit blood processor with temperature detection |
EP2576073B1 (en) | 2010-06-07 | 2018-06-13 | Terumo BCT, Inc. | Multi-unit blood processor with volume prediction |
WO2011159423A1 (en) * | 2010-06-17 | 2011-12-22 | Caridianbct, Inc. | Multi-unit blood processor with isolated valves for radio frequency sealing |
DE102010030238A1 (en) * | 2010-06-17 | 2011-12-22 | Lmb Lab Med Blutbank Technologie Gmbh | Flow filter for separating blood into plasma and cellular components |
EP2595755A1 (en) | 2010-07-19 | 2013-05-29 | Terumo BCT, Inc. | A centrifuge for processing blood and blood components |
US11504464B2 (en) * | 2010-08-09 | 2022-11-22 | Foce Technology International Bv | Blood centrifuge with separation, sensor and dispense control system |
JP5930483B2 (en) | 2010-08-25 | 2016-06-08 | ニュー・ヘルス・サイエンシーズ・インコーポレイテッドNew Health Sciences, Inc. | Methods for enhancing red blood cell quality and survival during storage |
US9555171B2 (en) | 2010-09-30 | 2017-01-31 | Depuy Mitek, Llc | Methods and devices for collecting separate components of whole blood |
CA2817106C (en) | 2010-11-05 | 2020-08-25 | Paul Vernucci | Irradiation of red blood cells and anaerobic storage |
WO2012064754A2 (en) | 2010-11-08 | 2012-05-18 | New York Blood Center, Inc. | Component preparation system |
US8556793B2 (en) | 2011-02-04 | 2013-10-15 | Fenwal, Inc. | Control of interface between separated blood components under lipemic and hemolytic conditions |
US9067004B2 (en) | 2011-03-28 | 2015-06-30 | New Health Sciences, Inc. | Method and system for removing oxygen and carbon dioxide during red cell blood processing using an inert carrier gas and manifold assembly |
WO2013023156A1 (en) | 2011-08-10 | 2013-02-14 | New Health Sciences, Inc. | Integrated leukocyte, oxygen and/or co2 depletion, and plasma separation filter device |
EP2804576B1 (en) | 2012-01-16 | 2017-03-08 | Fenwal, Inc. | Blood bag systems for separation of whole blood and methods of use thereof |
US9327296B2 (en) | 2012-01-27 | 2016-05-03 | Fenwal, Inc. | Fluid separation chambers for fluid processing systems |
CN106215264A (en) | 2012-03-27 | 2016-12-14 | 泰尔茂株式会社 | Blood Component Separation Device |
EP2832382B1 (en) | 2012-03-27 | 2017-06-14 | Terumo Kabushiki Kaisha | Blood component separation device |
EP2839260B1 (en) | 2012-04-20 | 2018-07-18 | Talis Biomedical Corporation | Fluidic devices and systems for sample preparation or autonomous analysis |
WO2013159116A1 (en) | 2012-04-20 | 2013-10-24 | University Of Chicago | Fluidic devices for biospecimen preservation |
US9733805B2 (en) | 2012-06-26 | 2017-08-15 | Terumo Bct, Inc. | Generating procedures for entering data prior to separating a liquid into components |
US8803090B2 (en) | 2012-11-09 | 2014-08-12 | Fenwal, Inc. | Citrate detector for blood processing system |
WO2014127122A1 (en) * | 2013-02-18 | 2014-08-21 | Terumo Bct, Inc. | System for blood separation with a separation chamber having an internal gravity valve |
EP2961269B1 (en) | 2013-02-28 | 2021-09-15 | Hemanext Inc. | Gas depletion device for blood products |
US20160017287A1 (en) * | 2013-03-04 | 2016-01-21 | Swiss Stem Cell Foundation | System for extraction of cells from a sample of tissue |
US20140371047A1 (en) * | 2013-06-18 | 2014-12-18 | L.U.M. Gmbh | Centrifuge rotor |
US10004841B2 (en) | 2013-12-09 | 2018-06-26 | Michael C. Larson | Blood purifier device and method |
US9782707B2 (en) | 2014-03-24 | 2017-10-10 | Fenwal, Inc. | Biological fluid filters having flexible walls and methods for making such filters |
US9796166B2 (en) | 2014-03-24 | 2017-10-24 | Fenwal, Inc. | Flexible biological fluid filters |
US10376627B2 (en) | 2014-03-24 | 2019-08-13 | Fenwal, Inc. | Flexible biological fluid filters |
US9968738B2 (en) | 2014-03-24 | 2018-05-15 | Fenwal, Inc. | Biological fluid filters with molded frame and methods for making such filters |
US10159778B2 (en) | 2014-03-24 | 2018-12-25 | Fenwal, Inc. | Biological fluid filters having flexible walls and methods for making such filters |
US9895700B2 (en) | 2014-10-27 | 2018-02-20 | Fenwal, Inc. | Systems and methods for controlling plasma flow rates for therapeutic exchange procedures |
