CA2355397C - Rendering of diagnostic imaging data on a three-dimensional map - Google Patents
Rendering of diagnostic imaging data on a three-dimensional map Download PDFInfo
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- CA2355397C CA2355397C CA2355397A CA2355397A CA2355397C CA 2355397 C CA2355397 C CA 2355397C CA 2355397 A CA2355397 A CA 2355397A CA 2355397 A CA2355397 A CA 2355397A CA 2355397 C CA2355397 C CA 2355397C
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B8/00—Diagnosis using ultrasonic, sonic or infrasonic waves
- A61B8/52—Devices using data or image processing specially adapted for diagnosis using ultrasonic, sonic or infrasonic waves
- A61B8/5269—Devices using data or image processing specially adapted for diagnosis using ultrasonic, sonic or infrasonic waves involving detection or reduction of artifacts
- A61B8/5276—Devices using data or image processing specially adapted for diagnosis using ultrasonic, sonic or infrasonic waves involving detection or reduction of artifacts due to motion
-
- G—PHYSICS
- G06—COMPUTING; CALCULATING OR COUNTING
- G06T—IMAGE DATA PROCESSING OR GENERATION, IN GENERAL
- G06T17/00—Three dimensional [3D] modelling, e.g. data description of 3D objects
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/06—Devices, other than using radiation, for detecting or locating foreign bodies ; determining position of probes within or on the body of the patient
- A61B5/061—Determining position of a probe within the body employing means separate from the probe, e.g. sensing internal probe position employing impedance electrodes on the surface of the body
- A61B5/062—Determining position of a probe within the body employing means separate from the probe, e.g. sensing internal probe position employing impedance electrodes on the surface of the body using magnetic field
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/103—Detecting, measuring or recording devices for testing the shape, pattern, colour, size or movement of the body or parts thereof, for diagnostic purposes
- A61B5/107—Measuring physical dimensions, e.g. size of the entire body or parts thereof
- A61B5/1077—Measuring of profiles
-
- G—PHYSICS
- G06—COMPUTING; CALCULATING OR COUNTING
- G06T—IMAGE DATA PROCESSING OR GENERATION, IN GENERAL
- G06T7/00—Image analysis
- G06T7/30—Determination of transform parameters for the alignment of images, i.e. image registration
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/24—Detecting, measuring or recording bioelectric or biomagnetic signals of the body or parts thereof
- A61B5/316—Modalities, i.e. specific diagnostic methods
- A61B5/318—Heart-related electrical modalities, e.g. electrocardiography [ECG]
- A61B5/346—Analysis of electrocardiograms
- A61B5/349—Detecting specific parameters of the electrocardiograph cycle
- A61B5/352—Detecting R peaks, e.g. for synchronising diagnostic apparatus; Estimating R-R interval
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/72—Signal processing specially adapted for physiological signals or for diagnostic purposes
- A61B5/7203—Signal processing specially adapted for physiological signals or for diagnostic purposes for noise prevention, reduction or removal
- A61B5/7207—Signal processing specially adapted for physiological signals or for diagnostic purposes for noise prevention, reduction or removal of noise induced by motion artifacts
- A61B5/721—Signal processing specially adapted for physiological signals or for diagnostic purposes for noise prevention, reduction or removal of noise induced by motion artifacts using a separate sensor to detect motion or using motion information derived from signals other than the physiological signal to be measured
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B6/00—Apparatus for radiation diagnosis, e.g. combined with radiation therapy equipment
- A61B6/50—Clinical applications
- A61B6/503—Clinical applications involving diagnosis of heart
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B8/00—Diagnosis using ultrasonic, sonic or infrasonic waves
- A61B8/08—Detecting organic movements or changes, e.g. tumours, cysts, swellings
- A61B8/0883—Detecting organic movements or changes, e.g. tumours, cysts, swellings for diagnosis of the heart
-
- G—PHYSICS
- G06—COMPUTING; CALCULATING OR COUNTING
- G06T—IMAGE DATA PROCESSING OR GENERATION, IN GENERAL
- G06T2207/00—Indexing scheme for image analysis or image enhancement
- G06T2207/30—Subject of image; Context of image processing
- G06T2207/30004—Biomedical image processing
- G06T2207/30048—Heart; Cardiac
Abstract
A method for mapping a structure in a body of a subject includes capturing a three- dimensional (3D) image of the structure comprising diagnostic information, and generating a 3D geometrical map of the structure using a probe inserted into the structure. The image is registered with the map, such that each of a plurality of image points in the image is identified with a corresponding map point in the map. The map is displayed such that the diagnostic information associated with each of the image points is displayed at the corresponding map point.
Description
RENDERING OF DIAGNOSTIC IMAGING DATA ON A THREE-DIMENSIONAL MAP
FIELD OF THE INVENTION
The present invention relates generally to systems and methods for three-dimensional mapping and reconstruction, and specifically to mapping and reconstruction of the interior of body organs, such as the heart.
BACKGROUND OF THE INVENTION
Various methods of diagnostic imaging are known in the art. Methods used for imaging the heart, for example, include fluoroscopy, angiography, echocardiography, computed tomography (CT), magnetic resonance imaging (MRI), positron emission tomography (PET) and single photon emission tomography (SPECT). Many of these methods produce three-dimensional (3D) image information, which can then be rendered for viewing in the form of parallel slices through the heart, or as a pseudo-3D display on a video monitor. In order to administer treatment, the treating physician must build a 3D
picture in his or her mind based on the two-dimensional pictures that are displayed. The transposition is particularly tricky when therapy is to be administered inside the heart, such as local electrical ablation of aberrant electrical pathways, or laser myocardial revascularization.
It is also known in the art to map the heart using a mapping probe, typically a catheter, inside the heart chambers. Exemplary methods and devices for this purpose are described in U.S. Patents 5,471,982 and 5,391,199 and in PCT patent publications W094/06349, W096/05768 and W097/24981, U.S. Patent 5,391,199, for example, describes a catheter that includes both electrodes for sensing cardiac electrical activity and miniature coils for determining the position of the catheter relative to an externally-applied magnetic field. Using this catheter a cardiologist can collect data from a set of sampled points in the heart within a short period of time, by measuring the electrical activity at a plurality of locations and determining the spatial coordinates of the locations. Locations of the mapping catheter within the heart can be superimposed on a 3D reconstruction of an image of the heart, such as an ultrasound image, acquired prior to or during the catheter study. Color codes are used to represent electrical activity sensed by the catheter.
U.S. Patent 5,738,096 describes methods for geometrical mapping of the endocardium based on bringing a probe into contact with multiple locations on a wall of the heart, and determining position coordinates of the probe at each of the locations. The position coordinates are combined to form a map of at least a portion of the heart. Once the position of the catheter is known, external sensors can be used to provide local physiological values of heart tissue adjacent to the tip of the catheter. For example, if the catheter incorporates a radioactive marker suitable for SPECT, local functional information can be gleaned from a SPECT image. Yet another example is determining local perfusion from Doppler-ultrasound images of the coronaries, from nuclear medicine images or from X-ray or CT angiography, and overlaying the perfusion map on the geometrical map. The image of the catheter in the perfusion map can be used to align the perfusion map and the geometrical map. Alternatively, the alignment may be carried out using fiducial marks or anatomical reference locations, either automatically or manually.
