CA2410990A1 - Systems and methods for topical treatment with nitric oxide - Google Patents

Systems and methods for topical treatment with nitric oxide Download PDF

Info

Publication number
CA2410990A1
CA2410990A1 CA002410990A CA2410990A CA2410990A1 CA 2410990 A1 CA2410990 A1 CA 2410990A1 CA 002410990 A CA002410990 A CA 002410990A CA 2410990 A CA2410990 A CA 2410990A CA 2410990 A1 CA2410990 A1 CA 2410990A1
Authority
CA
Canada
Prior art keywords
acid
gel
ointment
salt
composition
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA002410990A
Other languages
French (fr)
Other versions
CA2410990C (en
Inventor
William A. Seitz
Robert E. Garfield
Alexandru T. Balaban
Randall J. Stewart
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Nitric Oxide Solutions
Original Assignee
Nitric Oxide Solutions
William A. Seitz
Robert E. Garfield
Alexandru T. Balaban
Randall J. Stewart
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=22250448&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CA2410990(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Nitric Oxide Solutions, William A. Seitz, Robert E. Garfield, Alexandru T. Balaban, Randall J. Stewart filed Critical Nitric Oxide Solutions
Publication of CA2410990A1 publication Critical patent/CA2410990A1/en
Application granted granted Critical
Publication of CA2410990C publication Critical patent/CA2410990C/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/12—Carboxylic acids; Salts or anhydrides thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0014—Skin, i.e. galenical aspects of topical compositions

Abstract

A simple, biocompatible system and procedure for generating nitric oxide (NO) is described. A mixture of powdered sodium nitrite, ascorbic acid, and maleic acid (or another organic acid of adequate strength) immediately generates nitric oxide (NO) on treatment with water. To slow down the NO generation, one may prepare an ointment from a nonaqueous medium (petrolatum, Vaseline(TM)) and the three powdered ingredients, which on being applied topically on the skin will release NO as water permeates through this medium; alternatively, one may convert the aqueous sodium nitrite solution into a gel with hydroxyethylcellulose (or other gel-forming compound) and combine this gel with another gel obtained from aqueous ascorbic and maleic acids with hydroxyethylcellulose for topical application (on intact skin, burns intra-cavity, burns, intra-cavity, etc.). The two gels may be admixed immediately before use (possibly from a single container with separate chambers and dual nozzle, via pushing or squeezing the two gels through the nozzle), or may be applied in sandwich-like fashion (possibly as a transdermal patch) for further slowing down the delivery of NO.

Claims (35)

1. A method for therapeutically applying NO, the method comprising combining a nitrite salt, a biocompatible reluctant and an acid with a pKa between about 1 and about 4 in a medium and topically applying said combination to a body site.
2. A method for topical delivery of nitric oxide (NO) comprising mixing a powdered nitrite salt with a powdered reluctant and an acid having a pKa between about 1 and about 4 in a diffusion-inhibiting topically applicable medium and topically applying an effective amount of said mixture to a body site.
3. The method of claim 1 or 2 where the reluctant is an ascorbate salt, an erythrobate or .alpha.-tocopherol.
4. The method of claim 1 or 2 where the reluctant is ascorbic acid.
5. The method of claim 1 or 2 where thewhere the acid is an organic acid.
6. The method of claim 1 or 2 where the acid is maleic acid.
7. The method of claim 1 or 2 where the acid is an inorganic acid.
8. The method of claim 1 or 2 where the nitrite salt is an inorganic salt.
9. The method of claim 1 or 2 where the nitrite salt is sodium nitrite.
10. The method of claim 1 or 2 where the medium is an aqueous gel.
11. The method of claim 1 or 2 where the medium comprises hydroxyethyl cellulose or poloxama.
12. The method of claim 1 or 2 where the medium is an organic salve.
13. A topically applicable ointment for controlled NO delivery comprising a nitrite salt, a reluctant and an acid with a pka between about 1 and about 4 in/a medium sufficiently viscous to inhibit diffusion, permit slow NO release and facilitate topical application.
14. The ointment of claim 12 where the reluctant is ascorbic acid, an ascorbate salt, an erythrobate or .alpha.-tocopherol.
15. The ointment of claim 12 where the reluctant is ascorbic acid.
16. The ointment of claim 12 where the acid is an organic acid.
17. The ointment of claim 12 where the acid is maleic acid.
18. The ointment of claim 12 where the acid is an inorganic acid.
19. The ointment of claim 12 where the nitrite salt is an inorganic salt.
20. The ointment of claim 12 where the nitrite salt is sodium nitrite.
21. The ointment of claim 12 where the medium is an aqueous gel.
22. The ointment of claim 12 where the medium is an organic salve.
23. A composition for generating and controlling the release rate of NO for topical applications comprising a first aqueous gel and a second aqueous gel, the first gel comprising a nitrite salt, and the second gel comprising an acid having a pka between about 1 and about 4 and at least one of the first and second gel comprising a reluctant.
24. The composition of claim 22 where the reluctant is ascorbic acid, an ascorbate salt, an erythrobate or .alpha.-tocopherol.
25. The composition of claim 22 where the reductant is ascorbic acid.
26. The composition of claim 22 where thewhere the acid is an organic acid.
27. The composition of claim 22 where the acid is maleic acid.
28. The composition of claim 22 where the acid is an inorganic acid.
29. The composition of claim 22 where the nitrite salt is an inorganic salt.
30. The composition of claim 22 where the nitrite salt is sodium nitrite.
31. A method for delivering the two gels of the composition of claim 22 from a single container with two separate chambers by forcing them through a nozzle with a hole for each chamber.
32. A method for topical application of the gels of the composition of claim 22 in layers, with the nitrite-containing gel layer being in contact with the skin, the second gel layer being separated from the first by an impermeable plastic or metal foil until just before use, when the plastic or foil is removed, and the gel layers are topically applied.
33. A method in which the ointment of claim 12 or the two gels of the composition of claim 22 are applied on the skin through an interposed gas-permeable membrane for lessening any skin irritation.
34. A gel comprising a nitrite salt, an acid with a pKa between 1 and 4, and a reductant, for medical use.
35. A kit containing a first gel comprising a nitrite salt, a second gel comprising an acid with a pKa between 1 and 4, and a reductant in at least one of the first and second gels.
CA2410990A 1998-06-10 2000-05-24 Systems and methods for topical treatment with nitric oxide Expired - Fee Related CA2410990C (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US09/095,174 US6103275A (en) 1998-06-10 1998-06-10 Systems and methods for topical treatment with nitric oxide
PCT/US2000/014239 WO2001089572A1 (en) 1998-06-10 2000-05-24 Systems and methods for topical treatment with nitric oxide

