CA2473465C - Apparatus for low coherence ranging - Google Patents

Apparatus for low coherence ranging Download PDF

Info

Publication number
CA2473465C
CA2473465C CA2473465A CA2473465A CA2473465C CA 2473465 C CA2473465 C CA 2473465C CA 2473465 A CA2473465 A CA 2473465A CA 2473465 A CA2473465 A CA 2473465A CA 2473465 C CA2473465 C CA 2473465C
Authority
CA
Canada
Prior art keywords
intensity distribution
arrangement
electro
sample
magnetic radiation
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CA2473465A
Other languages
French (fr)
Other versions
CA2473465A1 (en
Inventor
Guillermo J. Tearney
Brett Eugene Bouma
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
General Hospital Corp
Original Assignee
General Hospital Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by General Hospital Corp filed Critical General Hospital Corp
Publication of CA2473465A1 publication Critical patent/CA2473465A1/en
Application granted granted Critical
Publication of CA2473465C publication Critical patent/CA2473465C/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01B—MEASURING LENGTH, THICKNESS OR SIMILAR LINEAR DIMENSIONS; MEASURING ANGLES; MEASURING AREAS; MEASURING IRREGULARITIES OF SURFACES OR CONTOURS
    • G01B9/00—Measuring instruments characterised by the use of optical techniques
    • G01B9/02—Interferometers
    • G01B9/02034—Interferometers characterised by particularly shaped beams or wavefronts
    • G01B9/02035—Shaping the focal point, e.g. elongated focus
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01B—MEASURING LENGTH, THICKNESS OR SIMILAR LINEAR DIMENSIONS; MEASURING ANGLES; MEASURING AREAS; MEASURING IRREGULARITIES OF SURFACES OR CONTOURS
    • G01B9/00—Measuring instruments characterised by the use of optical techniques
    • G01B9/02—Interferometers
    • G01B9/02015—Interferometers characterised by the beam path configuration
    • G01B9/02027—Two or more interferometric channels or interferometers
    • G01B9/02028—Two or more reference or object arms in one interferometer
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01B—MEASURING LENGTH, THICKNESS OR SIMILAR LINEAR DIMENSIONS; MEASURING ANGLES; MEASURING AREAS; MEASURING IRREGULARITIES OF SURFACES OR CONTOURS
    • G01B9/00—Measuring instruments characterised by the use of optical techniques
    • G01B9/02—Interferometers
    • G01B9/02034—Interferometers characterised by particularly shaped beams or wavefronts
    • G01B9/02035—Shaping the focal point, e.g. elongated focus
    • G01B9/02036—Shaping the focal point, e.g. elongated focus by using chromatic effects, e.g. a wavelength dependent focal point
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01B—MEASURING LENGTH, THICKNESS OR SIMILAR LINEAR DIMENSIONS; MEASURING ANGLES; MEASURING AREAS; MEASURING IRREGULARITIES OF SURFACES OR CONTOURS
    • G01B9/00—Measuring instruments characterised by the use of optical techniques
    • G01B9/02—Interferometers
    • G01B9/0209—Low-coherence interferometers
    • G01B9/02091—Tomographic interferometers, e.g. based on optical coherence
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
    • G01N21/47—Scattering, i.e. diffuse reflection
    • G01N21/4795—Scattering, i.e. diffuse reflection spatially resolved investigating of object in scattering medium

Abstract

An apparatus for performing low coherence ranging of a sample with high transverse resolution and large depth of focus, comprising an optical ranging system comprising a light source, a means for directing light from the light source to the sample, a means for directing reflected light from the sample to a detector, at least one detector, a means for processing light data received by the detector and which generates an image; and an optical element having a transverse resolution defined as ..DELTA.ris less than or equal to about 5~m, and a depth of focus .DELTA.z of at least about 50 ~m.

Description

APPARATUS FOR LOW COHERENCE RANGING

FIELD OF THE INVENTION
The present invention relates to apparatus for imaging tissue samples using optical coherence tomography and incorporating an optical element to improve transverse resolution and depth of focus.

BACKGROUND
Currently the use of optical coherence tomography (OCT) is limited to the visualization of architectural morphological structures within biological tissues. The imaging of sub-cellular features with OCT has not been well demonstrated because of the relatively poor transverse resolution required to preserve depth of focus. The capability to perform high transverse resolution, large depth of field cross-sectional OCT imaging would permit application to early diagnosis of epithelial cancers and other biomedical imaging diagnostics that require sub-cellular level resolution.

To date, there are no known optical coherence tomography configurations that can perform high transverse resolution imaging over a large depth of field. It would be desirable to have a simple device for performing high transverse resolution, large depth of field optical coherence tomography. In addition, by allowing light delivery through a single optical fiber, this device would also be easily incorporated into catheters or endoscopes. These properties would make this device for performing optical coherence tomography in applications requiring sub-cellular resolution imaging at remote sites within biological systems.

SUMMARY

In accordance with a broad aspect, the invention provides an apparatus for imaging at least a portion of a sample. The apparatus comprises a first interferometric arrangement providing an electro-magnetic radiation. The apparatus also comprises a second arrangement configured to receive the electro-magnetic radiation, and configured to generate a resultant electro-magnetic intensity distribution, wherein, along a particular direction, the intensity distribution is approximately constant for at least a predetermined distance, and wherein a wavelength of the electro-magnetic radiation remains approximately the same for at least the predetermined distance at which the intensity distribution is approximately constant.

In accordance with another broad aspect, the invention provides an apparatus for imaging at least a portion of a sample. The apparatus comprises a first interferometric arrangement providing an electro-magnetic radiation and a second arrangement configured to receive the electro-magnetic radiation, and configured to generate a resultant electro-magnetic intensity distribution, wherein, along a particular direction, widths of at least two sections of the intensity distribution are approximately the same, and wherein a wavelength of the electro-magnetic radiation remains approximately the same for at least the at least two sections of the intensity distribution.

In accordance with yet another broad aspect, the invention provides a method for imaging at least a portion of a sample. The method comprises a) providing an electro-magnetic radiation using an interferometric arrangement; b) receiving the electro-magnetic radiation and generating a resultant electro-magnetic intensity distribution, wherein, along a particular direction, the intensity distribution is approximately constant for at least a predetermined distance, and wherein a wavelength of the electro-magnetic radiation remains approximately the same for at least the predetermined distance at which the intensity distribution is approximately constant.

In accordance with yet another broad aspect, the invention provides a method for imaging at least a portion of a sample. The method comprises (a) providing an electro-magnetic radiation using a interferometric arrangement; and (b) receiving the electro-magnetic radiation, and generating a resultant electro-magnetic intensity distribution, wherein, along a particular direction, widths of at least two sections of the intensity distribution are approximately the same, and wherein a wavelength of the electro-magnetic radiation remains approximately the same for at least the at least two sections of the intensity distribution.

BRIEF DESCRIPTION OF THE DRAWINGS

The invention is illustrated in the drawings in which like reference characters designate the same or similar parts throughout the figures of which:

Fig. 1 is a schematic view describing focusing using a refractive axicon. A
collimated beam, incident from the left, is focused to an axial line with a narrow width and a large depth.
Fig. 2 is a schematic view of an OCT system with axicon optic in sample arm.

Fig. 3 is a schematic view of the relationship between axial location and annulus of illumination.
Fig. 4A is a schematic view of the image formation.

Fig. 4B is a schematic view of the translation of the entire optical assembly in the y-direction.
Fig. 4C is a schematic view of the rotation of the entire optical assembly.
Fig. 4D is a schematic view of the angular deflection of the axial line focus in the x-y plane.
Fig. 5 is a schematic view of a system used to perform high transverse resolution ranging with a high depth of field.

Fig. 6 is a schematic view of an offset fiber array.

Fig. 7 is a schematic of a fiber array, microlens array and diffraction grating.
Fig. 8 is a schematic view of an embodiment of an apodized pupil plane filter.
Fig. 9 is a schematic view of the use of apodizer in front of an imaging lens.
DETAILED DESCRIPTION
Definitions "Axicon" shall mean any optic element (or combination thereof) capable of generating an axial line focus. Refractive, diffractive, and reflective axicons have been demonstrated.
See, J.H. McLeod, J. Opt. Soc. Am 44, 592 (1954); J.H. McLeod, J. Opt. Soc. Am 50, 166 (1960); and J.R. Rayces, J. Opt. Soc. Am. 48, 576 (1958).

"Depth of focus" shall mean the longitudinal distance over which the beam diameter increases by a factor ~ (typically = sqrt(2) or 2). For a Gaussian beam, the sqrt(2) depth of focus is:

2;T d 2zR (2) =

For a typical Gaussian spot size (1/e2 diameter) of d = 5 m, and a wavelength of 830nm, the depth of focus is approximately 48 m. The depth of focus for a uniform beam (3 dB
full-width-half-maximum intensity response for a planar reflector moved through the longitudinal plane) may be defined as .92 Zu Z NA2 For a NA = 0.2, which produces a spot size of 5 m, the depth of focus for a uniform beam is approximately 17 gm at 830 nm.

"Longitudinal" shall mean substantially parallel to the optical axis.

"Longitudinal resolution" shall mean the minimum distance, Az, in the longitudinal direction that two points may be separated while still being differentiated by an optical detection means.

"Spot size" shall mean the transverse diameter of a focused spot. For a Gaussian beam, the spot size is defined as transverse width of the spot where the intensity at the focus has decreased by a factor of 1/e2. For a collimated Gaussian beam, the spot size, d, is defined as d _ 4 Af where D is the beam diameter at the lens, f is the focal length of the lens and A is the wavelength. For a flat top or uniform beam, the spot radius is defined as the transverse position of the first zero of the Airy disk, 1.22/, 15 w= NA
where NA = n si tan ` )J , f and n is the refractive index of the immersion medium.

"Transverse" shall mean substantially perpendicular to the optical axis.

20 "Transverse resolution" shall mean the minimum distance, Ar, in the transverse direction that two points may be separated while still being differentiated by an optical detection means. One commonly used approximation is Ar = d (for a Gaussian beam) or Ar =
w (for a uniform beam).
Basic Principle An axial line focus, with a narrow transverse beam diameter and over a large length (or depth of focus), is generated. Used in conjunction with OCT, the diameter of the line focus determines the transverse resolution and the length determines the depth of field. As in standard OCT, the detection of light backreflected from sites along the axial focus is performed using a Michelson interferometer. When the light source has a finite spectral width, this configuration can be used to determine the axial location of the backreflection site. The axial resolution is determined by the coherence length of the light source.