Further methods for creating a three-dimensional map of the heart based on these data are disclosed, for example, in European patent application EP 0 974 936 and in a corresponding U.S. Patent No. 6,226,542, which is assigned to the assignee of the present patent application. As indicated in these applications, position coordinates (and optionally electrical activity, as well) are initially measured at about 10 to 20 points on the interior surface of the heart. These data points are generally sufficient to generate a preliminary reconstruction or map of the cardiac surface to a satisfactory quality. The preliminary map is preferably combined with data taken at additional points in order to generate a more comprehensive map.
SUMMARY OF THE INVENTION
It is an object of some aspects of the present invention to provide improved methods and apparatus for mapping and visualization of internal body structures, and particularly of the heart.
It is a further object of some aspects of the present invention to provide improved methods and apparatus for administering local treatment of pathological conditions within the heart.
In preferred embodiments of the present invention, a position-sensing catheter is used to generate a 3D geometrical map of the internal surface of a heart chamber of a subject. A 3D diagnostic image of the heart is captured in conjunction with generating the 3D map, typically either before or concurrently with the mapping. The image and map are brought into mutual registration, and diagnostic information from the image, such as perfusion information, is then marked on the 3D map, preferably in the form of color coding. Based on the combined diagnostic and geometrical information, a physician operating the catheter is able to identify and visualize areas of the heart that are in need of treatment, due to low perfusion, for example. The physician preferably uses the catheter to apply a local invasive therapy, such as laser revascularization, to specific points that are located using the color-coded 3D map. Alternatively, a local diagnostic technique, such as a biopsy, may be performed at such specific points.
s There is therefore provided, in accordance with a preferred embodiment of the present invention, a method for mapping a structure in a body of a subject, including:
capturing a three-dimensional (3D) image of the structure including diagnostic information;
generating a 3D geometrical map of the structure using a probe inserted into the structure;
registering the image with the map, such that each of a plurality of image points in the image is identified with a corresponding map point in the map;
and is displaying the map, such that the diagnostic information associated with each of the image points is displayed at the corresponding map point.
In a preferred embodiment, the diagnostic information is related to blood flow in the structure, wherein the diagnostic information includes local perfusion data. In other preferred embodiments, the diagnostic information includes metabolic data, or is related to uptake of a substance in tissue of the structure, or is related to motion of the structure.
Preferably, generating the geometrical map includes bringing the probe into contact with the structure at a multiplicity of locations on the structure, and recording position coordinates of the probe at the locations, wherein recording the position coordinates includes determining the coordinates using a position sensor in the probe.
-Preferably, registering the image with the map includes applying a transformation to at least one of the image and the map so that following the transformation, the image and the map have a common axis and a common scale.
Further preferably, registering the image with the map includes dividing the image 5 into a plurality of parallel planar slices, perpendicular to the axis and mutually spaced along the axis, wherein the plurality of image points are located in the slices.
More preferably, registering the image with the map includes finding an axial coordinate of each of the slices and an angular coordinate of each of the image points located in each of the slices, and identifying each of the image points with the io map point having the same axial and angular coordinates. Most preferably, the structure includes a wall defining a cavity, and identifying each of the image points with the map point includes finding, at the axial and the angular coordinate, the image point that is within a section of the wall. -is Preferably, displaying the map includes coloring the map to reflect the diagnostic information.
In a preferred embodiment, the method includes performing a medical procedure on the structure guided by the diagnostic information displayed on the 20 map. Preferably, performing the medical procedure includes using the probe to perform the procedure locally at locations selected on the geometrical map, and the method includes marking on the geometrical map the locations at which the procedure was performed. Additionally or alternatively, performing the medical procedure includes performing a therapeutic procedure, wherein the diagnostic 25 information relates to local blood flow in the structure, and wherein performing the therapeutic procedure includes performing a procedure for improving the local blood flow. Alternatively, performing the medical procedure includes performing a diagnostic procedure.
FIELD OF THE INVENTION
The present invention relates generally to systems and methods for three-dimensional mapping and reconstruction, and specifically to mapping and reconstruction of the interior of body organs, such as the heart.
BACKGROUND OF THE INVENTION
Various methods of diagnostic imaging are known in the art. Methods used for imaging the heart, for example, include fluoroscopy, angiography, echocardiography, computed tomography (CT), magnetic resonance imaging (MRI), positron emission tomography (PET) and single photon emission tomography (SPECT). Many of these methods produce three-dimensional (3D) image information, which can then be rendered for viewing in the form of parallel slices through the heart, or as a pseudo-3D display on a video monitor. In order to administer treatment, the treating physician must build a 3D
picture in his or her mind based on the two-dimensional pictures that are displayed. The transposition is particularly tricky when therapy is to be administered inside the heart, such as local electrical ablation of aberrant electrical pathways, or laser myocardial revascularization.
It is also known in the art to map the heart using a mapping probe, typically a catheter, inside the heart chambers. Exemplary methods and devices for this purpose are described in U.S. Patents 5,471,982 and 5,391,199 and in PCT patent publications W094/06349, W096/05768 and W097/24981, U.S. Patent 5,391,199, for example, describes a catheter that includes both electrodes for sensing cardiac electrical activity and miniature coils for determining the position of the catheter relative to an externally-applied magnetic field. Using this catheter a cardiologist can collect data from a set of sampled points in the heart within a short period of time, by measuring the electrical activity at a plurality of locations and determining the spatial coordinates of the locations. Locations of the mapping catheter within the heart can be superimposed on a 3D reconstruction of an image of the heart, such as an ultrasound image, acquired prior to or during the catheter study. Color codes are used to represent electrical activity sensed by the catheter.
U.S. Patent 5,738,096 describes methods for geometrical mapping of the endocardium based on bringing a probe into contact with multiple locations on a wall of the heart, and determining position coordinates of the probe at each of the locations. The position coordinates are combined to form a map of at least a portion of the heart. Once the position of the catheter is known, external sensors can be used to provide local physiological values of heart tissue adjacent to the tip of the catheter. For example, if the catheter incorporates a radioactive marker suitable for SPECT, local functional information can be gleaned from a SPECT image. Yet another example is determining local perfusion from Doppler-ultrasound images of the coronaries, from nuclear medicine images or from X-ray or CT angiography, and overlaying the perfusion map on the geometrical map. The image of the catheter in the perfusion map can be used to align the perfusion map and the geometrical map. Alternatively, the alignment may be carried out using fiducial marks or anatomical reference locations, either automatically or manually.
Further methods for creating a three-dimensional map of the heart based on these data are disclosed, for example, in European patent application EP 0 974 936 and in a corresponding U.S. Patent No. 6,226,542, which is assigned to the assignee of the present patent application. As indicated in these applications, position coordinates (and optionally electrical activity, as well) are initially measured at about 10 to 20 points on the interior surface of the heart. These data points are generally sufficient to generate a preliminary reconstruction or map of the cardiac surface to a satisfactory quality. The preliminary map is preferably combined with data taken at additional points in order to generate a more comprehensive map.
