CA2432081A1 - Aerosol generator having multiple heating zones and methods of use thereof - Google Patents
Aerosol generator having multiple heating zones and methods of use thereof Download PDFInfo
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- CA2432081A1 CA2432081A1 CA002432081A CA2432081A CA2432081A1 CA 2432081 A1 CA2432081 A1 CA 2432081A1 CA 002432081 A CA002432081 A CA 002432081A CA 2432081 A CA2432081 A CA 2432081A CA 2432081 A1 CA2432081 A1 CA 2432081A1
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- Prior art keywords
- zone
- heater
- flow passage
- aerosol generator
- tube
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M11/00—Sprayers or atomisers specially adapted for therapeutic purposes
- A61M11/04—Sprayers or atomisers specially adapted for therapeutic purposes operated by the vapour pressure of the liquid to be sprayed or atomised
- A61M11/041—Sprayers or atomisers specially adapted for therapeutic purposes operated by the vapour pressure of the liquid to be sprayed or atomised using heaters
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M11/00—Sprayers or atomisers specially adapted for therapeutic purposes
- A61M11/04—Sprayers or atomisers specially adapted for therapeutic purposes operated by the vapour pressure of the liquid to be sprayed or atomised
- A61M11/041—Sprayers or atomisers specially adapted for therapeutic purposes operated by the vapour pressure of the liquid to be sprayed or atomised using heaters
- A61M11/042—Sprayers or atomisers specially adapted for therapeutic purposes operated by the vapour pressure of the liquid to be sprayed or atomised using heaters electrical
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M15/00—Inhalators
- A61M15/02—Inhalators with activated or ionised fluids, e.g. electrohydrodynamic [EHD] or electrostatic devices; Ozone-inhalators with radioactive tagged particles
- A61M15/025—Bubble jet droplet ejection devices
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M11/00—Sprayers or atomisers specially adapted for therapeutic purposes
- A61M11/006—Sprayers or atomisers specially adapted for therapeutic purposes operated by applying mechanical pressure to the liquid to be sprayed or atomised
- A61M11/007—Syringe-type or piston-type sprayers or atomisers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2205/00—General characteristics of the apparatus
- A61M2205/33—Controlling, regulating or measuring
- A61M2205/3368—Temperature
- A61M2205/3372—Temperature compensation
Abstract
A temperature and flow rate controlled capillary aerosol generator includes two heating zones (Z1, Z2) optionally separated by a region in which a pressure drop is induced. Power is metered or applied to the downstream, second zone (Z2) to achieve a target resistance, and a target temperature, while power is metered or applied to the upstream, first zone (Z1) to achiev e a target mass flow rate exiting the second zone. A target temperature is achieved in the second zone to generate an aerosol from the liquid flowing through the generator at the desired mass flow rate.
Description
AEROSOL GENERATOR HAVING MULTIPLE HEATING
ZONES AND METHODS OF USE THEREOF
Field of the Invention The present invention relates generally to aerosol generators and, more particularly, to aerosol generators able to generate aerosols without compressed gas propellants and methods of malting and using such aerosol generators.
Brief Description of the Related Art Aerosols are useful in a wide variety of applications. For example, it is often desirable to treat respiratory ailments with, or deliver drugs by means of, aerosol sprays of finely divided particles of liquid and/or solid, e.g., powder, medicaments, etc., which are inhaled into a patient's lungs. Aerosols are also used for purposes such as providing desired scents to rooms, distributing insecticides and delivering paint and lubricant.
Various techniques are knovcnz for generating aerosols. For example, U.S.
Patent Nos. 4,811,731 and 4,627,432 both disclose devices for administering medicaments to patients in which a capsule is pierced by a pin to release a medicament in powder form. A user then inhales the released medicament through an opening in the device. While such devices may be acceptable for use in delivering medicaments in powder form, they are not suited to delivering medicaments in liquid form. The devices are also, of course, not well-suited to delivery of medicaments to persons who might have difficulty in generating a sufficient flow of air through the device to properly inhale the medicaments, such as asthma sufferers. The devices are also not suited for delivery of materials in applications other than medicament delivery.
Another well-known technique for generating an aerosol involves the use of a manually operated pump which draws liquid from a reservoir and forces it through a small nozzle opening to form a fme spray. A disadvantage of such aerosol generators, at least in medicament delivery applications, is the difficulty of properly synchronizing iWalation with pumping. More importantly, however, because such aerosol generators tend to produce particles of large size, their use as inhalers is compromised because large particles tend to not penetrate deep into the lungs.
One of the more popular techniques for generating an aerosol including liquid or powder particles involves the use of a compressed propellant, often containing a chloro-fluoro-carbon (CFC) or methylchloroform, to entrain a material, usually by the Venturi principle. For example, inhalers containing compressed propellants such as compressed gas for entraining a medicament are often operated by depressing a button to release a short charge of the compressed propellant.
The propellant entrains the medicament as the propellant flows over a reservoir of the medicament so that the propellant and the medicament can be inhaled by the user.
hl propellant-based arrangements, however, a medicament may not be properly delivered to the patient's lungs when it is necessary for the user to time the depression of an actuator such as a button with inhalation. Moreover, aerosols generated by propellant-based arrangements may have particles that are too large to ensure efficient and consistent deep lung penetration. Although propellant-based aerosol generators have wide application for uses such as antiperspirant and deodorant sprays and spray paint, their use is often limited because of the well-l~nown adverse environmental effects of CFC's and methylchloroform, which are among the most popular propellants used in aerosol generators of this type.
In drug delivery applications, it is typically desirable to provide an aerosol having average mass median particle diameters of less than 2 microns to facilitate deep lung penetration. Most l~nown aerosol generators are incapable of generating aerosols having average mass median particle diameters less than 2 microns. It is also desirable, in certain drug delivery applications, to deliver medicaments at high flow rates, e.g., above 1 milligram per second. Most l~nown aerosol generators suited for drug delivery are incapable of delivering such high flow rates in the 0.2 to 2.0 micron size range.
U.S. Patent No. 5,743,251, which is hereby incorporated by reference in its entirety, discloses an aerosol generator, along with certain principles of operation and materials used in an aerosol generator, as well as a method of producing an aerosol, and an aerosol. The aerosol generator disclosed according to the '251 patent is a significant improvement over earlier aerosol generators, such as those used as inhaler devices. It is desirable to produce an aerosol generator that is portable and easy to use.
The invention provides a capillary aerosol generator comprising a flow passage having an inlet, an outlet, a first heater in heat transfer communication with a first zone of the flow passage adjacent the inlet, a second heater in heat transfer communication with a second zone of the flow passage adjacent the outlet, and an optional flow constriction in the flow passage between the first zone and the second zone.
The invention also provides a process of forming an aerosol from a liquid, comprising the steps of supplying pressurized liquid to an upstream end of a flow passage of an aerosol generator including a first heater positioned in heat transfer communication with a first zone of the flow passage, a second heater positioned in heat transfer communication with a second zone of the flow passage and an optional flow constrictor in the flow passage between the first zone and the second zone;
measuring a parameter indicative of the mass flow rate of the fluid flowing through the second zone; changing the temperature in the first zone based on the measurement of the mass flow rate of the fluid through the second zone; axed heating the liquid in the second zone such that the liquid is volatilized and after exiting from a downstream end of the flow passage forms an aerosol.
ZONES AND METHODS OF USE THEREOF
Field of the Invention The present invention relates generally to aerosol generators and, more particularly, to aerosol generators able to generate aerosols without compressed gas propellants and methods of malting and using such aerosol generators.
Brief Description of the Related Art Aerosols are useful in a wide variety of applications. For example, it is often desirable to treat respiratory ailments with, or deliver drugs by means of, aerosol sprays of finely divided particles of liquid and/or solid, e.g., powder, medicaments, etc., which are inhaled into a patient's lungs. Aerosols are also used for purposes such as providing desired scents to rooms, distributing insecticides and delivering paint and lubricant.
Various techniques are knovcnz for generating aerosols. For example, U.S.
Patent Nos. 4,811,731 and 4,627,432 both disclose devices for administering medicaments to patients in which a capsule is pierced by a pin to release a medicament in powder form. A user then inhales the released medicament through an opening in the device. While such devices may be acceptable for use in delivering medicaments in powder form, they are not suited to delivering medicaments in liquid form. The devices are also, of course, not well-suited to delivery of medicaments to persons who might have difficulty in generating a sufficient flow of air through the device to properly inhale the medicaments, such as asthma sufferers. The devices are also not suited for delivery of materials in applications other than medicament delivery.
Another well-known technique for generating an aerosol involves the use of a manually operated pump which draws liquid from a reservoir and forces it through a small nozzle opening to form a fme spray. A disadvantage of such aerosol generators, at least in medicament delivery applications, is the difficulty of properly synchronizing iWalation with pumping. More importantly, however, because such aerosol generators tend to produce particles of large size, their use as inhalers is compromised because large particles tend to not penetrate deep into the lungs.
One of the more popular techniques for generating an aerosol including liquid or powder particles involves the use of a compressed propellant, often containing a chloro-fluoro-carbon (CFC) or methylchloroform, to entrain a material, usually by the Venturi principle. For example, inhalers containing compressed propellants such as compressed gas for entraining a medicament are often operated by depressing a button to release a short charge of the compressed propellant.
The propellant entrains the medicament as the propellant flows over a reservoir of the medicament so that the propellant and the medicament can be inhaled by the user.
hl propellant-based arrangements, however, a medicament may not be properly delivered to the patient's lungs when it is necessary for the user to time the depression of an actuator such as a button with inhalation. Moreover, aerosols generated by propellant-based arrangements may have particles that are too large to ensure efficient and consistent deep lung penetration. Although propellant-based aerosol generators have wide application for uses such as antiperspirant and deodorant sprays and spray paint, their use is often limited because of the well-l~nown adverse environmental effects of CFC's and methylchloroform, which are among the most popular propellants used in aerosol generators of this type.
In drug delivery applications, it is typically desirable to provide an aerosol having average mass median particle diameters of less than 2 microns to facilitate deep lung penetration. Most l~nown aerosol generators are incapable of generating aerosols having average mass median particle diameters less than 2 microns. It is also desirable, in certain drug delivery applications, to deliver medicaments at high flow rates, e.g., above 1 milligram per second. Most l~nown aerosol generators suited for drug delivery are incapable of delivering such high flow rates in the 0.2 to 2.0 micron size range.
U.S. Patent No. 5,743,251, which is hereby incorporated by reference in its entirety, discloses an aerosol generator, along with certain principles of operation and materials used in an aerosol generator, as well as a method of producing an aerosol, and an aerosol. The aerosol generator disclosed according to the '251 patent is a significant improvement over earlier aerosol generators, such as those used as inhaler devices. It is desirable to produce an aerosol generator that is portable and easy to use.
The invention provides a capillary aerosol generator comprising a flow passage having an inlet, an outlet, a first heater in heat transfer communication with a first zone of the flow passage adjacent the inlet, a second heater in heat transfer communication with a second zone of the flow passage adjacent the outlet, and an optional flow constriction in the flow passage between the first zone and the second zone.
The invention also provides a process of forming an aerosol from a liquid, comprising the steps of supplying pressurized liquid to an upstream end of a flow passage of an aerosol generator including a first heater positioned in heat transfer communication with a first zone of the flow passage, a second heater positioned in heat transfer communication with a second zone of the flow passage and an optional flow constrictor in the flow passage between the first zone and the second zone;
measuring a parameter indicative of the mass flow rate of the fluid flowing through the second zone; changing the temperature in the first zone based on the measurement of the mass flow rate of the fluid through the second zone; axed heating the liquid in the second zone such that the liquid is volatilized and after exiting from a downstream end of the flow passage forms an aerosol.
Still other objects, features, and attendant advantages of the present invention will become apparent to those slcilled in the art from a reading of the following detailed description of embodiments constructed in accordance therewith, taken in conjunction with the accompanying drawings.
The invention of the present application will now be described in more detail with reference to preferred embodiments of the apparatus and method, given only by way of example, and with reference to the accompanying drawings, in which:
FIG. 1 schematically illustrates an inhaler incorporating a multi-zone heating apparatus in accordance with the invention;
FIG. 2 schematically illustrates an exemplary capillary aerosol generator (CAG) system in accordance with the present invention;
FIG. 3 schematically illustrates another embodiment of a portion of the CAG
illustrated in FIG. 2;
FIG. 4 schematically illustrates another embodiment of a portion of the CAG
illustrated in FIG. 2;
FIG. 5 schematically illustrates another embodiment of a portion of the CAG
illustrated in FIG. 2;
FIG. 6 schematically illustrates an exemplary control scheme for a CAG in accordance with the present invention;
FIG. 7 schematically illustrates another exemplary control scheme for a CAG
in accordance with the present invention;
FIG. 8 is a graph of power as a function of feed pressure of propylene glycol;
FIG. 9 is a graph of aerosol mass delivery for propylene glycol in a single heating zone as a function of feed pressure of propylene glycol;
FIG. 10 is a graph of power as a function of feed pressure for a dovnnlstream heater, upstream heater and both heaters; and FIG. 11 is a graph of aerosol mass delivery for propylene glycol in a two zone heater as a function of feed pressure of propylene glycol.
-S-nFSCRIPTION OF TH , PRFEERRFD EMBODIMENTS
When referring to the drawing figures, life reference numerals designate identical or corresponding elements throughout the several figures.
According to one aspect of the present invention, a capillary aerosol generator incorporates two heated zones. Each zone is heated by applying a voltage across a resistive element. The resistive elements may be film heaters, such as Pt heaters, applied to a supporting structure through which the fluid flows, e.g., flow chambers such as cylindrical or rectangular flow passages incorporating the film heaters. Fluid can be supplied to the generator, preferably at a substantially constant pressure, fiom a fluid source upstream of the generator. Alternatively, the fluid can be supplied at constant linear displacement rate by a syringe pump. The purpose of the second zone is to vaporize the fluid as it is transported through the tube and after exiting the tube forms an aerosol. Temperature in either heating zone can be measured directly by thermocouples or calculated based on measurement of a parameter such as the resistance of the heating element.
The resistive heating element of the second zone has a suitable temperature coefficient (positive or negative) of resistance, which is preferably a high coefficient of resistance. The second zone is heated by the application of power to the resistive element while the resistance across the element is monitored. The monitored resistance can provide an indication of the temperature of the heating element because the resistance of the heating element varies as a function of its temperature.
For example, if the resistance heater is made of platinum, the temperature coefficient of resistance of platinum is 0.00392 (°C)-'. Using the relationship R=Ro[1+a(T-To)], which defines the resistance value R where Ro is the resistance at Temperature To and T is the temperature for which R is calculated, a platinum heater having a resistance of 5 ohms at 0 ° C, the resistance of the heater will vary linearly from about 0.55 ohms at 20 °C to about 0.9 at 200°C. Thus, by controlling power to a target resistance, the heater can be maintained at a precise target temperature and thereby minimize the possibility pf thermally degrading the fluid or fluids being heated.
The resistance of the second zone's heater element can be fed bacl~ in a control scheme to meter power to the second zone, so that by metering the power to the second zone a target resistance of the second zone heater element is achieved, and therefore the average temperature of the second zone's heater element can be maintained at a target value. At the same time, the power supplied to the second heater element is measured. This power usage data is a measure of the mass flow rate of liquid to and through the second zone, and therefore through the generator as a whole. In tlus way, power monitoring at the second zone serves as a mass flow meter of the fluid flowing through the generator.
According to another aspect of the invention, it is possible to control an aerosol generator to deliver a target total mass (e.g., a dose) of volatilized fluid. In particular, a multi-zone heating arrangement in accordance with the invention can provide a mass flow rate through the heating arrangement which is proportional to the power usage of the heating arrangement. Further, with such a heating arrangement, a total mass (e.g., dose) can be made to be proportional to the total energy used by the heating arrangement. In a medical inhaler, control of the actual dose can be obtained by controlling the fluid flow rate based on a target power level which can be achieved by timing the period of power supply to attain the desired total energy level. Alternatively, a target total energy level can be selected and the fluid flow rate can be adjusted to achieve that target energy level in a present time.
As discussed briefly above, constant pressure fluid is preferably supplied to the upstream, first zone of the generator. The rate at which liquid is delivered from the first heating zone to the second heating zone is dependent upon the pressure drop across the entire fluid channel downstream of the pressure source. According to yet another aspect of the present invention, a segment of small bore tubing, a porous pressure drop element, or other element which functions to throttle fluid flow, is positioned between the outlet of the first zone and the inlet of the second zone. The pressure drop across this element is designed to be a large fraction of the pressure drop across the entire fluid channel downstream of the pressure source and is a function of or depends upon the viscosity of the liquid, which in turn depends upon _7_ the temperature of the fluid. The application of power to the first zone is controlled to control this temperature and thus the liquid flow rate through the first zone.
Power applied to the first zone is controlled to achieve a target power usage in the downstream, second zone, required to maintain the second zone's heater element at a target temperature. In this manner, power control in the first zone serves as a mass flow controller of fluid flowing through both of the first and second zones and therefore the generator as a whole.
