CA2365826A1 - Over-coated chewing gum formulations - Google Patents
Over-coated chewing gum formulations Download PDFInfo
- Publication number
- CA2365826A1 CA2365826A1 CA002365826A CA2365826A CA2365826A1 CA 2365826 A1 CA2365826 A1 CA 2365826A1 CA 002365826 A CA002365826 A CA 002365826A CA 2365826 A CA2365826 A CA 2365826A CA 2365826 A1 CA2365826 A1 CA 2365826A1
- Authority
- CA
- Canada
- Prior art keywords
- agent
- medicament
- chewing gum
- over
- gum
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 229940112822 chewing gum Drugs 0.000 title abstract 2
- 235000015218 chewing gum Nutrition 0.000 title abstract 2
- 238000009472 formulation Methods 0.000 title 1
- 239000000203 mixture Substances 0.000 title 1
- 239000003814 drug Substances 0.000 abstract 7
- 239000003795 chemical substances by application Substances 0.000 abstract 5
- 239000011248 coating agent Substances 0.000 abstract 2
- 238000000576 coating method Methods 0.000 abstract 2
- 229940079593 drug Drugs 0.000 abstract 2
- 230000009885 systemic effect Effects 0.000 abstract 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 2
- 238000010521 absorption reaction Methods 0.000 abstract 1
- 230000001055 chewing effect Effects 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 210000002200 mouth mucosa Anatomy 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
- A61K9/2086—Layered tablets, e.g. bilayer tablets; Tablets of the type inert core-active coat
- A61K9/209—Layered tablets, e.g. bilayer tablets; Tablets of the type inert core-active coat containing drug in at least two layers or in the core and in at least one outer layer
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23G—COCOA; COCOA PRODUCTS, e.g. CHOCOLATE; SUBSTITUTES FOR COCOA OR COCOA PRODUCTS; CONFECTIONERY; CHEWING GUM; ICE-CREAM; PREPARATION THEREOF
- A23G3/00—Sweetmeats; Confectionery; Marzipan; Coated or filled products
- A23G3/34—Sweetmeats, confectionery or marzipan; Processes for the preparation thereof
- A23G3/343—Products for covering, coating, finishing, decorating
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23G—COCOA; COCOA PRODUCTS, e.g. CHOCOLATE; SUBSTITUTES FOR COCOA OR COCOA PRODUCTS; CONFECTIONERY; CHEWING GUM; ICE-CREAM; PREPARATION THEREOF
- A23G4/00—Chewing gum
- A23G4/06—Chewing gum characterised by the composition containing organic or inorganic compounds
- A23G4/08—Chewing gum characterised by the composition containing organic or inorganic compounds of the chewing gum base
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23G—COCOA; COCOA PRODUCTS, e.g. CHOCOLATE; SUBSTITUTES FOR COCOA OR COCOA PRODUCTS; CONFECTIONERY; CHEWING GUM; ICE-CREAM; PREPARATION THEREOF
- A23G4/00—Chewing gum
- A23G4/18—Chewing gum characterised by shape, structure or physical form, e.g. aerated products
- A23G4/20—Composite products, e.g. centre-filled, multi-layer, laminated
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
- A61K9/0056—Mouth soluble or dispersible forms; Suckable, eatable, chewable coherent forms; Forms rapidly disintegrating in the mouth; Lozenges; Lollipops; Bite capsules; Baked products; Baits or other oral forms for animals
- A61K9/0058—Chewing gums
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A61P21/02—Muscle relaxants, e.g. for tetanus or cramps
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/02—Nutrients, e.g. vitamins, minerals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23G—COCOA; COCOA PRODUCTS, e.g. CHOCOLATE; SUBSTITUTES FOR COCOA OR COCOA PRODUCTS; CONFECTIONERY; CHEWING GUM; ICE-CREAM; PREPARATION THEREOF
- A23G2200/00—COCOA; COCOA PRODUCTS, e.g. CHOCOLATE; SUBSTITUTES FOR COCOA OR COCOA PRODUCTS; CONFECTIONERY; CHEWING GUM; ICE-CREAM; PREPARATION THEREOF containing organic compounds, e.g. synthetic flavouring agents
- A23G2200/04—COCOA; COCOA PRODUCTS, e.g. CHOCOLATE; SUBSTITUTES FOR COCOA OR COCOA PRODUCTS; CONFECTIONERY; CHEWING GUM; ICE-CREAM; PREPARATION THEREOF containing organic compounds, e.g. synthetic flavouring agents containing vitamins, antibiotics, other medicaments
Abstract
Methods and products for delivering a medicament or agent to an individual are provided. The product includes a coating having a medicament or agent. The medicament or agent is present within the coating that surrounds a gum center (the water soluble portion and a water insoluble base portion). By chewing the gum, the medicament or agent is released from the product. Continuing to chew the chewing gum creates a pressure within the buccal cavity forcing the agent or medicament directly into the systemic system of the individual through the oral mucosa contained in the buccal cavity. This greatly enhances the absorption of the drug into the systemic system as well as the bioavailability of the drug within the system.
