CA2382840A1 - Improved topical compositions containing probiotic bacteria, spores, and extracellular products and uses thereof - Google Patents

Improved topical compositions containing probiotic bacteria, spores, and extracellular products and uses thereof Download PDF

Info

Publication number
CA2382840A1
CA2382840A1 CA002382840A CA2382840A CA2382840A1 CA 2382840 A1 CA2382840 A1 CA 2382840A1 CA 002382840 A CA002382840 A CA 002382840A CA 2382840 A CA2382840 A CA 2382840A CA 2382840 A1 CA2382840 A1 CA 2382840A1
Authority
CA
Canada
Prior art keywords
bacillus
composition
species
article
oligosaccharide
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA002382840A
Other languages
French (fr)
Other versions
CA2382840C (en
Inventor
Sean Farmer
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Ganeden Biotech Inc
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2382840A1 publication Critical patent/CA2382840A1/en
Application granted granted Critical
Publication of CA2382840C publication Critical patent/CA2382840C/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N63/00—Biocides, pest repellants or attractants, or plant growth regulators containing microorganisms, viruses, microbial fungi, animals or substances produced by, or obtained from, microorganisms, viruses, microbial fungi or animals, e.g. enzymes or fermentates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4178—1,3-Diazoles not condensed 1,3-diazoles and containing further heterocyclic rings, e.g. pilocarpine, nitrofurantoin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7028—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
    • A61K31/7034—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin
    • A61K31/704—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin attached to a condensed carbocyclic ring system, e.g. sennosides, thiocolchicosides, escin, daunorubicin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7048—Compounds having saccharide radicals and heterocyclic rings having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin, digitoxin or digoxin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/36—Skin; Hair; Nails; Sebaceous glands; Cerumen; Epidermis; Epithelial cells; Keratinocytes; Langerhans cells; Ectodermal cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/66—Microorganisms or materials therefrom
    • A61K35/74—Bacteria
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/66—Microorganisms or materials therefrom
    • A61K35/74—Bacteria
    • A61K35/741—Probiotics
    • A61K35/742—Spore-forming bacteria, e.g. Bacillus coagulans, Bacillus subtilis, clostridium or Lactobacillus sporogenes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/44—Oils, fats or waxes according to two or more groups of A61K47/02-A61K47/42; Natural or modified natural oils, fats or waxes, e.g. castor oil, polyethoxylated castor oil, montan wax, lignite, shellac, rosin, beeswax or lanolin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
    • A61K8/73—Polysaccharides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/92—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof
    • A61K8/925—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof of animal origin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
    • A61K8/99—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from microorganisms other than algae or fungi, e.g. protozoa or bacteria
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0014—Skin, i.e. galenical aspects of topical compositions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0034—Urogenital system, e.g. vagina, uterus, cervix, penis, scrotum, urethra, bladder; Personal lubricants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0046—Ear
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
    • A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
    • A61L15/36—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing microorganisms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/02—Local antiseptics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A61Q19/001—Preparations for care of the lips
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Abstract

The present invention discloses compositions derived from an isolated Bacillus species, spores, or an extracellular product of Bacillus coagulans comprising a supernatant or filtrate of a culture of said Bacillus coagulans strain, suitable for topical application to the skin or mucosal membranes of a mammal, which are utilized to inhibit the growth of bacterium, yeast, fungi, virus, and combinations thereof. The present invention also discloses methods of treatment and therapeutic systems for inhibiting the growth of bacterium, yeast, fungi, virus, and combinations thereof, by topical application of therapeutic compositions which are comprised, in part, of isolated Bacillus species, spores, or an extracellular product of Bacillus coagulans comprising a supernatant or filtrate of a culture of saidBacillus coagulans strain. In addition, the present invention also discloses compositions, methods of treatment, and therapeutic systems for inhibiting the growth of bacterium, yeast, fungi, virus, and combinations thereof, comprising an extracellular product of Pseudomonas lindbergii comprising a supernantant or filtrate of a culture of said Pseudomonas lindbergii strain.

Claims (79)