The feedback control scheme implemented is designed so that a target flow rate through the generator is achieved when the temperature of the liquid exiting the first zone is at a target temperature above the highest anticipated ambient temperature in which the generator would be used. In this way, the mass flow rate can be controlled to its target value independent of ambient temperature and independent of the pressure applied to the liquid, because the temperature of the liquid entering the second zone is substantially the same across a wide range of ambient enviromnental temperatures and because the source of fluid supplies the fluid at a substantially constant pressure. A generator according to the present invention therefore is capable of reducing the likelihood of overheating the liquid, and controlling the aerosol delivery rate in the presence of variations in ambient temperature and pressure applied to the liquid.
One object of the present invention is to provide controlled heating along the length of the capillary tube used to heat and vaporize a flowing liquid inside the tube. There are numerous benefits which can be achieved through the use of this approach to heating. As overheating the fluid is not desirable and if sections of the tube walls become too hot due to localized vaporization or bubbles in the liquid stream, the liquid materials may be thermally degraded. The present invention instead provides multiple heated areas which can be easily monitored ayd readily react to a control scheme. Furthermore, a generator according to the present invention is thus capable of compensating for materials which are not delivered to the tube at optimum temperatures. Further, a generator according to the present invention is capable of reacting to or accommodating changes in flow rates and _g_ liquid density inside the tube after the fluid has been introduced into the generator, and the several heating segments can actively respond to the output of sensors independent of the other segments.
According to a first exemplary embodiment, a capillary aerosol generator comprises a capillary tube having a inlet port, an outlet port, aald a lumen extending through the tube from the inlet port to the outlet port, a first heater in heat transfer communication with a first zone of the tube adjacent to the inlet port, a second heater in heat transfer cormnunication with a second zone of the tube adj acent to the outlet port, a flow constriction in the tube lumen between the first zone and the second zone.
According to a second exemplary embodiment, a process of forming an aerosol from a liquid comprises the steps of providing an aerosol generator including a tube, a first heater positioned in heat transfer communication with a first, upstream zone of the tube, a second heater positioned in heat transfer communication with a second, downstream zone of the tube, and a flow constrictor in the tube between the first zone and the second zone, supplying the liquid at a pressure to an upstream end of the tube, measuring a characteristic of the tube indicative of the mass flow rate of the fluid flowing through the tube in the second zone, changing the temperature of the tube in the first zone based on the measurement of the mass flow rate of the fluid through the second zone, and allowing the liquid to exit the tube at a downstream end of the tube.
In developing capillary aerosol generators it is desirable to improve control of the rate at which liquid is introduced into the capillary tube and the rate at which power is metered to the capillary tube's heater. Failure to correctly control these parameters can result in overheating of the liquid, resulting in thermal degradation of the liquid material and subsequent clogging of the capillary by the byproducts of this thermal degradation.
One aspect of the present invention is the reduction in the lil~elihood that the liquid in the capillary tube is improperly heated, by controlling the energy supplied to a liquid vaporization zone (a downstream, second heating zone) to achieve a target temperature, while controlling the energy supplied or power metered to a liquid flow rate control zone (an upstream, first zone) to achieve the target liquid flow rate emerging from the aerosol generator. The capillary aerosol generator according to the present invention includes heating elements and associated control circuitry which function as heating elements as well as flow meters and flow controllers.
According to a preferred embodiment, the present invention provides a capillary aerosol generator which includes a system for heating an essentially hollow, tubular structure using a series of heated zones to allow for different temperatures and rates of heating along the length of the tubular structure.
The system includes a series of discrete heating elements along the length of the structure, or alternative arrangement such as by segmenting a continuous resistive heater using independent contacts along the length of the resistor. The resistive array of single resistive elements can have purposeful spacing between the heated sections and incorporate current, voltage, and/or temperature sensing devices along the tube length that can passively sense or be part of an active control system. The control system activates the individual heaters with a sequence of currents, voltages, or both, which delivers electrical power to the tube. Additionally, the control system can interact with and react to one or more of the sensors. Alternatively, the heaters can be inductive heaters instead of resistive heaters. The heater materials can be an integral part of the tube's walls or independent elements added to the structure.
FIG. 1 shows an inhaler 500 incorporating a mufti-zone heater 510 in accordance with the invention. The inhaler 500 includes a first housing 520 having a mouthpiece 522 and second housing 530 which includes power source and logic circuitry as discussed in copending Application Serial No. 09/172,023, filed October 14, 1998, the disclosure of which is hereby incorporated by reference. An aerosol is generated by a heated tube 540 incorporating the mufti-zone heater 510. Liquid from a pressurized source 550 passes through a valve 560 and into a first heated zone Z1 of the tube 540 and the vapor is generated in a second zone Z2 of the tube 540. The vapor mixes with air inside the housing 520 to form an aerosol and the resulting mixture can be inhaled through the mouthpiece 522.
FIG. 2 schematically illustrates an exemplary capillary aerosol generator (CAG) system 600 in accordance with the present invention. CAG system 600 includes a source of pressurized fluid 604, a CAG 602, and a valve 606. Valve controls the flow of pressurized fluid from source 604 to CAG 602, and can be controlled either manually or, more preferably, under control of a controller, as described in greater detail below. A controller 608 is also provided for controlling the operation of CAG 602, and optionally also controls valve 606. Valve 606 can alternatively be controlled by a separate controller (not illustrated).
CAG 602 is divided into at least two heating zones: an upstream, first zone Zl; and a downstream, second zone Z2. The two zones can be optionally separated by an intermediate zone Z3. Each of zones Z1, Z2 includes an electrical heating element which heats up upon the application of a voltage across and current through the heating element, as will be readily appreciated by one of ordinary slcill in the art.
Controller 608 is placed in electrical communication with and across both zones Z1 and Z2, as illustrated in FIG. 2, and selectively applies voltage across and current through the heaters in the zones. Controller 608 can be provided with a memory in which an instruction set for operation of the controller can be stored.
Controller 608 can be a general purpose digital computer which operates under software control, the set of software instructions being stored in volatile or non-volatile memory 610, or optionally and alternatively controller 608 can be a specially constructed, expert controller including discrete digital or analog components which together embody the instruction set for controller 608. As the specific construction of controller 608 will be readily appreciated by one of ordinary skill in the art upon a complete reading of the descriptions herein, no further description of the specific design of controller 608 will be undertaken.
FIG. 3 illustrates another embodiment of a CAG in accordance with the present invention, CAG 612. CAG 612 includes a first, upstream tube 614 and a second, downstream tube 616. First tube 614 includes a proximal inlet 618, a flow passage 620, and a distal outlet 622. Inlet 618 is in fluid communication with source 604, as described above, and directs a fluid, preferably a liquid, along a fluid flowpath 624 downstream to outlet 622. Second tube 616 is positioned downstream of outlet 622, and includes a proximal inlet 626, a flow passage 628, and a distal outlet 630. As illustrated in FIG. 3, first tube 614 has a fluid flow cross section which is greater than the fluid flow cross section of second tube 616, and inlet 626 is positioned at outlet 622, i.e., there are no structures between inlet 626 and outlet 622.
First tube 614 and second tube 616 include a heater element or elements therein or thereon to which controller 608 is electrically connected. The heaters can be made integral with the tubes, such as by forming the tubes themselves of a material which is sufficiently electrically resistive to act as an electrical heater for the fluid contents of the tube. Alternatively, tubes 614, 616 can include one or more internal or external heaters mounted to the tubes which heat when a voltage is applied to them, and which in turn heat the tubes and their fluid contents.
Controller 608, in accordance with the instruction set contained in memory 610 or the logic of its discrete elements, selectively applies a voltage to the heater associated with one or both of tubes 614, 616. The voltage applied causes the heater elements) to increase in temperature, which in turn heats the fluid contents of the respective tube by convection and/or conduction. As described in greater detail herein, one or both of tubes 614, 616 and their fluid contents can be selectively heated. At the same time, a parameter such as resistance of the heater element heating the tube 614 can be measured to monitor the temperature of the tube 616 and the power used to heat the tube 616 can be measured to determine the mass flow rate of fluid flowing through the CAG.
As outlet 630 is the port from which vaporized fluid exits CAG 612, it is preferable that outlet 630 is unobstructed so that the flow of fluid out of CAG 612 is not impeded at outlet 630. Furthermore, by providing a zone of reduced cross section downstream of the first tube 614, a throttle is formed which induces a pressure drop. This optional throttle or other constriction which causes a drop in fluid pressure in CAG 612 is located downstream of first tube 614 and is substantially confined to zone Z3 (see FIG. 2). By forming a structure in CAG
which induces or causes a drop in fluid pressure in the flow passages of tubes 614, 616, it is possible to control the mass flow rate of fluid flowing through the CAG. It is therefore preferable that tubes 614, 616 include no or substantially no source of a reduction in fluid pressure along their lengths, so that the mass flow rate of fluid through the CAG can be determined and maintained at a desired level by controller 608.
FIG. 2 and FIG. 3 illustrate that controller 608 is electrically connected to first tube 614 to define first zone Z1, and electrically connected to second tube 616 to define second zone Z2. CAG 612, as with other embodiments of CAG 602 described herein, may optionally include a temperature sensing device 632 attached to or formed in the distal end of second tube 616. Temperature sensor 632 can be a thermistor or other temperature sensitive device which can provide a signal which includes data representative of the temperature of the distal end of second tube 616.
Temperature sensor 632 can be in electrical communication with controller 608 so as to provide a signal indicative of the temperature of the distal end of second tube 616 to the controller to provide a feedback signal for controlling the application of power to first tube 614, second tube 616, or both, as described in greater detail below.
Turning now to FIG. 4, yet another embodiment of CAG 602, CAG 640, is illustrated. CAG 640 is similar in many respects to CAG 612, except that CAG
is formed as a monolithic, integral, unitary structure formed as a single piece. A
first, proximal, upstream portion 642 receives pressurized fluid from source 604, as described above. An optional flow constrictor 644 is formed distally downstream of portion 642, and creates a drop in fluid pressure. A second, distal portion 646 is formed downstream of constrictor 644, and includes a distal exit port 648 from which vaporized fluid exits CAG 640. Thus, zone Z1 includes portion 642, zone includes portion 646, and zone Z3 includes constrictor 644. As in CAG 612, the heater elements for each of portions 642, 646 can be a portion of the walls of the CAG, attached to the walls of the GAG, or combinations thereof.
FIG. 5 schematically illustrates yet another embodiment, CAG 660. Similar to CAG 640, CAG 660 is preferably formed from a single piece of material and is electrically connected to controller 608 to define zones Z1, Z2, and Z3, as described above. Different from CAGs 612, 640, CAG 660 has a constant internal flow cross-sectional area in zones Zl and Z2, and an optional constrictor 662 is mounted or otherwise provided in zone Z3 to cause a drop in fluid pressure. Preferably, constrictor 662 is a porous plug formed of a material non-reactive to the fluid intended to flow through CAG 660, and includes pores therein which allow the fluid to flow through the plug and the CAG. Constrictor 660 is designed to provide a drop in fluid pressure between zones Z1 and Z2 at a predetermined fluid pressure and viscosity, in a manner well appreciated by one of ordinary skill in the art.
The function of controller 608 with CAG 612, 640, or 660 will now be described with reference to FIG. 6. Throughout this description, several variables will be discussed, as follows:
V(Z1).................voltage across zone Z1 V(Z2). ................voltage across zone P(Z1).. ...............electrical power used in zone Z1 P(Z2).. ...............electrical power used in zone Z2 T(Z1).................average temperature of CAG in zone Zl T(Z2).................average temperature of CAG in zone Z2 T(Z3).................average temperature of CAG in zone Z3 T(Z2') ................temperature of CAG at distal end of zone Z2 r(Zl)... ...............electrical resistance of portion of CAG in zone Zl r(Z2)... ...............electrical resistance of portion of CAG in zone Z2 M......................mass flow rate of fluid M(Z1)...............mass flow rate of fluid flowing through zone Z1 M(Z2)...............mass flow rate of fluid flowing through zone Z2 pr(Z1)...............fluid pressure drop across zone Z1 pr(Z2)...............fluid pressure drop across zone Z2 pr(Z3)...............fluid pressure drop across zone Z3 r~.......................fluid viscosity From the foregoing description, because there is no loss of fluid in the CAG
between zones Zl and Z2, the mass flow rates through these zones are identical, or M(Zl) = M(Z2) = M
As well appreciated by one of ordinary skill in the art, the electrical power (P) of an electrical component, its resistivity (r), the current (i) flowing through the element, and the electrical potential or voltage (V) across the element are interrelated, according to well-known relationships:
V=it P=i2r P=iV
P=VZIr Additionally, because of the design of the CAGs of the present invention, several other relationships can be used to measure and control electrical and physical characteristics of the CAG and the fluid flowing therethrough. It has been found by the inventors herein that the power consumed by the portion of the CAG in zone to maintain that portion of the CAG at a known temperature (the boiling point for the liquid being aerosolized, for example) is a function of the mass flow rate through the CAG:
P(Z2) = F(M) The exact functional relationship between power and mass flow rate can be readily empirically determined, as will be readily apparent to one of ordinary skill in the art.
Once this functional relationship is determined, it is used to form the instruction set in memory 610, or to design the logic of controller 608, as described below.
The materials from which the CAGs are formed, along with the heater elements themselves, are selected so that the average temperatures of zones Z1 and Z2 are functions of the resistance of the portions of the CAGs which are in these zones:
T(Z1) = F(r(Z1)) and T(Z2) = F(r(Z2)) Many materials, e.g., copper, stainless steel, and platinum, exhibit this relationship between temperature and resistance, and the function is linear over a wide range of temperatures. Thus, the material out of which the CAGs are formed, or at least the heater elements, is preferably selected to have a temperature-resistance function which is well l~nown, and preferably linear, over the range of temperatures in which system 600 will be used and the fluid will be aerosolized at least in the case where the resistance of the heater element is used to measure the temperature of the tube.
The CAG is preferably designed so that when controller 608 attempts to maintain the power consumed by the portion of the CAG in zone Z2 at its target level, P (target), the temperature of zone Z1 will be at a level, which is preferably at or slightly above the highest ambient temperature at which it is anticipated that system 600 would be used.
Additionally, the fluid to be aerosolized is preferably delivered to zone Zl by applying a constant pressure P. The fluid pressure drops across zones Z1 and Z2 are preferably close to zero:
pr(Z1) ~ pr(Z2) ~ 0 in which case:
P ~ pr(Z3) Furthermore, the pressure drop across zone Z3 is related to the mass flow rate of the fluid flowing through the CAG and the viscosity, eta, of the fluid in zone Z3, according to the relationship:
pr(Z3) =1~*M/eta where 1~ is a constant dependent upon the geometry of the channel in zone (Z3) and eta is the viscosity of the fluid in this zone, which viscosity is a function of the temperature of the fluid, that is:
eta = F(T(Z3)) Therefore:
P ~- 1~*M/eta or M ~ P*eta/k Thus, the mass flow rate of fluid through the CAG is determined by the applied pressure and the viscosity of the fluid in zone Z3. This latter quantity is, in turn, controlled by the temperature in zone Z3. It is for this reason that the flow constrictor is preferably provided, i.e., so that the mass flow rate can be more accurately controlled by adjusting the temperature in zone Z3.
These several functional interrelationships having been established, an exemplary control scheme for controller 608 will now be described with reference to FIG. 6. At the initiation of a cycle of generating a predetermined amount or bolus of aerosolized liquid, valve 606 is opened, allowing liquid at a known and preferably constant pressure to enter the CAG. At step 700, controller 608 applies and controls voltages across Z1 and Z2 to raise the temperature of the fluid therein. At step 702, the controller measures resistance r(Z2), to measure T(Z2). Alternatively, or as a redundant measurement, the controller measures T(Z2') at step 704 at the exit of zone Z2 with the thermocouple or thermistor. At step 706, the controller then compares the measured value of T(Z2), and adjusts V(Z2), and therefore P(Z2), to achieve a measured, target r(Z2), and therefore a target T(Z2). As will be readily appreciated by one of ordinary skill in the art, the temperature achieved can be within a predetermined range and still satisfy this condition, i.e., a certain, predetermined error is acceptable.
The controller then measures P(Z2) at step 708 which was needed to maintain T(Z2) at (or acceptably near) the target value, which gives a measure of the mass flow rate M of fluid flowing through the CAG, as discussed above. At step 710, the controller evaluates if the power measured to maintain the proper temperature, P(Z2), is greater than the power necessary, P(target), from the empirical relationship between power and mass flow rate. If so, the controller decreases the voltage, and therefore the power, applied to zone Z1. This is because when the mass flow rate is higher than desired, the fluid flowing through the CAG
will cool the zone Z2, requiring additional power to heat zone Z2 to the target temperature. A decrease in the voltage applied across zone Z1 lowers the temperature of the fluid therein, and therefore raises the viscosity, and therefore lowers the mass flow rate through zone Z2. This has the effect of malting zone Zl a flow controller for the CAG, and making zone Z2 a flow monitor for the CAG.
