CA2439896A1 - Improvements in and relating to an injection device - Google Patents

Improvements in and relating to an injection device Download PDF

Info

Publication number
CA2439896A1
CA2439896A1 CA002439896A CA2439896A CA2439896A1 CA 2439896 A1 CA2439896 A1 CA 2439896A1 CA 002439896 A CA002439896 A CA 002439896A CA 2439896 A CA2439896 A CA 2439896A CA 2439896 A1 CA2439896 A1 CA 2439896A1
Authority
CA
Canada
Prior art keywords
belt
drive
injection device
semi rigid
drive mechanism
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA002439896A
Other languages
French (fr)
Other versions
CA2439896C (en
Inventor
Christopher Nigel Langley
David Aubrey Plumptre
Robert Woolston
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
DCA Design International Ltd
Original Assignee
Dca Design International Limited
Christopher Nigel Langley
David Aubrey Plumptre
Robert Woolston
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Dca Design International Limited, Christopher Nigel Langley, David Aubrey Plumptre, Robert Woolston filed Critical Dca Design International Limited
Publication of CA2439896A1 publication Critical patent/CA2439896A1/en
Application granted granted Critical
Publication of CA2439896C publication Critical patent/CA2439896C/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/20—Automatic syringes, e.g. with automatically actuated piston rod, with automatic needle injection, filling automatically
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
    • A61M5/31511—Piston or piston-rod constructions, e.g. connection of piston with piston-rod
    • A61M5/31513—Piston constructions to improve sealing or sliding
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
    • A61M5/31533—Dosing mechanisms, i.e. setting a dose
    • A61M5/31545—Setting modes for dosing
    • A61M5/31548—Mechanically operated dose setting member
    • A61M5/3155—Mechanically operated dose setting member by rotational movement of dose setting member, e.g. during setting or filling of a syringe
    • A61M5/31553—Mechanically operated dose setting member by rotational movement of dose setting member, e.g. during setting or filling of a syringe without axial movement of dose setting member
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
    • A61M5/31511—Piston or piston-rod constructions, e.g. connection of piston with piston-rod
    • A61M2005/31518—Piston or piston-rod constructions, e.g. connection of piston with piston-rod designed to reduce the overall size of an injection device, e.g. using flexible or pivotally connected chain-like rod members
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
    • A61M5/31511—Piston or piston-rod constructions, e.g. connection of piston with piston-rod
    • A61M2005/3152—Piston or piston-rod constructions, e.g. connection of piston with piston-rod including gearings to multiply or attenuate the piston displacing force
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/24—Ampoule syringes, i.e. syringes with needle for use in combination with replaceable ampoules or carpules, e.g. automatic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
    • A61M5/31533—Dosing mechanisms, i.e. setting a dose
    • A61M5/31545—Setting modes for dosing
    • A61M5/31548—Mechanically operated dose setting member
    • A61M5/31556—Accuracy improving means
    • A61M5/31558—Accuracy improving means using scaling up or down transmissions, e.g. gearbox
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
    • A61M5/31533—Dosing mechanisms, i.e. setting a dose
    • A61M5/31545—Setting modes for dosing
    • A61M5/31548—Mechanically operated dose setting member
    • A61M5/31561—Mechanically operated dose setting member using freely adjustable volume steps
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
    • A61M5/31533—Dosing mechanisms, i.e. setting a dose
    • A61M5/31545—Setting modes for dosing
    • A61M5/31548—Mechanically operated dose setting member
    • A61M5/31563—Mechanically operated dose setting member interacting with a displaceable stop member
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
    • A61M5/31565—Administration mechanisms, i.e. constructional features, modes of administering a dose
    • A61M5/31576—Constructional features or modes of drive mechanisms for piston rods
    • A61M5/31578—Constructional features or modes of drive mechanisms for piston rods based on axial translation, i.e. components directly operatively associated and axially moved with plunger rod
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
    • A61M5/31565—Administration mechanisms, i.e. constructional features, modes of administering a dose
    • A61M5/3159—Dose expelling manners
    • A61M5/31593—Multi-dose, i.e. individually set dose repeatedly administered from the same medicament reservoir

Abstract

Injection devices are known for the self administration of a medicament by patients in which the medicament is contained within a cartridge located within the injection device. It is a problem that such injection devices should be small enough to fit into a jacket pocket or a hand bag without difficulty. Concurrently, the injection device must be of size that enables a piston or similar used to drive a cartridge bung within the cartridge to be moved both to a maximum dispense position within the cartridge and to be fully withdrawn from the cartridge to allow for replacement of the cartridge. A
drive mechanism for an injection device is disclosed comprising a piston member 10, a semi rigid belt 18 connected to the piston member 10, a belt drive means to selectively engage with the semi rigid belt 18 to drive the semi rigid belt 18, and a dose setting mechanism to control the selective engagement of the semi rigid belt in which the semi rigid belt 18 includes a track incorporated therein and the belt drive means comprises a tooth 50 for selective engagement with the track to drive the belt 18 only when there is relative movement between the semi rigid belt 18 and the tooth 50 in a first direction. An injection device comprising such a drive mechanism is also disclosed.

