CA2453430A1 - Optical sensor containing particles for in situ measurement of analytes - Google Patents
Optical sensor containing particles for in situ measurement of analytes Download PDFInfo
- Publication number
- CA2453430A1 CA2453430A1 CA002453430A CA2453430A CA2453430A1 CA 2453430 A1 CA2453430 A1 CA 2453430A1 CA 002453430 A CA002453430 A CA 002453430A CA 2453430 A CA2453430 A CA 2453430A CA 2453430 A1 CA2453430 A1 CA 2453430A1
- Authority
- CA
- Canada
- Prior art keywords
- sensor
- analyte
- particles
- chromophore
- macrophages
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue
- A61B5/14532—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue for measuring glucose, e.g. by tissue impedance measurement
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue
- A61B5/1468—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue using chemical or electrochemical methods, e.g. by polarographic means
- A61B5/1473—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue using chemical or electrochemical methods, e.g. by polarographic means invasive, e.g. introduced into the body by a catheter
- A61B5/14735—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue using chemical or electrochemical methods, e.g. by polarographic means invasive, e.g. introduced into the body by a catheter comprising an immobilised reagent
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/41—Detecting, measuring or recording for evaluating the immune or lymphatic systems
- A61B5/414—Evaluating particular organs or parts of the immune or lymphatic systems
- A61B5/415—Evaluating particular organs or parts of the immune or lymphatic systems the glands, e.g. tonsils, adenoids or thymus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/41—Detecting, measuring or recording for evaluating the immune or lymphatic systems
- A61B5/414—Evaluating particular organs or parts of the immune or lymphatic systems
- A61B5/417—Evaluating particular organs or parts of the immune or lymphatic systems the bone marrow
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/41—Detecting, measuring or recording for evaluating the immune or lymphatic systems
- A61B5/414—Evaluating particular organs or parts of the immune or lymphatic systems
- A61B5/418—Evaluating particular organs or parts of the immune or lymphatic systems lymph vessels, ducts or nodes
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
- G01N33/54366—Apparatus specially adapted for solid-phase testing
- G01N33/54373—Apparatus specially adapted for solid-phase testing involving physiochemical end-point determination, e.g. wave-guides, FETS, gratings
Abstract
The invention relates to a sensor for the in vivo measurement of an analyte, comprising a plurality of particles of suitable size such that when implante d in the body of a mammal the particles can be ingested by macrophages and transported away from the site of implantation, each particle containing the components of an assay having a readout which is an optical signal detectabl e transdermally by external optical means, and either each particles being contained within a biodegradable material preventing ingestion by the macrophages, or each particle being non-biodegradable. The invention relates to a process for the detection of an analyte using such a sensor, comprising implantation of the sensor into the skin of a mammal, transdermal detection of analyte using external optical means, degradation of the biodegradable material, ingestion of the particles by macrophages, and removal of the particles from the site of implantation by macrophages.
Claims (11)
1. A sensor for the in vivo measurement of an analyte, comprising a plurality of particles of suitable size such that when implanted in the body of a mammal the particles can be ingested by macrophages and transported away from the site of implantation, each particle containing the components of an assay having a readout which is an optical signal detectable or measurable transdermally by external optical means, and either each particle being contained within a biodegradable material preventing ingestion by the macrophages, or each particle being non-biodegradable.
2. A sensor as claimed in Claim 1, wherein the particles are less than 5 µm in their largest dimension.
3. A sensor as claimed in either one of Claims 1 or 2, wherein the biodegradable material is present and is a gel.
4. A sensor as claimed in any one of the preceding claims, wherein the assay is a binding assay.
5. A sensor as claimed in Claim 4, wherein the binding assay is a competitive binding assay, the components of which include an analyte binding agent and an analyte analogue.
6. A sensor as claimed in Claim 5, wherein the analyte analogue is labelled with a first chromophore and the analyte binding agent is labelled with a second chromophore, the emission spectrum of the first chromophore or second chromophore overlapping with the absorption spectrum of the second chromophore or first chromophore respectively.
7. A sensor as claimed in either one of Claims 5 or 6, wherein the binding agent is an antibody, a Fab fragment, a lectin, a hormone receptor, a drug receptor, an aptamer or a molecularly-imprinted polymer.
