CA2467867A1 - Apparatus and method for elucidating reaction dynamics of photoreactive compounds from optical signals affected by an external magnetic field - Google Patents
Apparatus and method for elucidating reaction dynamics of photoreactive compounds from optical signals affected by an external magnetic field Download PDFInfo
- Publication number
- CA2467867A1 CA2467867A1 CA002467867A CA2467867A CA2467867A1 CA 2467867 A1 CA2467867 A1 CA 2467867A1 CA 002467867 A CA002467867 A CA 002467867A CA 2467867 A CA2467867 A CA 2467867A CA 2467867 A1 CA2467867 A1 CA 2467867A1
- Authority
- CA
- Canada
- Prior art keywords
- magnetic field
- probe beam
- roi
- applying
- recording
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 238000000034 method Methods 0.000 title claims abstract 13
- 238000006243 chemical reaction Methods 0.000 title claims abstract 5
- 150000001875 compounds Chemical class 0.000 title claims abstract 5
- 230000003287 optical effect Effects 0.000 title claims abstract 3
- 239000000523 sample Substances 0.000 claims abstract 12
- 230000001225 therapeutic effect Effects 0.000 claims 7
- 238000010521 absorption reaction Methods 0.000 claims 3
- 230000001678 irradiating effect Effects 0.000 claims 3
- 238000004020 luminiscence type Methods 0.000 claims 3
- 239000003795 chemical substances by application Substances 0.000 claims 2
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 claims 1
- 230000008081 blood perfusion Effects 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 229940079593 drug Drugs 0.000 claims 1
- 238000001727 in vivo Methods 0.000 claims 1
- 238000005259 measurement Methods 0.000 claims 1
- 229910052760 oxygen Inorganic materials 0.000 claims 1
- 239000001301 oxygen Substances 0.000 claims 1
- 238000006213 oxygenation reaction Methods 0.000 claims 1
- 238000004458 analytical method Methods 0.000 abstract 1
- 239000013307 optical fiber Substances 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue
- A61B5/1455—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue using optical sensors, e.g. spectral photometrical oximeters
- A61B5/14551—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue using optical sensors, e.g. spectral photometrical oximeters for measuring blood gases
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/0059—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N2/00—Magnetotherapy
- A61N2/002—Magnetotherapy in combination with another treatment
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N5/00—Radiation therapy
- A61N5/06—Radiation therapy using light
- A61N5/0613—Apparatus adapted for a specific treatment
- A61N5/062—Photodynamic therapy, i.e. excitation of an agent
Abstract
An apparatus and method for elucidating reaction dynamics of photoreactive compounds from time-resolved optical signals affected by an external magnetic field. The apparatus includes a coil or magnet for applying a magnetic field at a region of interest (ROI). The apparatus further includes a light or laser for illuminating the ROI with a probe beam. An optical fiber collects light emitted by the probe beam; and a computer analyses the collected light.
Claims (17)
1. An apparatus for elucidating reaction dynamics of photoreactive compounds, comprising:
means for applying a magnetic field at a region of interest (ROI);
means for illuminating said ROI with a probe beam;
means for collecting light emitted by said probe beam; and means for analysing said collected light.
means for applying a magnetic field at a region of interest (ROI);
means for illuminating said ROI with a probe beam;
means for collecting light emitted by said probe beam; and means for analysing said collected light.
2. The apparatus according to claim 1, wherein means for applying a magnetic field, and said means for collecting light are placed in a housing.
3. The apparatus of claim 2, wherein said housing further includes means for applying a therapeutic beam.
4. The apparatus of claim 2, wherein said housing includes a pulse oximeter, an oxygen electrode, or both.
5. The apparatus according to claim 1, wherein said means for applying a magnetic field include at least one permanent magnet or at least one coil.
6. The apparatus according to claim 5, wherein said means for applying a magnetic field are adapted be turned on or off; are adapted to be sinusoidally modulated; are adapted to vary a strength of said field over time; or a combination thereof; or are constant.
7. A method for elucidating reaction dynamics of photoreactive compounds in vivo, comprising the steps of:
a) irradiating a ROI with a probe beam;
b) recording the tissue fluorescence, phosphorescence and absorption characteristics at at least one wavelength;
c) administering a photoreactive agent;
d) irradiating the ROI with the probe beam;
e) recording the luminescence intensity and lifetime and absorption characteristics of the ROI at at least one wavelength when B = 0 Tesla;
f) applying a magnetic field of a predetermined strength;
g) recording the luminescence intensity and lifetime and absorption characteristics of the ROI at at least one wavelength when B > 0 Tesla;
h) repeating steps f) and g) for different magnetic field strengths;
i) turning off said probe beam;
j) processing data obtained; and k) displaying results obtained by said processing on a display.
a) irradiating a ROI with a probe beam;
b) recording the tissue fluorescence, phosphorescence and absorption characteristics at at least one wavelength;
c) administering a photoreactive agent;
d) irradiating the ROI with the probe beam;
e) recording the luminescence intensity and lifetime and absorption characteristics of the ROI at at least one wavelength when B = 0 Tesla;
f) applying a magnetic field of a predetermined strength;
g) recording the luminescence intensity and lifetime and absorption characteristics of the ROI at at least one wavelength when B > 0 Tesla;
h) repeating steps f) and g) for different magnetic field strengths;
i) turning off said probe beam;
j) processing data obtained; and k) displaying results obtained by said processing on a display.
8. The method of claim 7, wherein a therapeutic beam is employed, and wherein said method includes the step of turning on the therapeutic beam for a set time then turning it off, then repeating steps d) through i).