Publications (2)

Publication Number Publication Date
CA2410990A1 true CA2410990A1 (en) 2001-11-29
CA2410990C CA2410990C (en) 2011-08-02

Family

ID=22250448

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2410990A Expired - Fee Related CA2410990C (en) 1998-06-10 2000-05-24 Systems and methods for topical treatment with nitric oxide

Country Status (7)

Country Link
US (2) US6103275A (en)
EP (1) EP1283724B1 (en)
AT (1) ATE430584T1 (en)
AU (2) AU2000250426B2 (en)
CA (1) CA2410990C (en)
DE (1) DE60042174D1 (en)
WO (1) WO2001089572A1 (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2011085484A1 (en) * 2010-01-13 2011-07-21 Nitric Solutions Inc. Antimicrobial nitric oxide compositions

Families Citing this family (209)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6709681B2 (en) * 1995-02-17 2004-03-23 Aberdeen University Acidified nitrite as an antimicrobial agent
US7629384B2 (en) * 1997-09-17 2009-12-08 Strategic Science & Technologies, Llc Topical delivery of L-arginine to cause beneficial effects
US7914814B2 (en) * 1997-09-17 2011-03-29 Strategic Science & Technologies, Llc Topical delivery of arginine of cause beneficial effects
US6207713B1 (en) * 1997-09-17 2001-03-27 Eric T. Fossel Topical and oral delivery of arginine to cause beneficial effects
US6103275A (en) * 1998-06-10 2000-08-15 Nitric Oxide Solutions Systems and methods for topical treatment with nitric oxide
CA2254645A1 (en) * 1998-11-23 2000-05-23 Pulmonox Medical Corporation Method and apparatus for treatment of respiratory infections by nitric oxide inhalation
US20070086954A1 (en) * 1998-11-23 2007-04-19 Miller Christopher C Method and apparatus for treatment of respiratory infections by nitric oxide inhalation
GB9905425D0 (en) * 1999-03-09 1999-05-05 Queen Mary & Westfield College Pharmaceutical composition
US20050142218A1 (en) * 2000-03-09 2005-06-30 Queen Mary & Westfield College Pharmaceutical composition containing nitrate source and an acidifying agent for treating skin ischaemia
DE19945484A1 (en) * 1999-09-22 2001-04-05 Kolb Bachofen Victoria NO-releasing topically applicable composition
US7516742B2 (en) * 1999-11-24 2009-04-14 Cardinal Health 207, Inc. Method and apparatus for delivery of inhaled nitric oxide to spontaneous-breathing and mechanically-ventilated patients with intermittent dosing
US7678391B2 (en) * 2000-04-26 2010-03-16 Queen's University At Kingston Formulations and methods of using nitric oxide mimetics against a malignant cell phenotype
MXPA02010551A (en) 2000-04-26 2003-09-25 Univ Kingston Formulations and methods of using nitric oxide mimetics against a malignant cell phenotype.
US20050142217A1 (en) * 2000-04-26 2005-06-30 Adams Michael A. Formulations and methods of using nitric oxide mimetics against a malignant cell phenotype
GB0021317D0 (en) * 2000-08-30 2000-10-18 Queen Mary & Westfield College Transdermal pharmaceutical delivery composition
SE0004026D0 (en) * 2000-11-03 2000-11-03 Peter Wiklund New use
US7122018B2 (en) * 2000-12-26 2006-10-17 Sensormedics Corporation Device and method for treatment of wounds with nitric oxide
US6432077B1 (en) * 2000-12-26 2002-08-13 Sensormedics Corporation Device and method for treatment of surface infections with nitric oxide
US6706274B2 (en) * 2001-01-18 2004-03-16 Scimed Life Systems, Inc. Differential delivery of nitric oxide
GB0119011D0 (en) * 2001-08-03 2001-09-26 Univ Aberdeen Treatment of nail infections
WO2003020211A2 (en) * 2001-09-05 2003-03-13 Cyterra Corporation Nitric oxide generation
GB0125222D0 (en) * 2001-10-19 2001-12-12 Barts & London Nhs Trust Composition for the treatment of microbial infections
JP4475959B2 (en) * 2002-04-24 2010-06-09 インセンス・リミテッド Wound dressing containing hydrated hydrogels and enzymes
US20040018237A1 (en) * 2002-05-31 2004-01-29 Perricone Nicholas V. Topical drug delivery using phosphatidylcholine
US7531133B2 (en) * 2002-09-10 2009-05-12 Pulmonox Technologies Corporation Use of nitric oxide gas in an extracorporeal circuitry to treat blood plasma
GB0224986D0 (en) 2002-10-28 2002-12-04 Smith & Nephew Apparatus
CA2413834A1 (en) 2002-12-10 2004-06-10 1017975 Alberta Limited Nitric oxide gas generator
US9138707B2 (en) 2002-12-10 2015-09-22 Sy Kimball Portable, nitric oxide generator
CA2456035A1 (en) * 2003-02-03 2004-08-03 L'oreal Use of n-ary n-arylmethyleneiminodiacetates or n, n1-diarylmethylene ethylenediamineacetates as sources of no lmethylene ethylenediaminetriacetates
FR2850579B1 (en) * 2003-02-03 2006-08-18 Oreal USE OF MONO-OR DI-ESTERS OF CINNAMIC ACID OR ONE OF ITS DERIVATIVES AND VITAMIN C, AS DONOR OF NO
FR2850578B1 (en) * 2003-02-03 2006-07-28 Oreal USE OF N-ARYLMETHYLENE ETHYLENEDIAMINETRIACETATES, N-ARYLMETHYLENEIMINODIACETATES OR N, N'-DIARYLMETHYLENE ETHYLENEDIAMINEACETATES AS DONORS OF NO
CN1917836A (en) * 2003-04-23 2007-02-21 阿克伦大学 Sequestered reactive materials
US20050181026A1 (en) * 2003-06-09 2005-08-18 Insense Limited Skin dressings
GB0313217D0 (en) 2003-06-09 2003-07-16 Insense Ltd Improvements in or relating to skin dressings
AU2004253749B2 (en) * 2003-07-03 2010-04-01 The University Court Of The University Of St Andrews Zeolites for delivery of nitric oxide
WO2005004884A2 (en) 2003-07-09 2005-01-20 The Government Of The United States Of America As Represented By The Secretary, Department Of Health And Human Services Use of nitrite salts for the treatment of cardiovascular conditions
US20090136410A1 (en) * 2003-07-25 2009-05-28 Smith Daniel J Stabilization and ionic triggering of nitric oxide release
