CA2362204A1 - Immunogenic complexes and methods relating thereto - Google Patents

Immunogenic complexes and methods relating thereto Download PDF

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Publication number
CA2362204A1
CA2362204A1 CA002362204A CA2362204A CA2362204A1 CA 2362204 A1 CA2362204 A1 CA 2362204A1 CA 002362204 A CA002362204 A CA 002362204A CA 2362204 A CA2362204 A CA 2362204A CA 2362204 A1 CA2362204 A1 CA 2362204A1
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CA
Canada
Prior art keywords
vaccine composition
adjuvant
immunogenic complex
composition according
antigen
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA002362204A
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French (fr)
Other versions
CA2362204C (en
Inventor
John Cooper Cox
Debbie Pauline Drane
Andreas Suhrbier
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CSL Ltd
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Individual
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Filing date
Publication date
Priority claimed from AUPP8735A external-priority patent/AUPP873599A0/en
Priority claimed from AUPQ1861A external-priority patent/AUPQ186199A0/en
Application filed by Individual filed Critical Individual
Publication of CA2362204A1 publication Critical patent/CA2362204A1/en
Application granted granted Critical
Publication of CA2362204C publication Critical patent/CA2362204C/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/39—Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A61P31/06—Antibacterial agents for tuberculosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511—Organic adjuvants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511—Organic adjuvants
    • A61K2039/55561—CpG containing adjuvants; Oligonucleotide containing adjuvants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511—Organic adjuvants
    • A61K2039/55572—Lipopolysaccharides; Lipid A; Monophosphoryl lipid A
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511—Organic adjuvants
    • A61K2039/55577—Saponins; Quil A; QS21; ISCOMS
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/57—Medicinal preparations containing antigens or antibodies characterised by the type of response, e.g. Th1, Th2

Abstract

The present invention relates generally to an immunogenic complex comprising a charged organic carrier and a charged antigen and, more particularly, a negatively charged organic carrier and a positively charged antigen. The complexes of the present invention are useful, inter alia, as therapeutic and/or prophylactic agents for facilitating the induction of a cytotoxic T- lymphocyte response to an antigen.

Claims (51)