Similarly, at step 712 if the power measured across zone Z2 to achieve the target temperature T(Z2) is less than the target power, the controller increases the voltage across (and therefore the power used by) zone Z1 to increase the temperature of the fluid flowing through zone Zl, and thereby raises the mass flow rate.
At step 714, the controller sums or integrates mass flow rate over time to determine the total mass (m) delivered during the cycle. At step 716, the total mass m delivered is compared with a predetermined desired value of m. If the total mass actually delivered is less than the amount desired to be delivered, then the controller returns to step 700. If the total mass delivered is equal to or greater than the total mass desired, the flow of fluid from the source 604 is terminated by valve 606, and the voltages) across zones Z1 and Z2 are set to zero.
FIG. 7 schematically illustrates a control scheme for controller 608 which assists in determining if a fault condition exists in the CAG. The control scheme illustrated in FIG. 7 can be integrated into the control scheme illustrated in FIG. 6 and described with reference thereto, or can precede or follow the control scheme of FIG. 6. In step 730, the power consumed in zone Z2 is measured, which is a .
measure of the mass flow rate through zone Z2. The temperature of zone Z2 is then measured in step 732, either by measuring the resistance of the heater element in zone Z2, or by measuring the temperature T(Z2') at the thermocouple as at step 734.
At step 736, the controller determines whether the power consumption measured at zone Z2 is less than P(target), and the controller increases the voltage across (and therefore the~power consumed by) zone Z1, to increase the mass flow rate M. However, this action may fail to increase P(Z2) to P(target). A power consumption measurement which is low for the temperature measured can be indicative of a blockage in the flow passage of the CAG, which would lower the mass flow rate and the power P(Z2) required to achieve the target T(Z2). In this event, an alarm could be sounded, and the apparatus shut down.
At step 738, the controller determines whether the power consumption measured at zone Z2 is greater than P(target), and the controller decreases the voltage across (and therefore the power consumed by) zone Z1, to decrease the mass flow rate M. However, this action may fail to decrease P(Z2) to P(target). A
power consumption measurement which is high for the temperature measured can be indicative of an overflow condition in the flow passages of the CAG, which would raise the mass flow rate and the power P(Z2) required to achieve the target T(Z2).
In this event, an alarm could be sounded, and the apparatus shut down.
According to the invention, a control algorithm can be used to maintain a downstream heater at a desired target resistance. Once steady state operation is achieved (e.g., in less than 100 msec), the algorithm can calculate the energy consmnption (power) in the downstream heater based on an arbitrary time scan (e.g., 32 msec average). The frequency at which the upstream heater is pulsed can be adjusted up or down as a function of whether the downstream heater is operating at a desired target power. If the power in the downstream heater is below the target level, the time between the upstream heater pulses can be decreased to thereby increase the temperature in the upstream heater zone.
Experiments in which energy consumption and mass delivery are compared as a function of feed pressure are shown in Figures 8 and 9 wherein Figure 8 shows power as a function of feed pressure of propylene glycol in the case where the upstream heater is turned off, the run time is 10 seconds and the downstream resistance target is 0.36 ohms. Figure 9 shows aerosol mass delivery under the same conditions as used in Figure 8. Thus, Figures 8 and 9 show typical one heating zone response to increasing feed pressure. As shown, the power usage and aerosol mass increase in a linear fashion with increasing pressure.
In two-zone experiments, the downstream heater target power level was 2.6 watts, the upstream heater was turned off, and the feed pressure was 20 psi.
The initial setting for the upstream heater was to supply power to the upstream heater once every 8 msec. Further, pressure was varied from 6 to 30 psi and the energy usage and mass deliveries were measured. Figure 10 shows power curves as a function of pressure for the downstream heater, the upstream heater and both heaters, the downstream heater target resistance being set at 0.36 ohms, the downstream heater target power being set at 2.6 watts and the fluid being propylene glycol.
Figure 11 shows the aerosol mass delivery for propylene glycol (PG) in a two-zone heater wherein the run time was 10 seconds, the downstream heater target resistance was 0.36 ohms, the upstream heater firing frequency was once every msec and the downstream heater target power was 2.6 watts. Results for one-zone heating was added to Figure 11 for comparison. As shown, the aerosol mass delivery for the two-zone heating arrangement remains relatively constant over the feed pressure range of 6 to 20 psi. Above 20 psi, the aerosol mass delivery tracl~s the one-zone data because the target power level was set for the 20 psi case and the upstream heater is unable to cool the PG to compensate for an increase in pressure above this target. Accordingly, heating the PG to reduce its viscosity and increase its flow rate can be used to compensate for pressure variations and/or temperature variations. Moreover, these experiments demonstrate that power consumption of the downstream heater can be used as a feedbacl~ signal to control the upstream heater power. In the case illustrated in Figure 1 l, a 32 msec power average was used for the downstream heater and the heating arrangement responded rapidly to achieve the desired targets.
While the invention has been described in detail with reference to preferred embodiments thereof, it will be apparent to one slcilled in the art that various changes can be made, and equivalents employed, without departing from the scope of the invention.
The invention of the present application will now be described in more detail with reference to preferred embodiments of the apparatus and method, given only by way of example, and with reference to the accompanying drawings, in which:
FIG. 1 schematically illustrates an inhaler incorporating a multi-zone heating apparatus in accordance with the invention;
FIG. 2 schematically illustrates an exemplary capillary aerosol generator (CAG) system in accordance with the present invention;
FIG. 3 schematically illustrates another embodiment of a portion of the CAG
illustrated in FIG. 2;
FIG. 4 schematically illustrates another embodiment of a portion of the CAG
illustrated in FIG. 2;
FIG. 5 schematically illustrates another embodiment of a portion of the CAG
illustrated in FIG. 2;
FIG. 6 schematically illustrates an exemplary control scheme for a CAG in accordance with the present invention;
FIG. 7 schematically illustrates another exemplary control scheme for a CAG
in accordance with the present invention;
FIG. 8 is a graph of power as a function of feed pressure of propylene glycol;
FIG. 9 is a graph of aerosol mass delivery for propylene glycol in a single heating zone as a function of feed pressure of propylene glycol;
FIG. 10 is a graph of power as a function of feed pressure for a dovnnlstream heater, upstream heater and both heaters; and FIG. 11 is a graph of aerosol mass delivery for propylene glycol in a two zone heater as a function of feed pressure of propylene glycol.
-S-nFSCRIPTION OF TH , PRFEERRFD EMBODIMENTS
When referring to the drawing figures, life reference numerals designate identical or corresponding elements throughout the several figures.
According to one aspect of the present invention, a capillary aerosol generator incorporates two heated zones. Each zone is heated by applying a voltage across a resistive element. The resistive elements may be film heaters, such as Pt heaters, applied to a supporting structure through which the fluid flows, e.g., flow chambers such as cylindrical or rectangular flow passages incorporating the film heaters. Fluid can be supplied to the generator, preferably at a substantially constant pressure, fiom a fluid source upstream of the generator. Alternatively, the fluid can be supplied at constant linear displacement rate by a syringe pump. The purpose of the second zone is to vaporize the fluid as it is transported through the tube and after exiting the tube forms an aerosol. Temperature in either heating zone can be measured directly by thermocouples or calculated based on measurement of a parameter such as the resistance of the heating element.
The resistive heating element of the second zone has a suitable temperature coefficient (positive or negative) of resistance, which is preferably a high coefficient of resistance. The second zone is heated by the application of power to the resistive element while the resistance across the element is monitored. The monitored resistance can provide an indication of the temperature of the heating element because the resistance of the heating element varies as a function of its temperature.
For example, if the resistance heater is made of platinum, the temperature coefficient of resistance of platinum is 0.00392 (°C)-'. Using the relationship R=Ro[1+a(T-To)], which defines the resistance value R where Ro is the resistance at Temperature To and T is the temperature for which R is calculated, a platinum heater having a resistance of 5 ohms at 0 ° C, the resistance of the heater will vary linearly from about 0.55 ohms at 20 °C to about 0.9 at 200°C. Thus, by controlling power to a target resistance, the heater can be maintained at a precise target temperature and thereby minimize the possibility pf thermally degrading the fluid or fluids being heated.
The resistance of the second zone's heater element can be fed bacl~ in a control scheme to meter power to the second zone, so that by metering the power to the second zone a target resistance of the second zone heater element is achieved, and therefore the average temperature of the second zone's heater element can be maintained at a target value. At the same time, the power supplied to the second heater element is measured. This power usage data is a measure of the mass flow rate of liquid to and through the second zone, and therefore through the generator as a whole. In tlus way, power monitoring at the second zone serves as a mass flow meter of the fluid flowing through the generator.
According to another aspect of the invention, it is possible to control an aerosol generator to deliver a target total mass (e.g., a dose) of volatilized fluid. In particular, a multi-zone heating arrangement in accordance with the invention can provide a mass flow rate through the heating arrangement which is proportional to the power usage of the heating arrangement. Further, with such a heating arrangement, a total mass (e.g., dose) can be made to be proportional to the total energy used by the heating arrangement. In a medical inhaler, control of the actual dose can be obtained by controlling the fluid flow rate based on a target power level which can be achieved by timing the period of power supply to attain the desired total energy level. Alternatively, a target total energy level can be selected and the fluid flow rate can be adjusted to achieve that target energy level in a present time.
As discussed briefly above, constant pressure fluid is preferably supplied to the upstream, first zone of the generator. The rate at which liquid is delivered from the first heating zone to the second heating zone is dependent upon the pressure drop across the entire fluid channel downstream of the pressure source. According to yet another aspect of the present invention, a segment of small bore tubing, a porous pressure drop element, or other element which functions to throttle fluid flow, is positioned between the outlet of the first zone and the inlet of the second zone. The pressure drop across this element is designed to be a large fraction of the pressure drop across the entire fluid channel downstream of the pressure source and is a function of or depends upon the viscosity of the liquid, which in turn depends upon _7_ the temperature of the fluid. The application of power to the first zone is controlled to control this temperature and thus the liquid flow rate through the first zone.
Power applied to the first zone is controlled to achieve a target power usage in the downstream, second zone, required to maintain the second zone's heater element at a target temperature. In this manner, power control in the first zone serves as a mass flow controller of fluid flowing through both of the first and second zones and therefore the generator as a whole.
The feedback control scheme implemented is designed so that a target flow rate through the generator is achieved when the temperature of the liquid exiting the first zone is at a target temperature above the highest anticipated ambient temperature in which the generator would be used. In this way, the mass flow rate can be controlled to its target value independent of ambient temperature and independent of the pressure applied to the liquid, because the temperature of the liquid entering the second zone is substantially the same across a wide range of ambient enviromnental temperatures and because the source of fluid supplies the fluid at a substantially constant pressure. A generator according to the present invention therefore is capable of reducing the likelihood of overheating the liquid, and controlling the aerosol delivery rate in the presence of variations in ambient temperature and pressure applied to the liquid.
One object of the present invention is to provide controlled heating along the length of the capillary tube used to heat and vaporize a flowing liquid inside the tube. There are numerous benefits which can be achieved through the use of this approach to heating. As overheating the fluid is not desirable and if sections of the tube walls become too hot due to localized vaporization or bubbles in the liquid stream, the liquid materials may be thermally degraded. The present invention instead provides multiple heated areas which can be easily monitored ayd readily react to a control scheme. Furthermore, a generator according to the present invention is thus capable of compensating for materials which are not delivered to the tube at optimum temperatures. Further, a generator according to the present invention is capable of reacting to or accommodating changes in flow rates and _g_ liquid density inside the tube after the fluid has been introduced into the generator, and the several heating segments can actively respond to the output of sensors independent of the other segments.
According to a first exemplary embodiment, a capillary aerosol generator comprises a capillary tube having a inlet port, an outlet port, aald a lumen extending through the tube from the inlet port to the outlet port, a first heater in heat transfer communication with a first zone of the tube adjacent to the inlet port, a second heater in heat transfer cormnunication with a second zone of the tube adj acent to the outlet port, a flow constriction in the tube lumen between the first zone and the second zone.
According to a second exemplary embodiment, a process of forming an aerosol from a liquid comprises the steps of providing an aerosol generator including a tube, a first heater positioned in heat transfer communication with a first, upstream zone of the tube, a second heater positioned in heat transfer communication with a second, downstream zone of the tube, and a flow constrictor in the tube between the first zone and the second zone, supplying the liquid at a pressure to an upstream end of the tube, measuring a characteristic of the tube indicative of the mass flow rate of the fluid flowing through the tube in the second zone, changing the temperature of the tube in the first zone based on the measurement of the mass flow rate of the fluid through the second zone, and allowing the liquid to exit the tube at a downstream end of the tube.
In developing capillary aerosol generators it is desirable to improve control of the rate at which liquid is introduced into the capillary tube and the rate at which power is metered to the capillary tube's heater. Failure to correctly control these parameters can result in overheating of the liquid, resulting in thermal degradation of the liquid material and subsequent clogging of the capillary by the byproducts of this thermal degradation.
One aspect of the present invention is the reduction in the lil~elihood that the liquid in the capillary tube is improperly heated, by controlling the energy supplied to a liquid vaporization zone (a downstream, second heating zone) to achieve a target temperature, while controlling the energy supplied or power metered to a liquid flow rate control zone (an upstream, first zone) to achieve the target liquid flow rate emerging from the aerosol generator. The capillary aerosol generator according to the present invention includes heating elements and associated control circuitry which function as heating elements as well as flow meters and flow controllers.
According to a preferred embodiment, the present invention provides a capillary aerosol generator which includes a system for heating an essentially hollow, tubular structure using a series of heated zones to allow for different temperatures and rates of heating along the length of the tubular structure.
The system includes a series of discrete heating elements along the length of the structure, or alternative arrangement such as by segmenting a continuous resistive heater using independent contacts along the length of the resistor. The resistive array of single resistive elements can have purposeful spacing between the heated sections and incorporate current, voltage, and/or temperature sensing devices along the tube length that can passively sense or be part of an active control system. The control system activates the individual heaters with a sequence of currents, voltages, or both, which delivers electrical power to the tube. Additionally, the control system can interact with and react to one or more of the sensors. Alternatively, the heaters can be inductive heaters instead of resistive heaters. The heater materials can be an integral part of the tube's walls or independent elements added to the structure.
FIG. 1 shows an inhaler 500 incorporating a mufti-zone heater 510 in accordance with the invention. The inhaler 500 includes a first housing 520 having a mouthpiece 522 and second housing 530 which includes power source and logic circuitry as discussed in copending Application Serial No. 09/172,023, filed October 14, 1998, the disclosure of which is hereby incorporated by reference. An aerosol is generated by a heated tube 540 incorporating the mufti-zone heater 510. Liquid from a pressurized source 550 passes through a valve 560 and into a first heated zone Z1 of the tube 540 and the vapor is generated in a second zone Z2 of the tube 540. The vapor mixes with air inside the housing 520 to form an aerosol and the resulting mixture can be inhaled through the mouthpiece 522.
FIG. 2 schematically illustrates an exemplary capillary aerosol generator (CAG) system 600 in accordance with the present invention. CAG system 600 includes a source of pressurized fluid 604, a CAG 602, and a valve 606. Valve controls the flow of pressurized fluid from source 604 to CAG 602, and can be controlled either manually or, more preferably, under control of a controller, as described in greater detail below. A controller 608 is also provided for controlling the operation of CAG 602, and optionally also controls valve 606. Valve 606 can alternatively be controlled by a separate controller (not illustrated).
CAG 602 is divided into at least two heating zones: an upstream, first zone Zl; and a downstream, second zone Z2. The two zones can be optionally separated by an intermediate zone Z3. Each of zones Z1, Z2 includes an electrical heating element which heats up upon the application of a voltage across and current through the heating element, as will be readily appreciated by one of ordinary slcill in the art.
Controller 608 is placed in electrical communication with and across both zones Z1 and Z2, as illustrated in FIG. 2, and selectively applies voltage across and current through the heaters in the zones. Controller 608 can be provided with a memory in which an instruction set for operation of the controller can be stored.
Controller 608 can be a general purpose digital computer which operates under software control, the set of software instructions being stored in volatile or non-volatile memory 610, or optionally and alternatively controller 608 can be a specially constructed, expert controller including discrete digital or analog components which together embody the instruction set for controller 608. As the specific construction of controller 608 will be readily appreciated by one of ordinary skill in the art upon a complete reading of the descriptions herein, no further description of the specific design of controller 608 will be undertaken.
FIG. 3 illustrates another embodiment of a CAG in accordance with the present invention, CAG 612. CAG 612 includes a first, upstream tube 614 and a second, downstream tube 616. First tube 614 includes a proximal inlet 618, a flow passage 620, and a distal outlet 622. Inlet 618 is in fluid communication with source 604, as described above, and directs a fluid, preferably a liquid, along a fluid flowpath 624 downstream to outlet 622. Second tube 616 is positioned downstream of outlet 622, and includes a proximal inlet 626, a flow passage 628, and a distal outlet 630. As illustrated in FIG. 3, first tube 614 has a fluid flow cross section which is greater than the fluid flow cross section of second tube 616, and inlet 626 is positioned at outlet 622, i.e., there are no structures between inlet 626 and outlet 622.
