CA2376285A1 - Intracutaneous microneedle array apparatus - Google Patents

Intracutaneous microneedle array apparatus Download PDF

Info

Publication number
CA2376285A1
CA2376285A1 CA002376285A CA2376285A CA2376285A1 CA 2376285 A1 CA2376285 A1 CA 2376285A1 CA 002376285 A CA002376285 A CA 002376285A CA 2376285 A CA2376285 A CA 2376285A CA 2376285 A1 CA2376285 A1 CA 2376285A1
Authority
CA
Canada
Prior art keywords
fluid
microneedle array
dermis
array apparatus
skin
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA002376285A
Other languages
French (fr)
Other versions
CA2376285C (en
Inventor
Vadim Vladimirovich Yuzhakov
Faiz F. Sherman
Grover David Owens
Vladimir Gartstein
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Corium Inc
Original Assignee
Vadim Vladimirovich Yuzhakov
Faiz F. Sherman
Grover David Owens
Vladimir Gartstein
The Procter & Gamble Company
Corium International Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Vadim Vladimirovich Yuzhakov, Faiz F. Sherman, Grover David Owens, Vladimir Gartstein, The Procter & Gamble Company, Corium International Inc. filed Critical Vadim Vladimirovich Yuzhakov
Publication of CA2376285A1 publication Critical patent/CA2376285A1/en
Application granted granted Critical
Publication of CA2376285C publication Critical patent/CA2376285C/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B81—MICROSTRUCTURAL TECHNOLOGY
    • B81C—PROCESSES OR APPARATUS SPECIALLY ADAPTED FOR THE MANUFACTURE OR TREATMENT OF MICROSTRUCTURAL DEVICES OR SYSTEMS
    • B81C99/00—Subject matter not provided for in other groups of this subclass
    • B81C99/0075—Manufacture of substrate-free structures
    • B81C99/0085—Manufacture of substrate-free structures using moulds and master templates, e.g. for hot-embossing
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/20—Applying electric currents by contact electrodes continuous direct currents
    • A61N1/30—Apparatus for iontophoresis, i.e. transfer of media in ionic state by an electromotoric force into the body, or cataphoresis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
    • A61M2037/0023—Drug applicators using microneedles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
    • A61M2037/003—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles having a lumen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
    • A61M2037/0053—Methods for producing microneedles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
    • A61M2037/0061—Methods for using microneedles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
    • A61M5/168—Means for controlling media flow to the body or for metering media to the body, e.g. drip meters, counters ; Monitoring media flow to the body
    • A61M5/172—Means for controlling media flow to the body or for metering media to the body, e.g. drip meters, counters ; Monitoring media flow to the body electrical or electronic
    • A61M5/1723—Means for controlling media flow to the body or for metering media to the body, e.g. drip meters, counters ; Monitoring media flow to the body electrical or electronic using feedback of body parameters, e.g. blood-sugar, pressure
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B81—MICROSTRUCTURAL TECHNOLOGY
    • B81B—MICROSTRUCTURAL DEVICES OR SYSTEMS, e.g. MICROMECHANICAL DEVICES
    • B81B2201/00—Specific applications of microelectromechanical systems
    • B81B2201/05—Microfluidics
    • B81B2201/055—Microneedles

Abstract

The present invention relates generally to medical devices and is particularly directed to a fluid dispensing device and a fluid sampling device of the type which, in one embodiment penetrates the stratum corneum and epidermis, but not into the dermis of skin, and in another embodiment penetrates into the dermis so as to interface with blood or other biological fluids. The invention is specifically disclosed as an array of microneedles which painlessly and with minimal trauma to the skin enable fluid transfer either into a body as a dispensing device, or from the body to sample body fluid.
CA002376285A 1999-06-09 2000-06-07 Intracutaneous microneedle array apparatus Expired - Fee Related CA2376285C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US09/329,025 1999-06-09
US09/329,025 US6256533B1 (en) 1999-06-09 1999-06-09 Apparatus and method for using an intracutaneous microneedle array
PCT/US2000/015613 WO2000074765A1 (en) 1999-06-09 2000-06-07 Intracutaneous microneedle array apparatus

Publications (2)

Publication Number Publication Date
CA2376285A1 true CA2376285A1 (en) 2000-12-14
CA2376285C CA2376285C (en) 2006-05-09

Family

ID=23283537

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002376285A Expired - Fee Related CA2376285C (en) 1999-06-09 2000-06-07 Intracutaneous microneedle array apparatus

Country Status (7)

Country Link
US (3) US6256533B1 (en)
EP (1) EP1183065B1 (en)
JP (1) JP2003501162A (en)
AU (1) AU5728000A (en)
CA (1) CA2376285C (en)
TW (1) TW458791B (en)
WO (1) WO2000074765A1 (en)

Cited By (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9687641B2 (en) 2010-05-04 2017-06-27 Corium International, Inc. Method and device for transdermal delivery of parathyroid hormone using a microprojection array
US9962534B2 (en) 2013-03-15 2018-05-08 Corium International, Inc. Microarray for delivery of therapeutic agent, methods of use, and methods of making
US10195409B2 (en) 2013-03-15 2019-02-05 Corium International, Inc. Multiple impact microprojection applicators and methods of use
US10238848B2 (en) 2007-04-16 2019-03-26 Corium International, Inc. Solvent-cast microprotrusion arrays containing active ingredient
US10245422B2 (en) 2013-03-12 2019-04-02 Corium International, Inc. Microprojection applicators and methods of use
US10384045B2 (en) 2013-03-15 2019-08-20 Corium, Inc. Microarray with polymer-free microstructures, methods of making, and methods of use
US10384046B2 (en) 2013-03-15 2019-08-20 Corium, Inc. Microarray for delivery of therapeutic agent and methods of use
US10624843B2 (en) 2014-09-04 2020-04-21 Corium, Inc. Microstructure array, methods of making, and methods of use
US10857093B2 (en) 2015-06-29 2020-12-08 Corium, Inc. Microarray for delivery of therapeutic agent, methods of use, and methods of making
US11052231B2 (en) 2012-12-21 2021-07-06 Corium, Inc. Microarray for delivery of therapeutic agent and methods of use

