CA2393982A1 - Use of wicking agent to eliminate wash steps for optical diffraction-based biosensors - Google Patents

Use of wicking agent to eliminate wash steps for optical diffraction-based biosensors Download PDF

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Publication number
CA2393982A1
CA2393982A1 CA002393982A CA2393982A CA2393982A1 CA 2393982 A1 CA2393982 A1 CA 2393982A1 CA 002393982 A CA002393982 A CA 002393982A CA 2393982 A CA2393982 A CA 2393982A CA 2393982 A1 CA2393982 A1 CA 2393982A1
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CA
Canada
Prior art keywords
analyte
polymer film
diffraction
wicking agent
specific
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Granted
Application number
CA002393982A
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French (fr)
Other versions
CA2393982C (en
Inventor
Rosann M. Kaylor
Abraham B. Choi
Michael Heinrich Herbert Grunze
Chibueze Obinna Chidebelu-Eze
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Kimberly Clark Worldwide Inc
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Individual
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Publication of CA2393982A1 publication Critical patent/CA2393982A1/en
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Publication of CA2393982C publication Critical patent/CA2393982C/en
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Expired - Fee Related legal-status Critical Current

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Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N23/00—Investigating or analysing materials by the use of wave or particle radiation, e.g. X-rays or neutrons, not covered by groups G01N3/00 – G01N17/00, G01N21/00 or G01N22/00
    • G01N23/20—Investigating or analysing materials by the use of wave or particle radiation, e.g. X-rays or neutrons, not covered by groups G01N3/00 – G01N17/00, G01N21/00 or G01N22/00 by using diffraction of the radiation by the materials, e.g. for investigating crystal structure; by using scattering of the radiation by the materials, e.g. for investigating non-crystalline materials; by using reflection of the radiation by the materials
    • G01N23/207—Diffractometry using detectors, e.g. using a probe in a central position and one or more displaceable detectors in circumferential positions
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54366—Apparatus specially adapted for solid-phase testing
    • G01N33/54373—Apparatus specially adapted for solid-phase testing involving physiochemical end-point determination, e.g. wave-guides, FETS, gratings
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/569—Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277—Apparatus
    • B01J2219/00351—Means for dispensing and evacuation of reagents
    • B01J2219/00382—Stamping
    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B60/00—Apparatus specially adapted for use in combinatorial chemistry or with libraries
    • C40B60/14—Apparatus specially adapted for use in combinatorial chemistry or with libraries for creating libraries
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/808—Optical sensing apparatus
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S436/00—Chemistry: analytical and immunological testing
    • Y10S436/805—Optical property

Abstract

The present invention provides an inexpensive and sensitive system and metho d for detecting analytes present in a medium. The system comprises a diffracti on enhancing element, such as functionalized micropsheres, which are modified such that they are capable of binding with a target analyte. Additionally, t he system comprises a polymer film, which may include a metal coating, upon whi ch is printed a specific, predetermined pattern of analyte-specific receptors. Finally, the system includes a wicking agent which permits the system to be a single step system which avoids the necessity of any additional rinsing step s. Upon attachment of a target analyte to select areas of the polymer film, either directly or with the diffraction enhancing element, diffraction of transmitted and/or reflected light occurs via the physical dimensions and defined, precise placement of the analyte. A diffraction image, such as a hologram, is produced which can be easily seen with the eye or optionally, with a sensing device.

Claims (47)

