CA2481511A1 - Blood component processing system, apparatus, and method - Google Patents

Blood component processing system, apparatus, and method Download PDF

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Publication number
CA2481511A1
CA2481511A1 CA002481511A CA2481511A CA2481511A1 CA 2481511 A1 CA2481511 A1 CA 2481511A1 CA 002481511 A CA002481511 A CA 002481511A CA 2481511 A CA2481511 A CA 2481511A CA 2481511 A1 CA2481511 A1 CA 2481511A1
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Canada
Prior art keywords
filter
blood components
chamber
rotor
rotation
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Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA002481511A
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French (fr)
Other versions
CA2481511C (en
Inventor
Niclas Hogberg
Peter Pihlstedt
Brian M. Holmes
Geert Van Waeg
Emanuel Hallgren
Lars Persson
Lars Strandberg
Frank Corbin, Iii
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Terumo BCT Inc
Original Assignee
Gambro, Inc.
Niclas Hogberg
Peter Pihlstedt
Brian M. Holmes
Geert Van Waeg
Emanuel Hallgren
Lars Persson
Lars Strandberg
Frank Corbin, Iii
Gambro Bct, Inc.
Caridianbct, Inc.
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Publication date
Application filed by Gambro, Inc., Niclas Hogberg, Peter Pihlstedt, Brian M. Holmes, Geert Van Waeg, Emanuel Hallgren, Lars Persson, Lars Strandberg, Frank Corbin, Iii, Gambro Bct, Inc., Caridianbct, Inc. filed Critical Gambro, Inc.
Priority to CA002642652A priority Critical patent/CA2642652A1/en
Priority to CA002642653A priority patent/CA2642653A1/en
Publication of CA2481511A1 publication Critical patent/CA2481511A1/en
Application granted granted Critical
Publication of CA2481511C publication Critical patent/CA2481511C/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

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Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B04—CENTRIFUGAL APPARATUS OR MACHINES FOR CARRYING-OUT PHYSICAL OR CHEMICAL PROCESSES
    • B04B—CENTRIFUGES
    • B04B13/00—Control arrangements specially designed for centrifuges; Programme control of centrifuges
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/02—Blood transfusion apparatus
    • A61M1/0209—Multiple bag systems for separating or storing blood components
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/02—Blood transfusion apparatus
    • A61M1/0209—Multiple bag systems for separating or storing blood components
    • A61M1/0218—Multiple bag systems for separating or storing blood components with filters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/02—Blood transfusion apparatus
    • A61M1/025—Means for agitating or shaking blood containers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/14—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis
    • A61M1/16—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis with membranes
    • A61M1/26—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis with membranes and internal elements which are moving
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/14—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis
    • A61M1/16—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis with membranes
    • A61M1/26—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis with membranes and internal elements which are moving
    • A61M1/262—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis with membranes and internal elements which are moving rotating
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/36—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits
    • A61M1/3621—Extra-corporeal blood circuits
    • A61M1/3639—Blood pressure control, pressure transducers specially adapted therefor
    • A61M1/3641—Pressure isolators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/36—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits
    • A61M1/3693—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits using separation based on different densities of components, e.g. centrifuging
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/36—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits
    • A61M1/3693—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits using separation based on different densities of components, e.g. centrifuging
    • A61M1/3696—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits using separation based on different densities of components, e.g. centrifuging with means for adding or withdrawing liquid substances during the centrifugation, e.g. continuous centrifugation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/36—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits
    • A61M1/3693—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits using separation based on different densities of components, e.g. centrifuging
    • A61M1/3698—Expressing processed fluid out from the turning rotor using another fluid compressing the treatment chamber; Variable volume rotors
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B04—CENTRIFUGAL APPARATUS OR MACHINES FOR CARRYING-OUT PHYSICAL OR CHEMICAL PROCESSES
    • B04B—CENTRIFUGES
    • B04B5/00—Other centrifuges
    • B04B5/04—Radial chamber apparatus for separating predominantly liquid mixtures, e.g. butyrometers
    • B04B5/0407—Radial chamber apparatus for separating predominantly liquid mixtures, e.g. butyrometers for liquids contained in receptacles
    • B04B5/0428—Radial chamber apparatus for separating predominantly liquid mixtures, e.g. butyrometers for liquids contained in receptacles with flexible receptacles
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B04—CENTRIFUGAL APPARATUS OR MACHINES FOR CARRYING-OUT PHYSICAL OR CHEMICAL PROCESSES