GB0322342D0 (en) * 2003-09-23 2003-10-22 Gamble Reed Skin patch
US11298453B2 (en) 2003-10-28 2022-04-12 Smith & Nephew Plc Apparatus and method for wound cleansing with actives
CN100475275C (en) * 2004-01-05 2009-04-08 董永华 Thromboembolism agent, storage and releasing device thereof
EP1813290A1 (en) * 2004-01-30 2007-08-01 Insense Limited Skin dressings comprising hydrated hydrogel lactate ions and glucose
ES2421142T3 (en) * 2004-02-23 2013-08-29 Strategic Science & Technologies, Llc Topical administration of a nitric oxide donor to improve body and skin appearance
US9226909B2 (en) 2004-04-19 2016-01-05 Strategic Science & Technologies, Llc Beneficial effects of increasing local blood flow
US20090105336A1 (en) * 2004-04-19 2009-04-23 Strategic Science & Technologies, Llc Beneficial Effects of Increasing Local Blood Flow
US20110028548A1 (en) * 2004-04-19 2011-02-03 Strategic Science & Technologies, Llc Beneficial effects of increasing local blood flow
ES2429443T3 (en) 2004-04-19 2013-11-14 Strategic Science & Technologies, Llc Transdermal supply of beneficial substances by means of an environment of high ionic strength
US8529548B2 (en) 2004-04-27 2013-09-10 Smith & Nephew Plc Wound treatment apparatus and method
GB0409446D0 (en) 2004-04-28 2004-06-02 Smith & Nephew Apparatus
US7753894B2 (en) 2004-04-27 2010-07-13 Smith & Nephew Plc Wound cleansing apparatus with stress
US10413644B2 (en) 2004-04-27 2019-09-17 Smith & Nephew Plc Wound treatment apparatus and method
US8518457B2 (en) * 2004-05-11 2013-08-27 Pulmonox Technologies Corporation Use of inhaled gaseous nitric oxide as a mucolytic agent or expectorant
CN1950120B (en) 2004-05-11 2010-10-20 伟亚医疗森迪斯公司 Intermittent dosing of nitric oxide gas
US7362274B1 (en) * 2004-07-09 2008-04-22 Huan-Cheng Lien Coupled feed-in butterfly shaped left/right hand circularly polarized microstrip antenna
EP1789119B1 (en) * 2004-08-18 2017-10-18 Geno LLC Conversion of nitrogen dioxide (no2) to nitric oxide (no)
US7618594B2 (en) * 2004-08-18 2009-11-17 Geno Llc Conversion of nitrogen dioxide (NO2) to nitric oxide (NO)
US20070260599A1 (en) * 2004-09-15 2007-11-08 Mcguire Heather A Social network analysis
US8577886B2 (en) * 2004-09-15 2013-11-05 Within3, Inc. Collections of linked databases
US8635217B2 (en) 2004-09-15 2014-01-21 Michael J. Markus Collections of linked databases
US8880521B2 (en) * 2004-09-15 2014-11-04 3Degrees Llc Collections of linked databases
US8412706B2 (en) 2004-09-15 2013-04-02 Within3, Inc. Social network analysis
US20070154570A1 (en) * 2004-09-29 2007-07-05 Miller Christopher C Use of nitric oxide in the treatment and disinfection of biofilms
GB0505035D0 (en) * 2005-03-11 2005-04-20 Insense Ltd Improvements relating to skin dressings
FR2883166B1 (en) * 2005-03-15 2007-05-18 Oreal ANHYDROUS COSMETIC COMPOSITION CONTAINING NITROGEN MONOXIDE IN MICROPOROUS CRYSTALLINE SOLID MATERIAL
WO2006097351A1 (en) * 2005-03-15 2006-09-21 L'oreal Anhydrous cosmetic composition comprising nitrogen monoxide in a microporous solid crystalline material
FR2883165B1 (en) * 2005-03-15 2007-05-18 Oreal ANHYDROUS COSMETIC COMPOSITION CONTAINING NITROGEN MONOXIDE IN MICROPOROUS CRYSTALLINE SOLID MATERIAL
WO2006097349A1 (en) * 2005-03-15 2006-09-21 L'oreal Cosmetic use of a microporous solid crystalline material no for improving the natural colouring and/or appearance of the skin and/or lips
WO2006097352A1 (en) * 2005-03-15 2006-09-21 L'oreal Cosmetic composition containing nitrogen monoxide in a microporous crystalline solid material
FR2883163B1 (en) * 2005-03-15 2007-05-18 Oreal COSMETIC USE OF MICROPOROUS MICROPOROUS SOLID STATE MATERIAL CONTAINING NO TO IMPROVE THE APPEARANCE AND / OR NATURAL COLORING OF SKIN AND / OR LIP
WO2006100154A1 (en) 2005-03-24 2006-09-28 Nolabs Ab Cosmetic treatment with nitric oxide, device for performing said treatment and manufacturing method therefor
EP1704876A1 (en) * 2005-03-24 2006-09-27 NOLabs AB Cosmetic treatment, device for performing said treatment and manufacturing method thereof
WO2006125123A2 (en) * 2005-05-19 2006-11-23 University Of Cincinnati Methods for treating bacterial respiratory tract infections in an individual using acidified nitrite
CA2606565C (en) 2005-05-27 2016-05-10 The University Of North Carolina At Chapel Hill Nitric oxide-releasing particles for nitric oxide therapeutics and biomedical applications
US8453044B2 (en) * 2005-06-29 2013-05-28 Within3, Inc. Collections of linked databases
SE529058C2 (en) 2005-07-08 2007-04-17 Plasma Surgical Invest Ltd Plasma generating device, plasma surgical device, use of a plasma surgical device and method for forming a plasma
SE529053C2 (en) 2005-07-08 2007-04-17 Plasma Surgical Invest Ltd Plasma generating device, plasma surgical device and use of a plasma surgical device
SE529056C2 (en) 2005-07-08 2007-04-17 Plasma Surgical Invest Ltd Plasma generating device, plasma surgical device and use of a plasma surgical device
US8190681B2 (en) * 2005-07-27 2012-05-29 Within3, Inc. Collections of linked databases and systems and methods for communicating about updates thereto
CA2619925A1 (en) 2005-09-07 2007-03-15 Tyco Healthcare Group Lp Wound dressing with vacuum reservoir
US10395326B2 (en) * 2005-11-15 2019-08-27 3Degrees Llc Collections of linked databases
US20070116785A1 (en) * 2005-11-18 2007-05-24 Miller Christopher C Nitric oxide as an anti-viral agent, vaccine and vaccine adjuvant
CN1990045B (en) * 2005-12-30 2010-12-22 北京尼奥克斯生物科技有限公司 Highly effective plaster for burn and scald and its preparation process
