CA2461873A1 - Systems, methods and apparatuses for manufacturing dosage forms - Google Patents
Systems, methods and apparatuses for manufacturing dosage forms Download PDFInfo
- Publication number
- CA2461873A1 CA2461873A1 CA002461873A CA2461873A CA2461873A1 CA 2461873 A1 CA2461873 A1 CA 2461873A1 CA 002461873 A CA002461873 A CA 002461873A CA 2461873 A CA2461873 A CA 2461873A CA 2461873 A1 CA2461873 A1 CA 2461873A1
- Authority
- CA
- Canada
- Prior art keywords
- dosage form
- mold cavity
- flowable material
- mold
- compressed dosage
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23G—COCOA; COCOA PRODUCTS, e.g. CHOCOLATE; SUBSTITUTES FOR COCOA OR COCOA PRODUCTS; CONFECTIONERY; CHEWING GUM; ICE-CREAM; PREPARATION THEREOF
- A23G3/00—Sweetmeats; Confectionery; Marzipan; Coated or filled products
- A23G3/34—Sweetmeats, confectionery or marzipan; Processes for the preparation thereof
- A23G3/36—Sweetmeats, confectionery or marzipan; Processes for the preparation thereof characterised by the composition containing organic or inorganic compounds
- A23G3/364—Sweetmeats, confectionery or marzipan; Processes for the preparation thereof characterised by the composition containing organic or inorganic compounds containing microorganisms or enzymes; containing paramedical or dietetical agents, e.g. vitamins
- A23G3/368—Sweetmeats, confectionery or marzipan; Processes for the preparation thereof characterised by the composition containing organic or inorganic compounds containing microorganisms or enzymes; containing paramedical or dietetical agents, e.g. vitamins containing vitamins, antibiotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
- A61J3/00—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms
- A61J3/10—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms into the form of compressed tablets
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23G—COCOA; COCOA PRODUCTS, e.g. CHOCOLATE; SUBSTITUTES FOR COCOA OR COCOA PRODUCTS; CONFECTIONERY; CHEWING GUM; ICE-CREAM; PREPARATION THEREOF
- A23G3/00—Sweetmeats; Confectionery; Marzipan; Coated or filled products
- A23G3/02—Apparatus specially adapted for manufacture or treatment of sweetmeats or confectionery; Accessories therefor
- A23G3/04—Sugar-cookers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
- A61J3/00—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms
- A61J3/005—Coating of tablets or the like
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B30—PRESSES
- B30B—PRESSES IN GENERAL
- B30B11/00—Presses specially adapted for forming shaped articles from material in particulate or plastic state, e.g. briquetting presses, tabletting presses
- B30B11/005—Control arrangements
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B30—PRESSES
- B30B—PRESSES IN GENERAL
- B30B15/00—Details of, or accessories for, presses; Auxiliary measures in connection with pressing
- B30B15/0005—Details of, or accessories for, presses; Auxiliary measures in connection with pressing for briquetting presses
- B30B15/0017—Deairing means
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
- A61J3/00—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms
- A61J3/06—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms into the form of pills, lozenges or dragees
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
- A61K9/2806—Coating materials
- A61K9/2833—Organic macromolecular compounds
- A61K9/2853—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, polyethylene oxide, poloxamers, poly(lactide-co-glycolide)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
- A61K9/2806—Coating materials
- A61K9/2833—Organic macromolecular compounds
- A61K9/2873—Proteins, e.g. gelatin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
- A61K9/2893—Tablet coating processes
Abstract
Systems, methods and apparatuses for manufacturing dosage forms, and to dosage forms made using such systems, methods and apparatuses are provided.
Compression, thermal cycle molding, and thermal setting molding modules are disclosed. One or more of such modules may be linked, preferably via novel transfer device, into an overall system for making dosage forms.
Compression, thermal cycle molding, and thermal setting molding modules are disclosed. One or more of such modules may be linked, preferably via novel transfer device, into an overall system for making dosage forms.
Claims (137)
1. A method of making a dosage form containing a first medicant, which comprises a) injecting through a nozzle a flowable material containing said first medicant into a mold cavity; and b) hardening said flowable material into a molded dosage form having a shape substantially the same as the mold cavity.
2. The method of claim 1, further comprising the step of heating said flowable material prior to injecting said flowable material into said mold cavity, and wherein said hardening step (b) comprises cooling said flowable material.
3. The method according to claim 2, wherein said mold cavity is heated prior to said injecting step (a) and cooled during said hardening step (b).
4. The method according to claim 3, wherein said mold cavity is heated and cooled using heat transfer fluids that circulate proximal to said mold cavity.
5. The method of claim 2, wherein said mold cavity is heated prior to said injection step (a) and cooled during said hardening step (b) using a single heat transfer fluid heated by a heat source and cooled by a heat sink.
6. The method according to claim 1, wherein said flowable material comprises a polymer.
7. The method according to claim 1, wherein said flowable material comprises a carbohydrate.
8. The method according to claim 1, wherein said flowable material comprises a fat.
9. The method according to claim 1, wherein said flowable material comprises a wax.
10. The method according to claim 1, wherein said flowable material comprises gelatin.
11. The method according to claim 10, further comprising heating said gelatin to a temperature above its gel point prior to said injecting step (a), and wherein said hardening step (b) comprises cooling said gelatin to a temperature below its gel point.
12. The method of claim 1, wherein said molded dosage form is substantially free of visible defects.
13. The method of claim 1, wherein substantially all of the flowable material injected into the mold cavity becomes part of the molded dosage form.
14. The method according to claim 1, further comprising the step of placing an insert in said mold cavity prior to said injecting step (a), such that said molded dosage form comprises an insert embedded therein.
15. The method according to claim 14, wherein said insert comprises a polymer.
16. The method according to claim 14, wherein said insert comprises a carbohydrate.
17. The method according to claim 14, wherein said insert comprises a fat.
18. The method according to claim 14, wherein said insert comprises a wax.
19. The method according to claim 14, wherein said insert comprises a second medicant.
20. The method according to claim 1 performed while said mold cavity is traveling along a circular path.
21. A method of making a molded dosage form which comprises a) heating a flowable material;
b) injecting said flowable material through an orifice into a mold cavity; and c) hardening said flowable material into a molded dosage form having a shape substantially the same as the mold cavity;
wherein said hardening step (c) comprises cooling said flowable material and wherein said mold cavity is heated prior to said injecting step (b) and cooled during said hardening step (c).
b) injecting said flowable material through an orifice into a mold cavity; and c) hardening said flowable material into a molded dosage form having a shape substantially the same as the mold cavity;
wherein said hardening step (c) comprises cooling said flowable material and wherein said mold cavity is heated prior to said injecting step (b) and cooled during said hardening step (c).
22. The method of claim 21, wherein a medicant is introduced into the mold cavity prior to said hardening step (c).
23. A molded dosage form made according to the method of claim 21 substantially free of visible defects.
24. A method of coating a substrate, comprising the steps of:
a) enclosing at least a portion of said substrate in a mold cavity;
b) injecting a flowable material into said mold cavity so as to coat at least a portion of said substrate with said flowable material; and c) hardening said flowable material to form a coating over at least a portion of said substrate.
a) enclosing at least a portion of said substrate in a mold cavity;
b) injecting a flowable material into said mold cavity so as to coat at least a portion of said substrate with said flowable material; and c) hardening said flowable material to form a coating over at least a portion of said substrate.
25. The method of claim 24, further comprising the step of heating said flowable material prior to said injecting step (b), and wherein said hardening step (c) comprises cooling said flowable material.
26. The method according to claim 25, wherein said mold cavity is heated prior to said injecting step (b) and cooled during said hardening step (c).
27. The method according to claim 26, wherein said mold cavity is heated and cooled using heat transfer fluids that circulate proximal to said mold cavity.
28. The method of claim 25, wherein said mold cavity is heated prior to said injecting step (b) and cooled during said hardening step (c) using a single heat transfer fluid heated by a heat source and cooled by a heat sink.
29. The method according to claim 24, wherein said flowable material comprises a polymer.
30. The method according to claim 24, wherein said flowable material comprises a carbohydrate.
31. The method according to claim 24, wherein said flowable material comprises a fat.
32. The method according to claim 24, wherein said flowable material comprises a wax.
33. The method according to claim 24, wherein said flowable material comprises gelatin.
34. The method according to claim 33, further comprising heating said gelatin to a temperature above its gel point prior to said injecting step (b), and wherein said hardening step (c) comprises cooling said gelatin to a temperature below its gel point.
35. The method of claim 24, wherein said molded dosage form is substantially free of visible defects.
36. The method of claim 24, wherein substantially all of the flowable material injected into the mold cavity becomes part of the molded dosage form.
37. The method of claim 24, wherein said substrate is a compressed dosage form.
38. The method according to claim 37, wherein said compressed dosage form is prepared by the steps of:
(i) placing a supply of powder in flow communication with a die, said die comprising a die cavity therein;
(ii) applying suction to said die cavity so as to cause powder to flow into said die cavity; and (iii) compressing said powder in said die cavity so as to form a compressed dosage form.
(i) placing a supply of powder in flow communication with a die, said die comprising a die cavity therein;
(ii) applying suction to said die cavity so as to cause powder to flow into said die cavity; and (iii) compressing said powder in said die cavity so as to form a compressed dosage form.
39. The method of according to claim 37, wherein said compressed dosage form comprises a first medicant.
40. The method according to claim 24 performed while said mold cavity is traveling along a circular path.
41. The method according to claim 24 performed while said mold cavity is traveling along a helical path.
42. The method according to claim 37, wherein said compressed dosage form comprises an insert embedded therein.
43. The method according to claim 42, wherein said insert comprises a thermal-setting material.
44. The method of claim 42, wherein said insert comprises a second medicant.
45. The method according to claim 24, wherein said flowable material comprises a third medicant.
46. A method of applying at least one flowable material to a substrate having first and second portions comprising:
masking said first portion of said substrate;
exposing said second portion to a mold cavity;
injecting said flowable material onto said second portion; and hardening said flowable material on said second portion of said substrate.
masking said first portion of said substrate;
exposing said second portion to a mold cavity;
injecting said flowable material onto said second portion; and hardening said flowable material on said second portion of said substrate.
47. A method of applying at least one flowable material to a substrate having first and second portions comprising:
exposing said first portion to a first mold cavity;
injecting said flowable material onto said first portion;
hardening said flowable material on said first portion of said substrate;
retaining said first portion in said first mold cavity.
exposing said first portion to a first mold cavity;
injecting said flowable material onto said first portion;
hardening said flowable material on said first portion of said substrate;
retaining said first portion in said first mold cavity.
48. The method according to claim 47, further comprising the steps of:
transporting said first mold cavity while said first portion is retained therein to a remote location.
transporting said first mold cavity while said first portion is retained therein to a remote location.
49. A method of coating a substrate with first and second flowable materials, comprising the steps of:
a) enclosing a first portion of said substrate in a first mold cavity;
b) injecting a first flowable material into said first mold cavity so as to coat said first portion with said first flowable material;
c) hardening said first flowable material to form a coating over said first portion;
d) enclosing a second portion of said substrate in a second mold cavity;
e) injecting a second flowable material into said second mold cavity so as to coat said second portion with said second flowable material; and f) hardening said second flowable material to form a coating over said second portion.
a) enclosing a first portion of said substrate in a first mold cavity;
b) injecting a first flowable material into said first mold cavity so as to coat said first portion with said first flowable material;
c) hardening said first flowable material to form a coating over said first portion;
d) enclosing a second portion of said substrate in a second mold cavity;
e) injecting a second flowable material into said second mold cavity so as to coat said second portion with said second flowable material; and f) hardening said second flowable material to form a coating over said second portion.
50. The method according to claim 49, further comprising the steps of:
g) heating said first mold cavity prior to said injection step (b), whereby said first flowable material is injected into a heated mold cavity;
h) cooling said first mold cavity after said injecting step (b);
i) heating said second mold cavity prior to said injection step (e), whereby said second flowable material is also injected into a heated mold cavity; and j) cooling said second mold cavity after said injecting step (e).
g) heating said first mold cavity prior to said injection step (b), whereby said first flowable material is injected into a heated mold cavity;
h) cooling said first mold cavity after said injecting step (b);
i) heating said second mold cavity prior to said injection step (e), whereby said second flowable material is also injected into a heated mold cavity; and j) cooling said second mold cavity after said injecting step (e).
51. The method according to claim 50, wherein said first and second mold cavities are heated during said injecting steps (b) and (e), respectively, and cooled during said hardening steps (c) and (f), respectively.
52. The method according to claim 51, wherein said mold cavities are heated and cooled using heat transfer fluids that circulate proximal to said mold cavities.
53. The method according to claim 49, wherein said first mold cavity travels degrees in a circular path during said injection step (b) and said second mold cavity travels 360 degrees in a circular path during said injection step (e).
54. The method according to claim 49, wherein a single center mold assembly is used for said injection steps (b) and (e).