SUMMARY OF THE INVENTION
It is an object of some aspects of the present invention to provide improved methods and apparatus for mapping and visualization of internal body structures, and particularly of the heart.
It is a further object of some aspects of the present invention to provide improved methods and apparatus for administering local treatment of pathological conditions within the heart.
In preferred embodiments of the present invention, a position-sensing catheter is used to generate a 3D geometrical map of the internal surface of a heart chamber of a subject. A 3D diagnostic image of the heart is captured in conjunction with generating the 3D map, typically either before or concurrently with the mapping. The image and map are brought into mutual registration, and diagnostic information from the image, such as perfusion information, is then marked on the 3D map, preferably in the form of color coding. Based on the combined diagnostic and geometrical information, a physician operating the catheter is able to identify and visualize areas of the heart that are in need of treatment, due to low perfusion, for example. The physician preferably uses the catheter to apply a local invasive therapy, such as laser revascularization, to specific points that are located using the color-coded 3D map. Alternatively, a local diagnostic technique, such as a biopsy, may be performed at such specific points.
s There is therefore provided, in accordance with a preferred embodiment of the present invention, a method for mapping a structure in a body of a subject, including:
capturing a three-dimensional (3D) image of the structure including diagnostic information;
generating a 3D geometrical map of the structure using a probe inserted into the structure;
registering the image with the map, such that each of a plurality of image points in the image is identified with a corresponding map point in the map;
and is displaying the map, such that the diagnostic information associated with each of the image points is displayed at the corresponding map point.
In a preferred embodiment, the diagnostic information is related to blood flow in the structure, wherein the diagnostic information includes local perfusion data. In other preferred embodiments, the diagnostic information includes metabolic data, or is related to uptake of a substance in tissue of the structure, or is related to motion of the structure.
Preferably, generating the geometrical map includes bringing the probe into contact with the structure at a multiplicity of locations on the structure, and recording position coordinates of the probe at the locations, wherein recording the position coordinates includes determining the coordinates using a position sensor in the probe.
-Preferably, registering the image with the map includes applying a transformation to at least one of the image and the map so that following the transformation, the image and the map have a common axis and a common scale.
Further preferably, registering the image with the map includes dividing the image 5 into a plurality of parallel planar slices, perpendicular to the axis and mutually spaced along the axis, wherein the plurality of image points are located in the slices.
More preferably, registering the image with the map includes finding an axial coordinate of each of the slices and an angular coordinate of each of the image points located in each of the slices, and identifying each of the image points with the io map point having the same axial and angular coordinates. Most preferably, the structure includes a wall defining a cavity, and identifying each of the image points with the map point includes finding, at the axial and the angular coordinate, the image point that is within a section of the wall. -is Preferably, displaying the map includes coloring the map to reflect the diagnostic information.
In a preferred embodiment, the method includes performing a medical procedure on the structure guided by the diagnostic information displayed on the 20 map. Preferably, performing the medical procedure includes using the probe to perform the procedure locally at locations selected on the geometrical map, and the method includes marking on the geometrical map the locations at which the procedure was performed. Additionally or alternatively, performing the medical procedure includes performing a therapeutic procedure, wherein the diagnostic 25 information relates to local blood flow in the structure, and wherein performing the therapeutic procedure includes performing a procedure for improving the local blood flow. Alternatively, performing the medical procedure includes performing a diagnostic procedure.
Preferably, the structure includes a heart of the subject, and generating the geometrical map includes mapping an endocardial surface in a ventricle of the heart.
There is also provided, in accordance with a preferred embodiment of the present invention, apparatus for mapping a structure in a body of a subject, including:
an imaging device, adapted to capture a three-dimensional (3D) image of the structure including diagnostic information;
a probe, adapted to be inserted into the structure, so as to generate a 3D
geometrical map of the structure;
a processor, coupled to the probe and to the imaging device, and adapted to register the image with the map, such that each of a plurality of image points in the image is identified with a corresponding map point in the map; and a display, coupled to be driven by the processor to display the map, such that the diagnostic information associated with each of the image points is displayed at the corresponding map point.
In some aspects, there is provided a method for mapping a structure in a body of a subject, comprising:
capturing a three-dimensional (3D) image of the structure comprising diagnostic information;
providing a probe having a position sensor for determining position and orientation information of the probe, the probe being already positioned in the structure;
generating a 3D geometrical map of the structure using information sensed by the position sensor of the probe at multiple points on the structure, each point having position and orientation information associated therewith and defined as a map point on the map;
-6a-registering the image with the map, such that each of a plurality of image points in the image is identified with a corresponding map point in the map by performing a bullseye rendition of a stack of parallel slices of the image; and displaying the map, such that the diagnostic information associated with each of the image points is displayed at the corresponding map point.
In some aspects, there is provided an apparatus for mapping a structure in a body of a subject, comprising:
an imaging device, adapted to capture a three-dimensional (3D) image of the structure comprising diagnostic information;
a probe having a position sensor for determining position and orientation information of the probe and adapted to be inserted into the structure, so as to generate a 3D geometrical map of the structure based on position and orientation information using the position sensor;
a processor, coupled to the probe and to the imaging device, and adapted to register the 3D image with the 3D geometrical map by performing a bullseye rendition of a stack of parallel slices of the 3D image, such that each of a plurality of image points in the 3D image is identified with a corresponding map point in the 3D geometrical map; and a display, coupled to be driven by the processor to display the 3D geometrical map, such that the diagnostic information associated with each of the image points is displayed at the corresponding map point.
The present invention will be more fully understood from the following detailed description of the preferred embodiments thereof, taken together with the drawings in which:
-6b-BRIEF DESCRIPTION OF THE DRAWINGS
Fig. 1 is a schematic, pictorial illustration of a system for imaging, mapping and treatment of the heart, in accordance with a preferred embodiment of the present invention;
There is also provided, in accordance with a preferred embodiment of the present invention, apparatus for mapping a structure in a body of a subject, including:
an imaging device, adapted to capture a three-dimensional (3D) image of the structure including diagnostic information;
a probe, adapted to be inserted into the structure, so as to generate a 3D
geometrical map of the structure;
a processor, coupled to the probe and to the imaging device, and adapted to register the image with the map, such that each of a plurality of image points in the image is identified with a corresponding map point in the map; and a display, coupled to be driven by the processor to display the map, such that the diagnostic information associated with each of the image points is displayed at the corresponding map point.
In some aspects, there is provided a method for mapping a structure in a body of a subject, comprising:
capturing a three-dimensional (3D) image of the structure comprising diagnostic information;
providing a probe having a position sensor for determining position and orientation information of the probe, the probe being already positioned in the structure;
generating a 3D geometrical map of the structure using information sensed by the position sensor of the probe at multiple points on the structure, each point having position and orientation information associated therewith and defined as a map point on the map;
-6a-registering the image with the map, such that each of a plurality of image points in the image is identified with a corresponding map point in the map by performing a bullseye rendition of a stack of parallel slices of the image; and displaying the map, such that the diagnostic information associated with each of the image points is displayed at the corresponding map point.
