CA2443292A1 - Disposable vaginal cannula for the simultaneous administration of drugs in different forms - Google Patents
Disposable vaginal cannula for the simultaneous administration of drugs in different forms Download PDFInfo
- Publication number
- CA2443292A1 CA2443292A1 CA002443292A CA2443292A CA2443292A1 CA 2443292 A1 CA2443292 A1 CA 2443292A1 CA 002443292 A CA002443292 A CA 002443292A CA 2443292 A CA2443292 A CA 2443292A CA 2443292 A1 CA2443292 A1 CA 2443292A1
- Authority
- CA
- Canada
- Prior art keywords
- cannula
- designed
- product
- separator
- plunger
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M31/00—Devices for introducing or retaining media, e.g. remedies, in cavities of the body
- A61M31/007—Injectors for solid bodies, e.g. suppositories
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M31/00—Devices for introducing or retaining media, e.g. remedies, in cavities of the body
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2210/00—Anatomical parts of the body
- A61M2210/14—Female reproductive, genital organs
- A61M2210/1475—Vagina
Abstract
This invention relates to a vaginal cannula which allows drugs of different physical forms, such as gel and a tablet, which must remain separate until the time of use, to be introduced into the vagina simultaneously. The instrument in accordance with the invention consists of a vaginal cannula (1), the distal part of which contains a separator (3) which separates the substances to be delivered and is configured in such a way that it also expels a tablet (5). A
plunger (2) inserted in the proximal part of the cannula compresses the gel (4) contained in the cannula, causing it to exit through a set of holes in the cannula wall in a suitable position. The subsequent travel of the plunger after expulsion of the gel causes it to engage with a separator/ejector system (3) so as to push the separator against a tablet housed in the anterior extremity of the cannula and expel it directly into the vagina.
plunger (2) inserted in the proximal part of the cannula compresses the gel (4) contained in the cannula, causing it to exit through a set of holes in the cannula wall in a suitable position. The subsequent travel of the plunger after expulsion of the gel causes it to engage with a separator/ejector system (3) so as to push the separator against a tablet housed in the anterior extremity of the cannula and expel it directly into the vagina.
Description
21-02-2003 CA 02443292 2003-10-02 . ~IT020021 ' ~ ~
WO 021081008 P'CT/ITU?JOOZ0.1 Dxs~eosA$~E vAGxNAL c.A,NroULA. FoR x~E
SIIYXUY.TANEOUS ADIVxINISTRATION O DRUCxS IN
DIFI'l;R.~NT F4R~S
This invention relates to a device, in p<<rticular a diisposable plastic eannula, which enables two drugs presented in different physical forms, in pa~rticnlar a geI and a tablet and/or powder, to be delivered into the vagina simultaneously.
The cannula has a particular configuration whitch enables it to keep the two products constantly separate at the time of packaging and during storage, until the time of use, to prevent deterioration of one or both substances, such as the vaginal tablet, ~v~rhich must not be xeh.~drated before use, because xehydration causes loss of its therapeutic efficac~~ or deterioration in its acti~~e components.
The cannula in accordance with the invention is particularly practical to use, because the two products axe ejected directly into the vagina almost sinnultaneously with a simple rnianoeuvre.
Various types of cannula already exist which enable a drug, a douching T 5 . fluid or the like to be introduced into the vagina.
For example, devices exist which consist of a small plastic ;reservoir connecfied to a cailnula containing a set of holes i~n the end through which the product is expelled.