55. The method according to claim 49, wherein said injection steps (b) and (e) are performed simultaneously in upper and lower mold assemblies connected to a single center mold assembly.
56. The method according to claim 49, wherein said first and second flowable materials comprise gelatin, and said gelatin is heated to a temperature above its gel point prior to said injecting steps (b) and (e), and wherein said hardening steps (c) and (f) comprise cooling said gelatin to a temperature below its gel point.
57. The method according to claim 49, wherein said first and second flowable materials are different colors.
58. The method according to claim 49, wherein said injecting step (b) further comprises sealing said second portion of said compressed dosage form so as to provide a boundary between said first flowable material and said second portion.
59. The method according to claim 49, wherein said substrate is a compressed dosage form.
60. The method according to claim 59, wherein said compressed dosage form is prepared by the steps of:
(i) placing a supply of powder in flow communication with a die, said die comprising a die cavity therein;
(ii) applying suction to said die cavity so as to cause powder to flow into said die cavity; and (iii) compressing said powder in said die cavity so as to form a compressed dosage form.
(i) placing a supply of powder in flow communication with a die, said die comprising a die cavity therein;
(ii) applying suction to said die cavity so as to cause powder to flow into said die cavity; and (iii) compressing said powder in said die cavity so as to form a compressed dosage form.
61. The method according to claim 59, wherein said compressed dosage form comprises a first medicant.
62. The method according to claim 49 performed while said mold cavities are traveling along a circular path.
63. The method according to claim 49 performed while said mold cavities are traveling along a helical path.
64. The method according to claim 59, wherein said compressed dosage form comprises an insert embedded therein.
65. The method according to claim 64, wherein said insert comprises a thermal-setting material.
66. The method of claim 64, wherein said insert comprises a second medicant.
67. The method according to claim 49, wherein said at least one or said first or second flowable materials comprises a third medicant.
68. An apparatus for molding substrates comprising a plurality of mold cavities, each mold cavity having an internal surface and comprising an orifice for delivering flowable material to said mold cavity, said orifice being matable with a valve tip that in its closed position forms part of said internal surface.
69. An apparatus for molding substrates comprising a plurality of mold cavities, a heat source, a heat sink, and a temperature control system, said temperature control system comprising a tubing system disposed proximal to said mold cavities and connected to said heat source and said heat sink for circulating heat transfer fluid through said heat source, through said heat sink, and proximal to said mold cavities, such that said mold cavities may be heated and cooled by said heat transfer fluid.
70. The apparatus of claim 69, wherein said tubing system further comprises a common flow passageway between said heat sink and said heat source, an energy recovery vessel in fluid communication with said common flow passageway, a plurality of valves disposed in said tubing system between a) said common flow passageway and said heat source and b) said common flow passageway and said heat sink, and a control system for controlling said valves, such that upon activation of said valves by said control system, heat transfer fluid contained in said common flow passageway is transferred to said energy recovery vessel.
71. The apparatus of claim 70, wherein said energy recovery vessel comprises a fluid reservoir bisected by a piston.
72. The apparatus of claim 70, wherein said energy recovery vessel comprises a hot bladder and a cold bladder.
73. The apparatus of claim 68 further comprising a rotor capable of rotation about a central axis, said mold cavities being disposed around the circumference of said rotor.
74. The apparatus of claim 69, wherein said mold cavities are heated and cooled over a temperature range of about 0 to 100° C in about 1 to 30 seconds.
75. The apparatus of claim 69, wherein the mass and geometry of said mold cavities are such as to have a negligible effect on the time in which said mold cavities are heated and cooled.
76. A nozzle system for a molding apparatus, comprising a nozzle and an ejector means, said nozzle surrounding and being concentric with said ejector means.
77. The nozzle system of claim 76, wherein said ejector means comprises an ejector pin.
78. The nozzle system of claim 76, wherein said ejector means comprises an air passage and said nozzles are retractable.
79. An apparatus for coating compressed dosage forms, comprising:
a) a mold cavity for enclosing at least a first portion of said compressed dosage form;
b) means for injecting a flowable material into said mold cavity to coat at least said first portion of said compressed dosage form with said flowable material;
and c) means for hardening said flowable material so as to form a coating over at least said first portion said compressed dosage form.
a) a mold cavity for enclosing at least a first portion of said compressed dosage form;
b) means for injecting a flowable material into said mold cavity to coat at least said first portion of said compressed dosage form with said flowable material;
and c) means for hardening said flowable material so as to form a coating over at least said first portion said compressed dosage form.
80. The apparatus according to claim 79, further comprising (d) means for heating said mold cavity prior to injecting said flowable material into said mold cavity, wherein said hardening means (c) comprises means for cooling said mold cavity.
81. The apparatus according to claim 80, wherein said heating means (d) and said hardening means (c) comprise a heat source, a heat sink, and a temperature control system, said temperature control system comprising a tubing system disposed proximal to said mold cavities and connected to said heat source and said heat sink for circulating heat transfer fluid through said heat source, through said heat sink, and proximal to said mold cavities, such that said mold cavities may be heated and cooled by said heat transfer fluid.
82. The apparatus according to claim 79, wherein said flowable material is a first flowable material and said mold cavity is a first mold cavity, said apparatus further comprising:
e) a second mold cavity for enclosing a second portion of said compressed dosage form;
f) means for injecting a second flowable material into said second mold cavity to coat said second portion of said compressed dosage form with said second flowable material; and g) means for hardening said second flowable material so as to form a coating over said second portion of said compressed dosage form.
e) a second mold cavity for enclosing a second portion of said compressed dosage form;
f) means for injecting a second flowable material into said second mold cavity to coat said second portion of said compressed dosage form with said second flowable material; and g) means for hardening said second flowable material so as to form a coating over said second portion of said compressed dosage form.
83. The apparatus according to claim 82, wherein said first and second flowable materials are different colors.
84. The apparatus according to claim 82, further comprising first means for sealing said second portion of said compressed dosage form while said first portion of said compressed dosage form is being coated, and second means for sealing said first portion of said compressed dosage form while said second portion of said compressed dosage form is being coated.
85. The apparatus according to claim 84, wherein said first and second sealing means are elastomeric collets.
86. The apparatus according to claim 85, wherein said elastomeric collets comprise vents allowing air to escape from said mold cavities during injection of flowable material into said mold cavities.
87. The apparatus according to claim 85, wherein said elastomeric collets comprise a plurality of flexible fingers, said elastomeric collets being attached to a movable support stem, said flexible fingers opening and closing in a radial direction upon movement of said support stem.
88. An apparatus for coating a compressed dosage form having a first portion and a second portion, comprising:
a) a mold cavity for enclosing said first portion of said compressed dosage form;
b) a nozzle for injecting a flowable material into said mold cavity to coat said first portion of said compressed dosage form with said flowable material;
c) a temperature control system capable of heating and cooling said mold cavity;
and d) an elastomeric collet for sealing said second portion of said compressed dosage form while said first portion of said compressed dosage form is being coated.
a) a mold cavity for enclosing said first portion of said compressed dosage form;
b) a nozzle for injecting a flowable material into said mold cavity to coat said first portion of said compressed dosage form with said flowable material;
c) a temperature control system capable of heating and cooling said mold cavity;
and d) an elastomeric collet for sealing said second portion of said compressed dosage form while said first portion of said compressed dosage form is being coated.
89. The apparatus of claim 88, further comprising a heat source and a heat sink, said temperature control system comprising a tubing system disposed proximal to said mold cavity and connected to said heat source and said heat sink for circulating heat transfer fluid through said heat source, through said heat sink, and proximal to said mold cavity, such that said mold cavity may be heated and cooled by said heat transfer fluid.
90. The apparatus of claim 89, wherein said tubing system further comprises a common flow passageway between said heat sink and said heat source, an energy recovery vessel in fluid communication with said common flow passageway, a plurality of valves disposed in said tubing system between a) said common flow passageway and said heat source and b) said common flow passageway and said heat sink, and a control system for controlling said valves, such that upon activation of said valves by said control system, heat transfer fluid contained in said common flow passageway is transferred to said energy recovery vessel.
91. The apparatus of claim 90, wherein said energy recovery vessel comprises a fluid reservoir bisected by a piston.
92. The apparatus of claim 90, wherein said energy recovery vessel comprises a hot bladder and a cold bladder.
93. The apparatus according to claim 88, wherein said flowable material is a first flowable material and said mold cavity is a first mold cavity, said apparatus further comprising:
e) a second mold cavity for enclosing said second portion of said compressed dosage form;
f) a second nozzle for injecting a second flowable material into said second mold cavity to coat said second portion of said compressed dosage form with said second flowable material; and g) a second elastomeric collet for sealing said first portion of said compressed dosage form while said second portion of said compressed dosage form is being coated, wherein said temperature control system is also capable of heating and cooling said second mold cavity.
e) a second mold cavity for enclosing said second portion of said compressed dosage form;
f) a second nozzle for injecting a second flowable material into said second mold cavity to coat said second portion of said compressed dosage form with said second flowable material; and g) a second elastomeric collet for sealing said first portion of said compressed dosage form while said second portion of said compressed dosage form is being coated, wherein said temperature control system is also capable of heating and cooling said second mold cavity.
94. The apparatus according to claim 88, wherein said elastomeric collet comprises vents allowing air to escape from said mold cavity during injection of flowable material into said mold cavity.
95. The apparatus according to claim 88, wherein said elastomeric collet comprises a plurality of flexible fingers, said elastomeric collet being attached to a movable support stem, said flexible fingers opening and closing in a radial direction upon movement of said support stem.
96. A molding module for molding coatings onto compressed dosage forms, comprising a rotor capable of rotating about a central axis and a plurality of mold units mounted thereon, each mold unit comprising:
a) a mold cavity for enclosing at least a first portion of said compressed dosage form;
b) means for injecting a flowable material into said mold cavity to coat at least said first portion of said compressed dosage form with said flowable material;
and c) means for hardening said flowable material so as to form a coating over at least said first portion said compressed dosage form.
a) a mold cavity for enclosing at least a first portion of said compressed dosage form;
b) means for injecting a flowable material into said mold cavity to coat at least said first portion of said compressed dosage form with said flowable material;
and c) means for hardening said flowable material so as to form a coating over at least said first portion said compressed dosage form.
97. The molding module according to claim 96, further comprising (d) means for heating said mold cavity prior to injecting said flowable material into said mold cavity, wherein said hardening means (c) comprises means for cooling said mold cavity.
98. The molding module according to claim 97, wherein said heating means (d) and said hardening means (c) comprise a heat source, a heat sink, and a temperature control system, said temperature control system comprising a tubing system disposed proximal to said mold cavities and connected to said heat source and said heat sink for circulating heat transfer fluid through said heat source, through said heat sink, and proximal to said mold cavities, such that said mold cavities may be heated and cooled by said heat transfer fluid.
99. The molding module according to claim 96, wherein said flowable material is a first flowable material and said mold cavity is a first mold cavity, said mold unit further comprising:
e) a second mold cavity for enclosing a second portion of said compressed dosage form;
f) means for injecting a second flowable material into said second mold cavity to coat said second portion of said compressed dosage form with said second flowable material; and g) means for hardening said second flowable material so as to form a coating over said second portion of said compressed dosage form.
e) a second mold cavity for enclosing a second portion of said compressed dosage form;
f) means for injecting a second flowable material into said second mold cavity to coat said second portion of said compressed dosage form with said second flowable material; and g) means for hardening said second flowable material so as to form a coating over said second portion of said compressed dosage form.
100. The molding module according to claim 99, wherein said first and second flowable materials are different colors.
101. The molding module according to claim 99, further comprising first means for sealing said second portion of said compressed dosage form while said first portion of said compressed dosage form is being coated, and second means for sealing said first portion of said compressed dosage form while said second portion of said compressed dosage form is being coated.
102. The molding module according to claim 101, wherein said first and second sealing means are elastomeric collets.
103. The molding module according to claim 102, wherein said elastomeric collets comprise vents allowing air to escape from said mold cavities during injection of flowable material into said mold cavities.
104. The molding module according to claim 102, wherein said elastomeric collets comprise a plurality of flexible fingers, said elastomeric collets being attached to a movable support stem, said flexible fingers opening and closing in a radial direction upon movement of said support stem.
105. A molding module for coating a compressed dosage form having a first portion and a second portion, comprising a rotor capable of rotating about a central axis and a plurality of mold units mounted thereon, each mold unit comprising:
a) a mold cavity for enclosing said first portion of said compressed dosage form;
b) a nozzle for injecting a flowable material into said mold cavity to coat said first portion of said compressed dosage form with said flowable material;
c) a temperature control system capable of heating and cooling said mold cavity;
and d) an elastomeric collet for sealing said second portion of said compressed dosage form while said first portion of said compressed dosage form is being coated.
a) a mold cavity for enclosing said first portion of said compressed dosage form;
b) a nozzle for injecting a flowable material into said mold cavity to coat said first portion of said compressed dosage form with said flowable material;
c) a temperature control system capable of heating and cooling said mold cavity;
and d) an elastomeric collet for sealing said second portion of said compressed dosage form while said first portion of said compressed dosage form is being coated.
