CA2400305A1 - Generation of spatially-averaged excitation-emission map in heterogeneous tissue - Google Patents
Generation of spatially-averaged excitation-emission map in heterogeneous tissue Download PDFInfo
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
- G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
- G01N21/64—Fluorescence; Phosphorescence
- G01N21/645—Specially adapted constructive features of fluorimeters
- G01N21/6456—Spatial resolved fluorescence measurements; Imaging
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/0059—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
- G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
- G01N21/64—Fluorescence; Phosphorescence
- G01N21/6486—Measuring fluorescence of biological material, e.g. DNA, RNA, cells
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
- G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
- G01N21/64—Fluorescence; Phosphorescence
- G01N2021/6417—Spectrofluorimetric devices
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
- G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
- G01N21/64—Fluorescence; Phosphorescence
- G01N2021/6417—Spectrofluorimetric devices
- G01N2021/6419—Excitation at two or more wavelengths
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
- G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
- G01N21/64—Fluorescence; Phosphorescence
- G01N2021/6417—Spectrofluorimetric devices
- G01N2021/6423—Spectral mapping, video display
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
- G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
- G01N21/64—Fluorescence; Phosphorescence
- G01N21/645—Specially adapted constructive features of fluorimeters
- G01N2021/6484—Optical fibres
Abstract
An instrument for evaluating fluorescence of a heterogeneous tissue includes means for exciting a two-dimensional portion of the tissue surface with excitation radiation at a plurality of excitation wavelengths, means for collecting emission radiation from the two-dimensional portion of the tissue surface simultaneously with excitation of the portion, and means for forming a two-dimensional excitation-emission map of the excitation radiation and the simultaneously collected emission radiation and spatially averaging the excitation and emission radiation.
Description
GENERATION OF SPATIALLY-AVERAGED
EXCITATION-EMISSION MAP IN HETEROGENEOUS TISSUE
Background of the Invention 1. Field of the Invention This invention relates to the rapid ge~-.eration of in vivo tissue auto-fluorescence spectra, and in particular to methods and devices for the acquisition of two-dimensional fluorescence excitation-emission maps, useful in the evaluation of heterogeneous tissues.
EXCITATION-EMISSION MAP IN HETEROGENEOUS TISSUE
Background of the Invention 1. Field of the Invention This invention relates to the rapid ge~-.eration of in vivo tissue auto-fluorescence spectra, and in particular to methods and devices for the acquisition of two-dimensional fluorescence excitation-emission maps, useful in the evaluation of heterogeneous tissues.
2. Description of the Background Tissue fluorescence has been used extensively for various medical purposes, including diagnosing disease, such as cancer of the cervix, assessment of skin aging, and monitoring tissue analytes.
A fluorescent species, i.e., fluorophore, will absorb incident light, and 1 S re-emit it at a longer wavelength. Therefore, unlike absorption spectroscopy, fluorescence spectra can only be completely characterized by studying the relationships between emission and excitation found on a two-dimensional excitation-emission map.
However, due to conventional instrumentation constraints, excitation-emission maps have been sparingly used until recently. Instead, spectra taken from a projection onto either the excitation or emission axes, i.e., only varying the excitation or emission wavelengths, have been gathered. For example, emission scans, which involve excitation of the sample with a single wavelength and scanning the sample's emissions, have been popular because they can utilize a laser light source. Further, excitation scans require generating illumination over many wavelengths, and so are typically performed with a continuous-spectrum light source. However, because the spectrum is recorded at a constant emission wavelength, excitation scans require the use of sensitive photomultiplier detectors.
Both emission and excitation scans, as well as synchronous scans, in which both excitation and excitation wavelengths are simultaneously incremented, have been extensively described in the literature. In addition, for homogeneous samples prepared in a cuvette, at least one commercial manufacturer offers an instrument which gathers an excitation-emission map at once in a cuvette. It does this by spreading the excitation beam along the length of the cuvette. The full spectrum excites any homogeneous sample. The resulting fluorescence is then collected and diffracted in the orthogonal direction. This process results in a two-dimensional excitation/emission S image, which is collected with a two-dimensional CCD device.
This instrument depends upon sample homogeneity to work. However, in vivo tissues are quite inhomogeneous, and so would not be suitable for use with this instrument (even if taken ex vivo and placed in a cuvette). In fact, this inhomogeneity is a problem with in vivo fluorescence, as many spectra at different sites must be obtained and averaged in order to get a representative spectrum.
Consequently, there is a need for a device that can be used to gather and process fluorescent spectra from tissue in vivo, despite any inhomogeneity which may be present in the tissue.
Summary of the Invention The present invention overcomes the problems and disadvantages associated with current strategies and designs and provides a device useful for analyzing heterogeneous tissues in vivo. The present invention applies the technique of gathering an excitation-emission map simultaneously, using a two-dimensional CCD or similar photon detector, to in vivo tissue, while at the same time ameliorating the inhomogeneity problem that plagues in vivo fluorescence spectroscopy.
Accordingly, one embodiment of the invention is directed to a method for evaluating fluorescence of a heterogeneous tissue comprising the steps of exciting a two- dimensional portion of the tissue surface with excitation radiation at a plurality of excitation wavelengths, collecting emission radiation from the two-dimensional portion of the tissue surface simultaneously with excitation, and forming a two-dimensional excitation-emission map of the excitation radiation and the simultaneously collected emission radiation and spatially averaging the excitation and emission radiation.
A fluorescent species, i.e., fluorophore, will absorb incident light, and 1 S re-emit it at a longer wavelength. Therefore, unlike absorption spectroscopy, fluorescence spectra can only be completely characterized by studying the relationships between emission and excitation found on a two-dimensional excitation-emission map.
However, due to conventional instrumentation constraints, excitation-emission maps have been sparingly used until recently. Instead, spectra taken from a projection onto either the excitation or emission axes, i.e., only varying the excitation or emission wavelengths, have been gathered. For example, emission scans, which involve excitation of the sample with a single wavelength and scanning the sample's emissions, have been popular because they can utilize a laser light source. Further, excitation scans require generating illumination over many wavelengths, and so are typically performed with a continuous-spectrum light source. However, because the spectrum is recorded at a constant emission wavelength, excitation scans require the use of sensitive photomultiplier detectors.
Both emission and excitation scans, as well as synchronous scans, in which both excitation and excitation wavelengths are simultaneously incremented, have been extensively described in the literature. In addition, for homogeneous samples prepared in a cuvette, at least one commercial manufacturer offers an instrument which gathers an excitation-emission map at once in a cuvette. It does this by spreading the excitation beam along the length of the cuvette. The full spectrum excites any homogeneous sample. The resulting fluorescence is then collected and diffracted in the orthogonal direction. This process results in a two-dimensional excitation/emission S image, which is collected with a two-dimensional CCD device.
This instrument depends upon sample homogeneity to work. However, in vivo tissues are quite inhomogeneous, and so would not be suitable for use with this instrument (even if taken ex vivo and placed in a cuvette). In fact, this inhomogeneity is a problem with in vivo fluorescence, as many spectra at different sites must be obtained and averaged in order to get a representative spectrum.
Consequently, there is a need for a device that can be used to gather and process fluorescent spectra from tissue in vivo, despite any inhomogeneity which may be present in the tissue.
Summary of the Invention The present invention overcomes the problems and disadvantages associated with current strategies and designs and provides a device useful for analyzing heterogeneous tissues in vivo. The present invention applies the technique of gathering an excitation-emission map simultaneously, using a two-dimensional CCD or similar photon detector, to in vivo tissue, while at the same time ameliorating the inhomogeneity problem that plagues in vivo fluorescence spectroscopy.
Accordingly, one embodiment of the invention is directed to a method for evaluating fluorescence of a heterogeneous tissue comprising the steps of exciting a two- dimensional portion of the tissue surface with excitation radiation at a plurality of excitation wavelengths, collecting emission radiation from the two-dimensional portion of the tissue surface simultaneously with excitation, and forming a two-dimensional excitation-emission map of the excitation radiation and the simultaneously collected emission radiation and spatially averaging the excitation and emission radiation.
Another embodiment is directed to an instrument for evaluating fluorescence of a heterogeneous tissue comprising means for exciting a two-dimensional portion of the tissue surface with excitation radiation at a plurality of excitation wavelengths, means for collecting emission radiation from the two-s dimensional portion of the tissue surface simultaneously with excitation, and means for forming a two-dimensional excitation-emission map of the excitation radiation and the simultaneously collected emission radiation and spatially averaging the excitation and emission radiation.
Another embodiment is directed to a method of rapidly gathering UV
and visible fluorescence spectra in vivo which have been spatially averaged over tissue, the method comprising the steps of illuminating strips of tissue with excitation radiation simultaneously at a plurality of excitation wavelengths, collecting emission radiation simultaneously from the strips of tissue with the step of illuminating with the plurality of excitation wavelengths, and disposing the emission radiation onto a two-dimensional array of detector elements, wherein the two-dimensional detector disposition is arranged by wavelength to form a two-dimensional excitation-emission map, in which all elements in the map are collected at once.
Still another embodiment is directed to an instrument for rapidly gathering UV and visible fluorescence spectra in vivo which have been spatially averaged over tissue, the method comprising means for illuminating strips of tissue with excitation radiation simultaneously at a plurality of excitation wavelengths, means for collecting emission radiation simultaneously from the strips of tissue with the step of illuminating with the plurality of excitation wavelengths, and means for disposing the emission radiation onto a two-dimensional array of detector elements, wherein the two-dimensional detector disposition is arranged by wavelength to form a two-dimensional excitation-emission map, in which all elements in the map are collected at once.
Another embodiment is directed to a method of rapidly gathering UV
and visible fluorescence spectra in vivo which have been spatially averaged over tissue, the method comprising the steps of illuminating strips of tissue with excitation radiation simultaneously at a plurality of excitation wavelengths, collecting emission radiation simultaneously from the strips of tissue with the step of illuminating with the plurality of excitation wavelengths, and disposing the emission radiation onto a two-dimensional array of detector elements, wherein the two-dimensional detector disposition is arranged by wavelength to form a two-dimensional excitation-emission map, in which all elements in the map are collected at once.