1. A composition comprising a Bacillus species in a pharmaceutically-acceptable carrier suitable for topical application to skin or a mucous membrane of a mammal.
2. The composition of claim 1, wherein the Bacillus species is included in said composition in a form selected from a group consisting of: vegetative cells, a dried bacterial cell mass, a flowable concentrate, a stabilized gel, a stabilized paste, and spores.
3. The composition of claim 1 wherein said Bacillus species is selected from the group consisting o~ Bacillus coagulans, Bacillus subtilis, Bacillus uniflagellatus, Bacillus lateropsorus, Bacillus laterosporus BOD, Bacillus megaterium, Bacillus polymyxa, Bacillus licheniformis, Bacillus pumilus, and Bacillus sterothermophilus.
4. The composition of claim 1 wherein said Bacillus species is Bacillus coagulans.
5. The composition of claim 1, wherein said composition contains approximately 1x103 to 1x1012 viable vegetative bacterium or spores per gram of composition.
6. The composition of claim 1, further comprising an effective amount of a bifidogenic oligosaccharide.
7. The composition of claim 1, further comprising an effective amount of a bifidogenic oligosaccharide, wherein said bifidogenic oligosaccharide is a fructo-oligosaccharide (FOS).
8. The composition of claim 1, further comprising an effective amount of a bifidogenic oligosaccharide, wherein said bifidogenic oligosaccharide is a fructo-oligosaccharide (FOS) which is present in a concentration ranging from approximately 10 milligrams to 1000 milligrams per gram of composition.
9. The composition of claim 1, further comprising an effective amount of a bifidogenic oligosaccharide, wherein said bifidogenic oligosaccharide is a fructo-oligosaccharide (FOS) which is present in a concentration ranging from approximately 100 milligrams to S00 milligrams per gram of composition.
10. The composition of claim 1, wherein said carrier is selected from a group consisting of:
an emulsion, cream, lotion, gel, oil, ointment, suspension, aerosol spray, powder, aerosol powder, or semi-solid formulation.
11. The composition of claim 1, which further comprises approximately 0.5 % to approximately 99.9% Emu Oil, by weight.
12. A composition comprising an extracellular product of a Bacillus coagulans strain in a pharmaceutically-acceptable carrier which is suitable for topical application to skin or a mucous membrane of a mammal.
13. The composition of claim 12, wherein said extracellular product is a hydrophilic supernatant or filtrate of a culture of a Bacillus coagulans strain fractionated using a method selected from the group consisting of: sub-micron filtration, ion exchange chromatography, and High Performance Liquid Chromatography (HPLC).
14. The composition of claim 12, wherein said carrier is selected from a group consisting of: an emulsion, cream, lotion, gel, oil, ointment, suspension, aerosol spray, powder, aerosol powder or semi-solid formulation.
15. The composition of claim 12, which further comprises Emu Oil.
16. A composition comprising an extracellular product of Pseudomonas lindbergii strain in a pharmaceutically-acceptable carrier which is suitable for topical application to skin or a mucous membrane of a mammal.
17. The composition of claim 16, wherein said extracellular product is a hydrophilic supernatant or filtrate of a culture of a Pseudomonas lindbergii strain fractionated using a method selected from the group consisting of: sub-micron filtration, ion exchange chromatography, and High Performance Liquid Chromatography (HPLC).
18. The composition of claim 16, wherein said carrier is selected from a group consisting of: an emulsion, cream, lotion, gel, oil, ointment, suspension, aerosol spray, powder, aerosol powder or semi-solid formulation.
19. The composition of claim 16, which further comprises Emu Oil.
20. A method of preventing bacterial, yeast, fungal or viral infection comprising: applying topically to skin or a mucous membrane of a mammal a composition comprising a Bacillus species; and allowing the Bacillus species to grow topically for sufficient time to inhibit growth of bacteria, yeast, fungus or virus.
21. The method of claim 20, wherein the Bacillus species is included in said composition in a form selected from a group consisting of: vegetative cells, a dried bacterial cell mass, a flowable concentrate, a stabilized gel, a stabilized paste, and spores.
22. The method of claim 20, wherein said Bacillus species is selected from the group consisting of: Bacillus coagulans, Bacillus subtilis, Bacillus uniflagellatus, Bacillus lateropsorus, Bacillus laterosporus BOD, Bacillus megaterium, Bacillus polymyxa, Bacillus licheniformis, Bacillus pumilus, and Bacillus sterothermophilus.
23. The method of claim 20, wherein said Bacillus species is Bacillus coagulans.
24. The method of claim 20, wherein said composition contains approximately 1x10 3 to 1x10 12 viable bacterium or spores per gram of composition.
25. The method of claim 20, wherein said administering comprises applying from approximately 1x10 8 to 1x10 10 viable bacterium or spores per day.
26. The method of claim 20, wherein said administering comprises applying from approximately 5x10 8 to 1x10 10 viable bacterium or spores per day.
27. The method of claim 20, further comprising an effective amount of a bifidogenic oligosaccharide.
28. The method of claim 20, further comprising an effective amount of a bifidogenic oligosaccharide, wherein said bifidogenic oligosaccharide is a fructo-oligosaccharide (FOS) which is present in a concentration ranging from approximately 10 milligrams to 1000 milligrams per gram of composition.
29. The method of claim 20, further comprising an effective amount of a bifidogenic oligosaccharide, wherein said bifidogenic oligosaccharide is a fructo-oligosaccharide (FOS) which is present in a concentration ranging from approximately 100 milligrams to 500 milligrams per gram of composition.
30. The method of claim 20, wherein the applying step comprises applying a probiotic composition in the form of a cream, lotion, gel, oil, ointment, suspension, aerosol spray, powder, aerosol powder, or semi-solid formulation.
31. A method of inhibiting growth of bacteria, yeast, fungus, virus or a combination thereof, comprising applying topically to skin or a mucous membrane a composition comprising an extracellular product of a Bacillus coagulans strain, and allowing the composition to be present for sufficient time to inhibit growth of bacteria, yeast, fungus, virus or any combination thereof.
32. The method of claim 31, wherein said extracellular product is a hydrophilic supernatant or filtrate of a culture of a Bacillus coagulans strain fractionated using a method selected from the group consisting of: sub-micron filtration, ion exchange chromatography, and High Performance Liquid Chromatography (HPLC).
33. The method of claim 31, wherein the applying step comprises applying the composition in the form of a cream, lotion, gel, oil, ointment, suspension, aerosol spray, powder, aerosol powder or semi-solid formulation.
34. The method of claim 31, wherein said composition further comprises Emu Oil.
35. A method of inhibiting growth of bacteria, yeast, fungus, virus or a combination thereof, comprising applying topically to skin or a mucous membrane a composition comprising an extracellular product of a Pseudomonas lindbergii strain; and allowing the composition to be present for sufficient time to inhibit growth of bacteria, yeast, fungus, virus, or any combination thereof.
36. The method of claim 35, wherein said extracellular product is a hydrophilic supernatant or filtrate of a culture of a Pseudomonas lindbergii strain fractionated using a method selected from the group consisting of: sub-micron filtration, ion exchange chromatography, and High Performance Liquid Chromatography (HPLC).
37. The method of claim 35, wherein the applying step comprises applying the composition in the form of a cream, lotion, gel, oil, ointment, suspension, aerosol spray, powder, aerosol powder, or semi-solid formulation.
38. The method of claim 35, wherein said composition further comprises Emu Oil.
39. An article of manufacture comprising a flexible article and an effective amount of a Bacillus species applied to said flexible article, wherein said flexible article is intended to be worn by or attached to skin or a mucous membrane of a mammal so as to allow probiotic activity of the isolated Bacillus species to occur adjacent to or on the skin or mucous membrane.
40. The article of manufacture of claim 39, wherein the Bacillus species is included in said composition in a form selected from a group consisting o~ vegetative cells, a dried bacterial cell mass, a flowable concentrate, a stabilized gel, a stabilized paste, and spores which are capable of germinating following said application step.
41. The article of manufacture of claim 39, wherein said Bacillus species is selected from the group consisting of: Bacillus coagulans, Bacillus subtilis, Bacillus uniflagellatus, Bacillus lateropsorus, Bacillus laterosporus BOD, Bacillus megaterium, Bacillus polymyxa, Bacillus licheniformis, Bacillus pumilus, and Bacillus sterothermophilus.
42. The article of manufacture of claim 39, wherein said Bacillus species is Bacillus coagulans.
43. The article of manufacture of claim 39, wherein said effective amount is approximately 1x10 3 to 1x10 12 viable vegetative bacterium or spores per article.
44. The article of manufacture of claim 39, further comprising an effective amount of a bifidogenic oligosaccharide.
45. The article of manufacture of claim 39, further comprising an effective amount of a bifidogenic oligosaccharide, wherein said bifidogenic oligosaccharide is a fructo-oligosaccharide (FOS).
46. The article of manufacture of claim 39, further comprising an effective amount of a bifidogenic oligosaccharide, wherein said bifidogenic oligosaccharide is a fructo-oligosaccharide (FOS) which is present in a concentration ranging from approximately 10 milligrams to 1000 milligrams per gram of composition.
47. The article of manufacture of claim 39, further comprising an effective amount of a bifidogenic oligosaccharide, wherein said bifidogenic oligosaccharide is a fructo-oligosaccharide (FOS) which is present in a concentration ranging from approximately 100 milligrams to 500 milligrams per gram of composition.
48. The article of manufacture of claim 39, wherein said article is selected from the group comprising a bandage, a tampon, a feminine hygiene napkin, or an article of clothing.
49. The method of claim 39, wherein the step of wearing or attaching said Bacillus to the skin or a mucous membrane inhibits growth of one or more microbes selected from the group comprising: Staphylococcus species, Pseudomonas species, Clostridium species, Escherichia coli, Proteus species, Klebsiella species, Gardnereia vaginails, Proponbacterium aches, Aeromonas hydrophia, Candida species, Trichophyton species, Aspergillus species, Acremonium species, Scopulariopis species, Herpes simplex I, Herpes simplex II, and Herpes zoster.
50. An article of manufacture comprising a flexible article and an effective amount of an extracellular product is a supernatant or filtrate of a culture of a Bacillus coagulans strain applied to said flexible article, wherein said flexible article is intended to be worn by or attached to skin or a mucous membrane of a mammal so as to allow the anti-microbial activity of the extracellular product to occur adjacent to or on the skin or mucous membrane.
51. The article of manufacture of claim 50, wherein said extracellular product is a hydrophilic supernatant or filtrate of a culture of a Bacillus coagulans strain fractionated using a method selected from the group consisting of: sub-micron filtration, ion exchange chromatography, and High Performance Liquid Chromatography (HPLC).
52. The article of manufacture of claim 50, wherein said carrier is selected from a group consisting of: an emulsion, cream, lotion, gel, oil, ointment, suspension, aerosol spray, powder, aerosol powder or semi-solid formulation.
53. The article of manufacture of claim 50, which further comprises Emu Oil.
54. The method of claim 50, wherein the step of wearing or attaching said extracellular product of a Bacillus coagulans strain to the skin or a mucous membrane inhibits growth of one or more microbes selected from the group comprising: Staphylococcus species, Pseudomonas species, Clostridium species, Escherichia coli, Proteus species, Klebsiella species, Gardnereia vaginails, Proponbacterium acnes, Aeromonas hydrophia, Candida species, Trichophyton species, Aspergillus species, Acremonium species, Scopulariopis species, Herpes simplex I, Herpes simplex II, and Herpes zoster.
55. An article of manufacture comprising a flexible article and an effective amount of an extracellular product is a supernatant or filtrate of a culture of a Pseudomonas lindbergii strain applied to said flexible article, wherein said flexible article is intended to be worn by or attached to skin or a mucous membrane of a mammal so as to allow the anti-microbial activity of the extracellular product to occur adjacent to or on the skin or mucous membrane.
56. The article of manufacture of claim 55, wherein said extracellular product is a hydrophilic supernatant or filtrate of a culture of a Pseudomonas lindbergii strain fractionated using a method selected from the group consisting of: sub-micron filtration, ion exchange chromatography, and High Performance Liquid Chromatography (HPLC).
57. The article of manufacture of claim 55, wherein said carrier is selected from a group consisting of: an emulsion, cream, lotion, gel, oil, ointment, suspension, aerosol spray, powder, aerosol powder or semi-solid formulation.
58. The article of manufacture of claim 55, which further comprises Emu Oil.
59. The method of claim 55, wherein the step of wearing or attaching said extracellular product of a Pseudomonas lindbergii strain to the skin or a mucous membrane inhibits growth of one or more microbes selected from the group comprising: Staphylococcus species, Pseudomonas species, Clostridium species, Escherichia coli, Proteus species, Klebsiella species, Gardnereia vaginails, Proponbacterium acnes, Aeromonas hydrophia, Candida species, Trichophyton species, Aspergillus species, Acremonium species, Scopulariopis species, Herpes simplex I, Herpes simplex II, and Herpes zoster.
60. A method of inhibiting growth of bacteria, yeast, fungus, virus, or any combination thereof, comprising the following steps:

