CA2442548A1 - High strength bioresorbables containing poly-glycolic acid - Google Patents
High strength bioresorbables containing poly-glycolic acid Download PDFInfo
- Publication number
- CA2442548A1 CA2442548A1 CA002442548A CA2442548A CA2442548A1 CA 2442548 A1 CA2442548 A1 CA 2442548A1 CA 002442548 A CA002442548 A CA 002442548A CA 2442548 A CA2442548 A CA 2442548A CA 2442548 A1 CA2442548 A1 CA 2442548A1
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- CA
- Canada
- Prior art keywords
- artefact
- poly
- polymer
- fibres
- process according
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Classifications
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- D—TEXTILES; PAPER
- D02—YARNS; MECHANICAL FINISHING OF YARNS OR ROPES; WARPING OR BEAMING
- D02J—FINISHING OR DRESSING OF FILAMENTS, YARNS, THREADS, CORDS, ROPES OR THE LIKE
- D02J1/00—Modifying the structure or properties resulting from a particular structure; Modifying, retaining, or restoring the physical form or cross-sectional shape, e.g. by use of dies or squeeze rollers
- D02J1/22—Stretching or tensioning, shrinking or relaxing, e.g. by use of overfeed and underfeed apparatus, or preventing stretch
- D02J1/228—Stretching in two or more steps, with or without intermediate steps
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L17/00—Materials for surgical sutures or for ligaturing blood vessels ; Materials for prostheses or catheters
- A61L17/06—At least partially resorbable materials
- A61L17/10—At least partially resorbable materials containing macromolecular materials
- A61L17/12—Homopolymers or copolymers of glycolic acid or lactic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
- A61L31/04—Macromolecular materials
- A61L31/06—Macromolecular materials obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
- C08G63/00—Macromolecular compounds obtained by reactions forming a carboxylic ester link in the main chain of the macromolecule
- C08G63/02—Polyesters derived from hydroxycarboxylic acids or from polycarboxylic acids and polyhydroxy compounds
- C08G63/06—Polyesters derived from hydroxycarboxylic acids or from polycarboxylic acids and polyhydroxy compounds derived from hydroxycarboxylic acids
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
- C08G63/00—Macromolecular compounds obtained by reactions forming a carboxylic ester link in the main chain of the macromolecule
- C08G63/02—Polyesters derived from hydroxycarboxylic acids or from polycarboxylic acids and polyhydroxy compounds
- C08G63/06—Polyesters derived from hydroxycarboxylic acids or from polycarboxylic acids and polyhydroxy compounds derived from hydroxycarboxylic acids
- C08G63/08—Lactones or lactides
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
- C08L67/00—Compositions of polyesters obtained by reactions forming a carboxylic ester link in the main chain; Compositions of derivatives of such polymers
- C08L67/04—Polyesters derived from hydroxycarboxylic acids, e.g. lactones
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Polymers & Plastics (AREA)
- Medicinal Chemistry (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Vascular Medicine (AREA)
- Surgery (AREA)
- Life Sciences & Earth Sciences (AREA)
- Materials Engineering (AREA)
- Textile Engineering (AREA)
- Heart & Thoracic Surgery (AREA)
- Materials For Medical Uses (AREA)
- Compositions Of Macromolecular Compounds (AREA)
- Biological Depolymerization Polymers (AREA)
- Artificial Filaments (AREA)
- Polyesters Or Polycarbonates (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Other Resins Obtained By Reactions Not Involving Carbon-To-Carbon Unsaturated Bonds (AREA)
- Polyamides (AREA)
- Reinforced Plastic Materials (AREA)
Abstract
Polymer compositions comprising poly-glycolic acid (PGA) or a functional derivative thereof with a tensile strength of at least 1200 MPa are disclosed.
Processes suitable for manufacturing said compositions are also described, comprising rendering PGA into an amorphous state then drawing to form a highly orientated polymer structure. The polymer compositions can be used to make artefacts, for example sutures, or used in combination with other polymers or non-polymeric substances to produce other artefacts, for example medical devices suitable for implantation into the human body. Processes for the production of said artefacts are also described.