Still another embodiment is directed to an instrument for rapidly gathering UV and visible fluorescence spectra in vivo which have been spatially averaged over tissue, the method comprising means for illuminating strips of tissue with excitation radiation simultaneously at a plurality of excitation wavelengths, means for collecting emission radiation simultaneously from the strips of tissue with the step of illuminating with the plurality of excitation wavelengths, and means for disposing the emission radiation onto a two-dimensional array of detector elements, wherein the two-dimensional detector disposition is arranged by wavelength to form a two-dimensional excitation-emission map, in which all elements in the map are collected at once.
Other embodiments and advantages of the invention are set forth in part in the description which follows, and in part, will be obvious from this description, or may be learned from the practice of the invention.
Description of the Drawings Figure 1 A schematic of an instrument of a preferred embodiment of the invention.
Figure 2 A schematic of the fiber optic heads of the instrument of Figure 1.
Description of the Invention As embodied and broadly described herein, the present invention is directed to methods and devices for the acquisition of two-dimensional fluorescence excitation-emission maps, useful in the evaluation of non-homogenous tissues.
The present invention applies the technique of gathering an excitation-emission map simultaneously, using a two-dimensional CCD or similar photon detector, to in vivo tissue, while at the same time ameliorating the inhomogeneity problem that plagues in vivo fluorescence spectroscopy.
An important feature of the present invention is the spatial averaging of the excitation and emission radiation. In contrast to the prior art, in which excitation was spread into a line so that each spectral region illuminated only a very small sample patch, in the present invention a substantial strip or area of tissue is illuminated, thus spatially averaging over the sample.
In a preferred embodiment, this function is performed with a large fiber bundle, so that no moving parts are present. In alternate, less-preferred embodiments, the strip may be generated over time by sequentially scanning, using a moving mirror or other beam steering device.
A preferred embodiment of an instrument according to the invention is diagrammed in Figure 1, and the fiber optic heads of the instrument are shown in more detail in Figure 2.
Refernng to Figure 1, three-dimensional fluorescence spectrometer 10 comprises a light source 12. Light source 12 is preferably a UV-visible light source.
Light source 12 may be a continuous source with a shutter 14 or, more preferably, a flash lamp. Excitation radiation at a plurality of excitation wavelengths from light source 12 passes through bandpass filter 16 where it strikes excitation grating 18. From excitation grating 18, the excitation radiation is directed through excitation lens 20 to 5 excitation optical fiber head 22. As will be clear to those of skill in the art, the excitation optics spectrally disperse the incident radiation and lead it to the excitation optical fiber head 22.
Excitation radiation then passes from excitation optical fiber head 22 via fiber optic bundle 24 to common fiber optic head 30. Excitation radiation from excitation fibers in common fiber optic head 30 is directed to the tissue or surface of interest 32.
Fluorescent radiation emitted from the tissue is then picked up by emission fibers in common fiber optic head 30. The collected emission radiation is transmitted via emission fiber optic bundle 34 to emission fiber optic head 36. From emission fiber optic head 36, the collected radiation passes through emission lens 38 to the emission optics, i.e., emission grating 40. From emission grating 40, the collected radiation is sent to a two-dimensional CCD detector or similar photon detector 42.
The emission radiation is collected by a two-dimensional array of detector elements disposed in common fiber optic head 30. The two-dimensional detector disposition is arranged by wavelength to form a two-dimensional excitation-emission map in which all elements in the map are collected at once. Both the excitation and emission maps are gathered simultaneously using two-dimensional CCD
42. Spatial averaging of the excitation and emission radiation is then used to ameliorate any problems due to inhomogeneity.
Figure 2 depicts a detailed schematic of excitation fiber optic head 22, common fiber optic head 30 and emission fiber optic head 36 according to a preferred embodiment of the invention. Referring to Figure 2, excitation fiber optic head 22 preferably measures 28 x 3 mm and comprises 15 fiber bundles 50, each fiber bundle containing 20 fibers.
Description of the Drawings Figure 1 A schematic of an instrument of a preferred embodiment of the invention.
Figure 2 A schematic of the fiber optic heads of the instrument of Figure 1.
Description of the Invention As embodied and broadly described herein, the present invention is directed to methods and devices for the acquisition of two-dimensional fluorescence excitation-emission maps, useful in the evaluation of non-homogenous tissues.
The present invention applies the technique of gathering an excitation-emission map simultaneously, using a two-dimensional CCD or similar photon detector, to in vivo tissue, while at the same time ameliorating the inhomogeneity problem that plagues in vivo fluorescence spectroscopy.
An important feature of the present invention is the spatial averaging of the excitation and emission radiation. In contrast to the prior art, in which excitation was spread into a line so that each spectral region illuminated only a very small sample patch, in the present invention a substantial strip or area of tissue is illuminated, thus spatially averaging over the sample.
In a preferred embodiment, this function is performed with a large fiber bundle, so that no moving parts are present. In alternate, less-preferred embodiments, the strip may be generated over time by sequentially scanning, using a moving mirror or other beam steering device.
A preferred embodiment of an instrument according to the invention is diagrammed in Figure 1, and the fiber optic heads of the instrument are shown in more detail in Figure 2.
Refernng to Figure 1, three-dimensional fluorescence spectrometer 10 comprises a light source 12. Light source 12 is preferably a UV-visible light source.
Light source 12 may be a continuous source with a shutter 14 or, more preferably, a flash lamp. Excitation radiation at a plurality of excitation wavelengths from light source 12 passes through bandpass filter 16 where it strikes excitation grating 18. From excitation grating 18, the excitation radiation is directed through excitation lens 20 to 5 excitation optical fiber head 22. As will be clear to those of skill in the art, the excitation optics spectrally disperse the incident radiation and lead it to the excitation optical fiber head 22.
Excitation radiation then passes from excitation optical fiber head 22 via fiber optic bundle 24 to common fiber optic head 30. Excitation radiation from excitation fibers in common fiber optic head 30 is directed to the tissue or surface of interest 32.
Fluorescent radiation emitted from the tissue is then picked up by emission fibers in common fiber optic head 30. The collected emission radiation is transmitted via emission fiber optic bundle 34 to emission fiber optic head 36. From emission fiber optic head 36, the collected radiation passes through emission lens 38 to the emission optics, i.e., emission grating 40. From emission grating 40, the collected radiation is sent to a two-dimensional CCD detector or similar photon detector 42.
The emission radiation is collected by a two-dimensional array of detector elements disposed in common fiber optic head 30. The two-dimensional detector disposition is arranged by wavelength to form a two-dimensional excitation-emission map in which all elements in the map are collected at once. Both the excitation and emission maps are gathered simultaneously using two-dimensional CCD
42. Spatial averaging of the excitation and emission radiation is then used to ameliorate any problems due to inhomogeneity.
Figure 2 depicts a detailed schematic of excitation fiber optic head 22, common fiber optic head 30 and emission fiber optic head 36 according to a preferred embodiment of the invention. Referring to Figure 2, excitation fiber optic head 22 preferably measures 28 x 3 mm and comprises 15 fiber bundles 50, each fiber bundle containing 20 fibers.
Common fiber optic head 30 preferably measures 28 x 10 mm and comprises 15 linear mixed fiber arrays 52 from the excitation and emission bundles.
Preferably, each linear array 52 contains 40 fibers, 20 excitation fibers and 20 emission fibers.
Emission fiber optic head 36 preferably measures 28 x 3 mm and comprises 15 fiber bundles 54.
At the excitation end, each fiber bundle 50 preferably contains 20 optic fibers of 0.2 mm diameter, and collects narrowband light (bandwidth 8-20 nm) in a selected UV and visible wavelength region. The excitation wavelengths are preferably 250-550 nm, more preferably, 270-450 nm, and most preferably, 270-390 nm.
There is 0.8 mm space between each fiber bundle to mitigate cross-talk. Thus, in the preferred embodiment, there are 300 fibers in each bundle.
The emission fibers are also arranged in 15 fiber bundles 54 comprising fibers each at the emission end of the fiber bundle, arranged as the emission fibers.
15 At the common end, each linear fiber array 52 (10 mm long, containing 20 each of alternating excitation and emission fibers) delivers narrowband excitation light to a 10 mm strip of tissue. Different strips excite the tissue at different wavelengths and collect the fluorescence.
The arrangement depicted in Figure 2 provides the following 20 advantages:
1. The relatively large area of common head reduces the problem of inhomogeneity of tissue site by spatially averaging.
2. By using a 2-dimensional CCD array, the need for a moving detector system is eliminated. This speeds up collection as well as simplifies the design.
3. By collecting the spectra in parallel, rather than sequentially, UV
exposure on the tissue is minimized.
Other embodiments and uses of the invention will be apparent to those skilled in the art from consideration of the specification and practice of the invention disclosed herein. All references cited herein, including all U.S. and foreign patents and patent applications, are specifically and entirely hereby incorporated herein by reference, including, but not limited to, U.S. Patent Application No.
09/287,486, filed April 6, 1999. U.S. Patent Application titled "Multivariate Analysis of Green to Ultraviolet Spectra of Cell and Tissue Samples," U.S. Patent Application titled S "Reduction of Inter-Subject Variation Via Transfer Standardization," and U.S. Patent Application titled "Non-Invasive Tissue Glucose Level Monitoring," all filed contemporaneously herewith, are entirely and specifically incorporated by reference.
It is intended that the specification and examples be considered exemplary only, with the true scope and spirit of the invention indicated by the following claims.
Preferably, each linear array 52 contains 40 fibers, 20 excitation fibers and 20 emission fibers.
Emission fiber optic head 36 preferably measures 28 x 3 mm and comprises 15 fiber bundles 54.