8. A sensor as claimed in any one of the preceding claims, wherein the detectable or measurable optical signal is generated by fluorescence resonance energy transfer, fluorescence polarisation, fluorescence quenching, phosphorescence, luminescence enhancement, luminescence quenching, diffraction or plasmon resonance.
9. A sensor as claimed in any one of the preceding claims, wherein the particles are non-biodegradable.
10. A sensor as claimed in any one of the preceding claims, wherein the analyte is glucose.
11. A process for the detection of an analyte using a sensor as claimed in any one of the preceding claims, comprising implantation of the sensor into the skin of a mammmal, transdermal detection or measurement of analyte using external optical means, degradation of the biodegradable material, ingestion of the particles by macrophages, and removal of the particles from the site of implantation by macrophages.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GBGB0116853.3A GB0116853D0 (en) | 2001-07-10 | 2001-07-10 | Optical sensor containing particles for in SITU measurement of analytes |
GB0116853.3 | 2001-07-10 | ||
PCT/EP2002/007108 WO2003006992A1 (en) | 2001-07-10 | 2002-06-27 | Optical sensor containing particles for in situ measurement of analytes |
Publications (2)
Publication Number | Publication Date |
---|---|
CA2453430A1 true CA2453430A1 (en) | 2003-01-23 |
CA2453430C CA2453430C (en) | 2010-11-09 |
Family
ID=9918250
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CA2453430A Expired - Fee Related CA2453430C (en) | 2001-07-10 | 2002-06-27 | Optical sensor containing particles for in situ measurement of analytes |
Country Status (12)
Country | Link |
---|---|
US (1) | US7228159B2 (en) |
EP (1) | EP1405075B1 (en) |
JP (1) | JP4280629B2 (en) |
AT (1) | ATE420356T1 (en) |
CA (1) | CA2453430C (en) |
DE (1) | DE60230758D1 (en) |
DK (1) | DK1405075T3 (en) |
ES (1) | ES2316606T3 (en) |
GB (1) | GB0116853D0 (en) |
NO (1) | NO332247B1 (en) |
NZ (1) | NZ530928A (en) |
WO (1) | WO2003006992A1 (en) |
Families Citing this family (97)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6036924A (en) | 1997-12-04 | 2000-03-14 | Hewlett-Packard Company | Cassette of lancet cartridges for sampling blood |
US6391005B1 (en) | 1998-03-30 | 2002-05-21 | Agilent Technologies, Inc. | Apparatus and method for penetration with shaft having a sensor for sensing penetration depth |
US8641644B2 (en) | 2000-11-21 | 2014-02-04 | Sanofi-Aventis Deutschland Gmbh | Blood testing apparatus having a rotatable cartridge with multiple lancing elements and testing means |
WO2002100460A2 (en) | 2001-06-12 | 2002-12-19 | Pelikan Technologies, Inc. | Electric lancet actuator |
EP1404232B1 (en) | 2001-06-12 | 2009-12-02 | Pelikan Technologies Inc. | Blood sampling apparatus and method |
US9795747B2 (en) | 2010-06-02 | 2017-10-24 | Sanofi-Aventis Deutschland Gmbh | Methods and apparatus for lancet actuation |
US7041068B2 (en) | 2001-06-12 | 2006-05-09 | Pelikan Technologies, Inc. | Sampling module device and method |
US7316700B2 (en) | 2001-06-12 | 2008-01-08 | Pelikan Technologies, Inc. | Self optimizing lancing device with adaptation means to temporal variations in cutaneous properties |
US7981056B2 (en) | 2002-04-19 | 2011-07-19 | Pelikan Technologies, Inc. | Methods and apparatus for lancet actuation |
ES2357887T3 (en) | 2001-06-12 | 2011-05-03 | Pelikan Technologies Inc. | APPARATUS FOR IMPROVING THE BLOOD OBTAINING SUCCESS RATE FROM A CAPILLARY PUNCTURE. |