Processes suitable for manufacturing said compositions are also described, comprising rendering PGA into an amorphous state then drawing to form a highly orientated polymer structure. The polymer compositions can be used to make artefacts, for example sutures, or used in combination with other polymers or non-polymeric substances to produce other artefacts, for example medical devices suitable for implantation into the human body. Processes for the production of said artefacts are also described.
Claims (28)
1. A polymer composition comprising poly-glycolic acid or a functional derivative thereof with a tensile strength of at least 1200MPa
2. A polymer composition of claim 1 formed into orientated fibres
3. A polymer composition of claims 1 to 2 where the fibres have a tensile modulus of at least 22GPa
4. A process for the manufacture of polymer compositions as claimed in claims 1 to 3 comprising increasing polymer chain orientation of a substantially amorphous polymer by drawing at localized points within the mass
5. A process for the manufacture of polymer compositions as claimed in any one of the preceding claims including the steps of forming poly-glycolic acid or a functional derivative thereof into fibres, quenching the fibres then subjecting the quenched fibres to a tension under conditions whereby a defined region of the tensioned fibres is drawn
6. A process according to claim 5 there the fibre-forming method is melt extrusion or solution spinning
7. A process according to claims 5 or 6 wherein the quenched, tensioned fibres are subjected to zone-heating
8. A process according to claims 5 to 7 wherein the quenched, tensioned fibres are subjected to at least two separate drawing steps, each drawing step performed under identical or different conditions
9. An artefact comprising poly-glycolic acid or a functional derivative thereof according to claims 1 to 3 or when produced by the process according to any one of claims 4 to 8
10. An artefact as claimed in claim 9 comprising at least two polymer components
11. An artefact according to claim 10 comprising 10% to 80% by volume poly-glycolic acid or a functional derivative thereof according to claims 1 to 3
12. An artefact of claims 10 or 11 wherein at least one of the polymer components is a co-polymer, or polymer blend
13. An artefact of claims 10 to 12 where at least one of the polymer components is bioresorbable
14. An artefact of claim 13 where the bioresorbable polymer comprises a poly-hydroxy acid, a poly-lactic acid, a poly-caprolactone, a poly-acetal or a poly-anhydride
15. An artefact of any of the preceding claims comprising at least one non-bioresorbable polymer component
16. An artefact of claim 15 where the non-bioresorbable polymer comprises poly-propylene, poly-ethylene, poly-methyl methacrylate or epoxy resin
17. An artefact of any of the preceding claims further containing at least one non-polymeric component
18. An artefact of claim 17 where the non-polymeric component comprises a ceramic, hydroxyapatite or tricalcium phosphate
19. An artefact of claims 17 or 18 where the non-polymeric component comprises a bioactive factor
20. An artefact of claim 19 where the bioactive component comprises a natural or engineered protein, a ribonucleic acid, a deoxyribonucleic acid, a growth factor, a cytokine, an angiogenic factor or an antibody
21. An artefact according to any of the preceding claims in the form of a medical device
22. An artefact of claim 21 where the device is a suture, a scaffold for tissue engineering or implantation, an orthopaedic implant, a complex shaped device or a bone fixation device
23. A process for the manufacture of artefacts according to claims 10 to 22 that further includes the step of compression moulding other polymeric, non-polymeric or blend of polymeric and non-polymeric components in the presence of said fibres
