CA2432241A1 - Aerosol generator having heater in multilayered composite and method of use thereof - Google Patents

Aerosol generator having heater in multilayered composite and method of use thereof Download PDF

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Publication number
CA2432241A1
CA2432241A1 CA002432241A CA2432241A CA2432241A1 CA 2432241 A1 CA2432241 A1 CA 2432241A1 CA 002432241 A CA002432241 A CA 002432241A CA 2432241 A CA2432241 A CA 2432241A CA 2432241 A1 CA2432241 A1 CA 2432241A1
Authority
CA
Canada
Prior art keywords
fluid
layer
aerosol generator
heater
fluid passage
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA002432241A
Other languages
French (fr)
Other versions
CA2432241C (en
Inventor
F. Murphy Sprinkel Jr.
Walter A. Nichols
Kenneth A. Cox
Timothy S. Sherwood
Scott A. Sowers
Zelita R. Washington
Sirisha Reddy
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Philip Morris Products SA
Original Assignee
Individual
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Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2432241A1 publication Critical patent/CA2432241A1/en
Application granted granted Critical
Publication of CA2432241C publication Critical patent/CA2432241C/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A61M15/0065—Inhalators with dosage or measuring devices
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M11/00—Sprayers or atomisers specially adapted for therapeutic purposes
    • A61M11/04—Sprayers or atomisers specially adapted for therapeutic purposes operated by the vapour pressure of the liquid to be sprayed or atomised
    • A61M11/041—Sprayers or atomisers specially adapted for therapeutic purposes operated by the vapour pressure of the liquid to be sprayed or atomised using heaters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M11/00—Sprayers or atomisers specially adapted for therapeutic purposes
    • A61M11/04—Sprayers or atomisers specially adapted for therapeutic purposes operated by the vapour pressure of the liquid to be sprayed or atomised
    • A61M11/041—Sprayers or atomisers specially adapted for therapeutic purposes operated by the vapour pressure of the liquid to be sprayed or atomised using heaters
    • A61M11/042—Sprayers or atomisers specially adapted for therapeutic purposes operated by the vapour pressure of the liquid to be sprayed or atomised using heaters electrical
    • A61M11/044—Sprayers or atomisers specially adapted for therapeutic purposes operated by the vapour pressure of the liquid to be sprayed or atomised using heaters electrical with electrodes immersed in the liquid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M16/00—Devices for influencing the respiratory system of patients by gas treatment, e.g. mouth-to-mouth respiration; Tracheal tubes
    • A61M16/0003—Accessories therefor, e.g. sensors, vibrators, negative pressure
    • A61M2016/0015—Accessories therefor, e.g. sensors, vibrators, negative pressure inhalation detectors
    • A61M2016/0018—Accessories therefor, e.g. sensors, vibrators, negative pressure inhalation detectors electrical
    • A61M2016/0021—Accessories therefor, e.g. sensors, vibrators, negative pressure inhalation detectors electrical with a proportional output signal, e.g. from a thermistor
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00—General characteristics of the apparatus
    • A61M2205/12—General characteristics of the apparatus with interchangeable cassettes forming partially or totally the fluid circuit
    • A61M2205/123—General characteristics of the apparatus with interchangeable cassettes forming partially or totally the fluid circuit with incorporated reservoirs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00—General characteristics of the apparatus
    • A61M2205/12—General characteristics of the apparatus with interchangeable cassettes forming partially or totally the fluid circuit
    • A61M2205/128—General characteristics of the apparatus with interchangeable cassettes forming partially or totally the fluid circuit with incorporated valves
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00—General characteristics of the apparatus
    • A61M2205/36—General characteristics of the apparatus related to heating or cooling
    • A61M2205/3653—General characteristics of the apparatus related to heating or cooling by Joule effect, i.e. electric resistance
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00—General characteristics of the apparatus
    • A61M2205/82—Internal energy supply devices
    • A61M2205/8206—Internal energy supply devices battery-operated

Abstract

An aerosol generator (100) includes a fluid passage (130) arranged between a first (110) and a second layer (120) wherein the first (110) and second (120 ) layers at least partially define the fluid passage (130). A liquid supply (150) is arranged to provide a fluid in liquid phase to the fluid passage (130). The aerosol generator (130) also includes a heater (180) arranged to volatilize the fluid in the fluid passage (130). An outlet (140) of the aerosol generator (100) is arranged to receive the volatilized fluid and direct the volatilized fluid out of the fluid passage (130). The aerosol generator (100) can be used to generate aerosols containing medicated materials.

Claims (29)