When the cannula is fully screwed onto We body of the container, the end ~of the cannula perforates a closing wall, thm allowing expulsion of the product, performed by manually compressing th:e container, which acts as a pump. ,, ~Q
a ~ ~ 9V s "" ~ ~~G
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W m~~rr~ arc c~uGC~ ftll a C OCI
AMENDED SHEET
US A 4.341.211 xelates to a device for placing a suppository into a body cavi ty comprising:
- an applicator cylindrical body with a shaft extending from a first open end to a second open-end;
- a comparttx~ent or annular charatber surrounding said cylindrical body and filled with a lubricating substance, the wall of said annular chamber having a pluxality of openings which are open to the exterior; ~ ' - a lubricating plunger sized and shaped to fit 'within said compartment or annular chamber; and - a suppository plunger, sized and shaped to fit rvithin said cylindrical body, wherein said suppository plunger, which may mush said suppository from said first open end to and out of said second open end when said device is utilized, whereby when said device is placed r~ithin said body cavity, said suppository may be pushed through said second open end into said body cavity.
USA 4.439.184 descn'bes a syri~age for delivering tw>> separaxed bodies of fluid for use in preparing the urhetra for the insertion of a catheter, comprising:
- . a first piston for separatixtg the two bodies of fluid; ' .. a second piston for pushing the two bodies of.fluid out of the syringe; and - a fluid chamber having a no-pass zone in vvhi~~h khe pistons can slide and which has a cross section that each of the pistons substantially Ells, preventing the passing of fluid around the pistons when they are in the no-pass zone, an output zone to direct fluid push~;d out of the syringe by tire pistons, and a bypass zone, for receiving the furst piston, which connects the no-pass and o~xtput zones az~d which has si cross section that the first piston is unable to fill, so that when the first piston enters the bypass none tk~.e fluid between the f rst and second piston can pass around the first piston to the output zone.
Gm~~, AMENDED SHEET
nun 21-02-2003 CA 02443292 2003-10-02 , ' IT020021 b wo oa~osioos pc~rrrroznozo~
WO 021081008 P'CT/ITU?JOOZ0.1 Dxs~eosA$~E vAGxNAL c.A,NroULA. FoR x~E
SIIYXUY.TANEOUS ADIVxINISTRATION O DRUCxS IN
DIFI'l;R.~NT F4R~S
This invention relates to a device, in p<<rticular a diisposable plastic eannula, which enables two drugs presented in different physical forms, in pa~rticnlar a geI and a tablet and/or powder, to be delivered into the vagina simultaneously.
The cannula has a particular configuration whitch enables it to keep the two products constantly separate at the time of packaging and during storage, until the time of use, to prevent deterioration of one or both substances, such as the vaginal tablet, ~v~rhich must not be xeh.~drated before use, because xehydration causes loss of its therapeutic efficac~~ or deterioration in its acti~~e components.
The cannula in accordance with the invention is particularly practical to use, because the two products axe ejected directly into the vagina almost sinnultaneously with a simple rnianoeuvre.
Various types of cannula already exist which enable a drug, a douching T 5 . fluid or the like to be introduced into the vagina.
For example, devices exist which consist of a small plastic ;reservoir connecfied to a cailnula containing a set of holes i~n the end through which the product is expelled.
When the cannula is fully screwed onto We body of the container, the end ~of the cannula perforates a closing wall, thm allowing expulsion of the product, performed by manually compressing th:e container, which acts as a pump. ,, ~Q
a ~ ~ 9V s "" ~ ~~G
,. _~ _ ~L_ _a~~
W m~~rr~ arc c~uGC~ ftll a C OCI
AMENDED SHEET
US A 4.341.211 xelates to a device for placing a suppository into a body cavi ty comprising:
- an applicator cylindrical body with a shaft extending from a first open end to a second open-end;
- a comparttx~ent or annular charatber surrounding said cylindrical body and filled with a lubricating substance, the wall of said annular chamber having a pluxality of openings which are open to the exterior; ~ ' - a lubricating plunger sized and shaped to fit 'within said compartment or annular chamber; and - a suppository plunger, sized and shaped to fit rvithin said cylindrical body, wherein said suppository plunger, which may mush said suppository from said first open end to and out of said second open end when said device is utilized, whereby when said device is placed r~ithin said body cavity, said suppository may be pushed through said second open end into said body cavity.