Families Citing this family (646)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20060002949A1 (en) 1996-11-14 2006-01-05 Army Govt. Of The Usa, As Rep. By Secretary Of The Office Of The Command Judge Advocate, Hq Usamrmc. Transcutaneous immunization without heterologous adjuvant
US6797276B1 (en) 1996-11-14 2004-09-28 The United States Of America As Represented By The Secretary Of The Army Use of penetration enhancers and barrier disruption agents to enhance the transcutaneous immune response
US6036924A (en) 1997-12-04 2000-03-14 Hewlett-Packard Company Cassette of lancet cartridges for sampling blood
US6391005B1 (en) 1998-03-30 2002-05-21 Agilent Technologies, Inc. Apparatus and method for penetration with shaft having a sensor for sensing penetration depth
US7048723B1 (en) * 1998-09-18 2006-05-23 The University Of Utah Research Foundation Surface micromachined microneedles
US6312612B1 (en) 1999-06-09 2001-11-06 The Procter & Gamble Company Apparatus and method for manufacturing an intracutaneous microneedle array
US6256533B1 (en) * 1999-06-09 2001-07-03 The Procter & Gamble Company Apparatus and method for using an intracutaneous microneedle array
US6379324B1 (en) 1999-06-09 2002-04-30 The Procter & Gamble Company Intracutaneous microneedle array apparatus
US6623457B1 (en) * 1999-09-22 2003-09-23 Becton, Dickinson And Company Method and apparatus for the transdermal administration of a substance
US6835184B1 (en) * 1999-09-24 2004-12-28 Becton, Dickinson And Company Method and device for abrading skin
US6331266B1 (en) * 1999-09-29 2001-12-18 Becton Dickinson And Company Process of making a molded device
US20020095134A1 (en) * 1999-10-14 2002-07-18 Pettis Ronald J. Method for altering drug pharmacokinetics based on medical delivery platform
US20020156453A1 (en) * 1999-10-14 2002-10-24 Pettis Ronald J. Method and device for reducing therapeutic dosage
US8465468B1 (en) 2000-06-29 2013-06-18 Becton, Dickinson And Company Intradermal delivery of substances
US7897140B2 (en) 1999-12-23 2011-03-01 Health Research, Inc. Multi DTPA conjugated tetrapyrollic compounds for phototherapeutic contrast agents
US7013179B2 (en) 2000-01-07 2006-03-14 Biowave Corporation Percutaneous electrode array
US20080033492A1 (en) * 2000-01-07 2008-02-07 Biowave Corporation Electro-therapy method
US6558361B1 (en) * 2000-03-09 2003-05-06 Nanopass Ltd. Systems and methods for the transport of fluids through a biological barrier and production techniques for such systems
US6629949B1 (en) 2000-05-08 2003-10-07 Sterling Medivations, Inc. Micro infusion drug delivery device
US6659982B2 (en) 2000-05-08 2003-12-09 Sterling Medivations, Inc. Micro infusion drug delivery device
US6595947B1 (en) 2000-05-22 2003-07-22 Becton, Dickinson And Company Topical delivery of vaccines
US6565532B1 (en) 2000-07-12 2003-05-20 The Procter & Gamble Company Microneedle apparatus used for marking skin and for dispensing semi-permanent subcutaneous makeup
AU2001275138A1 (en) * 2000-06-02 2001-12-17 The University Of Utah Research Foundation Active needle devices with integrated functionality
US6540675B2 (en) 2000-06-27 2003-04-01 Rosedale Medical, Inc. Analyte monitor
US20040175360A1 (en) * 2000-06-29 2004-09-09 Pettis Ronald J. Method for altering drug pharmacokinetics based on medical delivery platform
US6603987B2 (en) * 2000-07-11 2003-08-05 Bayer Corporation Hollow microneedle patch
WO2002015960A2 (en) * 2000-08-21 2002-02-28 The Cleveland Clinic Foundation Microneedle array module and method of fabricating the same
US6533949B1 (en) * 2000-08-28 2003-03-18 Nanopass Ltd. Microneedle structure and production method therefor
US7131987B2 (en) * 2000-10-16 2006-11-07 Corium International, Inc. Microstructures and method for treating and conditioning skin which cause less irritation during exfoliation
US7828827B2 (en) 2002-05-24 2010-11-09 Corium International, Inc. Method of exfoliation of skin using closely-packed microstructures
US7108681B2 (en) 2000-10-16 2006-09-19 Corium International, Inc. Microstructures for delivering a composition cutaneously to skin
WO2002045771A2 (en) * 2000-11-09 2002-06-13 Biovalve Technologies, Inc. Microneedle adapter
US8641644B2 (en) 2000-11-21 2014-02-04 Sanofi-Aventis Deutschland Gmbh Blood testing apparatus having a rotatable cartridge with multiple lancing elements and testing means
US6591133B1 (en) 2000-11-27 2003-07-08 Microlin Llc Apparatus and methods for fluid delivery using electroactive needles and implantable electrochemical delivery devices
US7144495B2 (en) 2000-12-13 2006-12-05 Lifescan, Inc. Electrochemical test strip with an integrated micro-needle and associated methods
US6663820B2 (en) 2001-03-14 2003-12-16 The Procter & Gamble Company Method of manufacturing microneedle structures using soft lithography and photolithography
BR0116972A (en) * 2001-04-13 2004-12-21 Becton Dickinson Co Methods and devices for administering substances to the intradermal skin layer for systemic absorption
DE60233939D1 (en) * 2001-04-20 2009-11-19 Alza Corp MICROPROJECTION ARRANGEMENT WITH A COATING CONTAINING ADVANTAGEOUS MEDIUM
US6591124B2 (en) * 2001-05-11 2003-07-08 The Procter & Gamble Company Portable interstitial fluid monitoring system
DE60213976T2 (en) * 2001-06-08 2007-04-26 Becton Dickinson And Co. DEVICE FOR MANIPULATING NEEDLES OR POLISHING ARRAY
US20020188310A1 (en) * 2001-06-08 2002-12-12 Seward Kirk Partick Microfabricated surgical device
US6501976B1 (en) 2001-06-12 2002-12-31 Lifescan, Inc. Percutaneous biological fluid sampling and analyte measurement devices and methods
US6837988B2 (en) * 2001-06-12 2005-01-04 Lifescan, Inc. Biological fluid sampling and analyte measurement devices and methods
US6793632B2 (en) * 2001-06-12 2004-09-21 Lifescan, Inc. Percutaneous biological fluid constituent sampling and measurement devices and methods
ES2352998T3 (en) 2001-06-12 2011-02-24 Pelikan Technologies Inc. LANCETA ELECTRIC ACTUATOR.
US9226699B2 (en) 2002-04-19 2016-01-05 Sanofi-Aventis Deutschland Gmbh Body fluid sampling module with a continuous compression tissue interface surface
US7981056B2 (en) 2002-04-19 2011-07-19 Pelikan Technologies, Inc. Methods and apparatus for lancet actuation
US9427532B2 (en) 2001-06-12 2016-08-30 Sanofi-Aventis Deutschland Gmbh Tissue penetration device
CA2448902C (en) 2001-06-12 2010-09-07 Pelikan Technologies, Inc. Self optimizing lancing device with adaptation means to temporal variations in cutaneous properties
WO2002100254A2 (en) 2001-06-12 2002-12-19 Pelikan Technologies, Inc. Method and apparatus for lancet launching device integrated onto a blood-sampling cartridge
US7025774B2 (en) 2001-06-12 2006-04-11 Pelikan Technologies, Inc. Tissue penetration device
US9795747B2 (en) * 2010-06-02 2017-10-24 Sanofi-Aventis Deutschland Gmbh Methods and apparatus for lancet actuation
CA2448905C (en) 2001-06-12 2010-09-07 Pelikan Technologies, Inc. Blood sampling apparatus and method
US6721586B2 (en) 2001-06-12 2004-04-13 Lifescan, Inc. Percutaneous biological fluid sampling and analyte measurement devices and methods
US6875613B2 (en) * 2001-06-12 2005-04-05 Lifescan, Inc. Biological fluid constituent sampling and measurement devices and methods
AU2002344825A1 (en) 2001-06-12 2002-12-23 Pelikan Technologies, Inc. Method and apparatus for improving success rate of blood yield from a fingerstick
US8337419B2 (en) 2002-04-19 2012-12-25 Sanofi-Aventis Deutschland Gmbh Tissue penetration device
US6576416B2 (en) 2001-06-19 2003-06-10 Lifescan, Inc. Analyte measurement device and method of use
US6749792B2 (en) 2001-07-09 2004-06-15 Lifescan, Inc. Micro-needles and methods of manufacture and use thereof
WO2003006221A1 (en) * 2001-07-10 2003-01-23 Aclara Biosciences, Inc. Injection molding a flash free microfluidic structure
SE0102736D0 (en) * 2001-08-14 2001-08-14 Patrick Griss Side opened out-of-plane microneedles for microfluidic transdermal interfacing and fabrication process of side opened out-of-plane microneedles
US20040087992A1 (en) * 2002-08-09 2004-05-06 Vladimir Gartstein Microstructures for delivering a composition cutaneously to skin using rotatable structures
WO2003024507A2 (en) * 2001-09-19 2003-03-27 Biovalve Technologies, Inc. Microneedles, microneedle arrays, and systems and methods relating to same
AU2002337788A1 (en) * 2001-09-28 2003-04-07 Biovalve Technologies, Inc. Microneedle with membrane
CA2500452A1 (en) * 2001-09-28 2003-04-03 Biovalve Technologies, Inc. Switchable microneedle arrays and systems and methods relating to same
US6689100B2 (en) * 2001-10-05 2004-02-10 Becton, Dickinson And Company Microdevice and method of delivering or withdrawing a substance through the skin of an animal
US20050065118A1 (en) * 2001-10-16 2005-03-24 Jing Wang Organosulfur inhibitors of tyrosine phosphatases
US7429258B2 (en) * 2001-10-26 2008-09-30 Massachusetts Institute Of Technology Microneedle transport device
US20040120964A1 (en) * 2001-10-29 2004-06-24 Mikszta John A. Needleless vaccination using chimeric yellow fever vaccine-vectored vaccines against heterologous flaviviruses
US20030093040A1 (en) * 2001-10-29 2003-05-15 Mikszta John A. Method and device for the delivery of a substance
JP2005526489A (en) * 2001-11-15 2005-09-08 ベクトン・ディキンソン・アンド・カンパニー Method and apparatus for integrated discovery of cell culture environment
AU2002220061A1 (en) * 2001-11-29 2003-06-17 Microlin Llc Apparatus and methods for fluid delivery using electroactive needles and implantable electrochemical delivery devices
US6952604B2 (en) * 2001-12-21 2005-10-04 Becton, Dickinson And Company Minimally-invasive system and method for monitoring analyte levels
US6908453B2 (en) * 2002-01-15 2005-06-21 3M Innovative Properties Company Microneedle devices and methods of manufacture
ES2329781T3 (en) * 2002-02-04 2009-12-01 Becton, Dickinson And Company DEVICE AND METHOD TO SUPPLY OR REMOVE A SUBSTANCE THROUGH THE SKIN.
US7004928B2 (en) 2002-02-08 2006-02-28 Rosedale Medical, Inc. Autonomous, ambulatory analyte monitor or drug delivery device
JP3933058B2 (en) * 2002-02-25 2007-06-20 日立化成工業株式会社 Support unit for microfluidic system and method for manufacturing the same
US7105103B2 (en) * 2002-03-11 2006-09-12 Becton, Dickinson And Company System and method for the manufacture of surgical blades
US7387742B2 (en) * 2002-03-11 2008-06-17 Becton, Dickinson And Company Silicon blades for surgical and non-surgical use
US7115108B2 (en) * 2002-04-02 2006-10-03 Becton, Dickinson And Company Method and device for intradermally delivering a substance
US6780171B2 (en) 2002-04-02 2004-08-24 Becton, Dickinson And Company Intradermal delivery device
US7047070B2 (en) * 2002-04-02 2006-05-16 Becton, Dickinson And Company Valved intradermal delivery device and method of intradermally delivering a substance to a patient
US8579831B2 (en) 2002-04-19 2013-11-12 Sanofi-Aventis Deutschland Gmbh Method and apparatus for penetrating tissue
US9314194B2 (en) 2002-04-19 2016-04-19 Sanofi-Aventis Deutschland Gmbh Tissue penetration device
US8360992B2 (en) 2002-04-19 2013-01-29 Sanofi-Aventis Deutschland Gmbh Method and apparatus for penetrating tissue
US7547287B2 (en) 2002-04-19 2009-06-16 Pelikan Technologies, Inc. Method and apparatus for penetrating tissue
US8267870B2 (en) 2002-04-19 2012-09-18 Sanofi-Aventis Deutschland Gmbh Method and apparatus for body fluid sampling with hybrid actuation
US7175642B2 (en) 2002-04-19 2007-02-13 Pelikan Technologies, Inc. Methods and apparatus for lancet actuation
US7674232B2 (en) 2002-04-19 2010-03-09 Pelikan Technologies, Inc. Method and apparatus for penetrating tissue
US8221334B2 (en) 2002-04-19 2012-07-17 Sanofi-Aventis Deutschland Gmbh Method and apparatus for penetrating tissue
US7909778B2 (en) 2002-04-19 2011-03-22 Pelikan Technologies, Inc. Method and apparatus for penetrating tissue
US7901362B2 (en) 2002-04-19 2011-03-08 Pelikan Technologies, Inc. Method and apparatus for penetrating tissue
US7713214B2 (en) 2002-04-19 2010-05-11 Pelikan Technologies, Inc. Method and apparatus for a multi-use body fluid sampling device with optical analyte sensing
US7229458B2 (en) 2002-04-19 2007-06-12 Pelikan Technologies, Inc. Method and apparatus for penetrating tissue
US7331931B2 (en) 2002-04-19 2008-02-19 Pelikan Technologies, Inc. Method and apparatus for penetrating tissue
US8702624B2 (en) 2006-09-29 2014-04-22 Sanofi-Aventis Deutschland Gmbh Analyte measurement device with a single shot actuator
US7892183B2 (en) 2002-04-19 2011-02-22 Pelikan Technologies, Inc. Method and apparatus for body fluid sampling and analyte sensing
US7491178B2 (en) * 2002-04-19 2009-02-17 Pelikan Technologies, Inc. Method and apparatus for penetrating tissue
US8784335B2 (en) 2002-04-19 2014-07-22 Sanofi-Aventis Deutschland Gmbh Body fluid sampling device with a capacitive sensor
US7976476B2 (en) 2002-04-19 2011-07-12 Pelikan Technologies, Inc. Device and method for variable speed lancet
US9248267B2 (en) 2002-04-19 2016-02-02 Sanofi-Aventis Deustchland Gmbh Tissue penetration device
US7232451B2 (en) 2002-04-19 2007-06-19 Pelikan Technologies, Inc. Method and apparatus for penetrating tissue
US7371247B2 (en) 2002-04-19 2008-05-13 Pelikan Technologies, Inc Method and apparatus for penetrating tissue
US9795334B2 (en) 2002-04-19 2017-10-24 Sanofi-Aventis Deutschland Gmbh Method and apparatus for penetrating tissue
US8372016B2 (en) 2002-04-19 2013-02-12 Sanofi-Aventis Deutschland Gmbh Method and apparatus for body fluid sampling and analyte sensing
US7717863B2 (en) 2002-04-19 2010-05-18 Pelikan Technologies, Inc. Method and apparatus for penetrating tissue
US7291117B2 (en) 2002-04-19 2007-11-06 Pelikan Technologies, Inc. Method and apparatus for penetrating tissue
US7648468B2 (en) 2002-04-19 2010-01-19 Pelikon Technologies, Inc. Method and apparatus for penetrating tissue
US7297122B2 (en) 2002-04-19 2007-11-20 Pelikan Technologies, Inc. Method and apparatus for penetrating tissue
US7060192B2 (en) 2002-05-09 2006-06-13 Lifescan, Inc. Methods of fabricating physiological sample collection devices
US6945952B2 (en) * 2002-06-25 2005-09-20 Theraject, Inc. Solid solution perforator for drug delivery and other applications
EP1517684B1 (en) 2002-06-27 2009-07-22 Health Research, Inc. Fluorinated chlorin and bacteriochlorin photosensitizers for photodynamic therapy
US6899838B2 (en) * 2002-07-12 2005-05-31 Becton, Dickinson And Company Method of forming a mold and molding a micro-device
KR20120087197A (en) 2002-07-19 2012-08-06 쓰리엠 이노베이티브 프로퍼티즈 컴파니 Microneedle device, method of using microneedle device and method of delivering microneedle device
ES2617576T3 (en) * 2002-08-29 2017-06-19 Becton, Dickinson And Company Substance administration through a rotating microabrasive system
AU2003275311A1 (en) * 2002-09-16 2004-04-30 Sung-Yun Kwon Solid micro-perforators and methods of use
US20040106904A1 (en) * 2002-10-07 2004-06-03 Gonnelli Robert R. Microneedle array patch
CA2444211C (en) * 2002-10-11 2013-11-19 Dermal Therapy (Barbados) Inc. Determination of biological conditions using impedance measurements
US7381184B2 (en) 2002-11-05 2008-06-03 Abbott Diabetes Care Inc. Sensor inserter assembly
US7611482B2 (en) * 2002-11-21 2009-11-03 Boston Scientific Scimed, Inc. Minimally-invasive smart devices
US8574895B2 (en) 2002-12-30 2013-11-05 Sanofi-Aventis Deutschland Gmbh Method and apparatus using optical techniques to measure analyte levels
US7578954B2 (en) * 2003-02-24 2009-08-25 Corium International, Inc. Method for manufacturing microstructures having multiple microelements with through-holes
US20090007436A1 (en) * 2003-03-10 2009-01-08 Daskal Vadim M Silicon blades for surgical and non-surgical use
US20050155955A1 (en) * 2003-03-10 2005-07-21 Daskal Vadim M. Method for reducing glare and creating matte finish of controlled density on a silicon surface
US7052652B2 (en) 2003-03-24 2006-05-30 Rosedale Medical, Inc. Analyte concentration detection devices and methods
US20050070819A1 (en) * 2003-03-31 2005-03-31 Rosedale Medical, Inc. Body fluid sampling constructions and techniques
US7415299B2 (en) * 2003-04-18 2008-08-19 The Regents Of The University Of California Monitoring method and/or apparatus
JP2004343275A (en) * 2003-05-14 2004-12-02 Murata Mach Ltd Image processing system and scanner
BRPI0410348A (en) * 2003-05-14 2006-05-30 Torreypines Therapeutics Inc compounds and uses thereof in amyloid-beta modulation
CN1321706C (en) * 2003-05-29 2007-06-20 财团法人工业技术研究院 Numerical group style micro-needle soft substrate structure and its manufacture
EP2238892A3 (en) 2003-05-30 2011-02-09 Pelikan Technologies Inc. Apparatus for body fluid sampling
US7572405B2 (en) * 2003-06-02 2009-08-11 Corium International Inc. Method for manufacturing microstructures having hollow microelements using fluidic jets during a molding operation
US7850621B2 (en) 2003-06-06 2010-12-14 Pelikan Technologies, Inc. Method and apparatus for body fluid sampling and analyte sensing
WO2006001797A1 (en) 2004-06-14 2006-01-05 Pelikan Technologies, Inc. Low pain penetrating
US20050123507A1 (en) * 2003-06-30 2005-06-09 Mahmoud Ameri Formulations for coated microprojections having controlled solubility
MXPA06000281A (en) * 2003-06-30 2006-07-03 Johnson & Johnson Formulations for coated microprojections containing non-volatile counterions.
WO2005009645A2 (en) * 2003-07-21 2005-02-03 10X Technology Llc. Apparatus and method for manufacturing microneedles
MXPA06001414A (en) * 2003-08-04 2006-08-25 Johnson & Johnson Method and device for enhancing transdermal agent flux.
WO2005020912A2 (en) * 2003-08-25 2005-03-10 3M Innovative Properties Company Delivery of immune response modifier compounds
JP4603547B2 (en) 2003-09-11 2010-12-22 セラノス， インコーポレイテッド Medical devices for analyte monitoring and drug delivery
US7785485B2 (en) * 2003-09-17 2010-08-31 Becton, Dickinson And Company System and method for creating linear and non-linear trenches in silicon and other crystalline materials with a router
WO2005033659A2 (en) 2003-09-29 2005-04-14 Pelikan Technologies, Inc. Method and apparatus for an improved sample capture device
WO2005037095A1 (en) 2003-10-14 2005-04-28 Pelikan Technologies, Inc. Method and apparatus for a variable user interface
US7744738B1 (en) 2003-10-16 2010-06-29 The University Of Notre Dame Method and apparatus for rapid particle manipulation and characterization
US8267914B1 (en) * 2003-10-16 2012-09-18 University Of Notre Dame Du Lac Method and apparatus for AC electrospray
WO2005042054A2 (en) * 2003-10-24 2005-05-12 Alza Corporation Pretreatment method and system for enhancing transdermal drug delivery
USD914881S1 (en) 2003-11-05 2021-03-30 Abbott Diabetes Care Inc. Analyte sensor electronic mount
KR20070011240A (en) * 2003-11-13 2007-01-24 알자 코포레이션 System and method for transdermal delivery
JP2007512052A (en) * 2003-11-28 2007-05-17 アクルックス・ディ・ディ・エス・プロプライエタリー・リミテッド Rapid transdermal delivery systems and methods
US8017145B2 (en) * 2003-12-22 2011-09-13 Conopco, Inc. Exfoliating personal care wipe article containing an array of projections
CA2552385C (en) * 2003-12-29 2013-07-23 3M Innovative Properties Company Medical devices and kits including same
US7822454B1 (en) 2005-01-03 2010-10-26 Pelikan Technologies, Inc. Fluid sampling device with improved analyte detecting member configuration
US8668656B2 (en) 2003-12-31 2014-03-11 Sanofi-Aventis Deutschland Gmbh Method and apparatus for improving fluidic flow and sample capture
CN1636505B (en) * 2004-01-09 2011-11-09 希森美康株式会社 Extracting implement, extracting apparatus, and apparatus for measuring blood sugar rate
US7351246B2 (en) * 2004-01-20 2008-04-01 Epley John M Minimally invasive, sustained, intra-tympanic drug delivery system
GB0402131D0 (en) 2004-01-30 2004-03-03 Isis Innovation Delivery method
WO2005090370A1 (en) * 2004-02-05 2005-09-29 The Regents Of The University Of California Pharmacologically active agents containing esterified phosphonates and methods for use thereof
