CA2468677A1 - Stent designed for the delivery of therapeautic substance or other agents - Google Patents

Stent designed for the delivery of therapeautic substance or other agents Download PDF

Info

Publication number
CA2468677A1
CA2468677A1 CA002468677A CA2468677A CA2468677A1 CA 2468677 A1 CA2468677 A1 CA 2468677A1 CA 002468677 A CA002468677 A CA 002468677A CA 2468677 A CA2468677 A CA 2468677A CA 2468677 A1 CA2468677 A1 CA 2468677A1
Authority
CA
Canada
Prior art keywords
stent
turns
strut
shaped recess
struts
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA002468677A
Other languages
French (fr)
Other versions
CA2468677C (en
Inventor
Greg P. Welsh
Lex Jansen
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Boston Scientific Scimed Inc
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2468677A1 publication Critical patent/CA2468677A1/en
Application granted granted Critical
Publication of CA2468677C publication Critical patent/CA2468677C/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/82—Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/86—Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure
    • A61F2/90—Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure characterised by a net-like or mesh-like structure
    • A61F2/91—Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure characterised by a net-like or mesh-like structure made from perforated sheet material or tubes, e.g. perforated by laser cuts or etched holes
    • A61F2/915—Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure characterised by a net-like or mesh-like structure made from perforated sheet material or tubes, e.g. perforated by laser cuts or etched holes with bands having a meander structure, adjacent bands being connected to each other
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
    • A61L31/14—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
    • A61L31/14—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L31/16—Biologically active materials, e.g. therapeutic substances
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/82—Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/86—Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure
    • A61F2/90—Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure characterised by a net-like or mesh-like structure
    • A61F2/91—Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure characterised by a net-like or mesh-like structure made from perforated sheet material or tubes, e.g. perforated by laser cuts or etched holes
    • A61F2/915—Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure characterised by a net-like or mesh-like structure made from perforated sheet material or tubes, e.g. perforated by laser cuts or etched holes with bands having a meander structure, adjacent bands being connected to each other
    • A61F2002/91525—Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure characterised by a net-like or mesh-like structure made from perforated sheet material or tubes, e.g. perforated by laser cuts or etched holes with bands having a meander structure, adjacent bands being connected to each other within the whole structure different bands showing different meander characteristics, e.g. frequency or amplitude
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/82—Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/86—Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure
    • A61F2/90—Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure characterised by a net-like or mesh-like structure
    • A61F2/91—Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure characterised by a net-like or mesh-like structure made from perforated sheet material or tubes, e.g. perforated by laser cuts or etched holes
    • A61F2/915—Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure characterised by a net-like or mesh-like structure made from perforated sheet material or tubes, e.g. perforated by laser cuts or etched holes with bands having a meander structure, adjacent bands being connected to each other
    • A61F2002/91533—Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure characterised by a net-like or mesh-like structure made from perforated sheet material or tubes, e.g. perforated by laser cuts or etched holes with bands having a meander structure, adjacent bands being connected to each other characterised by the phase between adjacent bands
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/82—Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/86—Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure
    • A61F2/90—Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure characterised by a net-like or mesh-like structure
    • A61F2/91—Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure characterised by a net-like or mesh-like structure made from perforated sheet material or tubes, e.g. perforated by laser cuts or etched holes
    • A61F2/915—Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure characterised by a net-like or mesh-like structure made from perforated sheet material or tubes, e.g. perforated by laser cuts or etched holes with bands having a meander structure, adjacent bands being connected to each other
    • A61F2002/9155—Adjacent bands being connected to each other
    • A61F2002/91558—Adjacent bands being connected to each other connected peak to peak
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/82—Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/86—Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure
    • A61F2/90—Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure characterised by a net-like or mesh-like structure
    • A61F2/91—Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure characterised by a net-like or mesh-like structure made from perforated sheet material or tubes, e.g. perforated by laser cuts or etched holes
    • A61F2/915—Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure characterised by a net-like or mesh-like structure made from perforated sheet material or tubes, e.g. perforated by laser cuts or etched holes with bands having a meander structure, adjacent bands being connected to each other
    • A61F2002/9155—Adjacent bands being connected to each other
    • A61F2002/91566—Adjacent bands being connected to each other connected trough to trough
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/82—Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/86—Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure
    • A61F2/90—Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure characterised by a net-like or mesh-like structure
    • A61F2/91—Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure characterised by a net-like or mesh-like structure made from perforated sheet material or tubes, e.g. perforated by laser cuts or etched holes
    • A61F2/915—Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure characterised by a net-like or mesh-like structure made from perforated sheet material or tubes, e.g. perforated by laser cuts or etched holes with bands having a meander structure, adjacent bands being connected to each other
    • A61F2002/9155—Adjacent bands being connected to each other
    • A61F2002/91575—Adjacent bands being connected to each other connected peak to trough
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2230/00—Geometry of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
    • A61F2230/0002—Two-dimensional shapes, e.g. cross-sections
    • A61F2230/0004—Rounded shapes, e.g. with rounded corners
    • A61F2230/0013—Horseshoe-shaped, e.g. crescent-shaped, C-shaped, U-shaped
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2230/00—Geometry of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
    • A61F2230/0002—Two-dimensional shapes, e.g. cross-sections
    • A61F2230/0028—Shapes in the form of latin or greek characters
    • A61F2230/0054—V-shaped
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2250/00—Special features of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
    • A61F2250/0014—Special features of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof having different values of a given property or geometrical feature, e.g. mechanical property or material property, at different locations within the same prosthesis
    • A61F2250/0018—Special features of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof having different values of a given property or geometrical feature, e.g. mechanical property or material property, at different locations within the same prosthesis differing in elasticity, stiffness or compressibility
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2250/00—Special features of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
    • A61F2250/0014—Special features of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof having different values of a given property or geometrical feature, e.g. mechanical property or material property, at different locations within the same prosthesis
    • A61F2250/0035—Special features of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof having different values of a given property or geometrical feature, e.g. mechanical property or material property, at different locations within the same prosthesis differing in release or diffusion time
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2250/00—Special features of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
    • A61F2250/0014—Special features of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof having different values of a given property or geometrical feature, e.g. mechanical property or material property, at different locations within the same prosthesis
    • A61F2250/0036—Special features of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof having different values of a given property or geometrical feature, e.g. mechanical property or material property, at different locations within the same prosthesis differing in thickness
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2250/00—Special features of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
    • A61F2250/0058—Additional features; Implant or prostheses properties not otherwise provided for
    • A61F2250/0067—Means for introducing or releasing pharmaceutical products into the body
    • A61F2250/0068—Means for introducing or releasing pharmaceutical products into the body the pharmaceutical product being in a reservoir

Abstract

A stent comprising a serpentine portion extending about the circumference of the stent, the serpentine portion having a first end and a second end, the serpentine portion having a plurality of turns at the first end and a plurality of turns at the second end and struts extending therebetween, at least one of the turns at the first end, at least one of the turns at the second end, at least one of the struts therebetween, or some combination thereof having a plurality of shaped recesses thereon.