Those of ordinary skill in the art will appreciate that there are a variety of known devices for generating a line focus. An axicon (reflective, transmissive, or diffractive optical element ("DOE")) is an acceptable model known to those skilled in the art for this and will be the method that is used in the present invention to demonstrate use of OCT with an axial line focus to achieve high resolution imaging over large depths of field. It is to be understood that this method is illustrative and not intended to be the exclusive model.
Other known models include, but are not limited to, multi-focal lenses, such as the Rayleigh-Wood lens (Optical Processing and Computing, H.H Arsenault, T.
Szoplik, and B. Macukow eds., Academic Press Inc., San Diego, CA, 1989), the use of chromatic aberration to produce an array of wavelength dependent foci along the longitudinal axis, and the like.

Resolution The following section discusses the physical principles of a representative axicon that uses refraction, as shown in Fig. 1. The intensity distribution of light transmitted through a refractive axicon lens (see R. Arimoto, C. Saloma, T. Tanaka, and S. Kawata, Appl.
Opt. 31, 6653 (1992)) is given by Equation (1):

I(r z) = 47t2E2(R) RSin(f3) J2 (27trSin(#)) (1) ' ,I Cost (f3) 0 A

where E2(R) is the intensity of the light incident on the axicon as a function of the radius R, A. is the wavelength of the light, and R is the half angle of the light transmitted through the axicon. The cone angle a is related to 0 and the depth of focus, ZD, by Equations (2a) and (2b):
nSin(a) = Sin(a+/3), (2a) zD = R(Cot(,J) - Tan(a)), (2b) where n is the refractive index of the axicon. The above equations can be used to determine the diameter of the axial line focus. For plane wave illumination the focus diameter is given by Equation (3):

do = 0.766 . (3) In the case of reflective or diffractive axicons, Equation (1) is modified, but in all cases it is the diameter of the axial focus that determines the transverse resolution of the imaging system. A theme of the present invention is that the poor transverse resolution typical of current OCT systems can be improved by changing from a standard focusing geometry in which the focal volume (power distribution) is limited in both the transverse and the axial dimensions to one in which the focal volume is limited only in the transverse direction.
By combining the high transverse localization (and weak axial localization) of an axicon with OCT (see Fig. 2), an imaging system that provides high three-dimensional localization over large field sizes can be realized. Axial resolution for this imaging technique is determined solely by the coherence length of the light source (E.A. Swanson, D. Huang, M.R. Hee, J.G. Fujimoto, C.P. Lin, and C.A. Puliafito, Opt. Lett.
17, 151 (1992)) and is given by Equation (4):

Az = 2Ln(2) ~z (4) r A2 where 0X is the spectral width (full-width half maximum ("FWHM"))of the light source.
In a preferred embodiment, the optical element has a transverse resolution defined as Ar=do being in the range of about 0.5 gm to about 10 gm, more preferably less than or equal to about 5 m. The optical element preferably has a Oz = zD of at least about 50 m.
Image Formation Fig. 4A illustrates the entire OCT/axicon system of one embodiment of the present invention. All components, other than the axicon probe, are standard to OCT.
The use of OCT to determine the backreflection as a function of distance along the axial line focus provides a one dimensional raster scan. This is typically accomplished by scanning the length of the interferometer reference arm. An axicon has the property each axial location of the focus corresponds to a unique annulus at the input aperture of the axicon (see Fig.
3). This relationship could allow the reference arm length scanning to be replaced by scanning an annulus of illumination at the axicon aperture.

Regardless of how the axial dimension is scanned, to obtain an image a scan of another axis must be performed. This second scanning dimension is usually performed at a slower rate. Methods of accomplishing this slow scanning of the secondary axis include moving the sample arm optics, including the optical fiber, collimating lens and axicon, in the y direction (see Fig. 4B), rotating the entire probe around the optical fiber axis (see Fig. 4C) or angularly deflecting the line focus in the x-y plane (see Fig. 4D). See, (G.J. Tearney, S.A. Boppart, B.E. Bouina, M.E. Brezinski, N.J. Weissman, J.F. Southern, and J.G.
Fujimoto, Opt. Lett. 21, 543 (1996)) and (S.A. Boppart, B.E. Bouma, C. Pitris, G.J.
Tearney, J.G. Fujimoto, and M.E. Brezinski, Opt. Lett. 22, 1618 (1997)). Both linear motion along the y or z axis and rotation are easily accomplished in a compact probe by use of piezoelectric transducers or mechanical or pneumatic actuators.

Fig. 5 is a schematic of an alternative apparatus used to perform high transverse resolution ranging with a high depth of field. The system comprises a light source, beam redirecting element, detector, and an optical element. The optical element provides line focus and an array of focused spots on the sample.

Fig. 6 shows an offset fiber array are directed by the mirror through the objective and used to displace focused (imaged) spots in the longitudinal and transverse dimensions on the sample. The spots are scanned (scan direction being indicated by the horizontal line and arrows) to create a multidimensional image.

Fig. 7 is a schematic of a fiber array, microlens array and diffraction grating (array of mirrors) used to displace focused (imaged) spots in the longitudinal and transverse dimensions on the sample. Light from the light source (not shown) passes through the fibers in the array, and through the microlens array to the diffraction grating. Light directed by the grating passes through the objective lens and focused on the sample. The spots are scanned (scan direction being indicated by the horizontal line and arrows) to create a multidimensional image.

An alternative means for providing a high transverse resolution over a large depth of focus is the use of a filter in the back plane of the imaging lens. This technique, commonly termed apodization, allows the production of either a line focus as in the axicon or a multitude of focused spots positioned along the longitudinal dimension. The use of annular apodization to shape a beam focus has been previously described in the literature (M. Martinez-Corral, P. Andres, J. Ojeda-Castaneda, G. Saavedra, Opt. Comm.
119, 491 (1995)). However, use of apodization to create high transverse resolution over a large focal distance, where the longitudinal data is further resolved by OCT
has not been previously described.

Fig. 8 shows an embodiment of an apodized pupil plane filter.

Fig. 9 shows a schematic of the use of an apodizer in front of an imaging lens the output of which is focused in the axial line.

METHOD OF IMAGING

The present invention also provides a method of obtaining a high resolution and high depth of focus image of a sample, comprising:

a. providing a light source;

b. directing light from said light source through an optical element to a sample by a light directing means, the optical element having a transverse resolution of less than about 5 gm and a depth of focus of greater than about 50 gm;

c. receiving reflected light from the sample back through said optical element;

d. directing said reflected light to a detector; and, e. processing the data from the detector to produce an image An advantage of the present invention is that the OCT imaging apparatus is capable of enabling sub-cellular resolution imaging along transverse and longitudinal dimensions of the sample in a compact, optical fiber-based package. Other advantages include the potential compact size and low cost of axial line focus optical elements such as the apodizer-lens combination or axicon.

Although only a few exemplary embodiments of this invention have been described in detail above, those skilled in the art will readily appreciate that many modifications are possible in the exemplary embodiments without materially departing from the novel teachings and ' advantages of this invention. Accordingly, all such modifications are intended to be included within the scope of this invention as defined in the following claims. It should fu ther be noted that any patents, applications and publications referred to herein are incorporated by reference in their entirety.

Claims (50)