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US28681899A | 1999-04-06 | 1999-04-06 | |
US09/510,878 | 2000-02-23 | ||
US09/286,818 | 2000-02-23 | ||
US09/510,878 US6355265B1 (en) | 1999-04-06 | 2000-02-23 | Over-coated chewing gum formulations |
PCT/US2000/008046 WO2000059543A1 (en) | 1999-04-06 | 2000-03-24 | Over-coated chewing gum formulations |
Publications (2)
Publication Number | Publication Date |
---|---|
CA2365826A1 true CA2365826A1 (en) | 2000-10-12 |
CA2365826C CA2365826C (en) | 2008-06-10 |
Family
ID=56289995
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CA002365826A Expired - Fee Related CA2365826C (en) | 1999-04-06 | 2000-03-24 | Over-coated chewing gum formulations |
Country Status (9)
Country | Link |
---|---|
US (3) | US6355265B1 (en) |
EP (1) | EP1173215A4 (en) |
JP (2) | JP2002541123A (en) |
CN (1) | CN1230202C (en) |
AU (1) | AU772870B2 (en) |
BR (1) | BR0009604A (en) |
CA (1) | CA2365826C (en) |
PL (1) | PL350656A1 (en) |
WO (1) | WO2000059543A1 (en) |
Families Citing this family (64)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6627234B1 (en) | 1998-12-15 | 2003-09-30 | Wm. Wrigley Jr. Company | Method of producing active agent coated chewing gum products |
US7163705B2 (en) * | 1998-12-15 | 2007-01-16 | Wm. Wrigley Jr. Company | Coated chewing gum product and method of making |
US6531114B1 (en) | 1999-04-06 | 2003-03-11 | Wm. Wrigley Jr. Company | Sildenafil citrate chewing gum formulations and methods of using the same |
US6436369B2 (en) * | 1998-12-17 | 2002-08-20 | Wm. Wrigley Jr. Company | Anti-plaque emulsions and products containing same |
US20020110581A1 (en) * | 1999-04-06 | 2002-08-15 | Ream Ronald L. | Over-coated product including consumable center and medicament |
US6773716B2 (en) * | 1999-04-06 | 2004-08-10 | Wm. Wrigley Jr. Company | Over-coated chewing gum formulations |
US20020159956A1 (en) * | 1999-04-06 | 2002-10-31 | Ream Ronald L. | Over-coated chewing gum formulations |
US6355265B1 (en) | 1999-04-06 | 2002-03-12 | Wm. Wrigley Jr. Company | Over-coated chewing gum formulations |
US7935362B2 (en) * | 1999-04-06 | 2011-05-03 | Wm. Wrigley Jr. Company | Over-coated product including consumable center and medicament |
US6322806B1 (en) * | 1999-04-06 | 2001-11-27 | Wm. Wrigley Jr. Company | Over-coated chewing gum formulations including tableted center |
CA2369515A1 (en) * | 1999-04-06 | 2001-03-29 | Wm. Wrigley Jr. Company | Pharmaceutical chewing gum formulations |
US6426090B1 (en) * | 1999-04-06 | 2002-07-30 | Wm. Wrigley Jr. Company | Over-coated product including tableted center and medicament |
US6569472B1 (en) | 2000-09-01 | 2003-05-27 | Wm. Wrigley Jr. Company | Coated chewing gum products containing antacid and method of making |
US6645535B2 (en) | 1999-09-02 | 2003-11-11 | Wm. Wrigley Jr. Company | Method of making coated chewing gum products containing various antacids |
US6663849B1 (en) | 2000-09-01 | 2003-12-16 | Wm. Wrigley Jr. Company | Antacid chewing gum products coated with high viscosity materials |
US6541048B2 (en) | 1999-09-02 | 2003-04-01 | Wm. Wrigley Jr. Company | Coated chewing gum products containing an acid blocker and process of preparing |
JP2003512315A (en) * | 1999-10-20 | 2003-04-02 | ダブリューエム リグリー ジュニア カンパニー | Powder pharmaceutical formulation |
US7056542B1 (en) | 2000-01-27 | 2006-06-06 | Fonferra Tech Limited | Gum base |
US6572900B1 (en) | 2000-06-09 | 2003-06-03 | Wm. Wrigley, Jr. Company | Method for making coated chewing gum products including a high-intensity sweetener |
US7115288B2 (en) * | 2000-06-09 | 2006-10-03 | Wm. Wrigley Jr. Company | Method for making coated chewing gum products with a coating including an aldehyde flavor and a dipeptide sweetener |
US6579545B2 (en) | 2000-12-22 | 2003-06-17 | Wm. Wrigley Jr. Company | Coated chewing gum products containing an antigas agent |
US6602518B2 (en) * | 2001-06-28 | 2003-08-05 | Wm. Wrigley Jr. Company | Chewable product including active ingredient |
US6613346B2 (en) * | 2001-06-28 | 2003-09-02 | Wm. Wrigley, Jr. Company | Chewable product including active ingredient |
US6558722B2 (en) * | 2001-07-18 | 2003-05-06 | Wm. Wrigley Jr. Company | Use of powdered gum in making a coating for a confection |
US6943198B2 (en) * | 2002-02-11 | 2005-09-13 | Edizone, Lc | Invert sugar bubbles |
US8394856B2 (en) * | 2002-07-02 | 2013-03-12 | Glykon Technologies Group, Llc | (-)-Hydroxycitric acid for controlling inflammation |
GB0216413D0 (en) * | 2002-07-15 | 2002-08-21 | Nestle Sa | Tabletted chewing gum sweet |
US20070048418A1 (en) * | 2002-07-23 | 2007-03-01 | Mars, Incorporated | Polyol coated food product |
US7338677B2 (en) * | 2002-08-14 | 2008-03-04 | Wm. Wrigley Jr. Company | Methods for manufacturing coated confectionary products |
US20060198924A1 (en) * | 2002-08-14 | 2006-09-07 | Joo Song | Methods for manufacturing coated confectionery products |