KR101615746B1 (en) | 2014-11-11 | 2016-05-13 | 한국원자력연구원 | Apparatus and method of separating blood for removing leukocytes |
US9833557B2 (en) | 2014-12-19 | 2017-12-05 | Fenwal, Inc. | Systems and methods for determining free plasma hemoglobin |
WO2016134317A1 (en) | 2015-02-20 | 2016-08-25 | Terumo Bct, Inc. | Composite liquid bag system holder |
CA2978940C (en) | 2015-03-10 | 2023-10-17 | New Health Sciences, Inc. | Oxygen reduction disposable kits, devices and methods of use thereof |
BR122022005103B1 (en) | 2015-04-23 | 2023-03-14 | Hemanext Inc | BLOOD STORAGE DEVICE FOR STORING OXYGEN DEPLETED BLOOD AND METHOD FOR STORING OXYGEN DEPLETED BLOOD |
KR20180010206A (en) | 2015-05-18 | 2018-01-30 | 뉴 헬스 사이언시즈 인코포레이티드 | Method for storing whole blood, and composition thereof |
EP3124063B1 (en) | 2015-07-29 | 2019-04-10 | Fenwal, Inc. | Five-port blood separation chamber and methods of using the same |
GB2562959A (en) | 2016-01-22 | 2018-11-28 | Baxter Int | Sterile solutions product bag |
CA3011514C (en) | 2016-01-22 | 2020-11-24 | Baxter International Inc. | Method and machine for producing sterile solution product bags |
BR112018073923A2 (en) | 2016-05-27 | 2019-02-26 | New Health Sciences, Inc. | anaerobic blood storage and pathogen inactivation method |
WO2018062211A1 (en) * | 2016-09-30 | 2018-04-05 | Terumo Kabushiki Kaisha | Blood bag system and blood treatment method |
US20180104684A1 (en) * | 2016-10-16 | 2018-04-19 | Centech Corp. | Automated sample mixing and centrifuging apparatus |
WO2018102823A1 (en) | 2016-12-02 | 2018-06-07 | Terumo Bct, Inc | Composite fluid separation |
FR3061436B1 (en) | 2016-12-29 | 2022-01-21 | Maco Pharma Sa | PROTECTIVE CASE FOR COMPONENTS OF A POCKET SYSTEM |
EP3372259B1 (en) | 2017-03-07 | 2022-11-23 | Fenwal, Inc. | System and methods for separating blood under conditions of reduced plasma clarity |
CN107929835A (en) * | 2017-12-18 | 2018-04-20 | 广州市红十字会医院 | Hospital blood bank type component rinsing maching |
CN112165919A (en) * | 2018-04-16 | 2021-01-01 | 史赛克公司 | Bone fragment collector and processor |
CN112512603A (en) | 2018-05-07 | 2021-03-16 | 弗莱蒙科学公司 | Thawing biological material |
DE102019004958A1 (en) * | 2019-07-16 | 2021-01-21 | Thermo Electron Led Gmbh | Centrifuge rotor, retaining ring and retaining ring arrangement therefor, as well as centrifuge |
CN114177703B (en) * | 2021-11-30 | 2022-12-20 | 江苏吉能达环境能源科技有限公司 | Bag type dust collector with time delay and pressurization functions |
Family Cites Families (211)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US1684870A (en) | 1927-10-17 | 1928-09-18 | Frank D Lewis | Centrifugal concentrating and amalgamating apparatus of the vertical type |
US1767397A (en) * | 1928-06-02 | 1930-06-24 | A F Hubbert | Display counter |
US2616619A (en) | 1948-08-30 | 1952-11-04 | Norman A Macleod | Method and apparatus for centrifugal elutriation |
US2704888A (en) * | 1952-02-27 | 1955-03-29 | Bois Robert E Du | Rotary shear |
US2878995A (en) | 1953-08-24 | 1959-03-24 | Gen Motors Corp | Centrifuge for liquids |
US3096283A (en) | 1959-06-24 | 1963-07-02 | Becton Dickinson Co | Container for blood and machine for separating precipitates from liquid blood constituents |
UST955355I4 (en) | 1959-06-24 | 1900-01-01 | ||
US3145713A (en) | 1963-09-12 | 1964-08-25 | Protein Foundation Inc | Method and apparatus for processing blood |
FR1415623A (en) | 1964-08-07 | 1965-10-29 | Citroen Sa Andre | Method for improving combustion in a spark-ignition engine at idle idle speed and device for carrying out the method |
US3326458A (en) | 1965-05-28 | 1967-06-20 | Harold T Meryman | Container and process of storing blood |
US3489145A (en) | 1966-08-08 | 1970-01-13 | Surgeon General Of The Public | Method and apparatus for continuous separation of blood in vivo |
US3456875A (en) | 1966-08-18 | 1969-07-22 | George N Hein | Air driven centrifuge |
US3519201A (en) | 1968-05-07 | 1970-07-07 | Us Health Education & Welfare | Seal means for blood separator and the like |
NL6811659A (en) * | 1968-08-16 | 1970-02-18 | ||
SE332906B (en) | 1969-08-11 | 1971-02-22 | Aga Ab | |
BE754683A (en) | 1969-08-11 | 1971-01-18 | Aga Ab | CONTAINER INTENDED TO CONTAIN BLOOD |
