CA2400172A1 - Nanocapsule encapsulation system and method - Google Patents

Nanocapsule encapsulation system and method Download PDF

Info

Publication number
CA2400172A1
CA2400172A1 CA002400172A CA2400172A CA2400172A1 CA 2400172 A1 CA2400172 A1 CA 2400172A1 CA 002400172 A CA002400172 A CA 002400172A CA 2400172 A CA2400172 A CA 2400172A CA 2400172 A1 CA2400172 A1 CA 2400172A1
Authority
CA
Canada
Prior art keywords
nanocapsule
surfactant
component
aqueous composition
stabilized
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA002400172A
Other languages
French (fr)
Other versions
CA2400172C (en
Inventor
Gretchen M. Unger
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
GeneSegues Inc
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2400172A1 publication Critical patent/CA2400172A1/en
Application granted granted Critical
Publication of CA2400172C publication Critical patent/CA2400172C/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J13/00—Colloid chemistry, e.g. the production of colloidal materials or their solutions, not otherwise provided for; Making microcapsules or microballoons
    • B01J13/02—Making microcapsules or microballoons
    • B01J13/06—Making microcapsules or microballoons by phase separation
    • B01J13/08—Simple coacervation, i.e. addition of highly hydrophilic material
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
    • A61K9/1075—Microemulsions or submicron emulsions; Preconcentrates or solids thereof; Micelles, e.g. made of phospholipids or block copolymers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/51—Nanocapsules; Nanoparticles
    • A61K9/5107—Excipients; Inactive ingredients
    • A61K9/513—Organic macromolecular compounds; Dendrimers
    • A61K9/5138—Organic macromolecular compounds; Dendrimers obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/51—Nanocapsules; Nanoparticles
    • A61K9/5107—Excipients; Inactive ingredients
    • A61K9/513—Organic macromolecular compounds; Dendrimers
    • A61K9/5161—Polysaccharides, e.g. alginate, chitosan, cellulose derivatives; Cyclodextrin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/51—Nanocapsules; Nanoparticles
    • A61K9/5192—Processes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J13/00—Colloid chemistry, e.g. the production of colloidal materials or their solutions, not otherwise provided for; Making microcapsules or microballoons
    • B01J13/02—Making microcapsules or microballoons
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S977/00—Nanotechnology
    • Y10S977/70—Nanostructure
    • Y10S977/773—Nanoparticle, i.e. structure having three dimensions of 100 nm or less
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S977/00—Nanotechnology
    • Y10S977/70—Nanostructure
    • Y10S977/788—Of specified organic or carbon-based composition
    • Y10S977/795—Composed of biological material
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S977/00—Nanotechnology
    • Y10S977/84—Manufacture, treatment, or detection of nanostructure
    • Y10S977/895—Manufacture, treatment, or detection of nanostructure having step or means utilizing chemical property
    • Y10S977/896—Chemical synthesis, e.g. chemical bonding or breaking
    • Y10S977/897—Polymerization
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S977/00—Nanotechnology
    • Y10S977/902—Specified use of nanostructure
    • Y10S977/904—Specified use of nanostructure for medical, immunological, body treatment, or diagnosis
    • Y10S977/915—Therapeutic or pharmaceutical composition
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S977/00—Nanotechnology
    • Y10S977/902—Specified use of nanostructure
    • Y10S977/904—Specified use of nanostructure for medical, immunological, body treatment, or diagnosis
    • Y10S977/92—Detection of biochemical

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Epidemiology (AREA)
  • Nanotechnology (AREA)
  • Dispersion Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Optics & Photonics (AREA)
  • Biomedical Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Manufacturing Of Micro-Capsules (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

The present invention generally relates to nanocapsules and methods of preparing these nanocapsules. The present invention includes a method of forming a surfactant micelle and dispersing the surfactant micelle into an aqueous composition having a hydrophilic polymer to form a stabilized dispersion of surfactant micelles.
The method further includes mechanically forming droplets of the stabilized dispersion of surfactant micelles, precipitating the hydrophilic polymer to form precipitated nanocapsules, incubating the nanocapsules to reduce a diameter of the nanocapsules, and filtering or centrifuging the nanocapsules.

Claims (38)

1. A method of forming a dispersion of micelles, the method comprising:
forming a surfactant micelle, wherein the surfactant micelle comprises:
a surfactant coating a surface of a bioactive component to form a surfactant micelle, wherein the surfactant molecule has an HLB value of less than about 6.0 units; and dispersing the surfactant micelle into an aqueous composition, wherein the aqueous composition comprises a hydrophilic polymer, wherein the hydrophilic polymer coats a surface of the surfactant micelle to form the dispersion comprising the surfactant micelle having a diameter of less than about 50 nanometers.
2. The method of claim 1 wherein the surfactant molecule is a non-ionic surfactant.
3. The method of claim 1 and further including precipitating the hydrophilic polymer of the surfactant micelle to form a first nanocapsule having a first diameter.
4. The method of claim 2 wherein the bioactive component is separate from the hydrophilic polymer of the nanocapsule.
5. The method of claim 2 and further including incubating the first nanocapsule to form a second nanocapsule having a second diameter, wherein the second diameter is less than the first diameter of the first nanocapsule.