9. The method of claim 7, wherein said steps of recording and said step of performing PDT are simultaneous.
10. The method of claim 7, wherein the probe beam and the therapeutic beam are of the same wavelength and are generated from the same source.
11. The method of claim 7, wherein the probe beam and the therapeutic beam are of different wavelengths.
12. The method of claim 7, wherein the probe beam and the therapeutic beam use the same source and wavelength, and where the therapeutic beam is more intense than the probe beam.
13. The method of claim 7, wherein multiple wavelengths are measured at the same time.
14. The method of claim 7, wherein said method further comprises the step of recording the tissues oxygenation and blood perfusion of the ROI either before administering the photoreactive agent; after turning off the probe beam; or both.
15. A method for elucidating reaction dynamics of photoreactive compounds from optical signals affected by an external magnetic field, comprising the steps of calibrating an apparatus as claimed in claim 1; administering a PDT drug;
irradiating a region of interest and performing measurements.
irradiating a region of interest and performing measurements.
16. An apparatus according to claim 1, wherein said means for analysing said collected light are adapted to generate processed data, including luminescence lifetime calculations, difference and ratiometric processing, correlating between at least two variables.
17. An apparatus according to claim 16, wherein said processed data is outputted visually as a map or a graph.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US10/671,704 | 2003-09-26 | ||
| US10/671,704 US7519411B2 (en) | 2003-09-26 | 2003-09-26 | Method for elucidating reaction dynamics of photoreactive compounds from optical signals affected by an external magnetic field |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CA2467867A1 true CA2467867A1 (en) | 2005-03-26 |
| CA2467867C CA2467867C (en) | 2012-01-03 |
Family
ID=34376175
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA2467867A Active CA2467867C (en) | 2003-09-26 | 2004-05-21 | Apparatus and method for elucidating reaction dynamics of photoreactive compounds from optical signals affected by an external magnetic field |
Country Status (2)
| Country | Link |
|---|---|
| US (2) | US7519411B2 (en) |
| CA (1) | CA2467867C (en) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20090116006A1 (en) * | 2005-06-07 | 2009-05-07 | Omron Healthcare Co., Ltd. | Biological information measuring sensor |
| EP1912557A2 (en) * | 2005-08-01 | 2008-04-23 | Philips Intellectual Property & Standards GmbH | Optical imaging |
| US7986989B2 (en) * | 2005-09-29 | 2011-07-26 | The Research Foundation Of The City University Of New York | Phosphorescence and fluorescence spectroscopy for detection of cancer and pre-cancer from normal/benign regions |
| ES2715633T3 (en) | 2008-05-20 | 2019-06-05 | Univ Health Network | Device and method for imaging and fluorescence monitoring |
| US20100124905A1 (en) * | 2008-11-14 | 2010-05-20 | At&T Mobility Ii Llc | Systems and Methods for Message Forwarding |
| CA2764028A1 (en) * | 2009-06-05 | 2010-12-09 | Institut National D'optique | Hybrid-multimodal magneto-optical contrast marker |
| WO2010139071A1 (en) * | 2009-06-05 | 2010-12-09 | Institut National D'optique | Hybridized optical-mri method and device for molecular dynamic monitoring of in vivo response to disease treatment |
| US9459210B2 (en) * | 2012-05-08 | 2016-10-04 | University Of Calcutta | Static magnetic field induced differential fluorescence emission |
| EP3957232A1 (en) | 2014-07-24 | 2022-02-23 | University Health Network | Collection and analysis of data for diagnostic purposes |
| US11344740B2 (en) | 2019-02-07 | 2022-05-31 | Asha Medical, Inc. | System and methods for treating cancer cells with alternating polarity magnetic fields |
| JP2022519782A (en) | 2019-02-07 | 2022-03-24 | ヴィヴェーク・ケー・シャルマ | Systems and methods for treating cancer cells with alternating polar magnetic fields |
| US11027143B2 (en) | 2020-02-06 | 2021-06-08 | Vivek K. Sharma | System and methods for treating cancer cells with alternating polarity magnetic fields |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5853370A (en) * | 1996-09-13 | 1998-12-29 | Non-Invasive Technology, Inc. | Optical system and method for non-invasive imaging of biological tissue |
| US6544193B2 (en) * | 1996-09-04 | 2003-04-08 | Marcio Marc Abreu | Noninvasive measurement of chemical substances |
| US5921244A (en) * | 1997-06-11 | 1999-07-13 | Light Sciences Limited Partnership | Internal magnetic device to enhance drug therapy |
| US6128525A (en) * | 1997-07-29 | 2000-10-03 | Zeng; Haishan | Apparatus and method to monitor photodynamic therapy (PDT) |
| US6514277B1 (en) * | 1999-06-11 | 2003-02-04 | Photonics Research Ontario | Fiber optic multitasking probe |
| US20030083537A1 (en) * | 2001-02-28 | 2003-05-01 | Vincent Ardizzone | Bi-axial rotating magnetic therapeutic device |
| US6679827B2 (en) * | 2001-10-11 | 2004-01-20 | Robert E. Sandstrom | Magnetic field enhancement of tumor treatment |
-
2003
- 2003-09-26 US US10/671,704 patent/US7519411B2/en active Active
-
2004
- 2004-05-21 CA CA2467867A patent/CA2467867C/en active Active
-
2009
- 2009-03-05 US US12/398,593 patent/US8005528B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| US20050069497A1 (en) | 2005-03-31 |
| CA2467867C (en) | 2012-01-03 |
| US8005528B2 (en) | 2011-08-23 |
| US7519411B2 (en) | 2009-04-14 |
| US20090198114A1 (en) | 2009-08-06 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EEER | Examination request |