First tube 614 and second tube 616 include a heater element or elements therein or thereon to which controller 608 is electrically connected. The heaters can be made integral with the tubes, such as by forming the tubes themselves of a material which is sufficiently electrically resistive to act as an electrical heater for the fluid contents of the tube. Alternatively, tubes 614, 616 can include one or more internal or external heaters mounted to the tubes which heat when a voltage is applied to them, and which in turn heat the tubes and their fluid contents.
Controller 608, in accordance with the instruction set contained in memory 610 or the logic of its discrete elements, selectively applies a voltage to the heater associated with one or both of tubes 614, 616. The voltage applied causes the heater elements) to increase in temperature, which in turn heats the fluid contents of the respective tube by convection and/or conduction. As described in greater detail herein, one or both of tubes 614, 616 and their fluid contents can be selectively heated. At the same time, a parameter such as resistance of the heater element heating the tube 614 can be measured to monitor the temperature of the tube 616 and the power used to heat the tube 616 can be measured to determine the mass flow rate of fluid flowing through the CAG.
As outlet 630 is the port from which vaporized fluid exits CAG 612, it is preferable that outlet 630 is unobstructed so that the flow of fluid out of CAG 612 is not impeded at outlet 630. Furthermore, by providing a zone of reduced cross section downstream of the first tube 614, a throttle is formed which induces a pressure drop. This optional throttle or other constriction which causes a drop in fluid pressure in CAG 612 is located downstream of first tube 614 and is substantially confined to zone Z3 (see FIG. 2). By forming a structure in CAG
which induces or causes a drop in fluid pressure in the flow passages of tubes 614, 616, it is possible to control the mass flow rate of fluid flowing through the CAG. It is therefore preferable that tubes 614, 616 include no or substantially no source of a reduction in fluid pressure along their lengths, so that the mass flow rate of fluid through the CAG can be determined and maintained at a desired level by controller 608.
FIG. 2 and FIG. 3 illustrate that controller 608 is electrically connected to first tube 614 to define first zone Z1, and electrically connected to second tube 616 to define second zone Z2. CAG 612, as with other embodiments of CAG 602 described herein, may optionally include a temperature sensing device 632 attached to or formed in the distal end of second tube 616. Temperature sensor 632 can be a thermistor or other temperature sensitive device which can provide a signal which includes data representative of the temperature of the distal end of second tube 616.
Temperature sensor 632 can be in electrical communication with controller 608 so as to provide a signal indicative of the temperature of the distal end of second tube 616 to the controller to provide a feedback signal for controlling the application of power to first tube 614, second tube 616, or both, as described in greater detail below.
Turning now to FIG. 4, yet another embodiment of CAG 602, CAG 640, is illustrated. CAG 640 is similar in many respects to CAG 612, except that CAG
is formed as a monolithic, integral, unitary structure formed as a single piece. A
first, proximal, upstream portion 642 receives pressurized fluid from source 604, as described above. An optional flow constrictor 644 is formed distally downstream of portion 642, and creates a drop in fluid pressure. A second, distal portion 646 is formed downstream of constrictor 644, and includes a distal exit port 648 from which vaporized fluid exits CAG 640. Thus, zone Z1 includes portion 642, zone includes portion 646, and zone Z3 includes constrictor 644. As in CAG 612, the heater elements for each of portions 642, 646 can be a portion of the walls of the CAG, attached to the walls of the GAG, or combinations thereof.
FIG. 5 schematically illustrates yet another embodiment, CAG 660. Similar to CAG 640, CAG 660 is preferably formed from a single piece of material and is electrically connected to controller 608 to define zones Z1, Z2, and Z3, as described above. Different from CAGs 612, 640, CAG 660 has a constant internal flow cross-sectional area in zones Zl and Z2, and an optional constrictor 662 is mounted or otherwise provided in zone Z3 to cause a drop in fluid pressure. Preferably, constrictor 662 is a porous plug formed of a material non-reactive to the fluid intended to flow through CAG 660, and includes pores therein which allow the fluid to flow through the plug and the CAG. Constrictor 660 is designed to provide a drop in fluid pressure between zones Z1 and Z2 at a predetermined fluid pressure and viscosity, in a manner well appreciated by one of ordinary skill in the art.
The function of controller 608 with CAG 612, 640, or 660 will now be described with reference to FIG. 6. Throughout this description, several variables will be discussed, as follows:
V(Z1).................voltage across zone Z1 V(Z2). ................voltage across zone P(Z1).. ...............electrical power used in zone Z1 P(Z2).. ...............electrical power used in zone Z2 T(Z1).................average temperature of CAG in zone Zl T(Z2).................average temperature of CAG in zone Z2 T(Z3).................average temperature of CAG in zone Z3 T(Z2') ................temperature of CAG at distal end of zone Z2 r(Zl)... ...............electrical resistance of portion of CAG in zone Zl r(Z2)... ...............electrical resistance of portion of CAG in zone Z2 M......................mass flow rate of fluid M(Z1)...............mass flow rate of fluid flowing through zone Z1 M(Z2)...............mass flow rate of fluid flowing through zone Z2 pr(Z1)...............fluid pressure drop across zone Z1 pr(Z2)...............fluid pressure drop across zone Z2 pr(Z3)...............fluid pressure drop across zone Z3 r~.......................fluid viscosity From the foregoing description, because there is no loss of fluid in the CAG
between zones Zl and Z2, the mass flow rates through these zones are identical, or M(Zl) = M(Z2) = M
As well appreciated by one of ordinary skill in the art, the electrical power (P) of an electrical component, its resistivity (r), the current (i) flowing through the element, and the electrical potential or voltage (V) across the element are interrelated, according to well-known relationships:
V=it P=i2r P=iV
P=VZIr Additionally, because of the design of the CAGs of the present invention, several other relationships can be used to measure and control electrical and physical characteristics of the CAG and the fluid flowing therethrough. It has been found by the inventors herein that the power consumed by the portion of the CAG in zone to maintain that portion of the CAG at a known temperature (the boiling point for the liquid being aerosolized, for example) is a function of the mass flow rate through the CAG:
P(Z2) = F(M) The exact functional relationship between power and mass flow rate can be readily empirically determined, as will be readily apparent to one of ordinary skill in the art.
Once this functional relationship is determined, it is used to form the instruction set in memory 610, or to design the logic of controller 608, as described below.
The materials from which the CAGs are formed, along with the heater elements themselves, are selected so that the average temperatures of zones Z1 and Z2 are functions of the resistance of the portions of the CAGs which are in these zones:
T(Z1) = F(r(Z1)) and T(Z2) = F(r(Z2)) Many materials, e.g., copper, stainless steel, and platinum, exhibit this relationship between temperature and resistance, and the function is linear over a wide range of temperatures. Thus, the material out of which the CAGs are formed, or at least the heater elements, is preferably selected to have a temperature-resistance function which is well l~nown, and preferably linear, over the range of temperatures in which system 600 will be used and the fluid will be aerosolized at least in the case where the resistance of the heater element is used to measure the temperature of the tube.
The CAG is preferably designed so that when controller 608 attempts to maintain the power consumed by the portion of the CAG in zone Z2 at its target level, P (target), the temperature of zone Z1 will be at a level, which is preferably at or slightly above the highest ambient temperature at which it is anticipated that system 600 would be used.
Additionally, the fluid to be aerosolized is preferably delivered to zone Zl by applying a constant pressure P. The fluid pressure drops across zones Z1 and Z2 are preferably close to zero:
pr(Z1) ~ pr(Z2) ~ 0 in which case:
P ~ pr(Z3) Furthermore, the pressure drop across zone Z3 is related to the mass flow rate of the fluid flowing through the CAG and the viscosity, eta, of the fluid in zone Z3, according to the relationship:
pr(Z3) =1~*M/eta where 1~ is a constant dependent upon the geometry of the channel in zone (Z3) and eta is the viscosity of the fluid in this zone, which viscosity is a function of the temperature of the fluid, that is:
eta = F(T(Z3)) Therefore:
P ~- 1~*M/eta or M ~ P*eta/k Thus, the mass flow rate of fluid through the CAG is determined by the applied pressure and the viscosity of the fluid in zone Z3. This latter quantity is, in turn, controlled by the temperature in zone Z3. It is for this reason that the flow constrictor is preferably provided, i.e., so that the mass flow rate can be more accurately controlled by adjusting the temperature in zone Z3.
These several functional interrelationships having been established, an exemplary control scheme for controller 608 will now be described with reference to FIG. 6. At the initiation of a cycle of generating a predetermined amount or bolus of aerosolized liquid, valve 606 is opened, allowing liquid at a known and preferably constant pressure to enter the CAG. At step 700, controller 608 applies and controls voltages across Z1 and Z2 to raise the temperature of the fluid therein. At step 702, the controller measures resistance r(Z2), to measure T(Z2). Alternatively, or as a redundant measurement, the controller measures T(Z2') at step 704 at the exit of zone Z2 with the thermocouple or thermistor. At step 706, the controller then compares the measured value of T(Z2), and adjusts V(Z2), and therefore P(Z2), to achieve a measured, target r(Z2), and therefore a target T(Z2). As will be readily appreciated by one of ordinary skill in the art, the temperature achieved can be within a predetermined range and still satisfy this condition, i.e., a certain, predetermined error is acceptable.
The controller then measures P(Z2) at step 708 which was needed to maintain T(Z2) at (or acceptably near) the target value, which gives a measure of the mass flow rate M of fluid flowing through the CAG, as discussed above. At step 710, the controller evaluates if the power measured to maintain the proper temperature, P(Z2), is greater than the power necessary, P(target), from the empirical relationship between power and mass flow rate. If so, the controller decreases the voltage, and therefore the power, applied to zone Z1. This is because when the mass flow rate is higher than desired, the fluid flowing through the CAG
will cool the zone Z2, requiring additional power to heat zone Z2 to the target temperature. A decrease in the voltage applied across zone Z1 lowers the temperature of the fluid therein, and therefore raises the viscosity, and therefore lowers the mass flow rate through zone Z2. This has the effect of malting zone Zl a flow controller for the CAG, and making zone Z2 a flow monitor for the CAG.
Similarly, at step 712 if the power measured across zone Z2 to achieve the target temperature T(Z2) is less than the target power, the controller increases the voltage across (and therefore the power used by) zone Z1 to increase the temperature of the fluid flowing through zone Zl, and thereby raises the mass flow rate.
At step 714, the controller sums or integrates mass flow rate over time to determine the total mass (m) delivered during the cycle. At step 716, the total mass m delivered is compared with a predetermined desired value of m. If the total mass actually delivered is less than the amount desired to be delivered, then the controller returns to step 700. If the total mass delivered is equal to or greater than the total mass desired, the flow of fluid from the source 604 is terminated by valve 606, and the voltages) across zones Z1 and Z2 are set to zero.
FIG. 7 schematically illustrates a control scheme for controller 608 which assists in determining if a fault condition exists in the CAG. The control scheme illustrated in FIG. 7 can be integrated into the control scheme illustrated in FIG. 6 and described with reference thereto, or can precede or follow the control scheme of FIG. 6. In step 730, the power consumed in zone Z2 is measured, which is a .
measure of the mass flow rate through zone Z2. The temperature of zone Z2 is then measured in step 732, either by measuring the resistance of the heater element in zone Z2, or by measuring the temperature T(Z2') at the thermocouple as at step 734.
At step 736, the controller determines whether the power consumption measured at zone Z2 is less than P(target), and the controller increases the voltage across (and therefore the~power consumed by) zone Z1, to increase the mass flow rate M. However, this action may fail to increase P(Z2) to P(target). A power consumption measurement which is low for the temperature measured can be indicative of a blockage in the flow passage of the CAG, which would lower the mass flow rate and the power P(Z2) required to achieve the target T(Z2). In this event, an alarm could be sounded, and the apparatus shut down.
At step 738, the controller determines whether the power consumption measured at zone Z2 is greater than P(target), and the controller decreases the voltage across (and therefore the power consumed by) zone Z1, to decrease the mass flow rate M. However, this action may fail to decrease P(Z2) to P(target). A
power consumption measurement which is high for the temperature measured can be indicative of an overflow condition in the flow passages of the CAG, which would raise the mass flow rate and the power P(Z2) required to achieve the target T(Z2).
In this event, an alarm could be sounded, and the apparatus shut down.
According to the invention, a control algorithm can be used to maintain a downstream heater at a desired target resistance. Once steady state operation is achieved (e.g., in less than 100 msec), the algorithm can calculate the energy consmnption (power) in the downstream heater based on an arbitrary time scan (e.g., 32 msec average). The frequency at which the upstream heater is pulsed can be adjusted up or down as a function of whether the downstream heater is operating at a desired target power. If the power in the downstream heater is below the target level, the time between the upstream heater pulses can be decreased to thereby increase the temperature in the upstream heater zone.
Experiments in which energy consumption and mass delivery are compared as a function of feed pressure are shown in Figures 8 and 9 wherein Figure 8 shows power as a function of feed pressure of propylene glycol in the case where the upstream heater is turned off, the run time is 10 seconds and the downstream resistance target is 0.36 ohms. Figure 9 shows aerosol mass delivery under the same conditions as used in Figure 8. Thus, Figures 8 and 9 show typical one heating zone response to increasing feed pressure. As shown, the power usage and aerosol mass increase in a linear fashion with increasing pressure.
In two-zone experiments, the downstream heater target power level was 2.6 watts, the upstream heater was turned off, and the feed pressure was 20 psi.
The initial setting for the upstream heater was to supply power to the upstream heater once every 8 msec. Further, pressure was varied from 6 to 30 psi and the energy usage and mass deliveries were measured. Figure 10 shows power curves as a function of pressure for the downstream heater, the upstream heater and both heaters, the downstream heater target resistance being set at 0.36 ohms, the downstream heater target power being set at 2.6 watts and the fluid being propylene glycol.
Figure 11 shows the aerosol mass delivery for propylene glycol (PG) in a two-zone heater wherein the run time was 10 seconds, the downstream heater target resistance was 0.36 ohms, the upstream heater firing frequency was once every msec and the downstream heater target power was 2.6 watts. Results for one-zone heating was added to Figure 11 for comparison. As shown, the aerosol mass delivery for the two-zone heating arrangement remains relatively constant over the feed pressure range of 6 to 20 psi. Above 20 psi, the aerosol mass delivery tracl~s the one-zone data because the target power level was set for the 20 psi case and the upstream heater is unable to cool the PG to compensate for an increase in pressure above this target. Accordingly, heating the PG to reduce its viscosity and increase its flow rate can be used to compensate for pressure variations and/or temperature variations. Moreover, these experiments demonstrate that power consumption of the downstream heater can be used as a feedbacl~ signal to control the upstream heater power. In the case illustrated in Figure 1 l, a 32 msec power average was used for the downstream heater and the heating arrangement responded rapidly to achieve the desired targets.
While the invention has been described in detail with reference to preferred embodiments thereof, it will be apparent to one slcilled in the art that various changes can be made, and equivalents employed, without departing from the scope of the invention.
Claims (18)
1. An aerosol generator comprising:
a flow passage having an inlet and an outlet;
a first heater in heat transfer communication with a first zone of the flow passage; and a second heater in heat transfer commuiucation with a second zone of the flow passage, the second heater being downstream of the first heater.
a flow passage having an inlet and an outlet;
a first heater in heat transfer communication with a first zone of the flow passage; and a second heater in heat transfer commuiucation with a second zone of the flow passage, the second heater being downstream of the first heater.
2. A capillary aerosol generator according to Claim 1, further comprising a flow constriction in the flow passage between the first zone and the second zone.
3. A capillary aerosol generator according to Claim 1, further comprising a controller in electrical communication with the first heater and the second heater, the controller selectively supplying a voltage across the first heater and the second heater.
4. A capillary aerosol generator according to Claim 3, wherein the controller selectively measures the resistance of the heater in the first zone and/or the second zone.
5. A capillary aerosol generator according to Claim 3, wherein the controller selectively measures the voltage across the first zone and the second zone.
6. A capillary aerosol generator according to Claim 3, wherein the controller comprises a memory including an instruction set which instructs the controller when to measure resistance, when to measure voltage, and when to apply voltage to the first zone, the second zone, or both.
7. A capillary aerosol generator according to Claim 1, wherein the flow passage comprises a first tube including the inlet wherein the first heater is in heat transfer communication with the first tube and a second tube including the outlet wherein the second heater is in heat transfer communication with the second tube.
8. A capillary aerosol generator according to Claim 7, wherein the flow passage in the first tube has a first inner diameter and the flow passage in the second tube has a second inner diameter, the first imler diameter being greater than the second inner diameter.
9. A capillary aerosol generator according to Claim 7, wherein the second tube is partially mounted in the first tube.
10. A capillary aerosol generator according to Claim 2, wherein the flow passage is in a monolithic, single-piece element, and the flow constrictor is integrally formed in the flow passage.
11. A capillary aerosol generator according to Claim 2, wherein the flow constrictor comprises a porous plug positioned in the flow passage.