At the excitation end, each fiber bundle 50 preferably contains 20 optic fibers of 0.2 mm diameter, and collects narrowband light (bandwidth 8-20 nm) in a selected UV and visible wavelength region. The excitation wavelengths are preferably 250-550 nm, more preferably, 270-450 nm, and most preferably, 270-390 nm.
There is 0.8 mm space between each fiber bundle to mitigate cross-talk. Thus, in the preferred embodiment, there are 300 fibers in each bundle.
The emission fibers are also arranged in 15 fiber bundles 54 comprising fibers each at the emission end of the fiber bundle, arranged as the emission fibers.
15 At the common end, each linear fiber array 52 (10 mm long, containing 20 each of alternating excitation and emission fibers) delivers narrowband excitation light to a 10 mm strip of tissue. Different strips excite the tissue at different wavelengths and collect the fluorescence.
The arrangement depicted in Figure 2 provides the following 20 advantages:
1. The relatively large area of common head reduces the problem of inhomogeneity of tissue site by spatially averaging.
2. By using a 2-dimensional CCD array, the need for a moving detector system is eliminated. This speeds up collection as well as simplifies the design.
3. By collecting the spectra in parallel, rather than sequentially, UV
exposure on the tissue is minimized.
Other embodiments and uses of the invention will be apparent to those skilled in the art from consideration of the specification and practice of the invention disclosed herein. All references cited herein, including all U.S. and foreign patents and patent applications, are specifically and entirely hereby incorporated herein by reference, including, but not limited to, U.S. Patent Application No.
09/287,486, filed April 6, 1999. U.S. Patent Application titled "Multivariate Analysis of Green to Ultraviolet Spectra of Cell and Tissue Samples," U.S. Patent Application titled S "Reduction of Inter-Subject Variation Via Transfer Standardization," and U.S. Patent Application titled "Non-Invasive Tissue Glucose Level Monitoring," all filed contemporaneously herewith, are entirely and specifically incorporated by reference.
It is intended that the specification and examples be considered exemplary only, with the true scope and spirit of the invention indicated by the following claims.
Claims (13)
1. A method for evaluating fluorescence of a heterogeneous tissue comprising:
exciting a two-dimensional portion of the tissue surface with excitation radiation at a plurality of excitation wavelengths;
collecting emission radiation from said two-dimensional portion of the tissue surface simultaneously with excitation of said portion; and forming a two-dimensional excitation-emission map of said excitation radiation and said simultaneously collected emission radiation and spatially averaging said excitation and emission radiation.
exciting a two-dimensional portion of the tissue surface with excitation radiation at a plurality of excitation wavelengths;
collecting emission radiation from said two-dimensional portion of the tissue surface simultaneously with excitation of said portion; and forming a two-dimensional excitation-emission map of said excitation radiation and said simultaneously collected emission radiation and spatially averaging said excitation and emission radiation.
2. An instrument for evaluating fluorescence of a heterogeneous tissue comprising:
means for exciting a two-dimensional portion of the tissue surface with excitation radiation at a plurality of excitation wavelengths;
means for collecting emission radiation from said two-dimensional portion of the tissue surface simultaneously with excitation of said portion;
and means for forming a two-dimensional excitation-emission map of said excitation radiation and said simultaneously collected emission radiation and spatially averaging said excitation and emission radiation.
means for exciting a two-dimensional portion of the tissue surface with excitation radiation at a plurality of excitation wavelengths;
means for collecting emission radiation from said two-dimensional portion of the tissue surface simultaneously with excitation of said portion;
and means for forming a two-dimensional excitation-emission map of said excitation radiation and said simultaneously collected emission radiation and spatially averaging said excitation and emission radiation.
3. A method of rapidly gathering UV and visible fluorescence spectra in vivo spatially averaged over tissue, said method comprising the steps of:
illuminating strips of tissue with excitation radiation simultaneously at a plurality of excitation wavelengths;
collecting emission radiation simultaneously from said strips of tissue with the step of illuminating with said plurality of excitation wavelengths;
and disposing said emission radiation onto a two-dimensional array of detector elements, wherein said two-dimensional detector disposition is arranged by wavelength to form a two-dimensional excitation-emission map, in which all elements in said map are collected at once.
illuminating strips of tissue with excitation radiation simultaneously at a plurality of excitation wavelengths;
collecting emission radiation simultaneously from said strips of tissue with the step of illuminating with said plurality of excitation wavelengths;
and disposing said emission radiation onto a two-dimensional array of detector elements, wherein said two-dimensional detector disposition is arranged by wavelength to form a two-dimensional excitation-emission map, in which all elements in said map are collected at once.
4. An instrument for rapidly gathering UV and visible fluorescence spectra in vivo spatially averaged over tissue, said method comprising:
means for illuminating strips of tissue with excitation radiation simultaneously at a plurality of excitation wavelengths;
means for collecting emission radiation simultaneously from said strips of tissue with the step of illuminating with said plurality of excitation wavelengths; and means for disposing said emission radiation onto a two-dimensional array of detector elements, wherein said two-dimensional detector disposition is arranged by wavelength to form a two-dimensional excitation-emission map, in which all elements in said map are collected at once.
means for illuminating strips of tissue with excitation radiation simultaneously at a plurality of excitation wavelengths;
means for collecting emission radiation simultaneously from said strips of tissue with the step of illuminating with said plurality of excitation wavelengths; and means for disposing said emission radiation onto a two-dimensional array of detector elements, wherein said two-dimensional detector disposition is arranged by wavelength to form a two-dimensional excitation-emission map, in which all elements in said map are collected at once.
5. A common fiber optic head comprising:
a plurality of excitation fiber optic bundles, wherein each excitation fiber optic bundle comprises one or more excitation fibers;
a plurality of emission fiber optic bundles, wherein each emission fiber optic bundle comprises one or more emission fibers; and wherein distal ends of said fiber optic bundles are disposed in a two-dimensional array.
a plurality of excitation fiber optic bundles, wherein each excitation fiber optic bundle comprises one or more excitation fibers;
a plurality of emission fiber optic bundles, wherein each emission fiber optic bundle comprises one or more emission fibers; and wherein distal ends of said fiber optic bundles are disposed in a two-dimensional array.
6. The common fiber optic head of claim 5, wherein said two-dimensional array consists of n rows and n columns, said distal ends of said excitation fiber optic bundles are disposed in all elements of every odd or even column, but not both, and said distal ends of said emission fiber optic bundles are disposed in all elements of every odd or even column, not occupied by said excitation fiber optic bundles.
7. The common fiber optic head of claim 5, wherein each of said fiber optic bundles contains 20 or more optic fibers.
8. The common fiber optic head of claim 6, wherein each of said excitation fibers carries excitation light having a wavelength between 250-550 nm.
9. The common fiber optic head of claim 8, wherein each column of said excitation fibers carries excitation light having a unique wavelength.
10. The common fiber optic head of claim 5, wherein said fiber optic bundles are spaced at least 0.5 mm apart.
11. The common fiber optic head of claim 5, wherein said emission fibers collect fluorescence emitted from a sample exposed to said excitation light.
12. A system comprising:
said common fiber optic head of claim 5;
an excitation radiation source; and an emission radiation detector.
said common fiber optic head of claim 5;
an excitation radiation source; and an emission radiation detector.