USA 4.439.184 descn'bes a syri~age for delivering tw>> separaxed bodies of fluid for use in preparing the urhetra for the insertion of a catheter, comprising:
- . a first piston for separatixtg the two bodies of fluid; ' .. a second piston for pushing the two bodies of.fluid out of the syringe; and - a fluid chamber having a no-pass zone in vvhi~~h khe pistons can slide and which has a cross section that each of the pistons substantially Ells, preventing the passing of fluid around the pistons when they are in the no-pass zone, an output zone to direct fluid push~;d out of the syringe by tire pistons, and a bypass zone, for receiving the furst piston, which connects the no-pass and o~xtput zones az~d which has si cross section that the first piston is unable to fill, so that when the first piston enters the bypass none tk~.e fluid between the f rst and second piston can pass around the first piston to the output zone.
Gm~~, AMENDED SHEET
nun 21-02-2003 CA 02443292 2003-10-02 , ' IT020021 b wo oa~osioos pc~rrrroznozo~
..
The present invention falls into this sector, being designed to solve the problem of ' administering two products simultaneously, and keeping the said products completely separate until the time of use. The said products may both . be semi-solid products; alternatively, as in the case which will be illustrated herein is detail, one product may be in geI foam and the other in tablet form.
. Fox this purpose, the invention comprises a cannula fitted at the anterior extremity with a seating designed to house a tablet, a separator able to slide inside the caunula and fitted with means designs;d to engage the said tablet, a set of holes in a section of the cannula wall upstzeam of the separator, to allow expulsion of the gel contained in the cannula, and a plunger which expels tha gel dozing the first pant of its travel and subsequently engages the separator, causing it to engage with and expel the tablet.
This invenfiion will now be described in detail, by way of example but not of lix~rxxtation, by reference to the annexed figures in which:
~ figure 1 shows a cross-section of a oann~ula in accoxdauce with the invention before use, with the packaged product ~ $gure 2 shows a caxmula sheath which acts as the packaging of the product , ZO ~ . figure 3 shows a cross-section of a canaula in accordance with the invention after expulsion of the products ~ figure 4 is a perspective view of the caranula ~ accordance with the invention ~ :~guare 5 shows a cross-section of a further preferred embodiment of the cannula in accordance with the invention.
A.s shown in the anaexed figures, the caxmula in accordance with the invention comprises a bararel I which is open at both ends and fitted on one side (the proximal end) with a pair of wings or the Iike 2, and on the opposite side (the distal end) with a collar of smaller diameter, shown as 3, which surrounds the aperture of the cannula.
On the inner wall of barrel 1 there are three facing ridges shown as nos.
The present invention falls into this sector, being designed to solve the problem of ' administering two products simultaneously, and keeping the said products completely separate until the time of use. The said products may both . be semi-solid products; alternatively, as in the case which will be illustrated herein is detail, one product may be in geI foam and the other in tablet form.
. Fox this purpose, the invention comprises a cannula fitted at the anterior extremity with a seating designed to house a tablet, a separator able to slide inside the caunula and fitted with means designs;d to engage the said tablet, a set of holes in a section of the cannula wall upstzeam of the separator, to allow expulsion of the gel contained in the cannula, and a plunger which expels tha gel dozing the first pant of its travel and subsequently engages the separator, causing it to engage with and expel the tablet.
This invenfiion will now be described in detail, by way of example but not of lix~rxxtation, by reference to the annexed figures in which:
~ figure 1 shows a cross-section of a oann~ula in accoxdauce with the invention before use, with the packaged product ~ $gure 2 shows a caxmula sheath which acts as the packaging of the product , ZO ~ . figure 3 shows a cross-section of a canaula in accordance with the invention after expulsion of the products ~ figure 4 is a perspective view of the caranula ~ accordance with the invention ~ :~guare 5 shows a cross-section of a further preferred embodiment of the cannula in accordance with the invention.
