CA2407115A1 - Calcium phosphate cements prepared from silicate solutions - Google Patents

Calcium phosphate cements prepared from silicate solutions Download PDF

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Publication number
CA2407115A1
CA2407115A1 CA002407115A CA2407115A CA2407115A1 CA 2407115 A1 CA2407115 A1 CA 2407115A1 CA 002407115 A CA002407115 A CA 002407115A CA 2407115 A CA2407115 A CA 2407115A CA 2407115 A1 CA2407115 A1 CA 2407115A1
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CA
Canada
Prior art keywords
calcium phosphate
composition
solution
containing product
calcium
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA002407115A
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French (fr)
Other versions
CA2407115C (en
Inventor
Brent R. Constantz
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Skeletal Kinetics LLC
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Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2407115A1 publication Critical patent/CA2407115A1/en
Application granted granted Critical
Publication of CA2407115C publication Critical patent/CA2407115C/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
    • A61L24/02—Surgical adhesives or cements; Adhesives for colostomy devices containing inorganic materials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K6/00—Preparations for dentistry
    • A61K6/80—Preparations for artificial teeth, for filling teeth or for capping teeth
    • A61K6/849—Preparations for artificial teeth, for filling teeth or for capping teeth comprising inorganic cements
    • A61K6/853—Silicates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K6/00—Preparations for dentistry
    • A61K6/80—Preparations for artificial teeth, for filling teeth or for capping teeth
    • A61K6/849—Preparations for artificial teeth, for filling teeth or for capping teeth comprising inorganic cements
    • A61K6/864—Phosphate cements
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K6/00—Preparations for dentistry
    • A61K6/80—Preparations for artificial teeth, for filling teeth or for capping teeth
    • A61K6/884—Preparations for artificial teeth, for filling teeth or for capping teeth comprising natural or synthetic resins
    • A61K6/898—Polysaccharides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/02—Inorganic materials
    • A61L27/12—Phosphorus-containing materials, e.g. apatite

Abstract

Methods are provided for producing flowable compositions, e.g. pastes, that set into calcium phosphate products. In the subject methods, dry reactants that include a calcium source and a phosphate source are combined with a solution of a soluble silicate, e.g. sodium silicate, and the combined liquids and solids are mixed to produce the flowable composition. Also provided are the compositions themselves as well as kits for preparing the same. The subject methods and compositions produced thereby find use in a variety of applications, including the repair of hard tissue defects, e.g. bone defects.

Claims (30)