57.1
6. The method of claim 5 wherein incubating the first nanocapsule comprises immersing the first nanocapsute in the aqueous composition that includes a solute.
7. The method of claim 1 wherein the bioactive component is a hydrophilic component.
8. The method of claim 1 wherein the bioactive component is a polynucleotide or a polypeptide.
9. A method of forming a dispersion of surfactant micelles, the method comprising:
dispersing surfactant molecules into a first hydrophilic composition, the first hydrophilic composition comprising a hydrophilic bioactive component, wherein the surfactant molecules have an HLB value of less than about 5.0 units, and wherein the surfactant molecules form a shell around the hydrophilic bioactive component to form a dispersion of surfactant micelles;
adding a biocompatible hydrophilic polymer to the dispersion of surfactant micelles; and wherein the biocompatible hydrophilic polymer is effective to stabilize the dispersion.
10. The method of claim 9 wherein the biocompatible hydrophilic polymer forms a shell around the surfactant micelle.
11. A method of forming a nanocapsule, the method comprising:
dispersing a surfactant molecule into a first aqueous composition comprising a hydrophilic bioactive component, wherein the surfactant molecule has an HLB value of less than about 5.0 units, and wherein the surfactant molecule is adsorbed onto a surface of the hydrophilic component to form a surfactant micelle;
adding a biocompatible polymer to the first aqueous composition to form a stabilized aqueous composition comprising a plurality of stabilized surfactant micelles; and solidifying the stabilized surfactant micelles by dispersing the stabilized surfactant micelles into a second aqueous composition containing a solute for a time that is effective 58.1 to form a first nanocapsule having a first diameter.
12. The method of claim 11 wherein the surfactant molecule has a critical micelle concentration of less than about 200 µM.
13. The method of claim 11 and further including dispersing the surfactant molecule into a biocompatible oil prior to dispersing the surfactant molecule into the first aqueous composition.
14. The method of claim 11 wherein the biocompatible polymer is effective to form a shell around the surfactant micelle.
15. The method of claim 11 wherein the surfactant molecule is at a concentration of less than about 500 parts per million.
16. The method of claim 11 wherein dispersing the stabilized surfactant micelle comprises dispersing droplets of the stabilized surfactant micelle into the second aqueous composition.
17. The method of claim 11 wherein the hydrophilic bioactive component is condensed.
18. A method of producing a nanocapsule, the method comprising:
condensing a bioactive component in a first aqueous composition to form a condensed bioactive component;
dispersing surfactant molecules into the first aqueous composition, wherein the surfactant molecules have an HLB value of less than about 5.0 units, and wherein the surfactant molecules are adsorbed onto a surface of the condensed bioactive component to form a plurality of surfactant micelles;
coating the surfactant micelles with a biocompatible polymer to form a plurality of stabilized surfactant micelles;
dispersing the stabilized surfactant micelles into a second aqueous composition comprising a solute to form a nanocapsule having a first diameter; and wherein the bioactive component is not entangled in the biocompatible polymer of the nanocapsule.
19. The method of claim 18 wherein the biocompatible polymer is an iontophoretic polymer.
20. The method of claim 18 and further including incubating the nanocapsule to form a second nanocapsule having a second diameter, wherein the 59.1 second diameter is less than the first diameter.
21. A method of preparing a nanocapsule, the method comprising:
forming a hydrophobic composition, wherein the hydrophobic composition comprises a surfactant molecule adsorbed onto a surface of a hydrophobic component, and wherein the surfactant molecule has an HLB value of less than about 5.0 units;
adding a biocompatible polymer to the hydrophobic composition to form a stabilized composition, wherein the biocompatible polymer is effective to form a shell around the surfactant molecule; and dispersing the stabilized composition into an aqueous composition to form a nanocapsule.
22. The method of claim 21 wherein the biocompatible polymer is a hydrophilic polymer.
23. The method of claim 21 wherein the biocompatible polymer is capable of iontophoretic exchange.
24. The method of claim 21 wherein the hydrophobic composition further includes a water-miscible solvent.
25. The method of claim 21 and further including precipitating the nanocapsule by incubating the nanocapsule in the aqueous composition comprising a solute.
26. The method of claim 25 wherein incubating the nanocapsule is effective to reduce a diameter of the nanocapsule.
27. The method of claim 21 wherein dispersing the stabilized 60.1 composition comprises:
mechanically forming a plurality of droplets of the stabilized composition; and dispersing the plurality of droplets into the aqueous composition.
28. The method of claim 21 wherein the surfactant is 2, 4, 7, 9-tetramethyl-5-decyn-4, 7-diol, molecules containing an acetylenic diol portion, or blends of 2, 4, 7, 9-tetramethyl-5-decyn-4, 7-diol.
29. The method of claim 21 wherein the hydrophobic component is not entangled or embedded in the biocompatible polymer.
30. The method of claim 21 and further including filtering the nanocapsule.
31. The method of claim 22 and further including centrifuging the nanocapsule.
32. The method of claim 21 and further including adding the nanocapsules into a solid dosage form.
33. The method of claim 32 wherein the solid dosage form is selected from the group consisting of granules, tablets, pellets, films and coatings.
34. A method for transducing genetic material, the method comprising:
applying a plurality of nanocapsules comprising a polynucleotide prepared by the method of claim 1 to a plurality of cells; and transducing the cells by releasing the polynucleotide from a core of the nanocapsules within the cells.
35. A method for transducing genetic material, the method comprising:
delivering a plurality of nanocapsules comprising a polynucleotide prepared by the method of claim 1 to a patient.
36. The method of claim 35 wherein delivering comprises oral, intravenous, subcutaneous, intraperitoneal, intrathecal, intramuscular, inhalation, topical, transdermal, suppository, pessary, intra urethral, intraportal, intraocular, transtympanic, intrahepatic, intra-arterial, intraocular, intrathecal, transmucosal, buccal or any combination of any of these.

61.1
37. The method of claim 35 wherein the polynucleotide is released from a core of the nanocapsule.
38. A nanocapsule prepared by the method of claim 11.

40. A method of forming a nanocapsule matrix, the method comprising:
combining a plurality of nanocapsules, a binder and an excipient to form a nanocapsule matrix, wherein the nanocapsule matrix is capable of releasing the nanocapsules.

41. The method of claim 40 and further including applying, pellitizing, tableting, or granulating the nanocapsule matrix.

62.1 42. The method of claim 18 wherein the second aqueous composition comprises a cell recognition component.

43. A method of forming a nanocapsule, the method comprising:
dispersing a surfactant molecule into a first aqueous composition comprising a hydrophilic bioactive component, wherein the surfactant molecule has an HLB value of less than about 5.0 units, and wherein the surfactant molecule is adsorbed onto a surface of the hydrophilic component to form a surfactant micelle;
adding a biocompatible polymer to the first aqueous composition to form a stabilized aqueous composition comprising a plurality of stabilized surfactant micelles;
solidifying the stabilized surfactant micelles by dispersing the stabilized surfactant micelles into a second aqueous composition containing a solute for a time that is effective to form a first nanocapsule having a first diameter; and applying a cell recognition component to the nanocapsule, wherein the cell recognition component is effective to target an epithelial cell.

44. A method of administering a bioactive component to a cell, the method comprising:
administering an effective amount of a plurality of nanocapsules to an epithelial cell, an endothelial cell or any combination of either of these, wherein the nanocapsules comprise the bioactive component.

45. The method of claim 11 wherein the hydrophilic bioactive component is not entangled or embedded in the biocompatible polymer.

62.2 46. A method of directing a nanocapsule to a tumor cell, the method comprising:
forming a nanocapsule having a diameter of less than about 50 nm, wherein the nanocapsule comprises a bioactive component located within a core of a polymeric shell, and wherein the polymeric shell comprises a cell recognition component on a surface of the polymeric shell; and administering the nanocapsule to the tumor cell, wherein the tumor cell is capable of at least recognizing the cell recognition component of the nanocapsule, wherein the cell recognition component is effective to direct the nanocapsule to the tumor cell, and wherein the tumor cell forms a working relationship with the cell recognition component.

47. The method of claim 46 wherein the nanocapsule is transported into the tumor cell.

48. The method of claim 46 wherein the bioactive component is released within the tumor cell.

49. The method of claim 46 wherein forming the nanocapsule comprises:
dispersing surfactant molecules into a first hydrophilic composition, the first hydrophilic composition comprising a biaoctive component, wherein the surfactant molecules have an HLB
value of less than about 5.0 units, and wherein the surfactant molecules form a shell around the bioactive component to form a dispersion of surfactant micelles;
adding a biocompatible hydrophilic polymer to the dispersion of surfactant micelles to form the polymeric shell, wherein the polymeric shell surrounds the bioactive component, and 62.3 wherein the bioactive component is not entangled in the polymeric shell; and adding the cell recognition component to the surface of the polymeric shell.