1. An aerosol generator, comprising:
(a) a fluid passage arranged between a first and a second layer, wherein the first and second layers at least partially define the fluid passage;
(b) a fluid supply arranged to provide a fluid in liquid phase to the fluid passage;
(c) a heater arranged to volatilize the fluid in the fluid passage; and (d) an outlet arranged to receive the volatilized fluid and direct the volatilized fluid out of the fluid passage.
2. The aerosol generator of Claim 1, wherein the fluid passage comprises a channel disposed in the first and/or second layers.
3. The aerosol generator of Claim 1, wherein the first layer is bonded to the second layer by a material selected from the group consisting of a glass, metal, a cement, an epoxy, an acrylic, a cyanoacrylic and mixtures thereof.
4. The aerosol generator of Claim 1, wherein the first layer is mechanically attached to the second layer.
5. The aerosol generator of Claim 1, further comprising a third layer defining a void space, wherein the third layer is arranged between the first and second layers, and wherein the fluid passage is further defined by the third layer defining the void space.
6. The aerosol generator of Claim 5, wherein a first surface of the third layer is bonded to the first layer, and/or a second surface of the third layer is bonded to the second layer, by a material selected from the group consisting of a glass, a metal, a cement, an epoxy, an acrylic, a cyanoacrylic and mixtures thereof.
7. The aerosol generator of Claim 5, wherein a first surface of the third layer is mechanically attached to the first layer and/or a second surface of the third layer is mechanically attached to the second layer.
8. The aerosol generator of Claim 5, wherein the third layer comprises a material selected from the group consisting of alumina, zirconia, silica and mixtures thereof.
9. The aerosol generator of Claim 1, wherein the first layer comprises a material selected from the group consisting of alumina, zirconia, silica and mixtures thereof.
10. The aerosol generator of Claim 1, wherein the second layer comprises a material selected from the group consisting of alumina, zirconia, silica and mixtures thereof.
11. The aerosol generator of Claim 1, wherein the heater is arranged to directly contact the fluid in the fluid passage.
12. The aerosol generator of Claim 1, wherein the heater is arranged to conduct heat, through the first and/or second layer, to the fluid in the fluid passage.
13. The aerosol generator of Claim 1, wherein the heater comprises a material selected from the group consisting of platinum, titanium nitride, stainless steel, nickel chromium, aluminum or alloy thereof, iron or alloy thereof, iron or titanium aluminide, titanium or alloy thereof, tungsten or alloy thereof, and mixtures thereof.
14. The aerosol generator of Claim 1, further comprising a second heater, wherein the heater is disposed upon the first layer and the second heater is disposed upon the second layer.
15. The aerosol generator of Claim 1, wherein the heater is sputtered, printed, adhesively bonded or coated on the first and/or second layer.
16. The aerosol generator of Claim 1, wherein the fluid passage is a linear passage.
17. The aerosol generator of Claim 1, wherein the fluid passage is a non-linear passage, a tapered passage, and/or a segmented passage wherein the flow passage has different sized cross sections.
18. The aerosol generator of Claim 1, wherein the heater is in electrical contact with first and second contacts which pass an electrical current through the heater, and wherein the volatilized fluid is ejected from the fluid passage when the electrical current is passed through the heater.
19. The aerosol generator of Claim 18, wherein the first and second contacts comprise copper or alloy thereof, gold or alloy thereof, or silver or alloy thereof.
20. The aerosol generator of Claim 1, wherein the fluid comprises a medicated material.
21. The aerosol generator of Claim 1, further comprising a power supply for heating the heater.
22. The aerosol generator according to Claim 1, wherein the fluid passage contains from about 0.000001 ml to 0.005 ml of fluid.
23. The aerosol generator according to Claim 1, wherein the outlet extends through a surface of the first or second layer.
24. The aerosol generator according to Claim 1, further comprising a chamber connected to receive the fluid in liquid phase from the fluid supply and to provide the fluid to the fluid passage, wherein the chamber contains a predetermined amount of the fluid in liquid phase.
25. The aerosol generator according to Claim 1, wherein the heater comprises a uniformly thick layer of resistance heating material having a rectangular or tapered shape, a uniformly thick layer of resistance heating material having a plurality of discrete segments, a layer of resistance heating material which varies in thickness, or a layer of resistance heating material which varies in width.
26. A method for generating an aerosol, comprising the steps of:
(a) supplying fluid to a fluid passage arranged between a first and a second layer, wherein the first and second layers at least partially define the fluid passage and a heater is arranged to volatilize the fluid in the fluid passage and supply the volatilized fluid to an outlet which directs the volatilized fluid out of the fluid passage;
(b) heating the heater so as to volatilize the fluid in the fluid passage; and (c) directing the volatilized fluid out of the fluid passage via the outlet.
27. The method of Claim 26, wherein the heater heats the fluid in the fluid passage by thermal conduction.
28. The method of Claim 26, wherein the heater heats the fluid by thermal conduction through the first and/or second layer.
29. The method of Claim 26, wherein the fluid passage comprises a channel disposed in the first and/or second layers and the volatilised fluid is ejected through an opening in a surface of the first and/or second layers.
CA002432241A 2000-12-22 2001-12-07 Aerosol generator having heater in multilayered composite and method of use thereof Expired - Lifetime CA2432241C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US09/742,320 2000-12-22
US09/742,320 US6701921B2 (en) 2000-12-22 2000-12-22 Aerosol generator having heater in multilayered composite and method of use thereof
PCT/US2001/045759 WO2002051469A2 (en) 2000-12-22 2001-12-07 Aerosol generator having heater in multilayered composite and method of use thereof

Publications (2)

Publication Number Publication Date
CA2432241A1 true CA2432241A1 (en) 2002-07-04
CA2432241C CA2432241C (en) 2009-11-24

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Family Applications (1)

Application Number Title Priority Date Filing Date
CA002432241A Expired - Lifetime CA2432241C (en) 2000-12-22 2001-12-07 Aerosol generator having heater in multilayered composite and method of use thereof

Country Status (11)

Country Link
US (2) US6701921B2 (en)
EP (1) EP1345642B1 (en)
JP (1) JP4383741B2 (en)
AR (1) AR032383A1 (en)
AU (1) AU2002239457A1 (en)
CA (1) CA2432241C (en)
MY (1) MY138968A (en)
PT (1) PT1345642T (en)
TR (1) TR201903437T4 (en)
TW (1) TW524700B (en)
WO (1) WO2002051469A2 (en)

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