(a) applying a composition comprising a Bacillus species to a solid surface;

(b) contacting the solid surface with the applied Bacillus species thereon to skin or a mucous membrane of a mammal; and (c) allowing the solid surface to contact the skin or mucous membrane for sufficient time to allow initiation of probiotic activity of the isolated Bacillus species so as to inhibit growth of bacteria, yeast, fungus, virus or a combination thereof, adjacent to or on the skin or mucous membrane of said mammal.
61. The method of claim 60, wherein the solid surface comprises a flexible article selected from the group comprising a diaper, a pliable material for wiping skin or a mucous membrane, a dermal patch, adhesive tape, an absorbent pad, a tampon, or an article of clothing.
62. The method of claim 60, wherein the applying step comprises impregnating said composition into a fibrous or non-fibrous solid matrix.
63. The method of claim 60, wherein said Bacillus species is selected from the group consisting of: Bacillus coagulans, Bacillus subtilis, Bacillus uniflagellatus, Bacillus lateropsorus, Bacillus laterosporus BOD, Bacillus megaterium, Bacillus polymyxa, Bacillus licheniformis, Bacillus pumilus, and Bacillus sterothermophilus.
64. The method of claim 60, wherein the Bacillus species is included in said composition in a form selected from a group consisting of: vegetative cells, a dried bacterial cell mass, a flowable concentrate, a stabilized gel, a stabilized paste, and spores which are capable of germinating following said application step.
65. The method of claim 60, wherein the Bacillus species is included in the composition in the form of an extracellular product comprising a hydrophilic supernatant or filtrate of a culture of said Bacillus coagulans strain fractionated using a method selected from the group consisting of sub-micron filtration, ion exchange chromatography, and High Performance Liquid Chromatography (HPLC).
66. The method of claim 60, wherein said composition contains approximately 1x10 3 to 1x10 12 viable bacterium or spores per gram of composition.
67. The method of claim 60, further comprising an effective amount of a bifidogenic oligosaccharide.
68. The method of claim 60, further comprising an effective amount of a bifidogenic oligosaccharide, wherein said bifidogenic oligosaccharide is a fructo-oligosaccharide (FOS).
69. The method of claim 60, further comprising an effective amount of a bifidogenic oligosaccharide, wherein said bifidogenic oligosaccharide is a fructo-oligosaccharide (FOS) which is present in a concentration ranging from approximately 10 milligrams to 1000 milligrams per gram of composition.
70. The method of claim 60, further comprising an effective amount of a bifidogenic oligosaccharide, wherein said bifidogenic oligosaccharide is a fructo-oligosaccharide (FOS) which is present in a concentration ranging from approximately 100 milligrams to 500 milligrams per gram of composition.
71. The method of claim 60, further comprising Emu Oil.
72. A method of inhibiting growth of bacteria, yeast, fungus, virus, or any combination thereof, comprising the following steps:
(a) applying a composition comprising a Pseudomonas lindbergii strain to a solid surface;
(b) contacting the solid surface with the applied Pseudomonas lindbergii strain thereon to skin or a mucous membrane of a mammal; and (c) allowing the solid surface to contact the skin or mucous membrane for sufficient time to allow initiation of probiotic activity of the isolated Pseudomonas lindbergii strain so as to inhibit growth of bacteria, yeast, fungus, virus or a combination thereof, adjacent to or on the skin or mucous membrane of said mammal.
73. The method of claim 72, wherein the solid surface comprises a flexible article selected from the group comprising a diaper, a pliable material for wiping skin or a mucous membrane, a dermal patch, adhesive tape, an absorbent pad, a tampon, or an article of clothing.
74. The method of claim 72, wherein the applying step comprises impregnating said composition into a fibrous or non-fibrous solid matrix.
75. The method of claim 72, wherein the Pseudomonas lindbergii strain is included in the composition in the form of an extracellular product comprising a hydrophilic supernatant or filtrate of a culture of a Pseudomonas lindbergii strain fractionated using a method selected from the group consisting of sub-micron filtration, ion exchange chromatography, and High Performance Liquid Chromatography (HPLC), in a pharmaceutically-acceptable carrier which is suitable for topical application to skin or a mucous membrane of a mammal.
76. The method of claim 72, further comprising Emu Oil.
77. A therapeutic system for inhibiting growth of bacteria, yeast, fungus, virus, or a combination thereof comprising a container comprising a label and a composition comprising Bacillus according to claim 1, wherein said label comprises instructions for use of the composition for inhibiting said growth.
78. A therapeutic system for inhibiting growth of bacteria, yeast, fungus, virus, or a combination thereof comprising a container comprising a label and a composition comprising an extracellular product of Bacillus coagulans according to claim 12, wherein said label comprises instructions for use of the composition for inhibiting said growth.
79. A therapeutic system for inhibiting growth of bacteria, yeast, fungus, virus, or a combination thereof comprising a container comprising a label and a composition comprising an extracellular product of Pseudomonas lindbergii strain according to claim 16, wherein said label comprises instructions for use of the composition for inhibiting said growth.
CA2382840A 1999-08-26 2000-08-25 Improved topical compositions containing probiotic bacteria, spores, and extracellular products and uses thereof Expired - Lifetime CA2382840C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US09/383,975 US6645506B1 (en) 1997-04-18 1999-08-26 Topical compositions containing extracellular products of Pseudomonas lindbergii and Emu oil
US09/383,975 1999-08-26
PCT/US2000/023300 WO2001013927A2 (en) 1999-08-26 2000-08-25 Improved topical compositions containing probiotic bacteria, spores, and extracellular products and uses thereof

