CA2406064A1 - Minimizing adverse experience associated with oxybutynin therapy - Google Patents

Minimizing adverse experience associated with oxybutynin therapy Download PDF

Info

Publication number
CA2406064A1
CA2406064A1 CA002406064A CA2406064A CA2406064A1 CA 2406064 A1 CA2406064 A1 CA 2406064A1 CA 002406064 A CA002406064 A CA 002406064A CA 2406064 A CA2406064 A CA 2406064A CA 2406064 A1 CA2406064 A1 CA 2406064A1
Authority
CA
Canada
Prior art keywords
composition
oxybutynin
desethyloxybutynin
metabolite
auc
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA002406064A
Other languages
French (fr)
Other versions
CA2406064C (en
Inventor
Steven W. Sanders
Charles D. Ebert
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Allergan Sales LLC
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=24234699&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CA2406064(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Individual filed Critical Individual
Publication of CA2406064A1 publication Critical patent/CA2406064A1/en
Application granted granted Critical
Publication of CA2406064C publication Critical patent/CA2406064C/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0019Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A61K9/0024Solid, semi-solid or solidifying implants, which are implanted or injected in body tissue
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/21Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/216Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acids having aromatic rings, e.g. benactizyne, clofibrate
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/14Esters of carboxylic acids, e.g. fatty acid monoglycerides, medium-chain triglycerides, parabens or PEG fatty acid esters
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0014Skin, i.e. galenical aspects of topical compositions
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0019Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/70Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A61K9/7023Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
    • A61K9/703Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
    • A61K9/7038Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer
    • A61K9/7046Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds
    • A61K9/7053Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds obtained by reactions only involving carbon to carbon unsaturated bonds, e.g. polyvinyl, polyisobutylene, polystyrene
    • A61K9/7061Polyacrylates
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00Drugs for disorders of the urinary system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00Drugs for disorders of the urinary system
    • A61P13/02Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00Drugs for disorders of the urinary system
    • A61P13/10Drugs for disorders of the urinary system of the bladder
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/02Drugs for disorders of the nervous system for peripheral neuropathies
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A61K47/38Cellulose; Derivatives thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/14Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605Excipients; Inactive ingredients
    • A61K9/1629Organic macromolecular compounds
    • A61K9/1641Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poloxamers
    • A61K9/1647Polyesters, e.g. poly(lactide-co-glycolide)

Abstract

The present invention provides compositions and methods for administering oxybutynin while minimizing the in-cidence and or severity of adverse drug experiences associated with oxybutynin therapy. In one aspect, these compositions and methods provide a lower plasma concentration of oxybutynin metabolites, such as N-desethyloxybutynin, which is presumed to be contributing at least in part to some of the adverse drug experiences, while maintaining sufficient oxybutynin plasma concentration to benefit a subject with oxybutynin therapy. The invention also provides isomers of oxybutynin and its metabolites that meet these characteristics of minimized incidence and/or severity of adverse drug experiences, and maintenance of beneficial and effective ther-apy for overactive bladder.

Claims (23)