50. A method of administering a bioactive component to a tumor cell, the method comprising:
administering an effective amount of a plurality of nanocapsules, wherein the nanocapsules comprise the bioactive component located within a core of a polymeric shell of the nanocapsule, wherein the bioactive component is not entangled with the polymeric shell, wherein the nanocapsule comprises at least one cell recognition component adsorbed onto a surface of the polymeric shell, wherein the tumor cell is at least capable of recognizing the cell recognition component, and wherein the tumor cell forms a working relationship with the cell recognition component.

51. The method of claim 50 wherein the cell recognition component is an antibody, a ligand, a peptide hormone, an ion, a polypeptide, a protein, a peptide, an oligopeptide, an oligonucleotide, or any combination of any of these.

52. The method of claim 50 wherein the cell recognition component is tenascin, a peptide derived from tenascin, an oligopeptide derived from tenascin, or any combination of any of these.

53. A method of delivering a macromolecule to a cell, the method comprising:
administering a nanocapsule to a surface of an epithelial cell, wherein the nanocapsule contains a macromolecule, wherein 62.4 the macromolecule is located within a core of the nanocapsule, wherein the macromolecule is not entangled with a polymeric shell of the nanocapsule, and wherein the nanocapsule has a diameter of less than about 50 nm.

54. The method of claim 53 wherein the macromolecule is a gene under control of a promoter.

55. The method of claim 53 wherein the macromolecule is an antisense oligonucleotide.

56. The method of claim 53 wherein the epithelial cell is a keratinized barrier epithelial cell.

57. A nanocapsule prepared by the method of claim 21.

58. A method of forming a nanocapsule, the method comprising:
dispersing a surfactant molecule into a first aqueous composition comprising a bioactive macromolecule, wherein the surfactant molecule has an HLB value of less than about 5.0 units, and wherein the surfactant molecule is adsorbed onto a surface of the bioactive molecule to form a surfactant micelle;
adding a biocompatible polymer and a cell recognition component to the first aqueous composition to form a stabilized aqueous composition comprising a plurality of stabilized surfactant micelles;
solidifying the stabilized surfactant micelles by dispersing the stabilized surfactant micelles into a second aqueous composition containing a solute for a time that is effective to 62.5 form a first nanocapsule having a first diameter; and wherein the cell recognition component is effective to direct the nanocapsule to a target cell.
CA2400172A 2000-02-28 2001-02-28 Nanocapsule encapsulation system and method Expired - Fee Related CA2400172C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US18528200P 2000-02-28 2000-02-28
US60/185,282 2000-02-28
PCT/US2001/006455 WO2001064164A2 (en) 2000-02-28 2001-02-28 Nanocapsule encapsulation system and method

Publications (2)

Publication Number Publication Date
CA2400172A1 true CA2400172A1 (en) 2001-09-07
CA2400172C CA2400172C (en) 2010-04-20

Family

ID=22680346

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2400172A Expired - Fee Related CA2400172C (en) 2000-02-28 2001-02-28 Nanocapsule encapsulation system and method

Country Status (9)

Country Link
US (2) US6632671B2 (en)
EP (1) EP1267946A4 (en)
JP (1) JP4751556B2 (en)
CN (1) CN1406140A (en)
AU (2) AU4724401A (en)
CA (1) CA2400172C (en)
HK (1) HK1048772A1 (en)
MX (1) MXPA02008361A (en)
WO (1) WO2001064164A2 (en)