Publications (2)

Publication Number Publication Date
CA2382840A1 true CA2382840A1 (en) 2001-03-01
CA2382840C CA2382840C (en) 2011-05-24

Family

ID=23515538

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2382840A Expired - Lifetime CA2382840C (en) 1999-08-26 2000-08-25 Improved topical compositions containing probiotic bacteria, spores, and extracellular products and uses thereof

Country Status (9)

Country Link
US (6) US6645506B1 (en)
EP (2) EP1212069B1 (en)
JP (1) JP2003507428A (en)
AT (1) ATE308988T1 (en)
AU (1) AU783418B2 (en)
CA (1) CA2382840C (en)
DE (1) DE60023919T2 (en)
ES (1) ES2256036T3 (en)
WO (1) WO2001013927A2 (en)

Families Citing this family (147)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2020959C1 (en) * 1991-10-21 1994-10-15 Игорь Дмитриевич Поляков Vaccine for prevention and treatment of dermatophytoses in animals
US6645506B1 (en) * 1997-04-18 2003-11-11 Ganeden Biotech, Inc. Topical compositions containing extracellular products of Pseudomonas lindbergii and Emu oil
EP0975227B1 (en) * 1997-04-18 2005-11-09 Ganeden Biotech, Inc. Topical use of probiotic bacillus spores to prevent or control microbial infections
US6716435B1 (en) * 1997-04-18 2004-04-06 Ganeden Biotech, Inc. Absorbent product containing absorbent structure and Bacillus coagulans
US7767203B2 (en) 1998-08-07 2010-08-03 Ganeden Biotech, Inc. Methods for the dietary management of irritable bowel syndrome and carbohydrate malabsorption
US6461607B1 (en) * 1998-08-24 2002-10-08 Ganeden Biotech, Inc. Probiotic, lactic acid-producing bacteria and uses thereof
JP2003507437A (en) * 1999-08-26 2003-02-25 ガネデン バイオテック， インコーポレイテッド Use of emu oil, a carrier for antifungal, antibacterial, and antiviral drugs
AU783905B2 (en) * 1999-08-26 2005-12-22 Ganeden Biotech, Inc. Use of emu oil carrier for antifungal, antibacterial, and antiviral medications
US6849256B1 (en) 1999-11-08 2005-02-01 Ganeden Biotech Incorporated Inhibition of pathogens by probiotic bacteria
EP1110555A1 (en) * 1999-12-22 2001-06-27 Societe Des Produits Nestle S.A. Antiadhesive agent for the pathogen flora of the skin
AU2058702A (en) * 2000-10-06 2002-04-15 Nestle Sa Use of probiotic lactic acid bacteria for balancing the skin's immune system
AU2002245181B2 (en) 2000-12-21 2006-06-29 Nektar Therapeutics Pulmonary delivery of polyene antifungal agents
US20070190591A1 (en) * 2001-05-02 2007-08-16 Grech Nigel M Microbial compositions and methods of use in water
US20030124104A1 (en) * 2001-11-05 2003-07-03 Sean Farmer Probiotic compositions
US6878373B2 (en) * 2001-12-03 2005-04-12 Micropure Technologies, Inc. Probiotic composition containing Bacillus cereus RRRL B-30535
US7182943B2 (en) * 2002-05-15 2007-02-27 UNIVERSITé LAVAL Method and system for modulation of microbial cell characteristics
CN1723011A (en) * 2002-06-25 2006-01-18 Wm·雷格利Jr·公司 Breath freshening and oral cleansing product with magnolia bark extract
US7632525B2 (en) * 2002-06-25 2009-12-15 Wm. Wrigley Jr. Company Breath freshening and oral cleansing product with magnolia bark extract in combination with surface active agents
US7595065B2 (en) * 2002-06-25 2009-09-29 Wm. Wrigley Jr. Company Breath freshening and oral cleansing products with synergistic combinations of magnolia bark extract and essential oils
AU2003280960A1 (en) * 2002-07-15 2004-02-02 Alcon, Inc. Pharmaceutical compositions for otic use
WO2004067013A1 (en) * 2003-01-24 2004-08-12 Flora Technology Inc. Compositions and methods for restoring bacterial flora
US7052715B2 (en) * 2003-04-11 2006-05-30 All Natural Fmg, Inc. Alcohol-free transdermal analgesic composition and processes for manufacture and use thereof
US20050019379A1 (en) 2003-07-22 2005-01-27 Kimberly-Clark Worldwide, Inc. Wipe and methods for improving skin health
US7749509B2 (en) * 2003-08-29 2010-07-06 Cobb And Company, Llp Treatment of autism using probiotic composition
US8192733B2 (en) * 2003-08-29 2012-06-05 Cobb & Associates Probiotic composition useful for dietary augmentation and/or combating disease states and adverse physiological conditions
US7731976B2 (en) * 2003-08-29 2010-06-08 Cobb And Company, Llp Treatment of irritable bowel syndrome using probiotic composition
US7759105B2 (en) * 2003-08-29 2010-07-20 Cobb & Company, Llp Probiotic composition useful for dietary augmentation and/or combating disease states and adverse physiological conditions
DE50300325D1 (en) * 2003-11-03 2005-03-31 Peter-Hansen Volkmann Vaginalpflegezusammensetzung
BRPI0418589A (en) 2003-12-08 2008-01-29 Bentley Pharmaceuticals Inc pharmaceutical compositions and methods for insulin treatment
US20050226947A1 (en) * 2004-02-04 2005-10-13 Dale Kern Agents for sequestering serum aging factors and uses therefore
AU2005227234B2 (en) * 2004-03-04 2008-09-04 E-L Management Corporation Skin treatment method with lactobacillus extract
CA2559905A1 (en) * 2004-03-10 2005-09-22 Jeff Hudnall Antimicrobial wax composition for wax therapy
WO2006113925A2 (en) * 2005-04-20 2006-10-26 Health Enhancement Products, Inc. Composition and use of phyto-percolate for treatment of disease
US20050244402A1 (en) * 2004-04-30 2005-11-03 Villanueva Julie M Absorption of pain-causing agents
US7854927B2 (en) * 2004-05-11 2010-12-21 Ganeden Biotech, Inc. Methods and compositions for the dietary management of autoimmune disorders
US7446904B2 (en) * 2004-05-28 2008-11-04 Infoprint Solutions Company, Llc Methods and apparatus for generating dither mask through interpolation between preferred patterns
US7252846B2 (en) * 2004-05-28 2007-08-07 Raied Dinno Topical composition and method for the treatment and prophylaxis of dermal irritations
FR2872047B1 (en) * 2004-06-23 2007-06-15 Oreal COMPOSITION FOR SENSITIVE SKINS COMBINING MINERAL AND PROBIOTIC CATION (S)
JP2008503563A (en) * 2004-06-23 2008-02-07 ロレアル Methods and compositions useful for the prevention and / or treatment of sensitive and / or dry skin
US7704522B2 (en) * 2004-09-08 2010-04-27 Clyde Morgan Topical medicament
AU2005291098B2 (en) * 2004-10-04 2011-11-24 L'oreal Cosmetic and/or dermatological composition for sensitive skins
US8092793B2 (en) * 2004-12-15 2012-01-10 Qingdao East Sea Pharmaceuticals, Ltd. Treating inflammatory bowel disease with live bacteria
WO2006076780A1 (en) * 2004-12-17 2006-07-27 Gielen Cornelis Use of non-pathogenic bacterial strains in cleaning and milking an animal
US20060147507A1 (en) * 2005-01-04 2006-07-06 Marie Cammarata Hot flash treatment system
DE502005010458D1 (en) * 2005-04-28 2010-12-09 Osipova Irina Grigorievna IRILIS BIOPRÄPARATION BASED ON BACILLUS BACTERUS BARS BACILLUS SUBTILIS AND BACILLUS LICHENIFORMIS CONTAINING THEREIN
DE102005020457A1 (en) * 2005-04-29 2006-11-02 Westfaliasurge Gmbh Use of non-pathogenic sporulating bacteria for inhibiting the growth of infectious germs on the udder and/or teat of a lactating mammal