In some aspects, there is provided an apparatus for mapping a structure in a body of a subject, comprising:
an imaging device, adapted to capture a three-dimensional (3D) image of the structure comprising diagnostic information;
a probe having a position sensor for determining position and orientation information of the probe and adapted to be inserted into the structure, so as to generate a 3D geometrical map of the structure based on position and orientation information using the position sensor;
a processor, coupled to the probe and to the imaging device, and adapted to register the 3D image with the 3D geometrical map by performing a bullseye rendition of a stack of parallel slices of the 3D image, such that each of a plurality of image points in the 3D image is identified with a corresponding map point in the 3D geometrical map; and a display, coupled to be driven by the processor to display the 3D geometrical map, such that the diagnostic information associated with each of the image points is displayed at the corresponding map point.
The present invention will be more fully understood from the following detailed description of the preferred embodiments thereof, taken together with the drawings in which:
-6b-BRIEF DESCRIPTION OF THE DRAWINGS
Fig. 1 is a schematic, pictorial illustration of a system for imaging, mapping and treatment of the heart, in accordance with a preferred embodiment of the present invention;
Fig. 2 is a flow chart that schematically illustrates a method for imaging, mapping and treating the heart, in accordance with a preferred embodiment of the present invention;
Fig. 3 is a schematic representation of a map of a chamber of the heart, in accordance with a preferred embodiment of the present invention;
Fig. 4 is a simplified geometrical representation of the map of Fig. 3, showing coordinates used in registering the map with an image of the heart, in accordance with a preferred embodiment of the present invention;
Fig. 5 is a schematic, exploded view of a 3D image of the heart, represented as a stack of parallel slices through the heart, in accordance with a preferred embodiment of the present invention;
Fig. 6 shows the slices of Fig. 5 arrayed side-by-side, illustrating registration of the slices with the 3D map of Fig. 3, in accordance with a preferred embodiment of the present invention; and Fig. 7 is a schematic representation of the map of Fig. 3, after coloring of the map with diagnostic information from the image of Figs. 5 and 6, in accordance with a preferred embodiment of the present invention.
DETAILED DESCRIPTION OF PREFERRED EMBODIMENTS
Fig. I is a schematic, pictorial illustration of a system 20 for three-dimensional geometrical mapping, imaging and treatment of a heart 24 of a subject 26, in accordance with a preferred embodiment of the present invention. System comprises an elongate probe, preferably a catheter 30, which is inserted by a user 22 through a vein or artery of the subject into a chamber of the heart.
Catheter 30 preferably comprises at least one position sensor (not shown in s the figures), most preferably located near the catheter's distal tip. The position sensor preferably comprises an electromagnetic sensor, which is mounted within the catheter by any suitable method, for example, using polyurethane glue or the like.
The sensor is electrically connected to an electromagnetic sensor cable, which extends through the catheter body and into a control handle of the catheter.
In the control handle, the wires of the sensor cable are connected to a circuit board (not shown), which amplifies the signals received from the electromagnetic sensor and transmits them to a computer housed in a console 34, in a form understandable to the computer. Because the catheter is designed for single use only, the circuit board preferably contains an EPROM chip, which shuts down the circuit board after the is catheter has been used. This prevents the catheter, or at least the electromagnetic sensor, from being used twice.
To use the electromagnetic sensor, subject 26 is placed in a magnetic field generated, for example, by situating under the patient a pad containing field generator coils 28 for generating a magnetic field, driven by driver circuits 32. A
reference electromagnetic sensor (not shown) is preferably fixed relative to the patient, e.g., taped to the patient's back, and catheter 30 containing its sensor is advanced into heart 24. The sensor preferably comprises three small coils, which in the magnetic field generate weak electrical signals indicative of their position in the magnetic field. Signals generated by both the fixed reference sensor and by the sensor in the heart are amplified and transmitted to console 34, which analyzes the signals and then displays the results on a monitor 36. By this method, the precise location of the sensor in the catheter relative to the reference sensor can be ascertained and visually displayed. The sensors can also detect displacement of the catheter that is caused by contraction of the heart muscle.
Suitable electromagnetic sensors for the purposes of the present invention are described, for example, in the above-mentioned U.S. Patent 5,391,199 and PCT
patent publication WO 96/05768. A preferred electromagnetic mapping sensor is manufactured by Biosense Ltd. (Tirat Hacarmel, Israel) and marketed under the trade designation NOGA. Some of the mapping features of catheter 30 and system 20 are implemented in the NOGA-STAR catheter marketed by Biosense Webster, Inc., and in the Biosense-NOGA system, also marketed by Biosense Webster, Inc.
Further aspects of the design of catheter 30 and of system 20 generally are described in U.S. patent No. 6,892,091 which is assigned to the assignee of the present patent application _ Using such sensors, system 20 achieves continuous generation of six dimensions of position and is orientation information with respect to catheter 30. Alternatively, the sensors used in catheter 20 may comprise other types of position and/or coordinate sensors, as described, for example, in U.S. Patent 5,391,199, 5,443,489 or 5,515,853, or in PCT
publication WO 94/04938 or WO 99/05971, or substantially any other suitable type of position/coordinate sensing device known in the art.
As noted above, catheter 30 is coupled to console 34, which enables the user to observe and regulate the functions of the catheter. Console 34 includes a processor, preferably a computer with appropriate signal processing circuits (which are typically contained inside a housing of the computer). The processor is coupled to drive display 36. User 22 brings the distal tip of catheter 30 into contact with multiple points on the endocardial surface of heart 24, and the position coordinates are recorded at each point. The information derived from this analysis is used to reconstruct a three-dimensional geometrical map 38 of the endocardial surface of heart 24.
System 20 also comprises a diagnostic imaging unit 48, such as an echo Doppler unit, SPECT, PET, MRI, CT or other imaging unit known in the art. Unit 48 is used to capture a 3D diagnostic image of heart 24, preferably while user 22 is mapping the heart using catheter 30. Alternatively, the diagnostic image is captured before beginning the mapping, and unit 48 may, in this case, be separate from the other elements of system 20. Diagnostic data from the image captured by unit are superimposed on map 38, using methods described hereinbelow. Depending on the type and configuration of unit 48, a wide range of different diagnostic data may be represented in the image, such as perfusion, metabolic factors, uptake of markers, heart wall motion or thickness, and/or other anatomical or electrical properties, as are known in the art. The image can also be timed to represent different phases in is the heart cycle.
Typically, system 20 includes other elements, some of which are not shown in the figures for the sake of simplicity. In the present embodiment, the system preferably includes a laser console 49, which is used in performing direct myocardial revascularization, as described, for example, in PCT patent application PCT/IL97/00011 and in U.S. patent No. 6,171,303 which is assigned to the assignee of the present patent application.