Families Citing this family (154)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6433154B1 (en) * 1997-06-12 2002-08-13 Bristol-Myers Squibb Company Functional receptor/kinase chimera in yeast cells
US20030206958A1 (en) * 2000-12-22 2003-11-06 Cattaneo Maurizio V. Chitosan biopolymer for the topical delivery of active agents
AU4724401A (en) * 2000-02-28 2001-09-12 Genesegues Inc Nanocapsule encapsulation system and method
DE60135455D1 (en) 2000-05-16 2008-10-02 Univ Minnesota IT OF MULTI-NOZZLE ARRANGEMENT
US8067032B2 (en) 2000-12-22 2011-11-29 Baxter International Inc. Method for preparing submicron particles of antineoplastic agents
US20030096013A1 (en) * 2000-12-22 2003-05-22 Jane Werling Preparation of submicron sized particles with polymorph control
US20050048126A1 (en) 2000-12-22 2005-03-03 Barrett Rabinow Formulation to render an antimicrobial drug potent against organisms normally considered to be resistant to the drug
US9700866B2 (en) 2000-12-22 2017-07-11 Baxter International Inc. Surfactant systems for delivery of organic compounds
US7247338B2 (en) * 2001-05-16 2007-07-24 Regents Of The University Of Minnesota Coating medical devices
EP1401399A2 (en) * 2001-06-22 2004-03-31 Pfizer Products Inc. Pharmaceutical compositions containing polymer and drug assemblies
US7081489B2 (en) * 2001-08-09 2006-07-25 Florida State University Research Foundation Polymeric encapsulation of nanoparticles
CA2461349C (en) 2001-09-26 2011-11-29 Baxter International Inc. Preparation of submicron sized nanoparticles via dispersion and solvent or liquid phase removal
US20060003012A9 (en) 2001-09-26 2006-01-05 Sean Brynjelsen Preparation of submicron solid particle suspensions by sonication of multiphase systems
US7615676B2 (en) * 2001-11-30 2009-11-10 U.S. Department Of Veterans Affairs Transgenic screen and method for screening modulators of brain-derived neurotrophic factor (BDNF) production
US7491810B2 (en) * 2001-11-30 2009-02-17 U.S. Department Of Veterans Affairs Transgenic screen and method for screening modulators of brain-derived neurotrophic factor (BDNF) production
US20040038303A1 (en) * 2002-04-08 2004-02-26 Unger Gretchen M. Biologic modulations with nanoparticles
US7053034B2 (en) * 2002-04-10 2006-05-30 Salvona, Llc Targeted controlled delivery compositions activated by changes in pH or salt concentration
DE10236064A1 (en) * 2002-08-07 2004-02-19 Beiersdorf Ag Foaming sunscreen preparations
US6989196B2 (en) * 2002-10-02 2006-01-24 Florida State University Research Foundation Microencapsulation of magnetic material using heat stabilization
US7829694B2 (en) 2002-11-26 2010-11-09 Medtronic, Inc. Treatment of neurodegenerative disease through intracranial delivery of siRNA
US7605249B2 (en) * 2002-11-26 2009-10-20 Medtronic, Inc. Treatment of neurodegenerative disease through intracranial delivery of siRNA
US7618948B2 (en) 2002-11-26 2009-11-17 Medtronic, Inc. Devices, systems and methods for improving and/or cognitive function through brain delivery of siRNA
US7732591B2 (en) * 2003-11-25 2010-06-08 Medtronic, Inc. Compositions, devices and methods for treatment of huntington's disease through intracranial delivery of sirna
US7994149B2 (en) 2003-02-03 2011-08-09 Medtronic, Inc. Method for treatment of Huntington's disease through intracranial delivery of sirna
CA2540695A1 (en) * 2003-06-24 2004-12-29 Baxter International Inc. Specific delivery of drugs to the brain
US8986736B2 (en) * 2003-06-24 2015-03-24 Baxter International Inc. Method for delivering particulate drugs to tissues
WO2005011702A1 (en) * 2003-07-17 2005-02-10 Tibotec Pharmaceuticals Ltd. Process for preparing particles containing an antiviral
US9011880B2 (en) * 2003-10-21 2015-04-21 Igf Oncology, Llc Compounds and methods for treating cancer
EP1680073B1 (en) * 2003-10-21 2013-01-02 IGF Oncology, LLC Compounds and method for treating cancer
WO2005072292A2 (en) * 2004-01-24 2005-08-11 Hugh Mctavish Methods for enhancing radiation therapy
CA2554246A1 (en) * 2004-01-29 2005-08-11 Baxter International Inc. Nanosuspensions of anti-retroviral agents for increased central nervous system delivery
KR20050081092A (en) * 2004-02-12 2005-08-18 한국과학기술연구원 Composition and formulation of colloidal system comprising biocompatible aqueous-soluble polymer, and preparation method thereof
US7354980B1 (en) 2004-03-12 2008-04-08 Key Medical Technologies, Inc. High refractive index polymers for ophthalmic applications
US20050208090A1 (en) * 2004-03-18 2005-09-22 Medtronic, Inc. Methods and systems for treatment of neurological diseases of the central nervous system
CA2565236A1 (en) * 2004-05-06 2005-11-17 Ivrea Pharmaceuticals, Inc. Particles for the delivery of active agents
US7842281B2 (en) * 2004-05-10 2010-11-30 The Florida State University Research Foundation Magnetic particle composition for therapeutic hyperthermia
CN101310011A (en) * 2004-06-15 2008-11-19 巴克斯特国际公司 Ex-vivo application of solid microparticulate therapeutic agents
JP2008503590A (en) * 2004-06-21 2008-02-07 メドトロニック・インコーポレーテッド Medical systems and methods for delivering compositions to cells
EP1812082B1 (en) * 2004-10-21 2013-08-14 IGF Oncology, LLC Toxins and radionuclides coupled to IGF-1 receptor ligands for the treatment of cancer
US7446157B2 (en) * 2004-12-07 2008-11-04 Key Medical Technologies, Inc. Nanohybrid polymers for ophthalmic applications
WO2006065724A2 (en) * 2004-12-14 2006-06-22 Regents Of The University Of Minnesota Casein kinase 2 antisense therapy
US8871272B2 (en) 2005-02-14 2014-10-28 Australian Nuclear Science & Technology Organisation Layered nanoparticles
US20060222692A1 (en) * 2005-03-31 2006-10-05 Fairfield Clinical Trials Llc Method and compositions for transdermal administration of antimicrobial medications
EP1885854B1 (en) * 2005-05-06 2012-10-17 Medtronic, Inc. Methods and sequences to suppress primate huntington gene expression
US7902352B2 (en) * 2005-05-06 2011-03-08 Medtronic, Inc. Isolated nucleic acid duplex for reducing huntington gene expression
JP2008545808A (en) * 2005-05-23 2008-12-18 エラン・ファルマ・インターナショナル・リミテッド Nanoparticulate and controlled release compositions containing platelet aggregation inhibitors
US9133517B2 (en) * 2005-06-28 2015-09-15 Medtronics, Inc. Methods and sequences to preferentially suppress expression of mutated huntingtin
US20080280843A1 (en) * 2006-05-24 2008-11-13 Van Bilsen Paul Methods and kits for linking polymorphic sequences to expanded repeat mutations
ES2391729T3 (en) * 2005-10-14 2012-11-29 Vive Crop Protection Inc. Composite nanoparticles, nanoparticles and methods for their production
CN1962155A (en) * 2005-11-10 2007-05-16 鸿富锦精密工业（深圳）有限公司 CO2 laser welding apparatus
US7741396B2 (en) * 2005-11-23 2010-06-22 General Electric Company Composites having tunable dielectric constants, methods of manufacture thereof, and articles comprising the same
WO2007066247A2 (en) 2005-12-08 2007-06-14 Koninklijke Philips Electronics, N.V. System and method for monitoring in vivo drug release using overhauser-enhanced nmr
US9108217B2 (en) 2006-01-31 2015-08-18 Nanocopoeia, Inc. Nanoparticle coating of surfaces