106. The molding module of claim 105, further comprising a heat source and a heat sink, said temperature control system comprising a tubing system disposed proximal to said mold cavity and connected to said heat source and said heat sink for circulating heat transfer fluid through said heat source, through said heat sink, and proximal to said mold cavity, such that said mold cavity may be heated and cooled by said heat transfer fluid.
107. The molding module of claim 106, wherein said tubing system further comprises a common flow passageway between said heat sink and said heat source, an energy recovery vessel in fluid communication with said common flow passageway, a plurality of valves disposed in said tubing system between a) said common flow passageway and said heat source and b) said common flow passageway and said heat sink, and a control system for controlling said valves, such that upon activation of said valves by said control system, heat transfer fluid contained in said common flow passageway is transferred to said energy recovery vessel.
108. The molding module of claim 107, wherein said energy recovery vessel comprises a fluid reservoir bisected by a piston.
109. The molding module of claim 107, wherein said energy recovery vessel comprises a hot bladder and a cold bladder.
110. The molding module according to claim 105, wherein said flowable material is a first flowable material and said mold cavity is a first mold cavity, said mold unit further comprising:
e) a second mold cavity for enclosing said second portion of said compressed dosage form;
f) a second nozzle for injecting a second flowable material into said second mold cavity to coat said second portion of said compressed dosage form with said second flowable material; and g) a second elastomeric collet for sealing said first portion of said compressed dosage form while said second portion of said compressed dosage form is being coated, wherein said temperature control system is also capable of heating and cooling said second mold cavity.
e) a second mold cavity for enclosing said second portion of said compressed dosage form;
f) a second nozzle for injecting a second flowable material into said second mold cavity to coat said second portion of said compressed dosage form with said second flowable material; and g) a second elastomeric collet for sealing said first portion of said compressed dosage form while said second portion of said compressed dosage form is being coated, wherein said temperature control system is also capable of heating and cooling said second mold cavity.
111. The molding module according to claim 105, wherein said elastomeric collet comprises vents allowing air to escape from said mold cavity during injection of flowable material into said mold cavity.
112. The molding module according to claim 105, wherein said elastomeric collet comprises a plurality of flexible fingers, said elastomeric collet being attached to a movable support stem, said flexible fingers opening and closing in a radial direction upon movement of said support stem.
113. An apparatus for coating compressed dosage forms, comprising:
a) a lower retainer comprising a plurality of collets mounted therein;
b) a center mold assembly comprising first and second groups of insert assemblies mounted on opposing sides thereof, each of said insert assemblies of said first group aligned with and facing one of said collets, said lower retainer and said center mold assembly mounted for relative movement so as to bring said first group of insert assemblies into engagement with said collets;
c) an upper mold assembly comprising upper insert assemblies mounted therein, each of said upper insert assemblies aligned with and facing one of said insert assemblies of said second group, said upper mold assembly and said center mold assembly mounted for relative movement so as to bring said upper insert assemblies into engagement with said second group of insert assemblies.
d) a supply of flowable material; and e) a first passage placing said supply of flowable material in flow communication with said first and second group of insert assemblies, and a valve actuator assembly for controlling the flow of said flowable material to said first and second groups of insert assemblies.
a) a lower retainer comprising a plurality of collets mounted therein;
b) a center mold assembly comprising first and second groups of insert assemblies mounted on opposing sides thereof, each of said insert assemblies of said first group aligned with and facing one of said collets, said lower retainer and said center mold assembly mounted for relative movement so as to bring said first group of insert assemblies into engagement with said collets;
c) an upper mold assembly comprising upper insert assemblies mounted therein, each of said upper insert assemblies aligned with and facing one of said insert assemblies of said second group, said upper mold assembly and said center mold assembly mounted for relative movement so as to bring said upper insert assemblies into engagement with said second group of insert assemblies.
d) a supply of flowable material; and e) a first passage placing said supply of flowable material in flow communication with said first and second group of insert assemblies, and a valve actuator assembly for controlling the flow of said flowable material to said first and second groups of insert assemblies.
114. The apparatus according to claim 113, wherein said lower retainer, center mold assembly and upper mold assembly are mounted to a rotor that is capable of rotation about a first axis.
115. The apparatus according to claim 114, wherein said center mold assembly is mounted for rotation about a second axis, said second axis lying in a plane perpendicular to said first axis, whereby rotation of said center mold assembly about said second axis places each of said insert assemblies in said second group into alignment with and facing one of said collets in said first rotor and places each of said insert assemblies in said first group into alignment with and facing one of said upper insert assemblies in said third rotor.
116. The apparatus according to claim 113, further comprising means for successively heating and then cooling each of said insert assemblies in said center mold assembly.
117. The apparatus according to claim 113, further comprising:
f) a supply of heating fluid;
g) a supply of cooling fluid;
h) second and third passages in heat flow communication with said first and second groups of insert assemblies, respectively, each of said second and third passages in fluid flow communication with said supplies of heating fluid and cooling fluid;
i) third and fourth valves for controlling the flow of heating fluid from said heating fluid supply to second and third passages, respectively;
j) fifth and sixth valves for controlling the flow of cooling fluid from said cooling fluid supply to said second and third passages, respectively.
f) a supply of heating fluid;
g) a supply of cooling fluid;
h) second and third passages in heat flow communication with said first and second groups of insert assemblies, respectively, each of said second and third passages in fluid flow communication with said supplies of heating fluid and cooling fluid;
i) third and fourth valves for controlling the flow of heating fluid from said heating fluid supply to second and third passages, respectively;
j) fifth and sixth valves for controlling the flow of cooling fluid from said cooling fluid supply to said second and third passages, respectively.
118. The apparatus according to claim 113, further comprising a flexible seal disposed in each of said collets for isolating said collets from said first group of insert assemblies when said first group of said insert assemblies is brought into engagement with said collets.
119. The apparatus of claim 113, wherein said valve actuator assembly feeds flowable material to only those insert assemblies of the first and second groups of insert assemblies that are facing said lower retainer.
120. The apparatus of claim 113 further comprising an air actuator assembly for controlling the flow of air to said first and second groups of insert assemblies, said air actuator assembly feeding air only to those insert assemblies of the first and second groups of insert assemblies that are facing said upper mold assembly.
121. A dosage form comprising a substrate having an injection molded coating surrounding at least a portion of the substrate.
122. The dosage form of claim 121, wherein said injection molded coating is substantially free of visible defects.
123. A dosage form comprising a substrate having a thermal cycle molded material disposed on at least a portion of the substrate.
124. A dosage form comprising a substrate having a coating thereon, said coating having a thickness of about 100 to about 400 microns; the relative standard deviation in thickness of said coating being less than 30% ; wherein said coating is substantially free of humectants.
125. A dosage form comprising a tablet having a coating thereon, said coating having a thickness of about 100 to about 400 microns, wherein the relative standard deviation in thickness of said dosage form is not more than about 0.35% ; and wherein said coating is substantially free of humectants.
126. The dosage form of claim 125 having a thickness of about 4 to about 10 mm.
127. The dosage form according to claim 125, wherein the diameter of said dosage form is from about 5 to about 15 mm; wherein the relative standard deviation in said diameter is not more than about 0.35%.
128. The dosage form of claim 124, wherein said coating comprises a first portion of a first color; and a second portion of a second color different from said first color.
129. The dosage form of claim 128, wherein said first and second portions meet to form a seam circumscribing said dosage form about midway along a longitudinal axis of said dosage form.
130. The dosage form of claim 128, wherein said first and second portions meet to form a seam circumscribing said dosage form about midway along a radial axis of said dosage form.
131. The dosage form of claim 124, wherein the substrate comprises a compressed dosage form.
132. The dosage form of claim 124, wherein the substrate comprises a capsule.
133. The dosage form of claim 124, wherein the substrate comprises a medicant.
134. The dosage form of claim 124, wherein the coating comprises a medicant.
135. The dosage form of claim 124, wherein the compressed dosage form has a hardness prior to coating of about 1 to about 4 kp/cm2.
136. The dosage form of claim 124, wherein there is no subcoating between the compressed dosage form and the coating.
137. The method of claim 1, 14, or 24, wherein the flowable material is substantially solvent-free.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US09/966,497 US7122143B2 (en) | 2001-09-28 | 2001-09-28 | Methods for manufacturing dosage forms |
US09/966,497 | 2001-09-28 | ||
PCT/US2002/030650 WO2003028619A2 (en) | 2001-09-28 | 2002-09-26 | Systems, methods and apparatuses for manufacturing dosage forms |
Publications (2)
Publication Number | Publication Date |
---|---|
CA2461873A1 true CA2461873A1 (en) | 2003-04-10 |
CA2461873C CA2461873C (en) | 2012-10-30 |
