CA2404618A1 - Electrically-conductive patterns for monitoring the filling of medical devices - Google Patents

Electrically-conductive patterns for monitoring the filling of medical devices Download PDF

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Publication number
CA2404618A1
CA2404618A1 CA002404618A CA2404618A CA2404618A1 CA 2404618 A1 CA2404618 A1 CA 2404618A1 CA 002404618 A CA002404618 A CA 002404618A CA 2404618 A CA2404618 A CA 2404618A CA 2404618 A1 CA2404618 A1 CA 2404618A1
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CA
Canada
Prior art keywords
conductive
layer
flow channel
conductive surface
insulating pattern
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA002404618A
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French (fr)
Other versions
CA2404618C (en
Inventor
Robert Justice Shartle
Timothy J. Ohara
Mahyar Z. Kermani
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
LifeScan Inc
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Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2404618A1 publication Critical patent/CA2404618A1/en
Application granted granted Critical
Publication of CA2404618C publication Critical patent/CA2404618C/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
    • G01N27/26—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
    • G01N27/28—Electrolytic cell components
    • G01N27/30—Electrodes, e.g. test electrodes; Half-cells
    • G01N27/327—Biochemical electrodes, e.g. electrical or mechanical details for in vitro measurements
    • G01N27/3271—Amperometric enzyme electrodes for analytes in body fluids, e.g. glucose in blood
    • G01N27/3272—Test elements therefor, i.e. disposable laminated substrates with electrodes, reagent and channels

Abstract

A flexible diagnostic device has a measurement cell that is sandwiched between the conductive surfaces of two conductive-coated insulating layers. At least one of the conductive surfaces is scored with an insulating pattern, so that the flow of a conductive fluid sample into the cell can be monitored.

Claims (16)

1. A medical diagnostic device for measuring an analyte concentration of an electrically conductive biological fluid, comprising a multilayer structure having a first layer and a second layer sandwiching an intermediate layer, a) the first and second layers each comprising an insulating sheet, having a conductive surface adjoining the intermediate layer, b) the intermediate layer being an insulating layer with a cutout, having a first end and a second end, which, together with the first and second layers, defines a flow channel to permit the sample to flow from the first end to the second end, c) the flow channel comprising (i) a dry reagent on the conductive surface of one of the layers for reacting with the sample to yield a change in an electrical parameter that can be related to the analyte concentration of the fluid and (ii) an electrochemical cell, within which the electrical parameter is measured, d) the conductive surface of one of the layers having a first insulating pattern scored into its conductive surface to divide the second layer into two regions, insulated from each other, whereby sample that flows across the pattern provides a conductive path from the first end to the second end.
2. The device of claim 1, in which the first end of the. cutout is at a first edge of the intermediate layer and the second end is at a second edge of the intermediate layer, opposite the first edge.
3. The device of claim 1, in which the dry reagent is on the conductive surface of the first layer and the insulating pattern is scored into the conductive surface of the second layer.
4. The device of claim 1, in which sample that enters the flow channel at the first end flows through the electrochemical cell, before it reaches the first insulating pattern.
5. The device of claim 1, in which the biological fluid is blood and the analyte being measured is glucose.
6. The device of claim 1, in which the first and second layers each comprise metallized thermoplastic sheets.
7. The device of claim 1, in which the intermediate layer comprises a thermoplastic sheet having adhesive on both surfaces for adhering to the first and second layers.
8. The device of claim 1, in which the reagent on the conductive surface comprises a buffer, a mediator, and an enzyme.
9. The device of claim 1, in which the flow channel is a capillary channel and the insulating pattern scored into the conductive surface has at least one serration within the flow channel.
10. The device of claim 9, in which the insulating pattern has at least one serration within the flow channel pointing toward each end of the channel.
11. The device of claim 1, further comprising a second insulating pattern scored into the conductive surface of the scored layer between the first end and the first insulating pattern to divide the scored layer into three regions, insulated from each other.
12. The device of claim 11, in which sample that enters the flow channel at the first end reaches the second insulating pattern before it flows through the electrochemical cell.
13. The device of claim 1, further comprising electrical circuit means for detecting the flow of fluid through the flow channel.
14. A method for preparing an electrically-conductive pattern comprising passing a web of a conductive-coated flexible insulator between a cutting die and anvil, in which the cutting die has a cutting element that is raised a height greater than the thickness of the conductive coating for scoring through preselected portions of the conductive coating.
15. The method of claim 14, in which the cutting die and anvil are rollers.
16. The method of claim 14, in which the conductive coating has a thickness in the range from about 5 to about 100 nm and the cutting element is raised about one thousand times the coating thickness.
CA2404618A 2000-03-31 2001-03-23 Electrically-conductive patterns for monitoring the filling of medical devices Expired - Lifetime CA2404618C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US54031900A 2000-03-31 2000-03-31
US09/540,319 2000-03-31
PCT/US2001/009471 WO2001075438A2 (en) 2000-03-31 2001-03-23 Electrically-conductive patterns for monitoring the filling of medical devices

Publications (2)

Publication Number Publication Date
CA2404618A1 true CA2404618A1 (en) 2001-10-11
CA2404618C CA2404618C (en) 2011-06-14

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
CA2404618A Expired - Lifetime CA2404618C (en) 2000-03-31 2001-03-23 Electrically-conductive patterns for monitoring the filling of medical devices

Country Status (18)

Country Link
US (3) US20040068165A1 (en)
EP (1) EP1292825B1 (en)
JP (1) JP4679784B2 (en)
KR (1) KR20020097206A (en)
CN (1) CN1191475C (en)
AR (1) AR028307A1 (en)
AT (1) ATE337551T1 (en)
AU (2) AU5096801A (en)
CA (1) CA2404618C (en)
DE (1) DE60122517T2 (en)
ES (1) ES2269377T3 (en)
HK (1) HK1052384B (en)
IL (1) IL151914A0 (en)
MX (1) MXPA02009661A (en)
PL (1) PL365420A1 (en)
RU (1) RU2267131C2 (en)
TW (1) TW576920B (en)
WO (1) WO2001075438A2 (en)

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Publication number Publication date
HK1052384A1 (en) 2003-09-11
US20050059872A1 (en) 2005-03-17
KR20020097206A (en) 2002-12-31
AR028307A1 (en) 2003-05-07
DE60122517T2 (en) 2007-03-08
US20040068165A1 (en) 2004-04-08
RU2267131C2 (en) 2005-12-27
US20060200021A1 (en) 2006-09-07
TW576920B (en) 2004-02-21
ATE337551T1 (en) 2006-09-15
AU2001250968B2 (en) 2005-09-15
JP2003529765A (en) 2003-10-07
RU2002125857A (en) 2004-03-10
DE60122517D1 (en) 2006-10-05
CN1432132A (en) 2003-07-23
EP1292825B1 (en) 2006-08-23
EP1292825A2 (en) 2003-03-19
IL151914A0 (en) 2003-04-10
US7548772B2 (en) 2009-06-16
AU5096801A (en) 2001-10-15
WO2001075438A3 (en) 2002-06-13
CN1191475C (en) 2005-03-02
MXPA02009661A (en) 2004-07-30
JP4679784B2 (en) 2011-04-27
ES2269377T3 (en) 2007-04-01
WO2001075438A2 (en) 2001-10-11
HK1052384B (en) 2007-02-09
US7050843B2 (en) 2006-05-23
PL365420A1 (en) 2005-01-10
CA2404618C (en) 2011-06-14

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