FR2889057B1 (en) * 2005-08-01 2008-07-18 Oreal COSMETIC AND / OR DERMATOLOGICAL COMPOSITION FOR THE PREVENTION AND / OR TREATMENT OF SENSITIVE OR DRY SKINS
US8246946B2 (en) * 2005-09-27 2012-08-21 Cobb & Associates Treatment of bipolar disorder utilizing anti-fungal compositions
US20070092547A1 (en) * 2005-10-24 2007-04-26 Birnbaum Jay E Method for treating/controlling/killing fungi and bacteria
US20080220103A1 (en) * 2005-10-24 2008-09-11 Jay Birnbaum Method for treating/controlling/killing fungi and bacteria on living animals
EP1978979B1 (en) * 2006-01-04 2014-08-13 Wikström, Maude Probiotic oral health promoting product
WO2007139601A2 (en) * 2006-02-21 2007-12-06 Bcr Diagnostics, Inc. Phenotypic engineering of spore
CN101095698B (en) * 2006-06-26 2010-12-01 青岛东海药业有限公司 Use of Clostridium Butyricum for preventing and treating foetid faeces toxin syndrome and disease
US20080031979A1 (en) * 2006-08-04 2008-02-07 Claude Saliou Use of extracts for the treatment of viral disorders
CN103122327B (en) 2006-08-11 2015-11-18 诺维信生物股份有限公司 Bacterial cultures and the composition comprising bacterial cultures
US7858126B2 (en) 2006-08-31 2010-12-28 Trinity Laboratories Inc. Derivatives of sandalwood oil and santalols for treating cold sores and herpes
US20080075680A1 (en) * 2006-09-27 2008-03-27 Chen Jonathan Y Culture of microorganisms endogenous to plants and products thereof
US20080107699A1 (en) * 2006-10-25 2008-05-08 Mark Spigelman Method of using topical probiotics for the inhibition of surface contamination by a pathogenic microorganism and composition therefor
CN101134052A (en) * 2006-11-17 2008-03-05 青岛东海药业有限公司 Application of clostridium butyricum, condensate bacillus and bifidobacteria in the preparation of medicament for preventing and treating mouth ulcer
US20100063004A1 (en) * 2006-12-04 2010-03-11 Ranjan Ray Chaudhuri Topical pharmaceutical composition
FR2914189A1 (en) * 2007-03-26 2008-10-03 Oreal USE OF A LIPOPOLYSACCHARIDE FRACTION OF VITREOSCILLA FILIFORMIS AS AGENT STIMULATING THE SYNTHESIS OF ANTIMICROBIAL PEPTIDES OF THE SKIN.
MX2009011286A (en) 2007-04-19 2010-04-01 Mary Kay Inc Magnolia extract containing compositions.
FR2915388B1 (en) 2007-04-27 2010-12-24 Oreal COSMETIC WATER SOLUBLE FILM
TW200904340A (en) 2007-05-11 2009-02-01 Mannatech Inc Processing of natural polysaccharides by selected non-pathogenic microorganisms and methods of making and using the same
WO2008153377A1 (en) * 2007-06-15 2008-12-18 N.V. Nutricia Nutrition with non-viable bifidobacterium and non-digestible oligosaccharide
FR2919501B1 (en) * 2007-08-02 2010-12-31 Oreal USE OF HESPERIDINE OR ONE OF ITS DERIVATIVES FOR THE PREVENTION AND / OR TREATMENT OF RELEASED SKINS
LT2211626T (en) 2007-08-29 2019-11-11 Ganeden Biotech Inc Baked goods
WO2009031106A2 (en) * 2007-09-04 2009-03-12 L'oreal Use of a combination of hesperidin and of a microorganism for influencing the barrier function of the skin
FR2920305B1 (en) 2007-09-04 2010-07-30 Oreal USE OF A SPECIFIC BIFIDOBACTERIUM LYSATE FOR THE TREATMENT OF SENSITIVE SKINS.
FR2920304B1 (en) * 2007-09-04 2010-06-25 Oreal COSMETIC USE OF LYSAT BIFIDOBACTERIUM SPECIES FOR THE TREATMENT OF DROUGHT.
ES2868135T3 (en) * 2007-10-16 2021-10-21 Ganeden Biotech Inc Drink compositions
US20090107007A1 (en) * 2007-10-31 2009-04-30 Mitchellace, Inc. Insole with included aloe extract
US9314524B2 (en) * 2007-12-31 2016-04-19 Calla Therapeutics Llc Topical formulations of Flucytosine
WO2009099562A2 (en) * 2008-01-30 2009-08-13 Ganeden Biotech, Inc. Compositions and methods for cleaning surfaces
US20090246152A1 (en) * 2008-03-28 2009-10-01 Nu Skin International, Inc. Naractin compositions for the inhibition of reactive oxygen species
US20090246153A1 (en) * 2008-03-28 2009-10-01 Nu Skin International, Inc. Cosmetic compositions for the inhibition of reactive oxygen species
US7788209B2 (en) * 2008-05-05 2010-08-31 United Technologies Corporation Hybrid fault reasoning and guided troubleshooting system that uses case-based reasoning and model-based reasoning
FR2938437B1 (en) * 2008-11-19 2020-03-27 Société des Produits Nestlé S.A. COSMETIC USE OF MICROORGANISM FOR THE TREATMENT OF OILY SKIN
KR101764592B1 (en) * 2008-09-24 2017-08-23 레실럭스 Incorporation of thermo-resistant and/or pressure-resistant organisms in materials
US20100160224A1 (en) * 2008-10-14 2010-06-24 David Thomas Shelf-stable consumable compositions containing probiotic-mimicking elements and methods of preparing and using the same
BR122017003315B1 (en) 2008-10-16 2018-01-16 Ganeden Biotech, Inc. FOOD COMPOSITIONS UNDERSTANDING GRAINS AND ISOLATED SPACES OF BACILLUS COAGULANS, AS WELL AS THEIR PREPARATION METHOD
FR2942719B1 (en) 2009-03-04 2011-08-19 Oreal USE OF PROBIOTIC MICROORGANISMS TO LIMIT SKIN IRRITATION
EP3246039A1 (en) * 2009-04-29 2017-11-22 Ganeden Biotech, Inc. Bacterial cell membrane formulation
US8506952B2 (en) * 2009-07-03 2013-08-13 James Madison Innovations, Inc. Probiotic compositions and process thereof
FR2954140A1 (en) * 2009-12-17 2011-06-24 Oreal COSMETIC OR DERMATOLOGICAL COMPOSITIONS BASED ON BACTERIOCINS AND PREBIOTICS
EP2338331A1 (en) * 2009-12-22 2011-06-29 Research Center Pharmaceutical Engineering GmbH Methods and compositions for biologically controlling microbial growth on clean room equipment
US20110229446A1 (en) * 2010-03-02 2011-09-22 Roman Stephen B Method and composition to relieve sexual discomfort and improve vaginal health
KR20130045855A (en) * 2010-03-12 2013-05-06 칼피스가부시키가이샤 Agent for controlling the increase and decrease of lactobacillus bifidus in colon
US9301982B2 (en) 2010-04-14 2016-04-05 Ganeden Biotech, Inc. Probiotic confection and lipid compositions
US20110318289A1 (en) * 2010-06-24 2011-12-29 Novozymes Biologicals, Inc. Methods and Compositions for Reducing Body Odor
JP2013537431A (en) * 2010-08-25 2013-10-03 テイト アンド ライル イングリーディエンツ アメリカス エルエルシー Symbiotic products
WO2012031186A1 (en) 2010-09-03 2012-03-08 Wisconsin Pharmacal Company, Llc. Prebiotic suppositories
FR2968991B1 (en) * 2010-12-17 2013-01-11 Oreal "USE OF STABLE MICROBIAL POPULATION TO PREVENT AND / OR TREAT THE DISORDERS OF FRAGILIZED OR DAMAGED LIP"
WO2012085255A2 (en) * 2010-12-22 2012-06-28 Research Center Pharmaceutical Engineering Gmbh Volatile organic compounds from bacterial antagonists for controlling microbial growth
CN103476921A (en) 2011-02-15 2013-12-25 诺维信生物股份有限公司 Mitigation of odor in cleaning machines and cleaning processes
US11235008B2 (en) 2011-03-31 2022-02-01 Ganeden Biotech, Inc. Probiotic sports nutrition compositions
US20120255334A1 (en) * 2011-04-08 2012-10-11 Stephen Gans Soluble organic fertilizer