1. A pharmaceutical composition that minimizes an adverse drug experience associated with oxybutynin therapy comprising: oxybutynin, wherein the composition provides a plasma area under the curve (AUC) ratio of oxybutynin to an oxybutynin metabolite of about 0.5:1 to about 5:1.
2. The composition of claim 1, wherein the AUC ratio of oxybutynin to an oxybutynin metabolite is about 0.5:1 to about 2:1.
3. The composition of claim 1, wherein the AUC ratio of oxybutynin to an oxybutynin metabolite is from about 1:1 to about 5:1.
4. The composition of claim l, wherein the AUC ratio of oxybutynin to an oxybutynin metabolite is from about 0.8:1 to about 1.5:1.
5. The composition of claim 1, wherein the oxybutynin in the plasma is (R)-oxybutynin, (S)-oxybutynin, or a combination thereof.
6. The composition of claim 1, wherein the metabolite of oxybutynin is N-desethyloxybutynin.
7. The composition of claim 6, wherein the N-desethyloxybutynin is (R)-N-desethyloxybutynin, (S)-N-desethyloxybutynin, or a combination thereof.
8. The composition of claim 5, wherein the AUC of (R)-oxybutynin to (S)-oxybutynin is about 0.7:1.
9. The composition of claim 7, wherein the AUC of (R)-N-desethyloxybutynin to (R)-oxybutynin is from about 0.4:1 to about 1.6:1.
10. The composition of claim 9, wherein the AUC ratio of (R)-N-desethyloxybutynin to (R)-oxybutynin is about 1:1.
11. The composition of claim 7, wherein the AUC ratio of (R)-N-desethyloxybutynin to (S)-N-desethyloxybutynin about 0.5:1 to about 1.3:1.
12. The composition of claim 7, wherein the AUC ratio of (R)-N-desethyloxybutynin to (S)-N-desethyloxybutynin is about 0.9:1.
13. The composition of claim 1, wherein the metabolite plasma concentration reaches a peak plasma value of less than about 8 ng/ml.
14. The composition of claim 1, wherein the metabolite plasma concentration reaches a peak value of less than about 5 ng/ml.
15. The composition of claim l, wherein the composition is a formulation which is selected from the group consisting of an oral, parenteral, transdermal, inhalant, or implantable composition.
16. The composition of claim 1, wherein the composition is a non-oral composition.
17. The composition of claim l, which is a sustained release composition.
18. The composition of claim 15, wherein the composition is a transdermal composition.
19. The composition of claim 18, further comprising an optional ingredient selected from the group consisting of: a permeation enhancer, an anti-irritant, an adhesion adjuster, or a combination thereof.
20. The method of claim 1, wherein the adverse drug experience is an experience selected from the group consisting of:
gastrointestinal/genitourinary, nervous system, cardiovascular, dermatological, and ophthalmic experiences, or a combination thereof.
21. The method of claim 20, wherein the adverse experience is an anticholinergic adverse experience, or an antimuscarinic adverse experience.
22. An article of manufacture for transdermal application comprising:
a composition as recited in any preceding claim wherein the composition provides, upon administration to a subject, a plasma AUC ratio of oxybutynin to an oxybutynin metabolite as recited in any preceding claim.
23. A method of minimizing an adverse drug experience associated with oxybutynin therapy comprising the step of:
administering a pharmaceutical composition as in any of claims 1-21.
CA2406064A 2000-04-26 2001-04-24 Minimizing adverse experience associated with oxybutynin therapy Expired - Lifetime CA2406064C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US55971100A 2000-04-26 2000-04-26
US09/559,711 2000-04-26
PCT/US2001/013135 WO2001080796A1 (en) 2000-04-26 2001-04-24 Minimizing adverse experience associated with oxybutynin therapy

Publications (2)

Publication Number Publication Date
CA2406064A1 true CA2406064A1 (en) 2001-11-01
CA2406064C CA2406064C (en) 2011-03-15

Family

ID=24234699

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2406064A Expired - Lifetime CA2406064C (en) 2000-04-26 2001-04-24 Minimizing adverse experience associated with oxybutynin therapy

Country Status (16)

Country Link
US (6) US6743441B2 (en)
EP (3) EP1992342A1 (en)
JP (3) JP2003531157A (en)
CN (4) CN101305994A (en)
AT (1) ATE488233T1 (en)
AU (2) AU2001253782B2 (en)
BR (1) BR0110381A (en)
CA (1) CA2406064C (en)
CY (1) CY1111498T1 (en)
DE (1) DE60143477D1 (en)
DK (1) DK1280486T3 (en)
ES (1) ES2357699T3 (en)
HK (1) HK1052287A1 (en)
MX (2) MX342305B (en)
PT (1) PT1280486E (en)
WO (1) WO2001080796A1 (en)

