CA2373351A1 - Ion mobility and mass spectrometer - Google Patents

Ion mobility and mass spectrometer Download PDF

Info

Publication number
CA2373351A1
CA2373351A1 CA002373351A CA2373351A CA2373351A1 CA 2373351 A1 CA2373351 A1 CA 2373351A1 CA 002373351 A CA002373351 A CA 002373351A CA 2373351 A CA2373351 A CA 2373351A CA 2373351 A1 CA2373351 A1 CA 2373351A1
Authority
CA
Canada
Prior art keywords
ion
coupled
ions
instrument
spectrum
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA002373351A
Other languages
French (fr)
Other versions
CA2373351C (en
Inventor
David E. Clemmer
James P. Reilly
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Indiana University Research and Technology Corp
Original Assignee
David E. Clemmer
James P. Reilly
Advanced Research And Technology Institute, Inc.
Indiana University Research And Technology Corporation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by David E. Clemmer, James P. Reilly, Advanced Research And Technology Institute, Inc., Indiana University Research And Technology Corporation filed Critical David E. Clemmer
Publication of CA2373351A1 publication Critical patent/CA2373351A1/en
Application granted granted Critical
Publication of CA2373351C publication Critical patent/CA2373351C/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
    • H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
    • H01J49/00—Particle spectrometers or separator tubes
    • H01J49/004—Combinations of spectrometers, tandem spectrometers, e.g. MS/MS, MSn
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
    • G01N27/62—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating the ionisation of gases, e.g. aerosols; by investigating electric discharges, e.g. emission of cathode
    • G01N27/622—Ion mobility spectrometry
    • G01N27/623—Ion mobility spectrometry combined with mass spectrometry
    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
    • H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
    • H01J49/00—Particle spectrometers or separator tubes
    • H01J49/26—Mass spectrometers or separator tubes
    • H01J49/34—Dynamic spectrometers
    • H01J49/40—Time-of-flight spectrometers
    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
    • H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
    • H01J49/00—Particle spectrometers or separator tubes
    • H01J49/26—Mass spectrometers or separator tubes
    • H01J49/34—Dynamic spectrometers
    • H01J49/42—Stability-of-path spectrometers, e.g. monopole, quadrupole, multipole, farvitrons

Abstract

The instrument (300) includes an ion source region (32) coupled to an IMS (34) having is coupled to a quadrupole mass filter (302). The filter is coupled to a collision cell (304) which is coupled to an ion acceleration region of a mass spectrometer (36) such as a TOFMS. The instrument (300) is sequencing analysis wherein a three-dimensional ion spectrum (ion intensity vs. ion mobility and ion mass) is observed. If the spectrum reveals that no ions overlap in mobility values, the instrument (300) is reactivated whereby a complete three-dimensional spectrum of parent and daughter ions results. If, however, the original spectrum reveals that two or more ions overlap the QMF (302) is controlled to selectively filter out all but one of the overlapping ions.
CA002373351A 1999-05-17 2000-05-16 Ion mobility and mass spectrometer Expired - Lifetime CA2373351C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US09/313,492 US6323482B1 (en) 1997-06-02 1999-05-17 Ion mobility and mass spectrometer
US09/313,492 1999-05-17
PCT/US2000/013344 WO2000070335A2 (en) 1999-05-17 2000-05-16 Ion mobility and mass spectrometer

Publications (2)

Publication Number Publication Date
CA2373351A1 true CA2373351A1 (en) 2000-11-23
CA2373351C CA2373351C (en) 2005-02-01

Family

ID=23215918

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002373351A Expired - Lifetime CA2373351C (en) 1999-05-17 2000-05-16 Ion mobility and mass spectrometer

Country Status (7)

Country Link
US (1) US6323482B1 (en)
EP (1) EP1185860A2 (en)
JP (1) JP2002544517A (en)
AU (1) AU769697B2 (en)
CA (1) CA2373351C (en)
IL (1) IL146238A0 (en)
WO (1) WO2000070335A2 (en)

