CA2441587A1 - Fluid filled ampoules and methods for their use in aerosolizers - Google Patents

Fluid filled ampoules and methods for their use in aerosolizers Download PDF

Info

Publication number
CA2441587A1
CA2441587A1 CA002441587A CA2441587A CA2441587A1 CA 2441587 A1 CA2441587 A1 CA 2441587A1 CA 002441587 A CA002441587 A CA 002441587A CA 2441587 A CA2441587 A CA 2441587A CA 2441587 A1 CA2441587 A1 CA 2441587A1
Authority
CA
Canada
Prior art keywords
ampoule
tab
aerosolization device
bottom end
keying element
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA002441587A
Other languages
French (fr)
Other versions
CA2441587C (en
Inventor
Joseph P. Loeffler
Richard Q. Poynter
David Rapp
Michael Klimowicz
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Novartis AG
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2441587A1 publication Critical patent/CA2441587A1/en
Application granted granted Critical
Publication of CA2441587C publication Critical patent/CA2441587C/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A61M15/0085—Inhalators using ultrasonics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/05—Containers specially adapted for medical or pharmaceutical purposes for collecting, storing or administering blood, plasma or medical fluids ; Infusion or perfusion containers
    • A61J1/06—Ampoules or carpules
    • A61J1/065—Rigid ampoules, e.g. glass ampoules
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A61M15/0028—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A61M15/0028—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up
    • A61M15/003—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up using capsules, e.g. to be perforated or broken-up
    • A61M15/0031—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up using capsules, e.g. to be perforated or broken-up by bursting or breaking the package, i.e. without cutting or piercing
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A61M15/009—Inhalators using medicine packages with incorporated spraying means, e.g. aerosol cans
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
    • B65D1/00—Containers having bodies formed in one piece, e.g. by casting metallic material, by moulding plastics, by blowing vitreous material, by throwing ceramic material, by moulding pulped fibrous material, by deep-drawing operations performed on sheet material
    • B65D1/09—Ampoules
    • B65D1/095—Ampoules made of flexible material
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J2205/00—General identification or selection means
    • A61J2205/10—Bar codes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J2205/00—General identification or selection means
    • A61J2205/60—General identification or selection means using magnetic or electronic identifications, e.g. chips, RFID, electronic tags
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00—General characteristics of the apparatus
    • A61M2205/60—General characteristics of the apparatus with identification means
    • A61M2205/6045—General characteristics of the apparatus with identification means having complementary physical shapes for indexing or registration purposes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00—General characteristics of the apparatus
    • A61M2205/60—General characteristics of the apparatus with identification means
    • A61M2205/6054—Magnetic identification systems
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B05—SPRAYING OR ATOMISING IN GENERAL; APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
    • B05B—SPRAYING APPARATUS; ATOMISING APPARATUS; NOZZLES
    • B05B17/00—Apparatus for spraying or atomising liquids or other fluent materials, not covered by the preceding groups
    • B05B17/04—Apparatus for spraying or atomising liquids or other fluent materials, not covered by the preceding groups operating with special methods
    • B05B17/06—Apparatus for spraying or atomising liquids or other fluent materials, not covered by the preceding groups operating with special methods using ultrasonic or other kinds of vibrations
    • B05B17/0607—Apparatus for spraying or atomising liquids or other fluent materials, not covered by the preceding groups operating with special methods using ultrasonic or other kinds of vibrations generated by electrical means, e.g. piezoelectric transducers
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
    • B65D2203/00—Decoration means, markings, information elements, contents indicators
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S206/00—Special receptacle or package
    • Y10S206/828—Medicinal content
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S215/00—Bottles and jars
    • Y10S215/03—Medical

Abstract

An ampoule (10) designed for holding fluid and adapted for use in an aerosolization device having two opposing ends (14 & 16) and a sealed in terior (18). One end (14) having a movable shroud (24) and removable tab (22) for creating a drain vent and an opposing end (16) having a removable tab (30) f or to create a drain vent.

Claims (39)