CLAIMS:
1. An apparatus for imaging at least a portion of a sample, comprising:
a first interferometric arrangement providing an electro-magnetic radiation;
and a second arrangement configured to receive the electro-magnetic radiation, and configured to generate a resultant electro-magnetic intensity distribution, wherein, along a particular direction, the intensity distribution is approximately constant for at least a predetermined distance, and wherein a wavelength of the electro-magnetic radiation remains approximately the same for at least the predetermined distance at which the intensity distribution is approximately constant.
2. The apparatus according to claim 1, wherein the second arrangement is an optical arrangement which is configured to optically image the sample.
3. The apparatus according to claim 1, wherein the second arrangement is an axicon lens.
4. The apparatus according to claim 1, wherein the second arrangement is a defractive optical element.
5. The apparatus according to claim 1, wherein the second arrangement is an annulus.
6. The apparatus according to claim 1, wherein the second arrangement includes a combination of a diffractive element and a lens.
7. The apparatus according to claim 1, wherein the second arrangement includes an apodized lens or a diffractive element.
8. The apparatus according to claim 1, wherein the intensity distribution is a Bessel beam.
9. The apparatus according to claim 1, further comprising a third arrangement adapted to cooperate with the second arrangement so as to translate at least one of the intensity distribution and the sample.
10. The apparatus according to claim 9, wherein a translation of the at least one of the intensity distribution and the sample produces an image which has 2 or more dimensions.
11. The apparatus according to claim 1, wherein the intensity distribution having a transverse resolution of a full width at half maximum is less than 10µm.
12. The apparatus according to claim 1, wherein the predetermined distance is at least 50µm.
13. The apparatus according to claim 1, wherein at least a portion of the intensity distribution includes a non-Gaussian distribution.
14. The apparatus according to claim 1, further comprising a fourth arrangement configured to received information that is associated with the intensity distribution, and display an image based on the received information.
15. An apparatus for imaging at least a portion of a sample, comprising:
a first interferometric arrangement providing an electro-magnetic radiation;
and a second arrangement configured to receive the electro-magnetic radiation, and configured to generate a resultant electro-magnetic intensity distribution, wherein, along a particular direction, widths of at least two sections of the intensity distribution are approximately the same, and wherein a wavelength of the electro-magnetic radiation remains approximately the same for at least the at least two sections of the intensity distribution.
16. The apparatus according to claim 15, wherein the particular direction is approximately a vertical direction.
17. The apparatus according to claim 15, wherein the second arrangement includes a plurality of lenses.
18. The apparatus according to claim 15, wherein one of the sections is at least partially above another one of the sections.
19. The apparatus according to claim 15, wherein the intensity distribution having a transverse resolution of a full width at half maximum is less than 10µm.
20. The apparatus according to claim 15, wherein at least a portion of the intensity distribution includes a non-Gaussian distribution.
21. The apparatus according to claim 15, further comprising a third arrangement adapted to cooperate with the second arrangement so as to translate at least one of the intensity distribution and the sample.
22. The apparatus according to claim 21, wherein a translation of the at least one of the intensity distribution and the sample produces an image which has 2 or more dimensions.
23. A method for imaging at least a portion of a sample, comprising:
a) providing an electro-magnetic radiation using an interferometric arrangement;
b) receiving the electro-magnetic radiation and generating a resultant electro-magnetic intensity distribution, wherein, along a particular direction, the intensity distribution is approximately constant for at least a predetermined distance, and wherein a wavelength of the electro-magnetic radiation remains approximately the same for at least the predetermined distance at which the intensity distribution is approximately constant.
24. The method according to claim 23, wherein step (b) is performed using an optical arrangement which is configured to optically image the sample.
25. The method according to claim 23, wherein step (b) is performed using an axicon lens.
26. The method according to claim 23, wherein step (b) is performed using a defractive optical element.
27. The method according to claim 23, wherein step (b) is performed using an annulus.
28. The method according to claim 23, wherein step (b) is performed using a combination of a diffractive element and a lens.
29. The method according to claim 23, wherein step (b) is performed using an apodized lens or a diffractive element.
30. The method according to claim 23, wherein the intensity distribution is a Bessel beam.
31. The method according to claim 23, further comprising translating at least one of the intensity distribution and the sample.
32. The method according to claim 31, wherein a translation of the at least one of the intensity distribution and the sample produces an image which has 2 or more dimensions.
33. The method according to claim 23, wherein the intensity distribution having a transverse resolution of a full width at half maximum is less than 10µm.
34. The method according to claim 23, wherein the predetermined distance is at least 50µm.
35. The method according to claim 23, wherein at least a portion of the intensity distribution includes a non-Gaussian distribution.
36. The method according to claim 23, further comprising the steps of receiving information that is associated with the intensity distribution; and displaying an image based on the received information.
37. A method for imaging at least a portion of a sample, comprising:
(a) providing an electro-magnetic radiation using a interferometric arrangement;
and (b) receiving the electro-magnetic radiation, and generating a resultant electro-magnetic intensity distribution, wherein, along a particular direction, widths of at least two sections of the intensity distribution are approximately the same, and wherein a wavelength of the electro-magnetic radiation remains approximately the same for at least the at least two sections of the intensity distribution.
38. The method according to claim 37, wherein step (b) is performed using an optical arrangement which is configured to optically image the sample.
39. The method according to claim 37, wherein step (b) is performed using an axicon lens.
40. The method according to claim 37, wherein step (b) is performed using a defractive optical element.
41. The method according to claim 37, wherein step (b) is performed using an annulus.
42. The method according to claim 37, wherein step (b) is performed using a combination of a diffractive element and a lens.
43. The method according to claim 37, wherein step (b) is performed using an apodized lens or a diffractive element.
44. The method according to claim 37, wherein the intensity distribution is a Bessel beam.
45. The method according to claim 37, further comprising translating at least one of the intensity distribution and the sample.
46. The method according to claim 45, wherein a translation of the at least one of the intensity distribution and the sample produces an image which has 2 or more dimensions.
47. The method according to claim 37, wherein the intensity distribution having a transverse resolution of a full width at half maximum is less than 10µm.
48. The method according to claim 37, wherein the predetermined distance is at least 50µm.
49. The method according to claim 37, wherein at least a portion of the intensity distribution includes a non-Gaussian distribution.
50. The method according to claim 37, further comprising the steps of receiving information that is associated with the intensity distribution; and displaying an image based on the received information.
CA2473465A 2002-01-11 2003-01-10 Apparatus for low coherence ranging Expired - Fee Related CA2473465C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US34752802P 2002-01-11 2002-01-11
US60/347,528 2002-01-11
PCT/US2003/000699 WO2003060423A2 (en) 2002-01-11 2003-01-10 Apparatus for low coherence ranging

Publications (2)

Publication Number Publication Date
CA2473465A1 CA2473465A1 (en) 2003-07-24
CA2473465C true CA2473465C (en) 2011-04-05

Family

ID=32987184

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2473465A Expired - Fee Related CA2473465C (en) 2002-01-11 2003-01-10 Apparatus for low coherence ranging

Country Status (9)

Country Link
US (1) US7310150B2 (en)
EP (4) EP1468245B1 (en)
JP (1) JP2005530128A (en)
CN (2) CN1639539A (en)
AT (1) ATE503982T1 (en)
AU (2) AU2003207507A1 (en)
CA (1) CA2473465C (en)
DE (1) DE60336534D1 (en)
WO (1) WO2003060423A2 (en)