US8790715B2 (en) * 2006-02-16 2014-07-29 Ino Therapeutics Llc Method and apparatus for generating nitric oxide for medical use
GB0614278D0 (en) * 2006-07-19 2006-08-30 Insense Ltd Hydrogen peroxide delivery system
GB0618711D0 (en) * 2006-09-22 2006-11-01 Univ Exeter Agricultural treatment
US8079998B2 (en) * 2006-10-20 2011-12-20 Pulmonox Technologies Corporation Methods and devices for the delivery of therapeutic gases including nitric oxide
US20100143503A1 (en) * 2006-12-22 2010-06-10 Ikaria, Inc. Combinations of nitric oxide and sulfide and methods of use and manufacture thereof
US7928338B2 (en) 2007-02-02 2011-04-19 Plasma Surgical Investments Ltd. Plasma spraying device and method
US20080193385A1 (en) * 2007-02-08 2008-08-14 Todd Maibach Compositions and methods for treating neuropathy
US20080193566A1 (en) * 2007-02-09 2008-08-14 Miller Christopher C Use of high dose concentrations of gaseous nitric oxide
AU2008232413B2 (en) 2007-03-23 2013-09-19 VERO Biotech LLC. Conversion of nitrogen dioxide (NO2) to nitric oxide (NO)
BRPI0721507A2 (en) * 2007-03-27 2013-01-08 Nolabs Ab Typical Nitric Oxide Dispensing Device, Kit, Nitric Oxide Usage, and Typical Nitric Oxide Dispensing and Treatment Methods
US20100292280A1 (en) * 2007-04-15 2010-11-18 Oron Zachar Anti-pyretic vasodilators
WO2008134490A1 (en) * 2007-04-26 2008-11-06 2B Technologies, Inc Method to produce a calibration, reagent or therapeutic gas by exposing a precursor gas to ultraviolet light
US8735766B2 (en) 2007-08-06 2014-05-27 Plasma Surgical Investments Limited Cathode assembly and method for pulsed plasma generation
US7589473B2 (en) 2007-08-06 2009-09-15 Plasma Surgical Investments, Ltd. Pulsed plasma device and method for generating pulsed plasma
US9278157B2 (en) 2007-08-09 2016-03-08 Insense Limited Nitric oxide-generating skin dressings
GB0715556D0 (en) * 2007-08-09 2007-09-19 Insense Ltd Improvements relating to skin dressings
US20090130233A1 (en) * 2007-10-24 2009-05-21 Baker Christopher G Two part lotion
WO2009065142A2 (en) * 2007-11-15 2009-05-22 Biomedical Research Foundation Of Northwest Louisiana Use of nitrite salts in chronic ischemia
AU2008345034A1 (en) * 2007-12-27 2009-07-09 Aires Pharmaceuticals, Inc. Aerosolized nitrite and nitric oxide - donating compounds and uses thereof
WO2009093169A1 (en) * 2008-01-22 2009-07-30 Koninklijke Philips Electronics N.V. Device for the topical delivery of nitric oxide to a skin surface
US8986253B2 (en) 2008-01-25 2015-03-24 Tandem Diabetes Care, Inc. Two chamber pumps and related methods
EP2247381B1 (en) 2008-01-28 2016-11-30 Geno LLC Conversion of nitrogen dioxide (no2) to nitric oxide (no)
US8720436B2 (en) * 2008-01-31 2014-05-13 Genosys, Inc. Nitric oxide gel apparatus and method
US8303995B1 (en) * 2008-06-13 2012-11-06 Board Of Regents, The University Of Texas System Nitrite formulations and their use as nitric oxide prodrugs
US20110104240A1 (en) * 2008-06-24 2011-05-05 Micropharma Limited Nitric Oxide Device and Method for Wound Healing, Treatment of Dermatological Disorders and Microbial Infections
US8607785B2 (en) * 2008-08-21 2013-12-17 Geno Llc Systems and devices for generating nitric oxide
US8408421B2 (en) 2008-09-16 2013-04-02 Tandem Diabetes Care, Inc. Flow regulating stopcocks and related methods
AU2009293019A1 (en) 2008-09-19 2010-03-25 Tandem Diabetes Care Inc. Solute concentration measurement device and related methods
US20120237617A1 (en) 2009-06-18 2012-09-20 Theravasc Inc. Use of nitrite salts in treating tissue damage
AU2010263098B2 (en) 2009-06-22 2016-01-07 VERO Biotech LLC. Nitric oxide therapies
KR20160017133A (en) * 2009-06-24 2016-02-15 스트러티직 사이언스 앤드 테크놀로지스, 엘엘씨 Topical composition containing ibuprofen
US9072659B2 (en) 2009-06-24 2015-07-07 Strategic Science & Technologies, Llc Topical composition containing naproxen
US11684624B2 (en) 2009-06-24 2023-06-27 Strategic Science & Technologies, Llc Treatment of erectile dysfunction and other indications
CA2769030C (en) 2009-07-30 2016-05-10 Tandem Diabetes Care, Inc. Infusion pump system with disposable cartridge having pressure venting and pressure feedback
CN102695528B (en) 2009-08-21 2016-07-13 诺万公司 Wound dressing, its using method and forming method thereof
ES2958410T3 (en) 2009-08-21 2024-02-08 Novan Inc Topical gels
AU2010321707B2 (en) * 2009-11-20 2016-03-17 VERO Biotech LLC. Nitric oxide delivery system
US8613742B2 (en) 2010-01-29 2013-12-24 Plasma Surgical Investments Limited Methods of sealing vessels using plasma
US9089319B2 (en) 2010-07-22 2015-07-28 Plasma Surgical Investments Limited Volumetrically oscillating plasma flows
US20120107423A1 (en) 2010-11-01 2012-05-03 Ino Therapeutics Llc Methods of Using Inhaled Nitric Oxide Gas for Treatment of Acute Respiratory Distress Syndrome
US8591876B2 (en) 2010-12-15 2013-11-26 Novan, Inc. Methods of decreasing sebum production in the skin
CN105878172A (en) 2010-12-29 2016-08-24 战略科学与技术有限责任公司 Systems and methods for treatment of allergies and other indications
JP2014504592A (en) 2010-12-29 2014-02-24 ストラテジック サイエンス アンド テクノロジーズ， エルエルシー Treatment of erectile dysfunction and other indications
WO2012118819A2 (en) 2011-02-28 2012-09-07 Novan, Inc. Nitric oxide-releasing s-nitrosothiol-modified silica particles and methods of making the same
CA2830298C (en) 2011-03-17 2016-08-16 Transdermal Biotechnology, Inc. Topical nitric oxide systems comprising lecithin and methods of use thereof
WO2012131412A2 (en) 2011-03-31 2012-10-04 Szabo Laszlo Gabor Pharmaceutical composition containing no, process for the preparation and use thereof