A.s shown in the anaexed figures, the caxmula in accordance with the invention comprises a bararel I which is open at both ends and fitted on one side (the proximal end) with a pair of wings or the Iike 2, and on the opposite side (the distal end) with a collar of smaller diameter, shown as 3, which surrounds the aperture of the cannula.
On the inner wall of barrel 1 there are three facing ridges shown as nos.
4, 5 and 6 which are designed to engage a plunger 7, a separator/ejector element $, and a tablet 9, destined to be introduced into the vagina, respectively.
Plunger 7, which slides tightly inside barrel 1, could contain a ring-shaped groove 10 which engages with ridges 4 (or a corresponding raised ring) to retain the plunger and the plunger rod 11 in position before use of the cannula.
Separator 8 consists of a substantially cylindrical body which forms a seal against the inner wall of the cannula and in its anterior part has a cylindrical section 12 of smaller diameter, especially a diameter substantially corresponding to the inner diameter of collar 3.
The length of section 12 is substantially equal to the length of collar 3, so that when separator 8 is in contact with the distal closing wall of the cannula (position illustrated in figure 3), cylindrical body 12 does not project from the cannula.
The body of separator 8 too, will preferably have a ring-shaped groove designed to engage with ridges 5.
In accordance with the invention, the wall of barrel 1 presents a plurality of holes 13 distributed along a length of wall immediately upstream of separator 8, in correspondence with the distal end. These holes allow the expulsion of a semi-solid product, for example a drug or a pharmaceutically acceptable carrier in the form of a gel 14, contained in the cannula.
A second section of cannula wall, upstream of the preceding one, presents a set of holes 15 through which air is expelled from the cannula during the stage of filling the cannula with the drug in gel form, so that plunger 7 can slide until it comes into contact with the gel without any air being trapped.
The cannula is completed by a sheath 16 which acts as the packaging for the product and at the time prevents the gel from leaking out of expulsion holes 13 of the cannula during the filling stage.
The dimensions of the cannula can vary, depending on the material to be delivered, although for most applications its length could be approx. 12 centimetres and its diameter approx. 12-14 mm.
In order to prepare the cannula containing the product, the separator is first inserted into the barrel until it engages with the corresponding ridge 5, which retains it at a distance from the distal end of the cannula, in the position shown in figure 1.
Next, the tablet is introduced by inserting it into collar 3, where it is retained by ridges 6.
Sheath 16 is then fitted over the cannula so as to close the end containing the tablet and cover the entire length containing holes 13.
Next, the required amount of gel is introduced into the cannula, in contact with separator 8, and plunger 7 is inserted and pushed in until it comes into contact with the gel.
The plunger, which is made of plastic suitable for the purpose, slides tightly along the inner wall of the barrel, as in the case of a syringe.
In order to use the cannula it is sufficient to remove sheath 16, hold the cannula by wings 2, and press on rod 11 of plunger 7, which is forced to advance into the cannula.
The thrust exerted by plunger 7 first forces out gel 14 through holes 13 in the cannula wall.
When the plunger has pushed all of the gel out of the cannula, it will come into contact with separator/ejector system 8.
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'1-02-2003 ~~C~. ~ IT0200204 w0 o2I08i008 ' ~ pCTIlTOa~ao2p~
The subsequent advance of the plunger will force the separator out of itts seating, pushing it forward until cylindrical body 12 penetrates into collar 3,.
removing arid expelling vaginal tablet 9, which ~is thus deposited in. the vagina.
At this point, separator 8 engages with anterior wall. of tlae cannula, 5 preventing it from advancing further.
The dimensions of ridges 4, S and 6, attd especially those of ridge S, which retains separator S in position, will be vhosen according to the characteristics of the gel, in such a way that the force required to xaove the separator is greater than *hat needed to expel the: gel.