US7378118B2 (en) * | 2002-08-14 | 2008-05-27 | Wm. Wrigley Jr. Company | Methods for manufacturing coated confectionary products |
US20040071681A1 (en) * | 2002-10-10 | 2004-04-15 | Lydia Muller | Method and composition for reducing cravings for a craved substance |
EP3473251B1 (en) | 2002-12-20 | 2023-12-13 | NicoNovum AB | A nicotine-cellulose combination |
US20080213363A1 (en) * | 2003-01-23 | 2008-09-04 | Singh Nikhilesh N | Methods and compositions for delivering 5-HT3 antagonists across the oral mucosa |
US8524198B2 (en) * | 2003-06-20 | 2013-09-03 | Donald W. Bailey | Xylitol dental maintenance system |
US20100158820A1 (en) * | 2003-06-20 | 2010-06-24 | Bailey Donald W | Xylitol dental maintenance system |
US20050042281A1 (en) * | 2003-08-21 | 2005-02-24 | Singh Nikhilesh N. | Compositions for delivering therapeutic agents across the oral mucosa |
US20060068058A1 (en) * | 2004-09-30 | 2006-03-30 | Cadbury Adams Usa Llc | Thermally stable, high tensile strength encapsulation compositions for actives |
EP1817014B1 (en) | 2004-11-30 | 2012-08-22 | Fertin Pharma A/S | Method of providing fast relief to a user of a nicotine chewing gum |
EP1871402B1 (en) * | 2005-02-25 | 2017-07-26 | State of Israel, Ministry of Agriculture & Rural Development, Agricultural Research Organization (A.R.O.), Volcani Center | Grape cell culture for treating inflammation |
JP5225077B2 (en) * | 2005-05-23 | 2013-07-03 | クラフト・フーズ・グローバル・ブランズ・エルエルシー | Center-filled chewing gum composition |
US8497258B2 (en) | 2005-11-12 | 2013-07-30 | The Regents Of The University Of California | Viscous budesonide for the treatment of inflammatory diseases of the gastrointestinal tract |
EP1948141A1 (en) * | 2005-11-15 | 2008-07-30 | Wm. Wrigley Jr. Company | Methods of producing coated products including active agent and products regarding same |
US20070116800A1 (en) * | 2005-11-23 | 2007-05-24 | The Coca-Cola Company | Chewing Gum with High-Potency Sweetener |
US9101160B2 (en) | 2005-11-23 | 2015-08-11 | The Coca-Cola Company | Condiments with high-potency sweetener |
JP5694645B2 (en) | 2006-03-16 | 2015-04-01 | ニコノヴァム エービーNiconovum Ab | Improved snuff composition |
US8017168B2 (en) | 2006-11-02 | 2011-09-13 | The Coca-Cola Company | High-potency sweetener composition with rubisco protein, rubiscolin, rubiscolin derivatives, ace inhibitory peptides, and combinations thereof, and compositions sweetened therewith |
JP2010518845A (en) * | 2007-02-26 | 2010-06-03 | リヴォリマー リミテッド | Medicinal chewing gum |
EP2197430A2 (en) * | 2007-09-18 | 2010-06-23 | NicoNovum AB | Stable chewing gum compositions comprising maltitol and providing rapid release of nicotine |
US20090130179A1 (en) * | 2007-11-16 | 2009-05-21 | Cadbury Adams Usa Llc | Confectionery compositions including markings for delivery of actives |
US20090226542A1 (en) * | 2007-12-29 | 2009-09-10 | Cresta Andrea K | Fitness and exercise-enhancing tablet containing protein isolate |
US20090169684A1 (en) * | 2007-12-29 | 2009-07-02 | Cresta Andrea K | Fitness and exercise enhancing tablet containing protein isolate |
JP5587298B2 (en) * | 2008-05-21 | 2014-09-10 | ノバルティス アーゲー | Tabletable chewing gum containing nicotine and buffer |
US7919107B2 (en) * | 2008-07-28 | 2011-04-05 | Sudzucker Aktiengesellschaft Mannhein/Ochsenfurt | Method for treating hypersensitive teeth |
WO2010031552A1 (en) * | 2008-09-17 | 2010-03-25 | Niconovum Ab | Process for preparing snuff composition |
CA2765033C (en) * | 2009-06-12 | 2020-07-14 | Meritage Pharma, Inc. | Methods for treating gastrointestinal disorders |
WO2011082050A1 (en) * | 2009-12-30 | 2011-07-07 | Wm. Wrigley Jr. Company | Hard and crunchy confectionary coating |
US20110268809A1 (en) | 2010-04-28 | 2011-11-03 | Paul Andrew Brinkley | Nicotine-Containing Pharmaceutical Compositions |
US20110274628A1 (en) | 2010-05-07 | 2011-11-10 | Borschke August J | Nicotine-containing pharmaceutical compositions |
JP2010252816A (en) * | 2010-08-23 | 2010-11-11 | Gumlink As | Compressed chewing gum tablet |
US9907748B2 (en) | 2011-10-21 | 2018-03-06 | Niconovum Usa, Inc. | Excipients for nicotine-containing therapeutic compositions |
JP2014158484A (en) * | 2014-04-04 | 2014-09-04 | Gumlink As | Compressed chewing gum tablet |
US20170165252A1 (en) | 2015-12-10 | 2017-06-15 | Niconovum Usa Inc. | Protein-enriched therapeutic composition |
WO2019239356A1 (en) | 2018-06-15 | 2019-12-19 | R. J. Reynolds Tobacco Company | Purification of nicotine |
Family Cites Families (185)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3029189A (en) | 1962-04-10 | S-aryl-z-mno-x-qxazolibinones | ||
US1298670A (en) | 1915-06-11 | 1919-04-01 | Stuart W Cramer | Chewing-gum. |
US1629461A (en) | 1926-04-22 | 1927-05-17 | Health Products Corp | Chewing gum |