    • B04B—CENTRIFUGES
    • B04B5/00—Other centrifuges
    • B04B5/04—Radial chamber apparatus for separating predominantly liquid mixtures, e.g. butyrometers
    • B04B5/0442—Radial chamber apparatus for separating predominantly liquid mixtures, e.g. butyrometers with means for adding or withdrawing liquid substances during the centrifugation, e.g. continuous centrifugation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/36—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits
    • A61M1/3621—Extra-corporeal blood circuits
    • A61M1/3627—Degassing devices; Buffer reservoirs; Drip chambers; Blood filters
    • A61M1/3633—Blood component filters, e.g. leukocyte filters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/36—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits
    • A61M1/3621—Extra-corporeal blood circuits
    • A61M1/3639—Blood pressure control, pressure transducers specially adapted therefor
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00—General characteristics of the apparatus
    • A61M2205/33—Controlling, regulating or measuring
    • A61M2205/3306—Optical measuring means
    • A61M2205/331—Optical measuring means used as turbidity change detectors, e.g. for priming-blood or plasma-hemoglubine-interface detection
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B04—CENTRIFUGAL APPARATUS OR MACHINES FOR CARRYING-OUT PHYSICAL OR CHEMICAL PROCESSES
    • B04B—CENTRIFUGES
    • B04B5/00—Other centrifuges
    • B04B5/04—Radial chamber apparatus for separating predominantly liquid mixtures, e.g. butyrometers
    • B04B5/0442—Radial chamber apparatus for separating predominantly liquid mixtures, e.g. butyrometers with means for adding or withdrawing liquid substances during the centrifugation, e.g. continuous centrifugation
    • B04B2005/045—Radial chamber apparatus for separating predominantly liquid mixtures, e.g. butyrometers with means for adding or withdrawing liquid substances during the centrifugation, e.g. continuous centrifugation having annular separation channels
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B04—CENTRIFUGAL APPARATUS OR MACHINES FOR CARRYING-OUT PHYSICAL OR CHEMICAL PROCESSES
    • B04B—CENTRIFUGES
    • B04B5/00—Other centrifuges
    • B04B5/04—Radial chamber apparatus for separating predominantly liquid mixtures, e.g. butyrometers
    • B04B5/0442—Radial chamber apparatus for separating predominantly liquid mixtures, e.g. butyrometers with means for adding or withdrawing liquid substances during the centrifugation, e.g. continuous centrifugation
    • B04B2005/0478—Radial chamber apparatus for separating predominantly liquid mixtures, e.g. butyrometers with means for adding or withdrawing liquid substances during the centrifugation, e.g. continuous centrifugation with filters in the separation chamber
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B04—CENTRIFUGAL APPARATUS OR MACHINES FOR CARRYING-OUT PHYSICAL OR CHEMICAL PROCESSES
    • B04B—CENTRIFUGES
    • B04B13/00—Control arrangements specially designed for centrifuges; Programme control of centrifuges
    • B04B2013/006—Interface detection or monitoring of separated components

Abstract

A system and method are used in connection with processing of blood components. The processing of blood components may involve centrifugal separation and/or filtering of the blood components. In some examples, at least some blood components are centrifugally separated in a chamber and then filtered via a filter (31) rotating along with a centrifuge rotor (1), wherein the filter is located closer than the chamber to an axis of rotation of the rotor. The filter may include a porous filtration medium configured to filter leukocytes, platelets, and/or red blood cells. Some examples include a pressure sensor sensing pressure of pumped blood components. The sensed pressure may be used in connection with controlling the pumping of the blood products and/or in connection with determining the location of an interface associated with the blood products. Other uses of the sensed pressure are also possible.

Claims (163)

WHAT IS CLAIMED IS:
1. A system for processing blood components, the system comprising:
a separation chamber comprising a chamber interior in which blood components are centrifugally separated, and an outlet port for passing at least some of the centrifugally separated blood components from the chamber interior;
a flow path in flow communication with the outlet port of the separation chamber;
a filter comprising a filter inlet in flow communication with the flow path, a porous filtration medium configured to filter at least some of at least one blood component from centrifugally separated blood components passed to the filter via the flow path, and a filter outlet for filtered blood components; and a centrifuge rotor configured to be rotated about an axis of rotation, the rotor comprising a first portion configured to receive the separation chamber and a second portion configured to receive the filter, wherein the first and second portions are positioned with respect to one another so that when the separation chamber is received in the first portion and the filter is received in the second portion, the filter is closer than the interior of the separation chamber to the axis of rotation, wherein the system is configured so that the rotor rotates during filtering of at least some of said at least one blood component via the filter.
2. The system of claim 1, wherein the system is configured so that when the filter is received in the second portion, the filter is eccentric with respect to the axis of rotation.