CA2637883C (en) 2006-01-31 2015-07-07 Regents Of The University Of Minnesota Electrospray coating of objects
EP2529761B1 (en) 2006-01-31 2017-06-14 Nanocopoeia, Inc. Nanoparticle coating of surfaces
US20100119827A1 (en) * 2006-04-25 2010-05-13 Research Foundation Of The City University Of New York Polymer submicron particle preparation by surfactant-mediated precipitation
US9273356B2 (en) 2006-05-24 2016-03-01 Medtronic, Inc. Methods and kits for linking polymorphic sequences to expanded repeat mutations
WO2007149868A2 (en) * 2006-06-20 2007-12-27 The Regents Of The University Of California Controlled release encapsulated anti-bacterial and anti-inflammatory nanoparticles
US20080039415A1 (en) * 2006-08-11 2008-02-14 Gregory Robert Stewart Retrograde transport of sirna and therapeutic uses to treat neurologic disorders
EP2051696A2 (en) * 2006-08-18 2009-04-29 Morton Grove Pharmaceuticals, Inc. Stable liquid levetiracetam compositions and methods
US8324367B2 (en) 2006-11-03 2012-12-04 Medtronic, Inc. Compositions and methods for making therapies delivered by viral vectors reversible for safety and allele-specificity
US9375440B2 (en) * 2006-11-03 2016-06-28 Medtronic, Inc. Compositions and methods for making therapies delivered by viral vectors reversible for safety and allele-specificity
US7988668B2 (en) * 2006-11-21 2011-08-02 Medtronic, Inc. Microsyringe for pre-packaged delivery of pharmaceuticals
US7819842B2 (en) * 2006-11-21 2010-10-26 Medtronic, Inc. Chronically implantable guide tube for repeated intermittent delivery of materials or fluids to targeted tissue sites
US9040816B2 (en) 2006-12-08 2015-05-26 Nanocopoeia, Inc. Methods and apparatus for forming photovoltaic cells using electrospray
US20080171906A1 (en) * 2007-01-16 2008-07-17 Everaerts Frank J L Tissue performance via hydrolysis and cross-linking
EP1955695A1 (en) * 2007-02-06 2008-08-13 Institut National De La Sante Et De La Recherche Medicale (Inserm) Nanocapsules of lipophilic complexes of nucleic acids
US20080193766A1 (en) * 2007-02-13 2008-08-14 Northern Nanotechnologies Control of Transport to and from Nanoparticle Surfaces
US8425900B2 (en) * 2007-04-30 2013-04-23 Agency For Science, Technology And Research Method of delivering a protein into a cell
WO2008135828A2 (en) 2007-05-03 2008-11-13 Pfizer Products Inc. Nanoparticles comprising a drug, ethylcellulose, and a bile salt
WO2008135855A2 (en) 2007-05-03 2008-11-13 Pfizer Products Inc. Nanoparticles comprising a cholesteryl ester transfer protein inhibitor and a nonionizable polymer
US9545384B2 (en) 2007-06-04 2017-01-17 Bend Research, Inc. Nanoparticles comprising drug, a non-ionizable cellulosic polymer and tocopheryl polyethylene glocol succinate
US8974827B2 (en) 2007-06-04 2015-03-10 Bend Research, Inc. Nanoparticles comprising a non-ionizable cellulosic polymer and an amphiphilic non-ionizable block copolymer
US20100173001A1 (en) * 2007-06-14 2010-07-08 Genesegues, Inc. Metal Ion-Treated Biocompatible Polymers Useful for Nanoparticles
US20090042825A1 (en) * 2007-08-06 2009-02-12 Majed Matar Composition, method of preparation & application of concentrated formulations of condensed nucleic acids with a cationic lipopolymer
US9144546B2 (en) 2007-08-06 2015-09-29 Clsn Laboratories, Inc. Nucleic acid-lipopolymer compositions
US7973019B1 (en) 2007-10-03 2011-07-05 Alcon Research, Ltd. Transferrin/transferrin receptor-mediated siRNA delivery
TW200930405A (en) 2007-11-15 2009-07-16 Alcon Res Ltd Low density lipoprotein receptor-mediated siRNA delivery
US8124594B2 (en) * 2007-11-30 2012-02-28 Chemi Nutra, Llc Methods using phosphatidylserine, lysophosphatidylserine, and/or salts thereof to increase testosterone levels
US9233078B2 (en) 2007-12-06 2016-01-12 Bend Research, Inc. Nanoparticles comprising a non-ionizable polymer and an Amine-functionalized methacrylate copolymer
WO2009073215A1 (en) 2007-12-06 2009-06-11 Bend Research, Inc. Pharmaceutical compositions comprising nanoparticles and a resuspending material
WO2009085083A1 (en) * 2007-12-28 2009-07-09 Dow Global Technologies Inc. Phase compensation film comprising polymer nanoparticles imbibed with liquid crystal material
US20100294989A1 (en) * 2007-12-28 2010-11-25 Shaffer Ii Edward O Small scale functional materials
WO2009101613A1 (en) * 2008-02-11 2009-08-20 Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd. Beta-casein assemblies for mucosal delivery of therapeutic bioactive agents
EP2252269A1 (en) * 2008-02-11 2010-11-24 Technion Research and Development Foundation, Ltd. Casein particles encapsulating therapeutically active agents and uses thereof
US8871276B2 (en) 2008-02-11 2014-10-28 Technion Research And Development Foundation Ltd. Beta-casein assemblies for mucosal delivery of therapeutic bioactive agents
US8865222B2 (en) * 2008-02-11 2014-10-21 Technion Research And Development Foundation Ltd. Beta-casein assemblies for enrichment of food and beverages and methods of preparation thereof
WO2009105792A1 (en) * 2008-02-18 2009-08-27 Csir Nanoparticle carriers for drug administration and process for producing same
US9364443B2 (en) 2008-03-05 2016-06-14 Baxter International, Inc. Compositions and methods for drug delivery
IE20080211A1 (en) 2008-03-20 2009-11-25 Nat Univ Ireland Biodegradable nanoshells for delivery of therapeutic and/or imaging molecules
US20090269405A1 (en) * 2008-04-08 2009-10-29 Appian Labs, Llc Enzyme mediated delivery system
US20100010102A1 (en) * 2008-07-09 2010-01-14 Board Of Regents, The University Of Texas System Triggered release of drugs from polymer particles
WO2010102065A1 (en) 2009-03-05 2010-09-10 Bend Research, Inc. Pharmaceutical compositions of dextran polymer derivatives
US10952965B2 (en) * 2009-05-15 2021-03-23 Baxter International Inc. Compositions and methods for drug delivery
AU2010254550B2 (en) 2009-05-27 2015-10-15 Selecta Biosciences, Inc. Targeted synthetic nanocarriers with pH sensitive release of immunomodulatory agents
WO2011017382A2 (en) * 2009-08-03 2011-02-10 The Regents Of The University Of California Nanofibers and morphology shifting micelles
US8470304B2 (en) 2009-08-04 2013-06-25 Avidas Pharmaceuticals Llc Therapeutic vitamin D sun-protecting formulations and methods for their use
EP2470554B1 (en) 2009-08-26 2017-06-28 Selecta Biosciences, Inc. Compositions that induce t cell help
US9650244B2 (en) 2010-08-25 2017-05-16 Genesegues, Inc. Topical vaccination via DNA microparticles
US20120076735A1 (en) * 2010-03-24 2012-03-29 Genesegues, Inc. Nanoparticles for Extravascular Administration
AU2011258156B2 (en) 2010-05-26 2016-11-24 Selecta Biosciences, Inc. Multivalent synthetic nanocarrier vaccines
US8815294B2 (en) 2010-09-03 2014-08-26 Bend Research, Inc. Pharmaceutical compositions of dextran polymer derivatives and a carrier material
US8709487B1 (en) 2011-04-25 2014-04-29 The United States Of America As Represented By The Secretary Of The Army Nanoparticle entrapment of materials
WO2012149393A2 (en) 2011-04-29 2012-11-01 Selecta Biosciences, Inc. Tolerogenic synthetic nanocarriers for antigen-specific deletion of t effector cells
