CA2402637A1 - Valve for osmotic devices - Google Patents
Valve for osmotic devices Download PDFInfo
- Publication number
- CA2402637A1 CA2402637A1 CA002402637A CA2402637A CA2402637A1 CA 2402637 A1 CA2402637 A1 CA 2402637A1 CA 002402637 A CA002402637 A CA 002402637A CA 2402637 A CA2402637 A CA 2402637A CA 2402637 A1 CA2402637 A1 CA 2402637A1
- Authority
- CA
- Canada
- Prior art keywords
- valve
- osmotic
- agent
- beneficial agent
- reservoir
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0002—Galenical forms characterised by the drug release technique; Application systems commanded by energy
- A61K9/0004—Osmotic delivery systems; Sustained release driven by osmosis, thermal energy or gas
Abstract
An osmotic delivery system for controlled delivery of a beneficial agent includes an implant capsule having a beneficial agent reservoir, an osmotic agent which expands on contact with fluid imbibed through a permeable membrane retained by the implant capsule, a delivery port, and a valve for opening and closing the delivery port. When the osmotic agent expands, a pressure is exerted against a separating member positioned between the beneficial agent reservoir and the osmotic agent. The separating member moves within the capsule, thereby forcing the valve to move a distance such that the beneficial agent can exit the reservoir through the delivery port.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US17130599P | 1999-12-21 | 1999-12-21 | |
US60/171,305 | 1999-12-21 | ||
PCT/US2000/034314 WO2001045675A2 (en) | 1999-12-21 | 2000-12-13 | Valve for osmotic devices |
Publications (2)
Publication Number | Publication Date |
---|---|
CA2402637A1 true CA2402637A1 (en) | 2001-06-28 |
CA2402637C CA2402637C (en) | 2007-04-10 |
Family
ID=22623268
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CA002402637A Expired - Fee Related CA2402637C (en) | 1999-12-21 | 2000-12-13 | Valve for osmotic devices |
Country Status (11)
Country | Link |
---|---|
US (2) | US6508808B1 (en) |
EP (1) | EP1328256B1 (en) |
KR (1) | KR100734187B1 (en) |
AT (1) | ATE306908T1 (en) |
AU (1) | AU773354B2 (en) |
CA (1) | CA2402637C (en) |
DE (1) | DE60023361T2 (en) |
DK (1) | DK1328256T3 (en) |
ES (1) | ES2248156T3 (en) |
HK (1) | HK1055680A1 (en) |
WO (1) | WO2001045675A2 (en) |
Families Citing this family (51)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6440457B1 (en) * | 1993-05-27 | 2002-08-27 | Alza Corporation | Method of administering antidepressant dosage form |
MY125870A (en) * | 1997-07-25 | 2006-08-30 | Alza Corp | Osmotic delivery system flow modulator apparatus and method |
US7258869B1 (en) * | 1999-02-08 | 2007-08-21 | Alza Corporation | Stable non-aqueous single phase viscous vehicles and formulations utilizing such vehicle |
US7919109B2 (en) | 1999-02-08 | 2011-04-05 | Intarcia Therapeutics, Inc. | Stable non-aqueous single phase viscous vehicles and formulations utilizing such vehicles |
ES2248156T3 (en) * | 1999-12-21 | 2006-03-16 | Alza Corporation | VALVE FOR OSMOTIC DEVICES. |
US6929636B1 (en) * | 2000-11-08 | 2005-08-16 | Hewlett-Packard Development Company, L.P. | Internal drug dispenser capsule medical device |
DE60315474T2 (en) * | 2002-06-17 | 2008-04-24 | Alza Corp., Mountain View | OSMOTIC DISTRIBUTION SYSTEMS WITH OSMOTIC DRIVE AND METHOD FOR PRODUCING BOTH THE OSMOTIC DRIVE AND THE OSMOTIC DELIVERY SYSTEM |
US7014636B2 (en) * | 2002-11-21 | 2006-03-21 | Alza Corporation | Osmotic delivery device having a two-way valve and a dynamically self-adjusting flow channel |
US7731947B2 (en) * | 2003-11-17 | 2010-06-08 | Intarcia Therapeutics, Inc. | Composition and dosage form comprising an interferon particle formulation and suspending vehicle |
US20040224903A1 (en) * | 2002-12-19 | 2004-11-11 | Stephen Berry | Stable, non-aqueous, single-phase gels and formulations thereof for delivery from an implantable device |