12. A capillary aerosol generator according to Claim 1, further comprising a temperature sensor in heat transfer communication with the flow passage in the second zone.
13. A system useful for generating an aerosol, comprising:
a capillary aerosol generator according to Claim 1;
a source of pressurized fluid; and a valve between the source of pressurized fluid and the capillary aerosol generator.
a capillary aerosol generator according to Claim 1;
a source of pressurized fluid; and a valve between the source of pressurized fluid and the capillary aerosol generator.
14. A system according to Claim 13, wherein the valve is an automatically controllable valve, and further comprising a controller in electrical communication with the first heater, the second heater, and the valve, the controller selectively supplying a voltage across the first heater and the second heater, and the controller operative to selectively open and close the valve.
15. A process of forming an aerosol from a liquid, comprising the steps of:
supplying pressurized liquid to an upstream end of a flow passage of an aerosol generator including a first heater positioned in heat transfer communication with a first zone of the flow passage and a second heater positioned in heat transfer corntnunication with a second zone of the flow passage, the second zone being downstream of the first zone;
measuring a parameter indicative of the mass flow rate of the fluid flowing through the flow passage in the second zone;
changing the temperature in the first zone based on the measurement of the mass flow rate of the fluid through the second zone; and heating the liquid in the second zone such that the liquid is volatilized and sprayed from a downstream end of the flow passage in the form of an aerosol.
supplying pressurized liquid to an upstream end of a flow passage of an aerosol generator including a first heater positioned in heat transfer communication with a first zone of the flow passage and a second heater positioned in heat transfer corntnunication with a second zone of the flow passage, the second zone being downstream of the first zone;
measuring a parameter indicative of the mass flow rate of the fluid flowing through the flow passage in the second zone;
changing the temperature in the first zone based on the measurement of the mass flow rate of the fluid through the second zone; and heating the liquid in the second zone such that the liquid is volatilized and sprayed from a downstream end of the flow passage in the form of an aerosol.
16. A process forming an aerosol according to Claim 15, wherein the liquid passes through a flow constrictor in the flow passage between the first zone and the second zone.
17. A process of forming an aerosol according to Claim 15, further comprising the steps of:
measuring the temperature in the second zone; and adjusting a voltage across the second heater based on the temperature measured in the second zone.
measuring the temperature in the second zone; and adjusting a voltage across the second heater based on the temperature measured in the second zone.
18. A process of forming an aerosol according to Claim 15, wherein the step of changing the temperature in the first zone comprises the steps of:
comparing the power consumed in maintaining the temperature of the second heater at a predetermined temperature (P(Z2)) to a target power level (P (Target));
decreasing the power applied to the first heater if (P(Z2)) >
(P(Target)); and increasing the power applied to the first heater if (P(Z2)) <
(P(Target)).
comparing the power consumed in maintaining the temperature of the second heater at a predetermined temperature (P(Z2)) to a target power level (P (Target));
decreasing the power applied to the first heater if (P(Z2)) >
(P(Target)); and increasing the power applied to the first heater if (P(Z2)) <
(P(Target)).
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US09/742,322 US6501052B2 (en) | 2000-12-22 | 2000-12-22 | Aerosol generator having multiple heating zones and methods of use thereof |
| US09/742,322 | 2000-12-22 | ||
| PCT/US2001/045257 WO2002051468A2 (en) | 2000-12-22 | 2001-12-03 | Aerosol generator having multiple heating zones and methods of use thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CA2432081A1 true CA2432081A1 (en) | 2002-07-04 |
| CA2432081C CA2432081C (en) | 2013-06-04 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA2432081A Expired - Lifetime CA2432081C (en) | 2000-12-22 | 2001-12-03 | Aerosol generator having multiple heating zones and methods of use thereof |
Country Status (7)
| Country | Link |
|---|---|
| US (2) | US6501052B2 (en) |
| EP (1) | EP1346606B1 (en) |
| JP (2) | JP4339590B2 (en) |
| CN (1) | CN100342753C (en) |
| AU (1) | AU2002233945A1 (en) |
| CA (1) | CA2432081C (en) |
| WO (1) | WO2002051468A2 (en) |
Families Citing this family (208)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6234167B1 (en) * | 1998-10-14 | 2001-05-22 | Chrysalis Technologies, Incorporated | Aerosol generator and methods of making and using an aerosol generator |
| US6701921B2 (en) | 2000-12-22 | 2004-03-09 | Chrysalis Technologies Incorporated | Aerosol generator having heater in multilayered composite and method of use thereof |
| US7585493B2 (en) * | 2001-05-24 | 2009-09-08 | Alexza Pharmaceuticals, Inc. | Thin-film drug delivery article and method of use |
| US7645442B2 (en) | 2001-05-24 | 2010-01-12 | Alexza Pharmaceuticals, Inc. | Rapid-heating drug delivery article and method of use |
| US7766013B2 (en) | 2001-06-05 | 2010-08-03 | Alexza Pharmaceuticals, Inc. | Aerosol generating method and device |
| US7458374B2 (en) | 2002-05-13 | 2008-12-02 | Alexza Pharmaceuticals, Inc. | Method and apparatus for vaporizing a compound |
| TWI239251B (en) * | 2001-07-31 | 2005-09-11 | Chrysalis Tech Inc | Method and apparatus for generating a volatilized liquid |
| US6568390B2 (en) | 2001-09-21 | 2003-05-27 | Chrysalis Technologies Incorporated | Dual capillary fluid vaporizing device |
| GB0123851D0 (en) | 2001-10-04 | 2001-11-28 | Pankhurst Design & Development | Dispersing fragrances |
| ES2357566T3 (en) | 2002-09-06 | 2011-04-27 | Philip Morris Usa Inc. | AEROSOL GENERATING DEVICES AND METHODS FOR GENERATING AEROSOLS WITH CONTROLLED PARTICLE SIZES. |
| EP1549440B1 (en) * | 2002-09-06 | 2012-12-12 | Philip Morris USA Inc. | Aerosol generating device and method of use thereof |
| US6772757B2 (en) | 2002-10-25 | 2004-08-10 | Chrysalis Technologies Incorporated | Concentric controlled temperature profile fluid vaporizing device |
| US7913688B2 (en) | 2002-11-27 | 2011-03-29 | Alexza Pharmaceuticals, Inc. | Inhalation device for producing a drug aerosol |
| EP1596824A4 (en) * | 2003-02-04 | 2011-11-23 | Chrysalis Tech Inc | Aerosol formulations and aerosol delivery of buspirone, buprenorphine, triazolam, cyclobenzaprine and zolpidem |
| US7726303B2 (en) * | 2003-02-25 | 2010-06-01 | Hewlett-Packard Development Company, L.P. | Controlled medicament ejection |
| CN100381083C (en) | 2003-04-29 | 2008-04-16 | 韩力 | Electronic nonflammable spraying cigarette |
| WO2004112799A1 (en) * | 2003-06-13 | 2004-12-29 | Chrysalis Technologies Incorporated | Methods and apparatus for producing nanoscale particles |
| US20040265519A1 (en) * | 2003-06-27 | 2004-12-30 | Pellizzari Roberto O. | Fabrication of fluid delivery components |
| US7367334B2 (en) * | 2003-08-27 | 2008-05-06 | Philip Morris Usa Inc. | Fluid vaporizing device having controlled temperature profile heater/capillary tube |
| WO2005037949A2 (en) * | 2003-10-07 | 2005-04-28 | Chrysalis Technologies Incorporated | Aerosol formulations of butalbital, lorazepam, ipratropium, baclofen, morphine and scopolamine |
| CN2719043Y (en) | 2004-04-14 | 2005-08-24 | 韩力 | Atomized electronic cigarette |
| HUE026152T2 (en) * | 2004-04-23 | 2016-05-30 | Philip Morris Products Sa | Aerosol generators and methods for producing aerosols |
| US7540286B2 (en) | 2004-06-03 | 2009-06-02 | Alexza Pharmaceuticals, Inc. | Multiple dose condensation aerosol devices and methods of forming condensation aerosols |
| US7167776B2 (en) * | 2004-09-02 | 2007-01-23 | Philip Morris Usa Inc. | Method and system for controlling a vapor generator |
| US20060102175A1 (en) * | 2004-11-18 | 2006-05-18 | Nelson Stephen G | Inhaler |
| DE102004061883A1 (en) * | 2004-12-22 | 2006-07-06 | Vishay Electronic Gmbh | Heating device for inhalation device, inhaler and heating method |
| AU2006338285B8 (en) * | 2005-02-09 | 2012-11-08 | S3I, Llc | Method and system for detecting, classifying and identifying particles |
| US10244793B2 (en) | 2005-07-19 | 2019-04-02 | Juul Labs, Inc. | Devices for vaporization of a substance |
| US7186958B1 (en) * | 2005-09-01 | 2007-03-06 | Zhao Wei, Llc | Inhaler |
| FR2891435B1 (en) * | 2005-09-23 | 2007-11-09 | Bull Sa Sa | HOLDING SYSTEM IN POSITION OF A THREE-PART ASSEMBLY PROVIDING A PREDETERMINAL COMPRESSION EFFORT ON THE INTERMEDIATE PART |
| EP1957862B1 (en) * | 2005-12-01 | 2017-01-04 | Vapore, LLC | Apparatus and method for the generation of pressurized vapor from a liquid |
| US8596268B2 (en) * | 2005-12-22 | 2013-12-03 | Donovan B. Yeates | Method of operating a compact, low flow resistance aerosol generator |
| US7494344B2 (en) | 2005-12-29 | 2009-02-24 | Molex Incorporated | Heating element connector assembly with press-fit terminals |
| PL2047880T3 (en) * | 2006-08-01 | 2018-02-28 | Japan Tobacco Inc. | Aerosol suction device, and its sucking method |
| TR201808388T4 (en) * | 2006-10-02 | 2018-07-23 | Philip Morris Products Sa | Continuous high pressure transmission system. |
| US7726320B2 (en) | 2006-10-18 | 2010-06-01 | R. J. Reynolds Tobacco Company | Tobacco-containing smoking article |
| US8020726B1 (en) * | 2006-10-18 | 2011-09-20 | Sandia Corporation | Powder dispersion system |
| US7513781B2 (en) | 2006-12-27 | 2009-04-07 | Molex Incorporated | Heating element connector assembly with insert molded strips |
| ES2594867T3 (en) | 2007-03-09 | 2016-12-23 | Alexza Pharmaceuticals, Inc. | Heating unit for use in a drug delivery device |
| EP3858411A1 (en) | 2007-08-24 | 2021-08-04 | ResMed Pty Ltd | Mask vent |
| US8442390B2 (en) | 2007-08-29 | 2013-05-14 | Philip Morris Usa Inc. | Pulsed aerosol generation |
| EP2211955B1 (en) * | 2007-10-02 | 2017-04-12 | Philip Morris Products S.A. | Dispensing method and system of a capillary aerosol generator |
| MX2010003438A (en) * | 2007-10-02 | 2010-04-21 | Philip Morris Prod | Biomarkers and methods for determining sensitivity to vascular endothelial growth factor receptor-2 modulators. |
| US8052127B2 (en) | 2007-10-19 | 2011-11-08 | Philip Morris Usa Inc. | Respiratory humidification system |
| US9179691B2 (en) | 2007-12-14 | 2015-11-10 | Aerodesigns, Inc. | Delivering aerosolizable food products |
| US8320751B2 (en) | 2007-12-20 | 2012-11-27 | S.C. Johnson & Son, Inc. | Volatile material diffuser and method of preventing undesirable mixing of volatile materials |
| US8201752B2 (en) * | 2008-03-10 | 2012-06-19 | Vapore, Inc. | Low energy vaporization of liquids: apparatus and methods |
| EP2110034A1 (en) | 2008-04-17 | 2009-10-21 | Philip Morris Products S.A. | An electrically heated smoking system |
| AT507187B1 (en) | 2008-10-23 | 2010-03-15 | Helmut Dr Buchberger | INHALER |
| EP3132806B1 (en) | 2009-10-13 | 2022-03-16 | Philip Morris Products S.A. | Aerosol generator |
| US8637794B2 (en) | 2009-10-21 | 2014-01-28 | Lam Research Corporation | Heating plate with planar heating zones for semiconductor processing |
| AU2010320708B2 (en) | 2009-11-18 | 2014-10-23 | Reckitt Benckiser Llc | Lavatory treatment device and method |
| EP2501492B1 (en) | 2009-11-18 | 2019-12-25 | Reckitt Benckiser LLC | Ultrasonic surface treatment device and method |
| EP2327318A1 (en) | 2009-11-27 | 2011-06-01 | Philip Morris Products S.A. | An electrically heated smoking system with internal or external heater |
| JP6066728B2 (en) * | 2009-12-15 | 2017-01-25 | ラム リサーチ コーポレーションＬａｍ Ｒｅｓｅａｒｃｈ Ｃｏｒｐｏｒａｔｉｏｎ | Method for adjusting substrate temperature and plasma etching system for improving CD uniformity |
| USD639923S1 (en) | 2010-04-15 | 2011-06-14 | S.C. Johnson & Son, Inc. | Dispensing device |
| US9861772B2 (en) | 2010-05-15 | 2018-01-09 | Rai Strategic Holdings, Inc. | Personal vaporizing inhaler cartridge |
| US10159278B2 (en) | 2010-05-15 | 2018-12-25 | Rai Strategic Holdings, Inc. | Assembly directed airflow |
| US10136672B2 (en) | 2010-05-15 | 2018-11-27 | Rai Strategic Holdings, Inc. | Solderless directly written heating elements |
| US9743691B2 (en) | 2010-05-15 | 2017-08-29 | Rai Strategic Holdings, Inc. | Vaporizer configuration, control, and reporting |
| US9095175B2 (en) | 2010-05-15 | 2015-08-04 | R. J. Reynolds Tobacco Company | Data logging personal vaporizing inhaler |
| US9999250B2 (en) | 2010-05-15 | 2018-06-19 | Rai Strategic Holdings, Inc. | Vaporizer related systems, methods, and apparatus |
| US11344683B2 (en) | 2010-05-15 | 2022-05-31 | Rai Strategic Holdings, Inc. | Vaporizer related systems, methods, and apparatus |
| US9259035B2 (en) | 2010-05-15 | 2016-02-16 | R. J. Reynolds Tobacco Company | Solderless personal vaporizing inhaler |
| US8757147B2 (en) | 2010-05-15 | 2014-06-24 | Minusa Holdings Llc | Personal vaporizing inhaler with internal light source |
| EP3508083B1 (en) | 2010-08-24 | 2021-07-14 | JT International S.A. | Inhalation device including substance usage controls |
| WO2012033943A2 (en) * | 2010-09-08 | 2012-03-15 | Molecular Imprints, Inc. | Vapor delivery system for use in imprint lithography |
| US8791392B2 (en) | 2010-10-22 | 2014-07-29 | Lam Research Corporation | Methods of fault detection for multiplexed heater array |
| US8546732B2 (en) | 2010-11-10 | 2013-10-01 | Lam Research Corporation | Heating plate with planar heater zones for semiconductor processing |
| US9301547B2 (en) * | 2010-11-19 | 2016-04-05 | Huizhou Kimree Technology Co., Ltd. Shenzhen Branch | Electronic cigarette, electronic cigarette smoke capsule and atomization device thereof |
| EP2468117A1 (en) | 2010-12-24 | 2012-06-27 | Philip Morris Products S.A. | An aerosol generating system having means for determining depletion of a liquid substrate |
| EP2468116A1 (en) * | 2010-12-24 | 2012-06-27 | Philip Morris Products S.A. | An aerosol generating system having means for handling consumption of a liquid substrate |
| EP2468118A1 (en) | 2010-12-24 | 2012-06-27 | Philip Morris Products S.A. | An aerosol generating system with means for disabling a consumable |