As will clearly appear from the, description supplied, the canzaula in aceorda~aee witb~ the invention is particularly coavenieut and practical, since it aZl.ows the delivery a~ two products W th different physical characteristics;
such as a pxoduct.in. gel form and a solid product in tablet form.
illustrated in figure S, the anterior extremity o:f the cr. cold be closed, cad separator 8 could cat as a parti ' I"~be~tween two consecutive lengths of the cannula s ' s 18 and 1 ~, which could be ~ filled iwith tvvo different The carinula could also be used to deliver different products for .
different ' clinical applications, including, by way of example but not of limitation, the following:
1 - Acidifying gel ar~td vaginal tablet based oi~ Lactobacillus acidophitus to rebalance the vaginal ecosystem.
2 - Acidifying gel and metronidazole tablet to beat vaginitis caused by 2S Gardr~erella vaginadis and f'riehomortas and simultaneously restore filie normal vaginal ecosystem.
3 - Gel with a slightly acid pH and ' autifungal vaginal tablets to treat fungal vaginitis axed provide a soothing effect on the damaged mucosa. .
Ea~pf a AMENDED SHEET
~.
Plunger 7, which slides tightly inside barrel 1, could contain a ring-shaped groove 10 which engages with ridges 4 (or a corresponding raised ring) to retain the plunger and the plunger rod 11 in position before use of the cannula.
Separator 8 consists of a substantially cylindrical body which forms a seal against the inner wall of the cannula and in its anterior part has a cylindrical section 12 of smaller diameter, especially a diameter substantially corresponding to the inner diameter of collar 3.
The length of section 12 is substantially equal to the length of collar 3, so that when separator 8 is in contact with the distal closing wall of the cannula (position illustrated in figure 3), cylindrical body 12 does not project from the cannula.
The body of separator 8 too, will preferably have a ring-shaped groove designed to engage with ridges 5.
In accordance with the invention, the wall of barrel 1 presents a plurality of holes 13 distributed along a length of wall immediately upstream of separator 8, in correspondence with the distal end. These holes allow the expulsion of a semi-solid product, for example a drug or a pharmaceutically acceptable carrier in the form of a gel 14, contained in the cannula.
A second section of cannula wall, upstream of the preceding one, presents a set of holes 15 through which air is expelled from the cannula during the stage of filling the cannula with the drug in gel form, so that plunger 7 can slide until it comes into contact with the gel without any air being trapped.
The cannula is completed by a sheath 16 which acts as the packaging for the product and at the time prevents the gel from leaking out of expulsion holes 13 of the cannula during the filling stage.
The dimensions of the cannula can vary, depending on the material to be delivered, although for most applications its length could be approx. 12 centimetres and its diameter approx. 12-14 mm.
In order to prepare the cannula containing the product, the separator is first inserted into the barrel until it engages with the corresponding ridge 5, which retains it at a distance from the distal end of the cannula, in the position shown in figure 1.
Next, the tablet is introduced by inserting it into collar 3, where it is retained by ridges 6.
Sheath 16 is then fitted over the cannula so as to close the end containing the tablet and cover the entire length containing holes 13.
Next, the required amount of gel is introduced into the cannula, in contact with separator 8, and plunger 7 is inserted and pushed in until it comes into contact with the gel.
The plunger, which is made of plastic suitable for the purpose, slides tightly along the inner wall of the barrel, as in the case of a syringe.
In order to use the cannula it is sufficient to remove sheath 16, hold the cannula by wings 2, and press on rod 11 of plunger 7, which is forced to advance into the cannula.
The thrust exerted by plunger 7 first forces out gel 14 through holes 13 in the cannula wall.
When the plunger has pushed all of the gel out of the cannula, it will come into contact with separator/ejector system 8.
~hflQ
'1-02-2003 ~~C~. ~ IT0200204 w0 o2I08i008 ' ~ pCTIlTOa~ao2p~
The subsequent advance of the plunger will force the separator out of itts seating, pushing it forward until cylindrical body 12 penetrates into collar 3,.
removing arid expelling vaginal tablet 9, which ~is thus deposited in. the vagina.
At this point, separator 8 engages with anterior wall. of tlae cannula, 5 preventing it from advancing further.
