CA2401610A1 - Improved mobility spectrometer - Google Patents
Improved mobility spectrometer Download PDFInfo
- Publication number
- CA2401610A1 CA2401610A1 CA002401610A CA2401610A CA2401610A1 CA 2401610 A1 CA2401610 A1 CA 2401610A1 CA 002401610 A CA002401610 A CA 002401610A CA 2401610 A CA2401610 A CA 2401610A CA 2401610 A1 CA2401610 A1 CA 2401610A1
- Authority
- CA
- Canada
- Prior art keywords
- mobility spectrometer
- sensitivity
- realized
- improved mobility
- preserving
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
- G01N27/62—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating the ionisation of gases, e.g. aerosols; by investigating electric discharges, e.g. emission of cathode
- G01N27/622—Ion mobility spectrometry
- G01N27/623—Ion mobility spectrometry combined with mass spectrometry
-
- H—ELECTRICITY
- H01—ELECTRIC ELEMENTS
- H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
- H01J49/00—Particle spectrometers or separator tubes
- H01J49/02—Details
- H01J49/06—Electron- or ion-optical arrangements
-
- H—ELECTRICITY
- H01—ELECTRIC ELEMENTS
- H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
- H01J49/00—Particle spectrometers or separator tubes
- H01J49/26—Mass spectrometers or separator tubes
- H01J49/34—Dynamic spectrometers
- H01J49/40—Time-of-flight spectrometers
- H01J49/401—Time-of-flight spectrometers characterised by orthogonal acceleration, e.g. focusing or selecting the ions, pusher electrode
Abstract
The present invention relates to an improved ion mobility spectrometer and method for the analysis of chemical samples. The improvements are realized in the optimization of resolution and sensitivity. Increases in sensitivity are realized by preserving a narrow spatial distribution of migrating ions through the use of periodic/hyperbolic field focusing. Additionally, novel combinations and configurations of components are used to simultaneously maintain a well defined ion packet and preserve sample throughput to the detector.
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US18578100P | 2000-02-29 | 2000-02-29 | |
US60/185,781 | 2000-02-29 | ||
US19365900P | 2000-03-31 | 2000-03-31 | |
US60/193,659 | 2000-03-31 | ||
PCT/US2001/006405 WO2001064320A1 (en) | 2000-02-29 | 2001-02-28 | Improved mobility spectrometer |
Publications (2)
Publication Number | Publication Date |
---|---|
CA2401610A1 true CA2401610A1 (en) | 2001-09-07 |
CA2401610C CA2401610C (en) | 2009-10-06 |
Family
ID=26881466
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CA002401610A Expired - Fee Related CA2401610C (en) | 2000-02-29 | 2001-02-28 | Improved mobility spectrometer |
Country Status (5)
Country | Link |
---|---|
US (2) | US6897437B2 (en) |
EP (1) | EP1268041B1 (en) |
AU (2) | AU2001247243A1 (en) |
CA (1) | CA2401610C (en) |
WO (2) | WO2001065589A1 (en) |
Families Citing this family (84)
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US7071465B2 (en) | 2003-10-14 | 2006-07-04 | Washington State University Research Foundation | Ion mobility spectrometry method and apparatus |
US6992284B2 (en) * | 2003-10-20 | 2006-01-31 | Ionwerks, Inc. | Ion mobility TOF/MALDI/MS using drift cell alternating high and low electrical field regions |
EP1690074A2 (en) * | 2003-11-25 | 2006-08-16 | Sionex Corporation | Mobility based apparatus and methods using dispersion characteristics, sample fragmentation, and/or pressure control to improve analysis of a sample |
US7170052B2 (en) * | 2003-12-31 | 2007-01-30 | Ionwerks, Inc. | MALDI-IM-ortho-TOF mass spectrometry with simultaneous positive and negative mode detection |