1. 1. A fluid filled ampoule, comprising:
an ampoule body having a top end, a bottom end, and a sealed interior containing a liquid;
a top tab that is coupled to the top end, wherein the top tab is removable to create a drain vent in the top end;
a bottom tab that is coupled to the bottom end, wherein the bottom tab is removable to create a drain opening in the bottom end; and a movable shroud that is coupled to the top end and which is disposed about the top tab.
2. An ampoule as in claim 1, wherein the top tab and the bottom tab are coupled to the ampoule body such that they are removable by applying a twisting action.
3. An ampoule as in claim 1, wherein the shroud is bendable to provide access to the top tab.
4. An ampoule as in claim 1, further comprising a pair of longitudinal rails on the ampoule body that are adapted to guide the ampoule into a receiver of an aerosolization device.
5. An ampoule as in claim 4, wherein the rails have different sizes so that the ampoule may be inserted into the receiver in only one orientation.
6. An ampoule as in claim 1, wherein the bottom end is tapered to provide a surface area at the bottom end that is adapted to provide a seal with a receiver of an aerosolization device.
7. An ampoule as in claim 1, wherein the ampoule body has a wall thickness of at least about 0.03 inch.
8. An ampoule as in claim 1, further comprising at least one keying element on the ampoule body that is adapted to permit operation of an aerosolization device when the keying element is accepted by the aerosolization device.
9. An ampoule as in claim 8, wherein the keying element comprises a protrusion extending from the ampoule body.
10. An ampoule as in claim 8, wherein the keying element comprises a readable pattern on the ampoule body.
11. A fluid filled ampoule, comprising:
an ampoule body having a top end, a bottom end, and a sealed interior containing a liquid, wherein the top end and the bottom end are each adapted to be opened to provide respective vent and drain openings; and at least one orientation element to facilitate proper insertion of the ampoule into an aerosolization device.
12. An ampoule as in claim 11, further comprising a pair of orientation elements that comprise a pair of longitudinal rails on the ampoule body that are adapted to guide the ampoule into the aerosolization device in a particular orientation.
13. An ampoule as in claim 12, wherein the rails have different sizes so that the ampoule may be inserted into the aerosolization device in only one orientation.
14. An ampoule as in claim 11, further comprising a top tab that is coupled to the top end, wherein the top tab is removable to create the drain vent in the top end, and a bottom tab that is coupled to the bottom end, wherein the bottom tab is removable to create the drain opening in the bottom end.
15. An ampoule as in claim 14, wherein the top tab and the bottom tab are coupled to the ampoule body such that they are removable by applying a twisting action.
16. An ampoule as in claim 14, further comprising a shroud disposed about the top tab, wherein the shroud is bendable to provide access to the top tab.
17. An ampoule as in claim 11, wherein the bottom end is tapered to provide a surface area at the bottom end that is adapted to provide a seal with an aerosolization device.
18. An ampoule as in claim 11, further comprising at least one keying element on the ampoule body that is adapted to permit operation of the aerosolization device when the keying element is accepted by the aerosolization device.
19. An ampoule as in claim 18, wherein the keying element comprises a protrusion extending from the ampoule body.
20. An ampoule as in claim 18, wherein the keying element comprises a readable pattern on the ampoule body.
21. A fluid filled ampoule, comprising:
an ampoule body having a top end, a bottom end, and a sealed interior containing a liquid, wherein the top end and the bottom end are each adapted to be opened to provide respective vent and drain openings; and at least one keying element on the ampoule body that is adapted to permit operation of an aerosolization device when the keying element is accepted by the aerosolization device.
22. An ampoule as in claim 21, wherein the keying element comprises a protrusion extending from the ampoule body.
23. An ampoule as in claim 21, wherein the keying element comprises a readable pattern on the ampoule body.
24. An ampoule as in claim 21, further comprising at least one orientation element to facilitate proper insertion of the ampoule into the aerosolization device.
25. An ampoule as in claim 24, further comprising a pair of orientation elements that comprise a pair of longitudinal rails on the ampoule body that are adapted to guide the ampoule into the aerosolization device in a particular orientation.
26. An ampoule as in claim 25, wherein the rails have different sizes so that the ampoule may be inserted into the aerosolization device in only one orientation.
27. An ampoule as in claim 21, wherein the bottom end is tapered to provide a surface area at the bottom end that is adapted to provide a seal with the aerosolization device.
28. An ampoule as in claim 21, further comprising a top tab that is coupled to the top end, wherein the top tab is removable to create the drain vent in the top end, and a bottom tab that is coupled to the bottom end, wherein the bottom tab is removable to create the drain opening in the bottom end.
29. An ampoule as in claim 28, wherein the top tab and the bottom tab are coupled to the ampoule body such that they are removable by applying a twisting action.
30. An ampoule as in claim 28, further comprising a shroud disposed about the top tab, wherein the shroud is bendable to provide access to the top tab.
31. A method for supplying liquid to an aerosolization device, the method comprising:
providing an ampoule comprising an ampoule body having a top end, a bottom end, and a sealed interior containing a liquid, a top tab that is coupled to the top end, a bottom tab that is coupled to the bottom end, and a shroud disposed about the top tab;
moving the shroud away from the tab;
removing the top tab to create a drain vent;
removing the .bottom tab to create a drain opening;
wherein upon creation of the drain vent and the drain opening, the liquid in the interior flows out of the drain opening and is available for aerosolization by an aerosolization device.
32. A method as in claim 31, further comprising inserting the ampoule into the aerosolization device after removing the bottom tab and prior to removing the top tab.
33. A method as in claim 31, further comprising bending the shroud to move the shroud away from the top tab.
34. A method as in claim 31, further comprising twisting the top tab and the bottom tab to remove them from the ampoule body.
35. A method as in claim 31, wherein the ampoule further includes a pair of longitudinal rails on the ampoule body, and further comprising inserting the ampoule into the aerosolization device such that the rails are received into corresponding slots in the aerosolization device.
36. A method as in claim 35, wherein the rails and the slots have different sizes, and further comprising inserting the ampoule such that the rails and received into the appropriately sized slots.
37. A method as in claim 32, wherein the bottom end is tapered, and further comprising providing a seal with the bottom end and the aerosolization device.
38. A method as in claim 31, wherein the ampoule further includes at least one keying element on the ampoule body, and further comprising inserting the aerosolization device and permitting operation of the aerosolization device only when the keying element is accepted by the aerosolization device.
39. A method as in claim 38, wherein the keying element comprises a protrusion on the ampoule body, and further comprising inserting the ampoule into the aerosolization device such that the protrusion is received into a keyed slot in the aerosolization device.
CA2441587A 2001-03-20 2002-03-19 Fluid filled ampoules and methods for their use in aerosolizers Expired - Lifetime CA2441587C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US09/812,755 US7100600B2 (en) 2001-03-20 2001-03-20 Fluid filled ampoules and methods for their use in aerosolizers
US09/812,755 2001-03-20
PCT/US2002/008380 WO2002074374A1 (en) 2001-03-20 2002-03-19 Fluid filled ampoules and methods for their use in aerosolizers

Publications (2)

Publication Number Publication Date
CA2441587A1 true CA2441587A1 (en) 2002-09-26
CA2441587C CA2441587C (en) 2010-07-27

Family

ID=25210528

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2441587A Expired - Lifetime CA2441587C (en) 2001-03-20 2002-03-19 Fluid filled ampoules and methods for their use in aerosolizers

Country Status (4)

Country Link
US (5) US7100600B2 (en)
EP (1) EP1370316B1 (en)
CA (1) CA2441587C (en)
WO (1) WO2002074374A1 (en)