1. A method of detecting an analyte in a medium comprising:
contacting the medium with a sensing device, the sensing device comprising:
a) a polymer film;
b) an analyte-specific receptor layer printed in a pattern onto the polymer film wherein the analyte-specific receptor layer has a receptor material thereon that is specific for the analyte; and c) a wicking agent on the layer of the analyte-specific receptor layer;
transmitting a light through the wicking agent and the polymer film; and detecting presence of the analyte by detecting a pattern formed by diffraction of the transmitted light.
2. The method of Claim 1, wherein the analyte-specific receptor layer is printed in a pattern such that when the sensing device binds an analyte, the sensing device diffracts transmitted light to form a diffraction pattern.
3. The method of Claim 2, wherein the diffraction pattern is visible to an unaided eye.
4. The method of Claim 1, further comprising a metal coating on the polymer film and wherein the analyte-specific receptor layer is printed onto the metal coating.
5. The method of Claim 4, wherein the metal is selected from gold, silver, chromium, nickel, platinum, aluminum, iron, copper, gold oxide, chromium oxide or zirconium.
6. The method of Claim 5, wherein the metal is gold.
7. The method of Claim 6, wherein the gold coating is between approximately 1 nanometer and 1000 nanometers in thickness.
8. The method of Claim 1, wherein the polymer film is selected from polyethylene-terephthalate, acrylonitrile-butadiene-styrene, acrylonitrile-methyl acrylate copolymer, cellophane, cellulosic polymers such as ethyl cellulose, cellulose acetate, cellulose acetate butyrate, cellulose propionate, cellulose triacetate, polyethylene, polyethylene - vinyl acetate copolymers, ionomers (ethylene polymers) polyethylene-nylon copolymers, nylon, polypropylene, methyl pentene polymers, polyvinyl fluoride, or aromatic polysulfones.
9. The method of Claim 8, wherein the polymer film is polyethylene-terephthalate.
10. The method of Claim 1, wherein the wicking agent is selected from a nitrocellulose membrane, a cellulose acetate membrane, or a glass microfiber structure.
11. The method of Claim 1, wherein the polymer film has an optical transparency between 5% and 95%.
12. The method of Claim 1, wherein the polymer film has an optical transparency between approximately 20% and 80%.
13. The method of Claim 1, wherein the pattern formed is a holographic pattern.
14. The method of Claim 1, wherein the analyte is selected from bacteria, yeast, fungus, virus, rheumatoid factor, IgG, IgM, IgA and IgE antibodies, carcinoembryonic antigen, streptococcus Group A antigen, viral antigens, antigens associated with autoimmune disease, allergens, tumor antigens, streptococcus Group B antigen, HIV I or HIV II antigen, antibodies viruses, antigens specific to RSV" an antibody, antigen, enzyme, hormone, polysaccharide, protein, lipid, carbohydrate, drug or nucleic acid, Neisseria meningitides groups A, B, C, Y and W sub 135, Streptococcus pneumoniae, E. coli K1 , Haemophilus influenza type B, an antigen derived from microorganisms, a hapten, a drug of abuse, a therapeutic drug, an environmental agent, or antigens specific to Hepatitis.
15. The method of Claim 14, wherein the analyte is bacteria, yeast, fungus or virus.
16. The method of Claim 1, wherein the receptor material is selected from antigens, antibodies, oligonucleotides, chelators, enzymes, bacteria, yeasts, fungi, viruses, bacterial pili, bacterial flagellar materials, nucleic acids, polysaccharides, lipids, proteins, carbohydrates, metals, hormones or receptors for said materials.
17. The method of Claim 1, further comprising a layer of diffraction enhancing elements on the analyte-specific receptor layer, wherein the diffraction enhancing element has a receptor material thereon that is specific for the analyte; wherein the wicking agent is placed on the layer of diffraction enhancing elements.
18. The method of Claim 17, wherein the diffraction enhancing element is selected from glass, cellulose, synthetic polymers or plastics, latex, polystyrene, polycarbonate, bacterial or fungal cells.
19. The method of Claim 17, wherein the diffraction enhancing element is polystyrene latex microspheres.
20. The method of Claim 1, further comprising the step of applying a blocking material to the non-printed areas of the polymer film.
21. The method of Claim 20, wherein the blocking material is selected from .beta.-casein, an albumin, a surfactant, polyethylene glycol, polyvinyl alcohol, or derivatives thereof.
22. The method of Claim 1, wherein the sensing device further comprises a layer of blocking material on the polymer film through which the analyte-specific receptor material is printed.
23. The method of Claim 22, wherein the blocking material is selected from .beta.-casein, an albumin, a surfactant, polyethylene glycol, polyvinyl alcohol, or derivatives thereof.
24. The method of Claim 1, wherein the wicking agent is removed before transmitting the light through the polymer film to detect the presence of the analyte.
25. The method of Claim 1, wherein the wicking agent has a hole in its center and the light is transmitted through the hole in the wicking agent and through the polymer film to detect the presence of the analyte.
26. A method of detecting an analyte in a medium comprising:
contacting the medium with a sensing device, the sensing device comprising:
a) a polymer film;
b) an analyte-specific receptor layer printed in a pattern onto the polymer film wherein the analyte-specific receptor layer has a receptor material thereon that is specific for the analyte;