Families Citing this family (233)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP4241038B2 (en) 2000-10-30 2009-03-18 ザ ジェネラル ホスピタル コーポレーション Optical method and system for tissue analysis
US9295391B1 (en) 2000-11-10 2016-03-29 The General Hospital Corporation Spectrally encoded miniature endoscopic imaging probe
AT411269B (en) * 2001-11-05 2003-11-25 Salzburger Aluminium Ag ALUMINUM-SILICON ALLOYS WITH IMPROVED MECHANICAL PROPERTIES
US7761139B2 (en) * 2003-01-24 2010-07-20 The General Hospital Corporation System and method for identifying tissue using low-coherence interferometry
EP2436307B1 (en) 2003-03-31 2015-10-21 The General Hospital Corporation Speckle reduction in optical coherence tomography by path length encoded angular compounding
EP2280260B1 (en) 2003-06-06 2017-03-08 The General Hospital Corporation Process and apparatus for a wavelength tuned light source
EP3045136B1 (en) 2003-09-12 2021-02-24 Vessix Vascular, Inc. Selectable eccentric remodeling and/or ablation of atherosclerotic material
JP5567246B2 (en) 2003-10-27 2014-08-06 ザ ジェネラル ホスピタル コーポレイション Method and apparatus for performing optical imaging using frequency domain interferometry
US7447408B2 (en) 2004-07-02 2008-11-04 The General Hospital Corproation Imaging system and related techniques
EP1782020B1 (en) 2004-08-06 2012-10-03 The General Hospital Corporation Process, system and software arrangement for determining at least one location in a sample using an optical coherence tomography
US8965487B2 (en) * 2004-08-24 2015-02-24 The General Hospital Corporation Process, system and software arrangement for measuring a mechanical strain and elastic properties of a sample
EP1793731B1 (en) * 2004-08-24 2013-12-25 The General Hospital Corporation Imaging apparatus comprising a fluid delivery arrangement and a pull-back arrangement
US8396548B2 (en) 2008-11-14 2013-03-12 Vessix Vascular, Inc. Selective drug delivery in a lumen
US9713730B2 (en) 2004-09-10 2017-07-25 Boston Scientific Scimed, Inc. Apparatus and method for treatment of in-stent restenosis
US8920414B2 (en) 2004-09-10 2014-12-30 Vessix Vascular, Inc. Tuned RF energy and electrical tissue characterization for selective treatment of target tissues
KR101257100B1 (en) 2004-09-29 2013-04-22 더 제너럴 하스피탈 코포레이션 System and Method for Optical Coherence Imaging
JP2008521516A (en) * 2004-11-29 2008-06-26 ザ ジェネラル ホスピタル コーポレイション Configuration, apparatus, endoscope, catheter, and method for performing optical image generation by simultaneously illuminating and detecting multiple points on a sample
EP1850735A2 (en) * 2005-02-10 2007-11-07 Lightlab Imaging, Inc. Optical coherence tomography apparatus and methods
US20070038040A1 (en) * 2005-04-22 2007-02-15 The General Hospital Corporation Arrangements, systems and methods capable of providing spectral-domain polarization-sensitive optical coherence tomography
US8351665B2 (en) 2005-04-28 2013-01-08 The General Hospital Corporation Systems, processes and software arrangements for evaluating information associated with an anatomical structure by an optical coherence ranging technique
JP5702049B2 (en) * 2005-06-01 2015-04-15 ザ ジェネラル ホスピタル コーポレイション Apparatus, method and system for performing phase resolved optical frequency domain imaging
EP2267404B1 (en) * 2005-08-09 2016-10-05 The General Hospital Corporation Apparatus and method for performing polarization-based quadrature demodulation in optical coherence tomography
US8784336B2 (en) 2005-08-24 2014-07-22 C. R. Bard, Inc. Stylet apparatuses and methods of manufacture
EP1937137B1 (en) 2005-09-29 2022-06-15 General Hospital Corporation Method and apparatus for optical imaging via spectral encoding
JP2009523574A (en) * 2006-01-18 2009-06-25 ザ ジェネラル ホスピタル コーポレイション System and method for generating data using one or more endoscopic microscopy methods
US8145018B2 (en) 2006-01-19 2012-03-27 The General Hospital Corporation Apparatus for obtaining information for a structure using spectrally-encoded endoscopy techniques and methods for producing one or more optical arrangements
WO2007084995A2 (en) 2006-01-19 2007-07-26 The General Hospital Corporation Methods and systems for optical imaging of epithelial luminal organs by beam scanning thereof
US20090128824A1 (en) * 2006-01-24 2009-05-21 Rainer Leitgeb Optical imaging system with extended depth of focus
JP4483793B2 (en) * 2006-01-27 2010-06-16 セイコーエプソン株式会社 Microstructure manufacturing method and manufacturing apparatus
JP5524487B2 (en) 2006-02-01 2014-06-18 ザ ジェネラル ホスピタル コーポレイション A method and system for emitting electromagnetic radiation to at least a portion of a sample using a conformal laser treatment procedure.
WO2007149603A2 (en) 2006-02-01 2007-12-27 The General Hospital Corporation Apparatus for applying a plurality of electro-magnetic radiations to a sample
EP2306141A1 (en) 2006-02-24 2011-04-06 The General Hospital Corporation Methods and systems for performing angle-resolved fourier-domain optical coherence tomography
US8019435B2 (en) 2006-05-02 2011-09-13 Boston Scientific Scimed, Inc. Control of arterial smooth muscle tone
WO2007133961A2 (en) 2006-05-10 2007-11-22 The General Hospital Corporation Processes, arrangements and systems for providing frequency domain imaging of a sample
US20080024767A1 (en) * 2006-07-28 2008-01-31 Peter Seitz Imaging optical coherence tomography with dynamic coherent focus
US20100165335A1 (en) * 2006-08-01 2010-07-01 The General Hospital Corporation Systems and methods for receiving and/or analyzing information associated with electro-magnetic radiation
CN100401974C (en) * 2006-09-08 2008-07-16 浙江大学 Method and system for realizing axial super resolution in tomography of optical coherent
EP2076194B1 (en) 2006-10-18 2013-04-24 Vessix Vascular, Inc. System for inducing desirable temperature effects on body tissue
EP2992850A1 (en) 2006-10-18 2016-03-09 Vessix Vascular, Inc. Inducing desirable temperature effects on body tissue
WO2008049118A2 (en) 2006-10-19 2008-04-24 The General Hospital Corporation Apparatus and method for obtaining and providing imaging information associated with at least one portion of a sample and effecting such portion(s)
US8388546B2 (en) 2006-10-23 2013-03-05 Bard Access Systems, Inc. Method of locating the tip of a central venous catheter
US7794407B2 (en) 2006-10-23 2010-09-14 Bard Access Systems, Inc. Method of locating the tip of a central venous catheter
US20080118886A1 (en) * 2006-11-21 2008-05-22 Rongguang Liang Apparatus for dental oct imaging
US8360963B2 (en) * 2006-12-22 2013-01-29 Koninklijke Philips Electronics N.V. Imaging system with two imaging modalities
WO2008089342A1 (en) * 2007-01-19 2008-07-24 The General Hospital Corporation Rotating disk reflection for fast wavelength scanning of dispersed broadband light
WO2008115965A1 (en) * 2007-03-19 2008-09-25 The General Hospital Corporation Apparatus and method for providing a noninvasive diagnosis of internal bleeding
US10534129B2 (en) 2007-03-30 2020-01-14 The General Hospital Corporation System and method providing intracoronary laser speckle imaging for the detection of vulnerable plaque
EP2194903B1 (en) 2007-09-06 2017-10-25 Alcon LenSx, Inc. Precise targeting of surgical photodisruption
US20090073439A1 (en) * 2007-09-15 2009-03-19 The General Hospital Corporation Apparatus, computer-accessible medium and method for measuring chemical and/or molecular compositions of coronary atherosclerotic plaques in anatomical structures
EP2040059A3 (en) * 2007-09-19 2013-09-04 FUJIFILM Corporation Optical tomography imaging system, contact area detecting method and image processing method using the same, and optical tomographic image obtaining method
US8781555B2 (en) 2007-11-26 2014-07-15 C. R. Bard, Inc. System for placement of a catheter including a signal-generating stylet
US9649048B2 (en) 2007-11-26 2017-05-16 C. R. Bard, Inc. Systems and methods for breaching a sterile field for intravascular placement of a catheter
US10524691B2 (en) 2007-11-26 2020-01-07 C. R. Bard, Inc. Needle assembly including an aligned magnetic element
US9521961B2 (en) 2007-11-26 2016-12-20 C. R. Bard, Inc. Systems and methods for guiding a medical instrument
US10449330B2 (en) 2007-11-26 2019-10-22 C. R. Bard, Inc. Magnetic element-equipped needle assemblies
EP2992825B1 (en) 2007-11-26 2017-11-01 C.R. Bard Inc. Integrated system for intravascular placement of a catheter
US8849382B2 (en) 2007-11-26 2014-09-30 C. R. Bard, Inc. Apparatus and display methods relating to intravascular placement of a catheter
US10751509B2 (en) 2007-11-26 2020-08-25 C. R. Bard, Inc. Iconic representations for guidance of an indwelling medical device
US9456766B2 (en) 2007-11-26 2016-10-04 C. R. Bard, Inc. Apparatus for use with needle insertion guidance system
US20090225324A1 (en) * 2008-01-17 2009-09-10 The General Hospital Corporation Apparatus for providing endoscopic high-speed optical coherence tomography
US11123047B2 (en) 2008-01-28 2021-09-21 The General Hospital Corporation Hybrid systems and methods for multi-modal acquisition of intravascular imaging data and counteracting the effects of signal absorption in blood
US8478382B2 (en) 2008-02-11 2013-07-02 C. R. Bard, Inc. Systems and methods for positioning a catheter
JP5607610B2 (en) 2008-05-07 2014-10-15 ザ ジェネラル ホスピタル コーポレイション Apparatus for determining structural features, method of operating apparatus and computer-accessible medium
US9254089B2 (en) 2008-07-14 2016-02-09 The General Hospital Corporation Apparatus and methods for facilitating at least partial overlap of dispersed ration on at least one sample
EP2313143B1 (en) 2008-08-22 2014-09-24 C.R. Bard, Inc. Catheter assembly including ecg sensor and magnetic assemblies
US8437833B2 (en) 2008-10-07 2013-05-07 Bard Access Systems, Inc. Percutaneous magnetic gastrostomy
US9795442B2 (en) 2008-11-11 2017-10-24 Shifamed Holdings, Llc Ablation catheters
WO2010056771A1 (en) 2008-11-11 2010-05-20 Shifamed Llc Low profile electrode assembly
CA2743992A1 (en) 2008-11-17 2010-05-20 Minnow Medical, Inc. Selective accumulation of energy with or without knowledge of tissue topography
US9532724B2 (en) 2009-06-12 2017-01-03 Bard Access Systems, Inc. Apparatus and method for catheter navigation using endovascular energy mapping
US9125578B2 (en) 2009-06-12 2015-09-08 Bard Access Systems, Inc. Apparatus and method for catheter navigation and tip location
US9339206B2 (en) 2009-06-12 2016-05-17 Bard Access Systems, Inc. Adaptor for endovascular electrocardiography