US2892753A (en) | 1957-02-26 | 1959-06-30 | Boehringer Sohn Ingelheim | Central nervous system stimulant |
NL121097C (en) | 1958-04-18 | |||
US3011949A (en) | 1958-06-10 | 1961-12-05 | Anthony G Bilotti | Method of promoting release of active ingredients from slab chewing gum and product |
US3047461A (en) | 1960-06-10 | 1962-07-31 | American Cyanamid Co | Central nervous system stimulant |
US3075884A (en) | 1961-02-13 | 1963-01-29 | American Chicle Co | Slab chewing gums containing active ingredients and method of preparing same |
US3196172A (en) | 1963-05-20 | 1965-07-20 | American Cyanamid Co | Trifluoromethylphenylalkylenediamines |
DE1216486B (en) | 1964-04-23 | 1966-05-12 | Merck Ag E | Process for the production of coated tablets |
US3308022A (en) | 1964-06-25 | 1967-03-07 | American Cyanamid Co | Novel hypotensive compositions containing 1-substituted-3-cyano guanidines |
US3498964A (en) | 1966-08-29 | 1970-03-03 | Takashi Hayashi | Peripheral vasodilator peptide obtained from the animals of the family otariidae and method of preparing the same |
US3590057A (en) | 1967-12-21 | 1971-06-29 | Sumitomo Chemical Co | (alpha-(c5-c17)alkyl)benzyl fatty acid amides as cholesterol lowering agents |
US3877468A (en) | 1970-07-22 | 1975-04-15 | Leo Ab | Chewable tobacco substitute composition |
US3901248A (en) | 1970-07-22 | 1975-08-26 | Leo Ab | Chewable smoking substitute composition |
US3845217A (en) | 1972-11-16 | 1974-10-29 | Helsingborg L Ab | Buffered smoking substitute compositions |
FR2262005B1 (en) | 1974-02-22 | 1978-01-06 | Raffinage Cie Francaise | |
US3995064A (en) | 1975-06-04 | 1976-11-30 | Life Savers, Inc. | Method and apparatus for forming chewing gum base and product |
FR2345938A1 (en) | 1976-03-05 | 1977-10-28 | Choay Patrick | Chewing gum contg. xanthine stimulants or mixts. - including plant extracts e.g. tea and coffee extracts |
US4154814A (en) | 1978-02-13 | 1979-05-15 | EPS Chewing Gum, Inc. | Therapeutic chewing gum |
US4238510A (en) | 1979-02-21 | 1980-12-09 | Life Savers, Inc. | Sugarless coating for chewing gum and confections and method |
JPS6056143B2 (en) | 1979-08-02 | 1985-12-09 | 山之内製薬株式会社 | Amidine derivatives and their production method |
US4238475A (en) | 1979-08-01 | 1980-12-09 | Life Savers Inc. | Chewing cum capable of releasing finely divided water-insoluble materials therefrom |
US4317838A (en) | 1979-09-24 | 1982-03-02 | Life Savers, Inc. | Method for applying sugarless coating to chewing gum and confections |
US4250195A (en) | 1979-09-24 | 1981-02-10 | Life Savers, Inc. | Method for applying soft flexible sugar coating to fresh chewing gum and coated chewing gum product |
US4386063A (en) | 1980-12-18 | 1983-05-31 | International Flavors & Fragrances Inc. | Flavor use of mixtures containing 1-n-butoxy-1-ethanol acetate |
US4400372A (en) | 1981-03-05 | 1983-08-23 | Indiana University Foundation | Chewing gum |
US4386106A (en) | 1981-12-01 | 1983-05-31 | Borden, Inc. | Process for preparing a time delayed release flavorant and an improved flavored chewing gum composition |
US4452821A (en) | 1981-12-18 | 1984-06-05 | Gerhard Gergely | Confectionery product, particularly chewing gum, and process for its manufacture |
WO1983002892A1 (en) | 1982-02-22 | 1983-09-01 | Talapin, Vitaly, Ivanovich | Medicinal preparation having antinicotine effect and method for obtention thereof |
DE3213284A1 (en) | 1982-04-08 | 1983-10-13 | Winfried 8451 Kümmersbruck Kruppa | ANTI-CARIES CHEWING GUM |
US4446135A (en) | 1982-06-07 | 1984-05-01 | Sterling Drug Inc. | Chewable antacid tablets |
US4512968A (en) | 1982-11-30 | 1985-04-23 | Lion Corporation | Oral compositions |
US4459311A (en) | 1983-01-03 | 1984-07-10 | Nabisco Brands, Inc. | Process for preparing gum base |
US4533556A (en) | 1983-06-14 | 1985-08-06 | Warner-Lambert Company | Kola flavored chewing gum and preparation thereof |
US4647450A (en) | 1983-07-20 | 1987-03-03 | Warner-Lambert Company | Chewing gum compositions containing magnesium trisilicate absorbates |
US4933184A (en) | 1983-12-22 | 1990-06-12 | American Home Products Corp. (Del) | Menthol enhancement of transdermal drug delivery |
US4563345A (en) | 1984-01-23 | 1986-01-07 | Arrick Robert A | Chewing gum |
US4753805A (en) * | 1984-01-31 | 1988-06-28 | Warner-Lambert Company | Tabletted chewing gum composition and method of preparation |
US4639368A (en) | 1984-08-23 | 1987-01-27 | Farmacon Research Corporation | Chewing gum containing a medicament and taste maskers |
US4971787A (en) | 1984-08-27 | 1990-11-20 | Warner-Lambert Company | Antacid chewing gum |
US4929508A (en) | 1984-10-05 | 1990-05-29 | Warner-Lambert Company | Novel drug delivery system for antitussives |
US4935242A (en) | 1984-10-05 | 1990-06-19 | Warner-Lambert Company | Novel drug delivery system for expectorants |
US4894234A (en) | 1984-10-05 | 1990-01-16 | Sharma Shri C | Novel drug delivery system for antiarrhythmics |