13. The system of claim 12 further comprising means for generating a two-dimensional excitation and emission radiation map in which all elements in said map are gathered at once.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US18334500P | 2000-02-18 | 2000-02-18 | |
| US60/183,345 | 2000-02-18 | ||
| PCT/US2001/005321 WO2001060247A1 (en) | 2000-02-18 | 2001-02-20 | Generation of spatially-averaged excitation-emission map in heterogeneous tissue |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA2400305A1 true CA2400305A1 (en) | 2001-08-23 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002400305A Abandoned CA2400305A1 (en) | 2000-02-18 | 2001-02-20 | Generation of spatially-averaged excitation-emission map in heterogeneous tissue |
Country Status (6)
| Country | Link |
|---|---|
| US (2) | US6597932B2 (en) |
| EP (1) | EP1257192A1 (en) |
| JP (1) | JP2003522578A (en) |
| AU (1) | AU2001237066A1 (en) |
| CA (1) | CA2400305A1 (en) |
| WO (1) | WO2001060247A1 (en) |
Families Citing this family (319)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5490505A (en) | 1991-03-07 | 1996-02-13 | Masimo Corporation | Signal processing apparatus |
| MX9702434A (en) | 1991-03-07 | 1998-05-31 | Masimo Corp | Signal processing apparatus. |
| US5638818A (en) | 1991-03-21 | 1997-06-17 | Masimo Corporation | Low noise optical probe |
| US8019400B2 (en) | 1994-10-07 | 2011-09-13 | Masimo Corporation | Signal processing apparatus |
| EP1905352B1 (en) | 1994-10-07 | 2014-07-16 | Masimo Corporation | Signal processing method |
| US6002952A (en) | 1997-04-14 | 1999-12-14 | Masimo Corporation | Signal processing apparatus and method |
| US6229856B1 (en) | 1997-04-14 | 2001-05-08 | Masimo Corporation | Method and apparatus for demodulating signals in a pulse oximetry system |
| AU4214199A (en) | 1998-06-03 | 1999-12-20 | Masimo Corporation | Stereo pulse oximeter |
| US7245953B1 (en) | 1999-04-12 | 2007-07-17 | Masimo Corporation | Reusable pulse oximeter probe and disposable bandage apparatii |
| USRE41912E1 (en) | 1998-10-15 | 2010-11-02 | Masimo Corporation | Reusable pulse oximeter probe and disposable bandage apparatus |
| US6721585B1 (en) | 1998-10-15 | 2004-04-13 | Sensidyne, Inc. | Universal modular pulse oximeter probe for use with reusable and disposable patient attachment devices |
| US6463311B1 (en) | 1998-12-30 | 2002-10-08 | Masimo Corporation | Plethysmograph pulse recognition processor |
| US6684090B2 (en) | 1999-01-07 | 2004-01-27 | Masimo Corporation | Pulse oximetry data confidence indicator |
| US6770028B1 (en) * | 1999-01-25 | 2004-08-03 | Masimo Corporation | Dual-mode pulse oximeter |
| US20020140675A1 (en) | 1999-01-25 | 2002-10-03 | Ali Ammar Al | System and method for altering a display mode based on a gravity-responsive sensor |
| US6360114B1 (en) | 1999-03-25 | 2002-03-19 | Masimo Corporation | Pulse oximeter probe-off detector |
| US6515273B2 (en) | 1999-08-26 | 2003-02-04 | Masimo Corporation | System for indicating the expiration of the useful operating life of a pulse oximetry sensor |
| US6950687B2 (en) | 1999-12-09 | 2005-09-27 | Masimo Corporation | Isolation and communication element for a resposable pulse oximetry sensor |
| US6377829B1 (en) | 1999-12-09 | 2002-04-23 | Masimo Corporation | Resposable pulse oximetry sensor |
| US6430525B1 (en) | 2000-06-05 | 2002-08-06 | Masimo Corporation | Variable mode averager |
| WO2002015781A1 (en) | 2000-08-18 | 2002-02-28 | Masimo Corporation | Dual-mode pulse oximeter |
| US20020075490A1 (en) * | 2000-12-20 | 2002-06-20 | Affymetrix, Inc. | System and method for addressable light-directed microarray printing |
| US7139598B2 (en) * | 2002-04-04 | 2006-11-21 | Veralight, Inc. | Determination of a measure of a glycation end-product or disease state using tissue fluorescence |
| US20070276199A1 (en) * | 2002-04-04 | 2007-11-29 | Ediger Marwood N | Determination of a Measure of a Glycation End-Product or Disease State Using Tissue Fluorescence |
| FR2824139B1 (en) * | 2001-04-27 | 2003-05-30 | Commissariat Energie Atomique | LUMINESCENCE MEASURING DEVICE WITH PREFILTRE EFFECT ELIMINATION |
| US6850787B2 (en) | 2001-06-29 | 2005-02-01 | Masimo Laboratories, Inc. | Signal component processor |
| US6697658B2 (en) | 2001-07-02 | 2004-02-24 | Masimo Corporation | Low power pulse oximeter |
| US7355512B1 (en) | 2002-01-24 | 2008-04-08 | Masimo Corporation | Parallel alarm processor |
| US6850788B2 (en) | 2002-03-25 | 2005-02-01 | Masimo Corporation | Physiological measurement communications adapter |
| JP3723845B2 (en) * | 2002-03-26 | 2005-12-07 | 国立大学法人富山大学 | Method and apparatus for measuring film thickness of organic thin film used in organic electroluminescence device |
| US8131332B2 (en) * | 2002-04-04 | 2012-03-06 | Veralight, Inc. | Determination of a measure of a glycation end-product or disease state using tissue fluorescence of various sites |
| US8140147B2 (en) * | 2002-04-04 | 2012-03-20 | Veralight, Inc. | Determination of a measure of a glycation end-product or disease state using a flexible probe to determine tissue fluorescence of various sites |
| US7486985B2 (en) * | 2002-08-05 | 2009-02-03 | Infraredx, Inc. | Near-infrared spectroscopic analysis of blood vessel walls |
| US7376456B2 (en) * | 2002-08-05 | 2008-05-20 | Infraredx, Inc. | Near-infrared spectroscopic analysis of blood vessel walls |
| US6970792B1 (en) | 2002-12-04 | 2005-11-29 | Masimo Laboratories, Inc. | Systems and methods for determining blood oxygen saturation values using complex number encoding |
| US7919713B2 (en) | 2007-04-16 | 2011-04-05 | Masimo Corporation | Low noise oximetry cable including conductive cords |
| US6920345B2 (en) | 2003-01-24 | 2005-07-19 | Masimo Corporation | Optical sensor including disposable and reusable elements |
| US7003338B2 (en) | 2003-07-08 | 2006-02-21 | Masimo Corporation | Method and apparatus for reducing coupling between signals |
| US7500950B2 (en) | 2003-07-25 | 2009-03-10 | Masimo Corporation | Multipurpose sensor port |
| US7254431B2 (en) | 2003-08-28 | 2007-08-07 | Masimo Corporation | Physiological parameter tracking system |
| US7483729B2 (en) | 2003-11-05 | 2009-01-27 | Masimo Corporation | Pulse oximeter access apparatus and method |
| US7438683B2 (en) | 2004-03-04 | 2008-10-21 | Masimo Corporation | Application identification sensor |
| WO2005087097A1 (en) | 2004-03-08 | 2005-09-22 | Masimo Corporation | Physiological parameter system |
| CA2464029A1 (en) | 2004-04-08 | 2005-10-08 | Valery Telfort | Non-invasive ventilation monitor |
| US20080319286A1 (en) * | 2004-05-24 | 2008-12-25 | Trent Ridder | Optical Probes for Non-Invasive Analyte Measurements |
| US7594151B2 (en) * | 2004-06-18 | 2009-09-22 | Qualcomm, Incorporated | Reverse link power control in an orthogonal system |
| US8452316B2 (en) | 2004-06-18 | 2013-05-28 | Qualcomm Incorporated | Power control for a wireless communication system utilizing orthogonal multiplexing |
| US7197692B2 (en) * | 2004-06-18 | 2007-03-27 | Qualcomm Incorporated | Robust erasure detection and erasure-rate-based closed loop power control |
| US7343186B2 (en) | 2004-07-07 | 2008-03-11 | Masimo Laboratories, Inc. | Multi-wavelength physiological monitor |
| US7532326B2 (en) * | 2004-07-07 | 2009-05-12 | Corcoran Timothy C | Multiple-label fluorescence imaging using excitation-emission matrices |
| US9341565B2 (en) | 2004-07-07 | 2016-05-17 | Masimo Corporation | Multiple-wavelength physiological monitor |
| US7937128B2 (en) | 2004-07-09 | 2011-05-03 | Masimo Corporation | Cyanotic infant sensor |
| US8036727B2 (en) | 2004-08-11 | 2011-10-11 | Glt Acquisition Corp. | Methods for noninvasively measuring analyte levels in a subject |
| US7254429B2 (en) | 2004-08-11 | 2007-08-07 | Glucolight Corporation | Method and apparatus for monitoring glucose levels in a biological tissue |
| US20060189871A1 (en) | 2005-02-18 | 2006-08-24 | Ammar Al-Ali | Portable patient monitor |
| WO2006094107A1 (en) | 2005-03-01 | 2006-09-08 | Masimo Laboratories, Inc. | Physiological parameter confidence measure |
| US8942639B2 (en) | 2005-03-15 | 2015-01-27 | Qualcomm Incorporated | Interference control in a wireless communication system |
| US8848574B2 (en) | 2005-03-15 | 2014-09-30 | Qualcomm Incorporated | Interference control in a wireless communication system |
| EP1861684A1 (en) * | 2005-03-16 | 2007-12-05 | M. Carolyn Tisone | Simultaneous recording of multispectral fluorescence signatures |
| EP1874178A4 (en) | 2005-04-13 | 2009-12-09 | Glucolight Corp | Method for data reduction and calibration of an oct-based blood glucose monitor |
| US7962188B2 (en) | 2005-10-14 | 2011-06-14 | Masimo Corporation | Robust alarm system |
| KR101097021B1 (en) | 2005-10-27 | 2011-12-20 | 콸콤 인코포레이티드 | Method and apparatus for estimating reverse link loading in a wireless communication system |
| EP2374407B1 (en) | 2005-11-29 | 2021-05-05 | Masimo Corporation | Optical sensor including disposable and reusable elements |