c) a wicking agent on the analyte-specific receptor layer;
reflecting a light source through the wicking agent and off a surface of the metal-coated polymer film; and detecting presence of the analyte by detecting a pattern formed by diffraction of the reflected light.
27. The method Claim 26, wherein the analyte-specific receptor layer is printed in a pattern such that when the sensing device binds an analyte, the sensing device diffracts reflected light to form a diffraction pattern.
28. The method of Claim 27, wherein the diffraction pattern is visible to an unaided eye.
29. The method of Claim 26, wherein the metal is selected from gold, silver, chromium, nickel, platinum, aluminum, iron, copper, gold oxide, chromium oxide or zirconium.
30. The method of Claim 29, wherein the metal is gold.
31. The method of Claim 30, wherein the gold coating is between approximately 1 nanometer and 1000 nanometers in thickness.
32. The method of Claim 26, wherein the polymer film is selected from polyethylene-terephthalate, acrylonitrile-butadiene-styrene, acrylonitrile-methyl acrylate copolymer, cellophane, cellulosic polymers such as ethyl cellulose, cellulose acetate, cellulose acetate butyrate, cellulose propionate, cellulose triacetate, polyethylene, polyethylene-vinyl acetate copolymers, ionomers (ethylene polymers) polyethylene-nylon copolymers, nylon, polypropylene, methyl pentene polymers, polyvinyl fluoride, or aromatic polysulfones.
33. The method of Claim 32, wherein the polymer film is polyethylene-terephthalate.
34. The method of Claim 26, wherein the wicking agent is selected from a nitrocellulose membrane, a cellulose acetate membrane, or a glass microfiber structure.
35. The method of Claim 26, wherein the analyte is selected from bacteria, yeast, fungus, virus, rheumatoid factor, IgG, IgM, IgA and IgE antibodies, carcinoembryonic antigen, streptococcus Group A antigen, viral antigens, antigens associated with autoimmune disease, allergens, tumor antigens, streptococcus Group B antigen, HIV I or HIV II antigen, antibodies viruses, antigens specific to RSV,, an antibody, antigen, enzyme, hormone, polysaccharide, protein, lipid, carbohydrate, drug or nucleic acid, Neisseria meningitides groups A, B, C, Y and W sub 135, Streptococcus pneumoniae, E. coli K1, Haemophilus influenza type B, an antigen derived from microorganisms, a hapten, a drug of abuse, a therapeutic drug, an environmental agent, or antigens specific to Hepatitis.
36. The method of Claim 35, wherein the analyte is bacteria, yeast, fungus or virus.
37. The method of Claim 26, wherein the receptor material is selected from antigens, antibodies, oligonucleotides, chelators, enzymes, bacteria, yeasts, fungi, viruses, bacterial pili, bacterial flagellar materials, nucleic acids, polysaccharides, lipids, proteins, carbohydrates, metals, hormones or receptors for said materials.
38. The method of Claim 26, further comprising a layer of diffraction enhancing elements on the analyte-specific receptor layer, wherein the diffraction enhancing element has a receptor material thereon that is specific for the analyte; wherein the wicking agent is placed on the layer of diffraction enhancing elements.
39. The method of Claim 38, wherein the diffraction enhancing element is selected from glass, cellulose, synthetic polymers or plastics, latex, polystyrene, polycarbonate, bacterial or fungal cells.
40. The method of Claim 38, wherein the diffraction enhancing element is polystyrene latex microspheres.
41. The method of Claim 26, further comprising the step of applying a blocking material to the non-printed areas of the metal-coated polymer film.
42. The method of Claim 41, wherein the blocking material is selected from .beta.-casein, an albumin, a surfactant, polyethylene glycol, polyvinyl alcohol, or derivatives thereof.
43. The method of Claim 26, wherein' the sensing device further comprises a layer of blocking material on the metal-coated polymer film through which the analyte-specific receptor material is printed.
44. The method of Claim 43, wherein the blocking material is selected from .beta.-casein, an albumin, a surfactant, polyethylene glycol, polyvinyl alcohol, or derivatives thereof.
45. The method of Claim 26, wherein the pattern formed is a holographic pattern.
46. The method of Claim 26, wherein the wicking agent is removed before reflecting the light through the polymer film to detect the presence of the analyte.
47. The method of Claim 26, wherein the wicking agent has a hole in its center and the light is reflected through the hole in the wicking agent and through the polymer film to detect the presence of the analyte.
CA2393982A 1999-12-17 2000-12-12 Use of wicking agent to eliminate wash steps for optical diffraction-based biosensors Expired - Fee Related CA2393982C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US09/465,921 US6399295B1 (en) 1999-12-17 1999-12-17 Use of wicking agent to eliminate wash steps for optical diffraction-based biosensors
US09/465,921 1999-12-17
PCT/US2000/042768 WO2001044813A2 (en) 1999-12-17 2000-12-12 Use of wicking agent to eliminate wash steps for optical diffraction-based biosensors

Publications (2)

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CA2393982A1 true CA2393982A1 (en) 2001-06-21
CA2393982C CA2393982C (en) 2011-11-01

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US (1) US6399295B1 (en)
EP (1) EP1238277B1 (en)
KR (1) KR100734977B1 (en)
CN (1) CN1203318C (en)
AT (1) ATE397216T1 (en)
AU (1) AU779211B2 (en)
CA (1) CA2393982C (en)
DE (1) DE60039066D1 (en)
MX (1) MXPA02005913A (en)
TW (1) TWI247893B (en)
WO (1) WO2001044813A2 (en)

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