CA2448347A1 - Novel human hydroxylases and polynucleotides encoding the same - Google Patents

Novel human hydroxylases and polynucleotides encoding the same Download PDF

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Publication number
CA2448347A1
CA2448347A1 CA002448347A CA2448347A CA2448347A1 CA 2448347 A1 CA2448347 A1 CA 2448347A1 CA 002448347 A CA002448347 A CA 002448347A CA 2448347 A CA2448347 A CA 2448347A CA 2448347 A1 CA2448347 A1 CA 2448347A1
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CA
Canada
Prior art keywords
seq
nucleic acid
isolated nucleic
molecule
nucleotide sequence
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA002448347A
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French (fr)
Other versions
CA2448347C (en
Inventor
Xuanchuan Yu
Maricar Miranda
Yi Hu
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Lexicon Pharmaceuticals Inc
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Individual
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Filing date
Publication date
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First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=23131776&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CA2448347(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Individual filed Critical Individual
Publication of CA2448347A1 publication Critical patent/CA2448347A1/en
Application granted granted Critical
Publication of CA2448347C publication Critical patent/CA2448347C/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/05—Animals comprising random inserted nucleic acids (transgenic)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide

Abstract

Novel human polynucleotide and polypeptide sequences are disclosed that can be used in industrial, therapeutic, diagnostic, and pharmacogenomic applications.

Claims (10)

1. An isolated nucleic acid molecule comprising the nucleotide sequence of SEQ ID NO:7.
2. The isolated nucleic acid molecule of claim 1, wherein the molecule comprises the nucleotide sequence of SEQ ID NO:5.
3. The isolated nucleic acid molecule of claim 2, wherein the molecule comprises the nucleotide sequence of SEQ ID NO:3.
4. The isolated nucleic acid molecule of claim 3, wherein the molecule comprises the nucleotide sequence of SEQ ID NO:1.
5. An isolated nucleic acid molecule comprising a nucleotide sequence that:
(a) encodes the amino acid sequence shown in SEQ ID NO:4; and (b) hybridizes under highly stringent conditions to the nucleotide sequence of SEQ ID NO:3 or the complement thereof.
6. An isolated nucleic acid molecule encoding the amino acid sequence described in SEQ ID
NO:8.
7. The isolated nucleic acid molecule of claim 6, wherein the molecule encodes the amino acid sequence of SEQ ID NO:6.
8. The isolated nucleic acid molecule of claim 7, wherein the molecule encodes the amino acid sequence of SEQ ID NO:4.
9. The isolated nucleic acid molecule of claim 8, wherein the molecule encodes the amino acid sequence of SEQ ID NO:2.
10. A substantially isolated protein having the activity of the protein shown in SEQ ID NOS:2, 4, 6, or 8, which is encoded by a nucleotide sequence that hybridizes to SEQ ID NO:1, 3, 5, or 7 under highly stringent conditions.
CA2448347A 2001-05-29 2002-05-23 Novel human hydroxylases and polynucleotides encoding the same Expired - Lifetime CA2448347C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US29407601P 2001-05-29 2001-05-29
US60/294,076 2001-05-29
PCT/US2002/016635 WO2002097039A2 (en) 2001-05-29 2002-05-23 Novel human hydroxylases and polynucleotides encoding the same

Publications (2)

Publication Number Publication Date
CA2448347A1 true CA2448347A1 (en) 2002-12-05
CA2448347C CA2448347C (en) 2010-09-21

Family

ID=23131776

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2448347A Expired - Lifetime CA2448347C (en) 2001-05-29 2002-05-23 Novel human hydroxylases and polynucleotides encoding the same

Country Status (8)

Country Link
US (2) US6867025B2 (en)
EP (1) EP1461425B1 (en)
JP (1) JP2005500829A (en)
AT (1) ATE386109T1 (en)
AU (1) AU2002303879B2 (en)
CA (1) CA2448347C (en)
DE (1) DE60225064T2 (en)
WO (1) WO2002097039A2 (en)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE10232151A1 (en) * 2002-07-16 2004-02-05 Max-Delbrück-Centrum für Molekulare Medizin Neuronically expressed tryptophan hydroxylase and its use
ZA200805192B (en) * 2005-12-29 2009-11-25 Lexicon Pharmaceuticals Inc Multicyclic amino acid derivatives and methods of their use
US9811188B1 (en) * 2014-12-23 2017-11-07 Amazon Technologies, Inc. Display stack
US11922756B2 (en) 2019-01-30 2024-03-05 J.J. Mackay Canada Limited Parking meter having touchscreen display
CA3031936A1 (en) 2019-01-30 2020-07-30 J.J. Mackay Canada Limited Spi keyboard module for a parking meter and a parking meter having an spi keyboard module