The dimensions of ridges 4, S and 6, attd especially those of ridge S, which retains separator S in position, will be vhosen according to the characteristics of the gel, in such a way that the force required to xaove the separator is greater than *hat needed to expel the: gel.
As will clearly appear from the, description supplied, the canzaula in aceorda~aee witb~ the invention is particularly coavenieut and practical, since it aZl.ows the delivery a~ two products W th different physical characteristics;
such as a pxoduct.in. gel form and a solid product in tablet form.
illustrated in figure S, the anterior extremity o:f the cr. cold be closed, cad separator 8 could cat as a parti ' I"~be~tween two consecutive lengths of the cannula s ' s 18 and 1 ~, which could be ~ filled iwith tvvo different The carinula could also be used to deliver different products for .
different ' clinical applications, including, by way of example but not of limitation, the following:
1 - Acidifying gel ar~td vaginal tablet based oi~ Lactobacillus acidophitus to rebalance the vaginal ecosystem.
2 - Acidifying gel and metronidazole tablet to beat vaginitis caused by 2S Gardr~erella vaginadis and f'riehomortas and simultaneously restore filie normal vaginal ecosystem.
3 - Gel with a slightly acid pH and ' autifungal vaginal tablets to treat fungal vaginitis axed provide a soothing effect on the damaged mucosa. .
Ea~pf a AMENDED SHEET
~.
4 - Acidifying gel and antibiotic tablets such as meclocycline to treat bacterial vaginitis and rebalance the vaginal ecosystem.
- Oestradiol hormone gel and Lactobacillus acidophilus vaginal tablet for topical treatment of the menopause and dystrophic forms, and restoration of 5 the normal vaginal ecosystem.
- Oestradiol hormone gel and Lactobacillus acidophilus vaginal tablet for topical treatment of the menopause and dystrophic forms, and restoration of 5 the normal vaginal ecosystem.
Claims (6)
1. Disposable vaginal cannula designed to deliver drugs with different compositions simultaneously, comprising means (1, 3) designed to receive two or more different products to be administered and means (7) designed to expel the said products simultaneously or successively, characterised in that:
- said means (1, 3) designed to receive two or more different products consist of a barrel (1) defining a single cylindrical chamber designed to contain a dose of a first product (14), said chamber having a plurality of holes (13) in the wall of the said barrel (1), in correspondence with the distal section of the cannula, to allow the exit if the said first product.(74), and an opening in the anterior wall of the cannula provided with means (3) designed to receive and retain a second medical product (9);
- means (7) designed to expel the said products consist of a plunger (7) designed to press on the said product to control its expulsion;
- a sealed separator (8) being provided, inserted into said chamber in the cannula downstream of the said first product (14), said separator (8) sliding inside the cannula and having means (12) designed to engage the second product to control its expulsion.
- said means (1, 3) designed to receive two or more different products consist of a barrel (1) defining a single cylindrical chamber designed to contain a dose of a first product (14), said chamber having a plurality of holes (13) in the wall of the said barrel (1), in correspondence with the distal section of the cannula, to allow the exit if the said first product.(74), and an opening in the anterior wall of the cannula provided with means (3) designed to receive and retain a second medical product (9);
- means (7) designed to expel the said products consist of a plunger (7) designed to press on the said product to control its expulsion;
- a sealed separator (8) being provided, inserted into said chamber in the cannula downstream of the said first product (14), said separator (8) sliding inside the cannula and having means (12) designed to engage the second product to control its expulsion.
2. Cannula as claimed in claim 1, characterised in that it is provided with a covering sheath (16) designed to be fitted over the distal end of the cannula, which said sheath covers at least the length of cannula containing the said openings (3, 13) for the exit of the product.
3. Vaginal cannula as claimed in each of the preceding claims, characterised in that the inner wall of the said cannula presents ridges (5) designed to retain the said separator in position.