| CN114522318A (en) | 2011-01-24 | 2022-05-24 | 瑞思迈私人有限公司 | Humidifier |
| US9149586B2 (en) * | 2011-02-07 | 2015-10-06 | Seibo Ping-Cheng SHEN | Herbal vaporization apparatus and method |
| AT510837B1 (en) * | 2011-07-27 | 2012-07-15 | Helmut Dr Buchberger | INHALATORKOMPONENTE |
| HUE026804T2 (en) | 2011-02-11 | 2016-07-28 | Batmark Ltd | Inhaler component |
| US8528569B1 (en) | 2011-06-28 | 2013-09-10 | Kyle D. Newton | Electronic cigarette with liquid reservoir |
| US9078473B2 (en) | 2011-08-09 | 2015-07-14 | R.J. Reynolds Tobacco Company | Smoking articles and use thereof for yielding inhalation materials |
| US9307578B2 (en) | 2011-08-17 | 2016-04-05 | Lam Research Corporation | System and method for monitoring temperatures of and controlling multiplexed heater array |
| EP2753200B1 (en) | 2011-09-06 | 2017-12-27 | British American Tobacco (Investments) Limited | Heating smokeable material |
| KR101752639B1 (en) | 2011-09-06 | 2017-06-30 | 브리티시 아메리칸 토바코 (인베스트먼츠) 리미티드 | Heating smokable material |
| MY164560A (en) | 2011-09-06 | 2018-01-15 | British American Tobacco Investments Ltd | Heating Smokeable Material |
| US10388493B2 (en) | 2011-09-16 | 2019-08-20 | Lam Research Corporation | Component of a substrate support assembly producing localized magnetic fields |
| AT511344B1 (en) * | 2011-10-21 | 2012-11-15 | Helmut Dr Buchberger | INHALATORKOMPONENTE |
| SG11201403677XA (en) * | 2011-12-30 | 2014-07-30 | Philip Morris Products Sa | Aerosol generating device with air flow detection |
| EP2609820A1 (en) * | 2011-12-30 | 2013-07-03 | Philip Morris Products S.A. | Detection of aerosol-forming substrate in an aerosol generating device |
| US9326547B2 (en) | 2012-01-31 | 2016-05-03 | Altria Client Services Llc | Electronic vaping article |
| EP2817051B1 (en) | 2012-02-22 | 2017-07-26 | Altria Client Services LLC | Electronic smoking article |
| US9324589B2 (en) | 2012-02-28 | 2016-04-26 | Lam Research Corporation | Multiplexed heater array using AC drive for semiconductor processing |
| US8809747B2 (en) * | 2012-04-13 | 2014-08-19 | Lam Research Corporation | Current peak spreading schemes for multiplexed heated array |
| GB201207039D0 (en) | 2012-04-23 | 2012-06-06 | British American Tobacco Co | Heating smokeable material |
| GB2504076A (en) | 2012-07-16 | 2014-01-22 | Nicoventures Holdings Ltd | Electronic smoking device |
| US9713687B2 (en) | 2012-08-21 | 2017-07-25 | Philip Morris Usa Inc. | Ventilator aerosol delivery system with transition adapter for introducing carrier gas |
| AU2012388598B2 (en) * | 2012-08-31 | 2016-11-24 | Huizhou Kimree Technology Co., Ltd., Shenzhen Branch | Electronic cigarette |
| US8881737B2 (en) | 2012-09-04 | 2014-11-11 | R.J. Reynolds Tobacco Company | Electronic smoking article comprising one or more microheaters |
| US8910639B2 (en) | 2012-09-05 | 2014-12-16 | R. J. Reynolds Tobacco Company | Single-use connector and cartridge for a smoking article and related method |
| PL2895930T3 (en) | 2012-09-11 | 2017-04-28 | Philip Morris Products S.A. | Device and method for controlling an electrical heater to control temperature |
| US9854841B2 (en) | 2012-10-08 | 2018-01-02 | Rai Strategic Holdings, Inc. | Electronic smoking article and associated method |
| US10049948B2 (en) | 2012-11-30 | 2018-08-14 | Lam Research Corporation | Power switching system for ESC with array of thermal control elements |
| US9210738B2 (en) | 2012-12-07 | 2015-12-08 | R.J. Reynolds Tobacco Company | Apparatus and method for winding a substantially continuous heating element about a substantially continuous wick |
| PL2938377T3 (en) | 2012-12-27 | 2020-08-10 | BREIWA, III, George, R. | Tubular volatizing device |
| LT2882308T (en) | 2012-12-28 | 2016-11-10 | Philip Morris Products S.A. | Heating assembly for an aerosol generating system |
| US9423152B2 (en) | 2013-03-15 | 2016-08-23 | R. J. Reynolds Tobacco Company | Heating control arrangement for an electronic smoking article and associated system and method |
| US9220302B2 (en) | 2013-03-15 | 2015-12-29 | R.J. Reynolds Tobacco Company | Cartridge for an aerosol delivery device and method for assembling a cartridge for a smoking article |
| US20140261488A1 (en) * | 2013-03-15 | 2014-09-18 | Altria Client Services Inc. | Electronic smoking article |
| US9609893B2 (en) | 2013-03-15 | 2017-04-04 | Rai Strategic Holdings, Inc. | Cartridge and control body of an aerosol delivery device including anti-rotation mechanism and related method |
| US9491974B2 (en) | 2013-03-15 | 2016-11-15 | Rai Strategic Holdings, Inc. | Heating elements formed from a sheet of a material and inputs and methods for the production of atomizers |
| GB2513637A (en) | 2013-05-02 | 2014-11-05 | Nicoventures Holdings Ltd | Electronic cigarette |
| GB2513638A (en) | 2013-05-02 | 2014-11-05 | Nicoventures Holdings Ltd | Electronic cigarette |
| GB2513639A (en) | 2013-05-02 | 2014-11-05 | Nicoventures Holdings Ltd | Electronic cigarette |
| GB2514893B (en) | 2013-06-04 | 2017-12-06 | Nicoventures Holdings Ltd | Container |
| EP3011405B1 (en) * | 2013-06-19 | 2018-03-28 | Fontem Holdings 4 B.V. | Device for sensing mass airflow |
| FI125544B (en) * | 2013-08-14 | 2015-11-30 | Pixan Oy | Apparatus and method for controlling an electric vaporizer |
| US9820509B2 (en) | 2013-10-10 | 2017-11-21 | Kyle D. Newton | Electronic cigarette with encoded cartridge |
| UA125080C2 (en) | 2013-10-29 | 2022-01-05 | Брітіш Амерікан Тобакко (Інвестментс) Лімітед | Device for heating smoking material |
| US10292424B2 (en) | 2013-10-31 | 2019-05-21 | Rai Strategic Holdings, Inc. | Aerosol delivery device including a pressure-based aerosol delivery mechanism |
| US10039321B2 (en) | 2013-11-12 | 2018-08-07 | Vmr Products Llc | Vaporizer |
| US10980273B2 (en) | 2013-11-12 | 2021-04-20 | VMR Products, LLC | Vaporizer, charger and methods of use |
| WO2015073975A1 (en) | 2013-11-15 | 2015-05-21 | VMR Products, LLC | Vaporizer with cover sleeve |
| ES2720264T3 (en) * | 2013-12-11 | 2019-07-19 | Jt Int Sa | Heating system and procedure for heating an inhaler device |
| US20160366947A1 (en) | 2013-12-23 | 2016-12-22 | James Monsees | Vaporizer apparatus |
| US10076139B2 (en) | 2013-12-23 | 2018-09-18 | Juul Labs, Inc. | Vaporizer apparatus |
| USD842536S1 (en) | 2016-07-28 | 2019-03-05 | Juul Labs, Inc. | Vaporizer cartridge |
| USD825102S1 (en) | 2016-07-28 | 2018-08-07 | Juul Labs, Inc. | Vaporizer device with cartridge |
| KR102256886B1 (en) | 2013-12-23 | 2021-05-31 | 쥴 랩스, 인크. | Vaporization device systems and methods |
| US10058129B2 (en) | 2013-12-23 | 2018-08-28 | Juul Labs, Inc. | Vaporization device systems and methods |
| US10159282B2 (en) | 2013-12-23 | 2018-12-25 | Juul Labs, Inc. | Cartridge for use with a vaporizer device |
| US9451791B2 (en) | 2014-02-05 | 2016-09-27 | Rai Strategic Holdings, Inc. | Aerosol delivery device with an illuminated outer surface and related method |
| US10709173B2 (en) | 2014-02-06 | 2020-07-14 | Juul Labs, Inc. | Vaporizer apparatus |
| TWI684414B (en) | 2014-02-06 | 2020-02-11 | 美商尤爾實驗室有限公司 | Vaporization device systems and methods |
| US9833019B2 (en) | 2014-02-13 | 2017-12-05 | Rai Strategic Holdings, Inc. | Method for assembling a cartridge for a smoking article |
| FR3017954B1 (en) * | 2014-02-21 | 2016-12-02 | Smokio | ELECTRONIC CIGARETTE |
| US9839238B2 (en) | 2014-02-28 | 2017-12-12 | Rai Strategic Holdings, Inc. | Control body for an electronic smoking article |
| USD763502S1 (en) | 2014-03-04 | 2016-08-09 | Vmr Products Llc | Cartomizer for a vaporizer |
| USD788697S1 (en) | 2014-03-04 | 2017-06-06 | VMR Products, LLC | Battery portion for a vaporizer |
| USD749505S1 (en) | 2014-03-07 | 2016-02-16 | VMR Products, LLC | Charger for a vaporizer |
| USD752280S1 (en) | 2014-03-07 | 2016-03-22 | VMR Products, LLC | Cartomizer for a vaporizer |
| USD752278S1 (en) | 2014-03-07 | 2016-03-22 | VMR Products, LLC | Battery portion of a vaporizer |
| US9597466B2 (en) | 2014-03-12 | 2017-03-21 | R. J. Reynolds Tobacco Company | Aerosol delivery system and related method, apparatus, and computer program product for providing control information to an aerosol delivery device via a cartridge |
| USD804090S1 (en) | 2014-04-08 | 2017-11-28 | VMR Products, LLC | Vaporizer with indicators |
| GB201407426D0 (en) | 2014-04-28 | 2014-06-11 | Batmark Ltd | Aerosol forming component |
| USD750320S1 (en) | 2014-08-05 | 2016-02-23 | VMR Products, LLC | Vaporizer |
| WO2015192084A1 (en) * | 2014-06-14 | 2015-12-17 | Evolv, Llc | Electronic vaporizer having temperature sensing and limit |
| GB2528673B (en) | 2014-07-25 | 2020-07-01 | Nicoventures Holdings Ltd | Aerosol provision system |
| CA160775S (en) | 2014-08-11 | 2015-09-29 | Ploom Inc | Electronic vaporization device with cartridge |
| GB2529629B (en) | 2014-08-26 | 2021-05-12 | Nicoventures Trading Ltd | Electronic aerosol provision system |
| ES2811086T3 (en) * | 2014-09-16 | 2021-03-10 | Medituner Ab | Computer controlled dosing system |
| KR102627987B1 (en) * | 2014-12-05 | 2024-01-22 | 쥴 랩스, 인크. | Calibrated dose control |
| GB2533135B (en) | 2014-12-11 | 2020-11-11 | Nicoventures Holdings Ltd | Aerosol provision systems |
| RU2681342C2 (en) * | 2015-01-22 | 2019-03-06 | Фонтем Холдингс 1 Б.В. | Electronic evaporating devices |
| HUE059022T2 (en) * | 2015-02-05 | 2022-10-28 | Giorgio Torchio | Capillary proximity heater with high energy saving equipped upstream of a microfiltration apparatus for the elimination of calcareuos particles present in fluids and downstream of a nozzle or closed circuit |
| US20210172650A1 (en) * | 2015-02-05 | 2021-06-10 | Giorgio TORCHIO | Capillary Proximity Heater |
| WO2016194076A1 (en) * | 2015-05-29 | 2016-12-08 | 日本たばこ産業株式会社 | Non-combustion flavor inhaler |
| EP3283149B1 (en) * | 2015-06-10 | 2023-08-02 | Evolv, LLC | Electronic vaporizer having reduced particle size |
| GB201511358D0 (en) | 2015-06-29 | 2015-08-12 | Nicoventures Holdings Ltd | Electronic aerosol provision systems |
| GB201511359D0 (en) | 2015-06-29 | 2015-08-12 | Nicoventures Holdings Ltd | Electronic vapour provision system |
| GB201511349D0 (en) | 2015-06-29 | 2015-08-12 | Nicoventures Holdings Ltd | Electronic aerosol provision systems |
| WO2017011698A1 (en) | 2015-07-14 | 2017-01-19 | Dynavap, LLC | Exothermal vaporizer |
| KR101840219B1 (en) | 2015-08-31 | 2018-03-20 | 삼성에스디아이 주식회사 | Low Temperature Curable Composition, Cured Film Prepared therefrom, and Electronic Device Incorporating the Cured Film |
| US20170055584A1 (en) | 2015-08-31 | 2017-03-02 | British American Tobacco (Investments) Limited | Article for use with apparatus for heating smokable material |
| US11924930B2 (en) | 2015-08-31 | 2024-03-05 | Nicoventures Trading Limited | Article for use with apparatus for heating smokable material |
| US10034494B2 (en) | 2015-09-15 | 2018-07-31 | Rai Strategic Holdings, Inc. | Reservoir for aerosol delivery devices |
| US10412996B2 (en) * | 2015-12-22 | 2019-09-17 | Altria Client Services Llc | Cartridge for pump-operated aerosol-generating system |
| US10398174B2 (en) * | 2015-12-22 | 2019-09-03 | Altria Client Services Llc | Aerosol-generating system with pump |
| MX2018007316A (en) * | 2015-12-22 | 2018-09-11 | Philip Morris Products Sa | An electrically operated aerosol-generating system with a liquid pump. |
| US10624392B2 (en) * | 2015-12-22 | 2020-04-21 | Altria Client Services Llc | Aerosol-generating system with motor |
| US11471619B2 (en) * | 2016-01-11 | 2022-10-18 | Arizona Board Of Regents On Behalf Of Arizona State University | Ereptiospiration device for medicinal waxes, solids, biopolymers, or highly viscous oils, and cannabinoids |
| MX2018009703A (en) | 2016-02-11 | 2019-07-08 | Juul Labs Inc | Securely attaching cartridges for vaporizer devices. |
| US10455863B2 (en) | 2016-03-03 | 2019-10-29 | Altria Client Services Llc | Cartridge for electronic vaping device |
| US10433580B2 (en) | 2016-03-03 | 2019-10-08 | Altria Client Services Llc | Methods to add menthol, botanic materials, and/or non-botanic materials to a cartridge, and/or an electronic vaping device including the cartridge |
| WO2017153827A1 (en) | 2016-03-07 | 2017-09-14 | Wallbrooke Investments Ltd. | Inductive heating apparatus and related method |
| US10368580B2 (en) | 2016-03-08 | 2019-08-06 | Altria Client Services Llc | Combined cartridge for electronic vaping device |
| US10405582B2 (en) | 2016-03-10 | 2019-09-10 | Pax Labs, Inc. | Vaporization device with lip sensing |
| US10368581B2 (en) | 2016-03-11 | 2019-08-06 | Altria Client Services Llc | Multiple dispersion generator e-vaping device |
| US10357060B2 (en) | 2016-03-11 | 2019-07-23 | Altria Client Services Llc | E-vaping device cartridge holder |
| US10905163B2 (en) | 2016-03-31 | 2021-02-02 | Altria Client Services Llc | Aerosol-generating system with pump |
| CA3013331A1 (en) * | 2016-03-31 | 2017-10-05 | Philip Morris Products S.A. | Aerosol-generating system with pump |
| CA3103090C (en) | 2016-04-27 | 2023-03-28 | Nicoventures Trading Limited | Electronic aerosol provision system and vaporizer therefor |
| US11425911B2 (en) | 2017-05-25 | 2022-08-30 | Markesbery Blue Pearl LLC | Method for disinfection of items and spaces |
| US9861102B2 (en) | 2016-05-26 | 2018-01-09 | Markesbery Blue Pearl LLC | Methods for disinfection |
| CA3027975A1 (en) | 2016-06-16 | 2017-12-21 | Juul Labs, Inc. | On-demand, portable convection vaporizer |
| USD849996S1 (en) | 2016-06-16 | 2019-05-28 | Pax Labs, Inc. | Vaporizer cartridge |
| USD851830S1 (en) | 2016-06-23 | 2019-06-18 | Pax Labs, Inc. | Combined vaporizer tamp and pick tool |
| USD836541S1 (en) | 2016-06-23 | 2018-12-25 | Pax Labs, Inc. | Charging device |
| FR3053883B1 (en) | 2016-07-12 | 2022-04-29 | Deuxventorio Sarl | METHOD FOR MANUFACTURING A REAMER |
| GB201612945D0 (en) | 2016-07-26 | 2016-09-07 | British American Tobacco Investments Ltd | Method of generating aerosol |
| EP3515219B1 (en) * | 2016-09-20 | 2022-11-16 | Nicoventures Trading Limited | A method of manufacturing an aerosol provision apparatus and an aerosol provision apparatus |
| CN110035788B (en) * | 2016-12-16 | 2021-12-21 | 菲利普莫里斯生产公司 | Aerosol-generating system with fluid sensor |
| USD887632S1 (en) | 2017-09-14 | 2020-06-16 | Pax Labs, Inc. | Vaporizer cartridge |
| US11140895B2 (en) | 2017-10-13 | 2021-10-12 | Wyndscent, Llc | Electronic vapor dispenser for hunting |
| CN111970937A (en) | 2018-02-27 | 2020-11-20 | 尤尔实验室有限公司 | Evaporator with controlled mass output |