ES2804263T3 (en) 2011-07-05 2021-02-05 Novan Inc Topical compositions
WO2013006613A1 (en) 2011-07-05 2013-01-10 Novan, Inc. Methods of manufacturing topical compositions and apparatus for same
TW201330871A (en) * 2011-12-05 2013-08-01 Nioxx Taiwan Biotechnology Inc Compositions and methods for topical nitric oxide generation
US9180242B2 (en) 2012-05-17 2015-11-10 Tandem Diabetes Care, Inc. Methods and devices for multiple fluid transfer
CN104603097A (en) 2012-05-23 2015-05-06 塞利克斯比奥私人有限公司 Compositions and methods for the treatment of multiple sclerosis
WO2013175357A2 (en) 2012-05-23 2013-11-28 Mahesh Kandula Compositions and methods for the treatment of inflammatory bowel disease
US9555186B2 (en) 2012-06-05 2017-01-31 Tandem Diabetes Care, Inc. Infusion pump system with disposable cartridge having pressure venting and pressure feedback
CN103690490B (en) * 2012-08-23 2017-11-17 尼奥克斯(文莱)控股有限公司 Nitric oxide production system and method are produced based on microencapsulated chemical agent delay
US20140065090A1 (en) * 2012-08-31 2014-03-06 W. L. Gore & Associates, Inc. Reactive Oxidative Species Generating Materials and Methods of Use
US9259435B2 (en) 2012-08-31 2016-02-16 W. L. Gore & Associates, Inc. Reactive oxidative species generating materials and methods of use
US8871259B2 (en) 2012-09-19 2014-10-28 Transdermal Biotechnology, Inc. Techniques and systems for treatment of neuropathic pain and other indications
US8871261B2 (en) 2012-09-19 2014-10-28 Transdermal Biotechnology, Inc. Cancer treatments and compositions for use thereof
US8871258B2 (en) * 2012-09-19 2014-10-28 Transdermal Biotechnology, Inc. Treatment and prevention of learning and memory disorders
US8871257B2 (en) 2012-09-19 2014-10-28 Transdermal Biotechnology, Inc. Prevention and treatment of cardiovascular diseases using systems and methods for transdermal nitric oxide delivery
US8871254B2 (en) 2012-09-19 2014-10-28 Transdermal Biotechnology, Inc. Systems and methods for treatment of acne vulgaris and other conditions with a topical nitric oxide delivery system
US8871255B2 (en) 2012-09-19 2014-10-28 Transdermal Biotechnology, Inc. Treatment of skin and soft tissue infection with nitric oxide
US8871262B2 (en) 2012-09-19 2014-10-28 Transdermal Biotechnology, Inc. Compositions and methods for treatment of osteoporosis and other indications
US8871260B2 (en) 2012-09-19 2014-10-28 Transdermal Biotechnology, Inc. Methods and compositions for muscular and neuromuscular diseases
US8871256B2 (en) 2012-09-19 2014-10-28 Transdermal Biotechnology, Inc. Methods and systems for treatment of inflammatory diseases with nitric oxide
US9855211B2 (en) * 2013-02-28 2018-01-02 Novan, Inc. Topical compositions and methods of using the same
US9314423B2 (en) 2013-03-13 2016-04-19 Transdermal Biotechnology, Inc. Hair treatment systems and methods using peptides and other compositions
US9393264B2 (en) 2013-03-13 2016-07-19 Transdermal Biotechnology, Inc. Immune modulation using peptides and other compositions
US9687520B2 (en) 2013-03-13 2017-06-27 Transdermal Biotechnology, Inc. Memory or learning improvement using peptide and other compositions
US9387159B2 (en) 2013-03-13 2016-07-12 Transdermal Biotechnology, Inc. Treatment of skin, including aging skin, to improve appearance
US9724419B2 (en) * 2013-03-13 2017-08-08 Transdermal Biotechnology, Inc. Peptide systems and methods for metabolic conditions
US9314417B2 (en) 2013-03-13 2016-04-19 Transdermal Biotechnology, Inc. Treatment of skin, including aging skin, to improve appearance
US9320706B2 (en) 2013-03-13 2016-04-26 Transdermal Biotechnology, Inc. Immune modulation using peptides and other compositions
US9295647B2 (en) 2013-03-13 2016-03-29 Transdermal Biotechnology, Inc. Systems and methods for delivery of peptides
US9750787B2 (en) * 2013-03-13 2017-09-05 Transdermal Biotechnology, Inc. Memory or learning improvement using peptide and other compositions
US20140271937A1 (en) 2013-03-13 2014-09-18 Transdermal Biotechnology, Inc. Brain and neural treatments comprising peptides and other compositions
US9393265B2 (en) 2013-03-13 2016-07-19 Transdermal Biotechnology, Inc. Wound healing using topical systems and methods
US9314422B2 (en) * 2013-03-13 2016-04-19 Transdermal Biotechnology, Inc. Peptide systems and methods for metabolic conditions
US9314433B2 (en) 2013-03-13 2016-04-19 Transdermal Biotechnology, Inc. Methods and systems for treating or preventing cancer
US20140271938A1 (en) 2013-03-13 2014-09-18 Transdermal Biotechnology, Inc. Systems and methods for delivery of peptides
US9295637B2 (en) 2013-03-13 2016-03-29 Transdermal Biotechnology, Inc. Compositions and methods for affecting mood states
US9339457B2 (en) 2013-03-13 2016-05-17 Transdermal Biotechnology, Inc. Cardiovascular disease treatment and prevention
US20140271731A1 (en) 2013-03-13 2014-09-18 Transdermal Biotechnology, Inc. Cardiovascular disease treatment and prevention
US9295636B2 (en) 2013-03-13 2016-03-29 Transdermal Biotechnology, Inc. Wound healing using topical systems and methods
US9320758B2 (en) 2013-03-13 2016-04-26 Transdermal Biotechnology, Inc. Brain and neural treatments comprising peptides and other compositions
US9241899B2 (en) 2013-03-13 2016-01-26 Transdermal Biotechnology, Inc. Topical systems and methods for treating sexual dysfunction
US9849160B2 (en) 2013-03-13 2017-12-26 Transdermal Biotechnology, Inc. Methods and systems for treating or preventing cancer