3. The system of claim 2, wherein the system is configured so that when the filter is received in the second portion, the filter is at least close to the axis of rotation and wherein the axis of rotation does not intersect an interior flow path defined by the filter.
4. The system of claim 2, wherein the filter comprises a filter housing inflow port and a filter housing outflow port, and wherein the system is configured so that when the filter is received in the second portion, the filter housing outflow port is located closer than the filter housing inflow port to the axis of rotation.
5. The system of claim 2, wherein the system is configured so that when the filter is received in the second portion, the filter housing outflow port is closer than the porous filtration medium to the axis of rotation.
6. The system of claim 2, wherein the system is configured so that when the filter is received in the second portion, the filter housing outflow port is above the filter housing inflow port.
7. The system of claim 2, wherein the filter comprises a filter housing defining an interior space containing the porous filtration medium, wherein the filter inlet and filter outlet are in flow communication with the interior space, and wherein the system is configured so that when the filter is received in the second portion, the filter is positioned so that blood components flow in the interior space in a direction facing generally toward the axis of rotation.
8. The system of claim 7, wherein the filter housing defines a filter housing inflow port for passing blood components to the interior space and a filter housing outflow port for passing blood components from the interior space, and wherein the system is configured so that when the filter is received in the second portion, the filter housing outflow port is closer than the filter housing inflow port to the axis of rotation.
9. The system of claim 7, wherein the filter housing defines a filter housing inflow port for passing blood components to the interior space and a filter housing outflow port for passing blood components from the interior space, and wherein the system is configured so that when the filter is received in the second portion, the filter housing outflow port is closer than the porous filtration medium to the axis of rotation.
10. The system of claim 7, wherein the filter housing defines a filter housing inflow port for passing blood components to the interior space and a filter housing outflow port for passing blood components from the interior space, and wherein the system is configured so that when the filter is received in the second portion, the filter housing outflow port is above the filter housing inflow port.
11. The system of claim 1, wherein the second portion comprises at least one of a ledge and a slot configured to receive the filter, the at least one of a ledge and a slot being positioned under a top surface of the rotor.
12. The system of claim 1, wherein the rotor comprises a holder configured to hold the filter with respect to the rotor.
13. The system of claim 1, wherein the flow path comprises a first tubing portion having one end coupled to the outlet port of the separation chamber and another end coupled to the filter inlet, and wherein the system further comprises a second tubing portion having an end coupled to the filter outlet, wherein the second tubing portion extends in a direction facing generally away from the axis of rotation.
14. The system of claim 13, further comprising a third tubing portion downstream from the second tubing portion, wherein the third tubing portion extends in a direction facing generally toward the axis of rotation.
15. The system of claim 14, wherein the rotor comprises a groove configured to receive at least some of the second and third tubing portions.
16. The system of claim 1, wherein the system further comprises a collection container comprising an inlet in flow communication with the filter outlet, and wherein the second portion of the rotor comprises a cavity configured to receive the filter and the collection container.
17. The system of claim 1, wherein the axis of rotation extends through the second portion of the rotor.
18. The system of claim 1, wherein the chamber is configured so that the chamber interior has a variable volume.
19. The system of claim 1, wherein the separation chamber comprises a blood component separation bag.
20. The system of claim 19, wherein at least a portion of the blood component separation bag is formed of at least one of flexible and semi-rigid material so that the chamber interior has a variable volume.
21. The system of claim 19, wherein the bag has a generally annular ring shape defining a central opening.
22. The system of claim 19, wherein the chamber interior includes a tapered portion leading to the outlet port.
23. The system of claim 1, wherein the system comprises a tubing line having an end coupled to the filter outlet, and wherein the rotor comprises at least one support member configured to support the separation chamber, wherein the at least one support member comprises a guide groove configured to receive a portion of the tubing line and at least one of a controllable clamp and a welder associated with the groove.
24. The system of claim 23, wherein the separation chamber comprises at least one guide hole configured to receive the at least one support member.
25. The system of claim 1, wherein the rotor comprises a plurality of support members located in an asymmetric fashion with respect to the axis of rotation, and wherein the separation chamber comprises a plurality of guide holes, each of the guide holes being configured to receive a respective one of the support members.
26. The system of claim 1, wherein the separation chamber has a ring shape.
27. The system of claim 1, further comprising at least one valuing member on the centrifuge rotor, the valuing member being configured to control flow of at least some of the blood components during rotation of the rotor.
28. The system of claim 27, wherein the valuing member comprises a tubing clamp.
29. The system of claim 1, further comprising at least one sealing member on the centrifuge rotor, the sealing member being configured to create a seal during rotation of the rotor.