US4555407A (en) | 1984-12-24 | 1985-11-26 | General Foods Corporation | Continuous chewing gum method |
WO1986003967A1 (en) | 1984-12-27 | 1986-07-17 | Gerhard Gergely | Chewing gum and production method thereof |
US4695463A (en) | 1985-05-24 | 1987-09-22 | Warner-Lambert Company | Delivery system for active ingredients and preparation thereof |
IT1189727B (en) | 1985-08-30 | 1988-02-04 | Roberto Cappellari | CHEWING RUBBER WITH DIFFERENT EFFECT IN THE TASTE AND TIME |
GB8522453D0 (en) | 1985-09-11 | 1985-10-16 | Lilly Industries Ltd | Chewable capsules |
US4753800A (en) | 1985-10-04 | 1988-06-28 | Warner-Lambert Company | Medicament adsorbates and their preparation |
GB2181646B (en) | 1985-10-22 | 1989-09-20 | David Morris | Medicated chewing gum |
ZA867327B (en) | 1985-11-04 | 1987-05-27 | Warner Lambert Co | Flavored tableted chewing gum |
US4882152A (en) | 1985-12-20 | 1989-11-21 | Yang Robert K | Confectionery delivery system for laxatives, vitamins and antacids |
US4929447A (en) | 1986-01-07 | 1990-05-29 | Warner-Lambert Company | Encapsulation composition for use with chewing gum and edible products |
US4849227A (en) | 1986-03-21 | 1989-07-18 | Eurasiam Laboratories, Inc. | Pharmaceutical compositions |
US4711774A (en) | 1986-03-27 | 1987-12-08 | Warner-Lambert Company | Medicament adsorbates with complex magnesium aluminum silicate and their preparation |
US4758424A (en) | 1986-03-27 | 1988-07-19 | Warner-Lambert Company | Medicament adsorbates of decongestants with complex magnesium aluminum silicate and their preparation |
US4716033A (en) | 1986-03-27 | 1987-12-29 | Warner-Lambert Company | Medicament adsorbates with surfactant and their preparation |
US4908211A (en) | 1986-09-08 | 1990-03-13 | Paz Armando F | Chewing gum and ingredients to chemically inhibit formation of plaque and calculus |
US4867989A (en) | 1986-09-09 | 1989-09-19 | Warner-Lambert Company | Chewing gum mineral supplement |
FR2607671B1 (en) | 1986-12-04 | 1991-02-08 | Gen Foods France | PROCESS FOR THE DIRECT MANUFACTURE OF BASE GUM FOR MASTICATORY PASTE AND CHEWING GUM |
GB8630273D0 (en) | 1986-12-18 | 1987-01-28 | Til Medical Ltd | Pharmaceutical delivery systems |
US4828820A (en) | 1987-01-15 | 1989-05-09 | Warner-Lambert Company | Chewable tooth cleaning composition |
US4835162A (en) | 1987-02-12 | 1989-05-30 | Abood Leo G | Agonists and antagonists to nicotine as smoking deterents |
US5015464A (en) | 1987-03-25 | 1991-05-14 | Amway Corporation | Antiplaque chewing gum |
US4822816A (en) | 1987-04-10 | 1989-04-18 | Oxycal Laboratories, Inc. | Compositions and methods for administering vitamin C |
US5070085A (en) | 1987-04-10 | 1991-12-03 | Oxycal Laboratories, Inc. | Compositions and methods for administering therapeutically active compounds |
US4968716A (en) | 1987-04-10 | 1990-11-06 | Oxycal Laboratories, Inc. | Compositions and methods for administering therapeutically active compounds |
US4975270A (en) | 1987-04-21 | 1990-12-04 | Nabisco Brands, Inc. | Elastomer encased active ingredients |
IE59934B1 (en) | 1987-06-19 | 1994-05-04 | Elan Corp Plc | Liquid suspension for oral administration |
US4853212A (en) | 1987-07-13 | 1989-08-01 | Warner-Lambert Company | Reduced base content chewing gum compositions having anesthetic properties |
US4822597A (en) | 1987-07-13 | 1989-04-18 | Warner-Lambert Company | Anesthetic-containing chewing gum compositions |
US4832994A (en) | 1987-09-02 | 1989-05-23 | Fey Michael S | Anti-smoking oral composition |
FR2635441B1 (en) | 1988-08-18 | 1991-12-27 | Gen Foods France | HIGH POLYMER BASE GUM BASE CONCENTRATES, THEIR PREPARATION PROCESS AND THEIR USE IN THE MANUFACTURE OF CHEWING GUM |
US5013716A (en) | 1988-10-28 | 1991-05-07 | Warner-Lambert Company | Unpleasant taste masking compositions and methods for preparing same |
KR900007862A (en) | 1988-11-10 | 1990-06-02 | 정보영 | Inhibitor of Glucan Synthesis of F-1, F-2 Fractionated by Sephadex G-50 from Cacao Bean Husk Extract |
US4938963A (en) | 1988-11-22 | 1990-07-03 | Parnell Pharmaceuticals, Inc. | Method and composition for treating xerostomia |
US4963369A (en) | 1989-01-19 | 1990-10-16 | Wm. Wrigley Jr. Co. | Gum composition containing dispersed porous beads containing active chewing gum ingredients and method |
US5139787A (en) | 1989-01-19 | 1992-08-18 | Wm. Wrigley Jr. Company | Gum composition containing dispersed porous beads containing active chewing gum ingredients and method |
US5154927A (en) | 1989-01-19 | 1992-10-13 | Wm. Wrigley Jr. Company | Gum composition containing dispersed porous beads containing active chewing gum ingredients and method |
US4968511A (en) | 1989-03-10 | 1990-11-06 | Amelia Ronald P D | Composition and process for one-step chewing gum |