Claims (28)

1. A stent comprising a strut having a first side and a second side, each side having alternating crests and troughs wherein the crests of said first side of said strut align with the troughs of said second side of said strut, said strut having at least one adjacent strut having a first side and a second side, each side having alternating crests and troughs wherein the crests of said first side of said at least one adjacent strut align with said troughs of said second side of said at least one adjacent strut, and said crests of said first side of said strut align with said crests of said second side of said adjacent strut and said troughs of said first side of said strut align with said troughs of said second side of said adjacent strut.
2. The stent of Claim 1 wherein said strut has a wave-like pattern.
3. The stent of Claim 1 wherein said at least one adjacent strut has a wave-like pattern.
4. The stent of Claim 1 having at least one shaped recess located between at least one crest and trough of said strut.
5. The stent of Claim 1 having shaped recesses located between the crests and troughs of said strut and said adjacent strut.
6. The stent of Claim 4 wherein said at least one shaped recess is an elongated ellipsoid.
7. The stent of Claim 4 wherein said at least one shaped recess has a substantially circular shape.
8. The stent of Claim 4 wherein said at least one shaped recess contains a therapeutic agent.
9. The stent of Claim 10 wherein said therapeutic agent is selected from the group consisting of genetic material, growth factors, antineoplastics, antimitotics, anti-inflammatories, antiplatelets, anticoagulants, antifibrins, antithrombins, antiproliferatives, antibiotics, antioxidants, and antiallergenic substances.
10. The stent of Claim 9 wherein said therapeutic agent is selected from the group consisting of genetic material, growth factors, antineoplastics, antimitotics, anti-inflammatories, antiplatelets, anticoagulants, antifibrins, antithrombins, antiproliferatives, antibiotics, antioxidants, and antiallergenic substances.
11. A stent comprising a serpentine portion extending about the circumference of the stent, the serpentiile portion having a first end and a second end, the serpentine portion having a plurality of turns at the first end and a plurality of turns at the second end and struts extending therebetween, at least one of the turns at the first end, at least one of the turns at the second end, at least one of the struts therebetween, or some combination thereof having a plurality of shaped recesses thereon.
12. The stent of Claim 11 wherein said shaped recesses are substantially circular.
13. The stent of Claim 11 wherein a plurality of said struts have a plurality of shapeded recesses thereon and a plurality of turns have a plurality of shaped recesses thereon.
14. The stent of Claim 11 wherein each turn at each end of each serpentine portion has a plurality of shaped recesses thereon.
15. The stent of Claim 11 having a plurality of shaped recesses having substantially circular and elongated ellipsoid shapes.
16. The stent of Claim 11 wherein each of said at least some of said turns at said first end, each of said some of said turns at said second end, and each of said some of said struts have a plurality of shaped recesses thereon.
17. The stent of Claim 16 wherein said shaped recess has a substantially circular shape.
18. The stent of Claim 17 further in combination with elongated ellipsoid shaped recesses.
19. The stent of Claim 11 wherein said shaped recesses contain a therapeutic agent.
20. The stent of Claim 19 wherein said therapeutic agent is selected from the group consisting of genetic material, growth factors, antineoplastics, antimitotics, anti-inflammatories, antiplatelets, anticoagulants, antifibrins, antithrombins, antiproliferatives, antibiotics, antioxidants, and antiallergenic substances.
21. A stent comprising a serpentine portion extending about the circumference of the stmt, the serpentine portion having a first end and a second end, the serpentine portion having a plurality of turns at the first end and a plurality of turns at the second end and struts extending therebetween wherein at least some of said struts have at least one shaped recess thereon, said shaped recess smaller in dimension than said struts while the turns are free of shaped recesses.
22. The stent of Claim 21 wherein at least some of said turns at the first end, at least some of the turns at the second end, or some combination thereof have at least one shaped recess thereon.
23. The stent of Claim 21 wherein said shaped recess is an elongated ellipsoid.
24. The stent of Claim 21 wherein said shaped recess has a substantially circular shape.
25. The stent of Claim 21 wherein said at least some of said struts have more than one shaped recess thereon.
26. The stent of Claim 21 wherein said at least some of said turns at said first end, some of said turns at said second end, or some combination thereof have more than one shaped recess thereon.
27. The stent of Claim 26 wherein said shaped recess has a substantially circular shape.
28. The stent of Claim 27 wherein said shaped recess has a substantially circular shape.

30. The stent of Claim 21 wherein said at least one shaped recess contains a therapeutic agent.

31. The stent of Claim 30 wherein said therapeutic agent is selected from the group consisting of genetic material, growth factors, antineoplastics, antimitotics, anti-inflammatories, antiplatelets, anticoagulants, antifibrins, antithrombins, antiproliferatives, antibiotics, antioxidants, and antiallergenic substances.
CA2468677A 2001-11-30 2002-11-20 Stent designed for the delivery of therapeautic substance or other agents Expired - Fee Related CA2468677C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US09/999,279 US7014654B2 (en) 2001-11-30 2001-11-30 Stent designed for the delivery of therapeutic substance or other agents
US09/999,279 2001-11-30
PCT/US2002/037337 WO2003047463A1 (en) 2001-11-30 2002-11-20 Stent designed for the delivery of therapeautic substance or other agents

Publications (2)

Publication Number Publication Date
CA2468677A1 true CA2468677A1 (en) 2003-06-12
CA2468677C CA2468677C (en) 2010-09-14