30. The system of claim 29, wherein the sealing member comprises a tubing welder.
31. The system of claim 1, further comprising a pump configured to pump at least some of the centrifugally separated blood components from the chamber to the filter via the flow path.
32. The system of claim 31, wherein the system is configured so that the pump pumps blood components from the chamber during rotation of the centrifuge rotor.
33. The system of claim 31, wherein the chamber is configured so that the chamber interior has a variable volume, and wherein the pump is configured to reduce the volume of the chamber interior.
34. The system of claim 33, wherein the pump is configured to apply pressure to the chamber via hydraulic fluid.
35. The system of claim 34, further comprising a sensor configured to sense pressure of pumped blood components, wherein the sensor senses pressure of the hydraulic fluid.
36. The system of claim 31, further comprising a sensor configured to sense pressure of pumped blood components, wherein the system is configured to control the pump based on at least the pressure sensed by the pressure sensor.
37. The system of claim 36, wherein the system is configured to calculate a difference between pressures sensed by the pressure sensor in at least one time interval, determine when the calculated difference is at least a predetermined amount, and control the pump in response to at least the determination that the calculated difference is at least the predetermined amount.
38. The system of claim 36, further comprising an optical sensor, wherein the system is configured to control the pump based on at least information sensed by the optical sensor and pressure sensed by the pressure sensor.
39. A method of processing blood components, comprising:
providing the system of claim 1;

placing the separation chamber in the first portion of the rotor and the filter in the second portion of the rotor, wherein the filter is located closer than an interior of the separation chamber to the axis of rotation of the rotor;
rotating the centrifuge rotor, the separation chamber, and the filter about the axis of rotation of the centrifuge rotor, wherein blood components are centrifugally separated in the chamber interior;
removing at least some of the centrifugally separated blood components from the separation chamber via the outlet port; and filtering the removed blood components with the filter so as to filter at least some of at least one blood component from the removed blood components, wherein at least a portion of the filtering occurs during said rotating.
40. A method of processing blood components, comprising:
placing a separation chamber in a first portion of a centrifuge rotor and a filter in a second portion of the rotor, wherein the filter is located closer than an interior of the separation chamber to an axis of rotation of the centrifuge rotor, and wherein the filter comprises a porous filtration medium;
rotating the centrifuge rotor, the separation chamber, and the filter about the axis of rotation, wherein blood components are centrifugally separated in a chamber interior of the separation chamber;
removing at least some of the centrifugally separated blood components from the separation chamber via an outlet port of the separation chamber; and filtering the removed blood components with the filter so as to filter at least some of at least one blood component from the removed blood components, wherein at least a portion of the filtering occurs during said rotating.
41. The method of claim 40, wherein the method further comprises passing the filtered blood components into at least one collection container.
42. The method of claim 40, wherein the blood components in the separation chamber are blood components of a buffy coat.
43. The method of claim 40, wherein whole blood is processed in the method.
44. The method of claim 40, wherein the filter comprises a filter housing defining an interior space containing the porous filtration medium, and wherein the method comprises flowing blood components in the interior space in a direction facing generally toward the axis of rotation.
45. The method of claim 40, further comprising causing at least one valuing member on the centrifuge rotor to control flow of at least some of the blood components during rotation of the rotor.
46. The method of claim 45, wherein the valuing member comprises a tubing clamp.
47. The method of claim 40, further comprising causing at least one sealing member on the centrifuge rotor to create a seal during rotation of the rotor.
48. The method of claim 47, wherein the sealing member comprises a tubing welder.
49. The method of claim 40, further comprising pumping at least some of the centrifugally separated blood components from the chamber to the filter.
50. The method of claim 49, wherein the pumping occurs during rotation of the centrifuge rotor.
51. The method of claim 49, wherein the pumping comprises reducing the volume of an interior of the chamber.
52. The method of claim 51, further comprising applying pressure to the chamber via hydraulic fluid.
53. The method of claim 49, further comprising sensing pressure of pumped blood components, and controlling the pumping based on at least the sensed pressure.
54. The method of claim 53, further comprising calculating a difference between pressures sensed in at least one time interval, determining when the calculated difference is at least a predetermined amount, and controlling the pumping in response to at least the determination that the calculated difference is at least the predetermined amount.
55. The method of claim 53, further comprising optically sensing the pumped blood products, and controlling the pumping based on at least one of optically sensed information and sensed pressure.