US20120308490A1 (en) * 2011-06-06 2012-12-06 Abr Consulting S.R.L. Method of obtaining a preparation of biological origin for oral hygiene to prevent the onset of tooth decay
US9004374B1 (en) * 2011-07-20 2015-04-14 Stephen Gans Irrigation method using thixotropic materials
CN102643821B (en) * 2012-01-05 2013-11-13 集美大学 Aeromonas hydrophila aptamer, and screening method and application thereof
KR20150008086A (en) 2012-04-20 2015-01-21 헨네핀 라이프 사이언스 Compositions for topical treatment of microbial infections
GB201312713D0 (en) 2013-03-22 2013-08-28 Weaver Connie M Uses of soluble corn fibre for increasing colonic bacteria populations and increasing mineral absorption
US9805171B2 (en) 2013-08-23 2017-10-31 Elwha Llc Modifying a cosmetic product based on a microbe profile
US9390312B2 (en) 2013-08-23 2016-07-12 Elwha Llc Systems, methods, and devices for assessing microbiota of skin
US9811641B2 (en) 2013-08-23 2017-11-07 Elwha Llc Modifying a cosmetic product based on a microbe profile
US10010704B2 (en) 2013-08-23 2018-07-03 Elwha Llc Systems, methods, and devices for delivering treatment to a skin surface
US9456777B2 (en) 2013-08-23 2016-10-04 Elwha Llc Systems, methods, and devices for assessing microbiota of skin
US9557331B2 (en) 2013-08-23 2017-01-31 Elwha Llc Systems, methods, and devices for assessing microbiota of skin
US10152529B2 (en) 2013-08-23 2018-12-11 Elwha Llc Systems and methods for generating a treatment map
US8883747B1 (en) * 2013-10-09 2014-11-11 Craig W. Carver Topical antifungal compositions and methods of use thereof
US9596861B2 (en) * 2013-12-24 2017-03-21 Sami Labs Limited Method of producing partially purified extracellular metabolite products from Bacillus coagulans and biological applications thereof
CN106456531B (en) * 2014-03-31 2019-09-10 路博润先进材料公司 For increasing the bacterium bacterial strain extractive from fermentative of adiponectin levels
CN104946550A (en) * 2014-05-12 2015-09-30 山东黎昊源生物工程有限公司 Leaf-protection biological strain repair agent
TWI702004B (en) 2014-05-13 2020-08-21 美商微生物發現公司 Direct-fed microbials and methods of their use
US10004768B2 (en) * 2014-09-25 2018-06-26 Iryohojin Kiyokai Treatment of atopic dermatitis and infectious dermatitis with biological spa therapy
EA027597B1 (en) * 2014-10-09 2017-08-31 Александр Владимирович Синица Composition with probiotic, hepatoprotective, antioxidant and immune modulating activity
WO2016183535A1 (en) 2015-05-14 2016-11-17 University Of Puerto Rico Methods for restoring microbiota of newborns
CN105132307B (en) * 2015-07-22 2017-12-12 江南大学 It is a kind of applied to the composite bacillus microbial water-purifying agent of ornamental fish and its application
DE102015010874B4 (en) * 2015-08-25 2017-06-14 Fritz Stephan Gmbh Medizintechnik Suit for a newborn, especially a premature baby
AU2016344406B2 (en) * 2015-10-30 2021-09-09 Z Probiotics Inc. Dba Z Bioscience Inc. Probiotic compositions and uses thereof
WO2017117142A1 (en) 2015-12-28 2017-07-06 New York University Device and method of restoring microbiota of newborns
AU2017240069B2 (en) 2016-03-31 2024-03-07 Gojo Industries, Inc. Sanitizer composition with probiotic/prebiotic active ingredient
WO2017173244A1 (en) * 2016-03-31 2017-10-05 Gojo Industries, Inc. Topical composition for reducing pathogen binding
WO2017173240A1 (en) 2016-03-31 2017-10-05 Gojo Industries, Inc. Antimicrobial peptide stimulating cleansing composition
SG11201809100QA (en) * 2016-04-19 2018-11-29 Us Health Use of gram negative species to treat atopic dermatitis
AR108659A1 (en) * 2016-06-03 2018-09-12 Valent Biosciences Llc NON-WATERY, NON-OILY COMPOSITIONS WITH BACILLUS AMYLOLIQUEFACIENS
MX2019002978A (en) * 2016-09-14 2019-09-18 Grace Breeding Ltd Compositions comprising a non-pathogenic bacteria and methods for protecting plant and animal hosts from fungal, bacterial and viral diseases.
BE1024189B1 (en) * 2016-10-28 2017-12-05 Yun NV SPRAYER WITH BACTERIAL SPECIES
EP3544575A1 (en) 2016-11-23 2019-10-02 GOJO Industries, Inc. Sanitizer composition with probiotic/prebiotic active ingredient
IT201700005552A1 (en) * 2017-01-19 2018-07-19 Copma S C A R L EUTROFIZZANTE PRODUCT FOR COSMETIC USE
JP7150753B2 (en) * 2017-06-06 2022-10-11 サミ－サビンサ グループ リミテッド Hair care compositions containing extracellular metabolite preparations derived from Bacillus coagulans
KR102288904B1 (en) * 2017-06-06 2021-08-12 새미 랩스 리미티드 Anti-aging potential of extracellular metabolites isolated from Bacillus coagulans MTCC 5856
US20180344627A1 (en) * 2017-06-06 2018-12-06 Muhammed Majeed Skin care applications of extracellular metabolites from bacillus coagulans
US11253466B2 (en) * 2017-07-28 2022-02-22 Davincia Inc. Topical composition for rejuvenating and/or repairing skin, methods, uses and kits thereof
WO2019049150A1 (en) 2017-09-07 2019-03-14 Technion Research & Development Foundation Limited Topical kits and compositions and use thereof
CA3083777C (en) * 2017-12-04 2024-03-26 Sami Labs Limited Compositions for microbial anti-adhesion
MX2020005875A (en) 2017-12-05 2020-10-08 Bioplx Inc Methods and compositions to prevent microbial infection.
WO2019212379A1 (en) * 2018-05-04 2019-11-07 Farber Boris Slavinovich Food, cosmetic and pharmaceutical formulation with an immunomodulatory and protective anti-viral effect
FR3085687B1 (en) * 2018-09-07 2021-05-14 Nolivade COMPOSITION AND PRESERVATION PROCESS
WO2020072642A1 (en) * 2018-10-02 2020-04-09 Nutech Ventures Novel gras probiotic bacterial strain to inhibit acidosis and liver abscesses in cattle
KR20210100662A (en) * 2018-12-05 2021-08-17 세레스 테라퓨틱스, 인코포레이티드 Compositions for stabilizing bacteria and uses thereof
BR112021012118A2 (en) * 2018-12-19 2021-09-08 Healthy Cow Corporation PROBIOTIC COMPOSITION IN GEL FORM, READY-TO-USE PROBIOTIC PRODUCT, KIT, SYSTEM, AND METHODS FOR INTRODUCING ONE OR MORE STRAINS OF BACTERIA INTO THE VAGINA OF A NON-HUMAN ANIMAL, TO TREAT A UTERINE INFECTION OR TO REDUCE THE RISK OF GETTING A UTERINE INFECTION IN A NON-HUMAN ANIMAL AND TO PROMOTE THE ESTABLISHMENT OR MAINTENANCE OF A HEALTHY VAGINAL MICROBIOME IN A NON-HUMAN ANIMAL
CN109464313A (en) * 2019-01-22 2019-03-15 杭州百芮生物科技有限公司 A kind of preparation method and biology cellulose diaphragm of external preparation for skin Essence
WO2020191173A1 (en) * 2019-03-19 2020-09-24 Microbial Discovery Group, Llc Microbial strains for virus inhibition
CN113699085B (en) * 2021-11-01 2022-02-08 渤海水产科技(滨州)有限公司 Antagonistic bacterium ED5 and application thereof
CN114767936B (en) * 2022-05-10 2023-04-18 武汉理工大学 Preparation method of composite lactobacillus casei bracket material for repairing skin injury
CN115074286B (en) * 2022-07-01 2023-06-06 安徽农业大学 Bacillus pumilus for antagonizing tinea pedis pathogenic fungi and application thereof