AR043810A1 (en) * | 2003-03-31 | 2005-08-17 | Alza Corp | OSMOTIC SYSTEM OF ADMINISTRATION AND METHOD TO DECREASE TIMES OF ARRIVAL IN THE OPERATING REGIME IN OSMOTIC SYSTEMS OF ADMINISTRATION |
CA2520775A1 (en) * | 2003-03-31 | 2004-10-21 | Alza Corporation | Non-aqueous single phase vehicles and formulations utilizing such vehicles |
JP2006521897A (en) * | 2003-03-31 | 2006-09-28 | アルザ・コーポレーション | Osmotic pump with means for dissipating internal pressure |
CN1874763A (en) * | 2003-11-06 | 2006-12-06 | 阿尔扎公司 | Modular imbibition rate reducer for use with implantable osmotic pump |
US20050175701A1 (en) * | 2004-02-10 | 2005-08-11 | Alza Corporation | Capillary moderator for osmotic delivery system |
US20050266087A1 (en) * | 2004-05-25 | 2005-12-01 | Gunjan Junnarkar | Formulations having increased stability during transition from hydrophobic vehicle to hydrophilic medium |
US7350479B2 (en) * | 2004-09-10 | 2008-04-01 | United States Of America As Represented By The Secretary Of The Army | System and method for controlling growth of aquatic plants utilizing bio-eroding means implanted in triploid grass carp |
US11246913B2 (en) | 2005-02-03 | 2022-02-15 | Intarcia Therapeutics, Inc. | Suspension formulation comprising an insulinotropic peptide |
EP2361630A1 (en) * | 2005-02-03 | 2011-08-31 | Intarcia Therapeutics, Inc | Implantable drug delivery device comprising particles and an osmotic pump |
WO2006083761A2 (en) | 2005-02-03 | 2006-08-10 | Alza Corporation | Solvent/polymer solutions as suspension vehicles |
US7959938B2 (en) | 2005-03-15 | 2011-06-14 | Intarcia Therapeutics, Inc. | Polyoxaester suspending vehicles for use with implantable delivery systems |
US20070027105A1 (en) | 2005-07-26 | 2007-02-01 | Alza Corporation | Peroxide removal from drug delivery vehicle |
DE602007009377D1 (en) | 2006-05-30 | 2010-11-04 | Intarcia Therapeutics Inc | SECONDARY FLOW MODULATOR WITH AN INTERNAL CHANNEL FOR AN OSMOTIC OUTPUT SYSTEM |
CN102274557B (en) | 2006-08-09 | 2014-12-03 | 精达制药公司 | Osmotic delivery systems and piston assemblies |
US7538652B2 (en) * | 2006-08-29 | 2009-05-26 | International Business Machines Corporation | Electrical component tuned by conductive layer deletion |
DK2157967T3 (en) | 2007-04-23 | 2013-04-08 | Intarcia Therapeutics Inc | Suspension formulations of insulinotropic peptides and applications thereof |
FI7960U1 (en) * | 2007-04-27 | 2008-07-28 | Bayer Schering Pharma Oy | Membrane shell for an implantable dosing system |
US8343140B2 (en) * | 2008-02-13 | 2013-01-01 | Intarcia Therapeutics, Inc. | Devices, formulations, and methods for delivery of multiple beneficial agents |
US8028743B2 (en) * | 2008-04-17 | 2011-10-04 | Hewlett-Packard Development Company, L.P. | Passive cooling in response to ambient environmental properties |
NZ592113A (en) * | 2008-10-15 | 2012-04-27 | Intarcia Therapeutics Inc | Highly concentrated drug particles, formulations, suspensions and uses thereof |
CA2979355C (en) * | 2009-05-18 | 2023-02-21 | Dose Medical Corporation | Drug eluting ocular implant |
LT2462246T (en) | 2009-09-28 | 2017-11-27 | Intarcia Therapeutics, Inc | Rapid establishment and/or termination of substantial steady-state drug delivery |
US20110311606A1 (en) * | 2010-06-18 | 2011-12-22 | Coldren Bret A | Punctal plugs with continuous or pulsatile drug release mechanism |
US20120208755A1 (en) | 2011-02-16 | 2012-08-16 | Intarcia Therapeutics, Inc. | Compositions, Devices and Methods of Use Thereof for the Treatment of Cancers |
US20130090633A1 (en) * | 2011-10-07 | 2013-04-11 | University Of Southern California | Osmotic patch pump |
US9889085B1 (en) | 2014-09-30 | 2018-02-13 | Intarcia Therapeutics, Inc. | Therapeutic methods for the treatment of diabetes and related conditions for patients with high baseline HbA1c |