US20100090101A1 (en) * | 2004-06-04 | 2010-04-15 | Ionwerks, Inc. | Gold implantation/deposition of biological samples for laser desorption two and three dimensional depth profiling of biological tissues |
US20070187591A1 (en) * | 2004-06-10 | 2007-08-16 | Leslie Bromberg | Plasma ion mobility spectrometer |
JP2006032109A (en) * | 2004-07-15 | 2006-02-02 | Jeol Ltd | Orthogonal acceleration time-of-flight mass spectroscope |
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DE102004045315A1 (en) * | 2004-09-17 | 2006-03-30 | Gesellschaft zur Förderung angewandter Optik, Optoelektronik, Quantenelektronik und Spektroskopie e.V. | Time of Flight Mass Spectrometer |
DE102004048496B4 (en) | 2004-10-05 | 2008-04-30 | Bruker Daltonik Gmbh | Ion guide with RF diaphragm stacks |
GB0424426D0 (en) | 2004-11-04 | 2004-12-08 | Micromass Ltd | Mass spectrometer |
GB2458602B (en) * | 2005-02-03 | 2009-11-18 | Bruker Daltonik Gmbh | Transport of ions into a vacuum |
US7482582B2 (en) * | 2005-05-27 | 2009-01-27 | Ionwerks, Inc. | Multi-beam ion mobility time-of-flight mass spectrometry with multi-channel data recording |
US7429729B2 (en) * | 2005-05-27 | 2008-09-30 | Ionwerks, Inc. | Multi-beam ion mobility time-of-flight mass spectrometer with bipolar ion extraction and zwitterion detection |
GB0808344D0 (en) | 2008-05-08 | 2008-06-18 | Owlstone Ltd | Sensor |
US20070125943A1 (en) * | 2005-12-07 | 2007-06-07 | Hagerman James G | Horn mass spectrometer having blade deflectors |
JP5555428B2 (en) * | 2006-02-08 | 2014-07-23 | ディーエイチ テクノロジーズ デベロップメント プライベート リミテッド | Radio frequency ion guide |
US10073056B2 (en) * | 2006-02-14 | 2018-09-11 | Excellims Corporation | Practical ion mobility spectrometer apparatus and methods for chemical and/or biological detection |
US10309929B2 (en) * | 2006-02-14 | 2019-06-04 | Excellims Corporation | Practical ion mobility spectrometer apparatus and methods for chemical and/or biological detection |
US8785848B2 (en) * | 2007-07-11 | 2014-07-22 | Excellims Corporation | Parallel ion mass and ion mobility analysis |
DE102006006683B4 (en) * | 2006-02-14 | 2008-02-21 | Bruker Daltonik Gmbh | Drift tube for ion mobility spectrometer with integrated gas channel |
WO2007095203A2 (en) * | 2006-02-14 | 2007-08-23 | Excellims Corporation | Ion mobility spectrometer apparatus and methods |
WO2008094288A2 (en) * | 2006-06-29 | 2008-08-07 | Ionwerks, Inc. | Neutral/ion reactor in adiabatic supersonic gas flow for ion mobility time-of flight mass spectrometry |
US10794862B2 (en) * | 2006-11-28 | 2020-10-06 | Excellims Corp. | Practical ion mobility spectrometer apparatus and methods for chemical and/or biological detection |
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US7880137B2 (en) * | 2007-12-28 | 2011-02-01 | Morpho Detection, Inc. | Electrode design for an ion spectrometer |
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CN101603943B (en) * | 2008-06-12 | 2012-11-21 | 同方威视技术股份有限公司 | Electrode structure for migration tube in mobility spectrum instrument |
US10566169B1 (en) * | 2008-06-30 | 2020-02-18 | Nexgen Semi Holding, Inc. | Method and device for spatial charged particle bunching |
US8969795B2 (en) * | 2008-10-06 | 2015-03-03 | Shimadzu Corporation | Curtain gas filter for mass- and mobility-analyzers that excludes ion-source gases and ions of high mobility |
US7838823B1 (en) * | 2008-12-16 | 2010-11-23 | Sandia Corporation | Ion mobility spectrometer with virtual aperture grid |
US8518663B2 (en) * | 2009-04-27 | 2013-08-27 | The Charles Stark Draper Laboratory, Inc. | Rapid detection of volatile organic compounds for identification of Mycobacterium tuberculosis in a sample |