US9084727B2 (en) 2011-05-10 2015-07-21 Bend Research, Inc. Methods and compositions for maintaining active agents in intra-articular spaces
WO2012161677A1 (en) 2011-05-20 2012-11-29 Alcon Research, Ltd. TRANSFERRIN/TRANSFERRIN RECEPTOR-MEDIATED siRNA DELIVERY
AU2012290306B2 (en) 2011-07-29 2017-08-17 Selecta Biosciences, Inc. Synthetic nanocarriers that generate humoral and cytotoxic T lymphocyte (CTL) immune responses
KR20140051357A (en) * 2011-08-26 2014-04-30 애로우헤드 리서치 코오포레이션 Poly(vinyl ester) polymers for in vivo nucleic acid delivery
US9474715B2 (en) * 2011-11-30 2016-10-25 Andreas Voigt Polymeric drug-delivery material, method for manufacturing thereof and method for delivery of a drug-delivery composition
EP2968510B1 (en) 2013-03-14 2019-10-09 President and Fellows of Harvard College Nanoparticle-based compositions
EA201592103A3 (en) 2013-05-03 2016-08-31 Селекта Байосайенсиз, Инк. METHODS AND COMPOSITIONS FOR STRENGTHENING CD4 + REGULATORY T-CELLS
AU2014274894A1 (en) 2013-06-04 2015-11-26 Selecta Biosciences, Inc. Repeated administration of non-immunosupressive antigen specific immunotherapeutics
CN103550155A (en) * 2013-11-08 2014-02-05 江南大学 Method of restraining production of lysophosphatide in lecithin/non-ionic surfactant mixed micelles
US9675671B2 (en) 2014-01-12 2017-06-13 Igf Oncology, Llc Fusion proteins containing insulin-like growth factor-1 and epidermal growth factor and variants thereof and uses thereof
US20150374815A1 (en) 2014-06-25 2015-12-31 Selecta Biosciences, Inc. Methods and compositions for treatment with synthetic nanocarriers and immune checkpoint inhibitors
SG10201902499VA (en) 2014-09-03 2019-04-29 Genesegues Inc Therapeutic nanoparticles and related compositions, methods and systems
WO2016037163A1 (en) 2014-09-07 2016-03-10 Selecta Biosciences, Inc. Methods and compositions for attenuating gene therapy anti-viral transfer vector immune responses
MX2017005904A (en) 2014-11-05 2017-06-27 Selecta Biosciences Inc Methods and compositions related to synthetic nanocarriers with rapamycin in a stable, super-saturated state.
KR101663775B1 (en) * 2014-11-13 2016-10-07 주식회사 엘지생활건강 Composition for stabilizing polyphenolic effective ingredient
EP3340982B1 (en) 2015-08-26 2021-12-15 Achillion Pharmaceuticals, Inc. Compounds for treatment of immune and inflammatory disorders
AR106018A1 (en) 2015-08-26 2017-12-06 Achillion Pharmaceuticals Inc ARYL, HETEROARYL AND HETEROCYCLIC COMPOUNDS FOR THE TREATMENT OF MEDICAL DISORDERS
MX2018011012A (en) 2016-03-11 2019-03-28 Selecta Biosciences Inc Formulations and doses of pegylated uricase.
AU2017290593A1 (en) 2016-06-27 2019-01-03 Achillion Pharmaceuticals, Inc. Quinazoline and indole compounds to treat medical disorders
US20180085319A1 (en) 2016-09-27 2018-03-29 Takashi Kei Kishimoto Methods and compositions for treating cancer
CN110177553A (en) 2016-11-17 2019-08-27 北卡罗来纳大学教堂山分校 Alkyl Pyrrolopyrimidine is like object and its preparation and application
AU2018205496A1 (en) 2017-01-07 2019-07-25 Selecta Biosciences, Inc. Patterned dosing of immunosuppressants coupled to synthetic nanocarriers
WO2018169811A1 (en) 2017-03-11 2018-09-20 Selecta Biosciences, Inc. Methods and compositions related to combined treatment with anti-inflammatories and synthetic nanocarriers comprising an immunosuppressant
CA3059593A1 (en) 2017-05-21 2018-11-29 Igf Oncology, Llc An insulin-like growth factor-chemotherapeputic conjugate for treating myelodysplastic syndrome
WO2019075360A1 (en) 2017-10-13 2019-04-18 Selecta Biosciences, Inc. Methods and compositions for attenuating anti-viral transfer vector igm responses
US20190151470A1 (en) * 2018-01-21 2019-05-23 RoverMed BioSciences, LLC Nanoparticles comprising protein-polynucleotide complexes and for delivering protein based complexes
CN108414393A (en) * 2018-06-13 2018-08-17 安徽中医药大学 A method of measuring entrapment efficiency of liposome
EP3823980A1 (en) 2018-07-16 2021-05-26 Selecta Biosciences, Inc. Methods and compositions of otc constructs and vectors
WO2020018587A1 (en) 2018-07-16 2020-01-23 Selecta Biosciences, Inc. Methods and compositions of mma constructs and vectors
JP2021535112A (en) 2018-08-20 2021-12-16 アキリオン ファーマシューティカルズ，インコーポレーテッド Pharmaceutical compounds for the treatment of medical disorders of complement D factor
EP3866773A4 (en) 2018-10-16 2022-10-26 Georgia State University Research Foundation, Inc. Carbon monoxide prodrugs for the treatment of medical disorders
CN114126666A (en) 2019-04-28 2022-03-01 西莱克塔生物科技公司 Methods for treating subjects with pre-existing immunity to viral transfer vectors
BR112021023594A2 (en) 2019-05-28 2022-02-08 Selecta Biosciences Inc Methods and compositions for attenuated antiviral transfer vector immune response
JP2022535121A (en) 2019-06-04 2022-08-04 セレクタ バイオサイエンシーズ インコーポレーテッド Formulation and dosage of pegylated uricase
EP4048269A1 (en) 2019-10-21 2022-08-31 Selecta Biosciences, Inc. Methods and compositions for treating liver diseases and disorders
EP4054531A1 (en) 2019-11-08 2022-09-14 Selecta Biosciences, Inc. Formulations and doses of pegylated uricase
KR20220146559A (en) 2020-02-26 2022-11-01 셀렉타 바이오사이언시즈, 인크. Methods and Compositions Using Synthetic Nanocarriers Containing Immunosuppressants
MX2022011248A (en) 2020-03-11 2022-12-15 Selecta Biosciences Inc Methods and compositions related to synthetic nanocarriers.
KR20230002613A (en) 2020-04-14 2023-01-05 셀렉타 바이오사이언시즈, 인크. Methods and compositions for inducing autophagy
CA3207247A1 (en) 2021-01-05 2022-07-14 Selecta Biosciences, Inc. Viral vector dosing protocols
EP4319747A1 (en) 2021-04-09 2024-02-14 Selecta Biosciences, Inc. Synthetic nanocarriers comprising an immunosuppressant in combination with high affinity il-2 receptor agonists to enhance immune tolerance
WO2022261148A1 (en) * 2021-06-09 2022-12-15 Scribe Therapeutics Inc. Compositions of glycoprotein particles
WO2023064367A1 (en) 2021-10-12 2023-04-20 Selecta Biosciences, Inc. Methods and compositions for attenuating anti-viral transfer vector igm responses
CA3235269A1 (en) 2021-10-12 2023-04-20 Cartesian Therapeutics, Inc. Viral vector dosing protocols
WO2023086615A1 (en) 2021-11-14 2023-05-19 Selecta Biosciences, Inc. Multiple dosing with viral vectors
US20230263906A1 (en) 2022-01-10 2023-08-24 Selecta Biosciences, Inc. High affinity il-2 receptor agonists and synthetic nanocarrier dose sparing
WO2023172624A1 (en) 2022-03-09 2023-09-14 Selecta Biosciences, Inc. Immunosuppressants in combination with anti-igm agents and related dosing
WO2023172628A1 (en) 2022-03-09 2023-09-14 Selecta Biosciences, Inc. Immunosuppressant in combination with high affinity il-2 receptor agonists and related dosing
WO2023183568A1 (en) 2022-03-25 2023-09-28 Selecta Biosciences, Inc. Synthetic nanocarriers comprising an immunosuppressant in combination with high affinity il-2 receptor agonists and anti-igm agents
US20230381277A1 (en) 2022-04-08 2023-11-30 Selecta Biosciences, Inc. High affinity il-2 receptor agonists and immunosuppressants to enhance immune tolerance