DE602005017602D1 (en) * 2004-02-18 2009-12-24 Hitachi Chemical Co Ltd Microfluidic unit with hollow fiber channel
JP2007523771A (en) * 2004-02-23 2007-08-23 スリーエム イノベイティブ プロパティズ カンパニー Microneedle array molding method
WO2005091922A2 (en) * 2004-03-03 2005-10-06 Becton, Dickinson And Company Methods and devices for improving delivery of a substance to skin
US20050203575A1 (en) * 2004-03-15 2005-09-15 Unilever Home & Personal Care Usa, Division Of Conopco, Inc. Skin microactivation system and method
CA2560840C (en) 2004-03-24 2014-05-06 Corium International, Inc. Transdermal delivery device
AU2005231443B2 (en) 2004-04-01 2012-02-23 The General Hospital Corporation Method and apparatus for dermatological treatment and tissue reshaping
US20080082090A1 (en) * 2004-04-01 2008-04-03 The General Hospital Corporation Method and apparatus for dermatological treatment and tissue reshaping
US7396484B2 (en) * 2004-04-30 2008-07-08 Becton, Dickinson And Company Methods of fabricating complex blade geometries from silicon wafers and strengthening blade geometries
WO2005112984A2 (en) 2004-05-13 2005-12-01 Alza Corporation Apparatus and method for transdermal delivery of parathyroid hormone agents
EP1755585A4 (en) 2004-05-20 2009-04-01 Scripps Research Inst Transthyretin stabilization
EP1751546A2 (en) 2004-05-20 2007-02-14 Albatros Technologies GmbH & Co. KG Printable hydrogel for biosensors
US9775553B2 (en) 2004-06-03 2017-10-03 Sanofi-Aventis Deutschland Gmbh Method and apparatus for a fluid sampling device
WO2005120365A1 (en) 2004-06-03 2005-12-22 Pelikan Technologies, Inc. Method and apparatus for a fluid sampling device
WO2005123173A1 (en) * 2004-06-10 2005-12-29 3M Innovative Properties Company Patch application device and kit
WO2006009876A2 (en) * 2004-06-17 2006-01-26 Cengent Therapeutics, Inc. Trisubstituted nitrogen modulators of tyrosine phosphatases
JP2008505916A (en) * 2004-07-09 2008-02-28 メタバシス・セラピューティクス・インコーポレイテッド Oxygen / nitrogen heterocycle inhibitors of tyrosine phosphatase
TWI246929B (en) * 2004-07-16 2006-01-11 Ind Tech Res Inst Microneedle array device and its fabrication method
US7150904B2 (en) * 2004-07-27 2006-12-19 Ut-Battelle, Llc Composite, ordered material having sharp surface features
US20060030811A1 (en) * 2004-08-03 2006-02-09 Wong Patrick S Method and device for enhancing transdermal agent flux
US20060100584A1 (en) * 2004-08-10 2006-05-11 Orest Olejnik Needleless microprotrusion elastoplast system
WO2006028970A1 (en) * 2004-09-02 2006-03-16 Cengent Therapeutics, Inc. Derivatives of thiazole and thiadiazole inhibitors of tyrosine phosphatases
NZ584773A (en) 2004-09-17 2012-07-27 Whitehead Biomedical Inst Compounds, Compositions and Methods of Inhibiting Alpha-Synuclein Toxicity
ITPD20040252A1 (en) * 2004-10-14 2005-01-14 Bidoia Sas Di Gianfranco Bidoi SURGICAL IRRIGATOR
US8057842B2 (en) 2004-11-18 2011-11-15 3M Innovative Properties Company Method of contact coating a microneedle array
KR20070102669A (en) 2004-11-18 2007-10-19 쓰리엠 이노베이티브 프로퍼티즈 컴파니 Low-profile microneedle array applicator
WO2006055799A1 (en) * 2004-11-18 2006-05-26 3M Innovative Properties Company Masking method for coating a microneedle array
JP5015787B2 (en) 2004-11-18 2012-08-29 スリーエム イノベイティブ プロパティズ カンパニー Contact coating method of microneedle array
ATE504328T1 (en) 2004-11-18 2011-04-15 3M Innovative Properties Co MICRONEEDLE ARRANGEMENT APPLICATOR AND HOLDER
US8007466B2 (en) * 2004-11-18 2011-08-30 Nanopass Technologies Ltd. System and method for delivering fluid into flexible biological barrier
JP4728631B2 (en) * 2004-11-30 2011-07-20 Ｔｔｉ・エルビュー株式会社 Iontophoresis device
AU2005314151B2 (en) 2004-12-07 2011-09-08 3M Innovative Properties Company Method of molding a microneedle
CN100367906C (en) * 2004-12-08 2008-02-13 圣美迪诺医疗科技(湖州)有限公司 Endermic implantating biological sensors
US7590444B2 (en) * 2004-12-09 2009-09-15 Tti Ellebeau, Inc. Iontophoresis device
CN101664662A (en) * 2004-12-09 2010-03-10 日立化成工业株式会社 Support unit for micro fluid system and process for producing the same
US9398882B2 (en) 2005-09-30 2016-07-26 Abbott Diabetes Care Inc. Method and apparatus for providing analyte sensor and data processing device
US7731657B2 (en) 2005-08-30 2010-06-08 Abbott Diabetes Care Inc. Analyte sensor introducer and methods of use
US8545403B2 (en) 2005-12-28 2013-10-01 Abbott Diabetes Care Inc. Medical device insertion
US9788771B2 (en) 2006-10-23 2017-10-17 Abbott Diabetes Care Inc. Variable speed sensor insertion devices and methods of use
US8512243B2 (en) 2005-09-30 2013-08-20 Abbott Diabetes Care Inc. Integrated introducer and transmitter assembly and methods of use
US9351669B2 (en) 2009-09-30 2016-05-31 Abbott Diabetes Care Inc. Interconnect for on-body analyte monitoring device
US20090105569A1 (en) 2006-04-28 2009-04-23 Abbott Diabetes Care, Inc. Introducer Assembly and Methods of Use
US8333714B2 (en) 2006-09-10 2012-12-18 Abbott Diabetes Care Inc. Method and system for providing an integrated analyte sensor insertion device and data processing unit
US8571624B2 (en) 2004-12-29 2013-10-29 Abbott Diabetes Care Inc. Method and apparatus for mounting a data transmission device in a communication system
US10226207B2 (en) 2004-12-29 2019-03-12 Abbott Diabetes Care Inc. Sensor inserter having introducer
US9572534B2 (en) 2010-06-29 2017-02-21 Abbott Diabetes Care Inc. Devices, systems and methods for on-skin or on-body mounting of medical devices
US7697967B2 (en) 2005-12-28 2010-04-13 Abbott Diabetes Care Inc. Method and apparatus for providing analyte sensor insertion
US7883464B2 (en) * 2005-09-30 2011-02-08 Abbott Diabetes Care Inc. Integrated transmitter unit and sensor introducer mechanism and methods of use
US9259175B2 (en) 2006-10-23 2016-02-16 Abbott Diabetes Care, Inc. Flexible patch for fluid delivery and monitoring body analytes
US8029441B2 (en) 2006-02-28 2011-10-04 Abbott Diabetes Care Inc. Analyte sensor transmitter unit configuration for a data monitoring and management system
US9743862B2 (en) 2011-03-31 2017-08-29 Abbott Diabetes Care Inc. Systems and methods for transcutaneously implanting medical devices
US8652831B2 (en) 2004-12-30 2014-02-18 Sanofi-Aventis Deutschland Gmbh Method and apparatus for analyte measurement test time
JP4731931B2 (en) * 2005-02-03 2011-07-27 Ｔｔｉ・エルビュー株式会社 Iontophoresis device
JP4793806B2 (en) * 2005-03-22 2011-10-12 Ｔｔｉ・エルビュー株式会社 Iontophoresis device
WO2006105146A2 (en) * 2005-03-29 2006-10-05 Arkal Medical, Inc. Devices, systems, methods and tools for continuous glucose monitoring
WO2006130217A2 (en) * 2005-04-01 2006-12-07 The Regents Of The University Of California Substituted phosphate esters of nucleoside phosphonates
ATE534652T1 (en) 2005-04-01 2011-12-15 Univ California PHOSPHONO-PENT-2-EN-1-YL NUCLEOSIDES AND ANALOGS
JP5301985B2 (en) 2005-04-07 2013-09-25 スリーエム イノベイティブ プロパティズ カンパニー System and method for tool feedback sensing
NZ564141A (en) 2005-05-09 2011-02-25 Theranos Inc Two way communication system for monitoring an analyte
US7850683B2 (en) * 2005-05-20 2010-12-14 Myoscience, Inc. Subdermal cryogenic remodeling of muscles, nerves, connective tissue, and/or adipose tissue (fat)
US7713266B2 (en) 2005-05-20 2010-05-11 Myoscience, Inc. Subdermal cryogenic remodeling of muscles, nerves, connective tissue, and/or adipose tissue (fat)
US20080269666A1 (en) * 2005-05-25 2008-10-30 Georgia Tech Research Corporation Microneedles and Methods for Microinfusion
US20060281187A1 (en) 2005-06-13 2006-12-14 Rosedale Medical, Inc. Analyte detection devices and methods with hematocrit/volume correction and feedback control
EP1893130A4 (en) 2005-06-17 2015-08-26 Georgia Tech Res Inst Coated microstructures and method of manufacture thereof
WO2007002109A2 (en) * 2005-06-20 2007-01-04 The Regents Of The University Of California Multidentate pyrone-derived chelators for medicinal imaging and chelation
EP1904158B1 (en) 2005-06-24 2013-07-24 3M Innovative Properties Company Collapsible patch with microneedle array
AU2006261899B2 (en) 2005-06-27 2012-05-10 Kindeva Drug Delivery L.P. Microneedle cartridge assembly and method of applying
CA2613111C (en) * 2005-06-27 2015-05-26 3M Innovative Properties Company Microneedle array applicator device and method of array application
US20070025869A1 (en) * 2005-07-15 2007-02-01 Gordon John H Fluid Delivery Device
US20070078414A1 (en) * 2005-08-05 2007-04-05 Mcallister Devin V Methods and devices for delivering agents across biological barriers
US20070088332A1 (en) * 2005-08-22 2007-04-19 Transcutaneous Technologies Inc. Iontophoresis device
DE102005040251A1 (en) * 2005-08-24 2007-03-01 Boehringer Ingelheim Pharma Gmbh & Co. Kg Transcorneal drug delivery system
US20080058282A1 (en) 2005-08-30 2008-03-06 Fallon Joan M Use of lactulose in the treatment of autism
JP4519037B2 (en) * 2005-08-31 2010-08-04 東京エレクトロン株式会社 Heating device and coating / developing device
US20090035446A1 (en) * 2005-09-06 2009-02-05 Theraject, Inc. Solid Solution Perforator Containing Drug Particle and/or Drug-Adsorbed Particles
US8518069B2 (en) 2005-09-07 2013-08-27 Cabochon Aesthetics, Inc. Dissection handpiece and method for reducing the appearance of cellulite
US10548659B2 (en) 2006-01-17 2020-02-04 Ulthera, Inc. High pressure pre-burst for improved fluid delivery
US7967763B2 (en) * 2005-09-07 2011-06-28 Cabochon Aesthetics, Inc. Method for treating subcutaneous tissues
US9486274B2 (en) 2005-09-07 2016-11-08 Ulthera, Inc. Dissection handpiece and method for reducing the appearance of cellulite
US9358033B2 (en) 2005-09-07 2016-06-07 Ulthera, Inc. Fluid-jet dissection system and method for reducing the appearance of cellulite
JP2009506873A (en) * 2005-09-07 2009-02-19 ザ ファウンドリー， インコーポレイテッド Apparatus and method for disrupting subcutaneous structures
US9011473B2 (en) 2005-09-07 2015-04-21 Ulthera, Inc. Dissection handpiece and method for reducing the appearance of cellulite
BRPI0616165A2 (en) 2005-09-15 2011-06-07 Tti Ellebeau Inc rod type iontophoresis device
US20070066934A1 (en) * 2005-09-19 2007-03-22 Transport Pharmaceuticals, Inc. Electrokinetic delivery system and methods therefor
US20070185432A1 (en) * 2005-09-19 2007-08-09 Transport Pharmaceuticals, Inc. Electrokinetic system and method for delivering methotrexate
US8492428B2 (en) * 2005-09-20 2013-07-23 Mayo Foundation For Medical Education And Research Small-molecule botulinum toxin inhibitors
JP2009509634A (en) * 2005-09-30 2009-03-12 Ｔｔｉ・エルビュー株式会社 Functionalized microneedle transdermal drug delivery system, apparatus and method
US8801631B2 (en) 2005-09-30 2014-08-12 Intuity Medical, Inc. Devices and methods for facilitating fluid transport
WO2007041526A2 (en) * 2005-09-30 2007-04-12 Transcutaneous Technologies Inc. Iontophoresis apparatus and method to deliver antibiotics to biological interfaces
US9521968B2 (en) 2005-09-30 2016-12-20 Abbott Diabetes Care Inc. Analyte sensor retention mechanism and methods of use
JP2009509677A (en) * 2005-09-30 2009-03-12 Ｔｔｉ・エルビュー株式会社 Iontophoretic delivery of vesicle encapsulated active substances
JP2009509685A (en) * 2005-09-30 2009-03-12 Ｔｔｉ・エルビュー株式会社 Iontophoresis device and method for delivery of angiogenic factors to enhance healing of damaged tissue
CA2624059C (en) 2005-09-30 2019-04-02 Intuity Medical, Inc. Multi-site body fluid sampling and analysis cartridge
US7574256B2 (en) * 2005-09-30 2009-08-11 Tti Ellebeau, Inc. Iontophoretic device and method of delivery of active agents to biological interface
US20070078375A1 (en) * 2005-09-30 2007-04-05 Transcutaneous Technologies Inc. Iontophoretic delivery of active agents conjugated to nanoparticles
WO2007061964A1 (en) * 2005-11-18 2007-05-31 3M Innovative Properties Company Methods for coating microneedles
US20080262416A1 (en) * 2005-11-18 2008-10-23 Duan Daniel C Microneedle Arrays and Methods of Preparing Same
US9248317B2 (en) 2005-12-02 2016-02-02 Ulthera, Inc. Devices and methods for selectively lysing cells
US7885793B2 (en) 2007-05-22 2011-02-08 International Business Machines Corporation Method and system for developing a conceptual model to facilitate generating a business-aligned information technology solution
US9636035B2 (en) * 2005-12-14 2017-05-02 Scibase Ab Medical apparatus for determination of biological conditions using impedance measurements
WO2007075614A1 (en) * 2005-12-21 2007-07-05 3M Innovative Properties Company Microneedle devices
US10799285B2 (en) * 2005-12-22 2020-10-13 Inmode Ltd. Skin rejuvenation resurfacing device and method of use
US7618429B2 (en) * 2005-12-22 2009-11-17 Spamedica International Srl Skin rejuvination resurfacing method
US11298058B2 (en) 2005-12-28 2022-04-12 Abbott Diabetes Care Inc. Method and apparatus for providing analyte sensor insertion
WO2007079193A2 (en) 2005-12-30 2007-07-12 Tti Ellebeau, Inc. Iontophoretic systems, devices, and methods of delivery of active agents to biological interface
US7658728B2 (en) * 2006-01-10 2010-02-09 Yuzhakov Vadim V Microneedle array, patch, and applicator for transdermal drug delivery
US9339641B2 (en) 2006-01-17 2016-05-17 Emkinetics, Inc. Method and apparatus for transdermal stimulation over the palmar and plantar surfaces
US9610459B2 (en) 2009-07-24 2017-04-04 Emkinetics, Inc. Cooling systems and methods for conductive coils
US20070202186A1 (en) 2006-02-22 2007-08-30 Iscience Interventional Corporation Apparatus and formulations for suprachoroidal drug delivery
US8741230B2 (en) 2006-03-24 2014-06-03 Theranos, Inc. Systems and methods of sample processing and fluid control in a fluidic system
US11287421B2 (en) 2006-03-24 2022-03-29 Labrador Diagnostics Llc Systems and methods of sample processing and fluid control in a fluidic system
US20100049021A1 (en) * 2006-03-28 2010-02-25 Jina Arvind N Devices, systems, methods and tools for continuous analyte monitoring
US20090131778A1 (en) * 2006-03-28 2009-05-21 Jina Arvind N Devices, systems, methods and tools for continuous glucose monitoring
US20080154107A1 (en) * 2006-12-20 2008-06-26 Jina Arvind N Device, systems, methods and tools for continuous glucose monitoring
EP2007373A4 (en) * 2006-03-29 2012-12-19 Foldrx Pharmaceuticals Inc Inhibition of alpha-synuclein toxicity
US9119945B2 (en) * 2006-04-20 2015-09-01 3M Innovative Properties Company Device for applying a microneedle array
WO2007131050A2 (en) * 2006-05-02 2007-11-15 Georgia Tech Research Corporation Method for drug delivery to ocular tissue using microneedle
US8197435B2 (en) 2006-05-02 2012-06-12 Emory University Methods and devices for drug delivery to ocular tissue using microneedle
US8007999B2 (en) 2006-05-10 2011-08-30 Theranos, Inc. Real-time detection of influenza virus
US20070276318A1 (en) * 2006-05-26 2007-11-29 Mit, Llp Iontosonic-microneedle applicator apparatus and methods
US20070276211A1 (en) * 2006-05-26 2007-11-29 Jose Mir Compact minimally invasive biomedical monitor
US20070282246A1 (en) * 2006-06-05 2007-12-06 Mit, Llp Iontosonic-microneedle biosensor apparatus and methods
US20070292492A1 (en) * 2006-06-16 2007-12-20 Friden Phllip M Pharmaceutical formulations for iontophoretic tetracycline antibiotic delivery
US20080008745A1 (en) * 2006-06-21 2008-01-10 University Of Kentucky Research Foundation Transdermal delivery of naltrexone hydrochloride, naltrexol hydrochloride, and bis(hydroxy-methyl)propionyl-3-0 ester naltrexone using microneedles
JP5338021B2 (en) * 2006-07-04 2013-11-13 凸版印刷株式会社 Manufacturing method of needle-shaped body
JP4265696B2 (en) 2006-07-04 2009-05-20 凸版印刷株式会社 Manufacturing method of microneedle
JP5241714B2 (en) 2006-07-07 2013-07-17 プロテウス デジタル ヘルス， インコーポレイテッド Smart parenteral delivery system
US20100100005A1 (en) * 2006-07-11 2010-04-22 Infotonics Technology Center, Inc. Minimally invasive allergy testing system with coated allergens
KR100781702B1 (en) * 2006-07-21 2007-12-03 연세대학교 산학협력단 A hollow type microneedle and methods for preparing it
KR100793615B1 (en) * 2006-07-21 2008-01-10 연세대학교 산학협력단 A biodegradable solid type microneedle and methods for preparing it
EP2062612A4 (en) * 2006-08-18 2010-01-06 Toppan Printing Co Ltd Microneedle and microneedle patch
DK2484696T3 (en) 2006-08-28 2017-10-02 Kyowa Hakko Kirin Co Ltd Antagonistic hLIGHT-specific human monoclonal antibodies
US20080058726A1 (en) * 2006-08-30 2008-03-06 Arvind Jina Methods and Apparatus Incorporating a Surface Penetration Device
US11224742B2 (en) 2006-10-02 2022-01-18 Emkinetics, Inc. Methods and devices for performing electrical stimulation to treat various conditions
US10786669B2 (en) 2006-10-02 2020-09-29 Emkinetics, Inc. Method and apparatus for transdermal stimulation over the palmar and plantar surfaces
US9005102B2 (en) 2006-10-02 2015-04-14 Emkinetics, Inc. Method and apparatus for electrical stimulation therapy
CA2665134A1 (en) 2006-10-02 2008-04-10 Emkinetics, Inc. Method and apparatus for magnetic induction therapy
HUE042044T2 (en) * 2006-10-17 2019-06-28 Inovio Pharmaceuticals Inc Electroporation devices for electroporation of cells in mammals
US20080113391A1 (en) 2006-11-14 2008-05-15 Ian Gibbons Detection and quantification of analytes in bodily fluids
EP2090331A4 (en) * 2006-11-22 2012-04-18 Toppan Printing Co Ltd Microneedle array and process for production thereof
US7785301B2 (en) * 2006-11-28 2010-08-31 Vadim V Yuzhakov Tissue conforming microneedle array and patch for transdermal drug delivery or biological fluid collection
CA2671069A1 (en) * 2006-12-01 2008-06-12 Tti Ellebeau, Inc. Systems, devices, and methods for powering and/or controlling devices, for instance transdermal delivery devices
WO2008073806A1 (en) * 2006-12-08 2008-06-19 Sabic Innovative Plastics Ip B.V. Active transdermal drug delivery system
US20080147186A1 (en) * 2006-12-14 2008-06-19 Joshi Ashok V Electrochemical Implant For Delivering Beneficial Agents
US20080152592A1 (en) * 2006-12-21 2008-06-26 Bayer Healthcare Llc Method of therapeutic drug monitoring
US9254162B2 (en) 2006-12-21 2016-02-09 Myoscience, Inc. Dermal and transdermal cryogenic microprobe systems
CA2676221C (en) 2007-01-22 2016-12-20 Corium International, Inc. Applicators for microneedles
US8409185B2 (en) * 2007-02-16 2013-04-02 Myoscience, Inc. Replaceable and/or easily removable needle systems for dermal and transdermal cryogenic remodeling
EP2125073A1 (en) * 2007-03-02 2009-12-02 TecPharma Licensing AG Modular administration system
US7713196B2 (en) 2007-03-09 2010-05-11 Nellcor Puritan Bennett Llc Method for evaluating skin hydration and fluid compartmentalization
US8560059B2 (en) * 2007-03-09 2013-10-15 Covidien Lp System and methods for optical sensing and drug delivery using microneedles
US20080234562A1 (en) * 2007-03-19 2008-09-25 Jina Arvind N Continuous analyte monitor with multi-point self-calibration
US20100210932A1 (en) * 2007-03-20 2010-08-19 Bayer Healthcare Llc Method of analyzing an analyte
US8439861B2 (en) 2007-04-24 2013-05-14 Velcro Industries B.V. Skin penetrating touch fasteners
WO2008150917A1 (en) 2007-05-31 2008-12-11 Abbott Diabetes Care, Inc. Insertion devices and methods
US20080312648A1 (en) * 2007-06-12 2008-12-18 Darion Peterson Fat removal and sculpting device
US20080312518A1 (en) * 2007-06-14 2008-12-18 Arkal Medical, Inc On-demand analyte monitor and method of use
CA2728140C (en) 2007-06-27 2019-09-03 The Board Of Trustees Of The Leland Stanford Junior University Peptide tyrosinase inhibitors and uses thereof
EP2173370B1 (en) * 2007-06-27 2015-10-21 The Board of Trustees of the Leland Stanford Junior University Oligopeptide tyrosinase inhibitors and uses thereof
US7959969B2 (en) 2007-07-10 2011-06-14 California Institute Of Technology Fabrication of anchored carbon nanotube array devices for integrated light collection and energy conversion
EP2178524A4 (en) * 2007-08-06 2013-09-04 Transderm Inc Microneedle arrays formed from polymer films
US8158430B1 (en) 2007-08-06 2012-04-17 Theranos, Inc. Systems and methods of fluidic sample processing
US8328720B2 (en) * 2007-08-10 2012-12-11 Infotonics Technology Center, Inc. MEMS interstitial prothrombin time test