56. An apparatus for use with a centrifuge for processing blood components, the apparatus comprising:
a separation chamber comprising a chamber interior in which blood components are centrifugally separated, and an outlet port for passing at least some of the centrifugally separated blood components from the chamber interior;
a flow path in flow communication with the outlet port of the separation chamber; and a filter comprising a filter inlet in flow communication with the flow path, a porous filtration medium configured to filter at least some of at least one blood component from centrifugally separated blood components passed to the filter via the flow path, and a filter outlet for filtered blood components, wherein the centrifuge for use with the apparatus comprises a rotor configured to be rotated about an axis of rotation, the rotor comprising a first portion configured to receive the separation chamber and a second portion configured to receive the filter, wherein the first and second portions are positioned with respect to one another so that when the separation chamber is received in the first portion and the filter is received in the second portion, the filter is closer than the interior of the separation chamber to the axis of rotation, and wherein the centrifuge is configured so'that the rotor rotates during filtering of at least some of said at least one blood component via the filter.
57. The apparatus of claim 56, wherein the apparatus further comprises a collection container comprising an inlet in flow communication with the filter outlet, and wherein the second portion of the rotor comprises a cavity configured to receive the filter and the collection container.
58. The system of claim 56, wherein the chamber is configured so that the chamber interior has a variable volume.
59. The apparatus of claim 56, wherein the separation chamber comprises a blood component separation bag.
60. The apparatus of claim 59, wherein at least a portion of the blood component separation bag is formed of at least one of flexible and semi-rigid material so that the chamber interior has a variable volume.
61. The apparatus of claim 59, wherein the bag has a generally annular ring shape defining a central opening.
62. The apparatus of claim 59, wherein the chamber interior includes a tapered portion leading to the outlet port.
63. The apparatus of claim 56, wherein the separation chamber comprises at least one guide hole configured to receive at least one support member of the centrifuge.
64. The apparatus of claim 56, wherein the rotor comprises a plurality of support members located in an asymmetric fashion with respect to the axis of rotation, and wherein the separation chamber comprises a plurality of guide holes, each of the guide holes being configured to receive a respective one of the support members.
65. The apparatus of claim 56, wherein the apparatus is configured to be disposed after being used for processing of blood components from a single donor.
66. The apparatus of claim 56, wherein the separation chamber has a ring shape.
67. A system for processing blood components, comprising:
a chamber comprising an interior configured to contain separated blood components, and an outlet port for passing at least some of the separated blood components from the interior;
a flow path in flow communication with the outlet port of the chamber;
a filter comprising a filter inlet in flow communication with the flow path, a porous filtration medium configured to filter at least some of at least one blood component from separated blood components passed to the filter via the flow path, and a filter outlet for filtered blood components;
a pump configured to pump at least some of the separated blood components from the chamber to the filter via the flow path; and a pressure sensor configured to sense pressure of blood components pumped to the filter, wherein the system is configured to control the pump based on at least the pressure sensed by the pressure sensor.
61 63. The system of claim 67, wherein the pump comprises a portion of a centrifuge.
69. The system of claim 67, wherein the pump comprises at least a portion of a blood component expressor.
70. The system of claim 67, wherein the chamber comprises a separation chamber, wherein blood components are centrifugally separated in the interior of the container, and wherein the system further comprises a centrifuge rotor configured to be rotated about an axis of rotation, the rotor comprising a portion configured to receive the chamber.
71. The system of claim 70, wherein the system is configured so that the pump pumps blood components from the chamber during rotation of the centrifuge rotor.
72. The system of claim 70, further comprising at least one valving member on the centrifuge rotor, the valving member being configured to control flow of at least some of the blood components during rotation of the rotor.
73. The system of claim 72, wherein the valving member comprises a tubing clamp.
74. The system of claim 70, further comprising at least one sealing member on the centrifuge rotor, the sealing member being configured to create a seal during rotation of the rotor.
75. The system of claim 74, wherein the sealing member comprises a tubing welder.
76. The system of claim 70, wherein the rotor further comprises a portion configured to receive the filter, and wherein the system is configured so that the rotor rotates during filtering via the filter.
77. The system of claim 76, wherein the filter comprises a filter housing defining an interior space containing the porous filtration medium, wherein the system is configured so that when the filter is received in the portion of the rotor configured to receive the filter, the filter is positioned so that blood components flow in the interior space in a direction facing generally toward the axis of rotation.
78. The system of claim 67, wherein the chamber comprises a bag formed of at least one of flexible and semi-rigid material so that the interior of the chamber has a variable volume.