Families Citing this family (98)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5758637A (en) 1995-08-31 1998-06-02 Aerogen, Inc. Liquid dispensing apparatus and methods
US20030180351A1 (en) * 1998-11-06 2003-09-25 Reinhard Gluck Pharmaceutically active composition and dispensing device
US6235177B1 (en) 1999-09-09 2001-05-22 Aerogen, Inc. Method for the construction of an aperture plate for dispensing liquid droplets
US8336545B2 (en) 2000-05-05 2012-12-25 Novartis Pharma Ag Methods and systems for operating an aerosol generator
US7100600B2 (en) * 2001-03-20 2006-09-05 Aerogen, Inc. Fluid filled ampoules and methods for their use in aerosolizers
US7971588B2 (en) 2000-05-05 2011-07-05 Novartis Ag Methods and systems for operating an aerosol generator
US6668827B2 (en) * 2000-05-16 2003-12-30 Nektar Therapeutics Systems devices and methods for opening receptacles having a powder to be fluidized
CA2466214A1 (en) * 2001-09-12 2003-04-03 Ivax U.K., Ltd. Breath-enhanced ultrasonic nebulizer and dedicated unit dose ampoule
GB0129187D0 (en) * 2001-12-06 2002-01-23 Dca Design Int Ltd Improvements in and relating to a medicament cartridge
GB0129184D0 (en) * 2001-12-06 2002-01-23 Dca Design Int Ltd Improvements in and relating to a medicament cartridge
CA2472644C (en) 2002-01-07 2013-11-05 Aerogen, Inc. Devices and methods for nebulizing fluids for inhalation
US7677467B2 (en) 2002-01-07 2010-03-16 Novartis Pharma Ag Methods and devices for aerosolizing medicament
ES2603067T3 (en) 2002-01-15 2017-02-23 Novartis Ag Methods and systems for operating an aerosol generator
EP1509259B1 (en) 2002-05-20 2016-04-20 Novartis AG Apparatus for providing aerosol for medical treatment and methods
US6966649B2 (en) * 2002-08-12 2005-11-22 John H Shadduck Adaptive optic lens system and method of use
US7718189B2 (en) 2002-10-29 2010-05-18 Transave, Inc. Sustained release of antiinfectives
DE10258360A1 (en) * 2002-12-12 2004-06-24 Boehringer Ingelheim Pharma Gmbh & Co. Kg Chamber for accommodation of disposable capsules for powder inhalers has an inner surface with protruding elements serving as distance pieces between the capsules
US7284553B2 (en) 2002-12-12 2007-10-23 Boehringer Ingelheim Pharma Gmbh & Co. Kg Powder inhaler comprising a chamber for a capsule for taking up a non-returnable capsule being filled with an active ingredient
US8545463B2 (en) * 2003-05-20 2013-10-01 Optimyst Systems Inc. Ophthalmic fluid reservoir assembly for use with an ophthalmic fluid delivery device
DE602004031829D1 (en) 2003-05-20 2011-04-28 Collins OPHTHALMIC DRUG DELIVERY SYSTEM
US8616195B2 (en) 2003-07-18 2013-12-31 Novartis Ag Nebuliser for the production of aerosolized medication
US7946291B2 (en) 2004-04-20 2011-05-24 Novartis Ag Ventilation systems and methods employing aerosol generators
FR2875138B1 (en) 2004-09-15 2008-07-11 Mallinckrodt Dev France Sa CONTROL METHOD FOR A HEATING HUMIDIFIER
DE102004054151A1 (en) * 2004-11-08 2006-05-18 Bernd Hansen Ampoule container comprises plastic layer, discharge chamber having container openings closed by closing part form of a gag fastener and discharge medium stored in the chamber and discharged through the openings at their end sides
US7513397B2 (en) * 2004-11-24 2009-04-07 Holopack International Corp. Dispensing container
EP1846587A1 (en) * 2005-02-09 2007-10-24 Arrow International Limited Sealing of plastic containers
US20060177610A1 (en) * 2005-02-09 2006-08-10 Arrow International Limited Sealing of Plastic Containers
DE102005006372B4 (en) * 2005-02-11 2007-11-29 Pari GmbH Spezialisten für effektive Inhalation Inhalation therapy device and method for its operation
US7512625B2 (en) * 2005-04-01 2009-03-31 International Business Machines Corporation Method, system and program for joining source table rows with target table rows
JP5064383B2 (en) 2005-05-25 2012-10-31 エアロジェン，インコーポレイテッド Vibration system and method
DE102005034892A1 (en) * 2005-07-26 2007-02-08 Hexal Ag Cycloolefin copolymer bottle with a scratch-resistant coating
DE102005038619A1 (en) 2005-08-16 2007-02-22 Pari GmbH Spezialisten für effektive Inhalation An inhalation therapy device with an ampoule for storing a medicament to be nebulised
JP4929282B2 (en) * 2005-08-23 2012-05-09 エアロジェン，インコーポレイテッド Self-sealing T-parts and T-parts with valves
DE102005050403A1 (en) * 2005-10-19 2007-05-03 Bayer Cropscience Ag Tube or bottle-like container
EP3067047B1 (en) 2005-12-08 2022-04-20 Insmed Incorporated Lipid-based compositions of antiinfectives for treating pulmonary infections
US20080000798A1 (en) * 2006-03-20 2008-01-03 Werner Gutmann Dose packaging system for load-dose titration administration of a liquid formulation
EP3354260B1 (en) * 2006-04-06 2020-12-09 Insmed Incorporated Methods for coacervation induced liposomal encapsulation and formulations thereof
DE102006016904A1 (en) 2006-04-11 2007-10-25 Boehringer Ingelheim Pharma Gmbh & Co. Kg inhaler
US20080029556A1 (en) * 2006-08-03 2008-02-07 Jan-Sun Chen Liquid soap leakage-proof structure for soap dispensing apparatus
DE102007009457A1 (en) * 2007-02-27 2008-08-28 Bernd Hansen Container i.e. hermetically sealed ampoule, for storing e.g. medical gel, has handling aids formed as tags, where one aid is attached at end that is at distance from dispensing opening of body, and other aid is attached at closing part
CN101663206B (en) * 2007-04-27 2011-05-11 大和制罐株式会社 Polyester resin container with break part and process for producing the same
WO2008137717A1 (en) * 2007-05-04 2008-11-13 Transave, Inc. Compositions of multicationic drugs for reducing interactions with polyanionic biomolecules and methods and uses thereof
US9119783B2 (en) 2007-05-07 2015-09-01 Insmed Incorporated Method of treating pulmonary disorders with liposomal amikacin formulations
US9114081B2 (en) 2007-05-07 2015-08-25 Insmed Incorporated Methods of treating pulmonary disorders with liposomal amikacin formulations
US9333214B2 (en) 2007-05-07 2016-05-10 Insmed Incorporated Method for treating pulmonary disorders with liposomal amikacin formulations
DE102007056462B4 (en) 2007-11-23 2011-10-27 Pari Pharma Gmbh Disposable ampoule for a device for generating aerosols
US8323251B2 (en) * 2008-01-14 2012-12-04 Fenwal, Inc. Phlebotomy needle assembly and frangible cover
US10016568B2 (en) * 2009-11-25 2018-07-10 Boehringer Ingelheim International Gmbh Nebulizer
US20130269684A1 (en) 2012-04-16 2013-10-17 Dance Pharmaceuticals, Inc. Methods and systems for supplying aerosolization devices with liquid medicaments
US8950394B2 (en) * 2010-01-12 2015-02-10 Dance Biopharm Inc. Preservative-free single dose inhaler systems
US10842951B2 (en) 2010-01-12 2020-11-24 Aerami Therapeutics, Inc. Liquid insulin formulations and methods relating thereto
US9545488B2 (en) 2010-01-12 2017-01-17 Dance Biopharm Inc. Preservative-free single dose inhaler systems
EP2347750A1 (en) * 2010-01-26 2011-07-27 Fresenius Kabi Deutschland GmbH Connector for containers containing medical agents
US8733935B2 (en) 2010-07-15 2014-05-27 Corinthian Ophthalmic, Inc. Method and system for performing remote treatment and monitoring
US10154923B2 (en) 2010-07-15 2018-12-18 Eyenovia, Inc. Drop generating device
KR101545413B1 (en) 2010-07-15 2015-08-18 아이노비아 인코포레이티드 Drop generating device
MX2013000604A (en) 2010-07-15 2013-07-05 Corinthian Ophthalmic Inc Ophthalmic drug delivery.
US9132243B2 (en) * 2010-07-23 2015-09-15 Tannermedico A/S Method of administering a substance to the throat
AU2011305566A1 (en) 2010-09-22 2013-05-02 Map Pharmaceuticals, Inc. Aerosol composition for administering drugs
US20120267335A1 (en) * 2010-10-19 2012-10-25 Chris Cindrich Ampoule with protective sleeve for contamination prevention
EP2457609A1 (en) * 2010-11-24 2012-05-30 PARI Pharma GmbH Aerosol generator
US8826904B2 (en) 2011-07-12 2014-09-09 Cardeas Pharma Corporation Formulations of aminoglycoside and fosfomycin combinations and methods and systems for treatment of ventilator associated pneumonia (VAP) and ventilator associated tracheal (VAT) bronchitis
KR20140025534A (en) 2011-07-12 2014-03-04 카르데아스 파마 인코퍼레이티드 Formulations of amikacin and fosfomycin combinations and methods and systems for treatment of ventilator associated pneumonia(vap) and ventilator associated tracheal(vat) bronchitis
US20130018329A1 (en) * 2011-07-14 2013-01-17 Mehta Ketan C Portable ampoule with a specialized tip and sealer
US20130150812A1 (en) 2011-12-12 2013-06-13 Corinthian Ophthalmic, Inc. High modulus polymeric ejector mechanism, ejector device, and methods of use
WO2013159073A1 (en) * 2012-04-20 2013-10-24 Pedia Solutions, Llc Apparatus and methods for oral administration of fluids and medical instrumentation
CN104349783B (en) 2012-05-21 2018-07-13 英斯麦德公司 The system for treating pulmonary infection
US9364393B1 (en) * 2012-08-17 2016-06-14 Healthstar, Inc. Packaging system for liquid medications
RU2675859C2 (en) 2012-11-29 2018-12-25 Инсмед Инкорпорейтед Stabilised vancomycin formulations
US9642980B2 (en) 2013-03-15 2017-05-09 Trudell Medical International Ventilator circuit, adapter for use in ventilator circuit and methods for the use thereof
WO2014172455A1 (en) 2013-04-16 2014-10-23 Dance Biopharm Inc. Liquid dispensing and methods for dispensing liquids
USD740430S1 (en) 2013-04-19 2015-10-06 Pedia Solutions, Llc Fluid dispensing pacifier
US9108777B1 (en) * 2014-03-14 2015-08-18 Soltech International Inc. Child resistant blow-fill seal container
DE102014003487A1 (en) * 2014-03-14 2015-09-17 Kocher-Plastik Maschinenbau Gmbh Container with a safety device
PT3142643T (en) 2014-05-15 2019-10-28 Insmed Inc Methods for treating pulmonary non-tuberculous mycobacterial infections
US10307550B2 (en) 2014-06-09 2019-06-04 Dance Biopharm Inc. Liquid drug cartridges and associated dispenser
US10471222B2 (en) 2014-07-01 2019-11-12 Dance Biopharm Inc. Aerosolization system with flow restrictor and feedback device
US10857313B2 (en) 2014-07-01 2020-12-08 Aerami Therapeutics, Inc. Liquid nebulization systems and methods
US11273271B2 (en) 2014-07-01 2022-03-15 Aerami Therapeutics, Inc. Aerosolization system with flow restrictor and feedback device
ES2825973T5 (en) 2014-08-28 2024-04-09 Norton Waterford Ltd Compliance monitoring module for a breath-actuated inhaler
AU2015339828B2 (en) * 2014-10-29 2020-03-19 R.P. Scherer Technologies, Llc Inverse blow-fill-seal packaging
CA3011902C (en) 2015-02-25 2023-08-15 Dance Biopharm, Inc. Liquid insulin formulations and methods relating thereto
USD785159S1 (en) * 2015-04-22 2017-04-25 Mars, Incorporated Capsule nozzle
USD801809S1 (en) * 2015-04-22 2017-11-07 Mars, Incorporated Capsule nozzle
WO2017001925A1 (en) 2015-07-02 2017-01-05 Marc Andrew Koska Single use delivery device prefilled with a reconstitutable agent
CA3021989A1 (en) 2016-04-25 2017-11-02 Marc Andrew Koska Medical delivery system
US10758686B2 (en) 2017-01-31 2020-09-01 Altria Client Services Llc Aerosol-generating device and aerosol-generating system
US11938056B2 (en) 2017-06-10 2024-03-26 Eyenovia, Inc. Methods and devices for handling a fluid and delivering the fluid to the eye
EP3710086A4 (en) 2017-11-17 2021-11-17 Koska Family Limited Systems and methods for fluid delivery manifolds
DE102018115344A1 (en) * 2017-12-05 2019-06-06 Andreas Hiemer Device for discharging a flowable substance
AU2019237571A1 (en) * 2018-03-23 2020-10-15 Terumo Kabushiki Kaisha Drug-filled synthetic resin ampule, and synthetic resin ampule body used therein
EP3773505A4 (en) 2018-03-30 2021-12-22 Insmed Incorporated Methods for continuous manufacture of liposomal drug products
USD860638S1 (en) * 2018-06-05 2019-09-24 Curv Brands, Llc Two-piece keychain
US20210121645A1 (en) * 2019-10-28 2021-04-29 NS3 Biotech LLC Single-use dispenser with multiple delivery options
US20220387256A1 (en) * 2021-06-03 2022-12-08 Kent Byron Vial With Metered Dispenser
USD992110S1 (en) 2021-08-10 2023-07-11 Koska Family Limited Sealed fluid container
FR3132826A1 (en) * 2022-02-24 2023-08-25 L'oreal Fluid cosmetic product container forming a refill for a main bottle
US11925748B1 (en) * 2023-06-08 2024-03-12 Microneb Tech Holdings, Inc. Apparatus, methods, and systems for administering a medication to a patient from a capsule using an atomizer