AU2002348683A1 (en) | 2001-06-12 | 2002-12-23 | Pelikan Technologies, Inc. | Method and apparatus for lancet launching device integrated onto a blood-sampling cartridge |
US9226699B2 (en) | 2002-04-19 | 2016-01-05 | Sanofi-Aventis Deutschland Gmbh | Body fluid sampling module with a continuous compression tissue interface surface |
US9427532B2 (en) | 2001-06-12 | 2016-08-30 | Sanofi-Aventis Deutschland Gmbh | Tissue penetration device |
US8337419B2 (en) | 2002-04-19 | 2012-12-25 | Sanofi-Aventis Deutschland Gmbh | Tissue penetration device |
US7232451B2 (en) | 2002-04-19 | 2007-06-19 | Pelikan Technologies, Inc. | Method and apparatus for penetrating tissue |
US8372016B2 (en) | 2002-04-19 | 2013-02-12 | Sanofi-Aventis Deutschland Gmbh | Method and apparatus for body fluid sampling and analyte sensing |
US7909778B2 (en) | 2002-04-19 | 2011-03-22 | Pelikan Technologies, Inc. | Method and apparatus for penetrating tissue |
US8702624B2 (en) | 2006-09-29 | 2014-04-22 | Sanofi-Aventis Deutschland Gmbh | Analyte measurement device with a single shot actuator |
US7371247B2 (en) | 2002-04-19 | 2008-05-13 | Pelikan Technologies, Inc | Method and apparatus for penetrating tissue |
US9795334B2 (en) | 2002-04-19 | 2017-10-24 | Sanofi-Aventis Deutschland Gmbh | Method and apparatus for penetrating tissue |
US7331931B2 (en) | 2002-04-19 | 2008-02-19 | Pelikan Technologies, Inc. | Method and apparatus for penetrating tissue |
US7491178B2 (en) | 2002-04-19 | 2009-02-17 | Pelikan Technologies, Inc. | Method and apparatus for penetrating tissue |
US8267870B2 (en) | 2002-04-19 | 2012-09-18 | Sanofi-Aventis Deutschland Gmbh | Method and apparatus for body fluid sampling with hybrid actuation |
US7901362B2 (en) | 2002-04-19 | 2011-03-08 | Pelikan Technologies, Inc. | Method and apparatus for penetrating tissue |
US7717863B2 (en) | 2002-04-19 | 2010-05-18 | Pelikan Technologies, Inc. | Method and apparatus for penetrating tissue |
US9314194B2 (en) | 2002-04-19 | 2016-04-19 | Sanofi-Aventis Deutschland Gmbh | Tissue penetration device |
US7175642B2 (en) | 2002-04-19 | 2007-02-13 | Pelikan Technologies, Inc. | Methods and apparatus for lancet actuation |
US8360992B2 (en) | 2002-04-19 | 2013-01-29 | Sanofi-Aventis Deutschland Gmbh | Method and apparatus for penetrating tissue |
US7674232B2 (en) | 2002-04-19 | 2010-03-09 | Pelikan Technologies, Inc. | Method and apparatus for penetrating tissue |
US7648468B2 (en) | 2002-04-19 | 2010-01-19 | Pelikon Technologies, Inc. | Method and apparatus for penetrating tissue |
US7708701B2 (en) | 2002-04-19 | 2010-05-04 | Pelikan Technologies, Inc. | Method and apparatus for a multi-use body fluid sampling device |
US7547287B2 (en) | 2002-04-19 | 2009-06-16 | Pelikan Technologies, Inc. | Method and apparatus for penetrating tissue |
US7229458B2 (en) | 2002-04-19 | 2007-06-12 | Pelikan Technologies, Inc. | Method and apparatus for penetrating tissue |
US7892183B2 (en) | 2002-04-19 | 2011-02-22 | Pelikan Technologies, Inc. | Method and apparatus for body fluid sampling and analyte sensing |
US8784335B2 (en) | 2002-04-19 | 2014-07-22 | Sanofi-Aventis Deutschland Gmbh | Body fluid sampling device with a capacitive sensor |
US9248267B2 (en) | 2002-04-19 | 2016-02-02 | Sanofi-Aventis Deustchland Gmbh | Tissue penetration device |
US8221334B2 (en) | 2002-04-19 | 2012-07-17 | Sanofi-Aventis Deutschland Gmbh | Method and apparatus for penetrating tissue |
US7297122B2 (en) | 2002-04-19 | 2007-11-20 | Pelikan Technologies, Inc. | Method and apparatus for penetrating tissue |