79. The system of claim 78, wherein the bag has a generally annular shape defining a central opening.
80. The system of claim 67, wherein the chamber is configured so that the interior of the chamber has a variable volume.
81. The system of claim 80, wherein the pump is configured to reduce the volume of the chamber interior.
82. The system of claim 81, wherein the pump is configured to apply pressure to the chamber via hydraulic fluid.
83. The system of claim 82, wherein the sensor senses pressure of the hydraulic fluid.
84. The system of claim 67, wherein the system is configured to calculate a difference between pressures sensed by the pressure sensor in at least one time interval where blood components are pumped by the pump, determine when the calculated difference is at least a predetermined amount, and control the pump in response to at least the determination that the calculated difference is at least the predetermined amount.
85. The system of claim 67, further comprising an optical sensor, wherein the system is configured to control the pump based on at least information sensed by the optical sensor and pressure sensed by the pressure sensor.
86. The system of claim 85, wherein said optical sensor is positioned to sense blood components in the chamber.
87. The system of claim 85, wherein said optical sensor is positioned to sense blood components in a tubing line in flow communication with the filter.
88. The system of claim 85, wherein said optical sensor comprises a first optical sensor and a second optical sensor, the first optical sensor being positioned to sense blood components in the chamber and the second optical sensor being positioned to sense blood components in a tubing line in flow communication with the filter.
89. A method of processing blood components, comprising:
providing the system of claim 67;
pumping, via the pump, at least some of the separated blood components from the chamber;
filtering the pumped blood components with the filter so as to filter at least some of at least one blood component from the pumped blood components;
sensing, via the pressure sensor, pressure of blood components pumped to the filter; and controlling the pumping based on at least the pressure sensed by the pressure sensor.
90. A method of processing blood components, comprising:

pumping at least some separated blood components from a chamber;
filtering the pumped blood components with a filter so as to filter at least some of at least one blood component from the pumped blood components, wherein the filter comprises a porous filtration membrane;
sensing pressure of blood components pumped to the filter; and controlling the pumping based on at least the pressure sensed by the pressure sensor.
91. The method of claim 90, further comprising rotating the chamber about an axis of rotation, wherein blood components are centrifugally separated in an interior of the chamber.
92. The method of claim 91, wherein the pumping occurs during rotation of the chamber.
93. The method of claim 91, wherein a centrifuge is used to rotate the chamber, and wherein said at least some separated blood components are pumped from the chamber while the chamber is received on a rotor of the centrifuge.
94. The method of claim 93, further comprising causing at least one valuing member on the centrifuge rotor to control flow of at least some of the blood components during rotation of the rotor.
95. The method of claim 94, wherein the valuing member comprises a tubing clamp.
96. The method of claim 93, further comprising causing at least one sealing member on the centrifuge rotor to create a seal during rotation of the rotor.
97. The method of claim 96, wherein the sealing member comprises a tubing welder.
98. The method of claim 91, wherein a centrifuge is used to rotate the chamber, and wherein said at least some separated blood components are pumped from the chamber after the chamber is removed from a rotor of the centrifuge.
99. The method of claim 90, further comprising rotating the filter about an axis of rotation during the filtering.
100. The method of claim 99, wherein the filter comprises a filter housing defining an interior space containing the porous filtration medium, and wherein the method comprises flowing blood components in the interior space in a direction facing generally toward the axis of rotation.
101. The method of claim 90, wherein the chamber is configured so that an interior of the chamber has a variable volume, and wherein the pumping comprises reducing the volume of the interior of the chamber.
102. The method of claim 101, further comprising applying pressure to the chamber via hydraulic fluid.
103. The method of claim 90, further comprising calculating a difference between pressures sensed in at least one time interval, determining when the calculated difference is at least a predetermined amount, and controlling the pumping in response to at least the determination that the calculated difference is at least the predetermined amount.
104. The method of claim 90, further comprising optically sensing the pumped blood products, and controlling the pumping based on at least one of optically sensed information and sensed pressure.
105. The method of claim 104, wherein optically sensing comprises optically sensing blood components in the chamber.
106. The method of claim 104, wherein optically sensing comprises optically sensing blood components in a tubing line in flow communication with the filter.
107. The method of claim 104, wherein optically sensing comprises optically sensing blood components in the chamber and optically sensing blood components in a tubing line in flow communication with the filter.
108. The method of claim 90, wherein the method further comprises passing the filtered blood components into at least one collection container.
109. The method of claim 90, wherein the blood components in the chamber are blood components of a buffy coat.
110. The method of claim 90, wherein whole blood is processed in the method.
111. A system for processing blood components, comprising:
a separation chamber comprising a chamber interior in which blood components are centrifugally separated, and an outlet port for passing at least some of the centrifugally separated blood components from the chamber interior;
a flow path in flow communication with the outlet port of the separation chamber; a pump configured to pump at least some of the centrifugally separated blood components from the chamber and through the flow path; and a pressure sensor configured to sense pressure of blood components pumped by the pump; and a centrifuge rotor configured to be rotated about an axis of rotation, the rotor comprising a portion configured to receive the separation chamber, wherein the system is configured to calculate a difference between pressures sensed by the pressure sensor in at least one time interval, determine when the calculated difference is at least a predetermined amount, and control the pump in response to at least the determination that the calculated difference is at least the predetermined amount.