| US7859668B2 (en) * | 2005-12-15 | 2010-12-28 | Honeywell International Inc. | Apparatus and method for illuminator-independent color measurements |
| US7990382B2 (en) | 2006-01-03 | 2011-08-02 | Masimo Corporation | Virtual display |
| US8182443B1 (en) | 2006-01-17 | 2012-05-22 | Masimo Corporation | Drug administration controller |
| US20070244377A1 (en) * | 2006-03-14 | 2007-10-18 | Cozad Jenny L | Pulse oximeter sleeve |
| US8219172B2 (en) | 2006-03-17 | 2012-07-10 | Glt Acquisition Corp. | System and method for creating a stable optical interface |
| US7941199B2 (en) | 2006-05-15 | 2011-05-10 | Masimo Laboratories, Inc. | Sepsis monitor |
| US9176141B2 (en) | 2006-05-15 | 2015-11-03 | Cercacor Laboratories, Inc. | Physiological monitor calibration system |
| US8998809B2 (en) * | 2006-05-15 | 2015-04-07 | Cercacor Laboratories, Inc. | Systems and methods for calibrating minimally invasive and non-invasive physiological sensor devices |
| WO2007140478A2 (en) | 2006-05-31 | 2007-12-06 | Masimo Corporation | Respiratory monitoring |
| US10188348B2 (en) | 2006-06-05 | 2019-01-29 | Masimo Corporation | Parameter upgrade system |
| US8670777B2 (en) | 2006-09-08 | 2014-03-11 | Qualcomm Incorporated | Method and apparatus for fast other sector interference (OSI) adjustment |
| US8442572B2 (en) * | 2006-09-08 | 2013-05-14 | Qualcomm Incorporated | Method and apparatus for adjustments for delta-based power control in wireless communication systems |
| US8457707B2 (en) | 2006-09-20 | 2013-06-04 | Masimo Corporation | Congenital heart disease monitor |
| USD609193S1 (en) | 2007-10-12 | 2010-02-02 | Masimo Corporation | Connector assembly |
| US8315683B2 (en) | 2006-09-20 | 2012-11-20 | Masimo Corporation | Duo connector patient cable |
| USD614305S1 (en) | 2008-02-29 | 2010-04-20 | Masimo Corporation | Connector assembly |
| US8840549B2 (en) | 2006-09-22 | 2014-09-23 | Masimo Corporation | Modular patient monitor |
| US9161696B2 (en) | 2006-09-22 | 2015-10-20 | Masimo Corporation | Modular patient monitor |
| WO2008039968A2 (en) * | 2006-09-28 | 2008-04-03 | The Research Foundation Of State University Of New York | Apparatus, system, kit and method for heart mapping |
| US8255026B1 (en) | 2006-10-12 | 2012-08-28 | Masimo Corporation, Inc. | Patient monitor capable of monitoring the quality of attached probes and accessories |
| US9192329B2 (en) | 2006-10-12 | 2015-11-24 | Masimo Corporation | Variable mode pulse indicator |
| EP2073692B1 (en) | 2006-10-12 | 2017-07-26 | Masimo Corporation | Perfusion index smoothing |
| US7880626B2 (en) | 2006-10-12 | 2011-02-01 | Masimo Corporation | System and method for monitoring the life of a physiological sensor |
| US8265723B1 (en) | 2006-10-12 | 2012-09-11 | Cercacor Laboratories, Inc. | Oximeter probe off indicator defining probe off space |
| US20080094228A1 (en) * | 2006-10-12 | 2008-04-24 | Welch James P | Patient monitor using radio frequency identification tags |
| US9861305B1 (en) | 2006-10-12 | 2018-01-09 | Masimo Corporation | Method and apparatus for calibration to reduce coupling between signals in a measurement system |
| US8600467B2 (en) | 2006-11-29 | 2013-12-03 | Cercacor Laboratories, Inc. | Optical sensor including disposable and reusable elements |
| EP2096994B1 (en) | 2006-12-09 | 2018-10-03 | Masimo Corporation | Plethysmograph variability determination |
| US8852094B2 (en) | 2006-12-22 | 2014-10-07 | Masimo Corporation | Physiological parameter system |
| US7791155B2 (en) | 2006-12-22 | 2010-09-07 | Masimo Laboratories, Inc. | Detector shield |
| US8652060B2 (en) | 2007-01-20 | 2014-02-18 | Masimo Corporation | Perfusion trend indicator |
| US8781544B2 (en) | 2007-03-27 | 2014-07-15 | Cercacor Laboratories, Inc. | Multiple wavelength optical sensor |
| US8374665B2 (en) | 2007-04-21 | 2013-02-12 | Cercacor Laboratories, Inc. | Tissue profile wellness monitor |
| US8764671B2 (en) | 2007-06-28 | 2014-07-01 | Masimo Corporation | Disposable active pulse sensor |
| US8048040B2 (en) | 2007-09-13 | 2011-11-01 | Masimo Corporation | Fluid titration system |
| US8355766B2 (en) | 2007-10-12 | 2013-01-15 | Masimo Corporation | Ceramic emitter substrate |
| US8274360B2 (en) | 2007-10-12 | 2012-09-25 | Masimo Corporation | Systems and methods for storing, analyzing, and retrieving medical data |
| US8310336B2 (en) | 2008-10-10 | 2012-11-13 | Masimo Corporation | Systems and methods for storing, analyzing, retrieving and displaying streaming medical data |
| EP2227843B1 (en) | 2007-10-12 | 2019-03-06 | Masimo Corporation | Connector assembly |
| WO2009055012A2 (en) * | 2007-10-25 | 2009-04-30 | Andriy Tsupryk | Single photon spectrometer |
| US9717896B2 (en) | 2007-12-18 | 2017-08-01 | Gearbox, Llc | Treatment indications informed by a priori implant information |
| US8280484B2 (en) | 2007-12-18 | 2012-10-02 | The Invention Science Fund I, Llc | System, devices, and methods for detecting occlusions in a biological subject |
| US20090287120A1 (en) | 2007-12-18 | 2009-11-19 | Searete Llc, A Limited Liability Corporation Of The State Of Delaware | Circulatory monitoring systems and methods |
| US8636670B2 (en) | 2008-05-13 | 2014-01-28 | The Invention Science Fund I, Llc | Circulatory monitoring systems and methods |
| US9672471B2 (en) * | 2007-12-18 | 2017-06-06 | Gearbox Llc | Systems, devices, and methods for detecting occlusions in a biological subject including spectral learning |
| US8571617B2 (en) | 2008-03-04 | 2013-10-29 | Glt Acquisition Corp. | Flowometry in optical coherence tomography for analyte level estimation |
| JP5575752B2 (en) | 2008-05-02 | 2014-08-20 | マシモ コーポレイション | Monitor configuration system |
| EP2312995B1 (en) | 2008-05-05 | 2017-06-28 | Masimo Corporation | Pulse oximetry system with electrical decoupling circuitry |
| US9042967B2 (en) | 2008-05-20 | 2015-05-26 | University Health Network | Device and method for wound imaging and monitoring |
| USD621516S1 (en) | 2008-08-25 | 2010-08-10 | Masimo Laboratories, Inc. | Patient monitoring sensor |
| US8577431B2 (en) | 2008-07-03 | 2013-11-05 | Cercacor Laboratories, Inc. | Noise shielding for a noninvasive device |
| US8203438B2 (en) | 2008-07-29 | 2012-06-19 | Masimo Corporation | Alarm suspend system |
| US8203704B2 (en) | 2008-08-04 | 2012-06-19 | Cercacor Laboratories, Inc. | Multi-stream sensor for noninvasive measurement of blood constituents |
| SE532941C2 (en) | 2008-09-15 | 2010-05-18 | Phasein Ab | Gas sampling line for breathing gases |
| WO2010031070A2 (en) | 2008-09-15 | 2010-03-18 | Masimo Corporation | Patient monitor including multi-parameter graphical display |
| US8401602B2 (en) | 2008-10-13 | 2013-03-19 | Masimo Corporation | Secondary-emitter sensor position indicator |
| US8346330B2 (en) | 2008-10-13 | 2013-01-01 | Masimo Corporation | Reflection-detector sensor position indicator |
| US8771204B2 (en) | 2008-12-30 | 2014-07-08 | Masimo Corporation | Acoustic sensor assembly |
| US8588880B2 (en) | 2009-02-16 | 2013-11-19 | Masimo Corporation | Ear sensor |
| US10007758B2 (en) | 2009-03-04 | 2018-06-26 | Masimo Corporation | Medical monitoring system |
| US10032002B2 (en) | 2009-03-04 | 2018-07-24 | Masimo Corporation | Medical monitoring system |
| US9218454B2 (en) | 2009-03-04 | 2015-12-22 | Masimo Corporation | Medical monitoring system |
| US9323894B2 (en) | 2011-08-19 | 2016-04-26 | Masimo Corporation | Health care sanitation monitoring system |
| US8388353B2 (en) | 2009-03-11 | 2013-03-05 | Cercacor Laboratories, Inc. | Magnetic connector |
| US8897847B2 (en) | 2009-03-23 | 2014-11-25 | Masimo Corporation | Digit gauge for noninvasive optical sensor |
| US8989831B2 (en) | 2009-05-19 | 2015-03-24 | Masimo Corporation | Disposable components for reusable physiological sensor |
| US8571619B2 (en) | 2009-05-20 | 2013-10-29 | Masimo Corporation | Hemoglobin display and patient treatment |
| US8418524B2 (en) | 2009-06-12 | 2013-04-16 | Masimo Corporation | Non-invasive sensor calibration device |
| US8670811B2 (en) | 2009-06-30 | 2014-03-11 | Masimo Corporation | Pulse oximetry system for adjusting medical ventilation |
| US8471713B2 (en) | 2009-07-24 | 2013-06-25 | Cercacor Laboratories, Inc. | Interference detector for patient monitor |
| US8473020B2 (en) | 2009-07-29 | 2013-06-25 | Cercacor Laboratories, Inc. | Non-invasive physiological sensor cover |
| US8688183B2 (en) | 2009-09-03 | 2014-04-01 | Ceracor Laboratories, Inc. | Emitter driver for noninvasive patient monitor |
| US20110172498A1 (en) | 2009-09-14 | 2011-07-14 | Olsen Gregory A | Spot check monitor credit system |
| US9579039B2 (en) | 2011-01-10 | 2017-02-28 | Masimo Corporation | Non-invasive intravascular volume index monitor |
| US20110137297A1 (en) | 2009-09-17 | 2011-06-09 | Kiani Massi Joe E | Pharmacological management system |
| DE112010003689T5 (en) | 2009-09-17 | 2013-01-17 | Marcelo Lamego | Improved analyte monitoring using one or more accelerometers |