US9173998B2 (en) 2013-03-14 2015-11-03 Tandem Diabetes Care, Inc. System and method for detecting occlusions in an infusion pump
US10517817B2 (en) 2013-05-09 2019-12-31 Syk Technologies, Llc Deep topical systemic nitric oxide therapy apparatus and method
BR112016002387B1 (en) 2013-08-08 2019-05-21 Novan, Inc. Topical Pharmaceutical Compositions, and Method for Storage
JP2017503801A (en) 2014-01-10 2017-02-02 イノ セラピューティックス エルエルシー How to use inhaled nitric oxide gas for the treatment of acute respiratory distress syndrome in children
US10322082B2 (en) 2014-07-11 2019-06-18 Novan, Inc. Topical antiviral compositions and methods of using the same
CN106659675B (en) 2014-07-11 2023-07-04 诺万公司 Topical antiviral compositions and methods of use thereof
CA2919733A1 (en) 2014-08-08 2016-02-08 Novan, Inc. Topical compositions and methods of using the same
WO2016027163A1 (en) * 2014-08-18 2016-02-25 Bovicor Pharmatech Inc. Nitric oxide treatment of mammary tissue
SG11201706952VA (en) 2014-09-26 2017-10-30 Cellix Bio Private Ltd Compositions and methods for the treatment of epilepsy and neurological disorders
CA2967908C (en) 2014-09-29 2020-11-17 Mahesh Kandula Compositions and methods for the treatment of multiple sclerosis
WO2016067297A1 (en) 2014-10-27 2016-05-06 Cellix Bio Private Limited Salts of valproic acid with piperazine, ethylenediamine, lysine and/or eicosapentaenoic ecid (epa) amine derivatives for the treatment of epilepsy
WO2016098119A1 (en) 2014-10-27 2016-06-23 Cellix Bio Private Limited Three component salts of fumaric acid monomethyl ester with piperazine or ethylene diamine for the treatment of multiple sclerosis
EP3217960B1 (en) * 2014-11-10 2020-01-08 The United States of America, as represented by The Secretary, Department of Health and Human Services Topical sodium nitrite formulation
WO2016088132A1 (en) 2014-12-01 2016-06-09 Cellix Bio Private Limited Compositions and methods for the treatment of multiple sclerosis
SG10201906474QA (en) 2015-02-09 2019-09-27 Cellix Bio Private Ltd Compositions and methods for the treatment of mucositis
ITUB20154719A1 (en) 2015-10-21 2017-04-21 Glano Tech Ltd FORMULATION FOR THE RELEASE OF NITRIC OXIDE
US10052348B2 (en) 2016-01-27 2018-08-21 Syk Technologies, Llc Nitric oxide topical application apparatus and methods
EP3423100A4 (en) 2016-03-02 2019-10-16 Novan, Inc. Compositions for treating inflammation and methods of treating the same
CN109310630A (en) 2016-04-13 2019-02-05 诺万公司 For treating composition, system, kit and the method for infection
US11173235B2 (en) 2016-07-15 2021-11-16 Cook Regentec Llc Nitrite eluting devices and methods of use thereof
WO2018029545A1 (en) 2016-08-11 2018-02-15 Cellix Bio Private Limited Compositions and methods for the treatment of irritable bowel syndrome
AU2017339726B2 (en) 2016-10-04 2022-07-14 Cellix Bio Private Limited Compositions and methods for the treatment of xerostomia
WO2018115984A1 (en) 2016-12-19 2018-06-28 Cellix Bio Private Limited Compositions and methods for the treatment of inflammation
ES2965705T3 (en) * 2017-02-09 2024-04-16 Noxsano Inc Electrochemical gasotransmitter generating compositions and methods of using them, and dressings and treatment systems that incorporate them
CA3070805A1 (en) 2017-07-27 2019-01-31 Allergan, Inc. Prostacyclin receptor agonists for reduction of body fat
CN108096296B (en) * 2017-10-11 2020-10-16 河北京鼎生物医药科技有限公司 System and article for prolonged nitric oxide production based on microencapsulated powders and acidic gels of spinach extracts
CN108096297B (en) * 2017-10-11 2020-12-18 河北京鼎生物医药科技有限公司 Prolonged nitric oxide release system and kit comprising a microencapsulated spinach extract and an acidic microencapsulated powder
KR102003876B1 (en) * 2017-11-01 2019-10-04 경희대학교 산학협력단 A water-in-oil type emulsion composition for improving impotence
RU2761436C1 (en) 2017-11-17 2021-12-08 Целликс Био Прайвет Лимитед Compositions and methods for treating visual organ disorders
CN111315369A (en) 2017-11-17 2020-06-19 塞尔利克斯生物私人有限公司 Compounds, compositions and methods for treating ocular disorders and skin diseases
TW201927292A (en) 2017-12-13 2019-07-16 大陸商上海小午醫藥科技有限公司 A method for preventing or treating a disease associated with inhibition of EGFR
US11472705B2 (en) 2018-03-13 2022-10-18 Sanotize Research And Development Corp. Nitric oxide releasing compositions
US10716805B2 (en) * 2018-03-19 2020-07-21 Glanotech Limited Formulation for release of nitric oxide
TW201943428A (en) 2018-04-16 2019-11-16 大陸商上海岸闊醫藥科技有限公司 Method for preventing or treating side effects of cancer therapy
WO2020227367A1 (en) * 2019-05-06 2020-11-12 Pneuma Nitric Oxide, Llc Nitric oxide compositions and topical uses thereof
AU2020286677A1 (en) 2019-06-04 2021-12-09 Thirty Holdings Limited Methods and compositions for generating nitric oxide and uses thereof
CA3142109A1 (en) 2019-06-04 2020-12-10 Thirty Respiratory Limited Methods and compositions for generating nitric oxide and uses thereof to deliver nitric oxide via the respiratory tract
JP2022550990A (en) 2019-10-07 2022-12-06 インセンス・リミテッド Compositions that deliver nitric oxide to the skin
WO2021214440A1 (en) 2020-04-23 2021-10-28 Thirty Respiratory Limited Nitric oxide or nitric oxide releasing compositions for use in treating sars-cov and sars-cov-2
WO2021214439A1 (en) 2020-04-23 2021-10-28 Thirty Respiratory Limited Methods and compositions for treating and combatting tuberculosis
IL300972A (en) 2020-08-28 2023-04-01 Plasma Surgical Invest Ltd Systems, methods, and devices for generating predominantly radially expanded plasma flow