Family Cites Families (236)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US550315A (en) * 1895-11-26 Frank napoleon allen
US2735427A (en) 1956-02-21 Hypodermic syringe
US809159A (en) 1905-09-30 1906-01-02 Richard M Willis Dispensing bottle or jar.
US1680616A (en) * 1922-06-06 1928-08-14 Horst Friedrich Wilhelm Sealed package
US1718595A (en) * 1927-03-25 1929-06-25 Arthur E Smith Ampul
US2022520A (en) * 1934-07-07 1935-11-26 Parsons Ammonia Company Inc Bottle
US2101304A (en) 1936-06-05 1937-12-07 Sheaffer W A Pen Co Fountain pen
US2187528A (en) 1937-06-07 1940-01-16 Russell T Wing Fountain pen
US2158615A (en) 1937-07-26 1939-05-16 Sheaffer W A Pen Co Fountain pen
US2266706A (en) 1938-08-06 1941-12-16 Stanley L Fox Nasal atomizing inhaler and dropper
BE436027A (en) 1939-01-06
US2297335A (en) * 1939-04-21 1942-09-29 T C Wheaton Co Ampoule and method of making it
US2292381A (en) 1940-12-24 1942-08-11 Esterbrook Steel Pen Mfg Co Fountain pen feed
US2283333A (en) 1941-05-22 1942-05-19 Sheaffer W A Pen Co Fountain pen
US2383098A (en) 1942-07-21 1945-08-21 Jr Frank H Wheaton Double-mouthed bottle
US2375770A (en) 1943-11-19 1945-05-15 Arthur O Dahiberg Fountain pen
US2430023A (en) 1944-01-27 1947-11-04 Esterbrook Pen Co Writing implement
NL63900C (en) 1944-04-10
US2404063A (en) 1944-04-27 1946-07-16 Parker Pen Co Fountain pen
US2521657A (en) 1944-07-07 1950-09-05 Scripto Inc Fountain pen
US2512004A (en) 1945-03-05 1950-06-20 Russell T Wing Fountain pen
US2474996A (en) 1945-10-12 1949-07-05 Sheaffer W A Pen Co Fountain pen
NL68028C (en) 1946-06-08
US2517604A (en) * 1948-08-04 1950-08-08 Owens Illinois Glass Co Ampoule with breakable neck
US2705007A (en) * 1951-09-10 1955-03-29 Louis P Gerber Inhaler
US2764979A (en) * 1953-04-09 1956-10-02 Henderson Edward Medicament dispensing unit
US2764946A (en) 1954-04-05 1956-10-02 Scognamillo Frank Rotary pump
US2779623A (en) 1954-09-10 1957-01-29 Bernard J Eisenkraft Electromechanical atomizer
US2935970A (en) 1955-03-23 1960-05-10 Sapphire Products Inc Fountain pen ink reservoir
US3103310A (en) 1961-11-09 1963-09-10 Exxon Research Engineering Co Sonic atomizer for liquids
FR1449600A (en) * 1964-09-14 1966-05-06 Fr Des Laboratoires Labaz Soc Improvements to flexible material bottles, especially for medicinal products
US3680954A (en) 1965-04-30 1972-08-01 Eastman Kodak Co Electrography
DE1461628A1 (en) 1965-04-30 1969-03-27 Montblanc Simplo Gmbh Ink feed for fountain pen
US3459185A (en) * 1966-01-10 1969-08-05 Virtis Co Inc Ampule for freeze dried biological material maintained under partial vacuum conditions and method of obtaining said biological material from said ampule without contaminating the surrounding atmosphere
US3535070A (en) * 1966-02-03 1970-10-20 Owens Illinois Inc Method of inducing stress in glass containers and container made with a stressed zone
US3550864A (en) 1967-12-11 1970-12-29 Borg Warner High efficiency flashing nozzle
US3561444A (en) 1968-05-22 1971-02-09 Bio Logics Inc Ultrasonic drug nebulizer
US3515348A (en) 1968-07-22 1970-06-02 Lewbill Ind Inc Mist-producing device
US3558052A (en) 1968-10-31 1971-01-26 F I N D Inc Method and apparatus for spraying electrostatic dry powder
US3563415A (en) 1969-06-04 1971-02-16 Multi Drop Adapter Corp Multidrop adapter
US3719328A (en) 1970-10-22 1973-03-06 C Hindman Adjustable spray head
US3688812A (en) * 1971-02-17 1972-09-05 Oceanography Intern Corp Method for sealing ampoules
US3738574A (en) 1971-06-15 1973-06-12 Siemens Ag Apparatus for atomizing fluids with a piezoelectrically stimulated oscillator system
US3838686A (en) 1971-10-14 1974-10-01 G Szekely Aerosol apparatus for inhalation therapy
US3983740A (en) 1971-12-07 1976-10-05 Societe Grenobloise D'etudes Et D'applications Hydrauliques (Sogreah) Method and apparatus for forming a stream of identical drops at very high speed
US3790079A (en) 1972-06-05 1974-02-05 Rnb Ass Inc Method and apparatus for generating monodisperse aerosol
US3778786A (en) 1972-06-28 1973-12-11 Nasa Data storage, image tube type
US3812854A (en) 1972-10-20 1974-05-28 A Michaels Ultrasonic nebulizer
US3842833A (en) 1972-12-11 1974-10-22 Ims Ltd Neb-u-pack
US3858739A (en) * 1973-03-05 1975-01-07 Barnes Hind Diagnostics Inc Breakaway neck container with integral cap
FR2224175B1 (en) * 1973-04-04 1978-04-14 Isf Spa
US3804329A (en) 1973-07-27 1974-04-16 J Martner Ultrasonic generator and atomizer apparatus and method
US3903884A (en) 1973-08-15 1975-09-09 Becton Dickinson Co Manifold nebulizer system
DE2361781A1 (en) 1973-12-12 1975-06-19 Philips Patentverwaltung WRITING WORK FOR WRITING WITH LIQUID INK
US3865106A (en) 1974-03-18 1975-02-11 Bernard P Palush Positive pressure breathing circuit
US3951313A (en) * 1974-06-05 1976-04-20 Becton, Dickinson And Company Reservoir with prepacked diluent
US3993223A (en) * 1974-07-25 1976-11-23 American Home Products Corporation Dispensing container
US3908654A (en) * 1974-08-02 1975-09-30 Rit Rech Ind Therapeut Dispensing package for a dry biological and a liquid diluent
DE2445791C2 (en) 1974-09-25 1984-04-19 Siemens AG, 1000 Berlin und 8000 München Ultrasonic liquid atomizer
AR205589A1 (en) * 1974-10-09 1976-05-14 Reckitt & Colmann Prod Ltd INTRODUCING DEVICE OF AN AQUEOUS COMPOSITION INTO A BODY CAVITY
US3958249A (en) 1974-12-18 1976-05-18 International Business Machines Corporation Ink jet drop generator
US4059384A (en) 1975-01-20 1977-11-22 Misto2 Gen Equipment Co. Two-step injection molding
AT337345B (en) 1975-02-05 1977-06-27 Draegerwerk Ag BREATHING ASSISTANCE DEVICE AND / OR ARTIFICIAL VENTILATION DEVICE FOR HUMAN USE
US4005435A (en) 1975-05-15 1977-01-25 Burroughs Corporation Liquid jet droplet generator
AU67278S (en) 1975-06-04 1975-11-12 Warner Lambert Co Bottle
DE2537765B2 (en) 1975-08-25 1981-04-09 Siemens AG, 1000 Berlin und 8000 München Medical inhalation device for the treatment of diseases of the respiratory tract