Families Citing this family (33)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AR018321A1 (en) * 1998-03-26 2001-11-14 Alza Corp A DOSAGE FORM OF PROLONGED LIBERATION THAT INCLUDES OXIBUTININE AND THE USES OF OXIBUTININE AND THE DOSAGE FORM OF PROLONGED LIBERATION.
US7029694B2 (en) 2000-04-26 2006-04-18 Watson Laboratories, Inc. Compositions and methods for transdermal oxybutynin therapy
US7179483B2 (en) * 2000-04-26 2007-02-20 Watson Pharmaceuticals, Inc. Compositions and methods for transdermal oxybutynin therapy
EP1992342A1 (en) * 2000-04-26 2008-11-19 Watson Pharmaceuticals, Inc. Minimizing adverse experience associated with oxybutynin therapy
US7198801B2 (en) * 2000-08-03 2007-04-03 Antares Pharma Ipl Ag Formulations for transdermal or transmucosal application
US20070225379A1 (en) * 2001-08-03 2007-09-27 Carrara Dario Norberto R Transdermal delivery of systemically active central nervous system drugs
US8980290B2 (en) 2000-08-03 2015-03-17 Antares Pharma Ipl Ag Transdermal compositions for anticholinergic agents
AU8206401A (en) * 2000-08-03 2002-02-18 Antares Pharma Ipl Ag Novel composition for transdermal and/or transmucosal administration of active compounds that ensures adequate therapeutic levels
US20040198706A1 (en) * 2003-03-11 2004-10-07 Carrara Dario Norberto R. Methods and formulations for transdermal or transmucosal application of active agents
US8226972B2 (en) * 2001-12-20 2012-07-24 Femmepharma Holding Company, Inc. Vaginal delivery of drugs
JP4354678B2 (en) * 2002-08-28 2009-10-28 久光製薬株式会社 Patch
AU2012216593B2 (en) * 2002-11-01 2014-09-25 Allergan Sales, Llc Compositions and methods for transdermal oxybutynin therapy
US9173836B2 (en) 2003-01-02 2015-11-03 FemmeParma Holding Company, Inc. Pharmaceutical preparations for treatments of diseases and disorders of the breast
WO2004060322A2 (en) * 2003-01-02 2004-07-22 Femmepharma Holding Company, Inc. Pharmaceutical preparations for treatments of diseases and disorders of the breast
DE10315878B4 (en) * 2003-04-08 2009-06-04 Schwarz Pharma Ag Device for transdermal administration of fesoterodine and use
DK1670433T3 (en) 2003-10-10 2012-03-12 Ferring Bv Transdermal pharmaceutical formulation to reduce skin remnants
TW200514582A (en) * 2003-10-31 2005-05-01 Hisamitsu Pharmaceutical Co Transdermal preparation and method for reducing side effect in pergolide therapy
US7425340B2 (en) * 2004-05-07 2008-09-16 Antares Pharma Ipl Ag Permeation enhancing compositions for anticholinergic agents
WO2007124250A2 (en) * 2006-04-21 2007-11-01 Antares Pharma Ipl Ag Methods of treating hot flashes with formulations for transdermal or transmucosal application
WO2006125642A1 (en) 2005-05-27 2006-11-30 Antares Pharma Ipl Ag Methods and apparatus for transdermal or transmucosal application of testosterone
JP5097359B2 (en) 2006-05-09 2012-12-12 久光製薬株式会社 Donepezil transdermal preparation
WO2008067991A2 (en) * 2006-12-08 2008-06-12 Antares Pharma Ipl Ag Skin-friendly drug complexes for transdermal administration
WO2008083158A2 (en) * 2006-12-26 2008-07-10 Femmepharma Holding Company, Inc. Topical administration of danazol
TWI630208B (en) 2008-12-08 2018-07-21 歐陸斯迪公司 Dihydroetorphine
US8920392B2 (en) 2009-05-05 2014-12-30 Watson Laboratories, Inc. Method for treating overactive bladders and a device for storage and administration of topical oxybutynin compositions
US20110003000A1 (en) * 2009-07-06 2011-01-06 Femmepharma Holding Company, Inc. Transvaginal Delivery of Drugs
AU2011245499B2 (en) 2010-04-30 2014-09-25 Merck Sharp & Dohme Corp. Novel beta 3 adrenergic receptor agonists
US20160151321A1 (en) 2012-11-13 2016-06-02 Dinesh C. Patel Methods for the treatment of sialorrhea
US20140135392A1 (en) * 2012-11-13 2014-05-15 NeuRx Pharmaceuticals LLC Methods for the treatment of sialorrhea
GB201309654D0 (en) 2013-05-30 2013-07-17 Euro Celtique Sa Method
EP4122460A1 (en) 2015-01-09 2023-01-25 Chase Pharmaceuticals Corporation Oxybutynin transdermal therapeutic system combination
US20170239183A1 (en) * 2016-02-23 2017-08-24 PixarBio Corporation COMPOSITIONS COMPRISING NAv1.7 SELECTIVE INHIBITORS FOR TREATING ACUTE, POST-OPERATIVE, OR CHRONIC PAIN AND METHODS OF USING THE SAME
WO2019026844A1 (en) 2017-08-01 2019-02-07 久光製薬株式会社 Adhesive patch