CN113598842A (en) | 2015-06-03 | 2021-11-05 | 因塔西亚制药公司 | Implant placement and removal system |
WO2017027376A1 (en) | 2015-08-07 | 2017-02-16 | Massachusetts Institute Of Technology | Subcutaneous drug delivery device with manual activation and deactivation of drug release |
US11925578B2 (en) | 2015-09-02 | 2024-03-12 | Glaukos Corporation | Drug delivery implants with bi-directional delivery capacity |
IL258904B (en) | 2015-11-05 | 2022-09-01 | Massachusetts Gen Hospital | Intrathecal delivery of nucleic acid sequences encoding abcd1 for treatment of adrenomyeloneuropathy |
EP3458084B1 (en) | 2016-05-16 | 2020-04-01 | Intarcia Therapeutics, Inc | Glucagon-receptor selective polypeptides and methods of use thereof |
USD840030S1 (en) | 2016-06-02 | 2019-02-05 | Intarcia Therapeutics, Inc. | Implant placement guide |
USD860451S1 (en) | 2016-06-02 | 2019-09-17 | Intarcia Therapeutics, Inc. | Implant removal tool |
US10406336B2 (en) * | 2016-08-03 | 2019-09-10 | Neil S. Davey | Adjustable rate drug delivery implantable device |
CA3040906A1 (en) | 2016-10-20 | 2018-04-26 | Peptron, Inc. | Methods of delivering a neuroprotective polypeptide to the central nervous system |
EP3565580B1 (en) | 2017-01-03 | 2024-03-06 | i2o Therapeutics, Inc. | Continuous administration of exenatide and co-adminstration of acetaminophen, ethinylestradiol or levonorgestrel |
MX2019010651A (en) | 2017-03-08 | 2020-01-13 | Intarcia Therapeutics Inc | Apparatus and methods for administration of a nauseogenic compound from a drug delivery device. |
CN115568457A (en) * | 2018-03-16 | 2023-01-06 | 诺埃尔·埃尔曼 | Controlled release device and method for integrating an active ingredient into a matrix |
USD933219S1 (en) | 2018-07-13 | 2021-10-12 | Intarcia Therapeutics, Inc. | Implant removal tool and assembly |
CN113195524A (en) | 2018-10-11 | 2021-07-30 | 因塔西亚治疗公司 | Human amylin analog polypeptides and methods of use |
BR112022013784A2 (en) | 2020-01-13 | 2022-10-11 | Durect Corp | DISTRIBUTION SYSTEMS FOR PROLONGED RELEASE DRUGS WITH REDUCED IMPURITIES AND RELATED METHODS |
Family Cites Families (34)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US2168437A (en) | 1935-04-10 | 1939-08-08 | Kenneth O Buercklin | Injection device |
US3995631A (en) | 1971-01-13 | 1976-12-07 | Alza Corporation | Osmotic dispenser with means for dispensing active agent responsive to osmotic gradient |
US3732865A (en) | 1971-01-13 | 1973-05-15 | Alza Corp | Osmotic dispenser |
US3995632A (en) | 1973-05-04 | 1976-12-07 | Alza Corporation | Osmotic dispenser |
US4111202A (en) | 1976-11-22 | 1978-09-05 | Alza Corporation | Osmotic system for the controlled and delivery of agent over time |
US4243030A (en) | 1978-08-18 | 1981-01-06 | Massachusetts Institute Of Technology | Implantable programmed microinfusion apparatus |
US4373527B1 (en) | 1979-04-27 | 1995-06-27 | Univ Johns Hopkins | Implantable programmable medication infusion system |
US4350271A (en) | 1980-08-22 | 1982-09-21 | Alza Corporation | Water absorbing fluid dispenser |
US4340054A (en) | 1980-12-29 | 1982-07-20 | Alza Corporation | Dispenser for delivering fluids and solids |
US4439196A (en) | 1982-03-18 | 1984-03-27 | Merck & Co., Inc. | Osmotic drug delivery system |
US4455143A (en) | 1982-03-22 | 1984-06-19 | Alza Corporation | Osmotic device for dispensing two different medications |
US4552561A (en) | 1982-12-23 | 1985-11-12 | Alza Corporation | Body mounted pump housing and pump assembly employing the same |
US4639244A (en) | 1983-05-03 | 1987-01-27 | Nabil I. Rizk | Implantable electrophoretic pump for ionic drugs and associated methods |
US4865845A (en) | 1986-03-21 | 1989-09-12 | Alza Corporation | Release rate adjustment of osmotic or diffusional delivery devices |
US5034229A (en) | 1988-12-13 | 1991-07-23 | Alza Corporation | Dispenser for increasing feed conversion of hog |