GB1571304A (en) 1976-02-24 1980-07-16 Lucas Industries Ltd Drive circuit for a piezo electric crystal
US4094317A (en) 1976-06-11 1978-06-13 Wasnich Richard D Nebulization system
US4121583A (en) 1976-07-13 1978-10-24 Wen Yuan Chen Method and apparatus for alleviating asthma attacks
US4076021A (en) 1976-07-28 1978-02-28 Thompson Harris A Positive pressure respiratory apparatus
US4083368A (en) 1976-09-01 1978-04-11 Freezer Winthrop J Inhaler
USD249958S (en) 1977-01-10 1978-10-17 Warner-Lambert Company Dispensing container for pharmaceutical diluents
US4266681A (en) * 1977-02-28 1981-05-12 Oceanography International Corporation Multiple breakpoint resealable ampoule
US4106503A (en) 1977-03-11 1978-08-15 Richard R. Rosenthal Metering system for stimulating bronchial spasm
US4159803A (en) 1977-03-31 1979-07-03 MistO2 Gen Equipment Company Chamber for ultrasonic aerosol generation
US4113809A (en) 1977-04-04 1978-09-12 Champion Spark Plug Company Hand held ultrasonic nebulizer
US4101041A (en) * 1977-08-01 1978-07-18 Becton, Dickinson And Company Prefillable, hermetically sealed container adapted for use with a humidifier or nebulizer head
US4268460A (en) 1977-12-12 1981-05-19 Warner-Lambert Company Nebulizer
USD259213S (en) 1978-03-13 1981-05-12 Automatic Liquid Packaging, Inc. Vial suitable for pharmaceuticals
DE2811248C3 (en) 1978-03-15 1981-11-26 Bosch-Siemens Hausgeräte GmbH, 7000 Stuttgart Liquid atomizer
US4298045A (en) 1978-04-17 1981-11-03 Automatic Liquid Packaging, Inc. Dispensing container with plural removable closure means unitary therewith
US4338576A (en) 1978-07-26 1982-07-06 Tdk Electronics Co., Ltd. Ultrasonic atomizer unit utilizing shielded and grounded elements
US4210155A (en) 1978-08-03 1980-07-01 Jerry Grimes Inspirational inhalation spirometer apparatus
DE2843756B2 (en) 1978-10-06 1981-07-09 Hense GmbH & Co, 4930 Detmold Device for generating an aerosol
US4240081A (en) 1978-10-13 1980-12-16 Dennison Manufacturing Company Ink jet printing
DE2849493C2 (en) 1978-11-15 1982-01-14 Carl Heyer Gmbh, Inhalationstechnik, 5427 Bad Ems Hand-held aerosol dispenser
DE2854841C2 (en) 1978-12-19 1981-03-26 Bosch-Siemens Hausgeräte GmbH, 7000 Stuttgart Liquid atomizer, preferably inhalation device
JPS5848225B2 (en) 1979-01-09 1983-10-27 オムロン株式会社 Atomization amount control method of ultrasonic liquid atomization device
DE2907348A1 (en) 1979-02-24 1980-09-04 Boehringer Sohn Ingelheim IMPROVED INHALATION DEVICES
US4207990A (en) * 1979-05-03 1980-06-17 Automatic Liquid Packaging, Inc. Hermetically sealed container with plural access ports
US4226236A (en) 1979-05-07 1980-10-07 Abbott Laboratories Prefilled, vented two-compartment syringe
US4248227A (en) * 1979-05-14 1981-02-03 Bristol-Myers Company Fluid unit dispensing device
US4240417A (en) 1979-06-13 1980-12-23 Holever Bernard K Tracheal tube adapter for ventilating apparatus
DE7917568U1 (en) 1979-06-19 1979-09-20 Bosch-Siemens Hausgeraete Gmbh, 7000 Stuttgart INHALATION DEVICE
US4254883A (en) * 1979-06-22 1981-03-10 Hoechst-Roussel Pharmaceuticals Inc. Ampul
JPS5689569A (en) 1979-12-19 1981-07-20 Canon Inc Ink jet recording head
US4368850A (en) 1980-01-17 1983-01-18 George Szekely Dry aerosol generator
DE3010178C2 (en) 1980-03-17 1985-10-03 Kraftwerk Union AG, 4330 Mülheim Slotted nozzle equipped with a quick-acting valve to induce pulsed gas flows
US4336544A (en) 1980-08-18 1982-06-22 Hewlett-Packard Company Method and apparatus for drop-on-demand ink jet printing
JPS5929118B2 (en) 1980-09-19 1984-07-18 セイコーエプソン株式会社 Palladium/nickel alloy plating liquid
US4465234A (en) 1980-10-06 1984-08-14 Matsushita Electric Industrial Co., Ltd. Liquid atomizer including vibrator
US4389071A (en) 1980-12-12 1983-06-21 Hydronautics, Inc. Enhancing liquid jet erosion
US4474251A (en) 1980-12-12 1984-10-02 Hydronautics, Incorporated Enhancing liquid jet erosion
US4374707A (en) 1981-03-19 1983-02-22 Xerox Corporation Orifice plate for ink jet printing machines
US4454877A (en) 1981-05-26 1984-06-19 Andrew Boettner Portable nebulizer or mist producing device
US4408719A (en) 1981-06-17 1983-10-11 Last Anthony J Sonic liquid atomizer
US4475113A (en) 1981-06-18 1984-10-02 International Business Machines Drop-on-demand method and apparatus using converging nozzles and high viscosity fluids
JPS5861857A (en) 1981-10-09 1983-04-13 Matsushita Electric Works Ltd Liquid atomizer
AU553251B2 (en) 1981-10-15 1986-07-10 Matsushita Electric Industrial Co., Ltd. Arrangement for ejecting liquid
US4474326A (en) 1981-11-24 1984-10-02 Tdk Electronics Co., Ltd. Ultrasonic atomizing device
CA1206996A (en) 1982-01-18 1986-07-02 Naoyoshi Maehara Ultrasonic liquid ejecting apparatus
US5073484A (en) 1982-03-09 1991-12-17 Bio-Metric Systems, Inc. Quantitative analysis apparatus and method
DE3311956A1 (en) 1982-03-31 1983-10-13 Ricoh Co., Ltd., Tokyo COLOR JET PRINTER HEAD
JPS5912775A (en) 1982-07-14 1984-01-23 Matsushita Electric Ind Co Ltd Atomizing pump unit
US5002582A (en) 1982-09-29 1991-03-26 Bio-Metric Systems, Inc. Preparation of polymeric surfaces via covalently attaching polymers
US4973493A (en) 1982-09-29 1990-11-27 Bio-Metric Systems, Inc. Method of improving the biocompatibility of solid surfaces
US5217492A (en) * 1982-09-29 1993-06-08 Bio-Metric Systems, Inc. Biomolecule attachment to hydrophobic surfaces
US4722906A (en) 1982-09-29 1988-02-02 Bio-Metric Systems, Inc. Binding reagents and methods
US5512329A (en) * 1982-09-29 1996-04-30 Bsi Corporation Substrate surface preparation
IT1156090B (en) 1982-10-26 1987-01-28 Olivetti & Co Spa INK JET PRINTING METHOD AND DEVICE
US4512341A (en) 1982-11-22 1985-04-23 Lester Victor E Nebulizer with capillary feed
US4632311A (en) 1982-12-20 1986-12-30 Matsushita Electric Industrial Co., Ltd. Atomizing apparatus employing a capacitive piezoelectric transducer
DE3320441A1 (en) 1983-06-06 1984-12-06 Siemens AG, 1000 Berlin und 8000 München WRITING DEVICE WORKING WITH LIQUID DROPLETS WITH ROD-SHAPED PIEZOELECTRIC TRANSFORMERS CONNECTED ON BOTH ENDS WITH A NOZZLE PLATE