Family Cites Families (57)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US147236A (en) * 1874-02-10 Improvement in devices for riveting the teeth of saws
NL124473C (en) * 1960-07-26
US5736577A (en) 1995-01-31 1998-04-07 Sepracor, Inc. Methods and compositions for treating urinary incontinence using optically pure (S)-oxybutynin
JPS60100516A (en) 1983-11-04 1985-06-04 Takeda Chem Ind Ltd Preparation of sustained release microcapsule
US4959217A (en) 1986-05-22 1990-09-25 Syntex (U.S.A.) Inc. Delayed/sustained release of macromolecules
US5028430A (en) 1987-05-08 1991-07-02 Syntex (U.S.A.) Inc. Delivery systems for the controlled administration of LHRH analogs
US5641504A (en) 1988-06-09 1997-06-24 Alza Corporation Skin permeation enhancer compositions using glycerol monolinoleate
US5721275A (en) * 1989-06-07 1998-02-24 Bazzano; Gail S. Slow release vehicles for minimizing skin irritancy of topical compositions
US5922342A (en) 1990-10-01 1999-07-13 Pharmacia & Upjohn Company Lateral edge coated controlled release pharmaceutical compositions
US5164190A (en) * 1990-12-11 1992-11-17 Theratech, Inc. Subsaturated transdermal drug delivery device exhibiting enhanced drug flux
US5152997A (en) 1990-12-11 1992-10-06 Theratech, Inc. Method and device for transdermally administering testosterone across nonscrotal skin at therapeutically effective levels
US5227169A (en) 1991-05-17 1993-07-13 Theratech, Inc. Sorbitan esters as skin permeation enhancers
US5212199A (en) 1991-05-17 1993-05-18 Theratech, Inc. Sorbitan esters as skin permeation enhancers
PT100502A (en) 1991-05-20 1993-08-31 Alza Corp PHARMACEUTICAL COMPOSITIONS FOR INCREASING THE CAPACITY OF PERMEACAO IN THE SKIN USING GLYCEROL MONOLINOLEATE
AU670777B2 (en) * 1992-04-16 1996-08-01 Ortho Pharmaceutical Corporation Aqueous gel vehicles for retinoids
ES2137261T3 (en) * 1992-05-13 1999-12-16 Alza Corp TRANSDERMIC ADMINISTRATION OF OXYBUTININE.
US5900250A (en) * 1992-05-13 1999-05-04 Alza Corporation Monoglyceride/lactate ester permeation enhancer for oxybutnin
JP3277342B2 (en) 1992-09-02 2002-04-22 武田薬品工業株式会社 Manufacturing method of sustained release microcapsules
WO1995009007A1 (en) 1993-09-29 1995-04-06 Alza Corporation Monoglyceride/lactate ester permeation enhancer for oxybutynin
WO1995024172A1 (en) 1994-03-07 1995-09-14 Theratech, Inc. Drug-containing adhesive composite transdermal delivery device
US5441740A (en) * 1994-05-06 1995-08-15 Longevity Network. Ltd. Cosmetic composition containing alpha hydroxyacids, salicyclic acid, and enzyme mixture of bromelain and papain
ZA954599B (en) 1994-06-07 1996-01-26 Allergan Inc Stable gel formulation for topical treatment of skin conditions
US5635203A (en) 1994-09-29 1997-06-03 Alza Corporation Transdermal device having decreased delamination
EP0782861B1 (en) * 1994-10-05 2001-12-12 Hisamitsu Pharmaceutical Co., Inc. Drug compounding ingredients comprising n-substituted-o-toluidine derivative and percutaneously absorbable preparation
US5516808A (en) 1994-10-27 1996-05-14 Sawaya; Assad S. Topical cellulose pharmaceutical formulation
US5582838A (en) * 1994-12-22 1996-12-10 Merck & Co., Inc. Controlled release drug suspension delivery device
US5562917A (en) * 1994-12-23 1996-10-08 Pentech Pharmaceuticals, Inc. Transdermal administration of apomorphine
US5532278A (en) 1995-01-31 1996-07-02 Sepracor, Inc. Methods and compositions for treating urinary incontinence using optically pure (S)-oxybutynin
US5677346A (en) 1995-01-31 1997-10-14 Sepracor, Inc. Treating urinary incontinence using (S)-desethyloxybutynin