SE463189B (en) | 1989-03-13 | 1990-10-22 | Eston Joensson | PREPARED PROVIDED TO BE ADDED TO AMALGAM FILLINGS IN TEMPERATURE, THEREFORE, TO PREVENT OR REDUCE THE EXPOSURE OF MERCURY SILVER OR MERCURY SILVER |
US4997659A (en) | 1989-03-28 | 1991-03-05 | The Wm. Wrigley Jr. Company | Alitame stability in chewing gum by encapsulation |
US5139794A (en) | 1989-04-19 | 1992-08-18 | Wm. Wrigley Jr. Company | Use of encapsulated salts in chewing gum |
US4978537A (en) | 1989-04-19 | 1990-12-18 | Wm. Wrigley Jr. Company | Gradual release structures for chewing gum |
DK365389D0 (en) | 1989-07-24 | 1989-07-24 | Fertin Lab As | ANTIFUNGAL CHEMICAL GUM PREPARATION |
JPH0383913A (en) | 1989-08-25 | 1991-04-09 | Lotte Co Ltd | Gum for preventing pyorrhea alveolaris |
US5512306A (en) | 1992-06-19 | 1996-04-30 | Pharmica Ab | Smoking substitute |
US5045325A (en) | 1990-09-26 | 1991-09-03 | Warner-Lambert Company | Continuous production of chewing gum using corotating twin screw extruder |
US5488962A (en) | 1990-10-10 | 1996-02-06 | Perfetti, S.P.A. | Chewing gum which is a substitute for tobacco smoke |
JPH06102605B2 (en) | 1990-11-19 | 1994-12-14 | 昭和薬品化工株式会社 | Dental test agent composition |
US5126151A (en) | 1991-01-24 | 1992-06-30 | Warner-Lambert Company | Encapsulation matrix |
DE4102629A1 (en) | 1991-01-30 | 1992-08-06 | Bayer Ag | PHARMACEUTICAL RUBBER WITH ACETYL SALICYLIC ACID |
US5179122A (en) | 1991-02-11 | 1993-01-12 | Eastman Kodak Company | Nutritional supplement containing vitamin e |
US5629013A (en) | 1991-04-04 | 1997-05-13 | The Procter & Gamble Company | Chewable calcium carbonate antacid tablet compositions |
US5244670A (en) | 1991-04-04 | 1993-09-14 | The Procter & Gamble Company | Ingestible pharmaceutical compositions for treating upper gastrointestinal tract distress |
US5380535A (en) | 1991-05-28 | 1995-01-10 | Geyer; Robert P. | Chewable drug-delivery compositions and methods for preparing the same |
US5221698A (en) | 1991-06-27 | 1993-06-22 | The Regents Of The University Of Michigan | Bioactive composition |
ATE197126T1 (en) | 1991-08-26 | 2000-11-15 | Abbott Lab | COMPOUNDS AND METHODS FOR SUBLINGUAL OR BUCCAL ADMINISTRATION OF THERAPEUTIC AGENTS |
GB9127150D0 (en) | 1991-12-20 | 1992-02-19 | Smithkline Beecham Plc | Novel treatment |
US5286500A (en) | 1992-03-03 | 1994-02-15 | Wm. Wrigley Jr. Company | Wax-free chewing gum base |
US5665406A (en) | 1992-03-23 | 1997-09-09 | Wm. Wrigley Jr. Company | Polyol coated chewing gum having improved shelf life and method of making |
US5270061A (en) * | 1992-03-26 | 1993-12-14 | Wm. Wrigley Jr. Company | Dual composition hard coated gum with improved shelf life |
EP0566174B1 (en) | 1992-03-26 | 1996-06-12 | Loders Croklaan B.V. | Green chewing gum base |
US5294449A (en) | 1992-04-09 | 1994-03-15 | Wm. Wrigley Jr. Company | Composition of anti-cavity chewing gum and method of fighting tooth decay by using erythrose as anticaries agent |
US5286502A (en) | 1992-04-21 | 1994-02-15 | Wm. Wrigley Jr. Company | Use of edible film to prolong chewing gum shelf life |
US5229137A (en) | 1992-05-06 | 1993-07-20 | Brigham And Women's Hospital, Inc. | Methods and pharmaceutical compositions for treating episodic heartburn |
GB9221414D0 (en) | 1992-10-13 | 1992-11-25 | Glaxo Group Ltd | Pharmaceutical compositions |
US5380530A (en) | 1992-12-29 | 1995-01-10 | Whitehill Oral Technologies | Oral care composition coated gum |
US5496541C1 (en) | 1993-01-19 | 2001-06-26 | Squigle Inc | Tasteful toothpaste and other dental products |
US5378131A (en) | 1993-02-18 | 1995-01-03 | The Wm. Wrigley Jr. Company | Chewing gum with dental health benefits employing calcium glycerophosphate |
FR2706771A1 (en) | 1993-06-21 | 1994-12-30 | Pelletier Jacques | Formula for the treatment of certain cancers. |
US5340566A (en) | 1993-08-09 | 1994-08-23 | Colgate-Palmolive Company | Method for preventing the progression of gingivitis |
EP0785724B1 (en) * | 1993-09-15 | 2002-08-28 | Wm. Wrigley Jr. Company | Chewing gum pellet having a hard coating containing erythritol |
EP0719093B1 (en) * | 1993-09-15 | 2000-03-08 | Wm. Wrigley Jr. Company | Hard coated chewing gum with improved shelf life, with mixed polyol coatings |
US5397580A (en) | 1993-10-22 | 1995-03-14 | Wm. Wrigley Jr. Company | Continuous gum base manufacture using sequential mixers |
US5419919A (en) | 1993-10-22 | 1995-05-30 | Wm. Wrigley Jr. Company | Continuous gum base manufacture using paddle mixing |
US5543160A (en) | 1994-09-13 | 1996-08-06 | Wm. Wrigley Jr. Company | Total chewing gum manufacture using high efficiency continuous mixing |
US5494685A (en) | 1994-05-17 | 1996-02-27 | Wm. Wrigley Jr. Company | Chewing gum with a rolling compound containing erythritol |
US5916606A (en) | 1993-09-30 | 1999-06-29 | Wm. Wrigley Jr. Company | Chewing gum compositions containing erythritol and a moisture binding agent |