Family
ID=25511500
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CA2461873A Expired - Fee Related CA2461873C (en) | 2001-09-28 | 2002-09-26 | Systems, methods and apparatuses for manufacturing dosage forms |
Country Status (10)
Country | Link |
---|---|
US (3) | US7122143B2 (en) |
EP (1) | EP1432378B1 (en) |
JP (1) | JP2005504589A (en) |
KR (1) | KR20040039459A (en) |
CN (1) | CN1635863A (en) |
AT (1) | ATE418953T1 (en) |
CA (1) | CA2461873C (en) |
DE (1) | DE60230649D1 (en) |
MX (1) | MXPA04002969A (en) |
WO (1) | WO2003028619A2 (en) |
Families Citing this family (83)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE10026698A1 (en) | 2000-05-30 | 2001-12-06 | Basf Ag | Self-emulsifying active ingredient formulation and use of this formulation |
ATE404179T1 (en) * | 2001-09-28 | 2008-08-15 | Mcneil Ppc Inc | DOSAGE FORMS WITH CORE AND OUTER SHELL |
US7122143B2 (en) | 2001-09-28 | 2006-10-17 | Mcneil-Ppc, Inc. | Methods for manufacturing dosage forms |
US7838026B2 (en) | 2001-09-28 | 2010-11-23 | Mcneil-Ppc, Inc. | Burst-release polymer composition and dosage forms comprising the same |
US7217381B2 (en) * | 2001-09-28 | 2007-05-15 | Mcneil-Ppc, Inc. | Systems, methods and apparatuses for manufacturing dosage forms |
US20040146559A1 (en) * | 2002-09-28 | 2004-07-29 | Sowden Harry S. | Dosage forms having an inner core and outer shell with different shapes |
US20040253312A1 (en) * | 2001-09-28 | 2004-12-16 | Sowden Harry S. | Immediate release dosage form comprising shell having openings therein |
US6837696B2 (en) * | 2001-09-28 | 2005-01-04 | Mcneil-Ppc, Inc. | Apparatus for manufacturing dosage forms |
US7807197B2 (en) * | 2002-09-28 | 2010-10-05 | Mcneil-Ppc, Inc. | Composite dosage forms having an inlaid portion |
US20060210633A1 (en) * | 2003-04-03 | 2006-09-21 | Sun Pharmaceutical Industries Limited | Programmed drug delivery system |
US8025899B2 (en) | 2003-08-28 | 2011-09-27 | Abbott Laboratories | Solid pharmaceutical dosage form |
US8377952B2 (en) | 2003-08-28 | 2013-02-19 | Abbott Laboratories | Solid pharmaceutical dosage formulation |
US20050074514A1 (en) * | 2003-10-02 | 2005-04-07 | Anderson Oliver B. | Zero cycle molding systems, methods and apparatuses for manufacturing dosage forms |
US8067029B2 (en) | 2004-01-13 | 2011-11-29 | Mcneil-Ppc, Inc. | Rapidly disintegrating gelatinous coated tablets |
US7879354B2 (en) * | 2004-01-13 | 2011-02-01 | Mcneil-Ppc, Inc. | Rapidly disintegrating gelatinous coated tablets |
US20050196448A1 (en) * | 2004-03-05 | 2005-09-08 | Hai Yong Huang | Polymeric compositions and dosage forms comprising the same |
US20050196447A1 (en) * | 2004-03-05 | 2005-09-08 | Huang Hai Y. | Polymeric compositions and dosage forms comprising the same |
US20050196446A1 (en) * | 2004-03-05 | 2005-09-08 | Huang Hai Y. | Polymeric compositions and dosage forms comprising the same |
US20050196442A1 (en) * | 2004-03-05 | 2005-09-08 | Huang Hai Y. | Polymeric compositions and dosage forms comprising the same |
FR2872718B1 (en) * | 2004-07-08 | 2006-10-20 | Sidel Sa Sa | PROCESS FOR PROCESSING A CONTAINER COMPRISING VACUUM PUMP PHASES AND MACHINE FOR CARRYING OUT SAID METHOD |
US20070281022A1 (en) * | 2004-10-27 | 2007-12-06 | Bunick Frank J | Dosage forms having a microreliefed surface and methods and apparatus for their production |
US20070190133A1 (en) * | 2004-10-27 | 2007-08-16 | Bunick Frank J | Dosage forms having a microreliefed surface and methods and apparatus for their production |
US20060087051A1 (en) * | 2004-10-27 | 2006-04-27 | Bunick Frank J | Dosage forms having a microreliefed surface and methods and apparatus for their production |
US20060088587A1 (en) * | 2004-10-27 | 2006-04-27 | Bunick Frank J | Dosage forms having a microreliefed surface and methods and apparatus for their production |
US20060088586A1 (en) * | 2004-10-27 | 2006-04-27 | Bunick Frank J | Dosage forms having a microreliefed surface and methods and apparatus for their production |
US20060088593A1 (en) * | 2004-10-27 | 2006-04-27 | Bunick Frank J | Dosage forms having a microreliefed surface and methods and apparatus for their production |
US8383159B2 (en) * | 2004-10-27 | 2013-02-26 | Mcneil-Ppc, Inc. | Dosage forms having a microreliefed surface and methods and apparatus for their production |
US20060093560A1 (en) * | 2004-10-29 | 2006-05-04 | Jen-Chi Chen | Immediate release film coating |
US7530804B2 (en) * | 2004-12-07 | 2009-05-12 | Mcneil-Ppc, Inc. | System and process for providing at least one opening in dosage forms |
US7404708B2 (en) * | 2004-12-07 | 2008-07-29 | Mcneil-Ppc, Inc. | System and process for providing at least one opening in dosage forms |
US8211078B2 (en) | 2005-02-17 | 2012-07-03 | The Procter And Gamble Company | Sanitary napkins capable of taking complex three-dimensional shape in use |
US9579238B2 (en) | 2005-02-17 | 2017-02-28 | The Procter & Gamble Company | Sanitary napkins capable of taking complex three-dimensional shape in use |
US8673352B2 (en) | 2005-04-15 | 2014-03-18 | Mcneil-Ppc, Inc. | Modified release dosage form |
US20060233882A1 (en) * | 2005-04-15 | 2006-10-19 | Sowden Harry S | Osmotic dosage form |
CN103259027A (en) | 2005-04-28 | 2013-08-21 | 普罗透斯数字保健公司 | Pharma-informatics system |
US8802183B2 (en) | 2005-04-28 | 2014-08-12 | Proteus Digital Health, Inc. | Communication system with enhanced partial power source and method of manufacturing same |
US20070048366A1 (en) * | 2005-08-26 | 2007-03-01 | Jen-Chi Chen | Gelatin-based coatings having improved durability |
US7485609B2 (en) * | 2005-09-29 | 2009-02-03 | Kimberly-Clark Worldwide, Inc. | Encapsulated liquid cleanser |
US20070224258A1 (en) * | 2006-03-22 | 2007-09-27 | Bunick Frank J | Dosage forms having a randomized coating |
KR20090009214A (en) * | 2006-03-28 | 2009-01-22 | 맥네일-피피씨, 인코포레이티드 | Non-homogenous dosage form coatings |
US20080035667A1 (en) * | 2006-06-07 | 2008-02-14 | Osg Norwich Pharmaceuticals, Inc. | Liquid delivery system |
US20080075766A1 (en) * | 2006-09-25 | 2008-03-27 | Shun-Por Li | Multi-core dosage form having transparent outer coating |
AU2007309281B2 (en) * | 2006-10-20 | 2013-10-31 | Johnson & Johnson Consumer Inc. | Acetaminophen / ibuprofen combinations |
BRPI0718428A2 (en) * | 2006-10-25 | 2013-11-12 | Mcneil Ppc Inc | IBUPROPHEN COMPOSITION |
US8357395B2 (en) * | 2007-12-21 | 2013-01-22 | Mcneil-Ppc, Inc. | Manufacture of tablet |
EP2364143A1 (en) * | 2008-10-31 | 2011-09-14 | McNeil-PPC, Inc. | Osmotic tablet with a compressed outer coating |
KR200453578Y1 (en) * | 2009-03-06 | 2011-05-17 | 박대호 | Pavement block for a blind person |
EP3906845A1 (en) | 2009-04-28 | 2021-11-10 | Otsuka Pharmaceutical Co., Ltd. | Highly reliable ingestible event markers |
TWI471127B (en) * | 2009-04-29 | 2015-02-01 | Intervet Int Bv | A process for preparing an orally disintegrating tablet for human use, an orally disintegrating tablet thus obtained and a package containing the orally disintegrating tablet |
UA109424C2 (en) * | 2009-12-02 | 2015-08-25 | PHARMACEUTICAL PRODUCT, PHARMACEUTICAL TABLE WITH ELECTRONIC MARKER AND METHOD OF MANUFACTURING PHARMACEUTICAL TABLETS | |
SG184494A1 (en) | 2010-04-07 | 2012-11-29 | Proteus Biomedical Inc | Miniature ingestible device |
EP2409676A1 (en) * | 2010-07-06 | 2012-01-25 | Intervet International B.V. | Method for dosing a fluid formulation containing a medicinal substance |
JP2014504902A (en) | 2010-11-22 | 2014-02-27 | プロテウス デジタル ヘルス, インコーポレイテッド | Ingestible device with medicinal product |
JP5673287B2 (en) * | 2011-03-29 | 2015-02-18 | 東洋製罐株式会社 | Compression molding system |
WO2015112603A1 (en) | 2014-01-21 | 2015-07-30 | Proteus Digital Health, Inc. | Masticable ingestible product and communication system therefor |
US9756874B2 (en) | 2011-07-11 | 2017-09-12 | Proteus Digital Health, Inc. | Masticable ingestible product and communication system therefor |
US9445971B2 (en) * | 2012-05-01 | 2016-09-20 | Johnson & Johnson Consumer Inc. | Method of manufacturing solid dosage form |
DE102012010263A1 (en) * | 2012-05-25 | 2013-11-28 | Bleistahl-Produktions Gmbh & Co Kg | Rotary transfer molding machine |
ES2831082T3 (en) | 2012-08-21 | 2021-06-07 | Vertera Inc | Method for forming porous polymeric particles |
WO2014074797A1 (en) * | 2012-11-09 | 2014-05-15 | Civitas Therapeutics, Inc. | Ultra low density pulmonary powders |
US11149123B2 (en) | 2013-01-29 | 2021-10-19 | Otsuka Pharmaceutical Co., Ltd. | Highly-swellable polymeric films and compositions comprising the same |
US10175376B2 (en) | 2013-03-15 | 2019-01-08 | Proteus Digital Health, Inc. | Metal detector apparatus, system, and method |
US9796576B2 (en) | 2013-08-30 | 2017-10-24 | Proteus Digital Health, Inc. | Container with electronically controlled interlock |
US10084880B2 (en) | 2013-11-04 | 2018-09-25 | Proteus Digital Health, Inc. | Social media networking based on physiologic information |
CA2933867A1 (en) * | 2013-12-16 | 2015-06-25 | Massachusetts Institute Of Technology | Micromolded or 3-d printed pulsatile release vaccine formulations |
US9504550B2 (en) | 2014-06-26 | 2016-11-29 | Vertera, Inc. | Porous devices and processes for producing same |
US9498922B2 (en) | 2014-06-26 | 2016-11-22 | Vertera, Inc. | Apparatus and process for producing porous devices |
US9517593B2 (en) | 2014-06-26 | 2016-12-13 | Vertera, Inc. | Apparatus and process for producing porous devices |
US9085665B1 (en) | 2014-12-31 | 2015-07-21 | Vertera, Inc. | Method for producing porous material |
MX2017012878A (en) | 2015-04-07 | 2018-08-15 | Church & Dwight Co Inc | Multicomponent gummy compositions with hard core. |
USD815281S1 (en) | 2015-06-23 | 2018-04-10 | Vertera, Inc. | Cervical interbody fusion device |
US11051543B2 (en) | 2015-07-21 | 2021-07-06 | Otsuka Pharmaceutical Co. Ltd. | Alginate on adhesive bilayer laminate film |
USD809576S1 (en) * | 2016-07-08 | 2018-02-06 | Ackley Machine Corporation | Carrier link for longitudinally compressed tablet |
KR102215238B1 (en) | 2016-07-22 | 2021-02-22 | 프로테우스 디지털 헬스, 인코포레이티드 | Electromagnetic sensing and detection of ingestible event markers |
WO2018081337A1 (en) | 2016-10-26 | 2018-05-03 | Proteus Digital Health, Inc. | Methods for manufacturing capsules with ingestible event markers |
DE102016123279B4 (en) * | 2016-12-01 | 2019-02-21 | Fette Compacting Gmbh | Method and system for feeding a lubricant or release agent to press tools of a tablet press |
GR1009361B (en) | 2017-05-11 | 2018-09-17 | Κωνσταντινος Ηλια Θεοδοσοπουλος | A system for the production of tablets, granules and capsules via three-dimensional printing |
CN111065475B (en) * | 2017-08-21 | 2022-03-15 | 住友电工烧结合金株式会社 | Shaping device and method for producing sintered body |
DE102017130885B4 (en) * | 2017-12-21 | 2020-01-23 | Fette Compacting Gmbh | Method for regulating the rotor speed of a rotor of a rotary tablet press and rotary tablet press |
CN112272557B (en) * | 2018-06-11 | 2023-11-03 | 康蒂纽斯制药公司 | System for moulding and coating pharmaceutical tablets |
KR102155872B1 (en) * | 2020-05-08 | 2020-09-14 | 주식회사 동해종합기술공사 | carbonation depth measuring device |
CN112336625B (en) * | 2020-10-05 | 2021-12-14 | 山东赫尔希胶囊有限公司 | A shell forming device for capsule production |
US20230001663A1 (en) * | 2021-07-02 | 2023-01-05 | Industrial Pharmaceutical Resources, Inc. | Rotary tablet press with multiple row turret |