Family

ID=25546131

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2468677A Expired - Fee Related CA2468677C (en) 2001-11-30 2002-11-20 Stent designed for the delivery of therapeautic substance or other agents

Country Status (7)

Country Link
US (2) US7014654B2 (en)
EP (3) EP2255758B1 (en)
JP (1) JP4414760B2 (en)
AU (1) AU2002365875A1 (en)
CA (1) CA2468677C (en)
DE (1) DE60237302D1 (en)
WO (1) WO2003047463A1 (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7959664B2 (en) 1996-12-26 2011-06-14 Medinol, Ltd. Flat process of drug coating for stents

Families Citing this family (200)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6783543B2 (en) * 2000-06-05 2004-08-31 Scimed Life Systems, Inc. Intravascular stent with increasing coating retaining capacity
JP4636634B2 (en) 1996-04-26 2011-02-23 ボストン サイエンティフィック サイムド，インコーポレイテッド Intravascular stent
US7070590B1 (en) * 1996-07-02 2006-07-04 Massachusetts Institute Of Technology Microchip drug delivery devices
US7341598B2 (en) 1999-01-13 2008-03-11 Boston Scientific Scimed, Inc. Stent with protruding branch portion for bifurcated vessels
US20030129215A1 (en) * 1998-09-24 2003-07-10 T-Ram, Inc. Medical devices containing rapamycin analogs
US6890546B2 (en) 1998-09-24 2005-05-10 Abbott Laboratories Medical devices containing rapamycin analogs
US20040254635A1 (en) 1998-03-30 2004-12-16 Shanley John F. Expandable medical device for delivery of beneficial agent
US7179289B2 (en) * 1998-03-30 2007-02-20 Conor Medsystems, Inc. Expandable medical device for delivery of beneficial agent
US6241762B1 (en) 1998-03-30 2001-06-05 Conor Medsystems, Inc. Expandable medical device with ductile hinges
US7208010B2 (en) 2000-10-16 2007-04-24 Conor Medsystems, Inc. Expandable medical device for delivery of beneficial agent
US7713297B2 (en) 1998-04-11 2010-05-11 Boston Scientific Scimed, Inc. Drug-releasing stent with ceramic-containing layer
US6290673B1 (en) 1999-05-20 2001-09-18 Conor Medsystems, Inc. Expandable medical device delivery system and method
US20030070676A1 (en) * 1999-08-05 2003-04-17 Cooper Joel D. Conduits having distal cage structure for maintaining collateral channels in tissue and related methods
ES2332869T3 (en) * 1999-11-17 2010-02-15 Boston Scientific Limited MICROFABRICATED DEVICES FOR THE DELIVERY OF MOLECULES IN CARRIER FLUIDS.
EP2111829B1 (en) * 2000-06-05 2011-01-19 Boston Scientific Limited Intravascular stent with increasing coating retaining capacity
WO2002032347A2 (en) 2000-10-16 2002-04-25 Conor Medsystems, Inc. Expandable medical device for delivery of beneficial agent
US6764507B2 (en) 2000-10-16 2004-07-20 Conor Medsystems, Inc. Expandable medical device with improved spatial distribution
ATE289260T1 (en) * 2000-11-13 2005-03-15 Michelin Soc Tech TIRE TREAD AND MOLDING ELEMENT OF A MOLDING TOOL FOR SUCH TREAD
US20040073294A1 (en) 2002-09-20 2004-04-15 Conor Medsystems, Inc. Method and apparatus for loading a beneficial agent into an expandable medical device
AU2002345328A1 (en) 2001-06-27 2003-03-03 Remon Medical Technologies Ltd. Method and device for electrochemical formation of therapeutic species in vivo
US7842083B2 (en) 2001-08-20 2010-11-30 Innovational Holdings, Llc. Expandable medical device with improved spatial distribution
US20060004437A1 (en) * 2001-08-29 2006-01-05 Swaminathan Jayaraman Structurally variable stents
US7708712B2 (en) * 2001-09-04 2010-05-04 Broncus Technologies, Inc. Methods and devices for maintaining patency of surgically created channels in a body organ
US7892273B2 (en) 2001-12-03 2011-02-22 Xtent, Inc. Custom length stent apparatus
US7137993B2 (en) 2001-12-03 2006-11-21 Xtent, Inc. Apparatus and methods for delivery of multiple distributed stents
US7291165B2 (en) * 2002-01-31 2007-11-06 Boston Scientific Scimed, Inc. Medical device for delivering biologically active material
US20110306997A9 (en) * 2002-02-21 2011-12-15 Roschak Edmund J Devices for creating passages and sensing for blood vessels
AU2003221744A1 (en) * 2002-04-19 2003-11-03 Broncus Technologies, Inc. Devices for maintaining surgically created openings
US7083822B2 (en) * 2002-04-26 2006-08-01 Medtronic Vascular, Inc. Overlapping coated stents
US7758636B2 (en) * 2002-09-20 2010-07-20 Innovational Holdings Llc Expandable medical device with openings for delivery of multiple beneficial agents
CA2499594A1 (en) * 2002-09-20 2004-04-01 Conor Medsystems, Inc. Expandable medical device with openings for delivery of multiple beneficial agents
US9498358B2 (en) 2002-09-20 2016-11-22 Innovational Holdings Llc Implantable medical device with openings for delivery of beneficial agents with combination release kinetics
US20040093056A1 (en) 2002-10-26 2004-05-13 Johnson Lianw M. Medical appliance delivery apparatus and method of use
US7875068B2 (en) 2002-11-05 2011-01-25 Merit Medical Systems, Inc. Removable biliary stent
US7959671B2 (en) 2002-11-05 2011-06-14 Merit Medical Systems, Inc. Differential covering and coating methods
US7637942B2 (en) 2002-11-05 2009-12-29 Merit Medical Systems, Inc. Coated stent with geometry determinated functionality and method of making the same
US7169178B1 (en) * 2002-11-12 2007-01-30 Advanced Cardiovascular Systems, Inc. Stent with drug coating
JP5596896B2 (en) 2003-03-28 2014-09-24 イノヴェイショナル・ホールディングズ・エルエルシー Method of forming an implantable medical device having a beneficial agent concentration gradient
US7637934B2 (en) 2003-03-31 2009-12-29 Merit Medical Systems, Inc. Medical appliance optical delivery and deployment apparatus and method
US7604660B2 (en) 2003-05-01 2009-10-20 Merit Medical Systems, Inc. Bifurcated medical appliance delivery apparatus and method
DE10328882B4 (en) * 2003-06-26 2010-06-02 Admedes Schuessler Gmbh Use of a flexible shaft as a hose-like insertion device
US8308682B2 (en) 2003-07-18 2012-11-13 Broncus Medical Inc. Devices for maintaining patency of surgically created channels in tissue
US7326236B2 (en) 2003-12-23 2008-02-05 Xtent, Inc. Devices and methods for controlling and indicating the length of an interventional element