ES2046039T3 (en) | 1989-11-13 | 1994-01-16 | Becton Dickinson France | STORAGE BOTTLE CONTAINING A COMPONENT OF A MEDICINAL SOLUTION. |
US5030216A (en) | 1989-12-15 | 1991-07-09 | Alza Corporation | Osmotically driven syringe |
US5122128A (en) | 1990-03-15 | 1992-06-16 | Alza Corporation | Orifice insert for a ruminal bolus |
US5151093A (en) | 1990-10-29 | 1992-09-29 | Alza Corporation | Osmotically driven syringe with programmable agent delivery |
GB9027422D0 (en) | 1990-12-18 | 1991-02-06 | Scras | Osmotically driven infusion device |
US5861166A (en) | 1991-03-12 | 1999-01-19 | Alza Corporation | Delivery device providing beneficial agent stability |
NZ244682A (en) | 1991-10-10 | 1993-12-23 | Alza Corp | Osmotically driven controlled delivery device characterised in that a |
US5223265A (en) | 1992-01-10 | 1993-06-29 | Alza Corporation | Osmotic device with delayed activation of drug delivery |
US5456679A (en) | 1992-02-18 | 1995-10-10 | Alza Corporation | Delivery devices with pulsatile effect |
US5308348A (en) * | 1992-02-18 | 1994-05-03 | Alza Corporation | Delivery devices with pulsatile effect |
US5221278A (en) | 1992-03-12 | 1993-06-22 | Alza Corporation | Osmotically driven delivery device with expandable orifice for pulsatile delivery effect |
GB9223146D0 (en) | 1992-11-05 | 1992-12-16 | Scherer Corp R P | Vented capsule |
US5639477A (en) | 1993-06-23 | 1997-06-17 | Alza Corporation | Ruminal drug delivery device |
US5498255A (en) * | 1993-08-17 | 1996-03-12 | Alza Corporation | Osmotic device for protracted pulsatile delivery of agent |
DE69734168T2 (en) | 1996-02-02 | 2006-01-19 | Alza Corp., Mountain View | Implantable system with delayed release of active ingredient |
ZA981610B (en) * | 1997-03-24 | 1999-08-26 | Alza Corp | Self adjustable exit port. |
DE69822208T2 (en) * | 1997-12-29 | 2005-04-28 | Alza Corp., Mountain View | OSMOTIC ADMINISTRATION SYSTEM WITH PUSHROOM RESTRAINT MECHANISM |
PT1140014E (en) * | 1998-12-31 | 2003-07-31 | Alza Corp | OSMOTICAL DISTRIBUTION SYSTEM THAT HAS BOTTLE WITH EFFECTIVE USE OF SPACE |
ES2248156T3 (en) * | 1999-12-21 | 2006-03-16 | Alza Corporation | VALVE FOR OSMOTIC DEVICES. |
-
2000
- 2000-12-13 ES ES00984483T patent/ES2248156T3/en not_active Expired - Lifetime
- 2000-12-13 AT AT00984483T patent/ATE306908T1/en not_active IP Right Cessation
- 2000-12-13 EP EP00984483A patent/EP1328256B1/en not_active Expired - Lifetime
- 2000-12-13 CA CA002402637A patent/CA2402637C/en not_active Expired - Fee Related
- 2000-12-13 AU AU21095/01A patent/AU773354B2/en not_active Ceased
- 2000-12-13 DE DE60023361T patent/DE60023361T2/en not_active Expired - Lifetime
- 2000-12-13 WO PCT/US2000/034314 patent/WO2001045675A2/en active IP Right Grant
- 2000-12-13 KR KR1020027008287A patent/KR100734187B1/en not_active IP Right Cessation
- 2000-12-13 DK DK00984483T patent/DK1328256T3/en active
- 2000-12-21 US US09/748,099 patent/US6508808B1/en not_active Expired - Lifetime
-
2002
- 2002-12-04 US US10/310,742 patent/US6682522B2/en not_active Expired - Lifetime
-
2003
- 2003-11-05 HK HK03107967A patent/HK1055680A1/en not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
WO2001045675A8 (en) | 2003-05-22 |
US6508808B1 (en) | 2003-01-21 |
CA2402637C (en) | 2007-04-10 |
WO2001045675A3 (en) | 2002-01-03 |
AU2109501A (en) | 2001-07-03 |
EP1328256B1 (en) | 2005-10-19 |
DE60023361T2 (en) | 2006-04-27 |
ATE306908T1 (en) | 2005-11-15 |
US20030093063A1 (en) | 2003-05-15 |
ES2248156T3 (en) | 2006-03-16 |
EP1328256A2 (en) | 2003-07-23 |
KR100734187B1 (en) | 2007-07-02 |
DK1328256T3 (en) | 2006-02-20 |
DE60023361D1 (en) | 2005-11-24 |
KR20030009336A (en) | 2003-01-29 |
US6682522B2 (en) | 2004-01-27 |
WO2001045675A2 (en) | 2001-06-28 |
AU773354B2 (en) | 2004-05-20 |
HK1055680A1 (en) | 2004-01-21 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
EEER | Examination request | ||
MKLA | Lapsed |