Console 49 injects laser energy into a suitable waveguide (not shown) within catheter 30. The waveguide conveys the energy to the distal tip of the catheter, where it is applied to revascularize areas of the myocardium suffering from low perfusion. Alternatively, the system may include other therapeutic elements, as are known in the art, particularly elements for delivering local treatment in the heart, such as a radio-frequency driver coupled to an ablation electrode on catheter 30; an ultrasound generator coupled to high-power transducer in the catheter, for ultrasonic ablation of the endocardium; or a supply of a therapeutic agent, such as growth factors for angiogenesis, coupled to an injection needle in the catheter. Still further alternatively, the system may include invasive diagnostic elements, such as biopsy forceps that are operated through catheter 30.
Other elements that may be comprised in system 20 are described, for example, in U.S. patent No. 6,221,542' which is assigned to the assignee of the present patent application, Typically, system 20 includes an ECG monitor (not shown), coupled to receive signals from one or more body surface electrodes, so as to provide an ECG
synchronization signal to console 34. As mentioned above, the system preferably also includes a reference position sensor, either on an externally-applied reference patch attached to the exterior of the patient's body, or on an internally-placed catheter, which is inserted into heart 24 and maintained in a fixed position relative to the heart. By comparing the position of catheter 30 to that of the reference catheter, the coordinates of catheter 30 are accurately determined relative to the heart, irrespective of heart motion. Alternatively, any other suitable method may be used to compensate for heart motion.
Fig. 2 is a flow chart that schematically illustrates a method for imaging, mapping and treatment of heart 24 using system 20, in accordance with a preferred embodiment of the present invention. At an imaging step 50, a diagnostic image of heart 24, such as a SPECT image, is captured. Preferably, although not necessarily, the image is captured while catheter 30 is already located inside the heart.
The catheter is used to generate geometrical map 38, at a mapping step 52.
Suitable mapping techniques for this purpose are described in the above-mentioned U.S.
Patent 5,738,096. The above-mentioned European patent application EP 0 974 936 and U.S. patent No. 6,226,542 describe accurate methods for creating the map itself based on the data gathered using catheter 30. The image captured at step 50 and the map created at step 52 are then registered one with the other, at a registration step 54.
Figs. 3 and 4 are schematic representations of map 38 generated by system 20 at step 52, illustrating a method used at registration step 54, in accordance with a preferred embodiment of the present invention. Fig. 3 is a wire frame rendition of the map, representing the left ventricle of heart 24. For the purposes of step 54, a longitudinal axis 72 is drawn through the map, passing through an apex 74 of the ventricle. Preferably, the axis and apex are found automatically by console 34.
Alternatively or additionally, these or other features of the map are identified manually by user 22.
Fig. 4 is a simplified geometrical representation of a surface 80 of map 38, generated for the purpose of registration with a diagnostic image of heart 24.
Surface 80 corresponds to an approximate locus of the endocardium of the heart, as determined from map 38. A coordinate system is defined in which each point 82 on surface 80 is represented by a distance R from apex 74 and an angle a relative to a downward direction 84 (i.e., the direction pointing toward the feet of subject 26).
In order to register the diagnostic image with map 38, axis 72 and apex 74 are identified in the image, as well, and are aligned with the axis and apex of the map. The identification is preferably automatic but may, alternatively or additionally, be carried out or assisted by user 22. Other landmarks and/or fiducial marks in the heart can also be used in performing the alignment. The scale of the image is adjusted so that its dimensions match those of the map as closely as possible. For many types of diagnostic images, such as perfusion maps, the resolution of the diagnostic information is low, so that imprecision of as much as 10 mm in mutual registration can be tolerated. When higher resolution is required, the registration of the diagnostic image with the geometrical map may be improved using methods of automatic registration such as those described in Appendix A.
s These methods are optional and are not essential to the present invention.
Fig. 5 is a schematic, exploded view of a 3D diagnostic image 90 of heart 24, following registration of the 3D image with geometrical map 38, in accordance with a preferred embodiment of the present invention. This view is generated at a bullseye rendition step 56 in the method of Fig. 2. The bullseye rendition of image 90 comprises a stack of parallel slices 92, which are perpendicular to axis 72. The slices are preferably taken at a fixed slice increment one from another along the axis.
Each slice shows a section 94 of image 90, at a distance R from apex 74 that is determined by the slice number.
u Fig. 6 shows slices 92 of image 90 arrayed side-by-side, illustrating extraction of diagnostic data from the slices for application to map 38, in accordance with a preferred embodiment of the present invention. Referring, for example, to slice number 5, sectional image 94 comprises three essential parts: an inner region 100, showing the inside of the ventricle; a wall region 102, showing the myocardium; and an outer region 104, external to the heart. The diagnostic information of interest is in region 102. Assuming image 90 to be a SPECT
image, showing perfusion in the heart wall, for example, region 102 will typically have the highest value of perfusion.
At a coloration transfer step 58, the diagnostic information from each slice 92 is transferred to map 38. Each slice has a known value of distance R from apex 74. For each angle a within the slice, point 82 on surface 80 of the map (Fig.
4) is assumed to be the point at that angle that is located radially in the middle of region 102. In the case that image 90 is a perfusion image, point 82 is simply taken to be the point of highest perfusion at the given angle. In other imaging modalities, finding region 102 is, for the most part, similarly straightforward. The value of the s diagnostic data at each point 82 is preferably represented as a color applied to the corresponding region of map 38.
Fig. 7 is a schematic representation of a colored geometrical map 110, as produced at step 58, in accordance with a preferred embodiment of the present invention. Because of the limited ability of a line drawing to convey qualities of a color image, only two different color regions appear on map 110: a well-perfused region 112, and an ischemic region 114. Preferably, the ischemic region has a darker or "cooler" color than the well-perfused region. In actual applications, in which display 36 comprises a color monitor, a broad range of different colors is used in map 110 to describe different levels of perfusion or of other diagnostic qualities.
Preferably, system 20 is operated by user 22 to carry out an invasive therapeutic procedure, guided by map 110, at a therapeutic step 60. In the present example, laser console 49 is operated to irradiate ischemic region 114 via catheter 30 with high-intensity laser radiation, as described in the above-mentioned PCT
patent application PCT/IL97/00011. The laser creates revascularization channels in the myocardium, which are marked by system 20 with spots 116 on map 110. The combination of the imaging, mapping and therapeutic modalities enables the user to concentrate the treatment in the region of heart 24 that is known to need it, and to ensure that the region is fully covered. Other local therapeutic and diagnostic procedures can similarly benefit from the guidance provided by map 110.
Fig. 3 is a schematic representation of a map of a chamber of the heart, in accordance with a preferred embodiment of the present invention;
Fig. 4 is a simplified geometrical representation of the map of Fig. 3, showing coordinates used in registering the map with an image of the heart, in accordance with a preferred embodiment of the present invention;
Fig. 5 is a schematic, exploded view of a 3D image of the heart, represented as a stack of parallel slices through the heart, in accordance with a preferred embodiment of the present invention;
Fig. 6 shows the slices of Fig. 5 arrayed side-by-side, illustrating registration of the slices with the 3D map of Fig. 3, in accordance with a preferred embodiment of the present invention; and Fig. 7 is a schematic representation of the map of Fig. 3, after coloring of the map with diagnostic information from the image of Figs. 5 and 6, in accordance with a preferred embodiment of the present invention.