| US8571618B1 (en) | 2009-09-28 | 2013-10-29 | Cercacor Laboratories, Inc. | Adaptive calibration system for spectrophotometric measurements |
| US20110082711A1 (en) | 2009-10-06 | 2011-04-07 | Masimo Laboratories, Inc. | Personal digital assistant or organizer for monitoring glucose levels |
| US8790268B2 (en) | 2009-10-15 | 2014-07-29 | Masimo Corporation | Bidirectional physiological information display |
| US8821415B2 (en) | 2009-10-15 | 2014-09-02 | Masimo Corporation | Physiological acoustic monitoring system |
| US9106038B2 (en) | 2009-10-15 | 2015-08-11 | Masimo Corporation | Pulse oximetry system with low noise cable hub |
| US9066680B1 (en) | 2009-10-15 | 2015-06-30 | Masimo Corporation | System for determining confidence in respiratory rate measurements |
| EP3735899B1 (en) | 2009-10-15 | 2023-11-29 | Masimo Corporation | Acoustic respiratory monitoring sensor having multiple sensing elements |
| WO2011047216A2 (en) | 2009-10-15 | 2011-04-21 | Masimo Corporation | Physiological acoustic monitoring system |
| US9724016B1 (en) | 2009-10-16 | 2017-08-08 | Masimo Corp. | Respiration processor |
| US9839381B1 (en) | 2009-11-24 | 2017-12-12 | Cercacor Laboratories, Inc. | Physiological measurement system with automatic wavelength adjustment |
| DE112010004682T5 (en) | 2009-12-04 | 2013-03-28 | Masimo Corporation | Calibration for multi-level physiological monitors |
| US9153112B1 (en) | 2009-12-21 | 2015-10-06 | Masimo Corporation | Modular patient monitor |
| WO2011091059A1 (en) | 2010-01-19 | 2011-07-28 | Masimo Corporation | Wellness analysis system |
| GB2490832B (en) | 2010-03-01 | 2016-09-21 | Masimo Corp | Adaptive alarm system |
| WO2011112524A1 (en) | 2010-03-08 | 2011-09-15 | Masimo Corporation | Reprocessing of a physiological sensor |
| US9307928B1 (en) | 2010-03-30 | 2016-04-12 | Masimo Corporation | Plethysmographic respiration processor |
| US8712494B1 (en) | 2010-05-03 | 2014-04-29 | Masimo Corporation | Reflective non-invasive sensor |
| US9138180B1 (en) | 2010-05-03 | 2015-09-22 | Masimo Corporation | Sensor adapter cable |
| US8666468B1 (en) | 2010-05-06 | 2014-03-04 | Masimo Corporation | Patient monitor for determining microcirculation state |
| US9326712B1 (en) | 2010-06-02 | 2016-05-03 | Masimo Corporation | Opticoustic sensor |
| US8740792B1 (en) | 2010-07-12 | 2014-06-03 | Masimo Corporation | Patient monitor capable of accounting for environmental conditions |
| US9408542B1 (en) | 2010-07-22 | 2016-08-09 | Masimo Corporation | Non-invasive blood pressure measurement system |
| WO2012027613A1 (en) | 2010-08-26 | 2012-03-01 | Masimo Corporation | Blood pressure measurement system |
| US9775545B2 (en) | 2010-09-28 | 2017-10-03 | Masimo Corporation | Magnetic electrical connector for patient monitors |
| JP5710767B2 (en) | 2010-09-28 | 2015-04-30 | マシモ コーポレイション | Depth of consciousness monitor including oximeter |
| US9211095B1 (en) | 2010-10-13 | 2015-12-15 | Masimo Corporation | Physiological measurement logic engine |
| AU2011315951B2 (en) * | 2010-10-15 | 2015-03-19 | Lockheed Martin Corporation | Micro fluidic optic design |
| US8723677B1 (en) | 2010-10-20 | 2014-05-13 | Masimo Corporation | Patient safety system with automatically adjusting bed |
| US20120226117A1 (en) | 2010-12-01 | 2012-09-06 | Lamego Marcelo M | Handheld processing device including medical applications for minimally and non invasive glucose measurements |
| EP2673721A1 (en) | 2011-02-13 | 2013-12-18 | Masimo Corporation | Medical characterization system |
| US9066666B2 (en) | 2011-02-25 | 2015-06-30 | Cercacor Laboratories, Inc. | Patient monitor for monitoring microcirculation |
| US8830449B1 (en) | 2011-04-18 | 2014-09-09 | Cercacor Laboratories, Inc. | Blood analysis system |
| US9095316B2 (en) | 2011-04-20 | 2015-08-04 | Masimo Corporation | System for generating alarms based on alarm patterns |
| US9622692B2 (en) | 2011-05-16 | 2017-04-18 | Masimo Corporation | Personal health device |
| US9532722B2 (en) | 2011-06-21 | 2017-01-03 | Masimo Corporation | Patient monitoring system |
| US9986919B2 (en) | 2011-06-21 | 2018-06-05 | Masimo Corporation | Patient monitoring system |
| US9245668B1 (en) | 2011-06-29 | 2016-01-26 | Cercacor Laboratories, Inc. | Low noise cable providing communication between electronic sensor components and patient monitor |
| US11439329B2 (en) | 2011-07-13 | 2022-09-13 | Masimo Corporation | Multiple measurement mode in a physiological sensor |
| US9192351B1 (en) | 2011-07-22 | 2015-11-24 | Masimo Corporation | Acoustic respiratory monitoring sensor with probe-off detection |
| US8755872B1 (en) | 2011-07-28 | 2014-06-17 | Masimo Corporation | Patient monitoring system for indicating an abnormal condition |
| US9782077B2 (en) | 2011-08-17 | 2017-10-10 | Masimo Corporation | Modulated physiological sensor |
| WO2013056141A1 (en) | 2011-10-13 | 2013-04-18 | Masimo Corporation | Physiological acoustic monitoring system |
| US9943269B2 (en) | 2011-10-13 | 2018-04-17 | Masimo Corporation | System for displaying medical monitoring data |
| EP2766834B1 (en) | 2011-10-13 | 2022-04-20 | Masimo Corporation | Medical monitoring hub |
| US9808188B1 (en) | 2011-10-13 | 2017-11-07 | Masimo Corporation | Robust fractional saturation determination |
| US9778079B1 (en) | 2011-10-27 | 2017-10-03 | Masimo Corporation | Physiological monitor gauge panel |
| US9445759B1 (en) | 2011-12-22 | 2016-09-20 | Cercacor Laboratories, Inc. | Blood glucose calibration system |
| US11172890B2 (en) | 2012-01-04 | 2021-11-16 | Masimo Corporation | Automated condition screening and detection |
| US9392945B2 (en) | 2012-01-04 | 2016-07-19 | Masimo Corporation | Automated CCHD screening and detection |
| US9480435B2 (en) | 2012-02-09 | 2016-11-01 | Masimo Corporation | Configurable patient monitoring system |
| US10149616B2 (en) | 2012-02-09 | 2018-12-11 | Masimo Corporation | Wireless patient monitoring device |
| US10307111B2 (en) | 2012-02-09 | 2019-06-04 | Masimo Corporation | Patient position detection system |
| EP2845086B1 (en) | 2012-03-25 | 2021-12-22 | Masimo Corporation | Physiological monitor touchscreen interface |
| EP4268712A3 (en) | 2012-04-17 | 2024-01-17 | Masimo Corporation | Hypersaturation index |
| US20130327956A1 (en) * | 2012-06-07 | 2013-12-12 | Achrolux Inc. | Phosphor layer detection system |
| WO2013184965A1 (en) | 2012-06-07 | 2013-12-12 | Masimo Corporation | Depth of consciousness monitor |
| US9697928B2 (en) | 2012-08-01 | 2017-07-04 | Masimo Corporation | Automated assembly sensor cable |
| US10827961B1 (en) | 2012-08-29 | 2020-11-10 | Masimo Corporation | Physiological measurement calibration |
| US9877650B2 (en) | 2012-09-20 | 2018-01-30 | Masimo Corporation | Physiological monitor with mobile computing device connectivity |
| US9955937B2 (en) | 2012-09-20 | 2018-05-01 | Masimo Corporation | Acoustic patient sensor coupler |
| US9749232B2 (en) | 2012-09-20 | 2017-08-29 | Masimo Corporation | Intelligent medical network edge router |
| US9717458B2 (en) | 2012-10-20 | 2017-08-01 | Masimo Corporation | Magnetic-flap optical sensor |
| US9560996B2 (en) | 2012-10-30 | 2017-02-07 | Masimo Corporation | Universal medical system |
| US9787568B2 (en) | 2012-11-05 | 2017-10-10 | Cercacor Laboratories, Inc. | Physiological test credit method |
| US9750461B1 (en) | 2013-01-02 | 2017-09-05 | Masimo Corporation | Acoustic respiratory monitoring sensor with probe-off detection |
| US9724025B1 (en) | 2013-01-16 | 2017-08-08 | Masimo Corporation | Active-pulse blood analysis system |
| US9750442B2 (en) | 2013-03-09 | 2017-09-05 | Masimo Corporation | Physiological status monitor |
| US9965946B2 (en) | 2013-03-13 | 2018-05-08 | Masimo Corporation | Systems and methods for monitoring a patient health network |
| US10441181B1 (en) | 2013-03-13 | 2019-10-15 | Masimo Corporation | Acoustic pulse and respiration monitoring system |
| US9936917B2 (en) | 2013-03-14 | 2018-04-10 | Masimo Laboratories, Inc. | Patient monitor placement indicator |
| US9986952B2 (en) | 2013-03-14 | 2018-06-05 | Masimo Corporation | Heart sound simulator |
| US9474474B2 (en) | 2013-03-14 | 2016-10-25 | Masimo Corporation | Patient monitor as a minimally invasive glucometer |
| US10456038B2 (en) | 2013-03-15 | 2019-10-29 | Cercacor Laboratories, Inc. | Cloud-based physiological monitoring system |
| DE102013008003B4 (en) | 2013-05-08 | 2015-03-19 | Freshdetect Gmbh | Measuring device for measuring a surface covering on a measuring object, in particular on a food, and its use |
| US9891079B2 (en) | 2013-07-17 | 2018-02-13 | Masimo Corporation | Pulser with double-bearing position encoder for non-invasive physiological monitoring |
| WO2015020911A2 (en) | 2013-08-05 | 2015-02-12 | Cercacor Laboratories, Inc. | Blood pressure monitor with valve-chamber assembly |
| WO2015038683A2 (en) | 2013-09-12 | 2015-03-19 | Cercacor Laboratories, Inc. | Medical device management system |