Family Cites Families (68)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4107288A (en) 1974-09-18 1978-08-15 Pharmaceutical Society Of Victoria Injectable compositions, nanoparticles useful therein, and process of manufacturing same
DK143689C (en) * 1975-03-20 1982-03-15 J Kreuter PROCEDURE FOR THE PREPARATION OF AN ADVERTISED VACCINE
US4177177A (en) 1976-03-26 1979-12-04 El Aasser Mohamed S Polymer emulsification process
FR2504408B1 (en) 1981-04-24 1986-02-14 Couvreur Patrick PROCESS FOR THE PREPARATION OF SUBMICROSCOPIC PARTICLES, PARTICLES THUS OBTAINED AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM
ES2053549T3 (en) 1986-08-11 1994-08-01 Innovata Biomed Ltd A PROCESS FOR THE PREPARATION OF AN APPROPRIATE PHARMACEUTICAL FORMULATION FOR INHALATION.
US4920016A (en) 1986-12-24 1990-04-24 Linear Technology, Inc. Liposomes with enhanced circulation time
FR2634397B2 (en) 1986-12-31 1991-04-19 Centre Nat Rech Scient PROCESS FOR THE PREPARATION OF DISPERSIBLE COLLOIDAL SYSTEMS OF A PROTEIN IN THE FORM OF NANOPARTICLES
JP2564386B2 (en) 1987-04-16 1996-12-18 クリスチャン ビンチャエドラー Method for preparing powder of water-insoluble polymer
US4937119A (en) 1988-12-15 1990-06-26 Hoechst Celanese Corp. Textured organic optical data storage media and methods of preparation
PH30995A (en) 1989-07-07 1997-12-23 Novartis Inc Sustained release formulations of water soluble peptides.
IL98744A0 (en) * 1990-07-06 1992-07-15 Gen Hospital Corp Method of studying biological tissue using monocrystalline particles
US5487390A (en) * 1990-10-05 1996-01-30 Massachusetts Institute Of Technology Gas-filled polymeric microbubbles for ultrasound imaging
US5145684A (en) * 1991-01-25 1992-09-08 Sterling Drug Inc. Surface modified drug nanoparticles
GB9116610D0 (en) 1991-08-01 1991-09-18 Danbiosyst Uk Preparation of microparticles
US6113946A (en) 1992-04-03 2000-09-05 The Regents Of The University Of California Self-assembling polynucleotide delivery system comprising dendrimer polycations
US6197346B1 (en) 1992-04-24 2001-03-06 Brown Universtiy Research Foundation Bioadhesive microspheres and their use as drug delivery and imaging systems
DE4223169C1 (en) 1992-07-10 1993-11-25 Ferring Arzneimittel Gmbh Process for the microencapsulation of water-soluble active substances
GB9300875D0 (en) * 1993-01-18 1993-03-10 Ucb Sa Nanocapsule containing pharmaceutical compositions
US5558855A (en) * 1993-01-25 1996-09-24 Sonus Pharmaceuticals Phase shift colloids as ultrasound contrast agents
DK0693924T4 (en) 1993-02-22 2008-08-04 Abraxis Bioscience Inc Process for (in vivo) delivery of biological materials and compositions suitable therefor
US5439686A (en) 1993-02-22 1995-08-08 Vivorx Pharmaceuticals, Inc. Methods for in vivo delivery of substantially water insoluble pharmacologically active agents and compositions useful therefor
ATE258685T1 (en) 1993-03-09 2004-02-15 Baxter Int MACROMOLECULAR MICROPARTICLES AND METHOD FOR THE PRODUCTION THEREOF
FR2704754B1 (en) 1993-05-07 1995-06-30 Oreal USE OF AN ALKYL ESTER OF GLUTATHION IN A COSMETIC OR DERMATOLOGICAL COMPOSITION FOR TOPICAL TREATMENT OF CUTANEOUS AGING.
WO1995003789A1 (en) 1993-07-28 1995-02-09 The Johns Hopkins University School Of Medicine Controlled release of pharmaceutically active substances from coacervate microcapsules
CA2136373A1 (en) * 1993-11-29 1995-05-30 Steven W. Medina Ethoxylated acetylenic glycols having low dynamic surface tension
DE4341114A1 (en) * 1993-12-02 1995-06-08 Ifac Gmbh Emulsions comprising non-aqueous phase dispersed in oil phase
US5962427A (en) 1994-02-18 1999-10-05 The Regent Of The University Of Michigan In vivo gene transfer methods for wound healing
FR2721510B1 (en) 1994-06-22 1996-07-26 Rhone Poulenc Rorer Sa Nanoparticles filterable under sterile conditions.
US5858398A (en) * 1994-11-03 1999-01-12 Isomed Inc. Microparticular pharmaceutical compositions
US5629021A (en) 1995-01-31 1997-05-13 Novavax, Inc. Micellar nanoparticles
US6165988A (en) 1995-02-10 2000-12-26 Christian Noe Medicament in particulate form
US5736156A (en) * 1995-03-22 1998-04-07 The Ohio State University Liposomal anf micellular stabilization of camptothecin drugs
US6051258A (en) 1995-06-07 2000-04-18 Emisphere Technologies, Inc. Proteinoid emulsions and methods for preparation and use thereof
US6033645A (en) 1996-06-19 2000-03-07 Unger; Evan C. Methods for diagnostic imaging by regulating the administration rate of a contrast agent
US6139819A (en) * 1995-06-07 2000-10-31 Imarx Pharmaceutical Corp. Targeted contrast agents for diagnostic and therapeutic use
ES2177592T3 (en) 1995-07-05 2002-12-16 Europ Economic Community BIOCOMPATIBLE AND BIODEGRADABLE NANOPARTICLES FOR THE ABSORPTION AND ADMINISTRATION OF PROTEINIC MEDICINES.
JPH11510142A (en) 1995-07-21 1999-09-07 ブラウン・ユニバーシティ・リサーチ・ファンデーション Gene therapy using nucleic acid-loaded polymer microparticles
US6143211A (en) 1995-07-21 2000-11-07 Brown University Foundation Process for preparing microparticles through phase inversion phenomena
DE69636074T2 (en) * 1995-09-08 2007-05-03 Beth Israel Deaconess Medical Center, Boston INSULATION OF MICRODOMANS OF KAVEOLAE AND GPI ANCHORED PROTEINS
KR0180334B1 (en) * 1995-09-21 1999-03-20 김윤 Drug messenger using el-2l-2 micelle and method for sealing drug to it
US5648097A (en) 1995-10-04 1997-07-15 Biotek, Inc. Calcium mineral-based microparticles and method for the production thereof
FR2742357B1 (en) 1995-12-19 1998-01-09 Rhone Poulenc Rorer Sa STABILIZED AND FILTRABLE NANOPARTICLES UNDER STERILE CONDITIONS
DE19605279A1 (en) 1996-02-13 1997-08-14 Hoechst Ag Target cell-specific vectors for the introduction of genes into cells, drugs containing such vectors and their use
KR100236771B1 (en) 1997-04-01 2000-02-01 성재갑 Hyaluronate microparticles for sustained release of drug
US5874064A (en) 1996-05-24 1999-02-23 Massachusetts Institute Of Technology Aerodynamically light particles for pulmonary drug delivery
US6143037A (en) 1996-06-12 2000-11-07 The Regents Of The University Of Michigan Compositions and methods for coating medical devices
WO1997049387A1 (en) * 1996-06-27 1997-12-31 G.D. Searle And Co. Particles comprising amphiphilic copolymers, having a cross-linked shell domain and an interior core domain, useful for pharmaceutical and other applications
FR2751222B1 (en) * 1996-07-16 1998-10-09 Capsulis COMPOSITIONS CONTAINING AT LEAST ONE NUCLEIC ACID AND THEIR APPLICATIONS IN THE BIOMEDICAL FIELD, PARTICULARLY IN GENE THERAPY
US6030956A (en) * 1996-10-24 2000-02-29 Boulikas; Teni Combination gene therapy for human cancers
WO1998028423A2 (en) 1996-12-20 1998-07-02 Board Of Regents, The University Of Texas System Compositions and methods of use for osteoclast inhibitory factors
US5874111A (en) 1997-01-07 1999-02-23 Maitra; Amarnath Process for the preparation of highly monodispersed polymeric hydrophilic nanoparticles
EP0860167A1 (en) 1997-01-30 1998-08-26 Robert Gurny RNA-and DNA- based active agents in nanoparticles
WO1998040510A1 (en) * 1997-03-11 1998-09-17 Regents Of The University Of Minnesota Dna-based transposon system for the introduction of nucleic acid into dna of a cell
JP4718653B2 (en) * 1997-03-12 2011-07-06 アボツト・ラボラトリーズ Hydrophilic two-component system for administration of cyclosporine
AU6229498A (en) * 1997-04-07 1998-10-30 Daiichi Pharmaceutical Co., Ltd. Composition for gene introduction into cell
DE19723308A1 (en) * 1997-06-04 1998-12-10 Wolfgang A Prof Dr Wohlrab Microemulsions useful for topical administration of e.g. local anaesthetics
IL133672A0 (en) 1997-06-27 2001-04-30 Vivorx Pharmaceuticals Inc Novel formulations of pharmacological agents, methods for the preparation thereof and methods for the use thereof
US6165440A (en) 1997-07-09 2000-12-26 Board Of Regents, The University Of Texas System Radiation and nanoparticles for enhancement of drug delivery in solid tumors
MY131805A (en) * 1997-09-18 2007-09-28 Biogen Idec Inc Synergistic composition and methods for treating neoplastic or cancerous growths and for restoring or boosting hematopoiesis.
WO1999033558A1 (en) 1997-12-29 1999-07-08 Universite De Geneve Method for producing an aqueous colloidal dispersion of nanoparticles
IT1298575B1 (en) * 1998-02-06 2000-01-12 Vectorpharma Int PHARMACEUTICAL COMPOSITIONS IN THE FORM OF NANOPARTICLES INCLUDING LIPID SUBSTANCES AND ANTIPHILIC SUBSTANCES AND RELATED PROCESS OF
CA2335472C (en) 1998-06-19 2008-10-28 Rtp Pharma Inc. Processes to generate submicron particles of water-insoluble compounds
AU767737B2 (en) * 1998-11-20 2003-11-20 Skyepharma Canada Inc. Method of preparing stable suspensions of insoluble microparticles
EP1154734B1 (en) 1999-02-12 2014-10-01 ProChon Biotech Ltd. Injectable collagen-based system for delivery of cells
AU4724401A (en) * 2000-02-28 2001-09-12 Genesegues Inc Nanocapsule encapsulation system and method
US20040038303A1 (en) * 2002-04-08 2004-02-26 Unger Gretchen M. Biologic modulations with nanoparticles
WO2006065724A2 (en) * 2004-12-14 2006-06-22 Regents Of The University Of Minnesota Casein kinase 2 antisense therapy
WO2007130873A2 (en) * 2006-04-28 2007-11-15 Regents Of The University Of Minnesota Liver-specific nanocapsules and methods of using