WO2010151698A2 (en) 2009-06-24 2010-12-29 Shifamed, Llc Steerable medical delivery devices and methods of use
EP2453791B1 (en) * 2009-07-14 2023-09-06 The General Hospital Corporation Apparatus for measuring flow and pressure within a vessel
EP2464407A4 (en) 2009-08-10 2014-04-02 Bard Access Systems Inc Devices and methods for endovascular electrography
EP2517622A3 (en) 2009-09-29 2013-04-24 C. R. Bard, Inc. Stylets for use with apparatus for intravascular placement of a catheter
US8937723B2 (en) * 2009-10-01 2015-01-20 Thunder Bay Regional Research Institute Apparatus and methods for optical coherence tomography and confocal microscopy
WO2011044421A1 (en) 2009-10-08 2011-04-14 C. R. Bard, Inc. Spacers for use with an ultrasound probe
WO2011047053A2 (en) * 2009-10-13 2011-04-21 California Institute Of Technology Holographically illuminated imaging devices
US9492322B2 (en) 2009-11-16 2016-11-15 Alcon Lensx, Inc. Imaging surgical target tissue by nonlinear scanning
US8860948B2 (en) * 2010-01-22 2014-10-14 Ben Gurion University of the Negev Research and Development Authority Ltd.; Bar Ilan University High resolution extended depth of field optical coherence tomography
US8265364B2 (en) 2010-02-05 2012-09-11 Alcon Lensx, Inc. Gradient search integrated with local imaging in laser surgical systems
US8414564B2 (en) 2010-02-18 2013-04-09 Alcon Lensx, Inc. Optical coherence tomographic system for ophthalmic surgery
US8970671B2 (en) * 2010-02-23 2015-03-03 California Institute Of Technology Nondiffracting beam detection devices for three-dimensional imaging
SI2542145T1 (en) 2010-03-05 2021-01-29 The General Hospital Corporation Systems which provide microscopic images of at least one anatomical structure at a particular resolution
CA2793737A1 (en) 2010-03-24 2011-09-29 Shifamed Holdings, Llc Intravascular tissue disruption
CN103068330B (en) 2010-04-09 2016-06-29 Vessix血管股份有限公司 Power for treating tissue occurs and controls device
US9192790B2 (en) 2010-04-14 2015-11-24 Boston Scientific Scimed, Inc. Focused ultrasonic renal denervation
US9069130B2 (en) 2010-05-03 2015-06-30 The General Hospital Corporation Apparatus, method and system for generating optical radiation from biological gain media
EP2568905A4 (en) 2010-05-12 2017-07-26 Shifamed Holdings, LLC Low profile electrode assembly
US9655677B2 (en) 2010-05-12 2017-05-23 Shifamed Holdings, Llc Ablation catheters including a balloon and electrodes
EP2575598A2 (en) 2010-05-25 2013-04-10 The General Hospital Corporation Apparatus, systems, methods and computer-accessible medium for spectral analysis of optical coherence tomography images
WO2011149972A2 (en) 2010-05-25 2011-12-01 The General Hospital Corporation Systems, devices, methods, apparatus and computer-accessible media for providing optical imaging of structures and compositions
EP4122385A1 (en) 2010-05-28 2023-01-25 C. R. Bard, Inc. Insertion guidance system for needles and medical components
WO2011153434A2 (en) 2010-06-03 2011-12-08 The General Hospital Corporation Apparatus and method for devices for imaging structures in or at one or more luminal organs
US8473067B2 (en) 2010-06-11 2013-06-25 Boston Scientific Scimed, Inc. Renal denervation and stimulation employing wireless vascular energy transfer arrangement
US8398236B2 (en) 2010-06-14 2013-03-19 Alcon Lensx, Inc. Image-guided docking for ophthalmic surgical systems
US9463062B2 (en) 2010-07-30 2016-10-11 Boston Scientific Scimed, Inc. Cooled conductive balloon RF catheter for renal nerve ablation
US9084609B2 (en) 2010-07-30 2015-07-21 Boston Scientific Scime, Inc. Spiral balloon catheter for renal nerve ablation
US9358365B2 (en) 2010-07-30 2016-06-07 Boston Scientific Scimed, Inc. Precision electrode movement control for renal nerve ablation
US9155589B2 (en) 2010-07-30 2015-10-13 Boston Scientific Scimed, Inc. Sequential activation RF electrode set for renal nerve ablation
US9408661B2 (en) 2010-07-30 2016-08-09 Patrick A. Haverkost RF electrodes on multiple flexible wires for renal nerve ablation
CA2806353A1 (en) 2010-08-09 2012-02-16 C.R. Bard Inc. Support and cover structures for an ultrasound probe head
KR101856267B1 (en) 2010-08-20 2018-05-09 씨. 알. 바드, 인크. Reconfirmation of ecg-assisted catheter tip placement
US8536545B2 (en) 2010-09-09 2013-09-17 California Institute Of Technology Delayed emission detection devices and methods
US9532708B2 (en) 2010-09-17 2017-01-03 Alcon Lensx, Inc. Electronically controlled fixation light for ophthalmic imaging systems
US8974451B2 (en) 2010-10-25 2015-03-10 Boston Scientific Scimed, Inc. Renal nerve ablation using conductive fluid jet and RF energy
US9220558B2 (en) 2010-10-27 2015-12-29 Boston Scientific Scimed, Inc. RF renal denervation catheter with multiple independent electrodes
EP2632324A4 (en) 2010-10-27 2015-04-22 Gen Hospital Corp Apparatus, systems and methods for measuring blood pressure within at least one vessel
US8801693B2 (en) 2010-10-29 2014-08-12 C. R. Bard, Inc. Bioimpedance-assisted placement of a medical device
JP5535043B2 (en) * 2010-11-08 2014-07-02 三菱電機株式会社 Resin identification device
US9028485B2 (en) 2010-11-15 2015-05-12 Boston Scientific Scimed, Inc. Self-expanding cooling electrode for renal nerve ablation
US9089350B2 (en) 2010-11-16 2015-07-28 Boston Scientific Scimed, Inc. Renal denervation catheter with RF electrode and integral contrast dye injection arrangement
US9668811B2 (en) 2010-11-16 2017-06-06 Boston Scientific Scimed, Inc. Minimally invasive access for renal nerve ablation
US9326751B2 (en) 2010-11-17 2016-05-03 Boston Scientific Scimed, Inc. Catheter guidance of external energy for renal denervation
US9060761B2 (en) 2010-11-18 2015-06-23 Boston Scientific Scime, Inc. Catheter-focused magnetic field induced renal nerve ablation
US9023034B2 (en) 2010-11-22 2015-05-05 Boston Scientific Scimed, Inc. Renal ablation electrode with force-activatable conduction apparatus
US9192435B2 (en) 2010-11-22 2015-11-24 Boston Scientific Scimed, Inc. Renal denervation catheter with cooled RF electrode
US20120157993A1 (en) 2010-12-15 2012-06-21 Jenson Mark L Bipolar Off-Wall Electrode Device for Renal Nerve Ablation
US9220561B2 (en) 2011-01-19 2015-12-29 Boston Scientific Scimed, Inc. Guide-compatible large-electrode catheter for renal nerve ablation with reduced arterial injury
US9999354B2 (en) * 2011-01-21 2018-06-19 National Research Council Of Canada Biological tissue inspection method and system
US9086536B2 (en) 2011-03-09 2015-07-21 California Institute Of Technology Talbot imaging devices and systems
JP5610063B2 (en) * 2011-03-24 2014-10-22 株式会社ニコン Observation apparatus and observation method
US8946619B2 (en) 2011-04-20 2015-02-03 California Institute Of Technology Talbot-illuminated imaging devices, systems, and methods for focal plane tuning
US9179843B2 (en) 2011-04-21 2015-11-10 Hassan Ghaderi MOGHADDAM Method and system for optically evaluating proximity to the inferior alveolar nerve in situ
US8459794B2 (en) 2011-05-02 2013-06-11 Alcon Lensx, Inc. Image-processor-controlled misalignment-reduction for ophthalmic systems
AU2012250729B2 (en) 2011-05-03 2016-12-01 Shifamed Holdings, Llc Steerable delivery sheaths
US9622913B2 (en) 2011-05-18 2017-04-18 Alcon Lensx, Inc. Imaging-controlled laser surgical system
AU2012278809B2 (en) 2011-07-06 2016-09-29 C.R. Bard, Inc. Needle length determination and calibration for insertion guidance system
TWI447352B (en) * 2011-07-08 2014-08-01 私立中原大學 Optical tomography system
WO2013013049A1 (en) 2011-07-19 2013-01-24 The General Hospital Corporation Systems, methods, apparatus and computer-accessible-medium for providing polarization-mode dispersion compensation in optical coherence tomography
CN103813745B (en) 2011-07-20 2016-06-29 波士顿科学西美德公司 In order to visualize, be directed at and to melt transcutaneous device and the method for nerve
CN103813829B (en) 2011-07-22 2016-05-18 波士顿科学西美德公司 There is the neuromodulation system of the neuromodulation element that can be positioned in spiral guiding piece
USD724745S1 (en) 2011-08-09 2015-03-17 C. R. Bard, Inc. Cap for an ultrasound probe
USD699359S1 (en) 2011-08-09 2014-02-11 C. R. Bard, Inc. Ultrasound probe head
EP3835718B1 (en) 2011-08-25 2023-07-26 The General Hospital Corporation Apparatus for providing micro-optical coherence tomography inside a respiratory system
US8398238B1 (en) 2011-08-26 2013-03-19 Alcon Lensx, Inc. Imaging-based guidance system for ophthalmic docking using a location-orientation analysis
WO2013055826A1 (en) 2011-10-10 2013-04-18 Boston Scientific Scimed, Inc. Medical devices including ablation electrodes
US9420955B2 (en) 2011-10-11 2016-08-23 Boston Scientific Scimed, Inc. Intravascular temperature monitoring system and method
US10085799B2 (en) 2011-10-11 2018-10-02 Boston Scientific Scimed, Inc. Off-wall electrode device and methods for nerve modulation
US9364284B2 (en) 2011-10-12 2016-06-14 Boston Scientific Scimed, Inc. Method of making an off-wall spacer cage
US9341783B2 (en) 2011-10-18 2016-05-17 The General Hospital Corporation Apparatus and methods for producing and/or providing recirculating optical delay(s)
EP2768563B1 (en) 2011-10-18 2016-11-09 Boston Scientific Scimed, Inc. Deflectable medical devices
EP2768568B1 (en) 2011-10-18 2020-05-06 Boston Scientific Scimed, Inc. Integrated crossing balloon catheter
WO2013070775A1 (en) 2011-11-07 2013-05-16 C.R. Bard, Inc Ruggedized ultrasound hydrogel insert
CN108095821B (en) 2011-11-08 2021-05-25 波士顿科学西美德公司 Orifice renal nerve ablation
US9119600B2 (en) 2011-11-15 2015-09-01 Boston Scientific Scimed, Inc. Device and methods for renal nerve modulation monitoring
US9119632B2 (en) 2011-11-21 2015-09-01 Boston Scientific Scimed, Inc. Deflectable renal nerve ablation catheter
US9023016B2 (en) 2011-12-19 2015-05-05 Alcon Lensx, Inc. Image processor for intra-surgical optical coherence tomographic imaging of laser cataract procedures
US9066784B2 (en) 2011-12-19 2015-06-30 Alcon Lensx, Inc. Intra-surgical optical coherence tomographic imaging of cataract procedures
US20130163003A1 (en) * 2011-12-21 2013-06-27 Ole Massow Apparatus and method for optical swept-source coherence tomography
US9265969B2 (en) 2011-12-21 2016-02-23 Cardiac Pacemakers, Inc. Methods for modulating cell function
EP2793724B1 (en) 2011-12-23 2016-10-12 Vessix Vascular, Inc. Apparatuses for remodeling tissue of or adjacent to a body passage