1. An immunogenic complex comprising a charged organic carrier and a charged antigen, which organic carrier and antigen are electrostatically associated.
2. The immunogenic complex according to claim 1 wherein said carrier is negatively charged and said antigen is positively charged.
3. The immunogenic complex according to claim 2 wherein said antigen is a protein or derivative or equivalent thereof.
4. The immunogenic complex according to claim 2 wherein said carrier is an adjuvant or derivative or equivalent thereof.
5. The immunogenic complex according to claim 2 wherein said antigen is a protein or derivative or equivalent thereof and said carrier is an adjuvant or derivative or equivalent thereof.
6. The immunogenic complex according to claim 5 wherein said negatively charged adjuvant is a naturally negatively charged adjuvant which has been modified to increase the degree of its negative charge.
7. The immunogenic complex according to claim 5 wherein said positively charged protein is a naturally positively charged protein which has been modified to increase the degree of its positive charge.
8. The immunogenic complex according to claim 5 wherein said negatively charged adjuvant is a naturally negatively charged adjuvant which has been modified to increase the degree of its negative charge and said positively charged protein is a naturally positively charged protein which has been modified to increase the degree of its positive charge.
9. The immunogenic complex according to any one of claims 5-8 wherein said adjuvant comprises a saponin.
10. The immunogenic complex according to any one of claims 5-8 wherein said adjuvant is a saponin complex.
11. The immunogenic complex according to claim 10 wherein said saponin complex is ISCOMATRIXT.TM..
12. The immunogenic complex according to any one of claims 5-8 wherein said adjuvant comprises a phospholipid.
13. The immunogenic complex according to claim 12 wherein said phospholipid is a phosphoglyceride.
14. The immunogenic complex according to claim 13 wherein the phosphoglyceride is selected from the group consisting of phosphatidyl inositol, phosphatidyl glycerol, phosphatidic acid and cardiolipin.
15. The immunogenic complex according to claim 12 wherein said phospholipid is lipid A.
16. The immunogenic complex according to claim 15 wherein the lipid A is selected from the group consisting of diphosphoryl lipid A such as OM174 and monophosphoryl lipid A.
17. The immunogenic complex according to any one of claims 1-16 wherein said complex induces a cytotoxic T-lymphocyte response.
18. A vaccine composition comprising as the active component a charged organic carrier and a charged antigen, which carrier and antigen are electrostatically associated, together with one or more pharmaceutically acceptable carriers and/or diluents.
19. The vaccine composition according to claim 18 wherein said carrier is negatively charged and said antigen is positively charged.
20. The vaccine composition according to claim 19 wherein said antigen is a protein or derivative or equivalent thereof.
21. The vaccine composition according to claim 19 wherein said carrier is an adjuvant or derivative or equivalent thereof.
22. The vaccine composition according to claim 19 wherein said antigen is a protein or derivative or equivalent thereof and said carrier is an adjuvant or derivative or equivalent thereof.
23. The vaccine composition according to claim 22 wherein said negatively charged adjuvant is a naturally negatively charged adjuvant which has been modified to increase the degree of its negative charge.
24. The vaccine composition according to claim 22 wherein said positively charged protein is a naturally positively charged protein which has been modified to increase the degree of its positive charge.
25. The vaccine composition according to claim 22 wherein said negatively charged adjuvant is a naturally negatively charged adjuvant which has been modified to increase the degree of its negative charge and said positively charged protein is a naturally positively charged protein which has been modified to increase the degree of its positive charge.
26. The vaccine composition according to any one of claims 22-25 wherein said adjuvant comprises a saponin.
27. The immunogenic complex according to any one of claims 22-25 wherein said adjuvant is a saponin complex.
28. The vaccine composition according to claim 27 wherein said saponin complex is ISCOMATRIX.TM..
29. The vaccine composition according to any one of claims 22-25 wherein said adjuvant comprises a phospholipid.
30. The vaccine composition according to claim 29 wherein said phospholipid is a phosphoglyceride.
31. The vaccine composition according to claim 30 wherein the phosphoglyceride is selected from the group consisting of phosphatidyl inositol, phosphatidyl glycerol, phosphatidic acid and cardiolipin.
32. The vaccine composition according to claim 29 wherein said phospholipid is lipid A.
33. The vaccine composition according to claim 32 wherein the lipid A is selected from the group consisting of diphosphoryl lipid A such as OM174 and monophosphoryl lipid A.
34. The vaccine composition according to any one of claims 18-33 wherein said composition induces a cytotoxic T-lymphocyte response.
35. A method of eliciting, inducing or otherwise facilitating, in a mammal, an immune response to an antigen said method comprising administering to said mammal an effective amount of an immunogenic complex according to any one of claims 1-17.
36. A method of eliciting, inducing or otherwise facilitating, in a mammal, an immune response to an antigen said method comprising administering to said mammal an effective amount of a vaccine composition according to any one of claims 18-34.
37. The method according to claim 17 or 36 wherein said immune response comprises a cytotoxic T-lymphocyte response.
38. A method of treating a disease condition in a mammal said method comprising administering to said mammal an effective amount of an immunogenic complex according to any one of claims 1-17 wherein administering said complex elicits, induces or otherwise facilitates an immune response which inhibits, halts, delays or prevents the onset or progression of said disease condition.
39. A method of treating a disease condition in a mammal said method comprising administering to said mammal an effective amount of a vaccine composition according to any one of claims 18-34 wherein administering said composition elicits, induces or otherwise facilitates an immune response which inhibits, halts, delays or prevents the onset or progression of the disease condition.
40. The method according to claim 38 or 39 wherein said immune response comprises a cytotoxic T-lymphocyte response.
41. The method according to any one of claims 38-41 wherein said treatment is therapeutic or prophylactic.
42. The method according to any one of claims 38-41 wherein said disease condition results from a microbial infection or a cancer.
43. The method according to claim 43 wherein said microbial infection is HIV, Hepatitis B, Hepatitis C, tuberculosis or a parasitic condition and said cancer is melanoma, prostate cancer or breast cancer.
44. Use of an immunogenic complex according to any one of claims 1-17 in the manufacture of a medicament for inhibiting, halting, delaying or preventing the onset or progression of a disease condition.
45. Use of a vaccine composition according to any one of claims 18-34 in the manufacture of a medicament for inhibiting, halting, delaying or preventing the onset or progression of a disease condition.
46. Use according to claim 44 or 45 wherein said disease condition results from a microbial infection or a cancer.
47. Use according to claim 46 wherein said microbial infection is HIV, Hepatitis B, Hepatitis C, tuberculosis or a parasitic infection and said cancer is melanoma, prostate cancer or breast cancer.
48. An agent for use in inhibiting, halting, delaying or preventing the onset or progression of a disease condition wherein said agent comprises an immunogenic complex according to any one of claims 1-17.
49. An agent for use in inhibiting, halting, delaying or preventing the onset or progression of a disease condition wherein said agent comprises a vaccine composition according to any one of claims 18-34.
50. An agent according to claim 48 or 49 wherein said disease condition results from a microbial infection or a cancer.
51. An agent according to claim 50 wherein said microbial infection is HIV, Hepatitis B, Hepatitis C, tuberculosis or a parasitic infection and said cancer is melanoma, prostate cancer or breast cancer.
CA2362204A 1999-02-17 2000-02-17 Immunogenic complexes and methods relating thereto Expired - Lifetime CA2362204C (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
AUPP8735 1999-02-17
AUPP8735A AUPP873599A0 (en) 1999-02-17 1999-02-17 Immunogenic compositions and methods relating thereto
AUPQ1861 1999-07-27
AUPQ1861A AUPQ186199A0 (en) 1999-07-27 1999-07-27 Immunogenic complexes and methods relating thereto-ii
PCT/AU2000/000110 WO2000048630A1 (en) 1999-02-17 2000-02-17 Immunogenic complexes and methods relating thereto

Publications (2)

Publication Number Publication Date
CA2362204A1 true CA2362204A1 (en) 2000-08-24
CA2362204C CA2362204C (en) 2011-11-08

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CA2362204A Expired - Lifetime CA2362204C (en) 1999-02-17 2000-02-17 Immunogenic complexes and methods relating thereto

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US (2) US7776343B1 (en)
EP (2) EP2204186B1 (en)
JP (1) JP5084984B2 (en)
AT (1) ATE464907T1 (en)
AU (1) AU783344B2 (en)
CA (1) CA2362204C (en)
DE (1) DE60044236D1 (en)
DK (1) DK2204186T3 (en)
ES (1) ES2572834T3 (en)
HK (1) HK1039895B (en)
NZ (1) NZ513935A (en)
WO (1) WO2000048630A1 (en)

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