Also Published As

Publication number Publication date
HK1048772A1 (en) 2003-04-17
EP1267946A2 (en) 2003-01-02
US20030170893A1 (en) 2003-09-11
AU4724401A (en) 2001-09-12
EP1267946A4 (en) 2008-07-02
WO2001064164A2 (en) 2001-09-07
JP4751556B2 (en) 2011-08-17
CA2400172C (en) 2010-04-20
JP2003524654A (en) 2003-08-19
US6632671B2 (en) 2003-10-14
WO2001064164A3 (en) 2001-12-20
CN1406140A (en) 2003-03-26
AU2001247244B2 (en) 2005-06-02
MXPA02008361A (en) 2004-05-17
US20040137071A1 (en) 2004-07-15

Similar Documents

Publication Publication Date Title
CA2400172A1 (en) Nanocapsule encapsulation system and method
JP3778575B2 (en) Drug targeting system, preparation method thereof and use thereof
US6284283B1 (en) Method of producing sub-micron particles of biologically active agents and uses thereof
EP0740548B1 (en) Drug targeting system, method for preparing same and its use
Müller et al. Surface modification of iv injectable biodegradable nanoparticles with poloxamer polymers and poloxamine 908
US6296842B1 (en) Process for the preparation of polymer-based sustained release compositions
US6071497A (en) Microparticles for lung delivery comprising diketopiperazine
JP2003524654A5 (en)
US5989463A (en) Methods for fabricating polymer-based controlled release devices
JPH10503198A (en) Controlled release of metal cation stabilized interferon
AU772910B2 (en) Method of producing submicron particles of a labile agent
EP1765294B1 (en) Nucleic acid microspheres, production and delivery thereof
Abd El-Hameed et al. Preparation and in vitro characterisation of mucoadhesive polymeric microspheres as intra-nasal delivery systems
JP3884484B2 (en) Preparation of particles for inhalation
US20050163714A1 (en) Capsules of multilayered neutral polymer films associated by hydrogen bonding
WO1989003207A1 (en) A drug composition with microspheres and process for its preparation
JPH11506764A (en) Non-aggregated erythropoietin sustained release composition
JP2000109426A (en) Preparation of pharmaceutically active particle
JP2004534721A5 (en)
WO2004064752A2 (en) Method of preparing sustained release microparticles
GB2170104A (en) Coated pharmaceutical dosage forms
Gref et al. Poly (ethyleneglycol)-coated nanospheres: potential carriers for intravenous drug administration
US7268214B2 (en) Membrane translocating peptide drug delivery system
WO1998007412A1 (en) Controlled release microparticles with a hydrophobic material
El-Gibaly et al. Effect of hexacosanol on the characteristics of novel sustained-release allopurinol solid lipospheres (SLS): factorial design application and product evaluation

Legal Events

Date Code Title Description
EEER Examination request
MKLA Lapsed
MKLA Lapsed

Effective date: 20120228