US3600900A (en) | 1969-11-03 | 1971-08-24 | North American Rockwell | Temperature controlled centrifuge |
CH532423A (en) | 1970-11-24 | 1973-01-15 | Machf Reineveld N V | Self-cleaning centrifuge |
US3724747A (en) | 1971-03-15 | 1973-04-03 | Aga Ab | Centrifuge apparatus with means for moving material |
SE354582B (en) | 1971-03-15 | 1973-03-19 | Aga Ab | |
SE354581B (en) | 1971-03-15 | 1973-03-19 | Aga Ab | |
US3737096A (en) | 1971-12-23 | 1973-06-05 | Ibm | Blood processing control apparatus |
FR2180589B1 (en) | 1972-04-21 | 1975-03-21 | Loison Robert | |
SE379481B (en) | 1972-11-02 | 1975-10-13 | Separex Sa | |
US4934995A (en) | 1977-08-12 | 1990-06-19 | Baxter International Inc. | Blood component centrifuge having collapsible inner liner |
US3825175A (en) | 1973-06-06 | 1974-07-23 | Atomic Energy Commission | Centrifugal particle elutriator and method of use |
US3864089A (en) | 1973-12-10 | 1975-02-04 | Atomic Energy Commission | Multiple-sample rotor assembly for blood fraction preparation |
JPS50107565A (en) | 1974-01-29 | 1975-08-25 | ||
US4010894A (en) | 1975-11-21 | 1977-03-08 | International Business Machines Corporation | Centrifuge fluid container |
US4007871A (en) | 1975-11-13 | 1977-02-15 | International Business Machines Corporation | Centrifuge fluid container |
US4059967A (en) | 1976-02-19 | 1977-11-29 | The Community Blood Council Of Greater New York, Inc. | Process for freezing blood platelets |
US4425112A (en) | 1976-02-25 | 1984-01-10 | The United States Of America As Represented By The Department Of Health And Human Services | Flow-through centrifuge |
US4016828A (en) | 1976-03-22 | 1977-04-12 | The Perkin-Elmer Corporation | Apparatus for blood film preparation |
GB1584776A (en) | 1976-08-06 | 1981-02-18 | Gordon M | Centrifugal homogeniser |
DE2658926A1 (en) | 1976-12-24 | 1978-06-29 | Heraeus Christ Gmbh | Centrifuge rotor for washing blood cells - has two formed components between which films are mounted |
US4091989A (en) | 1977-01-04 | 1978-05-30 | Schlutz Charles A | Continuous flow fractionation and separation device and method |
US4430072A (en) | 1977-06-03 | 1984-02-07 | International Business Machines Corporation | Centrifuge assembly |
US4111355A (en) | 1977-06-15 | 1978-09-05 | Beckman Instruments, Inc. | Multi-compartment centrifuge rotor liner |
US4094461A (en) | 1977-06-27 | 1978-06-13 | International Business Machines Corporation | Centrifuge collecting chamber |
US4419089A (en) | 1977-07-19 | 1983-12-06 | The United States Of America As Represented By The Department Of Health And Human Services | Blood cell separator |
US4356958A (en) | 1977-07-19 | 1982-11-02 | The United States Of America As Represented By The Secretary Of Health And Human Services | Blood cell separator |
SE408859B (en) | 1977-08-03 | 1979-07-16 | Separex Sa | DEVICE FOR THE OCCUPATION OF UNLIMITED CORRECT RELATIVE ROTATION BETWEEN THE ENDS OF A WIRED ELEMENT |
US5571068A (en) | 1977-08-12 | 1996-11-05 | Baxter International Inc. | Centrifuge assembly |
US5006103A (en) | 1977-08-12 | 1991-04-09 | Baxter International Inc. | Disposable container for a centrifuge |
US5217427A (en) | 1977-08-12 | 1993-06-08 | Baxter International Inc. | Centrifuge assembly |
US5217426A (en) | 1977-08-12 | 1993-06-08 | Baxter International Inc. | Combination disposable plastic blood receiving container and blood component centrifuge |
US4198972A (en) | 1978-04-17 | 1980-04-22 | Pharmachem Corporation | Blood and blood component storage bags |
US4387848A (en) | 1977-10-03 | 1983-06-14 | International Business Machines Corporation | Centrifuge assembly |
US4146172A (en) * | 1977-10-18 | 1979-03-27 | Baxter Travenol Laboratories, Inc. | Centrifugal liquid processing system |
US4132349A (en) | 1977-11-11 | 1979-01-02 | Baxter Travenol Laboratories, Inc. | Rotor drive assembly for a centrifugal liquid processing apparatus |
US4142670A (en) | 1978-01-27 | 1979-03-06 | Beckman Instruments, Inc. | Chylomicron rotor |
US4386730A (en) | 1978-07-21 | 1983-06-07 | International Business Machines Corporation | Centrifuge assembly |
SE412528B (en) | 1978-07-25 | 1980-03-10 | Separex Sa | CENTRIFUGROTOR AND COLLABLE SEPARATION CONTAINER |