JP2007521928A (en) * 2004-02-13 2007-08-09 コナー　メドシステムズ，　インコーポレイテッド Implantable drug delivery device comprising a wire filament
DE102004012837B4 (en) * 2004-03-16 2006-09-14 Admedes Schuessler Gmbh Stent having a web structure and method of making the same
US8858616B2 (en) * 2004-03-16 2014-10-14 Admedes Schuessler Gmbh Stent having a bridge structure
JP5054524B2 (en) 2004-06-08 2012-10-24 アドバンスド ステント テクノロジーズ， インコーポレイテッド Stent with protruding branch for branch pipe
US20050288766A1 (en) * 2004-06-28 2005-12-29 Xtent, Inc. Devices and methods for controlling expandable prostheses during deployment
US8317859B2 (en) 2004-06-28 2012-11-27 J.W. Medical Systems Ltd. Devices and methods for controlling expandable prostheses during deployment
US8409167B2 (en) 2004-07-19 2013-04-02 Broncus Medical Inc Devices for delivering substances through an extra-anatomic opening created in an airway
JP4876916B2 (en) * 2004-07-30 2012-02-15 株式会社カネカ Stent
JP5207737B2 (en) * 2004-09-15 2013-06-12 イノヴェイショナル・ホールディングズ・エルエルシー Bifurcated stent with collapsible end
US7429268B2 (en) * 2004-12-08 2008-09-30 Innovational Holdings, Llc Expandable medical device with differential hinge performance
US7540995B2 (en) 2005-03-03 2009-06-02 Icon Medical Corp. Process for forming an improved metal alloy stent
US9107899B2 (en) 2005-03-03 2015-08-18 Icon Medical Corporation Metal alloys for medical devices
EP1868529A2 (en) * 2005-03-09 2007-12-26 The University of Tennessee Research Foundation Barrier stent and use thereof
US20070255094A1 (en) * 2005-03-14 2007-11-01 Oepen Randolf V Crack/fatigue resistant endoprosthesis
US20070213810A1 (en) * 2005-03-14 2007-09-13 Richard Newhauser Segmented endoprosthesis
US7837726B2 (en) * 2005-03-14 2010-11-23 Abbott Laboratories Visible endoprosthesis
US20060271170A1 (en) * 2005-05-31 2006-11-30 Gale David C Stent with flexible sections in high strain regions
JP4797473B2 (en) * 2005-07-11 2011-10-19 ニプロ株式会社 Flexible stent with excellent expandability
US20070043423A1 (en) * 2005-08-10 2007-02-22 Med Institute Inc. Intraluminal device with a hollow structure
US20070055352A1 (en) * 2005-09-07 2007-03-08 Wendy Naimark Stent with pockets for containing a therapeutic agent
US20070112421A1 (en) * 2005-11-14 2007-05-17 O'brien Barry Medical device with a grooved surface
US7540881B2 (en) 2005-12-22 2009-06-02 Boston Scientific Scimed, Inc. Bifurcation stent pattern
US20070156230A1 (en) 2006-01-04 2007-07-05 Dugan Stephen R Stents with radiopaque markers
US8840660B2 (en) 2006-01-05 2014-09-23 Boston Scientific Scimed, Inc. Bioerodible endoprostheses and methods of making the same
US20070160672A1 (en) * 2006-01-06 2007-07-12 Vipul Bhupendra Dave Methods of making bioabsorbable drug delivery devices comprised of solvent cast films
US20070158880A1 (en) * 2006-01-06 2007-07-12 Vipul Bhupendra Dave Methods of making bioabsorbable drug delivery devices comprised of solvent cast tubes
US20070162110A1 (en) * 2006-01-06 2007-07-12 Vipul Bhupendra Dave Bioabsorbable drug delivery devices
US8089029B2 (en) 2006-02-01 2012-01-03 Boston Scientific Scimed, Inc. Bioabsorbable metal medical device and method of manufacture
US20100010622A1 (en) * 2006-03-13 2010-01-14 Abbott Laboratories Hybrid segmented endoprosthesis
US8828077B2 (en) 2006-03-15 2014-09-09 Medinol Ltd. Flat process of preparing drug eluting stents
AU2007227000A1 (en) 2006-03-20 2007-09-27 Xtent, Inc. Apparatus and methods for deployment of linked prosthetic segments
US20070224235A1 (en) 2006-03-24 2007-09-27 Barron Tenney Medical devices having nanoporous coatings for controlled therapeutic agent delivery
US8187620B2 (en) 2006-03-27 2012-05-29 Boston Scientific Scimed, Inc. Medical devices comprising a porous metal oxide or metal material and a polymer coating for delivering therapeutic agents
US8048150B2 (en) 2006-04-12 2011-11-01 Boston Scientific Scimed, Inc. Endoprosthesis having a fiber meshwork disposed thereon
US20070254003A1 (en) * 2006-05-01 2007-11-01 Pu Zhou Non-sticky coatings with therapeutic agents for medical devices
EP2023869B1 (en) * 2006-05-12 2019-09-18 Cardinal Health Switzerland 515 GmbH Balloon expandable bioabsorbable drug eluting flexible stent
WO2007134222A2 (en) * 2006-05-12 2007-11-22 Cordis Corporation Baloon expandable bioabsorbable drug eluting stent
US20070275035A1 (en) * 2006-05-24 2007-11-29 Microchips, Inc. Minimally Invasive Medical Implant Devices for Controlled Drug Delivery
US20130325105A1 (en) 2006-05-26 2013-12-05 Abbott Cardiovascular Systems Inc. Stents With Radiopaque Markers
US8815275B2 (en) 2006-06-28 2014-08-26 Boston Scientific Scimed, Inc. Coatings for medical devices comprising a therapeutic agent and a metallic material
WO2008002778A2 (en) 2006-06-29 2008-01-03 Boston Scientific Limited Medical devices with selective coating
WO2008008291A2 (en) * 2006-07-13 2008-01-17 Icon Medical Corp. Stent
US7651523B2 (en) * 2006-07-24 2010-01-26 Cook Incorporated Intraluminal device with flexible regions
EP2054537A2 (en) 2006-08-02 2009-05-06 Boston Scientific Scimed, Inc. Endoprosthesis with three-dimensional disintegration control
US20080065196A1 (en) * 2006-09-12 2008-03-13 Michael Wayne Davis Intra-Columnar Cell Features to Improve Drug Distribution and Scaffolding of a Stent
ATE508708T1 (en) 2006-09-14 2011-05-15 Boston Scient Ltd MEDICAL DEVICES WITH A DRUG-RELEASING COATING
US8057534B2 (en) 2006-09-15 2011-11-15 Boston Scientific Scimed, Inc. Bioerodible endoprostheses and methods of making the same
CA2663220A1 (en) 2006-09-15 2008-03-20 Boston Scientific Limited Medical devices and methods of making the same
EP2210625B8 (en) 2006-09-15 2012-02-29 Boston Scientific Scimed, Inc. Bioerodible endoprosthesis with biostable inorganic layers
CA2663250A1 (en) 2006-09-15 2008-03-20 Boston Scientific Limited Bioerodible endoprostheses and methods of making the same
EP2068962B1 (en) 2006-09-18 2013-01-30 Boston Scientific Limited Endoprostheses
US7951191B2 (en) 2006-10-10 2011-05-31 Boston Scientific Scimed, Inc. Bifurcated stent with entire circumferential petal