US8579831B2 (en) | 2002-04-19 | 2013-11-12 | Sanofi-Aventis Deutschland Gmbh | Method and apparatus for penetrating tissue |
US7976476B2 (en) | 2002-04-19 | 2011-07-12 | Pelikan Technologies, Inc. | Device and method for variable speed lancet |
US7291117B2 (en) | 2002-04-19 | 2007-11-06 | Pelikan Technologies, Inc. | Method and apparatus for penetrating tissue |
US20040082080A1 (en) | 2002-08-01 | 2004-04-29 | Wolf David E. | Method of measuring molecular interactions |
US8574895B2 (en) | 2002-12-30 | 2013-11-05 | Sanofi-Aventis Deutschland Gmbh | Method and apparatus using optical techniques to measure analyte levels |
ES2347248T3 (en) | 2003-05-30 | 2010-10-27 | Pelikan Technologies Inc. | PROCEDURE AND APPLIANCE FOR FLUID INJECTION. |
US7850621B2 (en) | 2003-06-06 | 2010-12-14 | Pelikan Technologies, Inc. | Method and apparatus for body fluid sampling and analyte sensing |
WO2006001797A1 (en) | 2004-06-14 | 2006-01-05 | Pelikan Technologies, Inc. | Low pain penetrating |
WO2005033659A2 (en) | 2003-09-29 | 2005-04-14 | Pelikan Technologies, Inc. | Method and apparatus for an improved sample capture device |
US9351680B2 (en) | 2003-10-14 | 2016-05-31 | Sanofi-Aventis Deutschland Gmbh | Method and apparatus for a variable user interface |
US8668656B2 (en) | 2003-12-31 | 2014-03-11 | Sanofi-Aventis Deutschland Gmbh | Method and apparatus for improving fluidic flow and sample capture |
US7822454B1 (en) | 2005-01-03 | 2010-10-26 | Pelikan Technologies, Inc. | Fluid sampling device with improved analyte detecting member configuration |
GB0411162D0 (en) * | 2004-05-19 | 2004-06-23 | Precisense As | Optical sensor for in vivo detection of analyte |
US8828203B2 (en) | 2004-05-20 | 2014-09-09 | Sanofi-Aventis Deutschland Gmbh | Printable hydrogels for biosensors |
EP1765194A4 (en) | 2004-06-03 | 2010-09-29 | Pelikan Technologies Inc | Method and apparatus for a fluid sampling device |
US9775553B2 (en) | 2004-06-03 | 2017-10-03 | Sanofi-Aventis Deutschland Gmbh | Method and apparatus for a fluid sampling device |
GB0426823D0 (en) | 2004-12-07 | 2005-01-12 | Precisense As | Sensor for detection of glucose |
GB0426822D0 (en) | 2004-12-07 | 2005-01-12 | Precisense As | Sensor for detection of glucose |
US8652831B2 (en) | 2004-12-30 | 2014-02-18 | Sanofi-Aventis Deutschland Gmbh | Method and apparatus for analyte measurement test time |
JP5033810B2 (en) * | 2005-12-07 | 2012-09-26 | プレシセンス・エー/エス | Sensor having polymer having flexible carbohydrate and method for synthesizing polymer therefor |
US8126554B2 (en) | 2006-05-17 | 2012-02-28 | Cardiac Pacemakers, Inc. | Implantable medical device with chemical sensor and related methods |
DE102007024642A1 (en) * | 2007-05-24 | 2008-11-27 | Eyesense Ag | Hydrogel implant for sensor of metabolites on the eye |
US9386944B2 (en) | 2008-04-11 | 2016-07-12 | Sanofi-Aventis Deutschland Gmbh | Method and apparatus for analyte detecting device |
US9375169B2 (en) | 2009-01-30 | 2016-06-28 | Sanofi-Aventis Deutschland Gmbh | Cam drive for managing disposable penetrating member actions with a single motor and motor and control system |
CA2716502C (en) | 2009-05-15 | 2015-06-16 | Interface Biologics, Inc. | Antithrombogenic hollow fiber membranes and filters |
US9517023B2 (en) | 2009-06-01 | 2016-12-13 | Profusa, Inc. | Method and system for directing a localized biological response to an implant |
US8554174B2 (en) | 2009-06-15 | 2013-10-08 | Alcatel Lucent | Selective first delivery attempt (FDA) processing for text messages |