Family Cites Families (343)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US545832A (en) | 1895-09-03 | Machine for compressing and molding popcorn | ||
US599865A (en) | 1898-03-01 | Emanuel l | ||
US3371136A (en) | 1968-02-27 | United States Borax Chem | Detergent tablet forming machine | |
US582438A (en) | 1897-05-11 | John scheidler | ||
US596768A (en) * | 1898-01-04 | Automatically-operated stringed musical instrument | ||
US449983A (en) | 1891-04-07 | Nut-lock | ||
US1036647A (en) | 1911-06-19 | 1912-08-27 | St Louis Briquette Machine Company | Briquet-machine. |
US1437816A (en) | 1922-07-26 | 1922-12-05 | Howard S Paine | Process for preparing fondant or chocolate soft cream centers |
US1505827A (en) * | 1923-04-25 | 1924-08-19 | Villasenor Eduardo | Tablet-making machine |
US1900012A (en) | 1925-09-04 | 1933-03-07 | Western Cartridge Co | Process of and apparatus for making wads |
US2026940A (en) * | 1934-12-13 | 1936-01-07 | Harbison Walker Refractories | Shaping refractory articles |
US2361348A (en) * | 1939-10-12 | 1944-10-24 | Spalding A G & Bros Inc | Process and apparatus for making balls |
US2307371A (en) | 1941-08-13 | 1943-01-05 | Ray O Vac Co | Molding process |
US2415997A (en) | 1946-01-12 | 1947-02-18 | John W Eldred | Article handling apparatus |
US2823789A (en) | 1952-05-06 | 1958-02-18 | Gilman Engineering & Mfg Corp | Parts feeder ribbon |
GB759081A (en) | 1954-04-15 | 1956-10-10 | John Holroyd And Company Ltd | Improvements relating to machines for the production of coated tablets and the like |
US2849965A (en) | 1954-04-15 | 1958-09-02 | John Holroyd & Company Ltd | Machines for use in the production of coated tablets and the like |
US2966431A (en) | 1956-03-24 | 1960-12-27 | Basf Ag | Separation of filter material from carbon black |
US2946298A (en) | 1957-11-13 | 1960-07-26 | Arthur Colton Company | Compression coating tablet press |
US2931276A (en) | 1958-02-10 | 1960-04-05 | Jagenberg Werke Ag | Methods of and means for producing, processing, and for treating articles |
GB866681A (en) | 1958-05-22 | 1961-04-26 | May & Baker Ltd | N-substituted piperidines |
GB888038A (en) | 1959-12-16 | 1962-01-24 | William Warren Triggs C B E | Medicinal tablet |
GB936386A (en) | 1959-01-16 | 1963-09-11 | Wellcome Found | Pellets for supplying biologically active substances to ruminants |
US2963993A (en) | 1959-01-20 | 1960-12-13 | John Holroyd & Company Ltd | Machines for making coated tablets by compression |
US3096248A (en) | 1959-04-06 | 1963-07-02 | Rexall Drug & Chemical Company | Method of making an encapsulated tablet |
US3029752A (en) | 1959-07-20 | 1962-04-17 | Stokes F J Corp | Tablet making machine |
GB972128A (en) * | 1960-01-21 | 1964-10-07 | Wellcome Found | Pellets for supplying biologically active substances to ruminants and the manufacture of such pellets |
GB990784A (en) | 1960-05-23 | 1965-05-05 | Dunlop Rubber Co | Improvements in or relating to balls |
GB994742A (en) | 1960-09-09 | 1965-06-10 | Wellcome Found | Pharmaceutical tablets containing anthelmintics, and the manufacture thereof |
US3108046A (en) | 1960-11-25 | 1963-10-22 | Smith Kline French Lab | Method of preparing high dosage sustained release tablet and product of this method |
NL125920C (en) | 1960-12-28 | |||
US3430535A (en) | 1961-08-25 | 1969-03-04 | Independent Lock Co | Key cutter |
BE636865A (en) | 1962-08-31 | |||
US3185626A (en) | 1963-03-06 | 1965-05-25 | Sterling Drug Inc | Tablet coating method |
US3300063A (en) | 1965-01-25 | 1967-01-24 | Mayer & Co Inc O | Vacuum gripping apparatus |
FR1603314A (en) | 1965-02-23 | 1971-04-05 | Pharmaceutical tablets - having a core and a matrix material | |
US3328840A (en) * | 1965-04-23 | 1967-07-04 | Pentronix Inc | Powder compacting press |
US3279360A (en) | 1965-09-13 | 1966-10-18 | Miehle Goss Dexter Inc | Machine for printing on cylindrical articles |
US3330400A (en) | 1966-03-08 | 1967-07-11 | Miehle Goss Dexter Inc | Mechanism for transferring cylindrical articles |
GB1212535A (en) | 1966-10-12 | 1970-11-18 | Shionogi & Co | Method and apparatus for producing molded article |
US3458968A (en) | 1966-11-16 | 1969-08-05 | Lester Gregory Jr | Dispensing and feed mechanism |
GB1144915A (en) | 1966-11-24 | 1969-03-12 | Armour Pharma | Improvements in or relating to pastille formulations |
US3656518A (en) | 1967-03-27 | 1972-04-18 | Perry Ind Inc | Method and apparatus for measuring and dispensing predetermined equal amounts of powdered material |
US3430532A (en) | 1967-07-13 | 1969-03-04 | Usm Corp | Means for making pellets,particularly explosive pellets |
US3518866A (en) | 1967-12-12 | 1970-07-07 | Bliss Co | Feed or discharge mechanism for a forming press |
US3563170A (en) | 1968-04-16 | 1971-02-16 | Reynolds Metals Co | Machine for marking the exterior cylindrical surfaces of cans in a continous nonidexing manner |
US3605479A (en) | 1968-05-08 | 1971-09-20 | Textron Inc | Forming press |
US3584114A (en) | 1968-05-22 | 1971-06-08 | Hoffmann La Roche | Free-flowing powders |
US3567043A (en) | 1968-08-05 | 1971-03-02 | Sun Chemical Corp | Transfer assembly for use with container printing machines |
US3627583A (en) | 1969-04-29 | 1971-12-14 | Sucrest Corp | Direct compression vehicles |
US3640654A (en) * | 1970-06-25 | 1972-02-08 | Wolverine Pentronix | Die and punch assembly for compacting powder and method of assembly |
US3832252A (en) | 1970-09-29 | 1974-08-27 | T Higuchi | Method of making a drug-delivery device |
CH569482A5 (en) | 1970-12-23 | 1975-11-28 | Boehringer Sohn Ingelheim | |
US3811552A (en) | 1971-01-11 | 1974-05-21 | Lilly Co Eli | Capsule inspection apparatus and method |
US3726622A (en) | 1971-08-20 | 1973-04-10 | Wolverine Pentronix | Compacting apparatus |
DE2157465C3 (en) | 1971-11-19 | 1975-04-24 | Werner & Pfleiderer, 7000 Stuttgart | Filling device for a hydraulic block press |
US3975888A (en) | 1972-04-26 | 1976-08-24 | R. A. Jones & Company, Inc. | Method and apparatus for forming, filling and sealing packages |
US3851751A (en) | 1972-04-26 | 1974-12-03 | Jones & Co Inc R A | Method and apparatus for forming, filling and sealing packages |
US3912441A (en) | 1972-12-13 | 1975-10-14 | Yasuo Shimada | Compressing roll in rotary power compression molding machine |
DE2309202A1 (en) | 1973-02-21 | 1974-08-29 | Schering Ag | MEDICINAL FORMS WITH MICRO-ENCAPSULATED MEDICINAL ACTIVE |
US3884143A (en) | 1973-09-04 | 1975-05-20 | Hartnett Co R W | Conveyor link for tablet printing apparatus |
US3891375A (en) | 1974-01-21 | 1975-06-24 | Vector Corp | Tablet press |
GB1497044A (en) | 1974-03-07 | 1978-01-05 | Prodotti Antibiotici Spa | Salts of phenyl-alkanoic acids |
US3988403A (en) | 1974-07-09 | 1976-10-26 | Union Carbide Corporation | Process for producing molded structural foam article having a surface that reproducibly and faithfully replicates the surface of the mold |
US4139589A (en) * | 1975-02-26 | 1979-02-13 | Monique Beringer | Process for the manufacture of a multi-zone tablet and tablet manufactured by this process |
US3999922A (en) * | 1975-04-16 | 1976-12-28 | Yasuo Shimada | Rotary tableting machine |
US4230693A (en) * | 1975-04-21 | 1980-10-28 | Armour-Dial, Inc. | Antacid tablets and processes for their preparation |
FR2312247A1 (en) | 1975-05-30 | 1976-12-24 | Parcor | THIENO-PYRIDINE DERIVATIVES, THEIR PREPARATION PROCESS AND THEIR APPLICATIONS |
US4061452A (en) * | 1975-10-06 | 1977-12-06 | Wolverine Aluminum Corporation | Apparatus for producing spherical articles |
US4061453A (en) * | 1975-10-06 | 1977-12-06 | Wolverine Aluminum Corporation | Tooling for a powder compacting press |
US4097606A (en) | 1975-10-08 | 1978-06-27 | Bristol-Myers Company | APAP Tablet containing an alkali metal carboxymethylated starch and processes for manufacturing same |
SE414386B (en) | 1976-03-10 | 1980-07-28 | Aco Laekemedel Ab | VIEW TO PREPARE AND AT THE SAME PACKAGE PHARMACEUTICAL DOSAGE UNITS |
JPS52119474A (en) * | 1976-03-31 | 1977-10-06 | Hata Iron Works | Rotary powder compression molder |
GB1548022A (en) | 1976-10-06 | 1979-07-04 | Wyeth John & Brother Ltd | Pharmaceutial dosage forms |
DE2752971C2 (en) * | 1977-11-28 | 1982-08-19 | Lev Nikolaevič Moskva Koškin | Injection molding machine for the production of injection molded parts from thermoplastic materials |
GB2030042A (en) * | 1978-09-21 | 1980-04-02 | Beecham Group Ltd | Antacid fondant |
US4173626A (en) | 1978-12-11 | 1979-11-06 | Merck & Co., Inc. | Sustained release indomethacin |
US4271142A (en) | 1979-06-18 | 1981-06-02 | Life Savers, Inc. | Portable liquid antacids |
JPS5827162B2 (en) | 1979-08-24 | 1983-06-08 | 株式会社ヤクルト本社 | Constant speed transport mechanism |
NL7906689A (en) | 1979-09-06 | 1981-03-10 | Dawsonville Corp Nv | TATTOO. |
US4271206A (en) * | 1979-10-26 | 1981-06-02 | General Foods Corporation | Gasified candy having a predetermined shape |
US4273793A (en) * | 1979-10-26 | 1981-06-16 | General Foods Corporation | Apparatus and process for the preparation of gasified confectionaries by pressurized injection molding |
US4543370A (en) | 1979-11-29 | 1985-09-24 | Colorcon, Inc. | Dry edible film coating composition, method and coating form |
US4473526A (en) | 1980-01-23 | 1984-09-25 | Eugen Buhler | Method of manufacturing dry-pressed molded articles |
US4292017A (en) | 1980-07-09 | 1981-09-29 | Doepel Wallace A | Apparatus for compressing tablets |
US4362757A (en) * | 1980-10-22 | 1982-12-07 | Amstar Corporation | Crystallized, readily water dispersible sugar product containing heat sensitive, acidic or high invert sugar substances |
US4683256A (en) | 1980-11-06 | 1987-07-28 | Colorcon, Inc. | Dry edible film coating composition, method and coating form |
US4327076A (en) | 1980-11-17 | 1982-04-27 | Life Savers, Inc. | Compressed chewable antacid tablet and method for forming same |
US5002970A (en) * | 1981-07-31 | 1991-03-26 | Eby Iii George A | Flavor masked ionizable zinc compositions for oral absorption |
US4372942A (en) * | 1981-08-13 | 1983-02-08 | Beecham Inc. | Candy base and liquid center hard candy made therefrom |
DE3144678A1 (en) | 1981-11-10 | 1983-05-19 | Eugen Dipl.-Ing. 8871 Burtenbach Bühler | METHOD AND DEVICE FOR THE PRODUCTION OF MOLDINGS FROM A GIANT CAPABILITY |
JPS58152813A (en) | 1982-03-08 | 1983-09-10 | Sumitomo Chem Co Ltd | Tablet having clear carved seal and its preparation |
US4449983A (en) | 1982-03-22 | 1984-05-22 | Alza Corporation | Simultaneous delivery of two drugs from unit delivery device |
US4576604A (en) | 1983-03-04 | 1986-03-18 | Alza Corporation | Osmotic system with instant drug availability |
US4882167A (en) | 1983-05-31 | 1989-11-21 | Jang Choong Gook | Dry direct compression compositions for controlled release dosage forms |
US4533345A (en) | 1983-06-14 | 1985-08-06 | Fertility & Genetics Associates | Uterine catheter |
US4749575A (en) * | 1983-10-03 | 1988-06-07 | Bio-Dar Ltd. | Microencapsulated medicament in sweet matrix |
NL194820C (en) | 1983-11-02 | 2003-04-03 | Alza Corp | Preparation for the release of a heat-reacting composition. |
US4781714A (en) | 1983-11-02 | 1988-11-01 | Alza Corporation | Dispenser for delivering thermo-responsive composition |
AU591171B2 (en) | 1983-11-02 | 1989-11-30 | Alza Corporation | Dispenser for delivering thermo-responsive composition |