CN104135958B (en) 2011-12-28 2017-05-03 波士顿科学西美德公司 By the apparatus and method that have the new ablation catheter modulation nerve of polymer ablation
US9050106B2 (en) 2011-12-29 2015-06-09 Boston Scientific Scimed, Inc. Off-wall electrode device and methods for nerve modulation
JP5655805B2 (en) * 2012-03-21 2015-01-21 住友電気工業株式会社 Optical probe and optical measurement method
US9629528B2 (en) 2012-03-30 2017-04-25 The General Hospital Corporation Imaging system, method and distal attachment for multidirectional field of view endoscopy
US8961550B2 (en) 2012-04-17 2015-02-24 Indian Wells Medical, Inc. Steerable endoluminal punch
WO2013169927A1 (en) 2012-05-08 2013-11-14 Boston Scientific Scimed, Inc. Renal nerve modulation devices
EP2852315A4 (en) 2012-05-21 2016-06-08 Gen Hospital Corp Apparatus, device and method for capsule microscopy
CN104837413B (en) 2012-06-15 2018-09-11 C·R·巴德股份有限公司 Detect the device and method of removable cap on ultrasonic detector
JP5828811B2 (en) * 2012-07-23 2015-12-09 キヤノン株式会社 Imaging apparatus and control method thereof
EP2690395A1 (en) * 2012-07-24 2014-01-29 Hexagon Technology Center GmbH Interferometric distance measuring assembly and method
EP2888616A4 (en) 2012-08-22 2016-04-27 Gen Hospital Corp System, method, and computer-accessible medium for fabrication minature endoscope using soft lithography
CN104540465A (en) 2012-08-24 2015-04-22 波士顿科学西美德公司 Intravascular catheter with a balloon comprising separate microporous regions
CN104780859B (en) 2012-09-17 2017-07-25 波士顿科学西美德公司 Self-positioning electrode system and method for renal regulation
WO2014047411A1 (en) 2012-09-21 2014-03-27 Boston Scientific Scimed, Inc. System for nerve modulation and innocuous thermal gradient nerve block
US10549127B2 (en) 2012-09-21 2020-02-04 Boston Scientific Scimed, Inc. Self-cooling ultrasound ablation catheter
US10835305B2 (en) 2012-10-10 2020-11-17 Boston Scientific Scimed, Inc. Renal nerve modulation devices and methods
US9677869B2 (en) 2012-12-05 2017-06-13 Perimeter Medical Imaging, Inc. System and method for generating a wide-field OCT image of a portion of a sample
KR20140089129A (en) 2013-01-04 2014-07-14 삼성전자주식회사 Optical zoom probe
JP6053138B2 (en) * 2013-01-24 2016-12-27 株式会社日立エルジーデータストレージ Optical tomographic observation apparatus and optical tomographic observation method
US9968261B2 (en) 2013-01-28 2018-05-15 The General Hospital Corporation Apparatus and method for providing diffuse spectroscopy co-registered with optical frequency domain imaging
WO2014120791A1 (en) 2013-01-29 2014-08-07 The General Hospital Corporation Apparatus, systems and methods for providing information regarding the aortic valve
WO2014121082A1 (en) 2013-02-01 2014-08-07 The General Hospital Corporation Objective lens arrangement for confocal endomicroscopy
US9693821B2 (en) 2013-03-11 2017-07-04 Boston Scientific Scimed, Inc. Medical devices for modulating nerves
WO2014163987A1 (en) 2013-03-11 2014-10-09 Boston Scientific Scimed, Inc. Medical devices for modulating nerves
US9808311B2 (en) 2013-03-13 2017-11-07 Boston Scientific Scimed, Inc. Deflectable medical devices
EP2967491B1 (en) 2013-03-15 2022-05-11 The General Hospital Corporation A transesophageal endoscopic system for determining a mixed venous oxygen saturation of a pulmonary artery
JP6220044B2 (en) 2013-03-15 2017-10-25 ボストン サイエンティフィック サイムド，インコーポレイテッドＢｏｓｔｏｎ Ｓｃｉｅｎｔｉｆｉｃ Ｓｃｉｍｅｄ，Ｉｎｃ． Medical device for renal nerve ablation
US9297845B2 (en) 2013-03-15 2016-03-29 Boston Scientific Scimed, Inc. Medical devices and methods for treatment of hypertension that utilize impedance compensation
US10265122B2 (en) 2013-03-15 2019-04-23 Boston Scientific Scimed, Inc. Nerve ablation devices and related methods of use
EP2968919B1 (en) 2013-03-15 2021-08-25 Medtronic Ardian Luxembourg S.à.r.l. Controlled neuromodulation systems
CA2908517A1 (en) 2013-04-08 2014-10-16 Apama Medical, Inc. Cardiac ablation catheters and methods of use thereof
US10098694B2 (en) 2013-04-08 2018-10-16 Apama Medical, Inc. Tissue ablation and monitoring thereof
US10349824B2 (en) 2013-04-08 2019-07-16 Apama Medical, Inc. Tissue mapping and visualization systems
EP2997354A4 (en) 2013-05-13 2017-01-18 The General Hospital Corporation Detecting self-interefering fluorescence phase and amplitude
JP2016523147A (en) 2013-06-21 2016-08-08 ボストン サイエンティフィック サイムド，インコーポレイテッドＢｏｓｔｏｎ Ｓｃｉｅｎｔｉｆｉｃ Ｓｃｉｍｅｄ，Ｉｎｃ． Renal denervation balloon catheter with a riding-type electrode support
US10022182B2 (en) 2013-06-21 2018-07-17 Boston Scientific Scimed, Inc. Medical devices for renal nerve ablation having rotatable shafts
US9707036B2 (en) 2013-06-25 2017-07-18 Boston Scientific Scimed, Inc. Devices and methods for nerve modulation using localized indifferent electrodes
WO2015002787A1 (en) 2013-07-01 2015-01-08 Boston Scientific Scimed, Inc. Medical devices for renal nerve ablation
EP3019105B1 (en) 2013-07-11 2017-09-13 Boston Scientific Scimed, Inc. Devices for nerve modulation
US10413357B2 (en) 2013-07-11 2019-09-17 Boston Scientific Scimed, Inc. Medical device with stretchable electrode assemblies
EP4349242A2 (en) 2013-07-19 2024-04-10 The General Hospital Corporation Imaging apparatus and method which utilizes multidirectional field of view endoscopy
CN105682594B (en) 2013-07-19 2018-06-22 波士顿科学国际有限公司 Helical bipolar electrodes renal denervation dominates air bag
WO2015010133A1 (en) 2013-07-19 2015-01-22 The General Hospital Corporation Determining eye motion by imaging retina. with feedback
EP3024406B1 (en) 2013-07-22 2019-06-19 Boston Scientific Scimed, Inc. Medical devices for renal nerve ablation
EP3024405A1 (en) 2013-07-22 2016-06-01 Boston Scientific Scimed, Inc. Renal nerve ablation catheter having twist balloon
US9668652B2 (en) 2013-07-26 2017-06-06 The General Hospital Corporation System, apparatus and method for utilizing optical dispersion for fourier-domain optical coherence tomography
DE102013012692A1 (en) * 2013-07-31 2015-02-05 Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. Method and device for detecting foreign bodies or other scattering centers in optically transparent containers
WO2015027096A1 (en) 2013-08-22 2015-02-26 Boston Scientific Scimed, Inc. Flexible circuit having improved adhesion to a renal nerve modulation balloon
US9895194B2 (en) 2013-09-04 2018-02-20 Boston Scientific Scimed, Inc. Radio frequency (RF) balloon catheter having flushing and cooling capability
EP3043733A1 (en) 2013-09-13 2016-07-20 Boston Scientific Scimed, Inc. Ablation balloon with vapor deposited cover layer
US11246654B2 (en) 2013-10-14 2022-02-15 Boston Scientific Scimed, Inc. Flexible renal nerve ablation devices and related methods of use and manufacture
US9687166B2 (en) 2013-10-14 2017-06-27 Boston Scientific Scimed, Inc. High resolution cardiac mapping electrode array catheter
US9962223B2 (en) 2013-10-15 2018-05-08 Boston Scientific Scimed, Inc. Medical device balloon
US9770606B2 (en) 2013-10-15 2017-09-26 Boston Scientific Scimed, Inc. Ultrasound ablation catheter with cooling infusion and centering basket
EP3057521B1 (en) 2013-10-18 2020-03-25 Boston Scientific Scimed, Inc. Balloon catheters with flexible conducting wires
US10271898B2 (en) 2013-10-25 2019-04-30 Boston Scientific Scimed, Inc. Embedded thermocouple in denervation flex circuit
EP3091922B1 (en) 2014-01-06 2018-10-17 Boston Scientific Scimed, Inc. Tear resistant flex circuit assembly
US9733460B2 (en) 2014-01-08 2017-08-15 The General Hospital Corporation Method and apparatus for microscopic imaging
WO2015116986A2 (en) 2014-01-31 2015-08-06 The General Hospital Corporation System and method for facilitating manual and/or automatic volumetric imaging with real-time tension or force feedback using a tethered imaging device
EP3424453A1 (en) 2014-02-04 2019-01-09 Boston Scientific Scimed, Inc. Alternative placement of thermal sensors on bipolar electrode
US11000679B2 (en) 2014-02-04 2021-05-11 Boston Scientific Scimed, Inc. Balloon protection and rewrapping devices and related methods of use
ES2811323T3 (en) 2014-02-06 2021-03-11 Bard Inc C R Systems for the guidance and placement of an intravascular device
WO2015153982A1 (en) 2014-04-04 2015-10-08 The General Hospital Corporation Apparatus and method for controlling propagation and/or transmission of electromagnetic radiation in flexible waveguide(s)
EP3155361A2 (en) * 2014-06-10 2017-04-19 Carl Zeiss Meditec, Inc. Improved frequency-domain interferometric based imaging systems and methods
WO2016015052A1 (en) 2014-07-25 2016-01-28 The General Hospital Corporation Apparatus, devices and methods for in vivo imaging and diagnosis
US10973584B2 (en) 2015-01-19 2021-04-13 Bard Access Systems, Inc. Device and method for vascular access
US10420537B2 (en) 2015-03-27 2019-09-24 Shifamed Holdings, Llc Steerable medical devices, systems, and methods of use
CA2982823A1 (en) 2015-04-24 2016-10-27 Shifamed Holdings, Llc Steerable medical devices, systems, and methods of use
WO2016210325A1 (en) 2015-06-26 2016-12-29 C.R. Bard, Inc. Connector interface for ecg-based catheter positioning system
US10933221B2 (en) 2015-11-09 2021-03-02 Kalila Medical, Inc. Steering assemblies for medical devices, and methods of use
EP4302713A3 (en) 2015-11-16 2024-03-13 Boston Scientific Scimed, Inc. Energy delivery devices
CN108431626B (en) * 2015-12-20 2022-06-17 苹果公司 Light detection and ranging sensor
JP6703839B2 (en) * 2016-01-14 2020-06-03 株式会社トプコン Ophthalmic measuring device
US11000207B2 (en) 2016-01-29 2021-05-11 C. R. Bard, Inc. Multiple coil system for tracking a medical device
US10982947B2 (en) * 2017-06-12 2021-04-20 Sightline Innovation Inc. System and method of surface inspection of an object using mulitplexed optical coherence tomography
WO2019014767A1 (en) 2017-07-18 2019-01-24 Perimeter Medical Imaging, Inc. Sample container for stabilizing and aligning excised biological tissue samples for ex vivo analysis
CN108036726B (en) * 2017-12-05 2020-12-22 中国科学院合肥物质科学研究院 Device for measuring nanowire displacement by using polarization maintaining optical fiber and double micro lenses
JP6880513B2 (en) * 2018-03-13 2021-06-02 オムロン株式会社 Optical measuring device and optical measuring method
US10992079B2 (en) 2018-10-16 2021-04-27 Bard Access Systems, Inc. Safety-equipped connection systems and methods thereof for establishing electrical connections
EP3999897A1 (en) 2019-07-17 2022-05-25 Scoptonic SP. Z.O.O. High sensitivity optical devices using pupil splittig means