US4544933A (en) 1983-09-20 1985-10-01 Siemens Aktiengesellschaft Apparatus and method for ink droplet ejection for a printer
EP0156409A3 (en) * 1984-02-23 1986-06-25 Jean Michel Anthony Device for moistening parts of the human body
US4593291A (en) 1984-04-16 1986-06-03 Exxon Research And Engineering Co. Method for operating an ink jet device to obtain high resolution printing
DE3574344D1 (en) 1984-08-29 1989-12-28 Omron Tateisi Electronics Co Ultrasonic atomizer
US4628890A (en) 1984-08-31 1986-12-16 Freeman Winifer W Fuel atomizer
EP0174033B1 (en) 1984-09-07 1991-03-27 OMRON Corporation Oscillating construction for an ultrasonic atomizing inhaler
US4826759A (en) 1984-10-04 1989-05-02 Bio-Metric Systems, Inc. Field assay for ligands
US4550325A (en) 1984-12-26 1985-10-29 Polaroid Corporation Drop dispensing device
DE3500985A1 (en) 1985-01-14 1986-07-17 Siemens AG, 1000 Berlin und 8000 München ARRANGEMENT FOR PRODUCING SINGLE DROPLES IN INK WRITING DEVICES
DE3523947A1 (en) * 1985-07-04 1987-01-08 Draegerwerk Ag NARCOSIS EVAPORATOR WITH INTERCHANGEABLE EVAPORATOR CHAMBER
US4659014A (en) 1985-09-05 1987-04-21 Delavan Corporation Ultrasonic spray nozzle and method
US4702418A (en) 1985-09-09 1987-10-27 Piezo Electric Products, Inc. Aerosol dispenser
US4753579A (en) 1986-01-22 1988-06-28 Piezo Electric Products, Inc. Ultrasonic resonant device
SE8601351D0 (en) * 1986-03-24 1986-03-24 Nilsson Sven Erik MANAGED ADMINISTRATION OF PHYSIOLOGICALLY ACTIVE SUBJECTS
US4799622A (en) 1986-08-05 1989-01-24 Tao Nenryo Kogyo Kabushiki Kaisha Ultrasonic atomizing apparatus
DE3627222A1 (en) 1986-08-11 1988-02-18 Siemens Ag ULTRASONIC POCKET SPRAYER
US4979959A (en) 1986-10-17 1990-12-25 Bio-Metric Systems, Inc. Biocompatible coating for solid surfaces
DE3637631C1 (en) 1986-11-05 1987-08-20 Philips Patentverwaltung Process for applying small amounts of molten, drop-shaped solder from a nozzle to surfaces to be wetted and device for carrying out the process
US4826025A (en) * 1986-11-21 1989-05-02 Toppan Printing Co., Ltd. & Mect Corp. Ampoule package
US4976259A (en) 1986-12-22 1990-12-11 Mountain Medical Equipment, Inc. Ultrasonic nebulizer
ATE46836T1 (en) 1987-03-17 1989-10-15 Lechler Gmbh & Co Kg ULTRASONIC LIQUID ATOMIZER.
JPS63230957A (en) 1987-03-20 1988-09-27 Hitachi Ltd Liquid atomizing device
US4850534A (en) 1987-05-30 1989-07-25 Tdk Corporation Ultrasonic wave nebulizer
DE3775054D1 (en) 1987-06-16 1992-01-16 Akzo Nv TWO-CHAMBER SYRINGE AND MANUFACTURING METHOD.
IL86799A (en) 1987-07-02 1993-03-15 Kabi Pharmacia Ab Method and device for injection
DE3724629A1 (en) 1987-07-22 1989-02-02 Siemens Ag PIEZOELECTRICALLY REQUIRED RESONANCE SYSTEM
US5139016A (en) 1987-08-07 1992-08-18 Sorin Biomedica S.P.A. Process and device for aerosol generation for pulmonary ventilation scintigraphy
FI82808C (en) 1987-12-31 1991-04-25 Etelae Haemeen Keuhkovammayhdi Ultraljudfinfördelningsanordning
GB8801655D0 (en) * 1988-01-26 1988-02-24 Waverley Pharma Ltd Ampoules
GB8802349D0 (en) * 1988-02-03 1988-03-02 Waverley Pharma Ltd Ampoule with luer
DE3808308A1 (en) 1988-03-12 1989-09-21 Merck Patent Gmbh OPENING AID FOR AMPOULES
DE3818682A1 (en) * 1988-06-01 1989-12-21 Deussen Stella Kg AMPOULE
DE3916840A1 (en) * 1988-09-21 1990-03-29 Bernd Hansen Ampoule with specified shape of neck - for passage of air but not liq. when syringe neck is inserted for extn.
US5021701A (en) 1988-10-20 1991-06-04 Tdk Corporation Piezoelectric vibrator mounting system for a nebulizer
USD312209S (en) 1988-10-21 1990-11-20 Becton, Dickinson And Company Dispensing vial or the like
JPH02269058A (en) 1989-03-14 1990-11-02 Seiko Epson Corp Liquid drop jet device by use of rayleigh mode surface acoustic wave
JPH03505424A (en) 1989-04-14 1991-11-28 アゼルバイジャンスキ　ポリテフニチェスキ　インスティテュト　イメニ　チェー．イルドリマ Ultrasonic atomization device for liquid media
USD330598S (en) * 1989-08-31 1992-10-27 Revlon Consumer Products Corporation Ampule
ES2042093T3 (en) 1990-02-07 1993-12-01 Arzneimittel Gmbh Apotheker Vetter & Co. Ravensburg DOUBLE CHAMBER SYRINGE AND EMPLOYMENT PROCEDURE.
US5122116A (en) * 1990-04-24 1992-06-16 Science Incorporated Closed drug delivery system
US5076452A (en) * 1990-05-01 1991-12-31 Tokyo Glass Seiki Kabushiki Kaisha Plastic receptacle
FR2665849B1 (en) * 1990-08-20 1995-03-24 Dynamad ULTRASONIC DEVICE FOR THE CONTINUOUS PRODUCTION OF PARTICLES.
USD327008S (en) 1990-08-29 1992-06-16 True Products Sampling, Inc. Cosmetic sample container
US5115803A (en) 1990-08-31 1992-05-26 Minnesota Mining And Manufacturing Company Aerosol actuator providing increased respirable fraction
EP0480615B1 (en) * 1990-10-11 1996-02-14 Kohji Toda Ultrasonic atomizing device
CA2027690A1 (en) * 1990-10-18 1992-04-19 Christian Laing Plastic ampul
NZ241034A (en) * 1990-12-17 1995-03-28 Minnesota Mining & Mfg Inhaler device with a dosage control that deactivates an aerosol generator after predetermined time or dosage
US5186164A (en) * 1991-03-15 1993-02-16 Puthalath Raghuprasad Mist inhaler
WO1992017231A1 (en) * 1991-03-28 1992-10-15 Innomed, Inc. Microelectronic inhaler having a counter and timer
US5164740A (en) 1991-04-24 1992-11-17 Yehuda Ivri High frequency printing mechanism
US5938117A (en) 1991-04-24 1999-08-17 Aerogen, Inc. Methods and apparatus for dispensing liquids as an atomized spray
DE69210096T2 (en) * 1991-05-27 1996-09-19 Tdk Corp Ultrasonic atomizer
US5180482A (en) * 1991-07-22 1993-01-19 At&T Bell Laboratories Thermal annealing of palladium alloys
US5601077A (en) * 1991-08-07 1997-02-11 Becton, Dickinson And Company Nasal syringe sprayer with removable dose limiting structure
DE4127650C1 (en) * 1991-08-21 1993-02-25 Arzneimittel Gmbh Apotheker Vetter & Co Ravensburg, 7980 Ravensburg, De
JP2849647B2 (en) * 1991-12-04 1999-01-20 ザ テクノロジー パートナーシップ ピーエルシー Apparatus and method for producing small droplets of fluid