US5862555A (en) 1995-04-06 1999-01-26 Furuhashi; Masanobu System and method for manufacturing shoes using a wooden mold
US5601839A (en) * 1995-04-26 1997-02-11 Theratech, Inc. Triacetin as a penetration enhancer for transdermal delivery of a basic drug
US5912268A (en) 1995-05-22 1999-06-15 Alza Corporation Dosage form and method for treating incontinence
US5674895A (en) 1995-05-22 1997-10-07 Alza Corporation Dosage form comprising oxybutynin
US5759583A (en) 1995-08-30 1998-06-02 Syntex (U.S.A.) Inc. Sustained release poly (lactic/glycolic) matrices
EP1238659B1 (en) 1996-02-02 2004-09-29 ALZA Corporation Sustained delivery of an active agent using an implantable system
US6096339A (en) * 1997-04-04 2000-08-01 Alza Corporation Dosage form, process of making and using same
IT1283102B1 (en) * 1996-06-06 1998-04-07 Permatec Nv THERAPEUTIC COMPOSITION FOR THE TRANSDERMAL ADMINISTRATION OF AN ESTROGENIC OR PROGESTINIC ACTIVE SUBSTANCE OR OF THEIR MIXTURES
US5783208A (en) 1996-07-19 1998-07-21 Theratech, Inc. Transdermal drug delivery matrix for coadministering estradiol and another steroid
US5762953A (en) 1996-08-22 1998-06-09 Theratech, Inc. Transdermal propentofylline compositions for the treatment of Alzheimers disease
US5985317A (en) 1996-09-06 1999-11-16 Theratech, Inc. Pressure sensitive adhesive matrix patches for transdermal delivery of salts of pharmaceutical agents
US5769683A (en) * 1997-02-10 1998-06-23 Park; Young-Ho Attachment for balloon tether
US6203817B1 (en) 1997-02-19 2001-03-20 Alza Corporation Reduction of skin reactions caused by transdermal drug delivery
US6479373B2 (en) * 1997-02-20 2002-11-12 Infineon Technologies Ag Method of structuring layers with a polysilicon layer and an overlying metal or metal silicide layer using a three step etching process with fluorine, chlorine, bromine containing gases
ATE246489T1 (en) 1997-03-31 2003-08-15 Alza Corp IMPLANTABLE DIFFUSION DELIVERY SYSTEM
US6039967A (en) 1997-04-03 2000-03-21 Point Biomedical Corporation Intravesical drug delivery system
US5948433A (en) 1997-08-21 1999-09-07 Bertek, Inc. Transdermal patch
NZ504423A (en) 1997-11-10 2003-04-29 Cellegy Pharma Inc Composition having enhanced penetration capabilities and irritation reducing systems
US5891888A (en) * 1998-01-14 1999-04-06 Strahl; Robert Charles Physical endurance drink
DE29823343U1 (en) 1998-03-20 1999-07-15 Sanol Arznei Schwarz Gmbh Transdermal therapeutic system (TTS) containing oxybutynin
AR018321A1 (en) 1998-03-26 2001-11-14 Alza Corp A DOSAGE FORM OF PROLONGED LIBERATION THAT INCLUDES OXIBUTININE AND THE USES OF OXIBUTININE AND THE DOSAGE FORM OF PROLONGED LIBERATION.
US5986305A (en) * 1998-03-30 1999-11-16 Texas Instruments - Acer Incorporated Semiconductor device with an inverse-T gate lightly-doped drain structure
FR2779438B1 (en) * 1998-06-03 2004-12-24 Jean Marc Aiache STABLE GEL, PREPARATION METHOD THEREOF, AND PHARMACEUTICAL COMPOSITIONS COMPRISING THE SAME
US6562368B2 (en) 1999-12-16 2003-05-13 Dermatrends, Inc. Transdermal administration of oxybutynin using hydroxide-releasing agents as permeation enhancers
EP1992342A1 (en) * 2000-04-26 2008-11-19 Watson Pharmaceuticals, Inc. Minimizing adverse experience associated with oxybutynin therapy
US6682368B2 (en) * 2000-05-31 2004-01-27 Tyco Electronics Corporation Electrical connector assembly utilizing multiple ground planes
US6545046B2 (en) 2000-08-30 2003-04-08 Theramax Inc. Method for enhanced delivery of oxybutynin and compositions thereof
US6662368B1 (en) * 2000-09-11 2003-12-09 Arris International, Inc. Variable spare circuit group size and quantity having multiple active circuits