DETAILED DESCRIPTION OF PREFERRED EMBODIMENTS
Fig. I is a schematic, pictorial illustration of a system 20 for three-dimensional geometrical mapping, imaging and treatment of a heart 24 of a subject 26, in accordance with a preferred embodiment of the present invention. System comprises an elongate probe, preferably a catheter 30, which is inserted by a user 22 through a vein or artery of the subject into a chamber of the heart.
Catheter 30 preferably comprises at least one position sensor (not shown in s the figures), most preferably located near the catheter's distal tip. The position sensor preferably comprises an electromagnetic sensor, which is mounted within the catheter by any suitable method, for example, using polyurethane glue or the like.
The sensor is electrically connected to an electromagnetic sensor cable, which extends through the catheter body and into a control handle of the catheter.
In the control handle, the wires of the sensor cable are connected to a circuit board (not shown), which amplifies the signals received from the electromagnetic sensor and transmits them to a computer housed in a console 34, in a form understandable to the computer. Because the catheter is designed for single use only, the circuit board preferably contains an EPROM chip, which shuts down the circuit board after the is catheter has been used. This prevents the catheter, or at least the electromagnetic sensor, from being used twice.
To use the electromagnetic sensor, subject 26 is placed in a magnetic field generated, for example, by situating under the patient a pad containing field generator coils 28 for generating a magnetic field, driven by driver circuits 32. A
reference electromagnetic sensor (not shown) is preferably fixed relative to the patient, e.g., taped to the patient's back, and catheter 30 containing its sensor is advanced into heart 24. The sensor preferably comprises three small coils, which in the magnetic field generate weak electrical signals indicative of their position in the magnetic field. Signals generated by both the fixed reference sensor and by the sensor in the heart are amplified and transmitted to console 34, which analyzes the signals and then displays the results on a monitor 36. By this method, the precise location of the sensor in the catheter relative to the reference sensor can be ascertained and visually displayed. The sensors can also detect displacement of the catheter that is caused by contraction of the heart muscle.
Suitable electromagnetic sensors for the purposes of the present invention are described, for example, in the above-mentioned U.S. Patent 5,391,199 and PCT
patent publication WO 96/05768. A preferred electromagnetic mapping sensor is manufactured by Biosense Ltd. (Tirat Hacarmel, Israel) and marketed under the trade designation NOGA. Some of the mapping features of catheter 30 and system 20 are implemented in the NOGA-STAR catheter marketed by Biosense Webster, Inc., and in the Biosense-NOGA system, also marketed by Biosense Webster, Inc.
Further aspects of the design of catheter 30 and of system 20 generally are described in U.S. patent No. 6,892,091 which is assigned to the assignee of the present patent application _ Using such sensors, system 20 achieves continuous generation of six dimensions of position and is orientation information with respect to catheter 30. Alternatively, the sensors used in catheter 20 may comprise other types of position and/or coordinate sensors, as described, for example, in U.S. Patent 5,391,199, 5,443,489 or 5,515,853, or in PCT
publication WO 94/04938 or WO 99/05971, or substantially any other suitable type of position/coordinate sensing device known in the art.
As noted above, catheter 30 is coupled to console 34, which enables the user to observe and regulate the functions of the catheter. Console 34 includes a processor, preferably a computer with appropriate signal processing circuits (which are typically contained inside a housing of the computer). The processor is coupled to drive display 36. User 22 brings the distal tip of catheter 30 into contact with multiple points on the endocardial surface of heart 24, and the position coordinates are recorded at each point. The information derived from this analysis is used to reconstruct a three-dimensional geometrical map 38 of the endocardial surface of heart 24.
System 20 also comprises a diagnostic imaging unit 48, such as an echo Doppler unit, SPECT, PET, MRI, CT or other imaging unit known in the art. Unit 48 is used to capture a 3D diagnostic image of heart 24, preferably while user 22 is mapping the heart using catheter 30. Alternatively, the diagnostic image is captured before beginning the mapping, and unit 48 may, in this case, be separate from the other elements of system 20. Diagnostic data from the image captured by unit are superimposed on map 38, using methods described hereinbelow. Depending on the type and configuration of unit 48, a wide range of different diagnostic data may be represented in the image, such as perfusion, metabolic factors, uptake of markers, heart wall motion or thickness, and/or other anatomical or electrical properties, as are known in the art. The image can also be timed to represent different phases in is the heart cycle.
Typically, system 20 includes other elements, some of which are not shown in the figures for the sake of simplicity. In the present embodiment, the system preferably includes a laser console 49, which is used in performing direct myocardial revascularization, as described, for example, in PCT patent application PCT/IL97/00011 and in U.S. patent No. 6,171,303 which is assigned to the assignee of the present patent application.
Console 49 injects laser energy into a suitable waveguide (not shown) within catheter 30. The waveguide conveys the energy to the distal tip of the catheter, where it is applied to revascularize areas of the myocardium suffering from low perfusion. Alternatively, the system may include other therapeutic elements, as are known in the art, particularly elements for delivering local treatment in the heart, such as a radio-frequency driver coupled to an ablation electrode on catheter 30; an ultrasound generator coupled to high-power transducer in the catheter, for ultrasonic ablation of the endocardium; or a supply of a therapeutic agent, such as growth factors for angiogenesis, coupled to an injection needle in the catheter. Still further alternatively, the system may include invasive diagnostic elements, such as biopsy forceps that are operated through catheter 30.
Other elements that may be comprised in system 20 are described, for example, in U.S. patent No. 6,221,542' which is assigned to the assignee of the present patent application, Typically, system 20 includes an ECG monitor (not shown), coupled to receive signals from one or more body surface electrodes, so as to provide an ECG
synchronization signal to console 34. As mentioned above, the system preferably also includes a reference position sensor, either on an externally-applied reference patch attached to the exterior of the patient's body, or on an internally-placed catheter, which is inserted into heart 24 and maintained in a fixed position relative to the heart. By comparing the position of catheter 30 to that of the reference catheter, the coordinates of catheter 30 are accurately determined relative to the heart, irrespective of heart motion. Alternatively, any other suitable method may be used to compensate for heart motion.
Fig. 2 is a flow chart that schematically illustrates a method for imaging, mapping and treatment of heart 24 using system 20, in accordance with a preferred embodiment of the present invention. At an imaging step 50, a diagnostic image of heart 24, such as a SPECT image, is captured. Preferably, although not necessarily, the image is captured while catheter 30 is already located inside the heart.
The catheter is used to generate geometrical map 38, at a mapping step 52.
Suitable mapping techniques for this purpose are described in the above-mentioned U.S.