Families Citing this family (119)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6498342B1 (en) * 1997-06-02 2002-12-24 Advanced Research & Technology Institute Ion separation instrument
US6960761B2 (en) * 1997-06-02 2005-11-01 Advanced Research & Technology Institute Instrument for separating ions in time as functions of preselected ion mobility and ion mass
US6504149B2 (en) 1998-08-05 2003-01-07 National Research Council Canada Apparatus and method for desolvating and focussing ions for introduction into a mass spectrometer
US6621077B1 (en) 1998-08-05 2003-09-16 National Research Council Canada Apparatus and method for atmospheric pressure-3-dimensional ion trapping
US7098449B1 (en) 1999-07-21 2006-08-29 The Charles Stark Draper Laboratory, Inc. Spectrometer chip assembly
US7057168B2 (en) * 1999-07-21 2006-06-06 Sionex Corporation Systems for differential ion mobility analysis
US7005632B2 (en) * 2002-04-12 2006-02-28 Sionex Corporation Method and apparatus for control of mobility-based ion species identification
US6815668B2 (en) * 1999-07-21 2004-11-09 The Charles Stark Draper Laboratory, Inc. Method and apparatus for chromatography-high field asymmetric waveform ion mobility spectrometry
US7157700B2 (en) * 2001-06-30 2007-01-02 Sionex Corporation System for collection of data and identification of unknown ion species in an electric field
US7129482B2 (en) * 1999-07-21 2006-10-31 Sionex Corporation Explosives detection using differential ion mobility spectrometry
US7399958B2 (en) * 1999-07-21 2008-07-15 Sionex Corporation Method and apparatus for enhanced ion mobility based sample analysis using various analyzer configurations
US7148477B2 (en) * 1999-07-21 2006-12-12 Sionex Corporation System for trajectory-based ion species identification
US6815669B1 (en) * 1999-07-21 2004-11-09 The Charles Stark Draper Laboratory, Inc. Longitudinal field driven ion mobility filter and detection system
US6806463B2 (en) 1999-07-21 2004-10-19 The Charles Stark Draper Laboratory, Inc. Micromachined field asymmetric ion mobility filter and detection system
US6690004B2 (en) * 1999-07-21 2004-02-10 The Charles Stark Draper Laboratory, Inc. Method and apparatus for electrospray-augmented high field asymmetric ion mobility spectrometry
EP1212778A2 (en) * 1999-08-26 2002-06-12 University Of New Hampshire Multiple stage mass spectrometer
US7164122B2 (en) * 2000-02-29 2007-01-16 Ionwerks, Inc. Ion mobility spectrometer
AU2001243328A1 (en) * 2000-02-29 2001-09-12 The Texas A And M University System A periodic field focusing ion mobility spectrometer
EP1273029B8 (en) * 2000-03-14 2006-01-11 National Research Council Canada Faims apparatus and method with laser-based ionization source
EP1266209A2 (en) * 2000-03-14 2002-12-18 National Research Council of Canada Tandem high field asymmetric waveform ion mobility spectrometry (faims)/ion mobility spectrometry
US6545268B1 (en) * 2000-04-10 2003-04-08 Perseptive Biosystems Preparation of ion pulse for time-of-flight and for tandem time-of-flight mass analysis
US6639214B1 (en) * 2000-05-09 2003-10-28 Air Products And Chemicals, Inc. Method of improving the performance of an ion mobility spectrometer used to detect trace atmospheric impurities in gases
US6586727B2 (en) * 2000-06-09 2003-07-01 Micromass Limited Methods and apparatus for mass spectrometry
CA2340150C (en) * 2000-06-09 2005-11-22 Micromass Limited Methods and apparatus for mass spectrometry
CA2364676C (en) * 2000-12-08 2010-07-27 Mds Inc., Doing Business As Mds Sciex Ion mobility spectrometer incorporating an ion guide in combination with an ms device
US20020115056A1 (en) * 2000-12-26 2002-08-22 Goodlett David R. Rapid and quantitative proteome analysis and related methods
US6586732B2 (en) * 2001-02-20 2003-07-01 Brigham Young University Atmospheric pressure ionization ion mobility spectrometry
ATE504077T1 (en) 2001-05-25 2011-04-15 Ionwerks Inc TIME OF FLIGHT MASS SPECTROMETER FOR MONITORING FAST PROCESSES
US7586088B2 (en) 2001-06-21 2009-09-08 Micromass Uk Limited Mass spectrometer and method of mass spectrometry
CA2391060C (en) * 2001-06-21 2011-08-09 Micromass Limited Mass spectrometer
US6642526B2 (en) * 2001-06-25 2003-11-04 Ionfinity Llc Field ionizing elements and applications thereof
WO2003005016A1 (en) * 2001-06-30 2003-01-16 Sionex Corporation System for collection of data and identification of unknown ion species in an electric field
US7714284B2 (en) 2001-06-30 2010-05-11 Sionex Corporation Methods and apparatus for enhanced sample identification based on combined analytical techniques
US7119328B2 (en) * 2001-06-30 2006-10-10 Sionex Corporation System for DMS peak resolution
US7091481B2 (en) * 2001-08-08 2006-08-15 Sionex Corporation Method and apparatus for plasma generation
US7274015B2 (en) * 2001-08-08 2007-09-25 Sionex Corporation Capacitive discharge plasma ion source
US6727496B2 (en) * 2001-08-14 2004-04-27 Sionex Corporation Pancake spectrometer
EP1448769A4 (en) * 2001-10-31 2006-02-01 Ionfinity Llc Soft ionization device and applications thereof