| US10010276B2 (en) | 2013-10-07 | 2018-07-03 | Masimo Corporation | Regional oximetry user interface |
| US11147518B1 (en) | 2013-10-07 | 2021-10-19 | Masimo Corporation | Regional oximetry signal processor |
| US10828007B1 (en) | 2013-10-11 | 2020-11-10 | Masimo Corporation | Acoustic sensor with attachment portion |
| US10832818B2 (en) | 2013-10-11 | 2020-11-10 | Masimo Corporation | Alarm notification system |
| US10279247B2 (en) | 2013-12-13 | 2019-05-07 | Masimo Corporation | Avatar-incentive healthcare therapy |
| US11259745B2 (en) | 2014-01-28 | 2022-03-01 | Masimo Corporation | Autonomous drug delivery system |
| US10086138B1 (en) | 2014-01-28 | 2018-10-02 | Masimo Corporation | Autonomous drug delivery system |
| US10532174B2 (en) | 2014-02-21 | 2020-01-14 | Masimo Corporation | Assistive capnography device |
| US9924897B1 (en) | 2014-06-12 | 2018-03-27 | Masimo Corporation | Heated reprocessing of physiological sensors |
| US10123729B2 (en) | 2014-06-13 | 2018-11-13 | Nanthealth, Inc. | Alarm fatigue management systems and methods |
| US10231670B2 (en) | 2014-06-19 | 2019-03-19 | Masimo Corporation | Proximity sensor in pulse oximeter |
| PT3171765T (en) | 2014-07-24 | 2021-10-27 | Univ Health Network | Collection and analysis of data for diagnostic purposes |
| US10111591B2 (en) | 2014-08-26 | 2018-10-30 | Nanthealth, Inc. | Real-time monitoring systems and methods in a healthcare environment |
| WO2016036985A1 (en) | 2014-09-04 | 2016-03-10 | Masimo Corportion | Total hemoglobin index system |
| US10383520B2 (en) | 2014-09-18 | 2019-08-20 | Masimo Semiconductor, Inc. | Enhanced visible near-infrared photodiode and non-invasive physiological sensor |
| WO2016057553A1 (en) | 2014-10-07 | 2016-04-14 | Masimo Corporation | Modular physiological sensors |
| KR102575058B1 (en) | 2015-01-23 | 2023-09-05 | 마시모 스웨덴 에이비 | Nasal/Oral Cannula Systems and Manufacturing |
| US10568553B2 (en) | 2015-02-06 | 2020-02-25 | Masimo Corporation | Soft boot pulse oximetry sensor |
| USD755392S1 (en) | 2015-02-06 | 2016-05-03 | Masimo Corporation | Pulse oximetry sensor |
| KR20230164226A (en) | 2015-02-06 | 2023-12-01 | 마시모 코오퍼레이션 | Connector assembly with pogo pins for use with medical sensors |
| BR112017016302B1 (en) | 2015-02-06 | 2022-12-06 | Masimo Corporation | PHYSIOLOGICAL SENSOR MANUFACTURING METHOD WITH EFFICIENT FLEXIBLE CIRCUIT |
| US10524738B2 (en) | 2015-05-04 | 2020-01-07 | Cercacor Laboratories, Inc. | Noninvasive sensor system with visual infographic display |
| WO2016191307A1 (en) | 2015-05-22 | 2016-12-01 | Cercacor Laboratories, Inc. | Non-invasive optical physiological differential pathlength sensor |
| JP6505260B2 (en) * | 2015-06-30 | 2019-04-24 | アイメック・ヴェーゼットウェーＩｍｅｃ Ｖｚｗ | Use of a radiation carrier in a radiation carrier and an optical sensor |
| US10448871B2 (en) | 2015-07-02 | 2019-10-22 | Masimo Corporation | Advanced pulse oximetry sensor |
| AU2016304884B2 (en) | 2015-08-11 | 2021-01-28 | Masimo Corporation | Medical monitoring analysis and replay including indicia responsive to light attenuated by body tissue |
| US10736518B2 (en) | 2015-08-31 | 2020-08-11 | Masimo Corporation | Systems and methods to monitor repositioning of a patient |
| US11504066B1 (en) | 2015-09-04 | 2022-11-22 | Cercacor Laboratories, Inc. | Low-noise sensor system |
| US11679579B2 (en) | 2015-12-17 | 2023-06-20 | Masimo Corporation | Varnish-coated release liner |
| US10993662B2 (en) | 2016-03-04 | 2021-05-04 | Masimo Corporation | Nose sensor |
| US10537285B2 (en) | 2016-03-04 | 2020-01-21 | Masimo Corporation | Nose sensor |
| US11191484B2 (en) | 2016-04-29 | 2021-12-07 | Masimo Corporation | Optical sensor tape |
| US10608817B2 (en) | 2016-07-06 | 2020-03-31 | Masimo Corporation | Secure and zero knowledge data sharing for cloud applications |
| US10617302B2 (en) | 2016-07-07 | 2020-04-14 | Masimo Corporation | Wearable pulse oximeter and respiration monitor |
| DE102016116377A1 (en) | 2016-09-01 | 2018-03-01 | Rheinisch-Westfälisch Technische Hochschule (RWTH) Aachen | Method and device for detecting process parameters in liquid cultures |
| WO2018071715A1 (en) | 2016-10-13 | 2018-04-19 | Masimo Corporation | Systems and methods for patient fall detection |
| US11504058B1 (en) | 2016-12-02 | 2022-11-22 | Masimo Corporation | Multi-site noninvasive measurement of a physiological parameter |
| WO2018119239A1 (en) | 2016-12-22 | 2018-06-28 | Cercacor Laboratories, Inc | Methods and devices for detecting intensity of light with translucent detector |
| US10721785B2 (en) | 2017-01-18 | 2020-07-21 | Masimo Corporation | Patient-worn wireless physiological sensor with pairing functionality |
| WO2018156648A1 (en) | 2017-02-24 | 2018-08-30 | Masimo Corporation | Managing dynamic licenses for physiological parameters in a patient monitoring environment |
| US10388120B2 (en) | 2017-02-24 | 2019-08-20 | Masimo Corporation | Localized projection of audible noises in medical settings |
| US10327713B2 (en) | 2017-02-24 | 2019-06-25 | Masimo Corporation | Modular multi-parameter patient monitoring device |
| WO2018156809A1 (en) | 2017-02-24 | 2018-08-30 | Masimo Corporation | Augmented reality system for displaying patient data |
| US11086609B2 (en) | 2017-02-24 | 2021-08-10 | Masimo Corporation | Medical monitoring hub |
| KR102567007B1 (en) | 2017-02-24 | 2023-08-16 | 마시모 코오퍼레이션 | Medical monitoring data display system |
| CN110891486A (en) | 2017-03-10 | 2020-03-17 | 梅西莫股份有限公司 | Pneumonia screening instrument |
| WO2018194992A1 (en) | 2017-04-18 | 2018-10-25 | Masimo Corporation | Nose sensor |
| US10918281B2 (en) | 2017-04-26 | 2021-02-16 | Masimo Corporation | Medical monitoring device having multiple configurations |
| USD835285S1 (en) | 2017-04-28 | 2018-12-04 | Masimo Corporation | Medical monitoring device |
| USD835284S1 (en) | 2017-04-28 | 2018-12-04 | Masimo Corporation | Medical monitoring device |
| JP7278220B2 (en) | 2017-04-28 | 2023-05-19 | マシモ・コーポレイション | Spot check measurement system |
| USD835282S1 (en) | 2017-04-28 | 2018-12-04 | Masimo Corporation | Medical monitoring device |
| USD835283S1 (en) | 2017-04-28 | 2018-12-04 | Masimo Corporation | Medical monitoring device |
| CN117373636A (en) | 2017-05-08 | 2024-01-09 | 梅西莫股份有限公司 | System for pairing a medical system with a network controller using an adapter |
| US11026604B2 (en) | 2017-07-13 | 2021-06-08 | Cercacor Laboratories, Inc. | Medical monitoring device for harmonizing physiological measurements |
| US10637181B2 (en) | 2017-08-15 | 2020-04-28 | Masimo Corporation | Water resistant connector for noninvasive patient monitor |
| USD906970S1 (en) | 2017-08-15 | 2021-01-05 | Masimo Corporation | Connector |
| USD890708S1 (en) | 2017-08-15 | 2020-07-21 | Masimo Corporation | Connector |
| CN111212599A (en) | 2017-10-19 | 2020-05-29 | 迈心诺公司 | Display arrangement for medical monitoring system |
| EP3703566B1 (en) | 2017-10-31 | 2023-07-26 | Masimo Corporation | System for displaying oxygen state indications |
| USD925597S1 (en) | 2017-10-31 | 2021-07-20 | Masimo Corporation | Display screen or portion thereof with graphical user interface |
| US11766198B2 (en) | 2018-02-02 | 2023-09-26 | Cercacor Laboratories, Inc. | Limb-worn patient monitoring device |
| EP3782165A1 (en) | 2018-04-19 | 2021-02-24 | Masimo Corporation | Mobile patient alarm display |
| US11883129B2 (en) | 2018-04-24 | 2024-01-30 | Cercacor Laboratories, Inc. | Easy insert finger sensor for transmission based spectroscopy sensor |
| US11627919B2 (en) | 2018-06-06 | 2023-04-18 | Masimo Corporation | Opioid overdose monitoring |
| US10779098B2 (en) | 2018-07-10 | 2020-09-15 | Masimo Corporation | Patient monitor alarm speaker analyzer |
| US11872156B2 (en) | 2018-08-22 | 2024-01-16 | Masimo Corporation | Core body temperature measurement |
| USD917550S1 (en) | 2018-10-11 | 2021-04-27 | Masimo Corporation | Display screen or portion thereof with a graphical user interface |
| USD917564S1 (en) | 2018-10-11 | 2021-04-27 | Masimo Corporation | Display screen or portion thereof with graphical user interface |
| USD998630S1 (en) | 2018-10-11 | 2023-09-12 | Masimo Corporation | Display screen or portion thereof with a graphical user interface |
| USD998631S1 (en) | 2018-10-11 | 2023-09-12 | Masimo Corporation | Display screen or portion thereof with a graphical user interface |
| US11406286B2 (en) | 2018-10-11 | 2022-08-09 | Masimo Corporation | Patient monitoring device with improved user interface |
| USD999246S1 (en) | 2018-10-11 | 2023-09-19 | Masimo Corporation | Display screen or portion thereof with a graphical user interface |
| USD916135S1 (en) | 2018-10-11 | 2021-04-13 | Masimo Corporation | Display screen or portion thereof with a graphical user interface |
| US11389093B2 (en) | 2018-10-11 | 2022-07-19 | Masimo Corporation | Low noise oximetry cable |