112. The system of claim 111, wherein the system is configured so that the pump pumps blood components from the chamber during rotation of the centrifuge rotor.
113. The system of claim 111, further comprising at least one valving member on the centrifuge rotor, the valving member being configured to control flow of at least some of the blood components during rotation of the rotor.
114. The system of claim 113, wherein the valving member comprises a tubing clamp.
115. The system of claim 111, further comprising a sealing member on the centrifuge rotor, the sealing member being configured to create a seal during rotation of the rotor.
116. The system of claim 115, wherein the sealing member comprises a tubing welder.
117. The system of claim 111, further comprising a filter comprising a porous filtration membrane configured to filter at least one blood component from the pumped blood products.
118. The system of claim 111, wherein the chamber comprises a bag formed of at least one of flexible and semi-rigid material so that the interior of the chamber has a variable volume.
119. The system of claim 118, wherein the bag has a generally annular shape defining a central opening.
120. The system of claim 111, wherein the chamber is configured so that the chamber interior has a variable volume,
121. The system of claim 120, wherein the pump is configured to reduce the volume of the chamber interior.
122. The system of claim 121, wherein the pump is configured to apply pressure to the chamber via hydraulic fluid.
123. The system of claim 122, wherein the sensor senses pressure of the hydraulic fluid.
124. The system of claim 111, further comprising an optical sensor, wherein the system is configured to control the pump based on at least information sensed by the optical sensor and pressure sensed by the pressure sensor.
125. The system of claim 124, wherein said optical sensor is positioned to sense blood components in the chamber.
126. The system of claim 124, wherein said optical sensor is positioned to sense blood components in a tubing line in flow communication with the filter.
127. The system of claim 124, wherein said optical sensor comprises a first optical sensor and a second optical sensor, the first optical sensor being positioned to sense blood components in the chamber and the second optical sensor being positioned to sense blood components in a tubing line associated with the flow path.
128. A method of processing blood components, comprising:
providing the system of claim 111;
rotating the centrifuge rotor and the chamber about the axis of rotation, wherein blood components are centrifugally separated in the chamber;
pumping, via the pump, at least some separated blood components from the chamber;
sensing, via the pressure sensor, pressure of pumped blood components;
calculating a difference between pressures sensed in at least one time interval;
determining when the calculated difference is at least a predetermined amount; and controlling the pumping in response to at least the determination that the calculated difference is at least the predetermined amount.
129. A method of processing blood components, comprising:
rotating a chamber about an axis of rotation, wherein blood components are centrifugally separated in the chamber;
pumping at least some separated blood components from the chamber;
sensing pressure of pumped blood components;
calculating a difference between pressures sensed in at least one time interval;
determining when the calculated difference is at least a predetermined amount; and controlling the pumping in response to at least the determination that the calculated difference is at least the predetermined amount.
130. The method of claim 129, wherein the pumping occurs during rotation of the chamber.
131. The method of claim 129, wherein the chamber is rotated via a centrifuge rotor, and wherein the method further comprises causing at least one valving member on the centrifuge rotor to control flow of at least some of the blood components during rotation of the rotor.
132. The method of claim 131, wherein the valving member comprises a tubing clamp.
133. The method of claim 129, wherein the chamber is rotated via a centrifuge rotor, and wherein the method further comprises causing at least one sealing member on the centrifuge rotor to create a seal during rotation of the rotor.
134. The method of claim 133, wherein the sealing member comprises a tubing welder.
135. The method of claim 129, further comprising filtering the pumped blood components with a filter so as to filter at least some of at least one blood component from the pumped blood components, wherein the filter comprises a porous filtration membrane.
136. The method of claim 135, wherein the rotating further comprises rotating the filter about the axis of rotation.
137. The method of claim 136, wherein the filter comprises a filter housing defining an interior space containing the porous filtration medium, and wherein the method comprises flowing blood components in the interior space in a direction facing generally toward the axis of rotation.
138. The method of claim 129, wherein the chamber is configured so that an interior of the chamber has a variable volume, and wherein the pumping comprises reducing the volume of the interior of the chamber.