WHAT IS CLAIMED IS:
1. A method of producing a flowable composition that sets into a calcium phosphate containing product, said method comprising:
combining:
(a) a silicate solution; and (b) dry reactants comprising a calcium source and a phosphate source, wherein said silicate solution and dry reactants are combined in a ratio sufficient to produce a flowable material;
whereby a flowable material that sets into a calcium phosphate containing product is produced.
2. The method according to Claim 1, wherein said ratio ranges from about 0.2:1 to 0.7:1.
3. The method according to Claim 2, wherein said flowable composition is a paste.
4. The method according to Claim 1, wherein said silicate solution is a solution of a soluble silicate having a concentration ranging from about 1% to 15%.
5. The method according to Claim 1, wherein said flowable composition sets into said calcium phosphate containing product in a period of time ranging from about 5 to 10 minutes.
6. The method according to Claim 1, wherein said calcium phosphate containing product has a compressive strength ranging from about 25 to 100 MPa.
7. A method of producing a paste that sets into a calcium phosphate containing product, said method comprising:
(a) combining:
(i) dry reactants comprising a calcium source and a phosphate source;
and (ii) a solution of a soluble silicate having a concentration ranging from about 5% to 10%, wherein said dry reactants and said solution are combined in a ratio sufficient to provide for said paste; and (b) mixing said combined reactants and solution for a sufficient period of time to produce a paste;
whereby a paste capable of setting into a calcium phosphate containing product is produced.
8. The method according to Claim 7, wherein said ratio ranges from about 0.3 to 0.5.
9. The method according to Claim 7, wherein said paste sets in a period of time ranging from about 4 to 10 minutes into a calcium phosphate containing product having a compressive strength ranging from about 40 to 70 MPa.
10. The method according to Claim 7, wherein said soluble silicate is sodium silicate.
11. A flowable composition that sets into a calcium phosphate containing product, wherein said composition is produced by the method comprising:
combining dry reactants comprising a source of calcium and phosphate with a solution of a soluble silicate; and mixing said combined dry reactants and solution for a period of time sufficient to produce said flowable product.
12. The composition according to Claim 11, wherein said composition is a paste.
13. The composition according to Claim 11, wherein said calcium phosphate containing product is an apatitic product.
14. The composition according to Claim 11, wherein said composition sets in period of time ranging from about 4 to 12 minutes.
15. The composition according to Claim 11, wherein said calcium phosphate containing product has a compressive strength ranging from about 25 to 100.
16. A kit for use in a preparing a flowable composition that sets into a calcium phosphate product, said kit comprising:
(a) dry reactants comprising a calcium source and a phosphate source; and (b) a solution of a soluble silicate.
17. The kit according to Claim 16, wherein said soluble silicate has a concentration ranging from about 5 to 10%.
1 S. The kit according to Claim 16, wherein said soluble silicate is a sodium silicate.
19. A method of repairing a hard tissue defect, said method comprising:
applying to the site of said defect a flowable composition that sets into a calcium phosphate containing product, wherein said composition is produced by the method comprising:
(a) combining dry reactants comprising a source of calcium and phosphate with a solution of a soluble silicate; and (b) mixing said combined dry reactants and solution for a period of time sufficient to produce said flowable product.
20. The method according to Claim 19, wherein said composition is a paste.
21. The method according to Claim 19, wherein said calcium phosphate containing product is an apatitic product.
22. The method according to Claim 19, wherein said composition sets in period of time ranging from about 4 to 12 minutes.
23. The method according to Claim 19, wherein said calcium phosphate containing product has a compressive strength ranging from about 25 to 100 MPa.
24. The method according to Claim 19, wherein said hard tissue is bone.
25. The method according to Claim 24, wherein said defect is a reduced fracture.
26. The method according to Claim 24, wherein said defect is a defect in the cranium.
27. A packaged calcium phosphate cement, said packaged cement comprising:
a tubular element separated into first and second compartments by a removable barrier;
dry reactants comprising a source of calcium and phosphate present in said first compartment; and a solution of a soluble silicate present in said second compartment.
28. The packaged calcium phosphate cement according to Claim 27, wherein said removable barrier is a clip.
29. The packaged calcium phosphate cement according to claim 27, wherein said removable barrier is a frangible barrier.
30. The packaged calcium phosphate cement according to Claim 27, wherein said tubular element is present inside a second sterility maintaining element.
CA2407115A 2000-04-28 2001-04-27 Calcium phosphate cements prepared from silicate solutions Expired - Lifetime CA2407115C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US09/561,324 US6375935B1 (en) 2000-04-28 2000-04-28 Calcium phosphate cements prepared from silicate solutions
US09/561,324 2000-04-28
PCT/US2001/013853 WO2001082834A1 (en) 2000-04-28 2001-04-27 Calcium phosphate cements prepared from silicate solutions

Publications (2)

Publication Number Publication Date
CA2407115A1 true CA2407115A1 (en) 2001-11-08
CA2407115C CA2407115C (en) 2010-02-09

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
CA2407115A Expired - Lifetime CA2407115C (en) 2000-04-28 2001-04-27 Calcium phosphate cements prepared from silicate solutions

Country Status (9)

Country Link
US (2) US6375935B1 (en)
EP (1) EP1284680B1 (en)
JP (1) JP4996030B2 (en)
AT (1) ATE408384T1 (en)
AU (2) AU2001259251B2 (en)
CA (1) CA2407115C (en)
DE (1) DE60135841D1 (en)
ES (1) ES2313958T3 (en)
WO (1) WO2001082834A1 (en)

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Also Published As

Publication number Publication date
ATE408384T1 (en) 2008-10-15
US20020098245A1 (en) 2002-07-25
CA2407115C (en) 2010-02-09
US6375935B1 (en) 2002-04-23
EP1284680A1 (en) 2003-02-26
EP1284680A4 (en) 2005-04-20
ES2313958T3 (en) 2009-03-16
DE60135841D1 (en) 2008-10-30
US6719993B2 (en) 2004-04-13
EP1284680B1 (en) 2008-09-17
JP4996030B2 (en) 2012-08-08
AU5925101A (en) 2001-11-12
WO2001082834A1 (en) 2001-11-08
JP2003531798A (en) 2003-10-28
AU2001259251B2 (en) 2005-07-28

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