US4244513A (en) | 1978-09-15 | 1981-01-13 | Coulter Corporation | Centrifuge unit |
US4187979A (en) | 1978-09-21 | 1980-02-12 | Baxter Travenol Laboratories, Inc. | Method and system for fractionating a quantity of blood into the components thereof |
US4303193A (en) | 1979-01-22 | 1981-12-01 | Haemonetics Corporation | Apparatus for separating blood into components thereof |
US4413771A (en) | 1979-09-10 | 1983-11-08 | E. I. Du Pont De Nemours And Company | Method and apparatus for centrifugal separation |
US4413772A (en) | 1979-09-10 | 1983-11-08 | E. I. Du Pont De Nemours And Company | Apparatus for centrifugal separation |
US4269718A (en) | 1980-05-05 | 1981-05-26 | The Institutes Of Medical Sciences | Process and device for centrifugal separation of platelets |
US4268393A (en) | 1980-05-05 | 1981-05-19 | The Institutes Of Medical Sciences | Apparatus for centrifugal separation of platelet-rich plasma |
US4304357A (en) | 1980-06-16 | 1981-12-08 | Haemonetics Corporation | Blood processing centrifuge |
US4388184A (en) | 1980-06-19 | 1983-06-14 | Donald Brous | Pressure and fluid flow activated, simplified proportioning system |
US4350283A (en) | 1980-07-01 | 1982-09-21 | Beckman Instruments, Inc. | Centrifugal elutriator rotor |
US4389206A (en) | 1980-10-09 | 1983-06-21 | Baxter Travenol Laboratories, Inc. | Centrifugal processing apparatus and rotatable processing bowl apparatus |
US4405079A (en) | 1980-11-10 | 1983-09-20 | Haemonetics Corporation | Centrifugal displacer pump |
DE3274800D1 (en) | 1981-02-05 | 1987-02-05 | Asahi Chemical Ind | Apparatus for separating blood components |
FR2567416A2 (en) | 1981-03-09 | 1986-01-17 | Baudry Etienne | Blood stirrer |
US4389207A (en) | 1981-03-16 | 1983-06-21 | Baxter Travenol Laboratories, Inc. | Rotatable bowl assembly for centrifugal processing apparatus having a bonded and prewound umbilical system |
US4459169A (en) | 1981-03-16 | 1984-07-10 | Baxter Travenol Laboratories, Inc. | Rotatable bowl assembly for centrifugal processing apparatus having a bonded and prewound umbilical system |
US4322298A (en) | 1981-06-01 | 1982-03-30 | Advanced Blood Component Technology, Inc. | Centrifugal cell separator, and method of use thereof |
US4421503A (en) | 1981-07-09 | 1983-12-20 | Haemonetics Corporation | Fluid processing centrifuge and apparatus thereof |
US4464167A (en) | 1981-09-03 | 1984-08-07 | Haemonetics Corporation | Pheresis apparatus |
US4416654A (en) | 1981-09-03 | 1983-11-22 | Haemonetics Corporation | Pheresis apparatus |
US4439177A (en) | 1981-10-26 | 1984-03-27 | Beckman Instruments, Inc. | Rotor bucket liner |
JPS59500340A (en) | 1982-03-08 | 1984-03-01 | モトロ−ラ・インコ−ポレ−テツド | integrated circuit lead frame |
US4447221A (en) | 1982-06-15 | 1984-05-08 | International Business Machines Corporation | Continuous flow centrifuge assembly |
US4482342A (en) | 1982-06-17 | 1984-11-13 | Haemonetics Corporation | Blood processing system for cell washing |
US4680025A (en) | 1982-08-24 | 1987-07-14 | Baxter Travenol Laboratories, Inc. | Blood component collection systems and methods |
SU1091071A1 (en) | 1982-09-13 | 1984-05-07 | Всесоюзный Ордена Трудового Красного Знамени Научно-Исследовательский Институт Общей И Судебной Психиатрии Им.В.П.Сербского | Method of determination of monoaminoxydase activity in trombocytes |
SE8206767D0 (en) | 1982-11-26 | 1982-11-26 | Seroteknik Hb | SET AND DEVICE FOR BATTERY CENTRIFUGAL SEPARATION OF BLOOD |
US4610846A (en) | 1983-08-18 | 1986-09-09 | Hans Martin | Compartmentalized centrifugation chamber |
US4530691A (en) | 1983-12-13 | 1985-07-23 | Baxter Travenol Laboratories, Inc. | Centrifuge with movable mandrel |
EP0155003B1 (en) | 1984-03-15 | 1990-07-04 | ASAHI MEDICAL Co., Ltd. | Filtering unit for removing leukocytes |
DE3410286C2 (en) | 1984-03-21 | 1986-01-23 | Fresenius AG, 6380 Bad Homburg | Method for separating blood and device for carrying out the method |
SU1236366A1 (en) | 1984-08-08 | 1986-06-07 | Научно-Исследовательский Институт По Биологическим Испытаниям Химических Соединений | Method of determining parmidine and its metabolic derivatives in biological fluids |