US7981150B2 (en) 2006-11-09 2011-07-19 Boston Scientific Scimed, Inc. Endoprosthesis with coatings
US7842082B2 (en) 2006-11-16 2010-11-30 Boston Scientific Scimed, Inc. Bifurcated stent
US20090062910A1 (en) * 2006-11-16 2009-03-05 Shippy Iii James Lee Stent with differential timing of abluminal and luminal release of a therapeutic agent
JP2010512947A (en) * 2006-12-20 2010-04-30 ボストン サイエンティフィック リミテッド Stent with coating for delivering therapeutic agent
JP5355418B2 (en) 2006-12-28 2013-11-27 ボストン サイエンティフィック リミテッド Bioerodible endoprosthesis and method for manufacturing the bioerodible endoprosthesis
EP2107895A1 (en) * 2007-01-29 2009-10-14 Cook Incorporated Medical prosthesis and method of production
US20080199510A1 (en) * 2007-02-20 2008-08-21 Xtent, Inc. Thermo-mechanically controlled implants and methods of use
US8070797B2 (en) 2007-03-01 2011-12-06 Boston Scientific Scimed, Inc. Medical device with a porous surface for delivery of a therapeutic agent
US8431149B2 (en) 2007-03-01 2013-04-30 Boston Scientific Scimed, Inc. Coated medical devices for abluminal drug delivery
US8974514B2 (en) * 2007-03-13 2015-03-10 Abbott Cardiovascular Systems Inc. Intravascular stent with integrated link and ring strut
US8486132B2 (en) 2007-03-22 2013-07-16 J.W. Medical Systems Ltd. Devices and methods for controlling expandable prostheses during deployment
US8067054B2 (en) 2007-04-05 2011-11-29 Boston Scientific Scimed, Inc. Stents with ceramic drug reservoir layer and methods of making and using the same
US7976915B2 (en) 2007-05-23 2011-07-12 Boston Scientific Scimed, Inc. Endoprosthesis with select ceramic morphology
US9402973B2 (en) 2007-07-06 2016-08-02 Vital 5, Llc Constrained fluid delivery device
US20090018633A1 (en) * 2007-07-10 2009-01-15 Boston Scientific Scimed, Inc. Protector for an insertable or implantable medical device
US9216101B2 (en) * 2007-07-10 2015-12-22 Boston Scientific Scime, Inc. Dual taper stent protector
US20090018635A1 (en) * 2007-07-10 2009-01-15 Boston Scientific Scimed, Inc. Stent protector
US8002823B2 (en) 2007-07-11 2011-08-23 Boston Scientific Scimed, Inc. Endoprosthesis coating
US7942926B2 (en) 2007-07-11 2011-05-17 Boston Scientific Scimed, Inc. Endoprosthesis coating
WO2009012353A2 (en) 2007-07-19 2009-01-22 Boston Scientific Limited Endoprosthesis having a non-fouling surface
US7931683B2 (en) 2007-07-27 2011-04-26 Boston Scientific Scimed, Inc. Articles having ceramic coated surfaces
US8815273B2 (en) 2007-07-27 2014-08-26 Boston Scientific Scimed, Inc. Drug eluting medical devices having porous layers
US8221822B2 (en) 2007-07-31 2012-07-17 Boston Scientific Scimed, Inc. Medical device coating by laser cladding
WO2009020520A1 (en) 2007-08-03 2009-02-12 Boston Scientific Scimed, Inc. Coating for medical device having increased surface area
US7959669B2 (en) 2007-09-12 2011-06-14 Boston Scientific Scimed, Inc. Bifurcated stent with open ended side branch support
US8052745B2 (en) 2007-09-13 2011-11-08 Boston Scientific Scimed, Inc. Endoprosthesis
US20090076591A1 (en) * 2007-09-19 2009-03-19 Boston Scientific Scimed, Inc. Stent Design Allowing Extended Release of Drug and/or Enhanced Adhesion of Polymer to OD Surface
CN101411651B (en) * 2007-10-17 2011-03-09 微创医疗器械(上海)有限公司 Internal support for human body lumen with nesting type structure
US8029554B2 (en) 2007-11-02 2011-10-04 Boston Scientific Scimed, Inc. Stent with embedded material
US7938855B2 (en) 2007-11-02 2011-05-10 Boston Scientific Scimed, Inc. Deformable underlayer for stent
US8216632B2 (en) 2007-11-02 2012-07-10 Boston Scientific Scimed, Inc. Endoprosthesis coating
US20090118818A1 (en) * 2007-11-02 2009-05-07 Boston Scientific Scimed, Inc. Endoprosthesis with coating
US7833266B2 (en) 2007-11-28 2010-11-16 Boston Scientific Scimed, Inc. Bifurcated stent with drug wells for specific ostial, carina, and side branch treatment
US8551072B2 (en) 2007-12-12 2013-10-08 Boston Scientific Scimed, Inc. Methods, devices and compositions for controlled drug delivery to injured myocardium
US7722661B2 (en) * 2007-12-19 2010-05-25 Boston Scientific Scimed, Inc. Stent
US7972373B2 (en) * 2007-12-19 2011-07-05 Advanced Technologies And Regenerative Medicine, Llc Balloon expandable bioabsorbable stent with a single stress concentration region interconnecting adjacent struts
US8277501B2 (en) 2007-12-21 2012-10-02 Boston Scientific Scimed, Inc. Bi-stable bifurcated stent petal geometry
EP2254512B1 (en) * 2008-01-24 2016-01-06 Medtronic, Inc. Markers for prosthetic heart valves
JP2011510751A (en) * 2008-02-01 2011-04-07 ボストン サイエンティフィック サイムド，インコーポレイテッド Medical device coated with a drug that separates and releases the drug
US9101503B2 (en) * 2008-03-06 2015-08-11 J.W. Medical Systems Ltd. Apparatus having variable strut length and methods of use
US8252048B2 (en) * 2008-03-19 2012-08-28 Boston Scientific Scimed, Inc. Drug eluting stent and method of making the same
WO2009131911A2 (en) 2008-04-22 2009-10-29 Boston Scientific Scimed, Inc. Medical devices having a coating of inorganic material
WO2009132176A2 (en) 2008-04-24 2009-10-29 Boston Scientific Scimed, Inc. Medical devices having inorganic particle layers
EP2276518A2 (en) * 2008-05-01 2011-01-26 Boston Scientific Scimed, Inc. Drug-loaded medical devices and methods for manufacturing drug-loaded medical devices
US7998192B2 (en) 2008-05-09 2011-08-16 Boston Scientific Scimed, Inc. Endoprostheses
US8932340B2 (en) 2008-05-29 2015-01-13 Boston Scientific Scimed, Inc. Bifurcated stent and delivery system
US8771332B2 (en) * 2008-05-29 2014-07-08 Boston Scientific Scimed, Inc. Multi-layer balloon design for use in combination with catheter assemblies, and methods of making the same
US8236046B2 (en) 2008-06-10 2012-08-07 Boston Scientific Scimed, Inc. Bioerodible endoprosthesis
EP2303350A2 (en) 2008-06-18 2011-04-06 Boston Scientific Scimed, Inc. Endoprosthesis coating
US7951193B2 (en) * 2008-07-23 2011-05-31 Boston Scientific Scimed, Inc. Drug-eluting stent
US7985252B2 (en) 2008-07-30 2011-07-26 Boston Scientific Scimed, Inc. Bioerodible endoprosthesis