US8795595B2 (en) | 2010-04-07 | 2014-08-05 | Medtronic Minimed, Inc. | Sensor substrate systems and methods |
US8965476B2 (en) | 2010-04-16 | 2015-02-24 | Sanofi-Aventis Deutschland Gmbh | Tissue penetration device |
US10010272B2 (en) | 2010-05-27 | 2018-07-03 | Profusa, Inc. | Tissue-integrating electronic apparatus |
EP2624744A4 (en) * | 2010-10-06 | 2017-03-29 | Profusa, Inc. | Tissue-integrating sensors |
US9642568B2 (en) | 2011-09-06 | 2017-05-09 | Medtronic Minimed, Inc. | Orthogonally redundant sensor systems and methods |
US8999720B2 (en) | 2011-11-17 | 2015-04-07 | Medtronic Minimed, Inc. | Aqueous radiation protecting formulations and methods for making and using them |
EP2967454B1 (en) | 2013-03-14 | 2020-04-22 | Profusa, Inc. | Method and device for correcting optical signals |
WO2014196169A1 (en) * | 2013-06-04 | 2014-12-11 | パナソニック株式会社 | Sensor chip, detection method and detection device |
EP3777656A1 (en) | 2013-06-06 | 2021-02-17 | Profusa, Inc. | Apparatus for detecting optical signals from implanted sensors |
US9936905B2 (en) | 2013-10-25 | 2018-04-10 | Medtronic Minimed, Inc. | Sensor with optical interface |
WO2016054079A1 (en) | 2014-09-29 | 2016-04-07 | Zyomed Corp. | Systems and methods for blood glucose and other analyte detection and measurement using collision computing |
CN106999118B (en) * | 2014-10-13 | 2020-07-17 | 葡萄糖传感器公司 | Analyte sensing device |
US9337040B1 (en) | 2014-12-05 | 2016-05-10 | Varian Semiconductor Equipment Associates, Inc. | Angled ion beam processing of heterogeneous structure |
KR102410471B1 (en) * | 2015-05-11 | 2022-06-17 | 삼성전자주식회사 | Needle for biosensor and bio sensor including the same |
US20160354500A1 (en) | 2015-06-02 | 2016-12-08 | Medtronic Minimed, Inc. | Protective agents against e-beam irradiation for proteins in optical sensing chemistry |
US10716500B2 (en) | 2015-06-29 | 2020-07-21 | Cardiac Pacemakers, Inc. | Systems and methods for normalization of chemical sensor data based on fluid state changes |
US9554738B1 (en) | 2016-03-30 | 2017-01-31 | Zyomed Corp. | Spectroscopic tomography systems and methods for noninvasive detection and measurement of analytes using collision computing |
US20170290535A1 (en) | 2016-04-08 | 2017-10-12 | Medtronic Minimed, Inc. | Analyte sensor with indicators |
WO2017195035A1 (en) * | 2016-05-10 | 2017-11-16 | Interface Biologics, Inc. | Implantable glucose sensors having a biostable surface |
EP3529300A4 (en) | 2016-10-18 | 2020-03-18 | Evonik Canada Inc. | Plasticized pvc admixtures with surface modifying macromolecules and articles made therefrom |
WO2018119400A1 (en) | 2016-12-22 | 2018-06-28 | Profusa, Inc. | System and single-channel luminescent sensor for and method of determining analyte value |
US10463285B2 (en) * | 2017-04-03 | 2019-11-05 | Medtronic, Inc. | Hermetically-sealed package and method of forming same |
US10543288B2 (en) | 2017-04-28 | 2020-01-28 | Medtronic Minimed, Inc. | Modified-dextrans for use in optical glucose assays |
US10792378B2 (en) | 2017-04-28 | 2020-10-06 | Medtronics Minimed, Inc. | Using a blue-shifted reference dye in an optical glucose assay |
CN108968976B (en) | 2017-05-31 | 2022-09-13 | 心脏起搏器股份公司 | Implantable medical device with chemical sensor |
CN109381195B (en) | 2017-08-10 | 2023-01-10 | 心脏起搏器股份公司 | Systems and methods including electrolyte sensor fusion |
CN109419515B (en) | 2017-08-23 | 2023-03-24 | 心脏起搏器股份公司 | Implantable chemical sensor with staged activation |
CN109864746B (en) | 2017-12-01 | 2023-09-29 | 心脏起搏器股份公司 | Multimode analyte sensor for medical devices |