Family Cites Families (41)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL7401939A (en) * 1974-02-13 1975-08-15 Philips Nv LOAD-CONNECTED DEVICE.
US4062943A (en) * 1974-11-20 1977-12-13 Board Of Supervisors Louisiana State University A & M Antibiotic produced from the microorganism (Pseudomonas lindbergii), its preparation and method of use
US4323651A (en) * 1974-12-04 1982-04-06 R. J. Reynolds Tobacco Company Thermostable lactase derived from bacillus
JPS52102419A (en) * 1976-02-23 1977-08-27 Seikenkai Lactic acid producing bacillus preparation
US4110477A (en) 1977-05-13 1978-08-29 Kabushiki Kaisha Naruse Fermentation Laboratory Method for producing natto containing lactic acid bacteria
JPS55113718A (en) * 1979-02-27 1980-09-02 Yakult Honsha Co Ltd Antitumor agent
IE59628B1 (en) * 1986-06-26 1994-03-09 Beecham Group Plc Treatment of fungal infections
US5413960A (en) * 1987-05-01 1995-05-09 Biogaia Ab Antibiotic reuterin
JPH01199575A (en) * 1988-02-04 1989-08-10 Rikagaku Kenkyusho Novel cyclomaltodextrin-glucano transferase and production thereof
IT1227154B (en) 1988-08-05 1991-03-19 A Tosi Farmaceutici S R L Nova PHARMACEUTICAL COMPOSITIONS FOR GYNECOLOGICAL USE BASED ON LATTOBACILLI
AT391323B (en) 1989-03-10 1990-09-25 Jungbunzlauer Ag MICROORGANISM OF THE SPECIES BACILLUS COAGULANS AND A METHOD FOR THE PRODUCTION OF OPTICALLY PURE L (+) - LACTIC ACID
US5371011A (en) * 1989-07-10 1994-12-06 Zeneca Corp. Mold control in forage
FR2656314B1 (en) * 1989-12-22 1992-04-17 Bp Chemicals Snc ZIRCONIUM CATALYST SUPPORTED ON MAGNESIUM CHLORIDE, PROCESS FOR THE PREPARATION AND USE OF THE CATALYST IN OLEFIN POLYMERIZATION.
DE4001611C1 (en) * 1990-01-20 1991-02-28 Skw Trostberg Ag, 8223 Trostberg, De
US5200336A (en) * 1990-07-02 1993-04-06 New England Biolabs, Inc. Restriction endonuclease obtainable foam bacillus coagulans and a process for producing the same
US5431924A (en) * 1990-11-14 1995-07-11 Emu Products Western Australia Pty. Ltd. Anti-inflammatory composition derived from emu oil
IT1262927B (en) 1992-01-14 1996-07-22 Consiglio Nazionale Ricerche EXTENDING BACTERIA AND THEIR USE AS PROBIOTICS
FI92498C (en) * 1992-06-10 1994-11-25 Valio Meijerien New microorganism strain, bacterial preparations containing it and their use for controlling yeast and mold
JPH06166623A (en) * 1992-09-25 1994-06-14 Toyama Chem Co Ltd Antimicrobial composition
WO1994011492A1 (en) 1992-11-12 1994-05-26 Chr. Hansen's Laboratory, Inc. Method of favorably modifying poultry intestinal microflora
US6103246A (en) * 1993-06-03 2000-08-15 Tisdale; Carrie J. Creams and lotions containing emu oil
US5540920A (en) * 1994-11-22 1996-07-30 Olin Corporation Synergistic biocide composition containing pyrithione plus an additive
US5472713A (en) * 1994-11-23 1995-12-05 Elf Resources, Inc. Therapeutic uses of emu oil
SE9502588L (en) 1995-07-13 1997-01-14 Moelnlycke Ab Inhibition of the growth of bacteria in connection with absorbent products by the addition of other bacteria
US5698227A (en) * 1996-07-23 1997-12-16 Rivlin; Daniel Compositions comprising lidocaine and emu oil and methods of use thereof
US6645506B1 (en) * 1997-04-18 2003-11-11 Ganeden Biotech, Inc. Topical compositions containing extracellular products of Pseudomonas lindbergii and Emu oil
EP0975227B1 (en) * 1997-04-18 2005-11-09 Ganeden Biotech, Inc. Topical use of probiotic bacillus spores to prevent or control microbial infections
ATE407687T1 (en) * 1997-06-03 2008-09-15 Ganeden Biotech Inc PROBIOTIC LACTIC ACID BACTERIA FOR THE TREATMENT OF BACTERIAL INFECTIONS RELATED TO SIDS
US7374753B1 (en) * 1997-06-03 2008-05-20 Ganeden Biotech, Inc. Probiotic lactic acid bacterium to treat bacterial infections associated with SIDS
US6261577B1 (en) * 1997-07-16 2001-07-17 Symbollon Corporation Non-staining topical iodine composition and method
US6312703B1 (en) * 1998-02-06 2001-11-06 Lecigel, Llc Compressed lecithin preparations
US6811786B1 (en) * 1999-04-01 2004-11-02 Ganeden Biotech, Inc. Methods for reducing cholesterol using Bacillus coagulans spores, systems and compositions
JP2002522393A (en) 1998-08-07 2002-07-23 ガネデン バイオテック， インコーポレイテッド Method for increasing the solubility of nutrient materials using symbiotic lactic acid producing bacteria
US6461607B1 (en) 1998-08-24 2002-10-08 Ganeden Biotech, Inc. Probiotic, lactic acid-producing bacteria and uses thereof
EP1173233A1 (en) 1999-04-14 2002-01-23 Ganeden Biotech, Inc. Methods for inhibiting microbial infections associated with sanitary products
JP2003507437A (en) * 1999-08-26 2003-02-25 ガネデン バイオテック， インコーポレイテッド Use of emu oil, a carrier for antifungal, antibacterial, and antiviral drugs
US6849256B1 (en) * 1999-11-08 2005-02-01 Ganeden Biotech Incorporated Inhibition of pathogens by probiotic bacteria
US6416772B1 (en) * 2001-01-12 2002-07-09 H. Wayne Van Engelen Topical dermal anaesthetic
US20030124104A1 (en) * 2001-11-05 2003-07-03 Sean Farmer Probiotic compositions
US20030143262A1 (en) * 2001-12-13 2003-07-31 Brusk Ulla Forsgren Hygiene tissue
US6579543B1 (en) * 2002-02-22 2003-06-17 Jackie H. McClung Composition for topical application to skin