Patent 5,738,096. The above-mentioned European patent application EP 0 974 936 and U.S. patent No. 6,226,542 describe accurate methods for creating the map itself based on the data gathered using catheter 30. The image captured at step 50 and the map created at step 52 are then registered one with the other, at a registration step 54.
Figs. 3 and 4 are schematic representations of map 38 generated by system 20 at step 52, illustrating a method used at registration step 54, in accordance with a preferred embodiment of the present invention. Fig. 3 is a wire frame rendition of the map, representing the left ventricle of heart 24. For the purposes of step 54, a longitudinal axis 72 is drawn through the map, passing through an apex 74 of the ventricle. Preferably, the axis and apex are found automatically by console 34.
Alternatively or additionally, these or other features of the map are identified manually by user 22.
Fig. 4 is a simplified geometrical representation of a surface 80 of map 38, generated for the purpose of registration with a diagnostic image of heart 24.
Surface 80 corresponds to an approximate locus of the endocardium of the heart, as determined from map 38. A coordinate system is defined in which each point 82 on surface 80 is represented by a distance R from apex 74 and an angle a relative to a downward direction 84 (i.e., the direction pointing toward the feet of subject 26).
In order to register the diagnostic image with map 38, axis 72 and apex 74 are identified in the image, as well, and are aligned with the axis and apex of the map. The identification is preferably automatic but may, alternatively or additionally, be carried out or assisted by user 22. Other landmarks and/or fiducial marks in the heart can also be used in performing the alignment. The scale of the image is adjusted so that its dimensions match those of the map as closely as possible. For many types of diagnostic images, such as perfusion maps, the resolution of the diagnostic information is low, so that imprecision of as much as 10 mm in mutual registration can be tolerated. When higher resolution is required, the registration of the diagnostic image with the geometrical map may be improved using methods of automatic registration such as those described in Appendix A.
s These methods are optional and are not essential to the present invention.
Fig. 5 is a schematic, exploded view of a 3D diagnostic image 90 of heart 24, following registration of the 3D image with geometrical map 38, in accordance with a preferred embodiment of the present invention. This view is generated at a bullseye rendition step 56 in the method of Fig. 2. The bullseye rendition of image 90 comprises a stack of parallel slices 92, which are perpendicular to axis 72. The slices are preferably taken at a fixed slice increment one from another along the axis.
Each slice shows a section 94 of image 90, at a distance R from apex 74 that is determined by the slice number.
u Fig. 6 shows slices 92 of image 90 arrayed side-by-side, illustrating extraction of diagnostic data from the slices for application to map 38, in accordance with a preferred embodiment of the present invention. Referring, for example, to slice number 5, sectional image 94 comprises three essential parts: an inner region 100, showing the inside of the ventricle; a wall region 102, showing the myocardium; and an outer region 104, external to the heart. The diagnostic information of interest is in region 102. Assuming image 90 to be a SPECT
image, showing perfusion in the heart wall, for example, region 102 will typically have the highest value of perfusion.
At a coloration transfer step 58, the diagnostic information from each slice 92 is transferred to map 38. Each slice has a known value of distance R from apex 74. For each angle a within the slice, point 82 on surface 80 of the map (Fig.
4) is assumed to be the point at that angle that is located radially in the middle of region 102. In the case that image 90 is a perfusion image, point 82 is simply taken to be the point of highest perfusion at the given angle. In other imaging modalities, finding region 102 is, for the most part, similarly straightforward. The value of the s diagnostic data at each point 82 is preferably represented as a color applied to the corresponding region of map 38.
Fig. 7 is a schematic representation of a colored geometrical map 110, as produced at step 58, in accordance with a preferred embodiment of the present invention. Because of the limited ability of a line drawing to convey qualities of a color image, only two different color regions appear on map 110: a well-perfused region 112, and an ischemic region 114. Preferably, the ischemic region has a darker or "cooler" color than the well-perfused region. In actual applications, in which display 36 comprises a color monitor, a broad range of different colors is used in map 110 to describe different levels of perfusion or of other diagnostic qualities.
Preferably, system 20 is operated by user 22 to carry out an invasive therapeutic procedure, guided by map 110, at a therapeutic step 60. In the present example, laser console 49 is operated to irradiate ischemic region 114 via catheter 30 with high-intensity laser radiation, as described in the above-mentioned PCT
patent application PCT/IL97/00011. The laser creates revascularization channels in the myocardium, which are marked by system 20 with spots 116 on map 110. The combination of the imaging, mapping and therapeutic modalities enables the user to concentrate the treatment in the region of heart 24 that is known to need it, and to ensure that the region is fully covered. Other local therapeutic and diagnostic procedures can similarly benefit from the guidance provided by map 110.
Although preferred embodiments are described hereinabove with reference to heart 24, the principles of the present invention may similarly be applied to imaging, mapping and treatment of other organs and body structures. It will thus be appreciated that the preferred embodiments described above are cited by way of example, and that the present invention is not limited to what has been particularly shown and described hereinabove. Rather, the scope of the present invention includes both combinations and subcombinations of the various features described hereinabove, as well as variations and modifications thereof which would occur to persons skilled in the art upon reading the foregoing description and which are not disclosed in the prior art.
APPENDIX A
This appendix provides details of step 54 in the method of Fig. 2, in which two 3D representations, P and Q, of a chamber of heart 24 are brought into mutual registration. To begin, a rough estimate is found for the transformation between P
and Q, either manually, or using the principle axis of a bounding ellipsoid or by principle component decomposition. The bounding ellipsoid technique is further described in the above-mentioned European patent application EP 0 974 936 and U.S. patent No. 6,226,542.
Fine registration between P and Q is then preferably found using a variation of the Iterative Closest Point (ICP) algorithm. This algorithm is described by Besl and McKay in "A Method for Registration of 3D Shapes," published in IEEE
Transactions on Pattern Analysis and Machine Intelligence 14(2):239-256 (1992), which is incorporated herein by reference. The following steps are repeated until convergence:
APPENDIX A
This appendix provides details of step 54 in the method of Fig. 2, in which two 3D representations, P and Q, of a chamber of heart 24 are brought into mutual registration. To begin, a rough estimate is found for the transformation between P
and Q, either manually, or using the principle axis of a bounding ellipsoid or by principle component decomposition. The bounding ellipsoid technique is further described in the above-mentioned European patent application EP 0 974 936 and U.S. patent No. 6,226,542.
Fine registration between P and Q is then preferably found using a variation of the Iterative Closest Point (ICP) algorithm. This algorithm is described by Besl and McKay in "A Method for Registration of 3D Shapes," published in IEEE
Transactions on Pattern Analysis and Machine Intelligence 14(2):239-256 (1992), which is incorporated herein by reference. The following steps are repeated until convergence:
1. Nearest point search: For each point p in P find the closest point q on Q.
One can take a subset of points of P to improve computation speed.
Similarly, all points of Q can be covered, too, to ensure robustness.
2. Compute registration: Evaluate a transformation T that minimizes the sum of squared distances between pairs of closest points (p,q). The transformation is preferably either rigid, similarity, affine or projective as described below.