Family Cites Families (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2054661A1 (en) * 1970-11-06 1972-05-10 Badische Anilin & Soda Fabrik AG, 6700 Ludwigshafen N-nitrosa-n-aryl-hydroxylamines prepn - from nitrosa-arenes and nitrogen oxide
GB1322812A (en) * 1971-02-04 1973-07-11 Ilford Ltd Photographic materials
US4535154A (en) * 1981-07-13 1985-08-13 United States Of America Reductive destruction of nitrosamines, hydrazines, nitramines, azo- and azoxy-compounds
US4954526A (en) * 1989-02-28 1990-09-04 The United States Of America As Represented By The Department Of Health And Human Services Stabilized nitric oxide - primary amine complexes useful as cardiovascular agents
US5039705A (en) * 1989-09-15 1991-08-13 The United States Of America As Represented By The Department Of Health And Human Services Anti-hypertensive compositions of secondary amine-nitric oxide adducts and use thereof
US5208233A (en) * 1989-09-15 1993-05-04 The United States Of America As Represented By The Department Of Health And Human Services Anti-hypertensive compositions of secondary amine-nitric oxide adducts and use thereof
US5212204A (en) * 1989-10-18 1993-05-18 The United States Of America As Represented By The Department Of Health And Human Services Antihypertensive compositions and use thereof
US5155137A (en) * 1990-09-20 1992-10-13 The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Complexes of nitric oxide with polyamines
US5683668A (en) * 1990-09-20 1997-11-04 The United States Of America As Represented By The Department Of Health And Human Services Method of generating nitric oxide gas using nitric oxide complexes
US5185376A (en) * 1991-09-24 1993-02-09 The United States Of America As Represented By The Department Of Health And Human Services Therapeutic inhibition of platelet aggregation by nucleophile-nitric oxide complexes and derivatives thereof
WO1994018954A1 (en) * 1993-02-22 1994-09-01 Vivorx Pharmaceuticals, Inc. Methods for in vivo delivery of biologics and compositions useful therefor
US5840759A (en) * 1993-10-08 1998-11-24 The United States Of America As Represented By The Department Of Health And Human Services Use of nitric oxide releasing compounds to protect noncancerous cells from chemotherapeutic agents
EP0726768B1 (en) * 1993-11-02 2000-05-17 THE UNITED STATES OF AMERICA, represented by THE SECRETARY, Department of Health and Human Services Use of nitric oxide releasing compounds for the manufacture of a medicament for protection in ischemia reperfusion injury
US5519020A (en) * 1994-10-28 1996-05-21 The University Of Akron Polymeric wound healing accelerators
US5648101A (en) * 1994-11-14 1997-07-15 Tawashi; Rashad Drug delivery of nitric oxide
US5698738A (en) * 1995-05-15 1997-12-16 Board Of Regents, The University Of Texas System N-nitroso-N-substituted hydroxylamines as nitric oxide donors
US5726209A (en) * 1995-06-07 1998-03-10 Alliance Pharmaceutical Corp. Liquid fluorocarbon emulsion as a vascular nitric oxide reservoir
SE9700617D0 (en) * 1997-02-21 1997-02-21 Kjell Alving New composition
US5888528A (en) * 1997-05-19 1999-03-30 Bernard Technologies, Inc. Sustained release biocidal powders
US6103275A (en) * 1998-06-10 2000-08-15 Nitric Oxide Solutions Systems and methods for topical treatment with nitric oxide