| KR20210018894A (en) * | 2018-06-07 | 2021-02-18 | 필립모리스 프로덕츠 에스.에이. | Aerosol generating device |
| CN112638453A (en) * | 2018-06-26 | 2021-04-09 | 欧米伽生命科学公司 | Aerosol generating device |
| PL3826705T3 (en) | 2018-07-23 | 2023-01-16 | Juul Labs, Inc. | Airflow management for vaporizer device |
| US11413409B2 (en) * | 2018-09-12 | 2022-08-16 | Juul Labs, Inc. | Vaporizer including positive temperature coefficient of resistivity (PTCR) heating element |
| US11607506B2 (en) | 2019-02-22 | 2023-03-21 | Altria Client Services Llc | Electronic dispersion device |
| CN113840547A (en) * | 2019-05-06 | 2021-12-24 | 进立有限公司 | Flat heating element for miniature evaporator |
| KR102330310B1 (en) * | 2019-12-27 | 2021-11-24 | 주식회사 케이티앤지 | Aerosol generating device that emits visually different vapor depending on mode |
| JP1714442S (en) | 2020-10-30 | 2022-05-10 | Smoking aerosol generator | |
| JP1714440S (en) | 2020-10-30 | 2022-05-10 | Smoking aerosol generator | |
| JP1714441S (en) | 2020-10-30 | 2022-05-10 | Smoking aerosol generator | |
| JP1714443S (en) | 2020-10-30 | 2022-05-10 | Smoking aerosol generator | |
| USD990765S1 (en) | 2020-10-30 | 2023-06-27 | Nicoventures Trading Limited | Aerosol generator |
| JP1715888S (en) | 2020-10-30 | 2022-05-25 | Smoking aerosol generator | |
| US11789476B2 (en) | 2021-01-18 | 2023-10-17 | Altria Client Services Llc | Heat-not-burn (HNB) aerosol-generating devices including intra-draw heater control, and methods of controlling a heater |
| USD989384S1 (en) | 2021-04-30 | 2023-06-13 | Nicoventures Trading Limited | Aerosol generator |
| GB202207302D0 (en) * | 2022-05-18 | 2022-06-29 | Inspired Ventilation Ltd | Breathing system for substance inhalation |
Family Cites Families (204)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BE354094A (en) | 1928-09-11 | 1928-10-31 | Rene Vendegies | Improvements made to devices for vaporizing liquids, particularly those for medical inhalations. |
| FR667979A (en) | 1929-01-24 | 1929-10-25 | Heated liquid medical gasifier with pneumatically balanced level | |
| DE1036470C2 (en) | 1956-09-18 | 1959-01-29 | Bergbau Berufsgenossenschaft | Method and device for generating a common salt aerosol |
| US2896856A (en) | 1956-12-21 | 1959-07-28 | Licencia Talalmanyokat | Vaporizer for diesel engines |
| US3084698A (en) | 1960-04-01 | 1963-04-09 | Marvin M Smith | Instrument for cooling smoke |
| US3162324A (en) | 1961-11-22 | 1964-12-22 | Robertshaw Controls Co | Pneumatic dispenser |
| NL297349A (en) | 1962-08-31 | |||
| US3431393A (en) | 1965-09-07 | 1969-03-04 | Dainippon Jochugiku Kk | Apparatus for vaporizing chemicals and perfumes by heating |
| US3486663A (en) | 1967-11-16 | 1969-12-30 | Frederick Harold Humphrey | Elastomeric pump and check-valve |
| DE1813993C3 (en) | 1968-12-11 | 1974-01-24 | Paul Ritzau Pari-Werk Kg, 8135 Soecking | Device for atomizing and atomizing liquid or powdery substances |
| US3716416A (en) | 1971-05-20 | 1973-02-13 | Engelhard Min & Chem | Fuel metering device for fuel cell |
| US3750961A (en) | 1971-07-16 | 1973-08-07 | N Franz | Very high velocity fluid jet nozzles and methods of making same |
| BE788194A (en) | 1971-08-31 | 1973-02-28 | Thomae Gmbh Dr K | DEVICE FOR THE ADMINISTRATION OF MECHANICALLY DOSE QUANTITIES OF LIQUID OR SOLUTION MEDICINAL PRODUCTS |
| US3859398A (en) | 1972-10-05 | 1975-01-07 | Hudson Oxygen Therapy Sales Co | Outboard heating device |
| US3789190A (en) * | 1972-10-17 | 1974-01-29 | A J Matlen | Temperature regulation for electrical heater |
| US3902635A (en) | 1973-03-05 | 1975-09-02 | Walter J Jinotti | Fluid dispensing apparatus |
| US4042153A (en) | 1973-03-14 | 1977-08-16 | Standard Oil Company | Liquid dropping device |
| US3847304A (en) | 1973-08-13 | 1974-11-12 | M Cohen | Bag-type fluid and paste dispenser |
| US3967001A (en) | 1973-11-01 | 1976-06-29 | The United States Of America As Represented By The Secretary Of The Army | Process of preparing a secondary electron emissive coating on the interior walls of a microchannel plate |
| US3987941A (en) | 1973-12-14 | 1976-10-26 | Blessing Alfred V | Preserving container for liquid food substances |
| US3903883A (en) | 1974-04-17 | 1975-09-09 | Respiratory Care | Variable aerosol heater with automatic temperature control |
| US3904083A (en) | 1974-04-19 | 1975-09-09 | Gen Electric | Self-sealing viscous material dispenser loading apparatus |
| US4077542A (en) | 1974-12-02 | 1978-03-07 | Petterson Tor H | Unattended aerosol dispenser |
| US3993246A (en) | 1975-06-19 | 1976-11-23 | Erb Elisha | Nebulizer and method |
| US4060082A (en) | 1976-08-16 | 1977-11-29 | Mpl, Inc. | Dual-ingredient medication dispenser |
| US4161281A (en) | 1976-08-30 | 1979-07-17 | Erb Elisha | Pneumatic nebulizer and method |
| NL165639C (en) | 1977-03-02 | 1981-05-15 | Evert Jacob Sybren Bron | PIPE FOR CIGARETTES, CIGARS AND OTHER TOBACCO APPLIANCES WITH AN SMOOTH THREADED IN THE SMOKE. |
| US4162501A (en) | 1977-08-08 | 1979-07-24 | Silonics, Inc. | Ink supply system for an ink jet printer |
| US4258073A (en) | 1978-03-02 | 1981-03-24 | Payne John M | Taking of finger prints |
| US4231492A (en) | 1978-03-14 | 1980-11-04 | Oatey Co. | Apparatus and method for dispensing putty-like material |
| US4261356A (en) | 1978-10-23 | 1981-04-14 | Baxter Travenol Laboratories, Inc. | Method and apparatus for controlling the dispensing of fluid |
| US4289003A (en) | 1979-05-10 | 1981-09-15 | Yang Tayhugh L | Key holder |
| GB2050303B (en) | 1979-05-21 | 1983-03-02 | Rhen Beteiligung Finanz | Dispensing valve |
| US4291838A (en) | 1979-12-26 | 1981-09-29 | C. R. Bard, Inc. | Nebulizer and associated heater |
| US4471892A (en) | 1980-02-11 | 1984-09-18 | Fabricated Metals, Inc. | Material container having a flexible follower |
| US4303083A (en) | 1980-10-10 | 1981-12-01 | Burruss Jr Robert P | Device for evaporation and inhalation of volatile compounds and medications |
| US4383171A (en) | 1980-11-17 | 1983-05-10 | The United States Of America As Represented By The Administrator Of The National Aeronautics And Space Administration | Particle analyzing method and apparatus |
| US4391308A (en) | 1981-04-16 | 1983-07-05 | Steiner Corporation | Soap dispensing system |
| US4395303A (en) | 1981-04-22 | 1983-07-26 | Masco Corporation | Method of manufacturing thin-walled corrosion resistant metallic objects |
| GR79615B (en) | 1982-10-08 | 1984-10-31 | Glaxo Group Ltd | |
| US4512341A (en) | 1982-11-22 | 1985-04-23 | Lester Victor E | Nebulizer with capillary feed |
| US4682010A (en) | 1983-03-07 | 1987-07-21 | Safeway Products, Inc. | In-line electric heater for an aerosol delivery system |
| US4730111A (en) | 1983-08-30 | 1988-03-08 | Research Corporation | Ion vapor source for mass spectrometry of liquids |
| US4649911A (en) | 1983-09-08 | 1987-03-17 | Baylor College Of Medicine | Small particle aerosol generator for treatment of respiratory disease including the lungs |
| US4575609A (en) | 1984-03-06 | 1986-03-11 | The United States Of America As Represented By The United States Department Of Energy | Concentric micro-nebulizer for direct sample insertion |
| IT1196142B (en) | 1984-06-11 | 1988-11-10 | Sicor Spa | PROCEDURE FOR THE PREPARATION OF 16.17-ACETALS OF PREGNANIC DERIVATIVES AND NEW COMPOUNDS OBTAINED |
| US4762995A (en) | 1984-06-22 | 1988-08-09 | Georgia Tech Research Corporation | Monodisperse aerosol generator |
| EP0181092B1 (en) | 1984-10-04 | 1993-01-13 | I J & L A TETLEY MANUFACTURING PTY LTD | Apparatus for producing a diagnostic gas composition |
| US4744932A (en) | 1985-05-31 | 1988-05-17 | Celanese Corporation | Process for forming a skinless hollow fiber of a cellulose ester |
| US4700657A (en) | 1985-07-10 | 1987-10-20 | Print-Lock Corporation | Fingerprinting system incorporating a spray container and a portable vapor tank |
| CH672600A5 (en) | 1985-07-30 | 1989-12-15 | Glaxo Group Ltd | |
| US5133343A (en) | 1985-08-09 | 1992-07-28 | Johnson Iv John J | Apparatus for supporting an inhaler |
| JPS62153370A (en) | 1985-12-27 | 1987-07-08 | Alpha Giken:Kk | 2-cyanoacrylate composition |
| GB8604328D0 (en) | 1986-02-21 | 1986-03-26 | Ici Plc | Producing spray of droplets of liquid |
| US4837260A (en) | 1986-05-23 | 1989-06-06 | Toagosei Chemical Industry Co., Ltd. | Cyanoacrylate compositions |
| US4926852B1 (en) | 1986-06-23 | 1995-05-23 | Univ Johns Hopkins | Medication delivery system phase one |
| US4790305A (en) | 1986-06-23 | 1988-12-13 | The Johns Hopkins University | Medication delivery system |
| US4776515A (en) | 1986-08-08 | 1988-10-11 | Froughieh Michalchik | Electrodynamic aerosol generator |
| DE3627222A1 (en) | 1986-08-11 | 1988-02-18 | Siemens Ag | ULTRASONIC POCKET SPRAYER |
| US4735217A (en) | 1986-08-21 | 1988-04-05 | The Procter & Gamble Company | Dosing device to provide vaporized medicament to the lungs as a fine aerosol |
| US4819834A (en) | 1986-09-09 | 1989-04-11 | Minnesota Mining And Manufacturing Company | Apparatus and methods for delivering a predetermined amount of a pressurized fluid |
| GB8713645D0 (en) | 1987-06-11 | 1987-07-15 | Imp Tobacco Ltd | Smoking device |
| US5322057A (en) | 1987-07-08 | 1994-06-21 | Vortran Medical Technology, Inc. | Intermittent signal actuated nebulizer synchronized to operate in the exhalation phase, and its method of use |
| US4871115A (en) | 1987-08-24 | 1989-10-03 | Hessey B Russell | Smoke generating apparatus |
| US4935624A (en) | 1987-09-30 | 1990-06-19 | Cornell Research Foundation, Inc. | Thermal-assisted electrospray interface (TAESI) for LC/MS |
| US4819625A (en) | 1987-11-12 | 1989-04-11 | Cimco, Inc. | Nebulizer heater |
| US5063921A (en) | 1987-11-12 | 1991-11-12 | Cimco, Inc. | Nebulizer heater |
| US5259370A (en) * | 1987-11-12 | 1993-11-09 | Cimco, Inc. | Nebulizer heater |
| CH675216A5 (en) | 1987-11-30 | 1990-09-14 | Alphasem Ag | |
| US4911157A (en) | 1988-01-07 | 1990-03-27 | Pegasus Research Corporation | Self-regulating, heated nebulizer system |
| US5021802A (en) | 1988-02-19 | 1991-06-04 | Dataproducts Corporation | Thermally reversible sol-gel phase change ink or bubble jet ink |
| US4871623A (en) | 1988-02-19 | 1989-10-03 | Minnesota Mining And Manufacturing Company | Sheet-member containing a plurality of elongated enclosed electrodeposited channels and method |
| EP0358114A3 (en) | 1988-09-08 | 1990-11-14 | R.J. Reynolds Tobacco Company | Aerosol delivery articles utilizing electrical energy |
| US4922901A (en) | 1988-09-08 | 1990-05-08 | R. J. Reynolds Tobacco Company | Drug delivery articles utilizing electrical energy |
| US4947875A (en) | 1988-09-08 | 1990-08-14 | R. J. Reynolds Tobacco Company | Flavor delivery articles utilizing electrical energy |
| US4992206A (en) | 1988-11-01 | 1991-02-12 | Lowndes Engineering Co., Inc. | Aerosol generator apparatus and method of use |
| EP0373237A1 (en) | 1988-12-13 | 1990-06-20 | Siemens Aktiengesellschaft | Pocket inhaler device |
| DE3908161A1 (en) | 1989-03-13 | 1990-09-27 | Bat Cigarettenfab Gmbh | Smokable article |
| US4982097A (en) | 1989-05-19 | 1991-01-01 | Battelle Memorial Institute | Vaporization device for continuous introduction of liquids into a mass spectrometer |
| US4941483A (en) | 1989-09-18 | 1990-07-17 | R. J. Reynolds Tobacco Company | Aerosol delivery article |
| SE8903219D0 (en) | 1989-10-02 | 1989-10-02 | Astra Ab | PROCESS FOR THE MANUFACTURE OF BUDESONIDE |
| US5226441A (en) | 1989-11-13 | 1993-07-13 | Cmb Industries | Backflow preventor with adjustable outflow direction |
| US5144962A (en) | 1989-12-01 | 1992-09-08 | Philip Morris Incorporated | Flavor-delivery article |
| US5060671A (en) * | 1989-12-01 | 1991-10-29 | Philip Morris Incorporated | Flavor generating article |
| US5056511A (en) * | 1989-12-14 | 1991-10-15 | Juergen L. Fischer | Method and apparatus for compressing, atomizing, and spraying liquid substances |
| US5231983A (en) | 1990-01-03 | 1993-08-03 | Minnesota Mining And Manufacturing | Method of and apparatus for the aerosol administration of medication |
| US5044565A (en) | 1990-03-13 | 1991-09-03 | The Board Of Regents Of The University Of Nebrasaka | Forming fine particles |
| US5096092A (en) | 1990-03-13 | 1992-03-17 | Mmm, Ltd. | Food dispensing apparatus utilizing inflatable bladder |
| SG45171A1 (en) | 1990-03-21 | 1998-01-16 | Boehringer Ingelheim Int | Atomising devices and methods |
| US4978837A (en) * | 1990-04-13 | 1990-12-18 | Central Plastics Company | Method and apparatus for electrically heat welding thermoplastic fittings |
| DE4012849A1 (en) | 1990-04-23 | 1991-10-24 | Alfill Getraenketechnik | DEVICE FOR FILLING CONTAINERS WITH A LIQUID |
| BE1004267A3 (en) | 1990-05-18 | 1992-10-20 | Aurinco Holdings Ltd | Self-supporting mirror and manufacturing method of its. |
| DE59103399D1 (en) | 1990-06-21 | 1994-12-08 | Wilhelm A Keller | Discharge cartridge with storage cylinder and delivery piston. |
| FR2667254B1 (en) | 1990-09-27 | 1992-10-30 | Commissariat Energie Atomique | PNEUMATIC NEBULIZER. |
| US5217004A (en) | 1990-12-13 | 1993-06-08 | Tenax Corporation | Inhalation actuated dispensing apparatus |
| US5505214A (en) | 1991-03-11 | 1996-04-09 | Philip Morris Incorporated | Electrical smoking article and method for making same |
| CA2065724A1 (en) | 1991-05-01 | 1992-11-02 | Thomas R. Anthony | Method of producing articles by chemical vapor deposition and the support mandrels used therein |
| AU666852B2 (en) | 1991-05-01 | 1996-02-29 | Henry M. Jackson Foundation For The Advancement Of Military Medicine | A method for treating infectious respiratory diseases |
| JP3230056B2 (en) | 1991-07-02 | 2001-11-19 | インヘイル・インコーポレーテッド | Device for forming an aerosolized dose of a drug |
| US5230445A (en) | 1991-09-30 | 1993-07-27 | City Of Hope | Micro delivery valve |
| CA2123909C (en) | 1991-12-18 | 2002-10-01 | Christer Carl Gustav Carling | New combination of formoterol and budesonide |
| JP2902197B2 (en) | 1992-02-04 | 1999-06-07 | 株式会社日立製作所 | Atmospheric pressure ionization mass spectrometer |
| HU207457B (en) | 1992-02-07 | 1993-04-28 | Geza Bolla | Method and device for medicine atomizing carrying out by ultrasonic sound |
| BR9307141A (en) | 1992-09-29 | 1999-03-30 | Inhale Therapeutic Syst | Process for the pulsatile sistance release of an active fragment of parathyroid hormone (PTH) to a mammalian host and to a patient and pharmaceutical composition |
| US5349946A (en) | 1992-10-07 | 1994-09-27 | Mccomb R Carter | Microprocessor controlled flow regulated molecular humidifier |