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US4215051A (en) 1979-08-29 1980-07-29 Standard Oil Company (Indiana) Formation, purification and recovery of phthalic anhydride
US4376110A (en) 1980-08-04 1983-03-08 Hybritech, Incorporated Immunometric assays using monoclonal antibodies
US4873191A (en) 1981-06-12 1989-10-10 Ohio University Genetic transformation of zygotes
DE3301833A1 (en) 1983-01-20 1984-07-26 Gesellschaft für Biotechnologische Forschung mbH (GBF), 3300 Braunschweig METHOD FOR SIMULTANEOUS SYNTHESIS OF SEVERAL OLIGONOCLEOTIDES IN A SOLID PHASE
US4713326A (en) 1983-07-05 1987-12-15 Molecular Diagnostics, Inc. Coupling of nucleic acids to solid support by photochemical methods
US4594595A (en) 1984-04-18 1986-06-10 Sanders Associates, Inc. Circular log-periodic direction-finder array
US4631211A (en) 1985-03-25 1986-12-23 Scripps Clinic & Research Foundation Means for sequential solid phase organic synthesis and methods using the same
DE3546807C2 (en) 1985-03-30 1991-03-28 Marc Genf/Geneve Ch Ballivet
US4946778A (en) 1987-09-21 1990-08-07 Genex Corporation Single polypeptide chain binding molecules
US5700637A (en) 1988-05-03 1997-12-23 Isis Innovation Limited Apparatus and method for analyzing polynucleotide sequences and method of generating oligonucleotide arrays
US5272057A (en) 1988-10-14 1993-12-21 Georgetown University Method of detecting a predisposition to cancer by the use of restriction fragment length polymorphism of the gene for human poly (ADP-ribose) polymerase
US5424186A (en) 1989-06-07 1995-06-13 Affymax Technologies N.V. Very large scale immobilized polymer synthesis
US5744101A (en) 1989-06-07 1998-04-28 Affymax Technologies N.V. Photolabile nucleoside protecting groups
US5143854A (en) 1989-06-07 1992-09-01 Affymax Technologies N.V. Large scale photolithographic solid phase synthesis of polypeptides and receptor binding screening thereof
US5252743A (en) 1989-11-13 1993-10-12 Affymax Technologies N.V. Spatially-addressable immobilization of anti-ligands on surfaces
EP1690935A3 (en) 1990-01-12 2008-07-30 Abgenix, Inc. Generation of xenogeneic antibodies
US6150584A (en) 1990-01-12 2000-11-21 Abgenix, Inc. Human antibodies derived from immunized xenomice
US6075181A (en) 1990-01-12 2000-06-13 Abgenix, Inc. Human antibodies derived from immunized xenomice
US5264618A (en) 1990-04-19 1993-11-23 Vical, Inc. Cationic lipids for intracellular delivery of biologically active molecules
US5877397A (en) 1990-08-29 1999-03-02 Genpharm International Inc. Transgenic non-human animals capable of producing heterologous antibodies of various isotypes
US6048850A (en) 1992-09-22 2000-04-11 Young; Donald A. Method of inhibiting prostaglandin synthesis in a human host
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US5908635A (en) 1994-08-05 1999-06-01 The United States Of America As Represented By The Department Of Health And Human Services Method for the liposomal delivery of nucleic acids
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US5948767A (en) 1994-12-09 1999-09-07 Genzyme Corporation Cationic amphiphile/DNA complexes

Also Published As

Publication number Publication date
AU2002303879B2 (en) 2007-08-09
EP1461425A2 (en) 2004-09-29
DE60225064D1 (en) 2008-03-27
US6867025B2 (en) 2005-03-15
US20050176042A1 (en) 2005-08-11
WO2002097039A2 (en) 2002-12-05
DE60225064T2 (en) 2009-01-29
US7105325B2 (en) 2006-09-12
WO2002097039A3 (en) 2004-07-08
US20020192694A1 (en) 2002-12-19
EP1461425A4 (en) 2004-12-15
ATE386109T1 (en) 2008-03-15
EP1461425B1 (en) 2008-02-13
CA2448347C (en) 2010-09-21
AU2002303879B9 (en) 2002-12-09
JP2005500829A (en) 2005-01-13

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Effective date: 20220524