CA2439813A1 - Porous beta-tricalcium phosphate granules and methods for producing same - Google Patents

Porous beta-tricalcium phosphate granules and methods for producing same Download PDF

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Publication number
CA2439813A1
CA2439813A1 CA002439813A CA2439813A CA2439813A1 CA 2439813 A1 CA2439813 A1 CA 2439813A1 CA 002439813 A CA002439813 A CA 002439813A CA 2439813 A CA2439813 A CA 2439813A CA 2439813 A1 CA2439813 A1 CA 2439813A1
Authority
CA
Canada
Prior art keywords
porous
beta
tcp
binder
methods
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA002439813A
Other languages
French (fr)
Other versions
CA2439813C (en
Inventor
Paresh S. Dalal
Godofredo R. Dimaano
Carol Ann Toth
Shailesh C. Kulkarni
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Stryker Corp
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=27121998&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CA2439813(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from US09/798,518 external-priority patent/US20030049328A1/en
Application filed by Individual filed Critical Individual
Priority to CA002659188A priority Critical patent/CA2659188A1/en
Publication of CA2439813A1 publication Critical patent/CA2439813A1/en
Application granted granted Critical
Publication of CA2439813C publication Critical patent/CA2439813C/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/02—Inorganic materials
    • A61L27/12—Phosphorus-containing materials, e.g. apatite
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/56—Porous materials, e.g. foams or sponges
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2430/00—Materials or treatment for tissue regeneration
    • A61L2430/02—Materials or treatment for tissue regeneration for reconstruction of bones; weight-bearing implants
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
    • Y10S530/81—Carrier - bound or immobilized peptides or proteins and the preparation thereof, e.g. biological cell or cell fragment as carrier
    • Y10S530/811—Peptides or proteins is immobilized on, or in, an inorganic carrier

Abstract

A porous .beta.-tricalcium phosphate material for bone implantation is provided. The multiple pores in the porous TCP body are separate discrete voids and are not interconnected. The pore size diameter is in the range of 20-500 ~m, preferably 50-125 ~m. The porous .beta.-TCP material provides a carrier matrix for bioactive agents and can form a moldable putty composition upon the addition of a binder. Preferably, the bioactive agent is encapsulated in a biodegradable agent. The invention provides a kit and an implant device comprising the porous .beta.-TCP, and a bioactive agent and a binder. The invention also provides an implementable prosthetic device comprising a prosthetic implant having a surface region, a porous .beta.-TCP material disposed on the surface region optionally comprising at least a bioactive agent or a binder. Methods of producing the porous .beta.-TCP material and including bone formation are also provided.
CA002439813A 2001-03-02 2002-02-26 Porous beta-tricalcium phosphate granules and methods for producing same Expired - Fee Related CA2439813C (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CA002659188A CA2659188A1 (en) 2001-03-02 2002-02-26 Porous beta-tricalcium phosphate granules and methods for producing same

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US09/798,518 US20030049328A1 (en) 2001-03-02 2001-03-02 Porous beta-tricalcium phosphate granules and methods for producing same
US09/798,518 2001-03-02
US09/960,789 US6949251B2 (en) 2001-03-02 2001-09-21 Porous β-tricalcium phosphate granules for regeneration of bone tissue
US09/960,789 2001-09-21
PCT/US2002/005827 WO2002070029A2 (en) 2001-03-02 2002-02-26 Porous beta-tricalcium phosphate granules and methods for producing same

Related Child Applications (1)

Application Number Title Priority Date Filing Date
CA002659188A Division CA2659188A1 (en) 2001-03-02 2002-02-26 Porous beta-tricalcium phosphate granules and methods for producing same

Publications (2)

Publication Number Publication Date
CA2439813A1 true CA2439813A1 (en) 2002-09-12
CA2439813C CA2439813C (en) 2009-06-16

Family

ID=27121998

Family Applications (2)

Application Number Title Priority Date Filing Date
CA002439813A Expired - Fee Related CA2439813C (en) 2001-03-02 2002-02-26 Porous beta-tricalcium phosphate granules and methods for producing same
CA002659188A Abandoned CA2659188A1 (en) 2001-03-02 2002-02-26 Porous beta-tricalcium phosphate granules and methods for producing same

Family Applications After (1)

Application Number Title Priority Date Filing Date
CA002659188A Abandoned CA2659188A1 (en) 2001-03-02 2002-02-26 Porous beta-tricalcium phosphate granules and methods for producing same

Country Status (8)

Country Link
US (4) US6949251B2 (en)
EP (1) EP1372748B1 (en)
JP (3) JP2005505311A (en)
AT (1) ATE429256T1 (en)
CA (2) CA2439813C (en)
DE (1) DE60232061D1 (en)
ES (1) ES2325573T3 (en)
WO (1) WO2002070029A2 (en)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7578845B2 (en) 2002-04-29 2009-08-25 Biomet Deutschland Gmbh Structured composites as a matrix (scaffold) for the tissue engineering of bones
CN116492450A (en) * 2023-06-25 2023-07-28 朗肽生物制药股份有限公司 Recombinant human basic fibroblast growth factor oral gel and preparation method thereof

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* Cited by examiner, † Cited by third party
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US20060292198A1 (en) 2006-12-28
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US20030180376A1 (en) 2003-09-25
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CA2659188A1 (en) 2002-09-12
US6949251B2 (en) 2005-09-27

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