Also Published As

Publication number Publication date
US7541042B2 (en) 2009-06-02
US6905692B2 (en) 2005-06-14
US6723326B1 (en) 2004-04-20
WO2001013927A3 (en) 2001-08-30
AU7332400A (en) 2001-03-19
DE60023919T2 (en) 2006-08-10
US7807185B2 (en) 2010-10-05
AU783418B2 (en) 2005-10-27
US7544363B2 (en) 2009-06-09
WO2001013927A9 (en) 2002-07-11
ATE308988T1 (en) 2005-11-15
US20050271758A1 (en) 2005-12-08
US20080089963A1 (en) 2008-04-17
CA2382840C (en) 2011-05-24
WO2001013927A2 (en) 2001-03-01
JP2003507428A (en) 2003-02-25
US6645506B1 (en) 2003-11-11
DE60023919D1 (en) 2005-12-15
US20090238907A1 (en) 2009-09-24
US20030003107A1 (en) 2003-01-02
EP1212069A2 (en) 2002-06-12
EP1632239A1 (en) 2006-03-08
EP1212069B1 (en) 2005-11-09
ES2256036T3 (en) 2006-07-16

Similar Documents

Publication Publication Date Title
CA2382840A1 (en) Improved topical compositions containing probiotic bacteria, spores, and extracellular products and uses thereof
US6716435B1 (en) Absorbent product containing absorbent structure and Bacillus coagulans
DE69832267D1 (en) SURFACE USE OF PROBIOTIC BACILLUS SPORES TO PREVENT OR PREVENT MICROBIAL INFECTIONS
AU780367B2 (en) Methods for inhibiting microbial infections associated with sanitary products
US7507402B1 (en) Topical use of probiotic Bacillus spores to prevent or control microbial infections
EP0594628B1 (en) Tampon or sanitary napkin provided with lactic acid producing bacteria
US20100215707A1 (en) Activated creatinine and precursors thereof as antibacterial agents, compositions and products containing such agents and uses thereof
CA2305739A1 (en) Product and preparation containing lactic acid bacteria
DE60012026D1 (en) USE OF EMU OIL AS A CARRIER FOR FUNGICIDES, ANTIBACTERIAL AND ANTIVIRAL MEDICINES
US6224896B1 (en) Composition and process for the treatment of epidermal traumas such as decubitus ulcers
AU6924698A (en) Use of at least an irvingia gabonensis extract in a cosmetic and/or pharmaceutical product
CA2449910C (en) Use of glycoprotein for the treatment and re-epithelialisation of wounds
EP0498532A1 (en) Necrotic tissue debridement powder composition containing a proteolytic enzyme
US20130243847A1 (en) Activated creatinine and precursors thereof as antibacterial agents, compositions and products containing such agents and use thereof
US4847084A (en) Ointment for the treatment of decubiti ulcers
GB2094623A (en) Compositions containing hydrogen peroxide
Müller Zur Ökologie von Staphylococcus aureus auf der menschlichen Hautoberfläche
CA1258228A (en) Enzymatic bandages and pads
KR20210057501A (en) Composition for inhibiting microbial growth comprising 1,2-hexanediol and glyceryl caprylate

Legal Events

Date Code Title Description
EEER Examination request
MKEX Expiry

Effective date: 20200825