Claims (11)

1 A drive mechanism for an injection device in which a piston is successively moved in relation to a first end of a medicament cartridge (6) containing a medicament selectively to drive a bung (8) closing a first end of the medicament cartridge (6) into the medicament cartridge (6) to expel medicament through a delivery member (4) located at a second end of the medicament cartridge, in which the drive met comprises a piston member, a semi rigid belt (18) including a track incorporated therein connected to the piston member (10), a belt drive means to drive the semi rigid belt (18), and a dose setting mechanism to control the selective engagement of the semi rigid belt (18) is characterised in that the belt drive means selectively engages with the semi rigid belt (18) and in that the belt drive means comprises a tooth (50) for selective engagement with the track to drive the belt only when there is relative movement between the semi rigid belt (18) and the tooth (50) in a first direction.
2 A drive mechanism for an injection device according to claim 1, characterised in that the belt drive means further comprises an inner gear (20) adapted to engage with the track in the semi rigid belt (18) and be driven by movement of the track in the first direction.
3 A drive mechanism according to either claim 1 or claim 2, characterised in that the belt drive means further comprises a flexible member (52) to carry the tooth (50), a second piston member (34) to carry the flexible member (52) and a charge means to drive the belt drive means in the first direction.
4 A drive mechanism according to claim 3, characterised in that the charge means comprises a spring (12).
A drive mechanism according to claim 3 or claim 4, characterised in that the second piston member (34) includes a biased dose button (44) adapted releasably to retain a dosing spindle (34) in a desired position.
6 A drive mechanism for an injection device according to claim 2, characterised in that the dose setting mechanism comprises a dial dose means (42), a dosing spindle (38), an outer gear (22), an outer gear drive means located between the spindle (38) and the outer gear (22), a plurality of intermediate gears (24) interposed between the inner gear (20) and the outer gear (22), and a dose trip peg (26) carried by one of the plurality of intermediate gears (24} to control the selective engagement of the semi rigid belt (18).
7 A drive mechanism for an injection device according to claim 5, characterised in that the dose setting mechanism further comprises displacement means to displace the dosing spindle (38).
8 A drive mechanism for an injection device according to any previous claim, characterised in that the semi rigid belt (18) and the piston member (10) are formed as a unitary component.
9 An injection device having a housing, characterised in that the device further comprises a drive mechanism according to any previous claim.
An injection device according to claim 9, characterised in that the displacement means comprises a button (54) located for displacement within the housing (2) of the injection device.
11 An injection device according to either claim 9 or claim 10, characterised in that the housing has an aperture for cooperation with a or the dose button (44).
CA2439896A 2001-03-27 2002-03-26 Improvements in and relating to an injection device Expired - Fee Related CA2439896C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB0107601.7 2001-03-27
GBGB0107601.7A GB0107601D0 (en) 2001-03-27 2001-03-27 Improvements in and relating to and injection device
PCT/GB2002/001418 WO2002076535A1 (en) 2001-03-27 2002-03-26 Improvements in and relating to an injection device

Publications (2)

Publication Number Publication Date
CA2439896A1 true CA2439896A1 (en) 2002-10-03
CA2439896C CA2439896C (en) 2010-06-15

Family

ID=9911626

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2439896A Expired - Fee Related CA2439896C (en) 2001-03-27 2002-03-26 Improvements in and relating to an injection device

Country Status (15)

Country Link
US (1) US7985201B2 (en)
EP (1) EP1372768B1 (en)
JP (1) JP4350376B2 (en)
AT (1) ATE403455T1 (en)
AU (1) AU2002247840B2 (en)
CA (1) CA2439896C (en)
DE (1) DE60228060D1 (en)
DK (1) DK1372768T3 (en)
ES (1) ES2311597T3 (en)
GB (1) GB0107601D0 (en)
HK (1) HK1062412A1 (en)
IL (2) IL157603A0 (en)
MX (1) MXPA03008686A (en)
PT (1) PT1372768E (en)
WO (1) WO2002076535A1 (en)

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Also Published As

Publication number Publication date
AU2002247840B2 (en) 2007-09-06
IL157603A (en) 2009-09-01
MXPA03008686A (en) 2004-04-20
EP1372768A1 (en) 2004-01-02
JP2004533869A (en) 2004-11-11
HK1062412A1 (en) 2004-11-05
JP4350376B2 (en) 2009-10-21
US7985201B2 (en) 2011-07-26
DK1372768T3 (en) 2008-12-08
ES2311597T3 (en) 2009-02-16
WO2002076535A1 (en) 2002-10-03
CA2439896C (en) 2010-06-15
EP1372768B1 (en) 2008-08-06
PT1372768E (en) 2008-11-17
US20040087904A1 (en) 2004-05-06
DE60228060D1 (en) 2008-09-18
GB0107601D0 (en) 2001-05-16
IL157603A0 (en) 2004-03-28
ATE403455T1 (en) 2008-08-15

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Effective date: 20170327