139. The method of claim 138, further comprising applying pressure to the chamber via hydraulic fluid.
140. The method of claim 129, further comprising optically sensing the pumped blood products, and controlling the pump based on at least one of optically sensed information and sensed pressure.
141. The method of claim 140, wherein optically sensing comprises optically sensing blood components in the chamber.
142. The method of claim 140, wherein optically sensing comprises optically sensing blood components in a tubing line in flow communication with the filter.
143. The method of claim 140, wherein optically sensing comprises optically sensing blood components in the chamber and optically sensing blood components in a tubing line.
144. The method of claim 129, wherein the method further comprises passing at least some of the pumped blood components into at least one collection container.
145. The method of claim 129, wherein the blood components in the chamber are blood components of a buffy coat.
146. The method of claim 129, wherein whole blood is processed in the method.
147. A method of determining a location of at least one interface during processing of blood components, comprising:
pumping at least some centrifugally separated blood components from a chamber;
sensing pressure of the pumped blood components; and determining a location of at least one interface based on the sensed pressure, wherein the interface is associated with the pumped blood components.
148. The method of claim 147, wherein the interface comprises at least one of an interface between blood components and air, and an interface between differing blood components.
149. The method of claim 147, further comprising rotating a chamber about an axis of rotation, wherein blood components are centrifugally separated in the chamber.
150. The method of claim 149, wherein the pumping occurs during rotation of the chamber.
151. The method of claim 149, wherein the chamber is rotated via a centrifuge rotor, and wherein the method further comprises causing at least one valuing member on the centrifuge rotor to control flow of at least some of the blood components during rotation of the rotor.
152. The method of claim 151, wherein the valuing member comprises a tubing clamp.
153. The method of claim 149, wherein the chamber is rotated via a centrifuge rotor, and wherein the method further comprises causing at least one sealing member on the centrifuge rotor to create a seal during rotation of the rotor.
154. The method of claim 153, wherein the sealing member comprises a tubing welder.
155. The method of claim 149, further comprising filtering pumped blood components with a filter so as to filter at least some of at least one blood component from the pumped blood components, wherein the filter comprises a porous filtration membrane.
156. The method of claim 155, wherein the rotating further comprises rotating the filter about the axis of rotation.
157. The method of claim 156, wherein the filter comprises a filter housing defining an interior space containing the porous filtration medium, and wherein the method comprises flowing blood components in the interior space in a direction facing generally toward the axis of rotation.
158. The method of claim 147, further comprising filtering pumped blood components with a filter so as to filter at least some of at least one blood component from the pumped blood components, wherein the filter comprises a porous filtration membrane.
159. The method of claim 147, wherein the chamber is configured so that an interior of the chamber has a variable volume, and wherein the pumping comprises reducing the volume of the interior of the chamber.
160. The method of claim 159, further comprising applying pressure to the chamber via hydraulic fluid.
161. The method of claim 147, further comprising optically sensing the pumped blood products, and wherein the location of the location of the at least one interface is based on the sensed pressure and optically sensed information.
162. The method of claim 147, wherein the blood components in the chamber are blood components of a huffy coat.
163. The method of claim 147, wherein whole blood is processed in the method.
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US20070084807A1 (en) 2007-04-19
ATE382382T1 (en) 2008-01-15
CA2642653A1 (en) 2003-10-30
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DE60322600D1 (en) 2008-09-11
US20040026341A1 (en) 2004-02-12
CA2481511C (en) 2009-12-08
US7648452B2 (en) 2010-01-19
EP1920792A1 (en) 2008-05-14
DE60331794D1 (en) 2010-04-29
EP1494735A2 (en) 2005-01-12
US7166217B2 (en) 2007-01-23
US7279107B2 (en) 2007-10-09
US7396451B2 (en) 2008-07-08
WO2003089027A2 (en) 2003-10-30
US7413665B2 (en) 2008-08-19
US20080314822A1 (en) 2008-12-25
ATE402723T1 (en) 2008-08-15
EP1920792B1 (en) 2010-03-17
US20070255505A1 (en) 2007-11-01
US20090127206A1 (en) 2009-05-21
JP4376635B2 (en) 2009-12-02
US20070084806A1 (en) 2007-04-19
DE60318418T2 (en) 2009-01-02
US20040104182A1 (en) 2004-06-03
WO2003089027A3 (en) 2004-02-12
AU2003223645A1 (en) 2003-11-03
DE60318418D1 (en) 2008-02-14
JP2005523080A (en) 2005-08-04
EP1640027A1 (en) 2006-03-29
US7497944B2 (en) 2009-03-03
US7708889B2 (en) 2010-05-04
EP1494735B1 (en) 2008-01-02
EP1640027B1 (en) 2008-07-30

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