GB2385918B (en) * 2001-12-08 2004-05-26 Micromass Ltd Method of mass spectrometry
US7122794B1 (en) 2002-02-21 2006-10-17 Sionex Corporation Systems and methods for ion mobility control
GB2389704B (en) * 2002-05-17 2004-06-02 * Micromass Limited Mass Spectrometer
US6906319B2 (en) * 2002-05-17 2005-06-14 Micromass Uk Limited Mass spectrometer
GB2390478B (en) * 2002-05-17 2004-06-02 Micromass Ltd Mass spectrometer
WO2003102534A2 (en) * 2002-05-30 2003-12-11 Massachusetts Institute Of Technology Chemical sampler and method
WO2003104763A2 (en) * 2002-06-05 2003-12-18 Advanced Research And Technology Institute, Inc. Apparatus and method for relative or quantitative comparison of multiple samples
US6791078B2 (en) * 2002-06-27 2004-09-14 Micromass Uk Limited Mass spectrometer
GB2392304B (en) * 2002-06-27 2004-12-15 Micromass Ltd Mass spectrometer
GB2392306B (en) * 2002-06-27 2004-08-18 Micromass Ltd Mass spectrometer
GB2390935A (en) * 2002-07-16 2004-01-21 Anatoli Nicolai Verentchikov Time-nested mass analysis using a TOF-TOF tandem mass spectrometer
US7196324B2 (en) 2002-07-16 2007-03-27 Leco Corporation Tandem time of flight mass spectrometer and method of use
GB0305796D0 (en) 2002-07-24 2003-04-16 Micromass Ltd Method of mass spectrometry and a mass spectrometer
US7071467B2 (en) * 2002-08-05 2006-07-04 Micromass Uk Limited Mass spectrometer
US7019291B2 (en) * 2002-10-12 2006-03-28 Sionex Corporation NOx monitor using differential mobility spectrometry
CN1833300B (en) 2003-03-19 2010-05-12 萨默费尼根有限公司 Tandem mass spectrometry data for obtaining multiple parent ions in an ion population
CA2472492A1 (en) * 2003-06-27 2004-12-27 Ionalytics Corporation Method of separating ions
CA2539484A1 (en) * 2003-09-17 2005-03-31 Sionex Corporation Solid-state flow generator and related systems, applications, and methods
WO2005050159A2 (en) 2003-10-14 2005-06-02 Washington State University Research Foundation Ion mobility spectrometry method and apparatus
US7618806B2 (en) * 2003-11-14 2009-11-17 Indiana University Research And Technology Corporation Methods and apparatus for mass spectral analysis of peptides and proteins
EP1690074A2 (en) * 2003-11-25 2006-08-16 Sionex Corporation Mobility based apparatus and methods using dispersion characteristics, sample fragmentation, and/or pressure control to improve analysis of a sample
EP1697024B1 (en) * 2003-12-18 2017-08-30 DH Technologies Development Pte. Ltd. Methods and apparatus for enhanced ion based sample detection using selective pre-separation and amplification
US7456394B2 (en) * 2004-02-02 2008-11-25 Sionex Corporation Compact sample analysis systems and related methods of using combined chromatography and mobility spectrometry techniques
EP1756561A1 (en) * 2004-04-28 2007-02-28 Sionex Corporation System and method for ion species analysis with enhanced condition control and data interpretation using differential mobility spectrometers
US20050253059A1 (en) * 2004-05-13 2005-11-17 Goeringer Douglas E Tandem-in-time and-in-space mass spectrometer and associated method for tandem mass spectrometry
US20050269508A1 (en) * 2004-06-03 2005-12-08 Lippa Timothy P Apparatus and methods for detecting compounds using mass spectra
JP2006032109A (en) * 2004-07-15 2006-02-02 Jeol Ltd Orthogonal acceleration time-of-flight mass spectroscope
GB0420408D0 (en) * 2004-09-14 2004-10-20 Micromass Ltd Mass spectrometer
JP4513488B2 (en) * 2004-10-06 2010-07-28 株式会社日立製作所 Ion mobility analyzer and ion mobility analysis method
GB0424426D0 (en) 2004-11-04 2004-12-08 Micromass Ltd Mass spectrometer
WO2006060807A1 (en) * 2004-12-03 2006-06-08 Sionex Corporation Method and apparatus for enhanced ion based sample filtering and detection
US7399957B2 (en) * 2005-01-14 2008-07-15 Duke University Coded mass spectroscopy methods, devices, systems and computer program products
US7148474B2 (en) * 2005-04-11 2006-12-12 Battelle Memorial Institute Device for two-dimensional gas-phase separation and characterization of ion mixtures
GB0508239D0 (en) 2005-04-23 2005-06-01 Smiths Group Plc Detection apparatus
WO2006119167A1 (en) * 2005-04-29 2006-11-09 Sionex Corporation Compact gas chromatography and ion mobility based sample analysis systems, methods, and devices
EP1894224A4 (en) 2005-05-27 2011-08-03 Ionwerks Inc Multi-beam ion mobility time-of-flight mass spectrometer with bipolar ion extraction and zwitterion detection
US7838820B2 (en) * 2005-06-06 2010-11-23 UT-Battlelle, LLC Controlled kinetic energy ion source for miniature ion trap and related spectroscopy system and method
GB2441943A (en) 2005-07-26 2008-03-19 Sionex Corp Ultra compact ion mobility based analyzer system and method
GB2432712B (en) * 2005-11-23 2007-12-27 Micromass Ltd Mass spectrometer
US20070114382A1 (en) * 2005-11-23 2007-05-24 Clemmer David E Ion mobility spectrometer
GB0523811D0 (en) * 2005-11-23 2006-01-04 Micromass Ltd Mass stectrometer
EP1955077B1 (en) 2005-12-02 2012-06-13 Sirtris Pharmaceuticals, Inc. Mass spectrometry assays for acetyltransferase/deacetylase activity