EP0546964B1 (en) * 1991-12-10 1997-04-09 TDK Corporation An ultrasonic wave nebulizer
GB2262452B (en) * 1991-12-19 1995-12-20 Minnesota Mining & Mfg Inhalation device
FR2687066A1 (en) * 1992-02-06 1993-08-13 Oreal Auto-breakable ampoule
US5186166A (en) * 1992-03-04 1993-02-16 Riggs John H Powder nebulizer apparatus and method of nebulization
US5512474A (en) * 1992-05-29 1996-04-30 Bsi Corporation Cell culture support containing a cell adhesion factor and a positively-charged molecule
DE4230645C2 (en) * 1992-09-12 1996-03-07 Bernd Hansen ampoule
US5414075A (en) * 1992-11-06 1995-05-09 Bsi Corporation Restrained multifunctional reagent for surface modification
FR2705911B1 (en) * 1993-06-02 1995-08-11 Oreal Piezoelectric nebulization device.
US5819730A (en) * 1993-06-09 1998-10-13 Glaxo Wellcome Australia Ltd. Device for administering pharmaceutical substances
CH686872A5 (en) * 1993-08-09 1996-07-31 Disetronic Ag Medical Inhalationsgeraet.
US5415161A (en) * 1993-09-15 1995-05-16 Ryder; Steven L. Intermittant demand aerosol control device
US5423440A (en) * 1993-10-15 1995-06-13 Chemetrics, Inc. Ampule for chemical oxygen demand test
GB9324250D0 (en) * 1993-11-25 1994-01-12 Minnesota Mining & Mfg Inhaler
US5489266A (en) * 1994-01-25 1996-02-06 Becton, Dickinson And Company Syringe assembly and method for lyophilizing and reconstituting injectable medication
IT232769Y1 (en) * 1994-02-23 2000-01-19 Erba Carlo Reagenti Srl VIAL FOR CHEMICAL REAGENTS
US5505236A (en) * 1994-04-04 1996-04-09 Abbott Laboratories Anesthetic vaporizer filling system
AU128844S (en) * 1994-10-21 1996-12-05 Glaxo Wellcome Australia Ltd Ampoule
US5707818A (en) * 1994-12-13 1998-01-13 Bsi Corporation Device and method for simultaneously performing multiple competitive immunoassays
IT1277832B1 (en) * 1995-03-02 1997-11-12 Giuseppina Magni PACKAGING FOR NEBULIZABLE SUBSTANCES
DE59505300D1 (en) * 1995-03-09 1999-04-15 Hansen Bernd Plastic bottle and process for its manufacture
US5503628A (en) * 1995-03-15 1996-04-02 Jettek, Inc. Patient-fillable hypodermic jet injector
US5586550A (en) 1995-08-31 1996-12-24 Fluid Propulsion Technologies, Inc. Apparatus and methods for the delivery of therapeutic liquids to the respiratory system
US5758637A (en) 1995-08-31 1998-06-02 Aerogen, Inc. Liquid dispensing apparatus and methods
US6085740A (en) 1996-02-21 2000-07-11 Aerogen, Inc. Liquid dispensing apparatus and methods
US6205999B1 (en) * 1995-04-05 2001-03-27 Aerogen, Inc. Methods and apparatus for storing chemical compounds in a portable inhaler
US6014970A (en) * 1998-06-11 2000-01-18 Aerogen, Inc. Methods and apparatus for storing chemical compounds in a portable inhaler
US6017118A (en) * 1995-04-27 2000-01-25 Hewlett-Packard Company High performance ink container with efficient construction
US6183077B1 (en) * 1995-04-27 2001-02-06 Hewlett-Packard Company Method and apparatus for keying ink supply containers
WO1996037165A1 (en) * 1995-05-26 1996-11-28 Bsi Corporation Method and implantable article for promoting endothelialization
JP3320261B2 (en) * 1995-06-01 2002-09-03 株式会社ユニシアジェックス Inhaler type dispenser
US5904773A (en) * 1995-08-11 1999-05-18 Atotech Usa, Inc. Fluid delivery apparatus
US5848587A (en) * 1995-09-21 1998-12-15 Medi-Nuclear Corporation, Inc. Aerosol medication delivery system
KR0124764Y1 (en) * 1995-09-23 1998-09-15 양주환 Medical capsule
US5639851A (en) * 1995-10-02 1997-06-17 Ethicon, Inc. High strength, melt processable, lactide-rich, poly(lactide-CO-P-dioxanone) copolymers
JP3317827B2 (en) * 1995-10-09 2002-08-26 株式会社ユニシアジェックス Dosing device
US5714360A (en) * 1995-11-03 1998-02-03 Bsi Corporation Photoactivatable water soluble cross-linking agents containing an onium group
USD392184S (en) * 1996-02-21 1998-03-17 Automatic Liquid Packaging, Inc. Vial with a frangible closure
AUPN976496A0 (en) * 1996-05-10 1996-05-30 Glaxo Wellcome Australia Ltd Unit dose dispensing device
US5775506A (en) * 1996-09-25 1998-07-07 Abbott Laboratories Pharmaceutical ampul
DE19647947A1 (en) * 1996-11-20 1998-05-28 Pfeiffer Erich Gmbh & Co Kg Discharge device for media
US5908124A (en) * 1997-11-03 1999-06-01 Owens-Brockway Plastic Products Inc. One piece blow molded plastic squeeze tube with an integral twist off closure
US6068148A (en) * 1998-05-26 2000-05-30 Automatic Liquid Packaging, Inc. Hermetically sealed container including a nozzle with a sealing bead
JP3747134B2 (en) * 1998-11-04 2006-02-22 キヤノン株式会社 Inkjet printhead cartridge storage container
US6244487B1 (en) * 1999-01-22 2001-06-12 William M. Murray Safety ampule breaker
US6235177B1 (en) * 1999-09-09 2001-05-22 Aerogen, Inc. Method for the construction of an aperture plate for dispensing liquid droplets
AU142571S (en) * 1999-11-05 2000-12-18 Astrazeneca Ab Plastic ampoule
US6948491B2 (en) * 2001-03-20 2005-09-27 Aerogen, Inc. Convertible fluid feed system with comformable reservoir and methods
US7100600B2 (en) * 2001-03-20 2006-09-05 Aerogen, Inc. Fluid filled ampoules and methods for their use in aerosolizers
US6543443B1 (en) * 2000-07-12 2003-04-08 Aerogen, Inc. Methods and devices for nebulizing fluids
USD460175S1 (en) * 2000-09-11 2002-07-09 Kent A. Louviere Medical vials
USD458676S1 (en) * 2000-12-12 2002-06-11 FLO2W, Inc. Medicine vial
US6722364B2 (en) * 2001-01-12 2004-04-20 Becton, Dickinson And Company Medicament inhalation delivery devices and methods for using the same
US6550472B2 (en) * 2001-03-16 2003-04-22 Aerogen, Inc. Devices and methods for nebulizing fluids using flow directors
USD489820S1 (en) * 2001-05-29 2004-05-11 Otsuka Pharmaceutical Co., Ltd. Package for medical fluid
USD492407S1 (en) * 2001-05-29 2004-06-29 Otsuka Pharmaceutical Co., Ltd. Package for medical fluid
USD469867S1 (en) * 2001-11-28 2003-02-04 Otsuka Pharmaceutical Co., Ltd. Portion of a package for medical fluid
ES2603067T3 (en) * 2002-01-15 2017-02-23 Novartis Ag Methods and systems for operating an aerosol generator