| BR112021006841A2 (en) | 2018-10-11 | 2021-07-13 | Masimo Corporation | non-invasive physiological sensor assembly and method of fabricating a connector assembly for a non-invasive sensor assembly |
| US11464410B2 (en) | 2018-10-12 | 2022-10-11 | Masimo Corporation | Medical systems and methods |
| MX2021004064A (en) | 2018-10-12 | 2021-06-23 | Masimo Corp | System for transmission of sensor data using dual communication protocol. |
| USD897098S1 (en) | 2018-10-12 | 2020-09-29 | Masimo Corporation | Card holder set |
| US11684296B2 (en) | 2018-12-21 | 2023-06-27 | Cercacor Laboratories, Inc. | Noninvasive physiological sensor |
| US20200329993A1 (en) | 2019-04-17 | 2020-10-22 | Masimo Corporation | Electrocardiogram device |
| CN110221051B (en) * | 2019-05-23 | 2021-06-22 | 南京航空航天大学 | Dual-wavelength dual-scale nano-drug in-vivo monitoring system and time sequence control method |
| USD917704S1 (en) | 2019-08-16 | 2021-04-27 | Masimo Corporation | Patient monitor |
| USD985498S1 (en) | 2019-08-16 | 2023-05-09 | Masimo Corporation | Connector |
| USD919100S1 (en) | 2019-08-16 | 2021-05-11 | Masimo Corporation | Holder for a patient monitor |
| USD919094S1 (en) | 2019-08-16 | 2021-05-11 | Masimo Corporation | Blood pressure device |
| USD921202S1 (en) | 2019-08-16 | 2021-06-01 | Masimo Corporation | Holder for a blood pressure device |
| US11832940B2 (en) | 2019-08-27 | 2023-12-05 | Cercacor Laboratories, Inc. | Non-invasive medical monitoring device for blood analyte measurements |
| USD927699S1 (en) | 2019-10-18 | 2021-08-10 | Masimo Corporation | Electrode pad |
| KR20220083771A (en) | 2019-10-18 | 2022-06-20 | 마시모 코오퍼레이션 | Display layouts and interactive objects for patient monitoring |
| BR112022007593A2 (en) | 2019-10-25 | 2022-08-23 | Cercacor Lab Inc | INDICATOR COMPOUNDS, DEVICES INCLUDING INDICATOR COMPOUNDS AND MANUFACTURING AND USE METHODS |
| US11879960B2 (en) | 2020-02-13 | 2024-01-23 | Masimo Corporation | System and method for monitoring clinical activities |
| US11721105B2 (en) | 2020-02-13 | 2023-08-08 | Masimo Corporation | System and method for monitoring clinical activities |
| US20210290080A1 (en) | 2020-03-20 | 2021-09-23 | Masimo Corporation | Remote patient management and monitoring systems and methods |
| USD933232S1 (en) | 2020-05-11 | 2021-10-12 | Masimo Corporation | Blood pressure monitor |
| USD979516S1 (en) | 2020-05-11 | 2023-02-28 | Masimo Corporation | Connector |
| USD974193S1 (en) | 2020-07-27 | 2023-01-03 | Masimo Corporation | Wearable temperature measurement device |
| USD980091S1 (en) | 2020-07-27 | 2023-03-07 | Masimo Corporation | Wearable temperature measurement device |
| USD946596S1 (en) | 2020-09-30 | 2022-03-22 | Masimo Corporation | Display screen or portion thereof with graphical user interface |
| USD946597S1 (en) | 2020-09-30 | 2022-03-22 | Masimo Corporation | Display screen or portion thereof with graphical user interface |
| USD946598S1 (en) | 2020-09-30 | 2022-03-22 | Masimo Corporation | Display screen or portion thereof with graphical user interface |
| USD997365S1 (en) | 2021-06-24 | 2023-08-29 | Masimo Corporation | Physiological nose sensor |
| USD1000975S1 (en) | 2021-09-22 | 2023-10-10 | Masimo Corporation | Wearable temperature measurement device |
Family Cites Families (35)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3652855A (en) * | 1969-05-26 | 1972-03-28 | John Armin Mcintyre | Radiation image amplifier and display comprising a fiber optic matrix for detecting and coding the radiation image pattern |
| US4505583A (en) | 1981-04-10 | 1985-03-19 | Masaaki Konomi | Spectroscopic analyzer system for examining intravital tissue |
| US5106387A (en) * | 1985-03-22 | 1992-04-21 | Massachusetts Institute Of Technology | Method for spectroscopic diagnosis of tissue |
| KR0148748B1 (en) | 1988-09-16 | 1998-08-17 | 장 크라메르, 한스 루돌프 하우스 | A multiphase cyclosporin composition |
| US5201318A (en) * | 1989-04-24 | 1993-04-13 | Rava Richard P | Contour mapping of spectral diagnostics |
| US5569591A (en) | 1990-08-03 | 1996-10-29 | University College Of Wales Aberystwyth | Analytical or monitoring apparatus and method |
| US5303026A (en) | 1991-02-26 | 1994-04-12 | The Regents Of The University Of California Los Alamos National Laboratory | Apparatus and method for spectroscopic analysis of scattering media |
| CA2104960C (en) | 1991-02-26 | 2005-04-05 | Richard P. Rava | Systems and methods of molecular spectroscopy to provide for the diagnosis of tissue |
| US5370114A (en) | 1992-03-12 | 1994-12-06 | Wong; Jacob Y. | Non-invasive blood chemistry measurement by stimulated infrared relaxation emission |
| IL107396A (en) | 1992-11-09 | 1997-02-18 | Boehringer Mannheim Gmbh | Method and apparatus for analytical determination of glucose in a biological matrix |
| AU6186494A (en) | 1993-05-07 | 1994-11-10 | Diasense, Inc. | Non-invasive determination of analyte concentration using non-continuous radiation |
| AU7828694A (en) | 1993-08-24 | 1995-03-22 | Mark R. Robinson | A robust accurate non-invasive analyte monitor |
| US5491344A (en) * | 1993-12-01 | 1996-02-13 | Tufts University | Method and system for examining the composition of a fluid or solid sample using fluorescence and/or absorption spectroscopy |
| US5599717A (en) | 1994-09-02 | 1997-02-04 | Martin Marietta Energy Systems, Inc. | Advanced synchronous luminescence system |
| US5579773A (en) * | 1994-09-30 | 1996-12-03 | Martin Marietta Energy Systems, Inc. | Laser-induced differential normalized fluorescence method for cancer diagnosis |
| US5697373A (en) * | 1995-03-14 | 1997-12-16 | Board Of Regents, The University Of Texas System | Optical method and apparatus for the diagnosis of cervical precancers using raman and fluorescence spectroscopies |
| US6258576B1 (en) | 1996-06-19 | 2001-07-10 | Board Of Regents, The University Of Texas System | Diagnostic method and apparatus for cervical squamous intraepithelial lesions in vitro and in vivo using fluorescence spectroscopy |
| IL113333A (en) | 1995-04-11 | 2001-01-28 | Yoav Paltieli | Optical-fiber type endoscope |
| WO1997008538A1 (en) * | 1995-08-24 | 1997-03-06 | Purdue Research Foundation | Fluorescence lifetime-based imaging and spectroscopy in tissues and other random media |
| US6240309B1 (en) * | 1995-10-06 | 2001-05-29 | Hitachi, Ltd. | Optical measurement instrument for living body |
| US6232609B1 (en) | 1995-12-01 | 2001-05-15 | Cedars-Sinai Medical Center | Glucose monitoring apparatus and method using laser-induced emission spectroscopy |
| US5725480A (en) | 1996-03-06 | 1998-03-10 | Abbott Laboratories | Non-invasive calibration and categorization of individuals for subsequent non-invasive detection of biological compounds |
| EP0923335B1 (en) | 1996-07-08 | 2006-08-23 | Animas Corporation | Implantable sensor and system for in vivo measurement and control of fluid constituent levels |
| US5876339A (en) * | 1997-01-09 | 1999-03-02 | Lemire; Robert | Apparatus for optical breast imaging |
| EP1011426A1 (en) | 1997-02-26 | 2000-06-28 | Diasense, Inc. | Individual calibration of blood glucose for supporting noninvasive self-monitoring blood glucose |
| US6124597A (en) | 1997-07-07 | 2000-09-26 | Cedars-Sinai Medical Center | Method and devices for laser induced fluorescence attenuation spectroscopy |
| JP3758824B2 (en) | 1997-08-06 | 2006-03-22 | 倉敷紡績株式会社 | Biological pressure stabilization device |
| ES2281143T3 (en) | 1997-11-12 | 2007-09-16 | Lightouch Medical, Inc. | METHOD FOR THE NON-INVASIVE MEASUREMENT OF AN ANALYTE. |
| WO1999047041A1 (en) * | 1998-03-19 | 1999-09-23 | Board Of Regents, The University Of Texas System | Fiber-optic confocal imaging apparatus and methods of use |
| US6505059B1 (en) | 1998-04-06 | 2003-01-07 | The General Hospital Corporation | Non-invasive tissue glucose level monitoring |
| JP2002510515A (en) | 1998-04-06 | 2002-04-09 | ザ・ジェネラル・ホスピタル・コーポレイション | Non-invasive tissue glucose level monitoring |
| US6571118B1 (en) * | 1998-05-04 | 2003-05-27 | Board Of Regents, The University Of Texas System | Combined fluorescence and reflectance spectroscopy |
| US6377842B1 (en) * | 1998-09-22 | 2002-04-23 | Aurora Optics, Inc. | Method for quantitative measurement of fluorescent and phosphorescent drugs within tissue utilizing a fiber optic probe |
| US6157041A (en) | 1998-10-13 | 2000-12-05 | Rio Grande Medical Technologies, Inc. | Methods and apparatus for tailoring spectroscopic calibration models |
| US6405065B1 (en) | 1999-01-22 | 2002-06-11 | Instrumentation Metrics, Inc. | Non-invasive in vivo tissue classification using near-infrared measurements |
-
2001
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- 2001-02-20 AU AU2001237066A patent/AU2001237066A1/en not_active Abandoned
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- 2001-02-20 WO PCT/US2001/005321 patent/WO2001060247A1/en not_active Application Discontinuation
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