US10276358B2 (en) * 2006-01-02 2019-04-30 Excellims Corporation Chemically modified ion mobility separation apparatus and method
WO2007120373A2 (en) * 2006-01-26 2007-10-25 Sionex Corporation Differential mobility spectrometer analyzer and pre-filter apparatus, methods and systems
CN101384339B (en) * 2006-02-14 2012-07-18 卓漂仪谱公司 Ion mobility spectrometer apparatus and methods
GB0609253D0 (en) * 2006-05-10 2006-06-21 Micromass Ltd Mass spectrometer
WO2007140401A2 (en) * 2006-05-30 2007-12-06 Indiana University Research And Technology Corporation Method of operating an analyte separation instrument
US7598488B2 (en) 2006-09-20 2009-10-06 Park Melvin A Apparatus and method for field asymmetric ion mobility spectrometry combined with mass spectrometry
WO2008094704A2 (en) 2007-02-01 2008-08-07 Sionex Corporation Differential mobility spectrometer pre-filter assembly for a mass spectrometer
DE102007017055B4 (en) * 2007-04-11 2011-06-22 Bruker Daltonik GmbH, 28359 Measuring the mobility of mass-selected ions
US8334506B2 (en) 2007-12-10 2012-12-18 1St Detect Corporation End cap voltage control of ion traps
CN101470101B (en) * 2007-12-28 2011-12-21 中国航天科技集团公司第五研究院第五一〇研究所 Relative sensitivity calibration system for quadrupole mass spectrometer
US8067731B2 (en) * 2008-03-08 2011-11-29 Scott Technologies, Inc. Chemical detection method and system
US7973277B2 (en) 2008-05-27 2011-07-05 1St Detect Corporation Driving a mass spectrometer ion trap or mass filter
US8106353B2 (en) * 2009-02-13 2012-01-31 Dh Technologies Pte. Ltd. Apparatus and method of photo fragmentation
EP2419850B1 (en) * 2009-04-15 2019-03-27 Micromass UK Limited A method and system of estimating the cross-sectional area of a molecule for use in the prediction of ion mobility
WO2010124019A1 (en) * 2009-04-21 2010-10-28 Excellims Corporation Intelligently controlled spectrometer methods and apparatus
GB201101132D0 (en) * 2011-01-21 2011-03-09 Smiths Detection Watford Ltd Combination ion gate and modifier
WO2012109378A2 (en) * 2011-02-08 2012-08-16 Indiana University Research And Technology Corporation Ion mobility spectrometry and the use of the sequential elimination technique
GB201110662D0 (en) * 2011-06-23 2011-08-10 Thermo Fisher Scient Bremen Targeted analysis for tandem mass spectrometry
GB201116065D0 (en) 2011-09-16 2011-11-02 Micromass Ltd Encoding of precursor ion beam to aid product ion assignment
CA2857931C (en) * 2011-12-05 2020-03-10 Smiths Detection Montreal Inc. Systems, devices, and methods for sample analysis using mass spectrometry
GB201122178D0 (en) 2011-12-22 2012-02-01 Thermo Fisher Scient Bremen Method of tandem mass spectrometry
GB2497948A (en) 2011-12-22 2013-07-03 Thermo Fisher Scient Bremen Collision cell for tandem mass spectrometry
US8633436B2 (en) * 2011-12-22 2014-01-21 Agilent Technologies, Inc. Data acquisition modes for ion mobility time-of-flight mass spectrometry
GB201205009D0 (en) * 2012-03-22 2012-05-09 Micromass Ltd Multi-dimensional survey scans for improved data dependent acquisitions (DDA)
CN103149270B (en) * 2013-02-27 2015-07-22 上海矽感信息科技（集团）有限公司 Method for detecting grease by utilizing ion mobility spectrometer
US9459194B2 (en) 2013-03-14 2016-10-04 Cardio Metrix Apparatuses, processes, and systems for measuring particle size distribution and concentration
US11049709B2 (en) * 2013-11-12 2021-06-29 Micromass Uk Limited Ion trap mass spectrometers with space charge control
WO2015179709A1 (en) 2014-05-22 2015-11-26 Benner W Henry Instruments for measuring ion size distribution and concentration
CN105987964B (en) * 2015-02-06 2018-05-15 中国科学院大连化学物理研究所 The method that liquid chromatograph mass spectrography carries out efficiently separating identification to analyte
GB201506330D0 (en) * 2015-04-14 2015-05-27 Micromass Ltd Mass determination using ion mobility measurements
CN105304457B (en) * 2015-09-25 2017-03-29 中国工程物理研究院核物理与化学研究所 A kind of orthoscopic time of-flight mass spectrometer
DE112015006840T5 (en) * 2015-10-09 2018-05-24 Hitachi High-Technologies Corporation Ion analyzer
US9741552B2 (en) * 2015-12-22 2017-08-22 Bruker Daltonics, Inc. Triple quadrupole mass spectrometry coupled to trapped ion mobility separation
US10199208B2 (en) 2016-03-03 2019-02-05 Thermo Finnigan Llc Ion beam mass pre-separator
GB2553398B (en) * 2016-06-02 2022-06-08 Bruker Daltonics Gmbh & Co Kg Analysis of isomers in TIMS-Q-q TOF mass spectrometers
CN106169411B (en) * 2016-07-13 2018-03-27 中国计量科学研究院 New type series-parallel connected mass spectrometric apparatus system and its parameter adjusting method and application method
US10128094B2 (en) 2017-03-01 2018-11-13 Thermo Finnigan Llc Optimizing quadrupole collision cell RF amplitude for tandem mass spectrometry
GB201907171D0 (en) * 2019-05-21 2019-07-03 Thermo Fisher Scient Bremen Gmbh Switchable ion guide
US20230314372A1 (en) * 2022-04-05 2023-10-05 Thermo Finnigan Llc Ion mobility enhanced qualitative and quantitative methods