US20090053673A1 (en) * 2007-08-23 2009-02-26 Zimmer, Inc. Method for localized treatment of periodontal tissue
WO2009029572A1 (en) * 2007-08-24 2009-03-05 Deka Products Limited Partnership Microneedle systems and apparatus
US20100121307A1 (en) * 2007-08-24 2010-05-13 Microfabrica Inc. Microneedles, Microneedle Arrays, Methods for Making, and Transdermal and/or Intradermal Applications
WO2009039366A1 (en) * 2007-09-20 2009-03-26 Transport Pharmaceuticals, Inc. Method of enhancing iontophoretic delivery of a peptide
US9549746B2 (en) * 2007-09-28 2017-01-24 The Queen's University Of Belfast Delivery device and method
US20090264421A1 (en) * 2007-10-05 2009-10-22 Bible Keith C Methods and Compositions for Treating Cancer
US8439940B2 (en) 2010-12-22 2013-05-14 Cabochon Aesthetics, Inc. Dissection handpiece with aspiration means for reducing the appearance of cellulite
WO2009048607A1 (en) 2007-10-10 2009-04-16 Corium International, Inc. Vaccine delivery via microneedle arrays
US20090099427A1 (en) * 2007-10-12 2009-04-16 Arkal Medical, Inc. Microneedle array with diverse needle configurations
WO2009055733A1 (en) 2007-10-25 2009-04-30 Proteus Biomedical, Inc. Fluid transfer port information system
US8298216B2 (en) 2007-11-14 2012-10-30 Myoscience, Inc. Pain management using cryogenic remodeling
WO2009067463A1 (en) 2007-11-19 2009-05-28 Proteus Biomedical, Inc. Body-associated fluid transport structure evaluation devices
SG186008A1 (en) 2007-11-21 2012-12-28 Pharmaxis Ltd Haloallylamine inhibitors of ssao/vap-1 and uses therefor
JP5461427B2 (en) * 2007-12-17 2014-04-02 ニューワールド ファーマシューティカルズ，エルエルシー Integrated intradermal delivery, diagnosis and communication system
AU2008341030B2 (en) 2007-12-24 2014-04-17 Vaxxas Pty Limited Coating method
US8986253B2 (en) 2008-01-25 2015-03-24 Tandem Diabetes Care, Inc. Two chamber pumps and related methods
AU2009212106B9 (en) 2008-02-07 2014-05-22 Vaxxas Pty Limited Patch production
GB0802447D0 (en) * 2008-02-09 2008-03-19 Univ Manchester Fluid extraction device, associated materials and methods
US8658163B2 (en) 2008-03-13 2014-02-25 Curemark Llc Compositions and use thereof for treating symptoms of preeclampsia
US8591481B2 (en) 2008-03-21 2013-11-26 Ut-Battelle, Llc Microfabricated instruments and methods to treat recurrent corneal erosion
CN100579599C (en) * 2008-04-09 2010-01-13 南京大学 Preparation of micro-needle array injection syringe
US9386944B2 (en) 2008-04-11 2016-07-12 Sanofi-Aventis Deutschland Gmbh Method and apparatus for analyte detecting device
US8084025B2 (en) 2008-04-18 2011-12-27 Curemark Llc Method for the treatment of the symptoms of drug and alcohol addiction
JP5584202B2 (en) * 2008-05-21 2014-09-03 セラジェクト， インコーポレイテッド Method for manufacturing solid solution punch patch and use thereof
AU2009250341A1 (en) * 2008-05-23 2009-11-26 The University Of Queensland Analyte detection using a needle projection patch
WO2009145920A1 (en) 2008-05-30 2009-12-03 Intuity Medical, Inc. Body fluid sampling device -- sampling site interface
US10383556B2 (en) 2008-06-06 2019-08-20 Intuity Medical, Inc. Medical diagnostic devices and methods
CA2726067C (en) 2008-06-06 2020-10-20 Intuity Medical, Inc. Detection meter and mode of operation
CN105902482A (en) * 2008-06-25 2016-08-31 Fe3医学有限公司 Patches and methods for the transdermal delivery of a therapeutically effective amount of iron
ES2732453T3 (en) 2008-07-01 2019-11-22 Curemark Llc Methods and compositions for the treatment of symptoms of neurological and mental health disorders
KR101013581B1 (en) 2008-08-06 2011-02-14 라종주 Electric Skin Treatment Device
US8408421B2 (en) 2008-09-16 2013-04-02 Tandem Diabetes Care, Inc. Flow regulating stopcocks and related methods
US8650937B2 (en) 2008-09-19 2014-02-18 Tandem Diabetes Care, Inc. Solute concentration measurement device and related methods
CA2742853C (en) * 2008-11-18 2019-01-08 3M Innovative Properties Company Hollow microneedle array and method
US20110301628A1 (en) * 2008-12-05 2011-12-08 Yossi Gross Techniques for use with a nail penetration device
KR101004014B1 (en) 2008-12-18 2010-12-31 (주)마이티시스템 Structure of a Micro-needle with a Side Channel, and Manufacturing Method of the Same
US20110021996A1 (en) * 2008-12-18 2011-01-27 Miti Systems Inc. Structure of micro-needle with side channel and manufacturing method thereof
KR20110119640A (en) 2008-12-22 2011-11-02 마이오우사이언스, 인크. Integrated cryosurgical system with refrigerant and electrical power source
WO2010078323A1 (en) * 2008-12-29 2010-07-08 Sung-Yun Kwon Method of manufacturing solid solution peforator patches and uses thereof
US9084784B2 (en) 2009-01-06 2015-07-21 Curelon Llc Compositions and methods for the treatment or the prevention of E. coli infections and for the eradication or reduction of E. coli surfaces
GB2480772B (en) 2009-01-06 2013-10-16 Curelon Llc Compositions and methods for the treatment or prevention of staphylococcus aureus infections and for the eradication or reduction of staphylococcus aureus
WO2010087971A2 (en) 2009-01-27 2010-08-05 California Institute Of Technology Drug delivery and substance transfer facilitated by nano-enhanced device having aligned carbon nanotubes protruding from device surface
US9375169B2 (en) 2009-01-30 2016-06-28 Sanofi-Aventis Deutschland Gmbh Cam drive for managing disposable penetrating member actions with a single motor and motor and control system
US9402544B2 (en) 2009-02-03 2016-08-02 Abbott Diabetes Care Inc. Analyte sensor and apparatus for insertion of the sensor
US8961492B2 (en) 2009-02-12 2015-02-24 Incube Labs, Llc System and method for controlling the iontophoretic delivery of therapeutic agents based on user inhalation
US8190252B2 (en) 2009-02-12 2012-05-29 Incube Labs, Llc Iontophoretic system for transdermal delivery of active agents for therapeutic and medicinal purposes
US8348922B2 (en) * 2009-02-12 2013-01-08 Incube Labs, Llc Method and apparatus for oscillatory iontophoretic transdermal delivery of a therapeutic agent
US9095503B2 (en) 2009-02-12 2015-08-04 Incube Labs, Llc System and method for biphasic transdermal iontophreotic delivery of therapeutic agents
JP5653942B2 (en) 2009-02-26 2015-01-14 ザ ユニバーシティ オブ ノース キャロライナ アット チャペル ヒル Intervention drug delivery system
WO2012018486A2 (en) 2010-07-26 2012-02-09 Seventh Sense Biosystems, Inc. Rapid delivery and/or receiving of fluids
US8827971B2 (en) 2011-04-29 2014-09-09 Seventh Sense Biosystems, Inc. Delivering and/or receiving fluids
WO2010101620A2 (en) 2009-03-02 2010-09-10 Seventh Sense Biosystems, Inc. Systems and methods for creating and using suction blisters or other pooled regions of fluid within the skin
JP5563652B2 (en) * 2009-03-17 2014-07-30 カーディオスライヴ インコーポレイテッド External defibrillator
US8781576B2 (en) 2009-03-17 2014-07-15 Cardiothrive, Inc. Device and method for reducing patient transthoracic impedance for the purpose of delivering a therapeutic current
CN101829396B (en) * 2009-03-27 2013-01-30 清华大学 Micro-needle array chip and percutaneous administration patch using same and preparation method thereof
US9056050B2 (en) 2009-04-13 2015-06-16 Curemark Llc Enzyme delivery systems and methods of preparation and use
NZ619320A (en) 2009-04-22 2015-08-28 Mercator Medsystems Inc Use of guanethidine for treating hypertension by local vascular delivery
US8821945B2 (en) * 2009-04-25 2014-09-02 Fe3 Medical, Inc. Method for transdermal iontophoretic delivery of chelated agents
US8888757B2 (en) * 2009-05-27 2014-11-18 Wisconsin Alumni Research Foundation Active microneedle array
US8423131B2 (en) * 2009-06-26 2013-04-16 Incube Labs, Llc Corrosion resistant electrodes for iontophoretic transdermal delivery devices and methods of use
US8613892B2 (en) 2009-06-30 2013-12-24 Abbott Diabetes Care Inc. Analyte meter with a moveable head and methods of using the same
KR101213223B1 (en) * 2009-07-07 2013-01-09 한국전자통신연구원 The method for manufacturing hallow microneedle structures
US8404728B2 (en) 2009-07-30 2013-03-26 Mayo Foundation For Medical Education And Research Small-molecule botulinum toxin inhibitors
CA2769030C (en) 2009-07-30 2016-05-10 Tandem Diabetes Care, Inc. Infusion pump system with disposable cartridge having pressure venting and pressure feedback
US8903485B2 (en) 2009-08-06 2014-12-02 Incube Labs, Llc Patch and patch assembly for iontophoretic transdermal delivery of active agents for therapeutic and medicinal purposes
US11096708B2 (en) 2009-08-07 2021-08-24 Ulthera, Inc. Devices and methods for performing subcutaneous surgery
US9358064B2 (en) 2009-08-07 2016-06-07 Ulthera, Inc. Handpiece and methods for performing subcutaneous surgery
US8088108B2 (en) * 2009-08-22 2012-01-03 Joseph Wayne Kraft Rapid local anesthesia injection cone
JP2011045565A (en) * 2009-08-27 2011-03-10 Nanbu Plastics Co Ltd Liquid medicine injector
EP2473963A4 (en) 2009-08-31 2014-01-08 Abbott Diabetes Care Inc Medical devices and methods
MX2012004620A (en) 2009-10-19 2012-06-25 Theranos Inc Integrated health data capture and analysis system.
US8834423B2 (en) 2009-10-23 2014-09-16 University of Pittsburgh—of the Commonwealth System of Higher Education Dissolvable microneedle arrays for transdermal delivery to human skin
AU2010313487A1 (en) 2009-10-26 2012-05-24 Emkinetics, Inc. Method and apparatus for electromagnetic stimulation of nerve, muscle, and body tissues
EP2499282B1 (en) 2009-11-09 2015-04-22 NeuroGenetic Pharmaceuticals, Inc. Gamma-secretase modulatory compounds, methods for identifying same, and uses therefor
EP2506768B1 (en) 2009-11-30 2016-07-06 Intuity Medical, Inc. Calibration material delivery devices and methods
WO2011069002A1 (en) 2009-12-02 2011-06-09 Alquest Therapeutics, Inc. Organoselenium compounds and uses thereof
US8685038B2 (en) 2009-12-07 2014-04-01 Incube Labs, Llc Iontophoretic apparatus and method for marking of the skin
KR101224939B1 (en) * 2009-12-07 2013-01-22 가천대학교 산학협력단 Microneedle Having Improved Absorption Rate Of Active Agent
US20110144591A1 (en) * 2009-12-11 2011-06-16 Ross Russell F Transdermal Delivery Device
SG181896A1 (en) * 2009-12-23 2012-07-30 Map Pharmaceuticals Inc Novel ergoline analogs
US8454975B1 (en) 2010-01-11 2013-06-04 Elizabeth VanderVeer Method for enhancing skin appearance
WO2011094573A1 (en) 2010-01-28 2011-08-04 Seventh Sense Biosystems, Inc. Monitoring or feedback systems and methods
US9014779B2 (en) 2010-02-01 2015-04-21 Proteus Digital Health, Inc. Data gathering system
USD924406S1 (en) 2010-02-01 2021-07-06 Abbott Diabetes Care Inc. Analyte sensor inserter
EP2531096A4 (en) 2010-02-01 2013-09-11 Proteus Digital Health Inc Two-wrist data gathering system
US8986279B2 (en) 2010-02-10 2015-03-24 Incube Labs, Llc Methods and architecture for power optimization of iontophoretic transdermal drug delivery
EP2549918B2 (en) 2010-03-24 2023-01-25 Abbott Diabetes Care, Inc. Medical device inserters and processes of inserting and using medical devices
US9115424B2 (en) 2010-04-07 2015-08-25 California Institute Of Technology Simple method for producing superhydrophobic carbon nanotube array
US8965476B2 (en) 2010-04-16 2015-02-24 Sanofi-Aventis Deutschland Gmbh Tissue penetration device
MX2012012567A (en) 2010-04-28 2012-11-21 Kimberly Clark Co Method for increasing permeability of an epithelial barrier.
US9526883B2 (en) 2010-04-28 2016-12-27 Kimberly-Clark Worldwide, Inc. Composite microneedle array including nanostructures thereon
EP2563451B1 (en) 2010-04-28 2017-11-01 Kimberly-Clark Worldwide, Inc. MEDICAL DEVICES FOR DELIVERY OF siRNA
DK2563450T3 (en) 2010-04-28 2017-11-13 Kimberly Clark Co Apparatus for administering rheumatoid arthritis drug
US8588884B2 (en) 2010-05-28 2013-11-19 Emkinetics, Inc. Microneedle electrode
TWI455722B (en) 2010-06-04 2014-10-11 Pfizer Vaccines Llc Conjugates for the prevention or treatment of nicotine addiction
WO2011163347A2 (en) 2010-06-23 2011-12-29 Seventh Sense Biosystems, Inc. Sampling devices and methods involving relatively little pain
EP2584964B1 (en) 2010-06-25 2021-08-04 Intuity Medical, Inc. Analyte monitoring devices
US11064921B2 (en) 2010-06-29 2021-07-20 Abbott Diabetes Care Inc. Devices, systems and methods for on-skin or on-body mounting of medical devices
US9943673B2 (en) 2010-07-14 2018-04-17 Vaxxas Pty Limited Patch applying apparatus
JP2013538069A (en) 2010-07-16 2013-10-10 セブンス センス バイオシステムズ，インコーポレーテッド Low pressure environment for fluid transfer devices
WO2012021801A2 (en) 2010-08-13 2012-02-16 Seventh Sense Biosystems, Inc. Systems and techniques for monitoring subjects
ES2353181B1 (en) * 2010-09-01 2012-02-17 Francisco Javier García Saban SEQUENTIAL MEASUREMENT DEVICE OF AN ANALYTE.
CN106214321B (en) 2010-10-15 2018-08-28 科尼尔赛德生物医学公司 Device for entering eyes
US8808202B2 (en) 2010-11-09 2014-08-19 Seventh Sense Biosystems, Inc. Systems and interfaces for blood sampling
TWI450707B (en) * 2010-11-09 2014-09-01 Univ Chung Hua Bio-impedance measurement apparatus and assembly
WO2012079066A2 (en) 2010-12-10 2012-06-14 California Institute Of Technology Method for producing graphene oxide with tunable gap
US8696637B2 (en) 2011-02-28 2014-04-15 Kimberly-Clark Worldwide Transdermal patch containing microneedles
WO2012135238A1 (en) 2011-03-29 2012-10-04 California Institute Of Technology Method to increase the capacitance of electrochemical carbon nanotube capacitors by conformal deposition of nanoparticles
US10244981B2 (en) * 2011-03-30 2019-04-02 SensiVida Medical Technologies, Inc. Skin test image analysis apparatuses and methods thereof
MX362974B (en) 2011-04-21 2019-02-28 Curemark Llc Compounds for the treatment of neuropsychiatric disorders.
WO2012149155A1 (en) 2011-04-29 2012-11-01 Seventh Sense Biosystems, Inc. Systems and methods for collecting fluid from a subject
US20130158468A1 (en) 2011-12-19 2013-06-20 Seventh Sense Biosystems, Inc. Delivering and/or receiving material with respect to a subject surface
CA2833175A1 (en) 2011-04-29 2012-11-01 Seventh Sense Biosystems, Inc. Devices and methods for collection and/or manipulation of blood spots or other bodily fluids
WO2012154704A2 (en) 2011-05-06 2012-11-15 Incube Labs, Llc System and method for biphasic transdermal iontophoretic delivery of therapeutic agents for the control of addictive cravings
JP5908977B2 (en) 2011-06-14 2016-04-26 ジョンジュ ナ Apparatus and method for improving skin with Lar effect or Laplacian effect
MX2013015373A (en) 2011-06-23 2014-02-11 Map Pharmaceuticals Inc Novel fluoroergoline analogs.
DK3473296T3 (en) 2011-06-28 2020-11-09 Inovio Pharmaceuticals Inc MINIMALLY INVASIVE DERMAL ELECTROPORATION UNIT
EP4339613A2 (en) 2011-08-03 2024-03-20 Intuity Medical, Inc. Body fluid sampling arrangement
WO2013037482A1 (en) 2011-09-15 2013-03-21 Phenex Pharmaceuticals Ag Farnesoid x receptor agonists for cancer treatment and prevention
AU2012323782B2 (en) * 2011-10-12 2017-04-06 Vaxxas Pty Limited Delivery device
AU2012325801B2 (en) 2011-10-19 2016-05-12 Mercator Medsystems, Inc. Localized modulation of tissues and cells to enhance therapeutic effects including renal denervation
US20170246439A9 (en) 2011-10-27 2017-08-31 Kimberly-Clark Worldwide, Inc. Increased Bioavailability of Transdermally Delivered Agents
DK3542851T3 (en) 2011-10-27 2022-03-14 Sorrento Therapeutics Inc IMPLANTABLE DEVICES FOR DELIVERING BIOACTIVE MEANS
JP6100271B2 (en) 2011-10-27 2017-03-22 キンバリー クラーク ワールドワイド インコーポレイテッド Transdermal delivery of highly viscous bioactive agents
GB201120000D0 (en) 2011-11-20 2012-01-04 Glaxosmithkline Biolog Sa Vaccine
GB201119999D0 (en) 2011-11-20 2012-01-04 Glaxosmithkline Biolog Sa Vaccine
JP2013106831A (en) * 2011-11-22 2013-06-06 Toppan Printing Co Ltd Method for manufacturing needle shape body, and transfer plate for needle shape body
EP4056105B1 (en) 2011-12-11 2023-10-11 Abbott Diabetes Care, Inc. Analyte sensor devices
WO2013090844A1 (en) 2011-12-14 2013-06-20 California Institute Of Technology Sharp tip carbon nanotube microneedle devices and their fabrication
SG11201403434YA (en) 2011-12-19 2014-09-26 Map Pharmaceuticals Inc Novel iso-ergoline derivatives
AU2012355983A1 (en) 2011-12-21 2015-01-22 Map Pharmaceuticals, Inc. Novel neuromodulatory compounds
CA2861116A1 (en) 2012-01-13 2013-07-18 Myoscience, Inc. Cryogenic probe filtration system
US9314290B2 (en) 2012-01-13 2016-04-19 Myoscience, Inc. Cryogenic needle with freeze zone regulation
BR112014017175A8 (en) 2012-01-13 2017-07-04 Myoscience Inc skin protection for subdermal cryogenic remodeling for cosmetic and other treatments
US9017318B2 (en) 2012-01-20 2015-04-28 Myoscience, Inc. Cryogenic probe system and method
JP2015513104A (en) 2012-04-04 2015-04-30 ユニバーシティ・オブ・シンシナティ Sweat simulation, collection and sensing system
US9681836B2 (en) 2012-04-23 2017-06-20 Cyberonics, Inc. Methods, systems and apparatuses for detecting seizure and non-seizure states
CA3077452C (en) 2012-05-01 2022-08-09 University Of Pittsburgh-Of The Commonwealth System Of Higher Education Tip-loaded microneedle arrays for transdermal insertion
LT2844637T (en) 2012-05-02 2018-05-10 Boehringer Ingelheim International Gmbh Substituted 3-haloallylamine inhibitors of ssao and uses thereof
US9180242B2 (en) 2012-05-17 2015-11-10 Tandem Diabetes Care, Inc. Methods and devices for multiple fluid transfer
DE102012010262B4 (en) * 2012-05-25 2014-07-03 Albrecht Molsberger Therapeutically applicable DC delivery device
US10350278B2 (en) 2012-05-30 2019-07-16 Curemark, Llc Methods of treating Celiac disease
EP3406598B1 (en) 2012-06-14 2020-01-29 Mayo Foundation for Medical Education and Research Pyrazole derivatives as inhibitors of stat3
US9012640B2 (en) 2012-06-22 2015-04-21 Map Pharmaceuticals, Inc. Cabergoline derivatives
WO2014022314A1 (en) 2012-07-30 2014-02-06 California Institute Of Technology Nano tri-carbon composite systems and manufacture
US20140037680A1 (en) 2012-08-06 2014-02-06 Glaxosmithkline Biologicals, S.A. Novel method
CA2879939A1 (en) 2012-08-06 2014-02-13 Glaxosmithkline Biologicals S.A. Novel method
US10980865B2 (en) 2012-08-10 2021-04-20 Aquavit Pharmaceuticals, Inc. Direct application system and method for the delivery of bioactive compositions and formulations
US9074186B2 (en) 2012-08-15 2015-07-07 Boston Medical Center Corporation Production of red blood cells and platelets from stem cells
MX2015005839A (en) 2012-11-08 2015-12-17 Clearside Biomedical Inc Methods and devices for the treatment of ocular diseases in human subjects.
EP2929333B1 (en) * 2012-12-07 2018-07-04 Ascilion AB A microfabricated sensor and a method of sensing the level of a component in bodily fluid
CA2932540A1 (en) * 2012-12-14 2014-06-19 The Trustees Of Columbia University In The City Of New York System and method to locally deliver therapeutic agent to inner ear
US10821276B2 (en) 2012-12-14 2020-11-03 The Trustees Of Columbia University In The City Of New York System and method to locally deliver therapeutic agent to inner ear
CA2892587A1 (en) 2012-12-14 2014-06-19 Mindera Corporation Methods and devices for detection and acquisition of biomarkers
BR112015014964A2 (en) 2012-12-21 2017-07-11 Map Pharmaceuticals Inc new methysergide derivatives
US9169214B2 (en) 2012-12-21 2015-10-27 The Board Of Trustees Of The Leland Stanford Junior University Compounds and compositions that bind and stabilize transthyretin and their use for inhibiting transthyretin amyloidosis and protein-protein interactions
WO2014120114A1 (en) * 2013-01-29 2014-08-07 Empire Technology Development Llc Microneedle-based natremia sensor and methods of use
WO2014153164A1 (en) 2013-03-14 2014-09-25 The California Institute For Biomedical Research Targeting agent antibody conjugates and uses thereof
US10820860B2 (en) 2013-03-14 2020-11-03 One Drop Biosensor Technologies, Llc On-body microsensor for biomonitoring
US9182368B2 (en) 2013-03-14 2015-11-10 Sano Intelligence, Inc. Method of manufacturing a sensor for sensing analytes
US9173998B2 (en) 2013-03-14 2015-11-03 Tandem Diabetes Care, Inc. System and method for detecting occlusions in an infusion pump