WO2010032643A1 (en) * 2008-09-17 2010-03-25 テルモ株式会社 Stent
US8382824B2 (en) 2008-10-03 2013-02-26 Boston Scientific Scimed, Inc. Medical implant having NANO-crystal grains with barrier layers of metal nitrides or fluorides
CN101732114B (en) * 2008-11-04 2014-07-30 上海微创医疗器械（集团）有限公司 Coronary artery stent with medicine carrying grooves
US8231980B2 (en) 2008-12-03 2012-07-31 Boston Scientific Scimed, Inc. Medical implants including iridium oxide
WO2010101901A2 (en) 2009-03-02 2010-09-10 Boston Scientific Scimed, Inc. Self-buffering medical implants
US8071156B2 (en) 2009-03-04 2011-12-06 Boston Scientific Scimed, Inc. Endoprostheses
US8287937B2 (en) 2009-04-24 2012-10-16 Boston Scientific Scimed, Inc. Endoprosthese
US20100292777A1 (en) * 2009-05-13 2010-11-18 Boston Scientific Scimed, Inc. Stent
US9283305B2 (en) 2009-07-09 2016-03-15 Medtronic Vascular, Inc. Hollow tubular drug eluting medical devices
US8460745B2 (en) 2009-09-20 2013-06-11 Medtronic Vascular, Inc. Apparatus and methods for loading a drug eluting medical device
US20110070358A1 (en) 2009-09-20 2011-03-24 Medtronic Vascular, Inc. Method of forming hollow tubular drug eluting medical devices
US8828474B2 (en) 2009-09-20 2014-09-09 Medtronic Vascular, Inc. Apparatus and methods for loading a drug eluting medical device
US8678046B2 (en) 2009-09-20 2014-03-25 Medtronic Vascular, Inc. Apparatus and methods for loading a drug eluting medical device
BR112012007578B1 (en) 2009-09-30 2021-04-20 Terumo Kabushiki Kaisha stent
US8398916B2 (en) 2010-03-04 2013-03-19 Icon Medical Corp. Method for forming a tubular medical device
WO2011119573A1 (en) 2010-03-23 2011-09-29 Boston Scientific Scimed, Inc. Surface treated bioerodible metal endoprostheses
CN102711676A (en) * 2010-03-30 2012-10-03 泰尔茂株式会社 Stent
US9265913B2 (en) 2010-09-22 2016-02-23 Vital 5, Llc Catheter assembly
KR20160103151A (en) * 2010-08-02 2016-08-31 코디스 코포레이션 Flexible helical stent having different helical regions
US8616040B2 (en) 2010-09-17 2013-12-31 Medtronic Vascular, Inc. Method of forming a drug-eluting medical device
US8632846B2 (en) 2010-09-17 2014-01-21 Medtronic Vascular, Inc. Apparatus and methods for loading a drug eluting medical device
US8333801B2 (en) 2010-09-17 2012-12-18 Medtronic Vascular, Inc. Method of Forming a Drug-Eluting Medical Device
US20120245512A1 (en) * 2010-09-22 2012-09-27 Vital 5, Llc Non-linear free state catheter
US9446224B2 (en) 2010-09-22 2016-09-20 Vital 5, L.L.C. Barrier catheter
EP2438891A1 (en) * 2010-10-08 2012-04-11 Biotronik AG Stent having increased visibility in the X-ray image
EP2658484A1 (en) 2010-12-30 2013-11-06 Boston Scientific Scimed, Inc. Multi stage opening stent designs
WO2012119037A1 (en) 2011-03-03 2012-09-07 Boston Scientific Scimed, Inc. Stent with reduced profile
CN103391757B (en) 2011-03-03 2016-01-20 波士顿科学国际有限公司 Low strain dynamic high strength support
EP2692314B1 (en) 2011-03-29 2019-01-09 Terumo Kabushiki Kaisha Stent and stent delivery system
US9345532B2 (en) 2011-05-13 2016-05-24 Broncus Medical Inc. Methods and devices for ablation of tissue
US8709034B2 (en) 2011-05-13 2014-04-29 Broncus Medical Inc. Methods and devices for diagnosing, monitoring, or treating medical conditions through an opening through an airway wall
WO2013078235A1 (en) 2011-11-23 2013-05-30 Broncus Medical Inc Methods and devices for diagnosing, monitoring, or treating medical conditions through an opening through an airway wall
US20140094900A1 (en) 2012-10-01 2014-04-03 Brigham Young University Compliant biocompatible device and method of manufacture
US9913740B2 (en) * 2012-10-25 2018-03-13 W. L. Gore & Associates, Inc. Stent with varying cross-section
WO2014151906A1 (en) * 2013-03-14 2014-09-25 Medtronic Vascular Inc. Method for manufacturing a stent and stent manufactured thereby
DE102013104550B4 (en) * 2013-05-03 2021-07-01 Acandis Gmbh Medical device for insertion into a hollow organ in the body
WO2014186435A2 (en) 2013-05-14 2014-11-20 University Of Georgia Research Foundation, Inc. Compositions and methods for reducing neointima formation
ES2883837T3 (en) 2014-05-02 2021-12-09 The Res Institute At Nationwide Childrens Hospital Compositions and methods for immunomodulation of anti-LYST
CN106535826A (en) 2014-06-24 2017-03-22 怡康医疗股份有限公司 Improved metal alloys for medical devices
US9381103B2 (en) * 2014-10-06 2016-07-05 Abbott Cardiovascular Systems Inc. Stent with elongating struts
US9999527B2 (en) 2015-02-11 2018-06-19 Abbott Cardiovascular Systems Inc. Scaffolds having radiopaque markers
US9737368B2 (en) 2015-02-24 2017-08-22 Abbott Cardiovascular Systems Inc. System and method for attaching a radiopaque marker bead to an endoprosthesis
JP7064880B2 (en) 2015-04-01 2022-05-11 イェール ユニバーシティー Iron platinum particles for attachment of biologics on medical implants
WO2016161098A1 (en) * 2015-04-02 2016-10-06 Boston Scientific Scimed, Inc. Stent having added feature for strain relief and mitigation of crack propagation
US9700443B2 (en) 2015-06-12 2017-07-11 Abbott Cardiovascular Systems Inc. Methods for attaching a radiopaque marker to a scaffold
DE102015115279A1 (en) * 2015-09-10 2017-03-16 Bentley Innomed Gmbh Expandable vascular support
WO2017100782A1 (en) 2015-12-11 2017-06-15 Research Institute At Nationwide Children's Hospital Systems and methods for optimized patent specific tissue engineering vascular grafts
US11766506B2 (en) 2016-03-04 2023-09-26 Mirus Llc Stent device for spinal fusion
US10849769B2 (en) * 2017-08-23 2020-12-01 Vesper Medical, Inc. Non-foreshortening stent
CN109223253A (en) * 2018-08-16 2019-01-18 河南科技大学第附属医院 A kind of breast prosthesis
CA3126019A1 (en) 2019-01-18 2020-07-23 W. L. Gore & Associates, Inc. Bioabsorbable medical devices
CN115501021B (en) * 2021-06-22 2023-08-11 微创神通医疗科技（上海）有限公司 Support and medicine carrying support
CN115501020A (en) * 2021-06-22 2022-12-23 微创神通医疗科技（上海）有限公司 Support and medicine-carrying support
CN115501018A (en) * 2021-06-22 2022-12-23 微创神通医疗科技（上海）有限公司 Support and medicine-carrying support