US4776964A (en) | 1984-08-24 | 1988-10-11 | William F. McLaughlin | Closed hemapheresis system and method |
SU1255136A1 (en) | 1984-12-18 | 1986-09-07 | Предприятие П/Я Г-4740 | Method of producing thymosin from thymuses of mammalia |
EP0235160B1 (en) | 1985-09-10 | 1994-06-08 | Vereniging Het Nederlands Kanker Instituut | Method and device for the separation and isolation of blood or bone marrow components |
US4647279A (en) | 1985-10-18 | 1987-03-03 | Cobe Laboratories, Inc. | Centrifugal separator |
US4846974A (en) | 1985-11-14 | 1989-07-11 | Norfolk Scientific, Inc. | Centrifuge system and fluid container therefor |
US4708710A (en) | 1986-03-27 | 1987-11-24 | E. I. Du Pont De Nemours And Company | Particle separation process |
US4708712A (en) | 1986-03-28 | 1987-11-24 | Cobe Laboratories, Inc. | Continuous-loop centrifugal separator |
US4936998A (en) | 1986-03-28 | 1990-06-26 | Asahi Medical Co., Ltd. | Filter medium for selectively removing leucocytes |
AU7399787A (en) | 1986-05-16 | 1987-12-01 | Omega Medicinteknik A.B. | Method and apparatus for plasmapheresis |
US4720284A (en) | 1986-10-03 | 1988-01-19 | Neotech, Inc. | Method and means for separation of blood components |
US4915847A (en) | 1987-08-04 | 1990-04-10 | Baxter International Inc. | Cryoglobulin separation |
SE457856B (en) | 1986-11-17 | 1989-02-06 | Alfa Laval Separation Ab | Centrifugal separator with an axially movable annular wear |
US4933291A (en) | 1986-12-22 | 1990-06-12 | Eastman Kodak Company | Centrifugable pipette tip and pipette therefor |
DE3700122A1 (en) | 1987-01-03 | 1988-07-14 | Manfred Lutz | Chamber for separating a particle mixture according to the countercurrent centrifugation method |
US5213970A (en) | 1987-01-23 | 1993-05-25 | Board Of Regents, The University Of Texas System | Method for obtaining soluble antitumor factor |
US4940543A (en) | 1987-01-30 | 1990-07-10 | Baxter International Inc. | Plasma collection set |
US4834890A (en) | 1987-01-30 | 1989-05-30 | Baxter International Inc. | Centrifugation pheresis system |
US5641414A (en) | 1987-01-30 | 1997-06-24 | Baxter International Inc. | Blood processing systems and methods which restrict in flow of whole blood to increase platelet yields |
US5656163A (en) | 1987-01-30 | 1997-08-12 | Baxter International Inc. | Chamber for use in a rotating field to separate blood components |
US5628915A (en) | 1987-01-30 | 1997-05-13 | Baxter International Inc. | Enhanced yield blood processing systems and methods establishing controlled vortex flow conditions |
US5370802A (en) | 1987-01-30 | 1994-12-06 | Baxter International Inc. | Enhanced yield platelet collection systems and methods |
US5076911A (en) | 1987-01-30 | 1991-12-31 | Baxter International Inc. | Centrifugation chamber having an interface detection surface |
US5792372A (en) | 1987-01-30 | 1998-08-11 | Baxter International, Inc. | Enhanced yield collection systems and methods for obtaining concentrated platelets from platelet-rich plasma |
US4767397A (en) | 1987-03-09 | 1988-08-30 | Damon Corporation | Apparatus for liquid separation |
DE3711177A1 (en) | 1987-04-02 | 1988-10-13 | Dornier System Gmbh | METHOD AND DEVICE FOR OPERATING FLUIDIZED LAYER REACTORS |
US4808151A (en) | 1987-04-27 | 1989-02-28 | E. I. Du Pont De Nemours And Company | Simplified method for the preparation of human lymphokine activated killer cells |
US4939087A (en) | 1987-05-12 | 1990-07-03 | Washington State University Research Foundation, Inc. | Method for continuous centrifugal bioprocessing |
US4939081A (en) | 1987-05-27 | 1990-07-03 | The Netherlands Cancer Institute | Cell-separation |
SE458342B (en) | 1987-07-06 | 1989-03-20 | Alfa Laval Ab | CENTRIFUGAL SEPARATOR INCLUDING A ROTOR WITH A SEPARATION CHAMBER CONSISTING OF TWO DEPARTMENTS |
US4850995A (en) | 1987-08-19 | 1989-07-25 | Cobe Laboratories, Inc. | Centrifugal separation of blood |
SE462015B (en) | 1987-09-15 | 1990-04-30 | Omega Medicinteknik Ab | SETTING AND DEVICE CLEANING BLOOD CELLS |
DE3734170A1 (en) | 1987-10-09 | 1989-04-20 | Npbi Bv | Process for preparing cellulose fibres and a filter containing these |
US4798579A (en) | 1987-10-30 | 1989-01-17 | Beckman Instruments, Inc. | Rotor for centrifuge |