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3621240A (en) 1969-05-27 1971-11-16 Franklin Gro Corp Apparatus and methods for detecting and identifying trace gases
US3812355A (en) 1971-12-09 1974-05-21 Gno F Corp Apparatus and methods for measuring ion mass as a function of mobility
US3845301A (en) 1972-05-10 1974-10-29 Franklin Gno Corp Apparatus and methods employing ion analysis apparatus with enhanced gas flow
US3902064A (en) 1974-07-12 1975-08-26 Robert A Young Ion mobility mass spectrometer
US4261698A (en) 1980-01-23 1981-04-14 International Business Machines Corporation Trace oxygen detector
JPH03503815A (en) 1987-12-24 1991-08-22 ユニサーチ　リミテッド mass spectrometer
US5070240B1 (en) 1990-08-29 1996-09-10 Univ Brigham Young Apparatus and methods for trace component analysis
US5210412A (en) 1991-01-31 1993-05-11 Wayne State University Method for analyzing an organic sample
ATE220114T1 (en) 1993-03-19 2002-07-15 Sequenom Inc DNA SEQUENCE DETERMINATION BY MASS SPECTROMETRY THROUGH THE DEGRADATION PATH WITH EXONUCLEASE
US5689111A (en) * 1995-08-10 1997-11-18 Analytica Of Branford, Inc. Ion storage time-of-flight mass spectrometer
US5504326A (en) 1994-10-24 1996-04-02 Indiana University Foundation Spatial-velocity correlation focusing in time-of-flight mass spectrometry
DE19511333C1 (en) 1995-03-28 1996-08-08 Bruker Franzen Analytik Gmbh Method and device for orthogonal injection of ions into a time-of-flight mass spectrometer
JPH095298A (en) * 1995-06-06 1997-01-10 Varian Assoc Inc Method of detecting kind of selected ion in quadrupole ion trap
US5905258A (en) * 1997-06-02 1999-05-18 Advanced Research & Techology Institute Hybrid ion mobility and mass spectrometer
GB9717926D0 (en) * 1997-08-22 1997-10-29 Micromass Ltd Methods and apparatus for tandem mass spectrometry
JP2002502086A (en) * 1998-01-23 2002-01-22 アナリティカ オブ ブランフォード インコーポレーテッド Mass spectrometry from the surface