Also Published As

Publication number Publication date
US20060169279A1 (en) 2006-08-03
EP1370316A4 (en) 2006-08-23
WO2002074374A1 (en) 2002-09-26
US7032590B2 (en) 2006-04-25
EP1370316A1 (en) 2003-12-17
US20020134377A1 (en) 2002-09-26
US20020134374A1 (en) 2002-09-26
US20040139968A1 (en) 2004-07-22
EP1370316B1 (en) 2019-02-27
WO2002074374A9 (en) 2002-12-27
CA2441587C (en) 2010-07-27
US7100600B2 (en) 2006-09-05
US20020134375A1 (en) 2002-09-26

Similar Documents

Publication Publication Date Title
CA2441587A1 (en) Fluid filled ampoules and methods for their use in aerosolizers
DE69908776D1 (en) DEVICE FOR HANDLING BODY FLUIDS THAT TRANSFER BODY FLUIDS BY EXTRACTION
EP1235625A4 (en) Apparatus and methods for pumping high viscosity fluids
DE60123805D1 (en) BLASHED CONTAINER AND CLOSURE, AND METHOD AND DEVICE FOR MAKING THE SAME
BR0108719A (en) Method and apparatus for handling various body fluids
DE69424617D1 (en) Fluid pressure operated device for performing multiple operations in the borehole
EP1412455A4 (en) Continuous liquid hydrocarbon treatment method
EP1205252A4 (en) Method and device for forming trace-amount liquid droplet
WO2002060582A3 (en) Microfluidic devices for introducing and dispensing fluids from microfluidic systems
AU2001265128A1 (en) Methods and devices for sealing microchip reservoir devices
PL342609A1 (en) Medical fluid holding container
WO2002102295A3 (en) Spike for liquid transfer device, liquid transfer device including spike, and method of transferring liquids using the same
HK1038905B (en) Controllable fluid gripping devices, a manual implement having a gripping devices and a using method thereof
HRP20070257T3 (en) A method for dispensing a beverage and devices therefor
WO2005096779A3 (en) Clot retainer
IL152967A0 (en) Tapping device and container therefor, and method for the manufacture thereof
EP1120165A3 (en) Apparatus and method for liquid transfer
ATE241479T1 (en) METHOD FOR INSERTING PRINTED PRODUCTS INTO A FOLDED MAIN PRODUCT
CA2353162A1 (en) Method and device for clearing a re-imageable printing form
WO2004096081A3 (en) Transfer needle safety apparatus
CA2367551A1 (en) Transfer of shear-thinning slurries
AU6838600A (en) Devices and methods for removing pathogens from biological fluids
DE60305883D1 (en) teabag
IL136519A0 (en) Method for treating contaminated liquid
AR248109A1 (en) Method and apparatus for inserting a bag into a bottle

Legal Events

Date Code Title Description
EEER Examination request
MKEX Expiry

Effective date: 20220321