4. Cannula as claimed in claim 1, characterised in that the inner surface of the cannula presents ridges (6) designed to retain the second product in position.
5. Cannula as claimed in claim 1, characterised in that the inner surface of the cannula presents means (4) designed to retain plunger (7), which controls the expulsion of the product, in position prior to use.
6. Cannula as claimed in each of the preceding claims, characterised in that the wall of the cannula upstream of the section containing the fist product contains a series of holes (15) designed to allow the exit of air when plunger (7) is introduced into the cannula.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IT2001FO000010A ITFO20010010A1 (en) | 2001-04-05 | 2001-04-05 | DISPOSABLE VAGINAL CANNULA TOOL FOR SIMULTANEOUS VEHICULATION OF DIFFERENT MOLECULAR FORM DRUGS (GEL AND TABS) SEP PACKED |
| ITFO2001A000010 | 2001-04-05 | ||
| PCT/IT2002/000204 WO2002081008A1 (en) | 2001-04-05 | 2002-04-02 | Disposable vaginal cannula for the simultaneous administration of drugs in different forms |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA2443292A1 true CA2443292A1 (en) | 2002-10-17 |
Family
ID=11442413
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002443292A Abandoned CA2443292A1 (en) | 2001-04-05 | 2002-04-02 | Disposable vaginal cannula for the simultaneous administration of drugs in different forms |
Country Status (19)
| Country | Link |
|---|---|
| US (1) | US20040092906A1 (en) |
| EP (1) | EP1372761B1 (en) |
| JP (1) | JP2004524925A (en) |
| CN (1) | CN1247270C (en) |
| AT (1) | ATE311212T1 (en) |
| BR (1) | BR0208638A (en) |
| CA (1) | CA2443292A1 (en) |
| CZ (1) | CZ20032674A3 (en) |
| DE (1) | DE60207693T2 (en) |
| ES (1) | ES2254677T3 (en) |
| HU (1) | HUP0303597A3 (en) |
| IL (1) | IL158216A0 (en) |
| IT (1) | ITFO20010010A1 (en) |
| MX (1) | MXPA03009022A (en) |
| NO (1) | NO20034417L (en) |
| PL (1) | PL369121A1 (en) |
| RU (1) | RU2288744C2 (en) |
| SK (1) | SK12242003A3 (en) |
| WO (1) | WO2002081008A1 (en) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7520862B2 (en) * | 2004-02-03 | 2009-04-21 | Neuro Diagnostic Devices, Inc. | Cerebral spinal fluid shunt evaluation system |
| CA2602588A1 (en) * | 2005-03-31 | 2006-10-05 | Johnson & Johnson Consumers Companies, Inc. | Lubricated tampon applicator |
| US8308678B2 (en) * | 2008-09-23 | 2012-11-13 | Mcneil-Ppc, Inc. | Pre-filled applicator device |
| DE102010015350A1 (en) * | 2010-04-16 | 2011-10-20 | Michael Zimmermann | vaginal applicator |
| WO2013113767A1 (en) * | 2012-01-31 | 2013-08-08 | Bioclin Bv | Method for administration of a probiotic |
| CN106725264A (en) * | 2017-02-23 | 2017-05-31 | 张淑霞 | A kind of gynemetrics's clinic detects treatment integrated apparatus |
| ES2685048B1 (en) * | 2017-03-31 | 2019-07-16 | Martinez Moraleda Rocio | Single-dose and disposable preloaded device for the application of products in the vagina or rectal cavity |
| CN109350833A (en) * | 2018-11-23 | 2019-02-19 | 王倩倩 | A kind of gynecopathy therapeutic cartridge syringe |
| US11439803B2 (en) | 2019-01-31 | 2022-09-13 | Niva Medtech LLC | Medicant applicator |