WO2014146127A1 (en) 2013-03-15 2014-09-18 Myoscience, Inc. Methods and systems for treatment of spasticity
US9610112B2 (en) 2013-03-15 2017-04-04 Myoscience, Inc. Cryogenic enhancement of joint function, alleviation of joint stiffness and/or alleviation of pain associated with osteoarthritis
US20140350536A1 (en) 2013-03-15 2014-11-27 Myoscience, Inc. Cryogenic Blunt Dissection Methods and Devices
US9295512B2 (en) 2013-03-15 2016-03-29 Myoscience, Inc. Methods and devices for pain management
CN105246529B (en) 2013-05-03 2019-06-14 科尼尔赛德生物医学公司 Device and method for ocular injection
US10188550B2 (en) 2013-06-03 2019-01-29 Clearside Biomedical, Inc. Apparatus and methods for drug delivery using multiple reservoirs
ES2891755T3 (en) 2013-06-06 2022-01-31 Pf Medicament Anti-C10orf54 antibodies and uses thereof
EP3007841A4 (en) 2013-06-13 2017-02-22 Microdermics Inc. Metallic microneedles
US10279189B2 (en) 2013-06-14 2019-05-07 Cardiothrive, Inc. Wearable multiphasic cardioverter defibrillator system and method
US9656094B2 (en) 2013-06-14 2017-05-23 Cardiothrive, Inc. Biphasic or multiphasic pulse generator and method
US10149973B2 (en) 2013-06-14 2018-12-11 Cardiothrive, Inc. Multipart non-uniform patient contact interface and method of use
US9616243B2 (en) 2013-06-14 2017-04-11 Cardiothrive, Inc. Dynamically adjustable multiphasic defibrillator pulse system and method
US9833630B2 (en) 2013-06-14 2017-12-05 Cardiothrive, Inc. Biphasic or multiphasic pulse waveform and method
US9907970B2 (en) 2013-06-14 2018-03-06 Cardiothrive, Inc. Therapeutic system and method using biphasic or multiphasic pulse waveform
US10729386B2 (en) 2013-06-21 2020-08-04 Intuity Medical, Inc. Analyte monitoring system with audible feedback
CN103330562B (en) * 2013-07-11 2015-01-28 无锡交大联云科技有限公司 Bionic flexible dry electrode and manufacturing method thereof
AU2014304545A1 (en) 2013-08-05 2016-02-25 Glaxosmithkline Biologicals S.A. Combination immunogenic compositions
US11185271B2 (en) 2013-09-13 2021-11-30 University Of Utah Research Foundation Methods of making micro-molded electrodes and arrays
DE102013219432A1 (en) * 2013-09-26 2015-03-26 Peter Röhr Blood collection device and method for withdrawing blood
JP2016533227A (en) 2013-10-18 2016-10-27 ユニバーシティ・オブ・シンシナティ Sweat perception with a guarantee over time
WO2015058055A1 (en) 2013-10-18 2015-04-23 University Of Cincinnati Devices for integrated, repeated, prolonged, and/or reliable sweat stimulation and biosensing
US10888244B2 (en) 2013-10-18 2021-01-12 University Of Cincinnati Sweat sensing with chronological assurance
US10130409B2 (en) 2013-11-05 2018-11-20 Myoscience, Inc. Secure cryosurgical treatment system
EP3082761A2 (en) 2013-12-20 2016-10-26 Emory University Formulations and methods for targeted ocular delivery of therapeutic agents
GB201403775D0 (en) 2014-03-04 2014-04-16 Kymab Ltd Antibodies, uses & methods
US9828284B2 (en) 2014-03-28 2017-11-28 Ut-Battelle, Llc Thermal history-based etching
US20160279401A1 (en) 2015-03-27 2016-09-29 Allergan, Inc. Dissolvable microneedles for skin treatment
EP3148430A4 (en) 2014-05-28 2018-05-16 University of Cincinnati Advanced sweat sensor adhesion, sealing, and fluidic strategies
US10639015B2 (en) 2014-05-28 2020-05-05 University Of Cincinnati Devices with reduced sweat volumes between sensors and sweat glands
MA47849A (en) 2014-05-28 2020-01-29 Agenus Inc ANTI-GITR ANTIBODIES AND THEIR METHODS OF USE
EP3148420A4 (en) 2014-05-28 2018-09-19 University of Cincinnati Sweat monitoring and control of drug delivery
JP6664338B2 (en) 2014-06-13 2020-03-13 グラクソスミスクライン バイオロジカルズ ソシエテ アノニム Immunogenic combination
WO2015196085A2 (en) 2014-06-20 2015-12-23 Clearside Biomedical, Inc. Variable diameter cannula and methods for controlling insertion depth for medicament delivery
JP6543342B2 (en) 2014-08-14 2019-07-10 アルハマドシャー，マモウン，エム． Conjugation of a pharmaceutically active agent with a transthyretin ligand via a regulatable linker to extend serum half life
US10321858B2 (en) 2014-08-18 2019-06-18 Proteadx, Inc. Apparatus and methods for transdermal sensing of analytes in interstitial fluid and associated data transmission systems
EA201790434A1 (en) 2014-08-22 2017-07-31 Окленд Юнисервисиз Лимитед CHANNEL MODULATORS
CA2962340A1 (en) 2014-09-22 2016-03-31 University Of Cincinnati Sweat sensing with analytical assurance
USD750223S1 (en) 2014-10-14 2016-02-23 Clearside Biomedical, Inc. Medical injector for ocular injection
CN107073249B (en) * 2014-10-17 2021-01-01 花王株式会社 Method for producing fine hollow projections
JP6126658B2 (en) * 2015-08-17 2017-05-10 花王株式会社 Method for producing fine hollow projection
JP6586329B2 (en) * 2015-08-17 2019-10-02 花王株式会社 Method for producing fine hollow projection
WO2016060020A1 (en) * 2014-10-17 2016-04-21 花王株式会社 Fine hollow protrusion manufacturing method
JP6906885B2 (en) 2014-11-14 2021-07-21 ロレアル Microneedle sheet to reduce wrinkles
PT3800202T (en) 2014-12-11 2023-01-05 Pf Medicament Anti-c10orf54 antibodies and uses thereof
EP3237450B1 (en) 2014-12-22 2021-03-03 The Rockefeller University Anti-mertk agonistic antibodies and uses thereof
US9676776B2 (en) 2015-01-20 2017-06-13 Xoc Pharmaceuticals, Inc. Isoergoline compounds and uses thereof
JP6856532B2 (en) 2015-01-20 2021-04-07 エックスオーシー ファーマシューティカルズ インコーポレイテッドＸｏｃ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ， Ｉｎｃ Ergoline compounds and their use
CA3204959A1 (en) 2015-02-02 2016-08-11 Vaxxas Pty Limited Microprojection array applicator and method
CN111067544B (en) 2015-02-13 2023-04-07 辛辛那提大学 Device integrating indirect sweat stimulation and sensing
BR112017015880A2 (en) 2015-03-03 2018-07-31 Kymab Ltd antibodies, uses and methods
US10441768B2 (en) 2015-03-18 2019-10-15 University of Pittsburgh—of the Commonwealth System of Higher Education Bioactive components conjugated to substrates of microneedle arrays
WO2016176617A2 (en) 2015-04-29 2016-11-03 New York University Method for treating high-grade gliomas
US10213139B2 (en) 2015-05-14 2019-02-26 Abbott Diabetes Care Inc. Systems, devices, and methods for assembling an applicator and sensor control device
CA2984939A1 (en) 2015-05-14 2016-11-17 Abbott Diabetes Care Inc. Compact medical device inserters and related systems and methods
PE20180672A1 (en) 2015-05-29 2018-04-19 Agenus Inc ANTI-CTLA-4 ANTIBODIES AND METHODS OF USE OF THE SAME
US10646142B2 (en) 2015-06-29 2020-05-12 Eccrine Systems, Inc. Smart sweat stimulation and sensing devices
JP6586317B2 (en) * 2015-08-19 2019-10-02 花王株式会社 Fine projection tool and manufacturing method thereof
WO2017040790A1 (en) 2015-09-01 2017-03-09 Agenus Inc. Anti-pd-1 antibodies and methods of use thereof
US11103259B2 (en) 2015-09-18 2021-08-31 Vaxxas Pty Limited Microprojection arrays with microprojections having large surface area profiles
WO2017066768A1 (en) 2015-10-16 2017-04-20 University Of Pittsburgh-Of The Commonwealth System Of Higher Education Mullti-component biio-active drug delivery and controlled release to the skin by microneedle array devices
CN108697322A (en) 2015-10-23 2018-10-23 外分泌腺系统公司 The device that can carry out sample concentration of extension sensing for sweat analyte
AU2015249138A1 (en) * 2015-10-29 2017-05-18 Winter, Paul Nicholas MR A system delivering medications of providing drainage along tubes linked to central container using arrays of special fenestrated hypodermic needles.
US10112924B2 (en) 2015-12-02 2018-10-30 Astraea Therapeutics, Inc. Piperdinyl nociceptin receptor compounds
US10674946B2 (en) 2015-12-18 2020-06-09 Eccrine Systems, Inc. Sweat sensing devices with sensor abrasion protection
US11744889B2 (en) 2016-01-05 2023-09-05 University of Pittsburgh—of the Commonwealth System of Higher Education Skin microenvironment targeted delivery for promoting immune and other responses
JP2017131397A (en) * 2016-01-27 2017-08-03 花王株式会社 Method of producing fine, and hollow projection tool
EP3413851B1 (en) 2016-02-10 2023-09-27 Clearside Biomedical, Inc. Packaging
WO2017143153A1 (en) * 2016-02-19 2017-08-24 North Carolina State University Methods and compositions related to physiologically responsive microneedle delivery systems
JP2019513070A (en) 2016-03-01 2019-05-23 キトテック メディカル， インコーポレイテッド Microstructure-based systems, devices and methods for wound closure
EP4137116A1 (en) 2016-03-01 2023-02-22 Georgia Tech Research Corporation Composition comprising microneedle particles
WO2017151836A1 (en) 2016-03-04 2017-09-08 East Carolina University J-series prostaglandin-ethanolamides as novel therapeutics for skin and/or oral disorders
US10407437B2 (en) 2016-03-08 2019-09-10 Los Gatos Pharmaceuticals, Inc. Camptothecin derivatives and uses thereof
WO2017156191A1 (en) 2016-03-08 2017-09-14 Los Gatos Pharmaceuticals, Inc. Composite nanoparticles and uses thereof
JP2017176652A (en) 2016-03-31 2017-10-05 花王株式会社 Minute hollow projection tool
US10047077B2 (en) 2016-04-13 2018-08-14 Skyline Antiinfectives, Inc. Deuterated O-sulfated beta-lactam hydroxamic acids and deuterated N-sulfated beta-lactams
JP2019514581A (en) 2016-05-02 2019-06-06 クリアサイド バイオメディカル，インコーポレイテッド Systems and methods for ocular drug delivery
EP4190357A1 (en) 2016-05-13 2023-06-07 Institut Pasteur Inhibition of beta-2 nicotinic acetylcholine receptors to treat alzheimer's disease pathology
EP3454762B1 (en) 2016-05-13 2024-04-03 Pacira CryoTech, Inc. Systems for locating and treating with cold therapy
MX2018014387A (en) 2016-05-27 2019-03-14 Agenus Inc Anti-tim-3 antibodies and methods of use thereof.
US10471249B2 (en) 2016-06-08 2019-11-12 University Of Cincinnati Enhanced analyte access through epithelial tissue
US20190177438A1 (en) 2016-06-17 2019-06-13 Life Technologies Corporation Site-Specific Crosslinking of Antibodies
US11253190B2 (en) 2016-07-01 2022-02-22 University Of Cincinnati Devices with reduced microfluidic volume between sensors and sweat glands
MA45602A (en) 2016-07-08 2019-05-15 Staten Biotechnology B V ANTI-APOC3 ANTIBODIES AND THEIR METHODS OF USE
CN110035690A (en) 2016-07-19 2019-07-19 外分泌腺系统公司 Sweat conductivity, volume perspiration rate and electrodermal response equipment and application
CN109562259B (en) * 2016-08-11 2023-06-27 领先仿生公司 Cochlear implant comprising electrode array and method for manufacturing electrode array
US10973681B2 (en) 2016-08-12 2021-04-13 Clearside Biomedical, Inc. Devices and methods for adjusting the insertion depth of a needle for medicament delivery
US10919904B2 (en) 2016-08-17 2021-02-16 North Carolina State University Northern-southern route to synthesis of bacteriochlorins
AU2017343621B2 (en) 2016-10-11 2021-12-02 Agenus Inc. Anti-LAG-3 antibodies and methods of use thereof
US10736565B2 (en) 2016-10-14 2020-08-11 Eccrine Systems, Inc. Sweat electrolyte loss monitoring devices
US11779604B2 (en) 2016-11-03 2023-10-10 Kymab Limited Antibodies, combinations comprising antibodies, biomarkers, uses and methods
KR102539159B1 (en) 2016-11-07 2023-06-02 주식회사 뉴라클사이언스 Anti-family with sequence similarity 19, member a5 antibodies and method of use thereof
WO2018089692A1 (en) 2016-11-09 2018-05-17 Phloronol, Inc. Eckol derivatives, methods of synthesis and uses thereof
EP3541358A1 (en) * 2016-11-21 2019-09-25 Eirion Therapeutics, Inc. Transdermal delivery of large agents
WO2018102252A1 (en) 2016-11-30 2018-06-07 North Carolina State University Methods for making bacteriochlorin macrocycles comprising an annulated isocyclic ring and related compounds
EP3551225A1 (en) 2016-12-07 2019-10-16 Agenus Inc. Antibodies and methods of use thereof
SI3551660T1 (en) 2016-12-07 2024-02-29 Agenus Inc. Anti-ctla-4 antibodies and methods of use thereof
CN110461217B (en) 2017-01-23 2022-09-16 雅培糖尿病护理公司 Systems, devices, and methods for analyte sensor insertion
EP3576833A1 (en) * 2017-01-31 2019-12-11 SABIC Global Technologies B.V. Using film to provide a preform for micro injection molding process
KR102401856B1 (en) 2017-02-17 2022-05-26 알레간 인코포레이티드 Microneedle Array with Active Ingredient
BR112019017260A2 (en) 2017-02-17 2020-04-14 Camris Int Inc universal antivenom
NZ755597A (en) 2017-02-17 2023-06-30 Eidos Therapeutics Inc Processes for preparing ag-10, its intermediates, and salts thereof
CN107007927A (en) * 2017-02-21 2017-08-04 中山大学 A kind of microneedle array drug paste and preparation method being administered based on electric field driven
US10952654B2 (en) 2017-03-14 2021-03-23 International Business Machines Corporation PH sensitive surgical tool
DK3606760T3 (en) 2017-03-31 2023-11-06 Vaxxas Pty Ltd ARRANGEMENT AND PROCEDURE FOR COATING SURFACES
AU2018253176B2 (en) 2017-04-13 2023-02-02 Agenus Inc. Anti-CD137 antibodies and methods of use thereof
CA3059133A1 (en) 2017-04-21 2018-10-25 Staten Biotechnology B.V. Anti-apoc3 antibodies and methods of use thereof
US10406358B1 (en) * 2017-04-24 2019-09-10 Todd M. Bertoch Chronic pain treatment device
HRP20230941T1 (en) 2017-05-01 2023-11-24 Agenus Inc. Anti-tigit antibodies and methods of use thereof
US10085999B1 (en) 2017-05-10 2018-10-02 Arixa Pharmaceuticals, Inc. Beta-lactamase inhibitors and uses thereof
AU2018275672A1 (en) 2017-05-31 2020-01-16 Texas Tech University System Methods and devices for the treatment of food allergies
CA3064274A1 (en) 2017-06-01 2018-12-06 Xoc Pharmaceuticals, Inc. Ergoline derivatives for use in medicine
US11175128B2 (en) 2017-06-13 2021-11-16 Vaxxas Pty Limited Quality control of substrate coatings
EP3645029B1 (en) 2017-06-26 2023-01-18 Institut Pasteur Treatments to eliminate hiv reservoirs and reduce viral load
WO2019003162A1 (en) 2017-06-27 2019-01-03 Neuracle Science Co., Ltd. Use of anti-family with sequence similarity 19, member a5 antibodies for the treatment of glaucoma
CN111315774B (en) 2017-06-27 2023-12-22 纽洛可科学有限公司 anti-FAM 19A5 antibodies and uses thereof
US11155613B2 (en) 2017-06-27 2021-10-26 Neuracle Science Co., Ltd. Use of anti-FAM19A5 antibodies for treating fibrosis
EP3645040A4 (en) 2017-06-27 2021-05-05 Neuracle Science Co., Ltd Use of anti-fam19a5 antibodies for treating cancers
EP4218893A1 (en) 2017-08-04 2023-08-02 Vaxxas Pty Limited Compact high mechanical energy storage and low trigger force actuator for the delivery of microprojection array patches (map)
CN110769891A (en) * 2017-08-17 2020-02-07 考司美德制药株式会社 Microneedle array for lips
AU2018324070B2 (en) 2017-09-01 2023-05-18 East Carolina University Compounds, compositions, kits, and methods for activating immune cells and/or an immune system response
WO2019075380A1 (en) * 2017-10-12 2019-04-18 Northwestern University Targeted delivery of biologic therapeutic agents
JP7039694B2 (en) 2017-10-31 2022-03-22 スターテン・バイオテクノロジー・ベー・フェー Anti-APOC3 antibody and how to use it
WO2019099677A1 (en) 2017-11-15 2019-05-23 Myoscience, Inc. Integrated cold therapy and electrical stimulation systems for locating and treating nerves and associated methods
JP2021504491A (en) 2017-11-29 2021-02-15 コペルニクス セラピューティクス インコーポレーティッド Gene therapy methods for improving the eyes
US10828500B2 (en) 2017-12-22 2020-11-10 Cardiothrive, Inc. External defibrillator
US11844919B2 (en) 2018-01-03 2023-12-19 The Trustees Of Columbia University In The City Of New York Microneedle for local delivery of therapeutic agent
KR20200135996A (en) 2018-03-23 2020-12-04 에이도스 테라퓨틱스, 인코포레이티드 How to use AG10 to treat TTR amyloidosis
CN112424223A (en) 2018-04-24 2021-02-26 纽洛可科学有限公司 Use of an antibody against member a5 of sequence similarity family 19 for the treatment of neuropathic pain
US11460411B2 (en) * 2018-06-18 2022-10-04 Kindeva Drug Delivery L.P. Process and apparatus for inspecting microneedle arrays
MA53160A (en) 2018-07-20 2021-05-26 Pf Medicament RECEIVER FOR VISTA
US11260047B2 (en) 2018-08-17 2022-03-01 Eidos Therapeutics, Inc. Formulations of AG10
WO2020069567A1 (en) * 2018-10-02 2020-04-09 WearOptimo Pty Ltd Electrode arrangement
CN112969503A (en) 2018-10-03 2021-06-15 斯塔滕生物技术有限公司 Antibodies specific for human and cynomolgus macaques APOC3 and methods of use thereof
AU2019379325A1 (en) 2018-11-16 2021-06-03 Genexine, Inc. Method of treating a tumor with a combination of IL-7 protein and an immune checkpoint inhibitor
WO2020128033A1 (en) 2018-12-20 2020-06-25 Institut Pasteur Cellular metabolism of hiv-1 reservoir seeding in cd4+ t cells
TW202045481A (en) 2019-02-06 2020-12-16 美商戴斯阿爾法股份有限公司 Il-17a modulators and uses thereof
US11464908B2 (en) 2019-02-18 2022-10-11 Tandem Diabetes Care, Inc. Methods and apparatus for monitoring infusion sites for ambulatory infusion pumps
EP3930847B1 (en) 2019-02-26 2024-02-14 Inspirna, Inc. High-affinity anti-mertk antibodies and uses thereof
TWI687247B (en) 2019-05-15 2020-03-11 微邦科技股份有限公司 Microneedle structure and biodegradable microneedle thereof
CN111939452A (en) * 2019-05-15 2020-11-17 微邦科技股份有限公司 Microneedle structure and biodegradable microneedle thereof
CA3138403A1 (en) 2019-05-20 2020-11-26 Christopher J. MACNEVIN Narrow emission dyes, compositions comprising same, and methods for making and using same
USD1002852S1 (en) 2019-06-06 2023-10-24 Abbott Diabetes Care Inc. Analyte sensor device
WO2021010879A1 (en) * 2019-07-12 2021-01-21 Ascilion Ab Integrated sensor assembly unit
CN110478613B (en) * 2019-08-22 2022-08-09 京东方科技集团股份有限公司 Device for delivering a formulation, apparatus and method of making a needle array in a device
CN114585644A (en) 2019-08-30 2022-06-03 艾吉纳斯公司 anti-CD 96 antibodies and methods of use thereof
MX2022003166A (en) 2019-09-16 2022-06-29 Dice Alpha Inc Il-17a modulators and uses thereof.
CN114945409A (en) 2020-01-13 2022-08-26 新免疫技术有限公司 Methods of treating tumors with combinations of IL-7 proteins and bispecific antibodies
AU2021217373A1 (en) 2020-02-05 2022-08-04 Neoimmunetech, Inc. Method of treating a solid tumor with a combination of an IL-7 protein and CAR-bearing immune cells
US11202753B1 (en) 2020-03-06 2021-12-21 Aquavit Pharmaceuticals, Inc. Systems and methods for generating immune responses in subjects using microchannel delivery devices
WO2021225826A1 (en) * 2020-05-06 2021-11-11 The Regents Of The University Of California Bioorthogonal catalytic patch and methods of using the same
US11911595B2 (en) 2020-05-18 2024-02-27 Tandem Diabetes Care, Inc. Systems and methods for automated insulin delivery response to meal announcements
JP6846560B2 (en) * 2020-06-04 2021-03-24 花王株式会社 Fine hollow protrusion
CN111729189B (en) * 2020-06-29 2023-01-06 嘉兴尚牧智能装备有限公司 Silicon-based patch and preparation method thereof
WO2022026764A1 (en) 2020-07-29 2022-02-03 Biolinq Inc. Continuous analyte monitoring system with microneedle array
US11541009B2 (en) 2020-09-10 2023-01-03 Curemark, Llc Methods of prophylaxis of coronavirus infection and treatment of coronaviruses
US20230398184A1 (en) 2020-10-26 2023-12-14 Neoimmunetech, Inc. Methods of inducing stem cell mobilization
US20240101629A1 (en) 2020-11-02 2024-03-28 Neoimmunetech, Inc. Use of interleukin-7 for the treatment of coronavirus
KR20230104175A (en) 2020-11-05 2023-07-07 네오이뮨텍, 인코퍼레이티드 Methods of Treating Tumors Using Combinations of IL-7 Protein and Nucleotide Vaccines
USD999913S1 (en) 2020-12-21 2023-09-26 Abbott Diabetes Care Inc Analyte sensor inserter
CN117642396A (en) 2021-03-10 2024-03-01 戴斯分子Sv有限公司 Alpha V beta 6 and alpha V beta 1 integrin inhibitors and uses thereof
SE545874C2 (en) 2021-05-08 2024-02-27 Biolinq Incorporated Fault detection for microneedle array based continuous analyte monitoring device
WO2022263357A1 (en) 2021-06-14 2022-12-22 Argenx Iip Bv Anti-il-9 antibodies and methods of use thereof
WO2023081923A1 (en) 2021-11-08 2023-05-11 Frequency Therapeutics, Inc. Platelet-derived growth factor receptor (pdgfr) alpha inhibitors and uses thereof
WO2023130081A1 (en) 2021-12-30 2023-07-06 Neoimmunetech, Inc. Method of treating a tumor with a combination of il-7 protein and vegf antagonist
WO2023129577A1 (en) 2022-01-03 2023-07-06 Lilac Therapeutics, Inc. Cyclic thiol prodrugs
GB2619907A (en) 2022-04-01 2023-12-27 Kanna Health Ltd Novel crystalline salt forms of mesembrine