DE4342568A1 (en) | 1993-12-14 | 1994-06-01 | Paul Ralf Peter | Chewing gum contg. caffeine - used as substitute for coffee, tea, cola, etc. and to control fatigue and migraine |
US5580590A (en) | 1993-12-27 | 1996-12-03 | The Wm. Wrigley Jr. Company | Environmentally friendly chewing gum compositions containing elastic protein-based polymers and method of making it |
JPH07184548A (en) | 1993-12-28 | 1995-07-25 | Meiji Seito Kk | Component for oral cavity |
WO1996037182A1 (en) | 1995-05-26 | 1996-11-28 | Tom Kalili | Chewing gum with fluoride and citric acid |
US5585110A (en) | 1994-03-28 | 1996-12-17 | Kalili; Tom | Chewing gum composition with fluoride and citric acid |
US5834002A (en) | 1994-05-02 | 1998-11-10 | Josman Laboratories, Inc. | Chewing gum containing colloidal bismuth subcitrate |
US5536511A (en) | 1994-05-06 | 1996-07-16 | Wm. Wrigley Jr. Company | Chewing gum pellet coated with a hard coating containing erythritol and xylitol |
FR2719999B1 (en) | 1994-05-17 | 1996-08-02 | Georges Serge Grimberg | Pharmaceutical composition based on guar gum and a neutralizing antacid, to which can be added a series of therapeutic active ingredients. |
EP0685164A1 (en) | 1994-06-03 | 1995-12-06 | Asama Chemical Co., Ltd. | Food quality improver |
KR960006319B1 (en) | 1994-06-30 | 1996-05-13 | 이승우 | Chewing gum with pilocarpine |
US5582855A (en) | 1994-07-01 | 1996-12-10 | Fuisz Technologies Ltd. | Flash flow formed solloid delivery systems |
IT1274034B (en) | 1994-07-26 | 1997-07-14 | Applied Pharma Res | PHARMACEUTICAL COMPOSITIONS BASED ON RUBBER TO BE CHEWED AND PROCEDURE FOR THEIR PREPARATION |
US5554380A (en) | 1994-08-04 | 1996-09-10 | Kv Pharmaceutical Company | Bioadhesive pharmaceutical delivery system |
US5456677A (en) | 1994-08-22 | 1995-10-10 | Spector; John E. | Method for oral spray administration of caffeine |
US5576344A (en) | 1994-08-30 | 1996-11-19 | American Home Products Corporation | Process for reducing the adverse taste and malodor associated with H2 -antagonists |
JPH10502541A (en) | 1994-09-13 | 1998-03-10 | ダブリューエム リグリー ジュニア カンパニー | Gum base continuous production method |
WO1996015768A1 (en) | 1994-11-18 | 1996-05-30 | The Procter & Gamble Company | Oral compositions |
US5744164A (en) | 1994-12-16 | 1998-04-28 | Nestec S.A. | Sustained release microparticulate caffeine formulation |
US5534272A (en) | 1995-01-03 | 1996-07-09 | Bernstein Brothers Marketing Corp. | Appetite suppressant chewing gum containing chromic picolinate |
IL139728A (en) | 1995-01-09 | 2003-06-24 | Penwest Pharmaceuticals Compan | Aqueous slurry composition containing microcrystalline cellulose for preparing a pharmaceutical excipient |
FR2729967A1 (en) | 1995-01-30 | 1996-08-02 | Oreal | COMPOSITIONS BASED ON AN ABRASIVE SYSTEM AND A SURFACE-ACTIVE SYSTEM |
US5569477A (en) | 1995-04-28 | 1996-10-29 | Mccready Consumer Products, Inc. | Chewing gum containing vitamins or other active materials |
US5854267A (en) | 1995-06-02 | 1998-12-29 | Merck & Co., Inc. | Method for preventing heartburn |
US5607697A (en) | 1995-06-07 | 1997-03-04 | Cima Labs, Incorporated | Taste masking microparticles for oral dosage forms |
US5716928A (en) | 1995-06-07 | 1998-02-10 | Avmax, Inc. | Use of essential oils to increase bioavailability of oral pharmaceutical compounds |
US5665386A (en) | 1995-06-07 | 1997-09-09 | Avmax, Inc. | Use of essential oils to increase bioavailability of oral pharmaceutical compounds |
US5645853A (en) | 1995-08-08 | 1997-07-08 | Enamelon Inc. | Chewing gum compositions and the use thereof for remineralization of lesions in teeth |
DE19529862A1 (en) | 1995-08-14 | 1997-02-20 | Rhone Poulenc Rorer Gmbh | Pharmaceutical preparation for oral use |
US5618517A (en) | 1995-10-03 | 1997-04-08 | Church & Dwight Co., Inc. | Chewing gum product with dental care benefits |
US5702687A (en) | 1995-10-03 | 1997-12-30 | Church & Dwight Co., Inc. | Chewing gum product with plaque-inhibiting benefits |
US5693334A (en) | 1995-10-05 | 1997-12-02 | Church & Dwight Co., Inc. | Chewing gum product with dental health benefits |
EP0784933A3 (en) | 1995-10-16 | 1997-11-26 | Leaf, Inc. | Extended release of additives in comestible products |
EP0867191A4 (en) | 1995-11-27 | 2000-01-05 | Yamanouchi Pharma Co Ltd | Drug composition |
US5629035A (en) | 1995-12-18 | 1997-05-13 | Church & Dwight Co., Inc. | Chewing gum product with encapsulated bicarbonate and flavorant ingredients |
US5889028A (en) | 1996-02-09 | 1999-03-30 | Mayo Foundation For Medical Education And Research | Colonic delivery of nicotine to treat inflammatory bowel disease |
US5736175A (en) | 1996-02-28 | 1998-04-07 | Nabisco Technology Co. | Chewing gums containing plaque disrupting ingredients and method for preparing it |
US5912007A (en) | 1996-02-29 | 1999-06-15 | Warner-Lambert Company | Delivery system for the localized administration of medicaments to the upper respiratory tract and methods for preparing and using same |