| USD908211S1 (en) | 2020-01-31 | 2021-01-19 | Niva Medtech LLC | Medicant applicator |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4341211A (en) * | 1981-09-08 | 1982-07-27 | Kline Larry H | Lubricating object applicator |
| US4421504A (en) * | 1981-09-08 | 1983-12-20 | Kline Larry H | Lubricating object injector utilizing a single plunger |
| AU545171B2 (en) * | 1981-12-09 | 1985-07-04 | Alcide Corporation | Germicidal chlorine dioxide-forming compositions |
| US4439184A (en) * | 1982-05-03 | 1984-03-27 | Concord Laboratories, Inc. | Two-dose syringe |
| AU677612B2 (en) * | 1992-12-31 | 1997-05-01 | Mcneil-Ppc, Inc. | Environmentally friendly catamenial tampon assembly and method of construction |
-
2001
- 2001-04-05 IT IT2001FO000010A patent/ITFO20010010A1/en unknown
-
2002
- 2002-04-02 SK SK1224-2003A patent/SK12242003A3/en unknown
- 2002-04-02 AT AT02728017T patent/ATE311212T1/en not_active IP Right Cessation
- 2002-04-02 CN CN02807783.0A patent/CN1247270C/en not_active Expired - Fee Related
- 2002-04-02 DE DE60207693T patent/DE60207693T2/en not_active Expired - Fee Related
- 2002-04-02 ES ES02728017T patent/ES2254677T3/en not_active Expired - Lifetime
- 2002-04-02 HU HU0303597A patent/HUP0303597A3/en unknown
- 2002-04-02 BR BR0208638-7A patent/BR0208638A/en not_active IP Right Cessation
- 2002-04-02 RU RU2003129451/14A patent/RU2288744C2/en not_active IP Right Cessation
- 2002-04-02 IL IL15821602A patent/IL158216A0/en unknown
- 2002-04-02 EP EP02728017A patent/EP1372761B1/en not_active Expired - Lifetime
- 2002-04-02 CZ CZ20032674A patent/CZ20032674A3/en unknown
- 2002-04-02 JP JP2002579046A patent/JP2004524925A/en active Pending
- 2002-04-02 PL PL02369121A patent/PL369121A1/en unknown
- 2002-04-02 CA CA002443292A patent/CA2443292A1/en not_active Abandoned
- 2002-04-02 MX MXPA03009022A patent/MXPA03009022A/en active IP Right Grant
- 2002-04-02 WO PCT/IT2002/000204 patent/WO2002081008A1/en not_active Application Discontinuation
-
2003
- 2003-09-29 US US10/679,628 patent/US20040092906A1/en not_active Abandoned
- 2003-10-02 NO NO20034417A patent/NO20034417L/en not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| EP1372761A1 (en) | 2004-01-02 |
| US20040092906A1 (en) | 2004-05-13 |
| RU2003129451A (en) | 2005-03-27 |
| WO2002081008A1 (en) | 2002-10-17 |
| HUP0303597A2 (en) | 2004-01-28 |
| CZ20032674A3 (en) | 2004-03-17 |
| JP2004524925A (en) | 2004-08-19 |
| RU2288744C2 (en) | 2006-12-10 |
| HUP0303597A3 (en) | 2006-03-28 |
| CN1499986A (en) | 2004-05-26 |
| NO20034417D0 (en) | 2003-10-02 |
| EP1372761B1 (en) | 2005-11-30 |
| DE60207693D1 (en) | 2006-01-05 |
| ATE311212T1 (en) | 2005-12-15 |
| ITFO20010010A1 (en) | 2001-07-05 |
| PL369121A1 (en) | 2005-04-18 |
| MXPA03009022A (en) | 2004-10-15 |
| DE60207693T2 (en) | 2006-08-17 |
| CN1247270C (en) | 2006-03-29 |
| BR0208638A (en) | 2004-03-09 |
| SK12242003A3 (en) | 2004-05-04 |
| IL158216A0 (en) | 2004-05-12 |
| ES2254677T3 (en) | 2006-06-16 |
| NO20034417L (en) | 2003-12-03 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FZDE | Discontinued |