DE3404108A1 (en) | 1984-02-07 | 1985-08-14 | Kilian & Co GmbH, 5000 Köln | TABLET PRESS |
US4518335A (en) | 1984-03-14 | 1985-05-21 | Allied Corporation | Dilatant mold and dilatant molding apparatus |
JPS60217106A (en) | 1984-04-12 | 1985-10-30 | 高橋 信之 | Inorganic-powder freezing molding method |
US4661521A (en) | 1984-04-30 | 1987-04-28 | Mallinckrodt, Inc. | Direct tableting acetaminophen compositions |
US4528335A (en) | 1984-05-18 | 1985-07-09 | Phillips Petroleum Company | Polymer blends |
US4643894A (en) | 1984-07-24 | 1987-02-17 | Colorcon, Inc. | Maltodextrin coating |
US4828841A (en) | 1984-07-24 | 1989-05-09 | Colorcon, Inc. | Maltodextrin coating |
US4894234A (en) | 1984-10-05 | 1990-01-16 | Sharma Shri C | Novel drug delivery system for antiarrhythmics |
US4684534A (en) | 1985-02-19 | 1987-08-04 | Dynagram Corporation Of America | Quick-liquifying, chewable tablet |
US4587330A (en) * | 1985-02-22 | 1986-05-06 | Atlantic Richfield Company | Purification of polymer solutions |
CA1234717A (en) | 1985-06-28 | 1988-04-05 | Leslie F. Knebl | Moist chewing gum composition |
GB8517073D0 (en) | 1985-07-05 | 1985-08-14 | Hepworth Iron Co Ltd | Pipe pipe couplings &c |
DK8603837A (en) | 1985-08-13 | 1987-02-14 | ||
US4665116A (en) | 1985-08-28 | 1987-05-12 | Turtle Wax, Inc. | Clear cleaner/polish composition |
US5188840A (en) | 1985-09-26 | 1993-02-23 | Chugai Seiyaku Kabushiki Kaisha | Slow-release pharmaceutical agent |
US4898733A (en) | 1985-11-04 | 1990-02-06 | International Minerals & Chemical Corp. | Layered, compression molded device for the sustained release of a beneficial agent |
US4853249A (en) | 1985-11-15 | 1989-08-01 | Taisho Pharmaceutical Co., Ltd. | Method of preparing sustained-release pharmaceutical/preparation |
US5229164A (en) | 1985-12-19 | 1993-07-20 | Capsoid Pharma Gmbh | Process for producing individually dosed administration forms |
JPS62230600A (en) | 1986-03-31 | 1987-10-09 | 東洋ゴム工業株式会社 | Forklift with expansible fork |
DE3610878A1 (en) | 1986-04-01 | 1987-10-08 | Boehringer Ingelheim Kg | PELLET SHAPES |
US4873231A (en) | 1986-04-08 | 1989-10-10 | Smith Walton J | Decreasing the toxicity of an ibuprofen salt |
US4857330A (en) | 1986-04-17 | 1989-08-15 | Alza Corporation | Chlorpheniramine therapy |
US4802924A (en) | 1986-06-19 | 1989-02-07 | Colorcon, Inc. | Coatings based on polydextrose for aqueous film coating of pharmaceutical food and confectionary products |
IE58401B1 (en) | 1986-06-20 | 1993-09-08 | Elan Corp Plc | Controlled absorption pharmaceutical composition |
US4757090A (en) | 1986-07-14 | 1988-07-12 | Mallinckrodt, Inc. | Direct tableting acetaminophen compositions |
US4762719A (en) * | 1986-08-07 | 1988-08-09 | Mark Forester | Powder filled cough product |
CA1290526C (en) | 1986-11-07 | 1991-10-15 | Marianne Wieser | Mold and die operation |
DE3640574A1 (en) | 1986-11-27 | 1988-06-09 | Katjes Fassin Gmbh & Co Kg | METHOD FOR PRODUCING AN EDIBLE PRALINE-SHAPED PRODUCT AND DEVICE FOR IMPLEMENTING THE METHOD |
US4828845A (en) | 1986-12-16 | 1989-05-09 | Warner-Lambert Company | Xylitol coated comestible and method of preparation |
IT1201136B (en) | 1987-01-13 | 1989-01-27 | Resa Farma | TABLET FOR PHARMACEUTICAL USE SUITABLE FOR THE RELEASE OF SUBSTANCES OF ACTIVE SUBSTANCES |
US4801461A (en) | 1987-01-28 | 1989-01-31 | Alza Corporation | Pseudoephedrine dosage form |
US4820524A (en) | 1987-02-20 | 1989-04-11 | Mcneilab, Inc. | Gelatin coated caplets and process for making same |
US5234099A (en) | 1987-02-20 | 1993-08-10 | Mcneil-Ppc, Inc. | Coated medicaments and apparatus and methods for making same |
US4808413A (en) | 1987-04-28 | 1989-02-28 | E. R. Squibb & Sons, Inc. | Pharmaceutical compositions in the form of beadlets and method |
US5100275A (en) * | 1987-05-20 | 1992-03-31 | Schirrmacher Wendell E | Quick locking fasteners |
US4792448A (en) | 1987-06-11 | 1988-12-20 | Pfizer Inc. | Generic zero order controlled drug delivery system |
US4813818A (en) | 1987-08-25 | 1989-03-21 | Michael Sanzone | Apparatus and method for feeding powdered materials |
US4996061A (en) | 1987-10-07 | 1991-02-26 | Merrell Dow Pharmaceuticals Inc. | Pharmaceutical composition for piperidinoalkanol-decongestant combination |
US4851226A (en) | 1987-11-16 | 1989-07-25 | Mcneil Consumer Products Company | Chewable medicament tablet containing means for taste masking |
DE3739551A1 (en) | 1987-11-21 | 1989-06-01 | Focke & Co | DEVICE FOR TRANSPORTING CIGARETTE PACKS IN CONNECTION WITH A PACKING MACHINE |
FR2623976B1 (en) | 1987-12-08 | 1994-02-25 | So Ge Val | TABLET FOR DOMESTIC ANIMALS |
IT1221567B (en) | 1987-12-30 | 1990-07-12 | Ima Spa | COMPRESSING MACHINE FOR THE PRODUCTION OF TABLETS |
US4894236A (en) | 1988-01-12 | 1990-01-16 | Choong-Gook Jang | Direct compression tablet binders for acetaminophen |
US5030447A (en) | 1988-03-31 | 1991-07-09 | E. R. Squibb & Sons, Inc. | Pharmaceutical compositions having good stability |
US4929446A (en) * | 1988-04-19 | 1990-05-29 | American Cyanamid Company | Unit dosage form |
US5088915A (en) | 1988-06-08 | 1992-02-18 | Korsch Ohg Maschinenfabrik | Coated-core press |
DE3822095A1 (en) | 1988-06-30 | 1990-01-04 | Klinge Co Chem Pharm Fab | NEW MEDICAMENT FORMULATION AND METHOD FOR THE PRODUCTION THEREOF |
DE3830353A1 (en) | 1988-09-07 | 1990-03-15 | Basf Ag | METHOD FOR THE CONTINUOUS PRODUCTION OF SOLID PHARMACEUTICAL FORMS |
JPH0816051B2 (en) | 1988-12-07 | 1996-02-21 | エスエス製薬株式会社 | Sustained release suppositories |
US4906478A (en) | 1988-12-12 | 1990-03-06 | Valentine Enterprises, Inc. | Simethicone/calcium silicate composition |
US4984240A (en) | 1988-12-22 | 1991-01-08 | Codex Corporation | Distributed switching architecture for communication module redundancy |
US5006297A (en) | 1989-02-22 | 1991-04-09 | Acushnet Company | Method of molding polyurethane covered golf balls |
US4956182A (en) | 1989-03-16 | 1990-09-11 | Bristol-Myers Company | Direct compression cholestyramine tablet and solvent-free coating therefor |
NZ233403A (en) | 1989-04-28 | 1992-09-25 | Mcneil Ppc Inc | Simulated capsule-like medicament |
US4990535A (en) | 1989-05-03 | 1991-02-05 | Schering Corporation | Pharmaceutical composition comprising loratadine, ibuprofen and pseudoephedrine |
US4992277A (en) | 1989-08-25 | 1991-02-12 | Schering Corporation | Immediate release diltiazem formulation |
EP0419410A3 (en) | 1989-09-19 | 1991-08-14 | Ciba-Geigy Ag | Alkanophenones |
US5362508A (en) | 1989-09-20 | 1994-11-08 | Nabisco, Inc. | Process for preparing soft centers in food products |
US5146730A (en) | 1989-09-20 | 1992-09-15 | Banner Gelatin Products Corp. | Film-enrobed unitary-core medicament and the like |
DK469989D0 (en) * | 1989-09-22 | 1989-09-22 | Bukh Meditec | PHARMACEUTICAL PREPARATION |
US5178878A (en) | 1989-10-02 | 1993-01-12 | Cima Labs, Inc. | Effervescent dosage form with microparticles |
US5223264A (en) | 1989-10-02 | 1993-06-29 | Cima Labs, Inc. | Pediatric effervescent dosage form |
US5275822A (en) | 1989-10-19 | 1994-01-04 | Valentine Enterprises, Inc. | Defoaming composition |
JPH03139496A (en) * | 1989-10-25 | 1991-06-13 | Sanshin Ind Co Ltd | Ship propulsion machinery |
US5169645A (en) | 1989-10-31 | 1992-12-08 | Duquesne University Of The Holy Ghost | Directly compressible granules having improved flow properties |
US5223266A (en) * | 1990-01-24 | 1993-06-29 | Alza Corporation | Long-term delivery device with early startup |
DE4012114A1 (en) | 1990-04-14 | 1991-10-17 | Hauni Werke Koerber & Co Kg | DEVICE FOR CONVERTING ROD-SHAPED ARTICLES OF TOBACCO-PROCESSING INDUSTRY |
US4980169A (en) * | 1990-05-03 | 1990-12-25 | Warner-Lambert Company | Flavor enhancing and increasing efficacy of cough drops |
US4983394A (en) | 1990-05-03 | 1991-01-08 | Warner-Lambert Company | Flavor enhancing and medicinal taste masking agent |
US5089270A (en) | 1990-05-15 | 1992-02-18 | L. Perrigo Company | Capsule-shaped tablet |
US5213738A (en) | 1990-05-15 | 1993-05-25 | L. Perrigo Company | Method for making a capsule-shaped tablet |
US5075114A (en) * | 1990-05-23 | 1991-12-24 | Mcneil-Ppc, Inc. | Taste masking and sustained release coatings for pharmaceuticals |
US5464631A (en) * | 1990-06-27 | 1995-11-07 | Warner-Lambert Company | Encapsulated dosage forms |
DE4025487A1 (en) | 1990-08-08 | 1992-02-13 | Korsch Maschfab | Filling device for mould table of machine for forming tablets - in which powder is delivered by cams on surface of belt moving around two wheels in closed casing having controlled powder inlet flow rate |
US5133892A (en) | 1990-10-17 | 1992-07-28 | Lever Brothers Company, Division Of Conopco, Inc. | Machine dishwashing detergent tablets |
US5228916A (en) | 1990-11-05 | 1993-07-20 | Mcneil-Ppc, Inc. | Apparatus for creating a gelatin coating |
US5538125A (en) | 1990-11-05 | 1996-07-23 | Mcneil-Ppc, Inc. | Indexing and feeding systems for apparatus for gelatin coating tablets |
US5436026A (en) | 1990-11-05 | 1995-07-25 | Mcneil-Ppc, Inc. | Discharge and transfer system for apparatus for gelatin coating tablets |
US5503673A (en) | 1990-11-05 | 1996-04-02 | Mcneil-Ppc, Inc | Apparatus for dip coating product |
US5177080A (en) | 1990-12-14 | 1993-01-05 | Bayer Aktiengesellschaft | Substituted pyridyl-dihydroxy-heptenoic acid and its salts |
US5098715A (en) | 1990-12-20 | 1992-03-24 | Burroughs Wellcome Co. | Flavored film-coated tablet |
US5782337A (en) | 1991-01-15 | 1998-07-21 | Raychem Corporation | Conveyor belt system and heater utilizing said system |
IT1245763B (en) | 1991-02-11 | 1994-10-14 | Gd Spa | DEVICE FOR THE TRANSFER OF CIGARETTES OF CIGARETTE FROM A DOUBLE WHEEL PACKAGING MACHINE TO A FILTER FEEDING MACHINE. |
US5378475A (en) | 1991-02-21 | 1995-01-03 | University Of Kentucky Research Foundation | Sustained release drug delivery devices |
NZ241613A (en) * | 1991-02-27 | 1993-06-25 | Janssen Pharmaceutica Nv | Highlighting intagliations in tablets |
CA2061520C (en) | 1991-03-27 | 2003-04-22 | Lawrence J. Daher | Delivery system for enhanced onset and increased potency |
US5158728A (en) | 1991-04-12 | 1992-10-27 | Elizabeth-Hata International, Inc. | Multi-layer medicinal tablet forming machine and method for using the same |
US5286497A (en) | 1991-05-20 | 1994-02-15 | Carderm Capital L.P. | Diltiazem formulation |
CA2068402C (en) * | 1991-06-14 | 1998-09-22 | Michael R. Hoy | Taste mask coatings for preparation of chewable pharmaceutical tablets |
US5190927A (en) | 1991-07-09 | 1993-03-02 | Merck & Co., Inc. | High-glyceryl, low-acetyl gellan gum for non-brittle gels |
US5464632C1 (en) | 1991-07-22 | 2001-02-20 | Prographarm Lab | Rapidly disintegratable multiparticular tablet |
US5326570A (en) | 1991-07-23 | 1994-07-05 | Pharmavene, Inc. | Advanced drug delivery system and method of treating psychiatric, neurological and other disorders with carbamazepine |
US5200191A (en) * | 1991-09-11 | 1993-04-06 | Banner Gelatin Products Corp. | Softgel manufacturing process |
US5200195A (en) | 1991-12-06 | 1993-04-06 | Alza Corporation | Process for improving dosage form delivery kinetics |
DK171536B1 (en) | 1991-12-06 | 1996-12-23 | Rasmussen Kann Ind As | Window with frame of extruded profile items |
US5274162A (en) | 1991-12-13 | 1993-12-28 | Arnold Glazier | Antineoplastic drugs with bipolar toxification/detoxification functionalities |