CN109864747B (en) | 2017-12-05 | 2023-08-25 | 心脏起搏器股份公司 | Multimode analyte sensor optoelectronic interface |
US20210228128A1 (en) * | 2018-05-08 | 2021-07-29 | Abbott Diabetes Care Inc. | Sensing systems and methods for identifying emotional stress events |
TWM599631U (en) * | 2019-08-02 | 2020-08-11 | 華廣生技股份有限公司 | Physiological signal sensing device |
WO2023137339A1 (en) * | 2022-01-11 | 2023-07-20 | Basf Se | Screening the degradation of polymer microparticles on a chip |
Family Cites Families (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3996345A (en) | 1974-08-12 | 1976-12-07 | Syva Company | Fluorescence quenching with immunological pairs in immunoassays |
US4344438A (en) * | 1978-08-02 | 1982-08-17 | The United States Of America As Represented By The Department Of Health, Education And Welfare | Optical sensor of plasma constituents |
US5342789A (en) * | 1989-12-14 | 1994-08-30 | Sensor Technologies, Inc. | Method and device for detecting and quantifying glucose in body fluids |
US5628310A (en) * | 1995-05-19 | 1997-05-13 | Joseph R. Lakowicz | Method and apparatus to perform trans-cutaneous analyte monitoring |
WO1997019188A1 (en) | 1995-11-22 | 1997-05-29 | Minimed, Inc. | Detection of biological molecules using chemical amplification and optical sensors |
US6002817A (en) * | 1997-09-29 | 1999-12-14 | The Regents Of The University Of Michigan | Optical sensors for the detection of nitric oxide |
GB9814506D0 (en) * | 1998-07-03 | 1998-09-02 | Stanley Christopher J | Optical sensor for insitu measurement of analytes |
JP4812167B2 (en) | 1999-02-12 | 2011-11-09 | モレキュラー インサイト ファーマスーティカルズ インコーポレイテッド | Drug transport matrix and methods for making and using the same |
US6366793B1 (en) * | 1999-09-10 | 2002-04-02 | Beckman Coulter, Inc. | Minimally invasive methods for measuring analtes in vivo |
US6383767B1 (en) * | 2000-01-21 | 2002-05-07 | Motorola, Inc. | Luminescent in vivo glucose measurement |
-
2001
- 2001-07-10 GB GBGB0116853.3A patent/GB0116853D0/en not_active Ceased
-
2002
- 2002-06-27 CA CA2453430A patent/CA2453430C/en not_active Expired - Fee Related
- 2002-06-27 NZ NZ530928A patent/NZ530928A/en not_active IP Right Cessation
- 2002-06-27 JP JP2003512709A patent/JP4280629B2/en not_active Expired - Fee Related
- 2002-06-27 DK DK02764601T patent/DK1405075T3/en active
- 2002-06-27 WO PCT/EP2002/007108 patent/WO2003006992A1/en active IP Right Grant
- 2002-06-27 AT AT02764601T patent/ATE420356T1/en not_active IP Right Cessation
- 2002-06-27 EP EP02764601A patent/EP1405075B1/en not_active Expired - Lifetime
- 2002-06-27 US US10/483,426 patent/US7228159B2/en not_active Expired - Lifetime
- 2002-06-27 ES ES02764601T patent/ES2316606T3/en not_active Expired - Lifetime
- 2002-06-27 DE DE60230758T patent/DE60230758D1/en not_active Expired - Lifetime
-
2004
- 2004-01-09 NO NO20040098A patent/NO332247B1/en not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
CA2453430C (en) | 2010-11-09 |
US20040199062A1 (en) | 2004-10-07 |
GB0116853D0 (en) | 2001-09-05 |
ES2316606T3 (en) | 2009-04-16 |
NO332247B1 (en) | 2012-08-06 |
EP1405075B1 (en) | 2009-01-07 |
JP2004534255A (en) | 2004-11-11 |
ATE420356T1 (en) | 2009-01-15 |
DK1405075T3 (en) | 2009-04-20 |
JP4280629B2 (en) | 2009-06-17 |
DE60230758D1 (en) | 2009-02-26 |
NZ530928A (en) | 2005-02-25 |
EP1405075A1 (en) | 2004-04-07 |
US7228159B2 (en) | 2007-06-05 |
NO20040098L (en) | 2004-03-09 |
WO2003006992A1 (en) | 2003-01-23 |
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