Family Cites Families (133)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US347528A (en) 1886-08-17 speee
US2339754A (en) * 1941-03-04 1944-01-25 Westinghouse Electric & Mfg Co Supervisory apparatus
US4295738A (en) * 1979-08-30 1981-10-20 United Technologies Corporation Fiber optic strain sensor
US4300816A (en) 1979-08-30 1981-11-17 United Technologies Corporation Wide band multicore optical fiber
US5065331A (en) 1981-05-18 1991-11-12 Vachon Reginald I Apparatus and method for determining the stress and strain in pipes, pressure vessels, structural members and other deformable bodies
US4601036A (en) * 1982-09-30 1986-07-15 Honeywell Inc. Rapidly tunable laser
CH663466A5 (en) * 1983-09-12 1987-12-15 Battelle Memorial Institute METHOD AND DEVICE FOR DETERMINING THE POSITION OF AN OBJECT IN RELATION TO A REFERENCE.
US4631498A (en) 1985-04-26 1986-12-23 Hewlett-Packard Company CW Laser wavemeter/frequency locking technique
US5040889A (en) 1986-05-30 1991-08-20 Pacific Scientific Company Spectrometer with combined visible and ultraviolet sample illumination
US4770492A (en) * 1986-10-28 1988-09-13 Spectran Corporation Pressure or strain sensitive optical fiber
JPH0760273B2 (en) * 1987-10-26 1995-06-28 キヤノン株式会社 Magnetic developer
FR2626367B1 (en) * 1988-01-25 1990-05-11 Thomson Csf MULTI-POINT FIBER OPTIC TEMPERATURE SENSOR
FR2626383B1 (en) * 1988-01-27 1991-10-25 Commissariat Energie Atomique EXTENDED FIELD SCAN AND DEPTH CONFOCAL OPTICAL MICROSCOPY AND DEVICES FOR CARRYING OUT THE METHOD
US4925302A (en) * 1988-04-13 1990-05-15 Hewlett-Packard Company Frequency locking device
EP1245987B1 (en) * 1988-07-13 2008-01-23 Optiscan Pty Ltd Scanning confocal microscope
GB8817672D0 (en) 1988-07-25 1988-09-01 Sira Ltd Optical apparatus
US4868834A (en) * 1988-09-14 1989-09-19 The United States Of America As Represented By The Secretary Of The Army System for rapidly tuning a low pressure pulsed laser
DE3833602A1 (en) * 1988-10-03 1990-02-15 Krupp Gmbh SPECTROMETER FOR SIMULTANEOUS INTENSITY MEASUREMENT IN DIFFERENT SPECTRAL AREAS
ATE133545T1 (en) * 1988-12-21 1996-02-15 Massachusetts Inst Technology METHOD FOR LASER-INDUCED FLUORESCENCE OF TISSUE
US5046501A (en) * 1989-01-18 1991-09-10 Wayne State University Atherosclerotic identification
US5317389A (en) * 1989-06-12 1994-05-31 California Institute Of Technology Method and apparatus for white-light dispersed-fringe interferometric measurement of corneal topography
US5039193A (en) * 1990-04-03 1991-08-13 Focal Technologies Incorporated Fibre optic single mode rotary joint
US5262644A (en) 1990-06-29 1993-11-16 Southwest Research Institute Remote spectroscopy for raman and brillouin scattering
US5197470A (en) * 1990-07-16 1993-03-30 Eastman Kodak Company Near infrared diagnostic method and instrument
GB9015793D0 (en) 1990-07-18 1990-09-05 Medical Res Council Confocal scanning optical microscope
US5127730A (en) 1990-08-10 1992-07-07 Regents Of The University Of Minnesota Multi-color laser scanning confocal imaging system
US5305759A (en) * 1990-09-26 1994-04-26 Olympus Optical Co., Ltd. Examined body interior information observing apparatus by using photo-pulses controlling gains for depths
US5202745A (en) * 1990-11-07 1993-04-13 Hewlett-Packard Company Polarization independent optical coherence-domain reflectometry
JP3035336B2 (en) 1990-11-27 2000-04-24 興和株式会社 Blood flow measurement device
US5293872A (en) * 1991-04-03 1994-03-15 Alfano Robert R Method for distinguishing between calcified atherosclerotic tissue and fibrous atherosclerotic tissue or normal cardiovascular tissue using Raman spectroscopy
US5956355A (en) * 1991-04-29 1999-09-21 Massachusetts Institute Of Technology Method and apparatus for performing optical measurements using a rapidly frequency-tuned laser
JP3479069B2 (en) * 1991-04-29 2003-12-15 マサチューセッツ・インステチュート・オブ・テクノロジー Method and apparatus for optical imaging and measurement
US6564087B1 (en) * 1991-04-29 2003-05-13 Massachusetts Institute Of Technology Fiber optic needle probes for optical coherence tomography imaging
US5748598A (en) * 1995-12-22 1998-05-05 Massachusetts Institute Of Technology Apparatus and methods for reading multilayer storage media using short coherence length sources
US6111645A (en) * 1991-04-29 2000-08-29 Massachusetts Institute Of Technology Grating based phase control optical delay line
US6134003A (en) * 1991-04-29 2000-10-17 Massachusetts Institute Of Technology Method and apparatus for performing optical measurements using a fiber optic imaging guidewire, catheter or endoscope
US5465147A (en) 1991-04-29 1995-11-07 Massachusetts Institute Of Technology Method and apparatus for acquiring images using a ccd detector array and no transverse scanner
US5441053A (en) * 1991-05-03 1995-08-15 University Of Kentucky Research Foundation Apparatus and method for multiple wavelength of tissue
DE4128744C1 (en) 1991-08-29 1993-04-22 Siemens Ag, 8000 Muenchen, De
US5353790A (en) * 1992-01-17 1994-10-11 Board Of Regents, The University Of Texas System Method and apparatus for optical measurement of bilirubin in tissue
US5248876A (en) 1992-04-21 1993-09-28 International Business Machines Corporation Tandem linear scanning confocal imaging system with focal volumes at different heights
US5486701A (en) * 1992-06-16 1996-01-23 Prometrix Corporation Method and apparatus for measuring reflectance in two wavelength bands to enable determination of thin film thickness
US5698397A (en) 1995-06-07 1997-12-16 Sri International Up-converting reporters for biological and other assays using laser excitation techniques
US5772597A (en) * 1992-09-14 1998-06-30 Sextant Medical Corporation Surgical tool end effector
AU5672194A (en) * 1992-11-18 1994-06-22 Spectrascience, Inc. Apparatus for diagnostic imaging
US5383467A (en) * 1992-11-18 1995-01-24 Spectrascience, Inc. Guidewire catheter and apparatus for diagnostic imaging
US5987346A (en) 1993-02-26 1999-11-16 Benaron; David A. Device and method for classification of tissue
DE4310209C2 (en) * 1993-03-29 1996-05-30 Bruker Medizintech Optical stationary imaging in strongly scattering media
DE4314189C1 (en) 1993-04-30 1994-11-03 Bodenseewerk Geraetetech Device for the examination of optical fibres made of glass by means of heterodyne Brillouin spectroscopy
EP0627643B1 (en) 1993-06-03 1999-05-06 Hamamatsu Photonics K.K. Laser scanning optical system using axicon
US5803082A (en) * 1993-11-09 1998-09-08 Staplevision Inc. Omnispectramammography
US5983125A (en) 1993-12-13 1999-11-09 The Research Foundation Of City College Of New York Method and apparatus for in vivo examination of subcutaneous tissues inside an organ of a body using optical spectroscopy
JP3261244B2 (en) * 1993-12-17 2002-02-25 ブラザー工業株式会社 Scanning optical device
US5450203A (en) 1993-12-22 1995-09-12 Electroglas, Inc. Method and apparatus for determining an objects position, topography and for imaging
US5590660A (en) * 1994-03-28 1997-01-07 Xillix Technologies Corp. Apparatus and method for imaging diseased tissue using integrated autofluorescence
DE4411017C2 (en) * 1994-03-30 1995-06-08 Alexander Dr Knuettel Optical stationary spectroscopic imaging in strongly scattering objects through special light focusing and signal detection of light of different wavelengths
TW275570B (en) * 1994-05-05 1996-05-11 Boehringer Mannheim Gmbh
US5459325A (en) 1994-07-19 1995-10-17 Molecular Dynamics, Inc. High-speed fluorescence scanner
US6159445A (en) 1994-07-20 2000-12-12 Nycomed Imaging As Light imaging contrast agents
DE69533903T2 (en) 1994-08-18 2005-12-08 Carl Zeiss Meditec Ag Surgical apparatus controlled by optical coherence tomography
US5491524A (en) 1994-10-05 1996-02-13 Carl Zeiss, Inc. Optical coherence tomography corneal mapping apparatus
US5817144A (en) * 1994-10-25 1998-10-06 Latis, Inc. Method for contemporaneous application OF laser energy and localized pharmacologic therapy
US6033721A (en) * 1994-10-26 2000-03-07 Revise, Inc. Image-based three-axis positioner for laser direct write microchemical reaction
US5600486A (en) 1995-01-30 1997-02-04 Lockheed Missiles And Space Company, Inc. Color separation microlens
US5526338A (en) 1995-03-10 1996-06-11 Yeda Research & Development Co. Ltd. Method and apparatus for storage and retrieval with multilayer optical disks
US5697373A (en) 1995-03-14 1997-12-16 Board Of Regents, The University Of Texas System Optical method and apparatus for the diagnosis of cervical precancers using raman and fluorescence spectroscopies
US5735276A (en) 1995-03-21 1998-04-07 Lemelson; Jerome Method and apparatus for scanning and evaluating matter
US5785651A (en) 1995-06-07 1998-07-28 Keravision, Inc. Distance measuring confocal microscope
WO1997001167A1 (en) 1995-06-21 1997-01-09 Massachusetts Institute Of Technology Apparatus and method for accessing data on multilayered optical media
ATA107495A (en) 1995-06-23 1996-06-15 Fercher Adolf Friedrich Dr COHERENCE BIOMETRY AND TOMOGRAPHY WITH DYNAMIC COHERENT FOCUS
MX9801351A (en) * 1995-08-24 1998-07-31 Purdue Research Foundation Fluorescence lifetime-based imaging and spectroscopy in tissues and other random media.
US6615071B1 (en) * 1995-09-20 2003-09-02 Board Of Regents, The University Of Texas System Method and apparatus for detecting vulnerable atherosclerotic plaque
US5719399A (en) * 1995-12-18 1998-02-17 The Research Foundation Of City College Of New York Imaging and characterization of tissue based upon the preservation of polarized light transmitted therethrough
US5840023A (en) 1996-01-31 1998-11-24 Oraevsky; Alexander A. Optoacoustic imaging for medical diagnosis
US5843000A (en) 1996-05-07 1998-12-01 The General Hospital Corporation Optical biopsy forceps and method of diagnosing tissue
ATA84696A (en) * 1996-05-14 1998-03-15 Adolf Friedrich Dr Fercher METHOD AND ARRANGEMENTS FOR INCREASING CONTRAST IN OPTICAL COHERENCE TOMOGRAPHY
US5795295A (en) * 1996-06-25 1998-08-18 Carl Zeiss, Inc. OCT-assisted surgical microscope with multi-coordinate manipulator
US5842995A (en) 1996-06-28 1998-12-01 Board Of Regents, The Univerisity Of Texas System Spectroscopic probe for in vivo measurement of raman signals
EP0928433A1 (en) * 1996-09-27 1999-07-14 Vincent Lauer Microscope generating a three-dimensional representation of an object
DE19640495C2 (en) * 1996-10-01 1999-12-16 Leica Microsystems Device for confocal surface measurement
US6044288A (en) * 1996-11-08 2000-03-28 Imaging Diagnostics Systems, Inc. Apparatus and method for determining the perimeter of the surface of an object being scanned
US5872879A (en) * 1996-11-25 1999-02-16 Boston Scientific Corporation Rotatable connecting optical fibers
US5871449A (en) * 1996-12-27 1999-02-16 Brown; David Lloyd Device and method for locating inflamed plaque in an artery
US5991697A (en) 1996-12-31 1999-11-23 The Regents Of The University Of California Method and apparatus for optical Doppler tomographic imaging of fluid flow velocity in highly scattering media
US5760901A (en) * 1997-01-28 1998-06-02 Zetetic Institute Method and apparatus for confocal interference microscopy with background amplitude reduction and compensation
US6010449A (en) * 1997-02-28 2000-01-04 Lumend, Inc. Intravascular catheter system for treating a vascular occlusion
US5968064A (en) * 1997-02-28 1999-10-19 Lumend, Inc. Catheter system for treating a vascular occlusion
US6120516A (en) * 1997-02-28 2000-09-19 Lumend, Inc. Method for treating vascular occlusion
US6201989B1 (en) * 1997-03-13 2001-03-13 Biomax Technologies Inc. Methods and apparatus for detecting the rejection of transplanted tissue
US5994690A (en) 1997-03-17 1999-11-30 Kulkarni; Manish D. Image enhancement in optical coherence tomography using deconvolution
US6117128A (en) * 1997-04-30 2000-09-12 Kenton W. Gregory Energy delivery catheter and method for the use thereof
US5887009A (en) 1997-05-22 1999-03-23 Optical Biopsy Technologies, Inc. Confocal optical scanning system employing a fiber laser
US6002480A (en) 1997-06-02 1999-12-14 Izatt; Joseph A. Depth-resolved spectroscopic optical coherence tomography
DE69840791D1 (en) 1997-06-02 2009-06-10 Joseph A Izatt DOPPLER ILLUSTRATION OF A FLOW THROUGH OPTICAL COHERENCE TOMOGRAPHY
US6208415B1 (en) * 1997-06-12 2001-03-27 The Regents Of The University Of California Birefringence imaging in biological tissue using polarization sensitive optical coherent tomography
US5920390A (en) * 1997-06-26 1999-07-06 University Of North Carolina Fiberoptic interferometer and associated method for analyzing tissue
US5921926A (en) 1997-07-28 1999-07-13 University Of Central Florida Three dimensional optical imaging colposcopy
US5892583A (en) * 1997-08-21 1999-04-06 Li; Ming-Chiang High speed inspection of a sample using superbroad radiation coherent interferometer
US6069698A (en) * 1997-08-28 2000-05-30 Olympus Optical Co., Ltd. Optical imaging apparatus which radiates a low coherence light beam onto a test object, receives optical information from light scattered by the object, and constructs therefrom a cross-sectional image of the object
US5920373A (en) * 1997-09-24 1999-07-06 Heidelberg Engineering Optische Messysteme Gmbh Method and apparatus for determining optical characteristics of a cornea
US5951482A (en) * 1997-10-03 1999-09-14 Intraluminal Therapeutics, Inc. Assemblies and methods for advancing a guide wire through body tissue
US6193676B1 (en) * 1997-10-03 2001-02-27 Intraluminal Therapeutics, Inc. Guide wire assembly
US6091984A (en) * 1997-10-10 2000-07-18 Massachusetts Institute Of Technology Measuring tissue morphology
US6134010A (en) 1997-11-07 2000-10-17 Lucid, Inc. Imaging system using polarization effects to enhance image quality
EP1057063A4 (en) * 1998-02-26 2004-10-06 Gen Hospital Corp Confocal microscopy with multi-spectral encoding
US6831781B2 (en) * 1998-02-26 2004-12-14 The General Hospital Corporation Confocal microscopy with multi-spectral encoding and system and apparatus for spectroscopically encoded confocal microscopy
US6048742A (en) * 1998-02-26 2000-04-11 The United States Of America As Represented By The Secretary Of The Air Force Process for measuring the thickness and composition of thin semiconductor films deposited on semiconductor wafers
US6066102A (en) * 1998-03-09 2000-05-23 Spectrascience, Inc. Optical biopsy forceps system and method of diagnosing tissue
US6151522A (en) 1998-03-16 2000-11-21 The Research Foundation Of Cuny Method and system for examining biological materials using low power CW excitation raman spectroscopy
DE19814057B4 (en) * 1998-03-30 2009-01-02 Carl Zeiss Meditec Ag Arrangement for optical coherence tomography and coherence topography
US6384915B1 (en) * 1998-03-30 2002-05-07 The Regents Of The University Of California Catheter guided by optical coherence domain reflectometry
US6175669B1 (en) * 1998-03-30 2001-01-16 The Regents Of The Universtiy Of California Optical coherence domain reflectometry guidewire
US6053613A (en) * 1998-05-15 2000-04-25 Carl Zeiss, Inc. Optical coherence tomography with new interferometer
US6549801B1 (en) * 1998-06-11 2003-04-15 The Regents Of The University Of California Phase-resolved optical coherence tomography and optical doppler tomography for imaging fluid flow in tissue with fast scanning speed and high velocity sensitivity
US6379345B1 (en) * 1998-07-15 2002-04-30 Corazon Technologies, Inc. Methods and devices for reducing the mineral content of vascular calcified lesions
US6191862B1 (en) * 1999-01-20 2001-02-20 Lightlab Imaging, Llc Methods and apparatus for high speed longitudinal scanning in imaging systems
US6272376B1 (en) * 1999-01-22 2001-08-07 Cedars-Sinai Medical Center Time-resolved, laser-induced fluorescence for the characterization of organic material
US6445944B1 (en) * 1999-02-01 2002-09-03 Scimed Life Systems Medical scanning system and related method of scanning
US6185271B1 (en) * 1999-02-16 2001-02-06 Richard Estyn Kinsinger Helical computed tomography with feedback scan control
US6353693B1 (en) * 1999-05-31 2002-03-05 Sanyo Electric Co., Ltd. Optical communication device and slip ring unit for an electronic component-mounting apparatus
US6208887B1 (en) * 1999-06-24 2001-03-27 Richard H. Clarke Catheter-delivered low resolution Raman scattering analyzing system for detecting lesions
US7426409B2 (en) * 1999-06-25 2008-09-16 Board Of Regents, The University Of Texas System Method and apparatus for detecting vulnerable atherosclerotic plaque
US6687010B1 (en) * 1999-09-09 2004-02-03 Olympus Corporation Rapid depth scanning optical imaging device
US6393312B1 (en) * 1999-10-13 2002-05-21 C. R. Bard, Inc. Connector for coupling an optical fiber tissue localization device to a light source
EP1240476A1 (en) * 1999-12-09 2002-09-18 Oti Ophthalmic Technologies Inc. Optical mapping apparatus with adjustable depth resolution
US6665075B2 (en) * 2000-11-14 2003-12-16 Wm. Marshurice University Interferometric imaging system and method
US6558324B1 (en) * 2000-11-22 2003-05-06 Siemens Medical Solutions, Inc., Usa System and method for strain image display
US6687007B1 (en) * 2000-12-14 2004-02-03 Kestrel Corporation Common path interferometer for spectral image generation
US6552796B2 (en) * 2001-04-06 2003-04-22 Lightlab Imaging, Llc Apparatus and method for selective data collection and signal to noise ratio enhancement using optical coherence tomography
DE10118760A1 (en) * 2001-04-17 2002-10-31 Med Laserzentrum Luebeck Gmbh Procedure for determining the runtime distribution and arrangement
US20040166593A1 (en) * 2001-06-22 2004-08-26 Nolte David D. Adaptive interferometric multi-analyte high-speed biosensor
US6685885B2 (en) * 2001-06-22 2004-02-03 Purdue Research Foundation Bio-optical compact dist system
US7006231B2 (en) * 2001-10-18 2006-02-28 Scimed Life Systems, Inc. Diffraction grating based interferometric systems and methods