GB2284760B (en) | 1993-11-23 | 1998-06-24 | Euro Celtique Sa | A method of preparing pharmaceutical compositions by melt pelletisation |
KR940703886A (en) | 1992-01-17 | 1994-12-12 | 토머스 디. 뵈닝 | Film Coatings and Film Coating Compositions Based on Cellulosic Polymers and Lactose |
US5427614A (en) | 1992-02-14 | 1995-06-27 | Warner-Lambert Company | Starch based formulations |
US5421447A (en) | 1992-04-07 | 1995-06-06 | Omega Design Corp. | High rate transfer wheel for orienting unscrambled containers |
US5656296A (en) | 1992-04-29 | 1997-08-12 | Warner-Lambert Company | Dual control sustained release drug delivery systems and methods for preparing same |
EP0572731A1 (en) | 1992-06-01 | 1993-12-08 | The Procter & Gamble Company | Chewable preparation containing a decongestant |
DE4218122C1 (en) | 1992-06-02 | 1994-01-20 | Fette Wilhelm Gmbh | Process for pressing two-layer tablets in a double rotary press and device for carrying out the process |
WO1993024109A1 (en) | 1992-06-04 | 1993-12-09 | Smithkline Beecham Corporation | Palatable pharmaceutical compositions |
JPH0617096A (en) | 1992-07-01 | 1994-01-25 | Asahi Glass Co Ltd | Solvent mixture composition |
US5317849A (en) | 1992-08-07 | 1994-06-07 | Sauter Manufacturing Corporation | Encapsulation equipment and method |
IT1255522B (en) | 1992-09-24 | 1995-11-09 | Ubaldo Conte | COMPRESSED FOR THERAPEUTIC USE SUITABLE FOR SELLING ONE OR MORE ACTIVE SUBSTANCES WITH DIFFERENT SPEEDS |
JPH07507564A (en) | 1992-09-30 | 1995-08-24 | ファイザー・インク. | Articles containing a core and a coating of variable thickness |
JP3380594B2 (en) | 1992-10-14 | 2003-02-24 | エーザイ株式会社 | Chemical solution pump and liquid solution filling device using the same |
DE69332801T2 (en) | 1992-11-30 | 2004-01-29 | Kv Pharm Co | TASTE-MASKED PHARMACEUTICAL SUBSTANCES |
DE4243010C1 (en) | 1992-12-19 | 1994-05-26 | Kronseder Maschf Krones | Packing machine |
TW272942B (en) | 1993-02-10 | 1996-03-21 | Takeda Pharm Industry Co Ltd | |
US5391378A (en) * | 1993-02-22 | 1995-02-21 | Elizabeth-Hata International, Inc. | Two-part medicinal tablet and method of manufacture |
JP2524955B2 (en) | 1993-04-22 | 1996-08-14 | トーワ株式会社 | Method and apparatus for resin sealing molding of electronic parts |
DE69425453T2 (en) * | 1993-04-23 | 2001-04-12 | Novartis Ag | Drug delivery device with controlled release |
US5342626A (en) | 1993-04-27 | 1994-08-30 | Merck & Co., Inc. | Composition and process for gelatin-free soft capsules |
US5415868A (en) | 1993-06-09 | 1995-05-16 | L. Perrigo Company | Caplets with gelatin cover and process for making same |
IT1264855B1 (en) | 1993-06-21 | 1996-10-17 | Zambon Spa | PHARMACEUTICAL COMPOSITIONS CONTAINING S (+) - 2- (4-ISOBUTYLPHENYL) PROPIONIC ACID SALTS WITH BASIC AMINO ACIDS |
IT1264696B1 (en) | 1993-07-09 | 1996-10-04 | Applied Pharma Res | PHARMACEUTICAL FORMS INTENDED FOR ORAL ADMINISTRATION ABLE TO RELEASE ACTIVE SUBSTANCES AT A CONTROLLED AND DIFFERENTIATED SPEED |
ZA944949B (en) | 1993-07-12 | 1995-04-05 | Smithkline Beecham Corp | Matrix-entrapped beadlet preparation |
US5773025A (en) | 1993-09-09 | 1998-06-30 | Edward Mendell Co., Inc. | Sustained release heterodisperse hydrogel systems--amorphous drugs |
US5622719A (en) * | 1993-09-10 | 1997-04-22 | Fuisz Technologies Ltd. | Process and apparatus for making rapidly dissolving dosage units and product therefrom |
US5648033A (en) | 1993-09-10 | 1997-07-15 | Fuisz Technologies Ltd. | Method and apparatus for retaining a formed compression dosage unit within a die cavity |
US5518551A (en) | 1993-09-10 | 1996-05-21 | Fuisz Technologies Ltd. | Spheroidal crystal sugar and method of making |
US5500227A (en) | 1993-11-23 | 1996-03-19 | Euro-Celtique, S.A. | Immediate release tablet cores of insoluble drugs having sustained-release coating |
DE4341442C2 (en) | 1993-12-04 | 1998-11-05 | Lohmann Therapie Syst Lts | Device for the controlled release of active substances and their use |
US5429226A (en) | 1993-12-15 | 1995-07-04 | Rexnord Corporation | Conveyor chain for carrying objects |
JPH07281423A (en) | 1994-04-07 | 1995-10-27 | Konica Corp | Plate making method of printing plate |
JP3518556B2 (en) | 1994-05-11 | 2004-04-12 | 株式会社紀文食品 | Gel coagulated food |
US5464633A (en) | 1994-05-24 | 1995-11-07 | Jagotec Ag | Pharmaceutical tablets releasing the active substance after a definite period of time |
US6020002A (en) | 1994-06-14 | 2000-02-01 | Fuisz Technologies Ltd. | Delivery of controlled-release system(s) |
US5672364A (en) | 1994-07-07 | 1997-09-30 | Sankyo Seisakusho Co. & Eisai Co., Ltd. | Apparatus for manufacturing tablets |
US5525179A (en) * | 1994-07-18 | 1996-06-11 | Empe-Werke Ernst Pelz Gmbh & Co. Kg | Method of manufacturing a lining part |
US5788979A (en) | 1994-07-22 | 1998-08-04 | Inflow Dynamics Inc. | Biodegradable coating with inhibitory properties for application to biocompatible materials |
IT1274034B (en) | 1994-07-26 | 1997-07-14 | Applied Pharma Res | PHARMACEUTICAL COMPOSITIONS BASED ON RUBBER TO BE CHEWED AND PROCEDURE FOR THEIR PREPARATION |
US6177125B1 (en) * | 1994-08-03 | 2001-01-23 | Gunter M. Voss | Method of producing coated tablets |
DE9414065U1 (en) | 1994-08-31 | 1994-11-03 | Roehm Gmbh | Thermoplastic plastic for pharmaceutical casings soluble in intestinal juice |
DE4431653C2 (en) | 1994-09-06 | 2000-01-20 | Lohmann Therapie Syst Lts | Coated tablet for the controlled release of active substances, a process for their preparation and their use |
US5614578A (en) * | 1994-10-28 | 1997-03-25 | Alza Corporation | Injection-molded dosage form |
US5756123A (en) | 1994-12-01 | 1998-05-26 | Japan Elanco Co., Ltd. | Capsule shell |
US5626896A (en) | 1994-12-09 | 1997-05-06 | A.E. Staley Manufacturing Co. | Method for making liquid-centered jelly candies |
DE4446468A1 (en) | 1994-12-23 | 1996-06-27 | Basf Ag | Process for the production of coated tablets |
DE59503520D1 (en) | 1995-02-07 | 1998-10-15 | Hermann Kronseder | Transport star for vessels |
DE29502547U1 (en) * | 1995-02-16 | 1995-03-30 | Roehm Gmbh | Thermoplastic coating and binding agent for pharmaceutical forms |
US5558879A (en) | 1995-04-28 | 1996-09-24 | Andrx Pharmaceuticals, Inc. | Controlled release formulation for water soluble drugs in which a passageway is formed in situ |
US5827874A (en) | 1995-05-05 | 1998-10-27 | Meyer; Hans | Methods of treating pain and inflammation with proline |
AU5655296A (en) | 1995-05-09 | 1996-11-29 | Colorcon Limited | Electrostatic coating |
EP0743267B1 (en) | 1995-05-13 | 1999-02-03 | Hermann Kronseder | Star coneyor for vessels |
US5578336A (en) * | 1995-06-07 | 1996-11-26 | Monte; Woodrow C. | Confection carrier for vitamins, enzymes, phytochemicals and ailmentary vegetable compositions and method of making |
US5614207A (en) * | 1995-06-30 | 1997-03-25 | Mcneil-Ppc, Inc. | Dry mouth lozenge |
GB9517031D0 (en) | 1995-08-19 | 1995-10-25 | Procter & Gamble | Confection compositions |
AUPN605795A0 (en) | 1995-10-19 | 1995-11-09 | F.H. Faulding & Co. Limited | Analgesic pharmaceutical composition |
DE19539361A1 (en) | 1995-10-23 | 1997-04-24 | Basf Ag | Process for the preparation of multilayer, solid pharmaceutical forms for oral or rectal administration |
IT1279673B1 (en) | 1995-11-07 | 1997-12-16 | Acma Spa | EQUIPMENT AND METHOD FOR THE FORMATION OF ORDERED GROUPS OF PRODUCTS TO BE FOOD BY STEP. |
US5733578A (en) | 1995-11-15 | 1998-03-31 | Edward Mendell Co., Inc. | Directly compressible high load acetaminophen formulations |
US5807579A (en) | 1995-11-16 | 1998-09-15 | F.H. Faulding & Co. Limited | Pseudoephedrine combination pharmaceutical compositions |
AU1366297A (en) | 1995-12-22 | 1997-07-17 | A/S Bruel & Kjaer | A system and a method for measuring a continuous signal |
US5813513A (en) | 1995-12-26 | 1998-09-29 | Redicon Corporation | Conveyor apparatus |
US5643984A (en) | 1996-01-03 | 1997-07-01 | Flint Ink Corporation | New Wax composition for the printing ink industry and ink compositions and overprint varnishes containing same |
US5879728A (en) | 1996-01-29 | 1999-03-09 | Warner-Lambert Company | Chewable confectionary composition and method of preparing same |
CN1137926A (en) | 1996-02-05 | 1996-12-18 | 杨满寿 | Chinese caterpillar fungus with protective layer and its making method |
IT1282576B1 (en) | 1996-02-06 | 1998-03-31 | Jagotec Ag | PHARMACEUTICAL TABLET SUITABLE TO GIVE THE ACTIVE SUBSTANCE IN SUBSEQUENT AND PREDETERMINABLE TIMES |
NL1003057C2 (en) | 1996-05-07 | 1997-11-10 | Greefs Wagen Carrosserie | Apparatus and method for supplying, removing and transferring objects, such as fruits. |
US5711691A (en) * | 1996-05-13 | 1998-01-27 | Air Packaging Technologies, Inc. | Self-closing and self-sealing valve device for use with inflatable structures |
US5824338A (en) | 1996-08-19 | 1998-10-20 | L. Perrigo Company | Caplet and gelatin covering therefor |
US5916881A (en) | 1996-10-07 | 1999-06-29 | Kabushiki Kaisha Hayashibara Seibutsu Kagaku Kenkyujo | High trehalose content syrup |
US6077539A (en) | 1996-11-12 | 2000-06-20 | Pozen, Inc. | Treatment of migraine headache |
GB9624110D0 (en) | 1996-11-20 | 1997-01-08 | Molins Plc | Transferring rod like articles |
FR2757173A1 (en) | 1996-12-17 | 1998-06-19 | Warner Lambert Co | POLYMERIC COMPOSITIONS OF NON-ANIMAL ORIGIN FOR FILM FORMATION |
US5827548A (en) | 1997-01-14 | 1998-10-27 | Lisco, Inc. | Golf ball injection mold |
US5996768A (en) | 1997-01-22 | 1999-12-07 | R. W. Hartnett Company | Quick change drum |
US5922352A (en) | 1997-01-31 | 1999-07-13 | Andrx Pharmaceuticals, Inc. | Once daily calcium channel blocker tablet having a delayed release core |
DE19710213A1 (en) | 1997-03-12 | 1998-09-17 | Basf Ag | Process for the manufacture of solid combination dosage forms |
US6210710B1 (en) | 1997-04-28 | 2001-04-03 | Hercules Incorporated | Sustained release polymer blend for pharmaceutical applications |
US5837301A (en) | 1997-04-28 | 1998-11-17 | Husky Injection Molding Systems Ltd. | Injection molding machine having a high speed turret |
US6149939A (en) | 1997-05-09 | 2000-11-21 | Strumor; Mathew A. | Healthful dissolvable oral tablets, and mini-bars |
AU7755398A (en) | 1997-06-25 | 1999-01-19 | Ipr-Institute For Pharmaceutical Research Ag | Method for reducing body weight |
ES2235337T3 (en) | 1997-07-09 | 2005-07-01 | Swiss Caps Rechte Und Lizenzen Ag | PROCEDURE AND DEVICE FOR MANUFACTURING A MULTI-PATH PHARMACEUTICAL FORM, PHYSIOLOGICALLY TOLERABLE. |
US6103260A (en) | 1997-07-17 | 2000-08-15 | Mcneil-Ppc, Inc. | Simethicone/anhydrous calcium phosphate compositions |
US5942034A (en) | 1997-07-24 | 1999-08-24 | Bayer Corporation | Apparatus for the gelatin coating of medicaments |
US5840334A (en) | 1997-08-20 | 1998-11-24 | Fuisz Technologies Ltd. | Self-binding shearform compositions |
CA2307887A1 (en) | 1997-10-31 | 1999-05-14 | Monsanto Company | Gellan gum tablet coating |
CA2315088A1 (en) | 1997-12-19 | 1999-07-01 | Smithkline Beecham Corporation | Process for manufacturing bite-dispersion tablets |
ID25786A (en) | 1997-12-26 | 2000-11-02 | Warner Lambert Co | GELATIN COMPOSITION |
US5962053A (en) | 1998-02-17 | 1999-10-05 | Viskase Corporation | Edible film and method |
US6432442B1 (en) | 1998-02-23 | 2002-08-13 | Mcneil-Ppc, Inc. | Chewable product |