Family Cites Families (114)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE541794A (en) 1954-10-04
US3964482A (en) 1971-05-17 1976-06-22 Alza Corporation Drug delivery device
DE2319591C2 (en) 1973-04-18 1982-02-25 Kirchner & Wilhelm, 7000 Stuttgart Medical apparatus
FR2232331B1 (en) 1973-06-06 1978-03-24 Guerin A Ets
AT347283B (en) 1975-03-07 1978-12-27 Collo Gmbh FOAM BODY FOR CLEANING, SCRUBBING AND / OR POLISHING PURPOSES AND THE LIKE.
US4180232A (en) 1977-01-13 1979-12-25 Hardigg James S Truss panel mold
US4381963A (en) 1980-07-30 1983-05-03 The University Of Rochester Micro fabrication molding process
US4585991A (en) 1982-06-03 1986-04-29 Texas Instruments Incorporated Solid state multiprobe testing apparatus
FR2535602B1 (en) 1982-11-05 1986-06-13 Stallergenes Lab SCARIFIER DEVICE
US5591123A (en) 1983-08-18 1997-01-07 Drug Delivery Systems Inc. Programmable control mounting system for transdermal drug applicator
US4708716A (en) * 1983-08-18 1987-11-24 Drug Delivery Systems Inc. Transdermal drug applicator
US4583982A (en) 1984-08-24 1986-04-22 Vlock D G Fluid dispenser
US5135477A (en) 1984-10-29 1992-08-04 Medtronic, Inc. Iontophoretic drug delivery
US4784737A (en) 1986-04-18 1988-11-15 The United States Department Of Energy Electromicroinjection of particles into living cells
US4837049A (en) 1986-06-17 1989-06-06 Alfred E. Mann Foundation For Scientific Research Method of making an electrode array
US5362307A (en) 1989-01-24 1994-11-08 The Regents Of The University Of California Method for the iontophoretic non-invasive-determination of the in vivo concentration level of an inorganic or organic substance
US5198192A (en) 1988-05-18 1993-03-30 Inax Corporation Apparatus for detecting ingredient in urine, a toilet stool equipped with a urine detecting device and a room for urine detecting facility
GB2221394B (en) 1988-08-05 1992-03-04 Eilert Eilertsen An injection device
SU1667864A1 (en) 1989-03-23 1991-08-07 Опытный завод энергетического машиностроения Electrostimulation device
US5134079A (en) 1989-03-27 1992-07-28 International Technidyne Corp. Fluid sample collection and delivery system and methods particularly adapted for body fluid sampling
US5531675A (en) 1989-05-10 1996-07-02 Yoo; Tae W. Micro-acupuncture needle for a finger of a hand
CA2016900A1 (en) 1989-07-06 1991-01-06 Ronald J. Filipski Tines structure in clinical applicator
EP0429842B1 (en) 1989-10-27 1996-08-28 Korea Research Institute Of Chemical Technology Device for the transdermal administration of protein or peptide drug
US5215088A (en) 1989-11-07 1993-06-01 The University Of Utah Three-dimensional electrode device
US5697901A (en) 1989-12-14 1997-12-16 Elof Eriksson Gene delivery by microneedle injection
US5162043A (en) * 1990-03-30 1992-11-10 Alza Corporation Iontophoretic delivery device
US5279544A (en) 1990-12-13 1994-01-18 Sil Medics Ltd. Transdermal or interdermal drug delivery devices
US5527288A (en) 1990-12-13 1996-06-18 Elan Medical Technologies Limited Intradermal drug delivery device and method for intradermal delivery of drugs
TW279133B (en) 1990-12-13 1996-06-21 Elan Med Tech
US5156591A (en) 1990-12-13 1992-10-20 S. I. Scientific Innovations Ltd. Skin electrode construction and transdermal drug delivery device utilizing same
US5158073A (en) 1990-12-18 1992-10-27 Bukowski Voytek Z Acupressure foot massage mat
US5312456A (en) * 1991-01-31 1994-05-17 Carnegie Mellon University Micromechanical barb and method for making the same
US5256360A (en) 1992-03-25 1993-10-26 Panasonic Technologies, Inc. Method of manufacturing a precision micro-filter
US5318557A (en) 1992-07-13 1994-06-07 Elan Medical Technologies Limited Medication administering device
IE930532A1 (en) 1993-07-19 1995-01-25 Elan Med Tech Liquid material dispenser and valve
US5250067A (en) 1992-11-30 1993-10-05 Ala Gelfer Body treatment pad having a multiple number of sharpened skin-penetration protuberances
US5383512A (en) 1993-01-27 1995-01-24 Midwest Research Institute Method for fabricating a substrate having spaced apart microcapillaries thereon
IE68890B1 (en) 1993-04-08 1996-07-24 Elan Med Tech Intradermal delivery device
US5728089A (en) 1993-06-04 1998-03-17 The Regents Of The University Of California Microfabricated structure to be used in surgery
US5320600A (en) 1993-06-14 1994-06-14 Lambert Wm S Plural content container for simultaneous ejection
CA2132277C (en) 1993-10-22 2005-05-10 Giorgio Cirelli Injection device
CA2149836C (en) 1994-05-23 1999-07-06 Sang Bae Choi Perforating device for dermal administration
US5611806A (en) 1994-05-23 1997-03-18 Samsung Electro-Mechanics Co., Ltd. Skin perforating device for transdermal medication
KR0134151B1 (en) 1994-05-23 1998-04-14 이형도 Insulin patch
US5512219A (en) 1994-06-03 1996-04-30 Reflexite Corporation Method of casting a microstructure sheet having an array of prism elements using a reusable polycarbonate mold
US5591139A (en) 1994-06-06 1997-01-07 The Regents Of The University Of California IC-processed microneedles
US5487726A (en) 1994-06-16 1996-01-30 Ryder International Corporation Vaccine applicator system
US5771890A (en) 1994-06-24 1998-06-30 Cygnus, Inc. Device and method for sampling of substances using alternating polarity
US5498235A (en) 1994-09-30 1996-03-12 Becton Dickinson And Company Iontophoresis assembly including patch/controller attachment
US5551953A (en) 1994-10-31 1996-09-03 Alza Corporation Electrotransport system with remote telemetry link
IE72524B1 (en) 1994-11-04 1997-04-23 Elan Med Tech Analyte-controlled liquid delivery device and analyte monitor
US6120488A (en) 1994-11-28 2000-09-19 The Procter & Gamble Company Absorbent articles having cuffs and topsheet with skin care composition(s) disposed thereon
WO1996017648A1 (en) 1994-12-09 1996-06-13 Novartis Ag Transdermal system
AU5740496A (en) 1995-05-22 1996-12-11 General Hospital Corporation, The Micromechanical device and method for enhancing delivery of compounds through the skin
WO1996037256A1 (en) 1995-05-22 1996-11-28 Silicon Microdevices, Inc. Micromechanical patch for enhancing the delivery of compounds through the skin
DE19525607A1 (en) 1995-07-14 1997-01-16 Boehringer Ingelheim Kg Transcorneal drug delivery system
JP2713255B2 (en) 1995-08-11 1998-02-16 日本電気株式会社 Leachate suction device
IE77523B1 (en) 1995-09-11 1997-12-17 Elan Med Tech Medicament delivery device
US5735273A (en) 1995-09-12 1998-04-07 Cygnus, Inc. Chemical signal-impermeable mask
US5645977A (en) 1995-09-22 1997-07-08 Industrial Technology Research Institute Method of making molds for manufacturing multiple-lead microstructures
US5658515A (en) 1995-09-25 1997-08-19 Lee; Abraham P. Polymer micromold and fabrication process
JPH09215755A (en) * 1996-02-09 1997-08-19 Poritoronikusu:Kk Skin contact treating implement
US5948488A (en) 1996-04-30 1999-09-07 3M Innovative Properties Company Glittering cube-corner article
ATE234129T1 (en) 1996-06-18 2003-03-15 Alza Corp DEVICE FOR IMPROVING TRANSDERMAL ADMINISTRATION OF MEDICATIONS OR EXTRACTION OF BODY FLUID
DE19624578A1 (en) 1996-06-20 1998-01-08 Nancy L Divers Skin care device
US6183434B1 (en) 1996-07-03 2001-02-06 Spectrx, Inc. Multiple mechanical microporation of skin or mucosa
ATE231015T1 (en) 1996-09-17 2003-02-15 Deka Products Lp SYSTEM FOR DELIVERY OF MEDICATION THROUGH TRANSPORT
US5873849A (en) 1997-04-24 1999-02-23 Ichor Medical Systems, Inc. Electrodes and electrode arrays for generating electroporation inducing electrical fields
US5904712A (en) * 1997-06-12 1999-05-18 Axelgaard Manufacturing Co., Ltd. Current-controlling electrode
US5928207A (en) 1997-06-30 1999-07-27 The Regents Of The University Of California Microneedle with isotropically etched tip, and method of fabricating such a device
US6055453A (en) 1997-08-01 2000-04-25 Genetronics, Inc. Apparatus for addressing needle array electrodes for electroporation therapy
US6216034B1 (en) 1997-08-01 2001-04-10 Genetronics, Inc. Method of programming an array of needle electrodes for electroporation therapy of tissue
US6241701B1 (en) * 1997-08-01 2001-06-05 Genetronics, Inc. Apparatus for electroporation mediated delivery of drugs and genes
US6047208A (en) * 1997-08-27 2000-04-04 Becton, Dickinson And Company Iontophoretic controller
US20010023324A1 (en) 1997-11-03 2001-09-20 Allan Pronovost Glucose detector and method for diagnosing diabetes
US5938684A (en) 1997-12-09 1999-08-17 Sierra Self Healing Products, Inc. Accupressure device for therapeutic relief
PT1037687E (en) 1997-12-11 2008-12-17 Alza Corp Device for enhancing transdermal agent flux
ATE221400T1 (en) 1997-12-11 2002-08-15 Alza Corp DEVICE FOR INCREASE THE TRANSDERMAL FLOW OF ACTIVE INGREDIENTS
DK1037686T3 (en) 1997-12-11 2006-01-02 Alza Corp Apparatus for enhancing transdermal flow of agents
US6135990A (en) 1997-12-17 2000-10-24 University Of South Florida Electroporation device and method
US6778853B1 (en) * 1997-12-17 2004-08-17 University Of South Florida Electroporation device
US6106751A (en) 1998-03-18 2000-08-22 The Regents Of The University Of California Method for fabricating needles via conformal deposition in two-piece molds
US6091975A (en) 1998-04-01 2000-07-18 Alza Corporation Minimally invasive detecting device
AU767122B2 (en) * 1998-06-10 2003-10-30 Georgia Tech Research Corporation Microneedle devices and methods of manufacture and use thereof
US6503231B1 (en) * 1998-06-10 2003-01-07 Georgia Tech Research Corporation Microneedle device for transport of molecules across tissue
US6532386B2 (en) 1998-08-31 2003-03-11 Johnson & Johnson Consumer Companies, Inc. Electrotransort device comprising blades
US6036659A (en) 1998-10-09 2000-03-14 Flexsite Diagnostics, Inc. Collection device for biological samples and methods of use
US6038465A (en) 1998-10-13 2000-03-14 Agilent Technologies, Inc. Telemedicine patient platform
US6611706B2 (en) 1998-11-09 2003-08-26 Transpharma Ltd. Monopolar and bipolar current application for transdermal drug delivery and analyte extraction
US6689103B1 (en) * 1999-05-07 2004-02-10 Scimed Life System, Inc. Injection array apparatus and method
US6611707B1 (en) 1999-06-04 2003-08-26 Georgia Tech Research Corporation Microneedle drug delivery device
US6743211B1 (en) * 1999-11-23 2004-06-01 Georgia Tech Research Corporation Devices and methods for enhanced microneedle penetration of biological barriers
US6312612B1 (en) 1999-06-09 2001-11-06 The Procter & Gamble Company Apparatus and method for manufacturing an intracutaneous microneedle array
US6256533B1 (en) 1999-06-09 2001-07-03 The Procter & Gamble Company Apparatus and method for using an intracutaneous microneedle array
US6379324B1 (en) * 1999-06-09 2002-04-30 The Procter & Gamble Company Intracutaneous microneedle array apparatus
US6623457B1 (en) * 1999-09-22 2003-09-23 Becton, Dickinson And Company Method and apparatus for the transdermal administration of a substance
US6835184B1 (en) 1999-09-24 2004-12-28 Becton, Dickinson And Company Method and device for abrading skin
US6355054B1 (en) 1999-11-05 2002-03-12 Ceramoptec Industries, Inc. Laser system for improved transbarrier therapeutic radiation delivery
DE60022540T2 (en) * 1999-11-15 2006-06-14 Velcro Ind FASTENING ELEMENT FOR THE SKIN
US6511463B1 (en) 1999-11-18 2003-01-28 Jds Uniphase Corporation Methods of fabricating microneedle arrays using sacrificial molds
DE60024312T2 (en) * 1999-12-10 2006-08-17 Alza Corp., Mountain View Transdermal drug delivery of macromolecular agents and device therefor
ES2238333T3 (en) * 1999-12-10 2005-09-01 Alza Corporation DERMAL TREATMENT DEVICE FOR THE PROLONGED ADMINISTRATION OF PHARMACOS VIA TRANSDERMICA.
EP1239775B1 (en) 1999-12-16 2005-03-16 ALZA Corporation Device for enhancing transdermal flux of sampled agents
US6375627B1 (en) 2000-03-02 2002-04-23 Agilent Technologies, Inc. Physiological fluid extraction with rapid analysis
US6629949B1 (en) * 2000-05-08 2003-10-07 Sterling Medivations, Inc. Micro infusion drug delivery device
US6565532B1 (en) 2000-07-12 2003-05-20 The Procter & Gamble Company Microneedle apparatus used for marking skin and for dispensing semi-permanent subcutaneous makeup
US6494830B1 (en) 2000-06-22 2002-12-17 Guidance Interactive Technologies, Inc. Handheld controller for monitoring/using medical parameters
US6603987B2 (en) 2000-07-11 2003-08-05 Bayer Corporation Hollow microneedle patch
US6440096B1 (en) 2000-07-14 2002-08-27 Becton, Dickinson And Co. Microdevice and method of manufacturing a microdevice
US7131987B2 (en) 2000-10-16 2006-11-07 Corium International, Inc. Microstructures and method for treating and conditioning skin which cause less irritation during exfoliation
US7108681B2 (en) 2000-10-16 2006-09-19 Corium International, Inc. Microstructures for delivering a composition cutaneously to skin
US6533884B1 (en) 2000-11-03 2003-03-18 Printpack Illinois, Inc. Method and system for extrusion embossing
US6663820B2 (en) 2001-03-14 2003-12-16 The Procter & Gamble Company Method of manufacturing microneedle structures using soft lithography and photolithography
US6591124B2 (en) 2001-05-11 2003-07-08 The Procter & Gamble Company Portable interstitial fluid monitoring system