| US5299565A (en) * | 1992-10-19 | 1994-04-05 | Brown James N | Portable nebulizer apparatus |
| US5327915A (en) | 1992-11-13 | 1994-07-12 | Brown & Williamson Tobacco Corp. | Smoking article |
| US5342180A (en) | 1992-11-17 | 1994-08-30 | Ivac Corporation | Pump mechanism having a drive motor with an external rotor |
| SE9203743D0 (en) | 1992-12-11 | 1992-12-11 | Astra Ab | EFFICIENT USE |
| US6024090A (en) | 1993-01-29 | 2000-02-15 | Aradigm Corporation | Method of treating a diabetic patient by aerosolized administration of insulin lispro |
| US5970973A (en) | 1993-01-29 | 1999-10-26 | Aradigm Corporation | Method of delivering insulin lispro |
| US5743250A (en) | 1993-01-29 | 1998-04-28 | Aradigm Corporation | Insulin delivery enhanced by coached breathing |
| US6098620A (en) | 1993-01-29 | 2000-08-08 | Aradigm Corporation | Device for aerosolizing narcotics |
| US6131567A (en) | 1993-01-29 | 2000-10-17 | Aradigm Corporation | Method of use of monomeric insulin as a means for improving the reproducibility of inhaled insulin |
| US5934272A (en) | 1993-01-29 | 1999-08-10 | Aradigm Corporation | Device and method of creating aerosolized mist of respiratory drug |
| US5915378A (en) | 1993-01-29 | 1999-06-29 | Aradigm Corporation | Creating an aerosolized formulation of insulin |
| US5888477A (en) | 1993-01-29 | 1999-03-30 | Aradigm Corporation | Use of monomeric insulin as a means for improving the bioavailability of inhaled insulin |
| US5395445A (en) | 1993-05-20 | 1995-03-07 | Bohanan; Arthur M. | Method and apparatus for detecting fingerprints on skin |
| US5497763A (en) | 1993-05-21 | 1996-03-12 | Aradigm Corporation | Disposable package for intrapulmonary delivery of aerosolized formulations |
| US5744557A (en) | 1993-06-16 | 1998-04-28 | Minnesota Mining And Manufacturing Company | Energy-curable cyanate/ethylenically unsaturated compositions |
| CH686872A5 (en) | 1993-08-09 | 1996-07-31 | Disetronic Ag | Medical Inhalationsgeraet. |
| US5342645A (en) | 1993-09-15 | 1994-08-30 | Minnesota Mining And Manufacturing Company | Metal complex/cyanoacrylate compositions useful in latent fingerprint development |
| WO1995008361A1 (en) | 1993-09-21 | 1995-03-30 | Abbott Laboratories | A system for connecting an inhalation agent container to a vaporizer |
| DE4332394A1 (en) | 1993-09-23 | 1995-03-30 | Falk Pharma Gmbh | Controlled release budesonide pellets and method of making the same |
| US5421489A (en) | 1994-01-12 | 1995-06-06 | Steiner Company, Inc. | Push-type soap dispenser |
| DE4414708A1 (en) | 1994-04-27 | 1995-11-02 | Henkel Ecolab Gmbh & Co Ohg | Method and device for emptying a container filled with a thixotropic paste |
| ES2245780T3 (en) | 1994-05-18 | 2006-01-16 | Nektar Therapeutics | METHODS AND COMPOSITIONS FOR THE FORMULATION OF INTERFERONS AS A DRY POWDER. |
| US5462597A (en) | 1994-06-30 | 1995-10-31 | Minnesota Mining And Manufacturing | System for inkless fingerprinting |
| CA2555600C (en) | 1994-09-21 | 2008-01-29 | Nektar Therapeutics | Apparatus and methods for dispersing dry powder medicaments |
| US5522385A (en) | 1994-09-27 | 1996-06-04 | Aradigm Corporation | Dynamic particle size control for aerosolized drug delivery |
| FI96384C (en) | 1994-10-18 | 1996-06-25 | Instrumentarium Oy | Apparatus for filling an anesthesia vaporizer |
| JP3420359B2 (en) | 1994-10-21 | 2003-06-23 | ダイセル化学工業株式会社 | Filter material for tobacco smoke, fibrous cellulose ester and method for producing the same |
| JPH08142801A (en) * | 1994-11-24 | 1996-06-04 | Mitsubishi Electric Corp | Alternator electric supply type electric heating device |
| DE4446891A1 (en) | 1994-12-27 | 1996-07-04 | Falk Pharma Gmbh | Stable aqueous budesonide solution |
| US5970974A (en) | 1995-03-14 | 1999-10-26 | Siemens Aktiengesellschaft | Dosating unit for an ultrasonic atomizer device |
| DE19510690A1 (en) | 1995-03-14 | 1996-09-19 | Schering Ag | Polymeric nano- and / or microparticles, processes for their production, and use in medical diagnostics and therapy |
| JPH08264260A (en) * | 1995-03-24 | 1996-10-11 | Sumitomo Metal Ind Ltd | Direct electrification heating device and direct electrification heating method |
| US6205999B1 (en) | 1995-04-05 | 2001-03-27 | Aerogen, Inc. | Methods and apparatus for storing chemical compounds in a portable inhaler |
| US6085740A (en) | 1996-02-21 | 2000-07-11 | Aerogen, Inc. | Liquid dispensing apparatus and methods |
| US6014970A (en) | 1998-06-11 | 2000-01-18 | Aerogen, Inc. | Methods and apparatus for storing chemical compounds in a portable inhaler |
| US5474059A (en) | 1995-04-08 | 1995-12-12 | Cooper; Guy F. | Aerosol dispensing apparatus for dispensing a medicated vapor into the lungs of a patient |
| US6136346A (en) | 1995-04-14 | 2000-10-24 | Inhale Therapeutic Systems | Powdered pharmaceutical formulations having improved dispersibility |
| US6258341B1 (en) | 1995-04-14 | 2001-07-10 | Inhale Therapeutic Systems, Inc. | Stable glassy state powder formulations |
| US6165463A (en) | 1997-10-16 | 2000-12-26 | Inhale Therapeutic Systems, Inc. | Dispersible antibody compositions and methods for their preparation and use |
| GB9508691D0 (en) | 1995-04-28 | 1995-06-14 | Pafra Ltd | Stable compositions |
| US5587582A (en) | 1995-05-19 | 1996-12-24 | Cornell Research Foundation, Inc. | Self-aligning liquid junction |
| US5575929A (en) | 1995-06-05 | 1996-11-19 | The Regents Of The University Of California | Method for making circular tubular channels with two silicon wafers |
| WO1997002856A1 (en) | 1995-07-10 | 1997-01-30 | A & D Company, Limited | Handy atomizer |
| US5872010A (en) | 1995-07-21 | 1999-02-16 | Northeastern University | Microscale fluid handling system |
| US5565677A (en) | 1995-08-04 | 1996-10-15 | The University Of Delaware | Aerodynamic nozzle for aerosol particle beam formation into a vacuum |
| US5617844A (en) | 1995-09-21 | 1997-04-08 | King; Russell W. | Aerosol medication delivery system |
| US6132580A (en) | 1995-09-28 | 2000-10-17 | The Regents Of The University Of California | Miniature reaction chamber and devices incorporating same |
| SE505095C2 (en) | 1995-10-02 | 1997-06-23 | Engstrom Medical Ab | Apparatus for gasification of liquid and dosing of gas thus produced |
| US5564442A (en) | 1995-11-22 | 1996-10-15 | Angus Collingwood MacDonald | Battery powered nicotine vaporizer |
| DE19545257A1 (en) | 1995-11-24 | 1997-06-19 | Schering Ag | Process for the production of morphologically uniform microcapsules and microcapsules produced by this process |
| US5839430A (en) | 1996-04-26 | 1998-11-24 | Cama; Joseph | Combination inhaler and peak flow rate meter |
| US5826633A (en) | 1996-04-26 | 1998-10-27 | Inhale Therapeutic Systems | Powder filling systems, apparatus and methods |
| ES2140998B1 (en) | 1996-05-13 | 2000-10-16 | Univ Sevilla | LIQUID ATOMIZATION PROCEDURE. |
| US6187214B1 (en) | 1996-05-13 | 2001-02-13 | Universidad De Seville | Method and device for production of components for microfabrication |
| US6189803B1 (en) | 1996-05-13 | 2001-02-20 | University Of Seville | Fuel injection nozzle and method of use |
| US6116516A (en) | 1996-05-13 | 2000-09-12 | Universidad De Sevilla | Stabilized capillary microjet and devices and methods for producing same |
| US5743251A (en) | 1996-05-15 | 1998-04-28 | Philip Morris Incorporated | Aerosol and a method and apparatus for generating an aerosol |
| GB9610821D0 (en) | 1996-05-23 | 1996-07-31 | Glaxo Wellcome Inc | Metering apparatus |
| US6103270A (en) | 1996-06-07 | 2000-08-15 | Inhale Therapeutic Systems | Methods and system for processing dispersible fine powders |
| US6158676A (en) | 1996-06-21 | 2000-12-12 | Hughes Technology Group, L.L.C. | Micro-atomizing device |
| JP3554138B2 (en) * | 1996-06-28 | 2004-08-18 | キヤノン株式会社 | Ink jet recording method, ink jet recording head, and ink jet recording apparatus |
| DE19641750A1 (en) | 1996-10-10 | 1998-04-23 | Henkel Ecolab Gmbh & Co Ohg | Pot with flexible storage container and follower plate |
| US5906202A (en) | 1996-11-21 | 1999-05-25 | Aradigm Corporation | Device and method for directing aerosolized mist to a specific area of the respiratory tract |
| US6131570A (en) | 1998-06-30 | 2000-10-17 | Aradigm Corporation | Temperature controlling device for aerosol drug delivery |
| US5878752A (en) | 1996-11-25 | 1999-03-09 | Philip Morris Incorporated | Method and apparatus for using, cleaning, and maintaining electrical heat sources and lighters useful in smoking systems and other apparatuses |
| US5944025A (en) | 1996-12-30 | 1999-08-31 | Brown & Williamson Tobacco Company | Smokeless method and article utilizing catalytic heat source for controlling products of combustion |
| JP2001507701A (en) | 1996-12-31 | 2001-06-12 | インヘイル・セラピューティック・システムズ・インコーポレーテッド | Method for spray drying a solution of a hydrophobic drug having a hydrophilic excipient and a composition made by the method |
| US6192882B1 (en) | 1997-02-24 | 2001-02-27 | Aradigm Corporation | Formulation and devices for monitoring the efficacy of the delivery of aerosols |
| GB9704961D0 (en) | 1997-03-11 | 1997-04-30 | Aerogen Co Ltd | Burner assemblies |
| SE510741E (en) | 1997-04-07 | 2008-03-28 | Gibeck Ab Louis | Apparatus and method for supplying treatment gas to man or animals by gasification of treatment fluid |
| US5932315A (en) | 1997-04-30 | 1999-08-03 | Hewlett-Packard Company | Microfluidic structure assembly with mating microfeatures |
| US5756995A (en) | 1997-07-09 | 1998-05-26 | The United States Of America As Represented By The Secretary Of The Army | Ion interface for mass spectrometer |
| US6182712B1 (en) | 1997-07-21 | 2001-02-06 | Inhale Therapeutic Systems | Power filling apparatus and methods for their use |
| KR100289448B1 (en) | 1997-07-23 | 2001-05-02 | 미즈노 마사루 | Flavor generator |
| US5993633A (en) | 1997-07-31 | 1999-11-30 | Battelle Memorial Institute | Capillary electrophoresis electrospray ionization mass spectrometry interface |
| US6290685B1 (en) | 1998-06-18 | 2001-09-18 | 3M Innovative Properties Company | Microchanneled active fluid transport devices |
| SE9703290D0 (en) * | 1997-09-11 | 1997-09-11 | Siemens Elema Ab | ventilator |
| US6345617B1 (en) * | 1997-09-26 | 2002-02-12 | 1263152 Ontario Inc. | Aerosol medication delivery apparatus and system |
| US5855202A (en) | 1997-10-08 | 1999-01-05 | Andrade; Joseph R. | Aerosol holding chamber for a metered-dose inhaler |
| US5954979A (en) | 1997-10-16 | 1999-09-21 | Philip Morris Incorporated | Heater fixture of an electrical smoking system |
| US6016800A (en) * | 1997-10-24 | 2000-01-25 | Century; Theodore J. | Intrapulmonary aerosolizer |
| US6159188A (en) | 1998-01-14 | 2000-12-12 | Robert L. Rogers | Apparatus and method for delivery of micro and submicro quantities of materials |
| US6054032A (en) | 1998-01-27 | 2000-04-25 | 3M Innovative Properties Company | Capillary electrophoresis array |
| US6223746B1 (en) | 1998-02-12 | 2001-05-01 | Iep Pharmaceutical Devices Inc. | Metered dose inhaler pump |
| US6158431A (en) | 1998-02-13 | 2000-12-12 | Tsi Incorporated | Portable systems and methods for delivery of therapeutic material to the pulmonary system |
| US6257233B1 (en) | 1998-06-04 | 2001-07-10 | Inhale Therapeutic Systems | Dry powder dispersing apparatus and methods for their use |
| US6260549B1 (en) | 1998-06-18 | 2001-07-17 | Clavius Devices, Inc. | Breath-activated metered-dose inhaler |
| US6095153A (en) | 1998-06-19 | 2000-08-01 | Kessler; Stephen B. | Vaporization of volatile materials |
| US6276347B1 (en) | 1998-09-25 | 2001-08-21 | Micro Coating Technologies, Inc. | Systems and methods for delivering atomized fluids |
| US6234167B1 (en) | 1998-10-14 | 2001-05-22 | Chrysalis Technologies, Incorporated | Aerosol generator and methods of making and using an aerosol generator |
| US6070575A (en) | 1998-11-16 | 2000-06-06 | Aradigm Corporation | Aerosol-forming porous membrane with certain pore structure |
| US6164630A (en) | 1998-12-18 | 2000-12-26 | Honeywell Inc. | Portable humidifier with water treatment substance dispenser |
| US6053176A (en) | 1999-02-23 | 2000-04-25 | Philip Morris Incorporated | Heater and method for efficiently generating an aerosol from an indexing substrate |
| US6288360B1 (en) | 1999-07-14 | 2001-09-11 | Aradigm Corporation | Excimer laser ablation process control of multilaminate materials |
| US6235177B1 (en) | 1999-09-09 | 2001-05-22 | Aerogen, Inc. | Method for the construction of an aperture plate for dispensing liquid droplets |
| US6295986B1 (en) | 2000-01-12 | 2001-10-02 | Aradigm Corporation | Reactive ion etching method of fabricating nozzles for aerosolized delivery of therapeutic or diagnostic agents |
| TWI239251B (en) * | 2001-07-31 | 2005-09-11 | Chrysalis Tech Inc | Method and apparatus for generating a volatilized liquid |
| US7430111B2 (en) | 2005-01-04 | 2008-09-30 | Lg Electronics Inc. | Mounting structure for display unit in refrigerator |
| DE102007060312B4 (en) | 2007-08-24 | 2012-12-06 | W.E.T. Automotive Systems Ag | Electrothermal transducer and tempering device |
-
2000
- 2000-12-22 US US09/742,322 patent/US6501052B2/en not_active Expired - Lifetime
-
2001
- 2001-12-03 CN CNB018227554A patent/CN100342753C/en not_active Expired - Lifetime
- 2001-12-03 EP EP01984945.4A patent/EP1346606B1/en not_active Expired - Lifetime
- 2001-12-03 AU AU2002233945A patent/AU2002233945A1/en not_active Abandoned
- 2001-12-03 JP JP2002552609A patent/JP4339590B2/en not_active Expired - Lifetime
- 2001-12-03 CA CA2432081A patent/CA2432081C/en not_active Expired - Lifetime
- 2001-12-03 WO PCT/US2001/045257 patent/WO2002051468A2/en active Application Filing
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2002
- 2002-10-24 US US10/279,035 patent/US7173222B2/en not_active Expired - Lifetime
-
2009
- 2009-03-19 JP JP2009069033A patent/JP2009172392A/en active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| EP1346606A2 (en) | 2003-09-24 |
| JP2004516101A (en) | 2004-06-03 |
| CN1491525A (en) | 2004-04-21 |
| US20020079309A1 (en) | 2002-06-27 |
| US20030132219A1 (en) | 2003-07-17 |
| WO2002051468A2 (en) | 2002-07-04 |
| CN100342753C (en) | 2007-10-10 |
| JP2009172392A (en) | 2009-08-06 |
| US7173222B2 (en) | 2007-02-06 |
| WO2002051468A3 (en) | 2003-01-23 |
| AU2002233945A1 (en) | 2002-07-08 |
| JP4339590B2 (en) | 2009-10-07 |
| EP1346606B1 (en) | 2021-04-21 |
| CA2432081C (en) | 2013-06-04 |
| EP1346606A4 (en) | 2004-09-01 |
| US6501052B2 (en) | 2002-12-31 |
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