Also Published As

Publication number Publication date
EP2290319B1 (en) 2015-08-26
CN101598685B (en) 2013-11-06
CA2473465A1 (en) 2003-07-24
CN1639539A (en) 2005-07-13
WO2003060423A3 (en) 2003-12-11
EP2290319A1 (en) 2011-03-02
AU2009202383B2 (en) 2012-09-13
EP1468245B1 (en) 2011-03-30
AU2003207507A1 (en) 2003-07-30
EP2327954A1 (en) 2011-06-01
JP2005530128A (en) 2005-10-06
EP2290318B1 (en) 2015-08-26
DE60336534D1 (en) 2011-05-12
AU2009202383A1 (en) 2009-07-09
WO2003060423A8 (en) 2005-05-19
US20050018200A1 (en) 2005-01-27
US7310150B2 (en) 2007-12-18
WO2003060423A2 (en) 2003-07-24
EP2290318A1 (en) 2011-03-02
ATE503982T1 (en) 2011-04-15
CN101598685A (en) 2009-12-09
EP1468245A2 (en) 2004-10-20
AU2003207507A2 (en) 2003-07-30

Similar Documents

Publication Publication Date Title
CA2473465C (en) Apparatus for low coherence ranging
US8676013B2 (en) Imaging system using and related techniques
US8773757B2 (en) Slit-scan multi-wavelength confocal lens module and slit-scan microscopic system and method using the same
JP6671296B2 (en) Simple optical system, more specifically an optical scanning microscope with various pupil positions
JP2015505039A (en) Non-contact surface shape evaluation using modulated light
Ruprecht et al. Confocal micro-optical distance sensor: principle and design
AU2010246485B2 (en) Triangulation camera device and triangulation imaging method
Wang et al. Measurement of a fiber-end surface profile by use of phase-shifting laser interferometry
JP2002296018A (en) Three-dimensional shape measuring instrument
JP2020198999A (en) Optical interference tomographic imaging apparatus
Sato et al. Signal Processing and Artificial Intelligence for Dual-Detection Confocal Probes
WO2019065271A1 (en) Confocal microscope and image creation system

Legal Events

Date Code Title Description
EEER Examination request
MKLA Lapsed

Effective date: 20160111