24. A process according to claims 10 to 23 further comprising forming a polymeric component in the presence of said fibres by in situ curing of monomers or other precursors for said polymeric component
25. A process according to claim 24 where the monomers used do not liberate a by-product on polymerization
26. A process according to claims 24 or 25 where at least one of the monomers is a ring-opening monomer that opens to form a poly-hydroxy acid
27. A process according to claims 24 to 26 where at least one monomer is a lactide, a glycolide, a caprolactone, a carbonate or mixtures thereof
28.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB0202233.3 | 2002-01-31 | ||
GBGB0202233.3A GB0202233D0 (en) | 2002-01-31 | 2002-01-31 | Bioresorbable polymers |
PCT/GB2003/000400 WO2003064531A1 (en) | 2002-01-31 | 2003-01-31 | High strength bioresorbables containing poly-glycolic acid |
Publications (2)
Publication Number | Publication Date |
---|---|
CA2442548A1 true CA2442548A1 (en) | 2003-08-07 |
CA2442548C CA2442548C (en) | 2012-11-20 |
Family
ID=9930119
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CA2442548A Expired - Fee Related CA2442548C (en) | 2002-01-31 | 2003-01-31 | High strength bioresorbables containing poly-glycolic acid |
Country Status (13)
Country | Link |
---|---|
US (1) | US7455674B2 (en) |
EP (1) | EP1470192B1 (en) |
JP (1) | JP2005516100A (en) |
CN (1) | CN100345904C (en) |
AT (1) | ATE439405T1 (en) |
AU (1) | AU2003239428B2 (en) |
CA (1) | CA2442548C (en) |
DE (1) | DE60328753D1 (en) |
ES (1) | ES2331415T3 (en) |
GB (1) | GB0202233D0 (en) |
IL (1) | IL158120A0 (en) |
NO (1) | NO20034359L (en) |
WO (1) | WO2003064531A1 (en) |
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EP1955726B1 (en) * | 2005-11-28 | 2012-04-18 | Japan Science and Technology Agency | Apparatus for producing the medical instrument to be placed in the body and method of producing the medical instrument to be placed in the body |
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-
2002
- 2002-01-31 GB GBGB0202233.3A patent/GB0202233D0/en not_active Ceased
-
2003
- 2003-01-31 AU AU2003239428A patent/AU2003239428B2/en not_active Ceased
- 2003-01-31 CA CA2442548A patent/CA2442548C/en not_active Expired - Fee Related
- 2003-01-31 JP JP2003564135A patent/JP2005516100A/en active Pending
- 2003-01-31 AT AT03734764T patent/ATE439405T1/en not_active IP Right Cessation
- 2003-01-31 ES ES03734764T patent/ES2331415T3/en not_active Expired - Lifetime
- 2003-01-31 CN CNB038003376A patent/CN100345904C/en not_active Expired - Fee Related
- 2003-01-31 IL IL15812003A patent/IL158120A0/en unknown
- 2003-01-31 WO PCT/GB2003/000400 patent/WO2003064531A1/en active Application Filing
- 2003-01-31 EP EP03734764A patent/EP1470192B1/en not_active Expired - Lifetime
- 2003-01-31 DE DE60328753T patent/DE60328753D1/en not_active Expired - Lifetime
- 2003-01-31 US US10/472,908 patent/US7455674B2/en not_active Expired - Fee Related
- 2003-09-29 NO NO20034359A patent/NO20034359L/en not_active Application Discontinuation
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CA2442548C (en) | 2012-11-20 |
US7455674B2 (en) | 2008-11-25 |
NO20034359L (en) | 2003-12-01 |
NO20034359D0 (en) | 2003-09-29 |
WO2003064531A1 (en) | 2003-08-07 |
CN100345904C (en) | 2007-10-31 |
ATE439405T1 (en) | 2009-08-15 |
US20040106734A1 (en) | 2004-06-03 |
DE60328753D1 (en) | 2009-09-24 |
JP2005516100A (en) | 2005-06-02 |
IL158120A0 (en) | 2004-03-28 |
AU2003239428B2 (en) | 2008-04-24 |
CN1537144A (en) | 2004-10-13 |
EP1470192A1 (en) | 2004-10-27 |
ES2331415T3 (en) | 2010-01-04 |
EP1470192B1 (en) | 2009-08-12 |
GB0202233D0 (en) | 2002-03-20 |
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