Family Cites Families (39)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5810767A (en) * 1994-05-11 1998-09-22 Localmed, Inc. Method and apparatus for pressurized intraluminal drug delivery
US5891108A (en) * 1994-09-12 1999-04-06 Cordis Corporation Drug delivery stent
EP0758216B1 (en) 1995-03-01 2002-07-10 SciMed Life Systems, Inc. Improved longitudinally flexible expandable stent
ATE169484T1 (en) * 1995-04-01 1998-08-15 Variomed Ag STENT FOR TRANSLUMINAL IMPLANTATION IN HOLLOW ORGANS
US6280413B1 (en) * 1995-06-07 2001-08-28 Medtronic Ave, Inc. Thrombolytic filtration and drug delivery catheter with a self-expanding portion
US5895406A (en) * 1996-01-26 1999-04-20 Cordis Corporation Axially flexible stent
US6783543B2 (en) * 2000-06-05 2004-08-31 Scimed Life Systems, Inc. Intravascular stent with increasing coating retaining capacity
US5922020A (en) * 1996-08-02 1999-07-13 Localmed, Inc. Tubular prosthesis having improved expansion and imaging characteristics
DE19653721A1 (en) 1996-10-28 1998-04-30 Biotronik Mess & Therapieg Stent
WO1998018407A1 (en) * 1996-10-28 1998-05-07 BIOTRONIK MESS- UND THERAPIEGERäTE GMBH & CO. INGENIEURBüRO BERLIN Stent
US5843172A (en) * 1997-04-15 1998-12-01 Advanced Cardiovascular Systems, Inc. Porous medicated stent
US6273913B1 (en) * 1997-04-18 2001-08-14 Cordis Corporation Modified stent useful for delivery of drugs along stent strut
DE69729203D1 (en) 1997-07-04 2004-06-24 Alain Fouere FLEXIBLE AND EXPANDABLE, INTERNAL, VASCULAR PROSTHESIS FOR SURGICAL APPLICATION
US6231598B1 (en) * 1997-09-24 2001-05-15 Med Institute, Inc. Radially expandable stent
US6042606A (en) * 1997-09-29 2000-03-28 Cook Incorporated Radially expandable non-axially contracting surgical stent
US5972027A (en) * 1997-09-30 1999-10-26 Scimed Life Systems, Inc Porous stent drug delivery system
US6273908B1 (en) * 1997-10-24 2001-08-14 Robert Ndondo-Lay Stents
EP1028672B2 (en) * 1997-11-07 2011-08-03 Expandable Grafts Partnership Intravascular stent and method for manufacturing an intravascular stent
US6132461A (en) * 1998-03-27 2000-10-17 Intratherapeutics, Inc. Stent with dual support structure
US6241762B1 (en) * 1998-03-30 2001-06-05 Conor Medsystems, Inc. Expandable medical device with ductile hinges
US6206916B1 (en) * 1998-04-15 2001-03-27 Joseph G. Furst Coated intraluminal graft
US20010032011A1 (en) * 1999-07-20 2001-10-18 Stanford Ulf Harry Expandable stent with array of relief cuts
WO2000010622A1 (en) * 1998-08-20 2000-03-02 Cook Incorporated Coated implantable medical device
US6206915B1 (en) * 1998-09-29 2001-03-27 Medtronic Ave, Inc. Drug storing and metering stent
DE60022348T2 (en) * 1999-06-30 2006-02-23 Advanced Cardiovascular Systems, Inc., Santa Clara STENT WITH VARIABLE THICKNESS
US6258121B1 (en) * 1999-07-02 2001-07-10 Scimed Life Systems, Inc. Stent coating
US6379381B1 (en) 1999-09-03 2002-04-30 Advanced Cardiovascular Systems, Inc. Porous prosthesis and a method of depositing substances into the pores
DE60032912T2 (en) * 1999-09-03 2007-10-25 Advanced Cardiovascular Systems, Inc., Santa Clara POROUS PROSTHESIS AND METHOD FOR THE DEPOSITION OF SUBSTANCES IN THE PORES
AU1084101A (en) 1999-10-14 2001-04-23 United Stenting, Inc. Stents with multilayered struts
EP1132058A1 (en) 2000-03-06 2001-09-12 Advanced Laser Applications Holding S.A. Intravascular prothesis
US8252044B1 (en) * 2000-11-17 2012-08-28 Advanced Bio Prosthestic Surfaces, Ltd. Device for in vivo delivery of bioactive agents and method of manufacture thereof
WO2001091918A1 (en) 2000-05-31 2001-12-06 Advanced Cardiovascular Systems, Inc. An apparatus and method for forming a coating onto a surface of a prosthesis
US6254632B1 (en) * 2000-09-28 2001-07-03 Advanced Cardiovascular Systems, Inc. Implantable medical device having protruding surface structures for drug delivery and cover attachment
US6506437B1 (en) * 2000-10-17 2003-01-14 Advanced Cardiovascular Systems, Inc. Methods of coating an implantable device having depots formed in a surface thereof
US6758859B1 (en) * 2000-10-30 2004-07-06 Kenny L. Dang Increased drug-loading and reduced stress drug delivery device
US7077859B2 (en) * 2000-12-22 2006-07-18 Avantec Vascular Corporation Apparatus and methods for variably controlled substance delivery from implanted prostheses
US6635082B1 (en) * 2000-12-29 2003-10-21 Advanced Cardiovascular Systems Inc. Radiopaque stent
US6544582B1 (en) * 2001-01-05 2003-04-08 Advanced Cardiovascular Systems, Inc. Method and apparatus for coating an implantable device
ES2266148T5 (en) * 2001-07-20 2012-11-06 Sorin Biomedica Cardio S.R.L. Stent