US4851126A (en) | 1987-11-25 | 1989-07-25 | Baxter International Inc. | Apparatus and methods for generating platelet concentrate |
DE3815645A1 (en) | 1988-05-07 | 1989-11-16 | Biotest Pharma Gmbh | A process for the production of a pure platelet concentrate from whole blood |
US4846780A (en) | 1988-08-10 | 1989-07-11 | Exxon Production Research Company | Centrifuge processor and liquid level control system |
US5078671A (en) | 1988-10-07 | 1992-01-07 | Baxter International Inc. | Centrifugal fluid processing system and method |
US4936820A (en) | 1988-10-07 | 1990-06-26 | Baxter International Inc. | High volume centrifugal fluid processing system and method for cultured cell suspensions and the like |
CA1334189C (en) | 1988-10-07 | 1995-01-31 | T. Michael Dennehey | Centrifugal fluid processing system and method |
US5229012A (en) | 1989-05-09 | 1993-07-20 | Pall Corporation | Method for depletion of the leucocyte content of blood and blood components |
US5344561A (en) | 1989-05-09 | 1994-09-06 | Pall Corporation | Device for depletion of the leucocyte content of blood and blood components |
US5316667A (en) | 1989-05-26 | 1994-05-31 | Baxter International Inc. | Time based interface detection systems for blood processing apparatus |
SU1725117A1 (en) | 1989-06-26 | 1992-04-07 | Киевский Научно-Исследовательский Институт Гигиены Труда И Профзаболеваний | Method for prognostication of toxic and allergic complications secondary to chemotherapy of tuberculosis |
EP0406485A1 (en) | 1989-07-03 | 1991-01-09 | NPBI Nederlands Produktielaboratorium voor Bloedtransfusieapparatuur en Infusievloeistoffen B.V. | A method for the removal of leukocytes from a leukocyte-containing suspension and filter unit for use with the method |
DE69020248T2 (en) | 1989-07-14 | 1996-01-25 | Terumo Corp | Filter material for the separation of leukocytes and method for its production. |
US5152905A (en) | 1989-09-12 | 1992-10-06 | Pall Corporation | Method for processing blood for human transfusion |
US5100564A (en) | 1990-11-06 | 1992-03-31 | Pall Corporation | Blood collection and processing system |
US5360545A (en) | 1989-09-12 | 1994-11-01 | Pall Corporation | Filter for obtaining platelets |
JP2523938B2 (en) | 1989-09-18 | 1996-08-14 | テルモ株式会社 | Platelet purification filter |
CA2013021C (en) | 1989-11-29 | 1995-05-09 | Richard Lewis Columbus | Blood collection device |
US5089146A (en) | 1990-02-12 | 1992-02-18 | Miles Inc. | Pre-storage filtration of platelets |
US5224921A (en) | 1990-05-31 | 1993-07-06 | Baxter International Inc. | Small volume collection chamber |
SE9002255D0 (en) | 1990-06-26 | 1990-06-26 | Eric Westberg | METHOD AND APPARATUS FOR THE PREPARATION OF BLOOD |
US5209800A (en) | 1990-08-20 | 1993-05-11 | Denco, Inc. | Total containment welding of plastic tubes |
US5217627A (en) | 1990-11-06 | 1993-06-08 | Pall Corporation | System and method for processing biological fluid |
FR2671985B1 (en) | 1991-01-30 | 1993-04-09 | Snecma | CENTRIFUGAL OIL FILTER WITH PARTICLE COLLECTION. |
US5092996A (en) | 1991-02-19 | 1992-03-03 | Miles Inc. | Blood filtering system |
US5282982A (en) | 1991-07-12 | 1994-02-01 | Wells John R | Blood washing method |
DE4126341C1 (en) | 1991-08-09 | 1993-01-28 | Fresenius Ag, 6380 Bad Homburg, De | |
JP4065927B2 (en) | 1991-12-23 | 2008-03-26 | バクスター、インターナショナル、インコーポレイテッド | Centrifuge with separable bowl and spool element providing access to separation chamber |
US5549834A (en) | 1991-12-23 | 1996-08-27 | Baxter International Inc. | Systems and methods for reducing the number of leukocytes in cellular products like platelets harvested for therapeutic purposes |
WO1993012887A1 (en) | 1991-12-23 | 1993-07-08 | Baxter International Inc. | Centrifugal processing system with direct access drawer |
US5804079A (en) | 1991-12-23 | 1998-09-08 | Baxter International Inc. | Systems and methods for reducing the number of leukocytes in cellular products like platelets harvested for therapeutic purposes |
US5437624A (en) | 1993-08-23 | 1995-08-01 | Cobe Laboratories, Inc. | Single needle recirculation system for harvesting blood components |
DE69323230D1 (en) | 1992-04-15 | 1999-03-11 | Cobe Lab | Temperature controlled centrifuge |