Also Published As

Publication number Publication date
CA2373351C (en) 2005-02-01
EP1185860A2 (en) 2002-03-13
AU769697B2 (en) 2004-01-29
AU5135200A (en) 2000-12-05
WO2000070335A3 (en) 2001-07-05
JP2002544517A (en) 2002-12-24
US6323482B1 (en) 2001-11-27
IL146238A0 (en) 2002-07-25
WO2000070335A2 (en) 2000-11-23

Similar Documents

Publication Publication Date Title
CA2373351A1 (en) Ion mobility and mass spectrometer
CA2245465A1 (en) Methods and apparatus for tandem mass spectrometry
WO1999066536A3 (en) An apparatus for reduction of selected ion intensities in confined ion beams
SG158737A1 (en) Method for increasing ionization efficiency in mass spectroscopy
GB2364168B (en) Methods and apparatus for mass spectrometry
WO2004030024A3 (en) Methods and devices for laser desorption chemical ionization
GB9715258D0 (en) Introduction of ions from ion sources into mass spectrometers
WO2000017908A3 (en) Charge reduction in electrospray mass spectrometry
EP1884980B8 (en) Mass spectrometer
WO1999040610A3 (en) A tandem time-of-flight mass spectrometer with delayed extraction and method for use
EP1638133A3 (en) Methods and apparatus for mass spectrometry
AU1932095A (en) Multipole ion guide for mass spectrometry
WO2006064280A3 (en) Mass spectrometer
AU4149797A (en) Multipole ion guide ion trap mass spectrometry
CA2090217A1 (en) Method for increased resolution in tandem mass spectrometry
CA2391140A1 (en) Mass spectrometer
CA2419492A1 (en) Methods and apparatus for gel-free qualitative and quantitative proteome analysis, and uses therefore
WO2007060427A3 (en) Mass spectrometer
CA2318586A1 (en) Mass spectrometry from surfaces
DE69402569T2 (en) Ion trap mass spectrometer
WO2001023863A3 (en) Modified ion source targets for use in liquid maldi ms
CA2317663A1 (en) Method of ion fragmentation in a quadrupole ion trap
GB9613691D0 (en) Ion trap mass spectrometer with vacuum-external ion generation
CA2355552A1 (en) Mass spectrometers and methods of mass spectrometry
AU3668599A (en) Ion trap mass spectrometer with electrospray ionization

Legal Events

Date Code Title Description
EEER Examination request
MKEX Expiry

Effective date: 20200516