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7959664B2 (en) 1996-12-26 2011-06-14 Medinol, Ltd. Flat process of drug coating for stents

Also Published As

Publication number Publication date
EP2255757B1 (en) 2012-12-26
EP2255757A1 (en) 2010-12-01
WO2003047463A1 (en) 2003-06-12
CA2468677C (en) 2010-09-14
US8292945B2 (en) 2012-10-23
EP1448118A1 (en) 2004-08-25
JP4414760B2 (en) 2010-02-10
DE60237302D1 (en) 2010-09-23
EP1448118B1 (en) 2010-08-11
US7014654B2 (en) 2006-03-21
EP2255758B1 (en) 2014-12-31
JP2005511139A (en) 2005-04-28
AU2002365875A1 (en) 2003-06-17
EP2255758A1 (en) 2010-12-01
US20030105511A1 (en) 2003-06-05
US20050278016A1 (en) 2005-12-15

Similar Documents

Publication Publication Date Title
CA2468677A1 (en) Stent designed for the delivery of therapeautic substance or other agents
USD380831S (en) Implantable self-expanding stent
USD485685S1 (en) Camouflage pattern for sheet material
USD429335S (en) Prosthetic liner reinforcement patch
USD485992S1 (en) Camouflage pattern for sheet material
US6395020B1 (en) Stent cell configurations
USD408223S (en) Baking dish with collar
EP1852089A3 (en) Longitudinally flexible expandable stent
EP1233091A8 (en) Knitted fabric
USD438812S1 (en) Expansion bracelet
AU2002243302A1 (en) Stent designs
EP1208814A3 (en) Low profile stent
USD457373S1 (en) Mat
WO2004028571A3 (en) Implantable stent with modified ends
DE69934244D1 (en) SPIRAL STONE
CA2334810A1 (en) Method and device for delivery of therapeutic agents in conjunction with isotope seed placement
USD486650S1 (en) Camouflage pattern for sheet material
USD407949S (en) Scalloped baking dish
USD399310S (en) Surface pattern for disposable absorbent article
USD439111S1 (en) Cup
USD397837S (en) Zippered glove
USD454513S1 (en) Ring
PL365423A1 (en) Periodic structures comprising lipids, polyelectrolytes, and structures-inducing soluble oligovalent linkers
USD432656S (en) Bandage
USD450428S1 (en) Surface pattern for a footwear sole

Legal Events

Date Code Title Description
EEER Examination request
MKLA Lapsed

Effective date: 20131120

MKLA Lapsed

Effective date: 20131120