US6099859A (en) | 1998-03-20 | 2000-08-08 | Andrx Pharmaceuticals, Inc. | Controlled release oral tablet having a unitary core |
US6365185B1 (en) * | 1998-03-26 | 2002-04-02 | University Of Cincinnati | Self-destructing, controlled release peroral drug delivery system |
US6372254B1 (en) | 1998-04-02 | 2002-04-16 | Impax Pharmaceuticals Inc. | Press coated, pulsatile drug delivery system suitable for oral administration |
FR2778135B1 (en) * | 1998-04-30 | 2000-07-07 | Plastic Omnium Cie | PROCESS FOR PRODUCING A PART IN PLASTIC MATERIAL PARTIALLY COATED WITH A FILM, ESPECIALLY DECORATIVE |
ES2255266T3 (en) | 1998-05-01 | 2006-06-16 | Duramed Pharmaceuticals, Inc. | MANUFACTURING PROCEDURE FOR MOLDING PO INJECTION FOR CONTROLLED RELEASE DEVICES AND DEVICE AS PRODUCED. |
US6365183B1 (en) | 1998-05-07 | 2002-04-02 | Alza Corporation | Method of fabricating a banded prolonged release active agent dosage form |
EP1077065B1 (en) | 1998-05-15 | 2004-08-04 | Chugai Seiyaku Kabushiki Kaisha | Controlled release formulations |
JP2002516848A (en) | 1998-06-03 | 2002-06-11 | アルザ・コーポレーション | Method and apparatus for providing long-term medication |
US6106267A (en) * | 1998-06-05 | 2000-08-22 | Aylward; John T. | Apparatus for forming a compression-molded product |
ES2157726B1 (en) | 1998-06-12 | 2002-03-01 | Bonals S A J | PERFECTION IN THE ROTATING MACHINES FOR THE MANUFACTURE OF TABLETS. |
US6103257A (en) * | 1998-07-17 | 2000-08-15 | Num-Pop, Inc. | System for delivering pharmaceuticals to the buccal mucosa |
DE19834180A1 (en) | 1998-07-29 | 2000-02-03 | Benckiser Nv | Composition for use in a dishwasher |
US6200590B1 (en) * | 1998-08-10 | 2001-03-13 | Naphcare, Inc. | Controlled, phased-release suppository and its method of production |
US6270790B1 (en) | 1998-08-18 | 2001-08-07 | Mxneil-Ppc, Inc. | Soft, convex shaped chewable tablets having reduced friability |
DE19840256A1 (en) * | 1998-09-03 | 2000-03-09 | Basf Ag | Widely applicable, continuous method for preparing coated solid dosage forms, comprises extruding mixture of drug and thermoplastic binder then applying coating composition in liquid or vapor form |
US5997905A (en) | 1998-09-04 | 1999-12-07 | Mcneil-Ppc | Preparation of pharmaceutically active particles |
US6174547B1 (en) * | 1999-07-14 | 2001-01-16 | Alza Corporation | Dosage form comprising liquid formulation |
US6602521B1 (en) | 1998-09-29 | 2003-08-05 | Impax Pharmaceuticals, Inc. | Multiplex drug delivery system suitable for oral administration |
DE19847618A1 (en) * | 1998-10-15 | 2000-04-20 | Basf Ag | Production of solid dosage forms, used for e.g. pharmaceuticals or insecticides, by preparation of plastic mixture from polymeric binder and active agent under controlled conditions |
US6322819B1 (en) | 1998-10-21 | 2001-11-27 | Shire Laboratories, Inc. | Oral pulsed dose drug delivery system |
US6165512A (en) | 1998-10-30 | 2000-12-26 | Fuisz Technologies Ltd. | Dosage forms containing taste masked active agents |
US6485747B1 (en) | 1998-10-30 | 2002-11-26 | Monsanto Company | Coated active tablet(s) |
JP3193912B2 (en) * | 1998-11-02 | 2001-07-30 | 住友特殊金属株式会社 | Powder pressing apparatus and powder pressing method |
US6482349B1 (en) * | 1998-11-02 | 2002-11-19 | Sumitomo Special Metals Co., Ltd. | Powder pressing apparatus and powder pressing method |
US6270805B1 (en) | 1998-11-06 | 2001-08-07 | Andrx Pharmaceuticals, Inc. | Two pellet controlled release formulation for water soluble drugs which contains an alkaline metal stearate |
DE19853985A1 (en) * | 1998-11-23 | 2000-05-25 | Basf Ag | Producing solid dosage form, using molding calender of two cylinders with specific surface structures, avoids problems of misalignment of upper and lower halves of the product |
US6405853B1 (en) | 1998-11-24 | 2002-06-18 | Steven T. Cook | Conveyor system for can end conversion systems |
US6183681B1 (en) * | 1998-12-07 | 2001-02-06 | Centurion International, Inc. | Multi-stage insert molding method |
DE19901383A1 (en) * | 1999-01-15 | 2000-07-20 | Knoll Ag | Process for the preparation of different solid dosage forms |
US6276917B1 (en) | 1999-01-28 | 2001-08-21 | Botanicals International | Powder processing apparatus |
DE59901613D1 (en) | 1999-02-10 | 2002-07-11 | Suwelack Skin & Health Care Ag | Freeze-dried product containing Euglena beta-1,3-glucan, its manufacture and use |
US6274162B1 (en) | 2000-01-14 | 2001-08-14 | Bpsi Holdings, Inc. | Elegant film coating system |
US6248760B1 (en) * | 1999-04-14 | 2001-06-19 | Paul C Wilhelmsen | Tablet giving rapid release of nicotine for transmucosal administration |
AU5704200A (en) | 1999-06-29 | 2001-01-31 | Taisho Pharmaceutical Co., Ltd. | Dry coated tablet and method for producing the same and production system |
JP2001072579A (en) | 1999-06-29 | 2001-03-21 | Taisho Pharmaceut Co Ltd | Core-containing tablet and method and system for its production |
DE19941997A1 (en) | 1999-09-02 | 2001-03-08 | Gunther Meinhardt Voss | Method and device for producing a tablet or the like |
GB9921933D0 (en) | 1999-09-17 | 1999-11-17 | Univ Gent | Solid shaped articles comprising biologically active substances and a method for their production |
AU1195001A (en) | 1999-10-11 | 2001-04-23 | Monsanto Company | Tablets coated with locust bean gum, guar gum or carrageenan gum |
DE19954420A1 (en) | 1999-11-12 | 2001-05-31 | Lohmann Therapie Syst Lts | Preparation consisting of a film, foil or wafer-like dosage form with a two-layer structure and integrated labeling |
DE19960494A1 (en) | 1999-12-15 | 2001-06-21 | Knoll Ag | Device and method for producing solid active substance-containing forms |
DE19963569B4 (en) | 1999-12-29 | 2006-11-16 | Reckitt Benckiser N.V. | Composition for use in a dishwasher |
WO2001056550A1 (en) | 2000-02-01 | 2001-08-09 | Monsanto Company | Gellan gum dipped products |
US20020028240A1 (en) * | 2000-04-17 | 2002-03-07 | Toyohiro Sawada | Timed-release compression-coated solid composition for oral administration |
US6499984B1 (en) * | 2000-05-22 | 2002-12-31 | Warner-Lambert Company | Continuous production of pharmaceutical granulation |
WO2002019833A2 (en) | 2000-09-07 | 2002-03-14 | Akpharma Inc. | Edible candy compositions and methods of using the same |
EP1365738A2 (en) * | 2001-01-26 | 2003-12-03 | Bausch & Lomb Incorporated | Improved process for the production of sustained release drug delivery devices |
US6558722B2 (en) | 2001-07-18 | 2003-05-06 | Wm. Wrigley Jr. Company | Use of powdered gum in making a coating for a confection |
GB0120835D0 (en) | 2001-08-28 | 2001-10-17 | Smithkline Beecham Plc | Process |
US6767200B2 (en) | 2001-09-28 | 2004-07-27 | Mcneil-Ppc, Inc. | Systems, methods and apparatuses for manufacturing dosage forms |
US7838026B2 (en) | 2001-09-28 | 2010-11-23 | Mcneil-Ppc, Inc. | Burst-release polymer composition and dosage forms comprising the same |
US7323192B2 (en) | 2001-09-28 | 2008-01-29 | Mcneil-Ppc, Inc. | Immediate release tablet |
US6982094B2 (en) | 2001-09-28 | 2006-01-03 | Mcneil-Ppc, Inc. | Systems, methods and apparatuses for manufacturing dosage forms |
US7217381B2 (en) | 2001-09-28 | 2007-05-15 | Mcneil-Ppc, Inc. | Systems, methods and apparatuses for manufacturing dosage forms |
US6837696B2 (en) | 2001-09-28 | 2005-01-04 | Mcneil-Ppc, Inc. | Apparatus for manufacturing dosage forms |
US6742646B2 (en) | 2001-09-28 | 2004-06-01 | Mcneil-Ppc, Inc. | Systems, methods and apparatuses for manufacturing dosage forms |
US7122143B2 (en) | 2001-09-28 | 2006-10-17 | Mcneil-Ppc, Inc. | Methods for manufacturing dosage forms |
CN1688291A (en) | 2002-02-01 | 2005-10-26 | 辉瑞产品公司 | Immediate release dosage forms containing solid drug dispersions |
-
2001
- 2001-09-28 US US09/966,497 patent/US7122143B2/en not_active Expired - Lifetime
-
2002
- 2002-09-26 JP JP2003531956A patent/JP2005504589A/en not_active Ceased
- 2002-09-26 EP EP02768902A patent/EP1432378B1/en not_active Expired - Lifetime
- 2002-09-26 AT AT02768902T patent/ATE418953T1/en not_active IP Right Cessation
- 2002-09-26 CN CNA028216652A patent/CN1635863A/en active Pending
- 2002-09-26 CA CA2461873A patent/CA2461873C/en not_active Expired - Fee Related
- 2002-09-26 WO PCT/US2002/030650 patent/WO2003028619A2/en active Application Filing
- 2002-09-26 MX MXPA04002969A patent/MXPA04002969A/en unknown
- 2002-09-26 KR KR10-2004-7004678A patent/KR20040039459A/en not_active Application Discontinuation
- 2002-09-26 DE DE60230649T patent/DE60230649D1/en not_active Expired - Lifetime
-
2004
- 2004-08-04 US US10/911,263 patent/US8114328B2/en not_active Expired - Fee Related
-
2011
- 2011-12-07 US US13/313,504 patent/US8673190B2/en not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
JP2005504589A (en) | 2005-02-17 |
DE60230649D1 (en) | 2009-02-12 |
US7122143B2 (en) | 2006-10-17 |
US8673190B2 (en) | 2014-03-18 |
ATE418953T1 (en) | 2009-01-15 |
US20030086973A1 (en) | 2003-05-08 |
KR20040039459A (en) | 2004-05-10 |
WO2003028619A2 (en) | 2003-04-10 |
CA2461873C (en) | 2012-10-30 |
EP1432378A1 (en) | 2004-06-30 |
US20050008696A1 (en) | 2005-01-13 |
US8114328B2 (en) | 2012-02-14 |
MXPA04002969A (en) | 2005-06-20 |
EP1432378B1 (en) | 2008-12-31 |
CN1635863A (en) | 2005-07-06 |
US20120074614A1 (en) | 2012-03-29 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
CA2461873A1 (en) | Systems, methods and apparatuses for manufacturing dosage forms | |
US7384587B2 (en) | Method for post mold cooling of plastic pieces | |
JP3258282B2 (en) | Sprue gate type 5-layer injection molding machine | |
AU637016B2 (en) | Shooting pot with combined valve and piston | |
CN104324866B (en) | In the groove of workpiece, inject the method for fluid sealant | |
US6274075B1 (en) | Five layer injection molding apparatus having four position valve member actuating mechanism | |
CA1259156A (en) | Fluid cooled hydraulic actuating mechanism for single cavity injection molding | |
US4747770A (en) | Fluid cooled hydraulic actuating mechanism for injection molding | |
CA2462008A1 (en) | Systems, methods and apparatuses for manufacturing dosage forms | |
JPS6154575B2 (en) | ||
JPH01128814A (en) | Injection molding method and device for thermoplastic synthetic-resin molded form | |
JPH078501B2 (en) | Air / water feeder for shell mold | |
EP0893226B1 (en) | Back-to-back valve gate system | |
US20020086074A1 (en) | Direct cavity gate golf ball injection mold | |
US4082486A (en) | Apparatus for in-the-mold coating of molded articles | |
TW200840702A (en) | Inlet nozzle for hot runner system | |
US9302416B1 (en) | Single nozzle valve gate | |
KR102603280B1 (en) | Spray cooling system for die casting molding | |
CA2190569C (en) | Injection molding nozzle with edge gate inserts and sealing ring | |
US20040164460A1 (en) | Method for producing an article of plastics by injection molding | |
CN100556656C (en) | Be used to handle the method and apparatus on the surface that is molded and assembles | |
US11420378B2 (en) | Core rod assembly for blow molding and having multiple temperature zones | |
JP3728856B2 (en) | Plastic product manufacturing equipment | |
CN206186257U (en) | Cylinder body subassembly and have its hot runner system | |
KR20170001463A (en) | LSR Valve nozzle for an injection molding device |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
EEER | Examination request | ||
MKLA | Lapsed |
Effective date: 20180926 |