Also Published As

Publication number Publication date
CN1438861A (en) 2003-08-27
US7081252B2 (en) 2006-07-25
MXPA02010542A (en) 2003-10-14
WO2001080796A1 (en) 2001-11-01
CN102327253A (en) 2012-01-25
DK1280486T3 (en) 2011-02-14
US20060078613A1 (en) 2006-04-13
DE60143477D1 (en) 2010-12-30
EP2322170A1 (en) 2011-05-18
US20040120996A1 (en) 2004-06-24
BR0110381A (en) 2003-12-30
CA2406064C (en) 2011-03-15
EP1280486A1 (en) 2003-02-05
JP2013082720A (en) 2013-05-09
AU5378201A (en) 2001-11-07
US7087241B2 (en) 2006-08-08
JP6253734B2 (en) 2017-12-27
JP2003531157A (en) 2003-10-21
CN101305994A (en) 2008-11-19
JP6077294B2 (en) 2017-02-08
CY1111498T1 (en) 2015-08-05
US6743441B2 (en) 2004-06-01
US7081250B2 (en) 2006-07-25
JP2017008085A (en) 2017-01-12
ES2357699T3 (en) 2011-04-28
US20040259954A1 (en) 2004-12-23
EP1992342A1 (en) 2008-11-19
EP1280486B1 (en) 2010-11-17
AU2001253782B2 (en) 2006-06-29
ATE488233T1 (en) 2010-12-15
EP1280486A4 (en) 2006-03-29
US7081249B2 (en) 2006-07-25
PT1280486E (en) 2011-02-28
HK1052287A1 (en) 2003-09-11
CN101843601A (en) 2010-09-29
US20050048107A1 (en) 2005-03-03
US20050048106A1 (en) 2005-03-03
US20020147236A1 (en) 2002-10-10
US7081251B2 (en) 2006-07-25
MX342305B (en) 2016-09-23

Similar Documents

Publication Publication Date Title
CA2406064A1 (en) Minimizing adverse experience associated with oxybutynin therapy
WO2004041188A3 (en) Compositions and methods for transdermal oxybutynin therapy
US20040214849A1 (en) Parenteral administration of 6-hydroxy-oxymorphone for use as an analgesic
US10888533B2 (en) Transdermal composition containing donepezil as active ingredient
AU2023204240A1 (en) Donepezil transdermal delivery system
CA2344090A1 (en) Compositions and methods for treating female sexual dysfunction
WO2008019996A3 (en) Formulations of flibanserin and method for manufacturing the same
WO2009120002A3 (en) Percutaneous preparation containing donepezil as active ingredient for treatment of dementia
WO2011028794A2 (en) Treatment of huntington's disease with cycloserine and an nmda receptor antagonist
WO2005115432A3 (en) Treatment of ocular diseases and disorders using lantibiotic compositions
WO2006047392A3 (en) Nicotinic-opioid synergy for analgesia
Khurmi et al. Randomized double-blind comparison of gallopamil and propranolol in stable angina pectoris
CA2459470A1 (en) Pharmaceutical composition comprising gabapentin or an analogue thereof and an .alpha.-aminoamide and its analgesic use
WO2001034125A3 (en) Therapeutic use and formulation of (-)-tramadol
MX2008006037A (en) Once-daily administration of central nervous system drugs.
US6395752B1 (en) Method of treating depression using 1-threo-methylphenidate
WO2008154339A9 (en) Extended release formulation and method of treating adrenergic dysregulation
US20070105817A1 (en) Use of cicletanine and other furopyridines for treatment of systolic-predominant hypertension, isolated systolic hypertension, elevated pulse pressure, and general hypertension
Kuzel Ropinirole: a dopamine agonist for the treatment of Parkinson’s disease
US10149828B2 (en) Oxybutynin transdermal therapeutic system combination
WO2008131256A1 (en) Improved treatments for premature ejaculation in humans
AU726341B2 (en) A combination preparation containing tramadol and a calcium channel antagonist
WO2004041187A3 (en) Compositions and methods for transdermal oxybutynin therapy
WO2010019279A8 (en) Pharmaceutical compositions configured to deter dosage form splitting
Ekelund et al. Effects of felodipine versus nifedipine on exercise tolerance in stable angina pectoris

Legal Events

Date Code Title Description
EEER Examination request
MKEX Expiry

Effective date: 20210426