US5846557A (en) | 1996-03-20 | 1998-12-08 | Cumberland Packing Corporation | Chewing gum containing cough suppressing agent |
US5866179A (en) | 1996-05-03 | 1999-02-02 | Avant-Garde Technologies & Products S.A. | Medicated chewing gum and a process for preparation thereof |
US5776956A (en) | 1996-07-30 | 1998-07-07 | Lectec Corporation | Use of cotinine in treating psychiatric disorders |
US5877173A (en) | 1996-08-28 | 1999-03-02 | Washington University | Preventing neuronal degeneration in Alzheimer's disease |
US5989588A (en) | 1996-10-04 | 1999-11-23 | Merck & Co., Inc. | Methods and compositions for preventing and treating heartburn |
US5882702A (en) | 1996-10-07 | 1999-03-16 | Warner-Lambert Company | Process for the formation of plasticized proteinaceous materials and compositions containing the same |
US5897891A (en) | 1996-11-18 | 1999-04-27 | Godfrey; John C. | Flavorful zinc compositions for oral use incorporating copper |
AU1274597A (en) * | 1996-11-27 | 1998-06-22 | Wm. Wrigley Jr. Company | Method of controlling release of caffeine in chewing gum and gum produced thereby |
US5980955A (en) | 1996-12-30 | 1999-11-09 | Wm. Wrigley Jr. Company | Coated chewing gum product and method of making |
US5753255A (en) | 1997-02-11 | 1998-05-19 | Chavkin; Leonard | Chewable molded tablet containing medicinally active substances |
US5958472A (en) | 1997-02-26 | 1999-09-28 | Warner-Lambert Company | Crunchy chewing gum and process for making |
US5824291A (en) | 1997-06-30 | 1998-10-20 | Media Group | Chewing gum containing a teeth whitening agent |
US5958380A (en) | 1997-07-07 | 1999-09-28 | Enamelon, Inc. | Chewing gum products and the use thereof for remineralizing subsurface dental lesions and for mineralizing exposed dentinal tubules |
US5858383A (en) | 1997-08-11 | 1999-01-12 | Summers Laboratories, Inc. | Methods and compositions for topical treatment of ectoparasites |
US5900230A (en) | 1997-08-18 | 1999-05-04 | Squigle, Inc. | Dental products to treat and prevent periodontal disease |
JPH1168559A (en) | 1997-08-20 | 1999-03-09 | Nec Corp | Phase-locked loop circuit |
US6221402B1 (en) | 1997-11-20 | 2001-04-24 | Pfizer Inc. | Rapidly releasing and taste-masking pharmaceutical dosage form |
US5922346A (en) | 1997-12-01 | 1999-07-13 | Thione International, Inc. | Antioxidant preparation |
US5928664A (en) | 1998-02-11 | 1999-07-27 | Fuisz Technologies Ltd. | Consumable gummy delivery system |
US6200604B1 (en) | 1998-03-27 | 2001-03-13 | Cima Labs Inc. | Sublingual buccal effervescent |
US6024988A (en) | 1998-06-01 | 2000-02-15 | Wm. Wrigley Jr. Company | Caffeine chewing gum |
US6531114B1 (en) | 1999-04-06 | 2003-03-11 | Wm. Wrigley Jr. Company | Sildenafil citrate chewing gum formulations and methods of using the same |
US6303159B2 (en) | 1998-12-30 | 2001-10-16 | Wm Wrigley Jr. Company | Comestible coating process applying powder and suspension syrup |
US6355265B1 (en) | 1999-04-06 | 2002-03-12 | Wm. Wrigley Jr. Company | Over-coated chewing gum formulations |
US6322806B1 (en) | 1999-04-06 | 2001-11-27 | Wm. Wrigley Jr. Company | Over-coated chewing gum formulations including tableted center |
US6350480B1 (en) | 1999-12-30 | 2002-02-26 | Wm. Wrigley Jr. Company | Chewing gum product including a hydrophilic gum base and method of producing |
US20020022057A1 (en) | 2000-08-17 | 2002-02-21 | Battey Alyce S. | Oral delivery of pharmaceuticals via encapsulation |
EP1217109A3 (en) | 2000-12-22 | 2003-04-02 | Maschinenfabrik Rieter Ag | Spinning device |
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2000
- 2000-02-23 US US09/510,878 patent/US6355265B1/en not_active Expired - Fee Related
- 2000-03-24 BR BR0009604-0A patent/BR0009604A/en not_active IP Right Cessation
- 2000-03-24 CN CNB008059764A patent/CN1230202C/en not_active Expired - Lifetime
- 2000-03-24 CA CA002365826A patent/CA2365826C/en not_active Expired - Fee Related
- 2000-03-24 EP EP00919679A patent/EP1173215A4/en not_active Ceased
- 2000-03-24 PL PL00350656A patent/PL350656A1/en not_active Application Discontinuation
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2007
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WO2000059543A1 (en) | 2000-10-12 |
AU4032700A (en) | 2000-10-23 |
CN1230202C (en) | 2005-12-07 |
PL350656A1 (en) | 2003-01-27 |
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AU772870B2 (en) | 2004-05-13 |
CN1346283A (en) | 2002-04-24 |
US6465003B2 (en) | 2002-10-15 |
US6355265B1 (en) | 2002-03-12 |
BR0009604A (en) | 2001-12-26 |
EP1173215A4 (en) | 2003-03-26 |
US20020039560A1 (en) | 2002-04-04 |
JP2007326876A (en) | 2007-12-20 |
EP1173215A1 (en) | 2002-01-23 |
CA2365826C (en) | 2008-06-10 |
JP2002541123A (en) | 2002-12-03 |
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