Cited By (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10238848B2 (en) 2007-04-16 2019-03-26 Corium International, Inc. Solvent-cast microprotrusion arrays containing active ingredient
US11419816B2 (en) 2010-05-04 2022-08-23 Corium, Inc. Method and device for transdermal delivery of parathyroid hormone using a microprojection array
US9687641B2 (en) 2010-05-04 2017-06-27 Corium International, Inc. Method and device for transdermal delivery of parathyroid hormone using a microprojection array
US11052231B2 (en) 2012-12-21 2021-07-06 Corium, Inc. Microarray for delivery of therapeutic agent and methods of use
US10245422B2 (en) 2013-03-12 2019-04-02 Corium International, Inc. Microprojection applicators and methods of use
US11110259B2 (en) 2013-03-12 2021-09-07 Corium, Inc. Microprojection applicators and methods of use
US10384045B2 (en) 2013-03-15 2019-08-20 Corium, Inc. Microarray with polymer-free microstructures, methods of making, and methods of use
US10384046B2 (en) 2013-03-15 2019-08-20 Corium, Inc. Microarray for delivery of therapeutic agent and methods of use
US10195409B2 (en) 2013-03-15 2019-02-05 Corium International, Inc. Multiple impact microprojection applicators and methods of use
US9962534B2 (en) 2013-03-15 2018-05-08 Corium International, Inc. Microarray for delivery of therapeutic agent, methods of use, and methods of making
US11565097B2 (en) 2013-03-15 2023-01-31 Corium Pharma Solutions, Inc. Microarray for delivery of therapeutic agent and methods of use
US10624843B2 (en) 2014-09-04 2020-04-21 Corium, Inc. Microstructure array, methods of making, and methods of use
US10857093B2 (en) 2015-06-29 2020-12-08 Corium, Inc. Microarray for delivery of therapeutic agent, methods of use, and methods of making