CA2083075A1 (en) | 1992-06-10 | 1993-12-11 | Vlado I. Matkovich | System for treating transition zone material |
JP3231086B2 (en) | 1992-06-30 | 2001-11-19 | テルモ株式会社 | Liquid separation device |
DE4393316T1 (en) | 1992-07-13 | 1995-05-11 | Pall Corp | Automated system and method for treating a biological fluid |
DE4226173A1 (en) | 1992-08-07 | 1994-02-10 | Solvay Fluor & Derivate | Bath additive |
DE4226974C2 (en) | 1992-08-14 | 1994-08-11 | Fresenius Ag | Method and device for the continuous preparation of a cell suspension |
DE69324754T2 (en) * | 1992-10-07 | 2000-01-13 | Asahi Medical Co | Filter and system for the separation of leukocytes |
EP0696211B1 (en) | 1993-04-27 | 2000-09-20 | Haemonetics Corporation | Apheresis apparatus |
US5547591A (en) | 1993-06-01 | 1996-08-20 | Asahi Medical Co., Ltd. | Method for separating a blood material into blood components by centrifugation, and centrifugal apparatus |
SE9302369D0 (en) | 1993-07-08 | 1993-07-08 | Omega Medicinteknik Ab | PASS SYSTEM PROVIDED FOR CENTRIFUGAL SEPARATION WITH USE OF THIS PASS SYSTEM |
US5427695A (en) | 1993-07-26 | 1995-06-27 | Baxter International Inc. | Systems and methods for on line collecting and resuspending cellular-rich blood products like platelet concentrate |
US5409813A (en) | 1993-09-30 | 1995-04-25 | Systemix, Inc. | Method for mammalian cell separation from a mixture of cell populations |
US5431814A (en) | 1993-10-22 | 1995-07-11 | Jorgensen; Glen | Centrifugal filter apparatus and method |
US5545339A (en) | 1994-02-25 | 1996-08-13 | Pall Corporation | Method for processing biological fluid and treating separated component |
US5733253A (en) * | 1994-10-13 | 1998-03-31 | Transfusion Technologies Corporation | Fluid separation system |
US5651766A (en) | 1995-06-07 | 1997-07-29 | Transfusion Technologies Corporation | Blood collection and separation system |
WO1996016714A1 (en) | 1994-12-02 | 1996-06-06 | Bristol-Myers Squibb Company | Method and device for separating fibrin monomer from blood plasma |
US5593378A (en) | 1995-03-07 | 1997-01-14 | Dyck; Howard F. | Centrifugal separator for flowable mixtures and having magnets and housing scrapers |
SE505621C2 (en) | 1995-03-21 | 1997-09-22 | Omega Medicinteknik Ab | Methods and extractor for buffy coat harvesting from centrifugal carbonate blood vessels |
US5704888A (en) | 1995-04-14 | 1998-01-06 | Cobe Laboratories, Inc. | Intermittent collection of mononuclear cells in a centrifuge apparatus |
US5704889A (en) | 1995-04-14 | 1998-01-06 | Cobe Laboratories, Inc. | Spillover collection of sparse components such as mononuclear cells in a centrifuge apparatus |
US5913768A (en) | 1995-04-18 | 1999-06-22 | Cobe Laboratories, Inc. | Particle filter apparatus |
US5939319A (en) | 1995-04-18 | 1999-08-17 | Cobe Laboratories, Inc. | Particle separation method and apparatus |
US6053856A (en) | 1995-04-18 | 2000-04-25 | Cobe Laboratories | Tubing set apparatus and method for separation of fluid components |
US5674173A (en) | 1995-04-18 | 1997-10-07 | Cobe Laboratories, Inc. | Apparatus for separating particles |
US5738644A (en) * | 1995-06-07 | 1998-04-14 | Cobe Laboratories, Inc. | Extracorporeal blood processing methods and apparatus |
US5704887A (en) | 1995-06-07 | 1998-01-06 | Baxter International Inc. | Easy load umbilicus holder for a centrifuge |
US5702357A (en) | 1995-06-07 | 1997-12-30 | Cobe Laboratories, Inc. | Extracorporeal blood processing methods and apparatus |
US5720716A (en) | 1995-06-07 | 1998-02-24 | Cobe Laboratories, Inc. | Extracorporeal blood processing methods and apparatus |
DE19530969A1 (en) | 1995-08-23 | 1997-02-27 | Deutsches Rotes Kreuz Blutspen | Device for the flow separation of whole blood as a mixture of liquids into individual blood components of different colors, in particular for the separation of platelet concentrate from buffy coat |
US5769811A (en) | 1995-10-31 | 1998-06-23 | Haemonetics Corporation | Blood-processing machine system |
US5964724A (en) | 1996-01-31 | 1999-10-12 | Medtronic Electromedics, Inc. | Apparatus and method for blood separation |