US8138472B2 (en) * | 2009-04-29 | 2012-03-20 | Academia Sinica | Molecular ion accelerator |
CN102522309B (en) * | 2009-06-30 | 2014-11-19 | 同方威视技术股份有限公司 | Ion collection device of ion mobility spectrometer and ion mobility spectrometer |
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CN102522308B (en) * | 2009-06-30 | 2014-07-30 | 同方威视技术股份有限公司 | Ion mobility spectrometer and ion collection device thereof |
GB201021360D0 (en) | 2010-12-16 | 2011-01-26 | Thermo Fisher Scient Bremen Gmbh | Apparatus and methods for ion mobility spectrometry |
CN103165394B (en) * | 2011-12-16 | 2015-12-02 | 同方威视技术股份有限公司 | The electrode structure of transference tube and comprise the transference tube of this structure |
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GB201205009D0 (en) * | 2012-03-22 | 2012-05-09 | Micromass Ltd | Multi-dimensional survey scans for improved data dependent acquisitions (DDA) |
WO2014021960A1 (en) * | 2012-07-31 | 2014-02-06 | Leco Corporation | Ion mobility spectrometer with high throughput |
US9459194B2 (en) | 2013-03-14 | 2016-10-04 | Cardio Metrix | Apparatuses, processes, and systems for measuring particle size distribution and concentration |
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US9281173B2 (en) | 2013-05-30 | 2016-03-08 | Agilent Technologies, Inc. | Ion processing utilizing segmented vacuum manifold |
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JP6445021B2 (en) * | 2014-01-02 | 2018-12-26 | ディーエイチ テクノロジーズ デベロップメント プライベート リミテッド | Homogenization of the pulsed electric field generated in a ring stack ion accelerator |
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EP3155640A4 (en) * | 2014-06-16 | 2018-07-04 | Purdue Research Foundation | Sample analysis systems and methods of use thereof |
US9564305B2 (en) * | 2014-07-29 | 2017-02-07 | Smiths Detection Inc. | Ion funnel for efficient transmission of low mass-to-charge ratio ions with reduced gas flow at the exit |
CN104576286A (en) * | 2014-12-31 | 2015-04-29 | 同方威视技术股份有限公司 | Electrode rings for ion migration spectrometer, iron migration tube and iron migration spectrometer |
GB201519830D0 (en) * | 2015-11-10 | 2015-12-23 | Micromass Ltd | A method of transmitting ions through an aperture |
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-
2001
- 2001-02-28 AU AU2001247243A patent/AU2001247243A1/en not_active Abandoned
- 2001-02-28 CA CA002401610A patent/CA2401610C/en not_active Expired - Fee Related
- 2001-02-28 WO PCT/US2001/006398 patent/WO2001065589A1/en active Application Filing
- 2001-02-28 AU AU2001243328A patent/AU2001243328A1/en not_active Abandoned
- 2001-02-28 US US09/798,030 patent/US6897437B2/en not_active Expired - Lifetime
- 2001-02-28 US US09/798,032 patent/US6639213B2/en not_active Expired - Fee Related
- 2001-02-28 EP EP01920160A patent/EP1268041B1/en not_active Expired - Lifetime
- 2001-02-28 WO PCT/US2001/006405 patent/WO2001064320A1/en active Application Filing
Also Published As
Publication number | Publication date |
---|---|
EP1268041B1 (en) | 2012-09-05 |
US20010032930A1 (en) | 2001-10-25 |
US6897437B2 (en) | 2005-05-24 |
WO2001064320A1 (en) | 2001-09-07 |
CA2401610C (en) | 2009-10-06 |
US20010032929A1 (en) | 2001-10-25 |
AU2001243328A1 (en) | 2001-09-12 |
AU2001247243A1 (en) | 2001-09-12 |
EP1268041A4 (en) | 2008-02-06 |
EP1268041A1 (en) | 2003-01-02 |
WO2001065589A1 (en) | 2001-09-07 |
US6639213B2 (en) | 2003-10-28 |
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MKLA | Lapsed |