Also Published As

Publication number Publication date
EP1183065B1 (en) 2016-03-23
US7416541B2 (en) 2008-08-26
US6256533B1 (en) 2001-07-03
EP1183065A1 (en) 2002-03-06
US6931277B1 (en) 2005-08-16
TW458791B (en) 2001-10-11
AU5728000A (en) 2000-12-28
JP2003501162A (en) 2003-01-14
CA2376285C (en) 2006-05-09
US20050209565A1 (en) 2005-09-22
WO2000074765A1 (en) 2000-12-14

Similar Documents

Publication Publication Date Title
CA2376285A1 (en) Intracutaneous microneedle array apparatus
JP3109470B2 (en) Stratum corneum puncture needle and stratum corneum puncture member
JP4772263B2 (en) Cap for lancing device
US10625029B2 (en) Needle system
WO2002085447A8 (en) Microprojection array having a beneficial agent containing coating
AU2001266766A1 (en) Cap for a lancing device
CN105722461B (en) Blood-taking device
WO2002100253A3 (en) Blood sampling device with diaphragm actuated lancet
WO2002030488A3 (en) Device and method for obtaining interstitial fluid from a patient for diagnostic tests
WO2005051455A3 (en) Ultrasound assisted transdermal vaccine delivery method and system
EP1266607A3 (en) Percutaneous biological fluid constituent sampling and measurement devices and methods
WO2005002442A3 (en) Lancing device
PT1239775E (en) DEVICE FOR INCREASING TRANSDERMAL FLOW OF AGENT SAMPLES
WO2002047759A3 (en) Seal for use with medical device and system
WO2001028423A3 (en) Lancing device and method of sample collection
EP2609947A3 (en) Patch-like infusion device
WO2002100476A3 (en) Device for manipulating a needle or abrader array
CN208677403U (en) A kind of blood glucose sensor implanting device
JP2003534881A (en) Method and apparatus for enhancing penetration of a piercing member into an intradermal space
CA2245710A1 (en) Enhanced transdermal transport of fluid using vacuum
ES2274050T3 (en) EXTRACTION DEVICE BY PRESSING BODY LIQUIDS FROM AN INCISION.
DE60111255D1 (en) SYSTEM FOR PHYSIOLOGICAL DRAINAGE
WO2002058556A8 (en) Method and apparatus for micro-sampling
CN114632260B (en) Disposable microneedle set
EP1752189A3 (en) Microprojection array having a beneficial agent containing coating

Legal Events

Date Code Title Description
EEER Examination request
MKLA Lapsed

Effective date: 20190607