US5865785A (en) | 1996-02-23 | 1999-02-02 | Baxter International Inc. | Systems and methods for on line finishing of cellular blood products like platelets harvested for therapeutic purposes |
SE9600713L (en) * | 1996-02-26 | 1997-10-17 | Omega Medicinteknik Ab | Method of separating cells, especially platelets and bag set therefor |
US5846439A (en) | 1996-02-28 | 1998-12-08 | Marshfield Medical Research & Education Foundation, A Division Of Marshfield Clinic | Method of concentrating waterborne protozoan parasites |
EP0912250B1 (en) * | 1996-04-24 | 1999-11-03 | Claude Fell | Cell separation system for biological fluids like blood |
US5792038A (en) | 1996-05-15 | 1998-08-11 | Cobe Laboratories, Inc. | Centrifugal separation device for providing a substantially coriolis-free pathway |
JP2000510045A (en) | 1996-05-15 | 2000-08-08 | コウブ ラボラトリーズ,インコーポレイテッド | Method and apparatus for reducing turbulence in fluid flow |
US5904645A (en) | 1996-05-15 | 1999-05-18 | Cobe Laboratories | Apparatus for reducing turbulence in fluid flow |
SE9700495D0 (en) | 1997-02-12 | 1997-02-12 | Omega Medicinteknik Ab | Method and round bag system and centrifuge for blood treatment |
SE9701423D0 (en) | 1997-04-16 | 1997-04-16 | Omega Medicinteknik Ab | Container set and device for blood separation |
DE69841409D1 (en) * | 1997-05-20 | 2010-02-04 | Zymequest Inc | Apparatus for selectively expressing one or more liquid materials from a container |
US5976388A (en) | 1997-05-20 | 1999-11-02 | Cobe Cardiovascular Operating Co., Inc. | Method and apparatus for autologous blood salvage |
ATE210472T1 (en) | 1998-02-16 | 2001-12-15 | Moeller Feinmechanik Gmbh & Co | METHOD AND DEVICE FOR MIXING ANTICOAGULANT AND FRESH BLOOD |
US6334842B1 (en) | 1999-03-16 | 2002-01-01 | Gambro, Inc. | Centrifugal separation apparatus and method for separating fluid components |
US6296602B1 (en) | 1999-03-17 | 2001-10-02 | Transfusion Technologies Corporation | Method for collecting platelets and other blood components from whole blood |
SE516321C2 (en) | 1999-05-31 | 2001-12-17 | Gambro Inc | Centrifuge for the treatment of blood and blood components |
EP1057534A1 (en) | 1999-06-03 | 2000-12-06 | Haemonetics Corporation | Centrifugation bowl with filter core |
US6709412B2 (en) | 1999-09-03 | 2004-03-23 | Baxter International Inc. | Blood processing systems and methods that employ an in-line leukofilter mounted in a restraining fixture |
US6322488B1 (en) | 1999-09-03 | 2001-11-27 | Baxter International Inc. | Blood separation chamber with preformed blood flow passages and centralized connection to external tubing |
WO2001019429A1 (en) | 1999-09-17 | 2001-03-22 | Nuvasive, Inc. | Bone slurry recovery |
SE517032C2 (en) | 1999-10-26 | 2002-04-02 | Gambro Inc | Method and apparatus for treating blood and blood components |
US6354986B1 (en) | 2000-02-16 | 2002-03-12 | Gambro, Inc. | Reverse-flow chamber purging during centrifugal separation |
US6605223B2 (en) * | 2000-06-20 | 2003-08-12 | Medicept, Inc. | Blood component preparation (BCP) device and method of use thereof |
WO2001097943A1 (en) * | 2000-06-20 | 2001-12-27 | Medicept, Inc. | Blood component preparation (bcp) device and method of use thereof |
US20020020680A1 (en) | 2000-06-20 | 2002-02-21 | Glen Jorgensen | Blood component preparation (BCP) device and method of use thereof |
DE60139137D1 (en) | 2000-09-20 | 2009-08-13 | Thermo Fisher Scient Asheville | BLOOD CENTRIFUGAL CUP WITH INTERCHANGEABLE CHAMBER AS A HOLDING DEVICE FOR FILTERS |
US6632192B2 (en) * | 2001-03-05 | 2003-10-14 | Transvivo, Inc. | Apparatus and method for selective reduction of segmental intracellular and extracellular edema |
US20030173274A1 (en) | 2002-02-01 | 2003-09-18 | Frank Corbin | Blood component separation device, system, and method including filtration |
CA2642653A1 (en) * | 2002-04-16 | 2003-10-30 | Gambro Bct, Inc. | Blood component processing system, apparatus and method |
CA2495644A1 (en) * | 2002-08-23 | 2004-03-04 | Gambro, Inc. | Methods and apparatuses for blood component separation |
US20040119880A1 (en) * | 2002-12-20 | 2004-06-24 | Eastman Kodak Company | Extendable lens camera having mechanical shutter blocking in intermediate lens position |
-
2003
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