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2011085484A1 (en) * 2010-01-13 2011-07-21 Nitric Solutions Inc. Antimicrobial nitric oxide compositions

Also Published As

Publication number Publication date
DE60042174D1 (en) 2009-06-18
ATE430584T1 (en) 2009-05-15
EP1283724A1 (en) 2003-02-19
US7048951B1 (en) 2006-05-23
CA2410990C (en) 2011-08-02
EP1283724B1 (en) 2009-05-06
AU2000250426A1 (en) 2002-02-21
WO2001089572A1 (en) 2001-11-29
AU2000250426B2 (en) 2005-06-30
US6103275A (en) 2000-08-15
AU5042600A (en) 2001-12-03

Similar Documents

Publication Publication Date Title
CA2410990A1 (en) Systems and methods for topical treatment with nitric oxide
US5525356A (en) Amphoteric N-substituted acrylamide hydrogel and method
DE3222800C2 (en)
US4917895A (en) Transdermal drug delivery device
US4230105A (en) Transdermal delivery of drugs
CA2706828C (en) Skin dressings generating nitric oxide to improve healing
CA2135925A1 (en) Use of glycerin in moderating transdermal drug delivery
EP2533773B1 (en) Topical dermal delivery device for nitric oxide delivery
US20090074880A1 (en) Method for oxygen treatment of intact skin
EP0679390A3 (en) Sprayable topical pharmaceutical compositions
JP4316177B2 (en) Exothermic local feeder
AU4261097A (en) Compositions and methods for topical application of therapeutic agents
EP0857488A3 (en) Methods and compositions for enhancing skin permeation of drugs using permeation enhancers
EP0857488A1 (en) Methods and compositions for enhancing skin permeation of drugs using permeation enhancers
CA2554191A1 (en) Improvements in or relating to skin dressings
CA2326662A1 (en) Therapeutic system which can be moisture-activated
US9044462B2 (en) Method for oxygen treatment of intact skin
US20150030702A1 (en) Nitric oxide-generating skin dressings
CA2750758A1 (en) Treatment of psoriasis
US20010019722A1 (en) Anti-acne chrono patch
US20090217924A1 (en) Treatment systems and methods
US5348981A (en) Antiherpetic treatment
Raab Combined Use of Imidazole Derivatives and Glucocorticoids for the Local Treatment of Skin Disease
JP2004067656A (en) Constitution of liquid agent for pack mainly composed of vitamin c

Legal Events

Date Code Title Description
EEER Examination request
MKLA Lapsed

Effective date: 20180524