3. Transform: Apply the transformation T to all points in P.
Given two surfaces, P and Q, and two sets of points, {pi E P}i =1 {qi E Q}1=1, step 2 of this algorithm seeks a transformation, T, from a family of transformations (according to the possible families described below) that minimizes the mean square error, e, between the corresponding sets:
n 62 = n IIqi - T(Pi 1112 i=1 Affine and Projective Transformations For affine transformations, defined as T(p) = Ap + t, all a12 a13 tl A = a21 a21 a23 is a 3 x 3 matrix, and t = t2 is a translation vector.
ca31 a3 2 a33, t3 xil We must minimize E2 = 1 n ilgi - (Api + tJ12 . Denoting pi = xi2 i=1 xi3 Yil and qi = yi2 , we have three systems of equations:
Yi3 X11 X1_ X13 1 all y U
X21 X22 X23 1 aj2 = y2j j = 1 2 3 õ
a j3 Xn1 Xn2 Xi3 1 tj X aj }j Let a singular value decomposition of X be X = UDVT . It then follows that ai = VDUT yj Projective transformations are evaluated in a similar way to the affine case.
Similarity and Rigid Transformation Whereas in affine transforms triangles are transformed to triangles, similarity transformations preserve proportions. We seek a scaling factor, c, a 3 x 3 rotation matrix, R, and a 3-dimensional translation vector, t, such that T(p) = cRp +
t, n 2 wherein the error E2 (R, T, c) = n Ilgi - (cRpi + t~l is minimized.
i=1 A suitable method for finding the desired similarity transform is described by Umeyama, in "Least-Squares Estimation of Transformation Parameters Between Two Point Patterns," published in IEEE Transactions on Pattern Analysis and Machine Intelligence, 13(4): 376-380 (1991), Define the center of mass of both P and Q:
1 n Pp =-~Pi n i=1 1 n f~q = - Y qi n i=1 Then define the variance of the points on both P and Q:
n CrP n Z IIPi PPII2 z=1 Cr2 n = nZIlgi -pgII2 i=1 The covariance matrix between the two surfaces is n Zpq = 1 (qi - Pq) ( - ftP) z=1 Let a singular value decomposition of EPq be E pq = UDV , and T
One can take a subset of points of P to improve computation speed.
Similarly, all points of Q can be covered, too, to ensure robustness.
2. Compute registration: Evaluate a transformation T that minimizes the sum of squared distances between pairs of closest points (p,q). The transformation is preferably either rigid, similarity, affine or projective as described below.
3. Transform: Apply the transformation T to all points in P.
Given two surfaces, P and Q, and two sets of points, {pi E P}i =1 {qi E Q}1=1, step 2 of this algorithm seeks a transformation, T, from a family of transformations (according to the possible families described below) that minimizes the mean square error, e, between the corresponding sets:
n 62 = n IIqi - T(Pi 1112 i=1 Affine and Projective Transformations For affine transformations, defined as T(p) = Ap + t, all a12 a13 tl A = a21 a21 a23 is a 3 x 3 matrix, and t = t2 is a translation vector.
ca31 a3 2 a33, t3 xil We must minimize E2 = 1 n ilgi - (Api + tJ12 . Denoting pi = xi2 i=1 xi3 Yil and qi = yi2 , we have three systems of equations:
Yi3 X11 X1_ X13 1 all y U
X21 X22 X23 1 aj2 = y2j j = 1 2 3 õ
a j3 Xn1 Xn2 Xi3 1 tj X aj }j Let a singular value decomposition of X be X = UDVT . It then follows that ai = VDUT yj Projective transformations are evaluated in a similar way to the affine case.
Similarity and Rigid Transformation Whereas in affine transforms triangles are transformed to triangles, similarity transformations preserve proportions. We seek a scaling factor, c, a 3 x 3 rotation matrix, R, and a 3-dimensional translation vector, t, such that T(p) = cRp +
t, n 2 wherein the error E2 (R, T, c) = n Ilgi - (cRpi + t~l is minimized.
i=1 A suitable method for finding the desired similarity transform is described by Umeyama, in "Least-Squares Estimation of Transformation Parameters Between Two Point Patterns," published in IEEE Transactions on Pattern Analysis and Machine Intelligence, 13(4): 376-380 (1991), Define the center of mass of both P and Q:
1 n Pp =-~Pi n i=1 1 n f~q = - Y qi n i=1 Then define the variance of the points on both P and Q:
n CrP n Z IIPi PPII2 z=1 Cr2 n = nZIlgi -pgII2 i=1 The covariance matrix between the two surfaces is n Zpq = 1 (qi - Pq) ( - ftP) z=1 Let a singular value decomposition of EPq be E pq = UDV , and T
I if det(U) det(V) = 1 S =
diag(1,1,-1) if det(U) det(V) = -1 The rotation, translation and scaling of the transformation are then given by:
R = USVT
t = Pq - cR u c = 2 trace(DS) cp s wherein the trace of a matrix is the sum of its diagonal elements.
In the case of rigid transformation no scaling is applied, so that c = 1.
diag(1,1,-1) if det(U) det(V) = -1 The rotation, translation and scaling of the transformation are then given by:
R = USVT
t = Pq - cR u c = 2 trace(DS) cp s wherein the trace of a matrix is the sum of its diagonal elements.
In the case of rigid transformation no scaling is applied, so that c = 1.
Claims (40)
1. A method for mapping a structure in a body of a subject, comprising:
capturing a three-dimensional (3D) image of the structure comprising diagnostic information;
providing a probe having a position sensor for determining position and orientation information of the probe, the probe being already positioned in the structure;
generating a 3D geometrical map of the structure using information sensed by the position sensor of the probe at multiple points on the structure, each point having position and orientation information associated therewith and defined as a map point on the map;
registering the image with the map, such that each of a plurality of image points in the image is identified with a corresponding map point in the map by performing a bullseye rendition, the bullseye rendition including a stack of parallel slices of the image perpendicular to and aligned with an axis of the map; and displaying the map, such that the diagnostic information associated with each of the image points is displayed at the corresponding map point.
capturing a three-dimensional (3D) image of the structure comprising diagnostic information;
providing a probe having a position sensor for determining position and orientation information of the probe, the probe being already positioned in the structure;
generating a 3D geometrical map of the structure using information sensed by the position sensor of the probe at multiple points on the structure, each point having position and orientation information associated therewith and defined as a map point on the map;
registering the image with the map, such that each of a plurality of image points in the image is identified with a corresponding map point in the map by performing a bullseye rendition, the bullseye rendition including a stack of parallel slices of the image perpendicular to and aligned with an axis of the map; and displaying the map, such that the diagnostic information associated with each of the image points is displayed at the corresponding map point.
2. A method according to claim 1, wherein the diagnostic information is related to blood flow in the structure.
3. A method according to claim 2, wherein the diagnostic information comprises local perfusion data.
4. A method according to claim 1, wherein the diagnostic information comprises metabolic data.
5. A method according to claim 1, wherein the diagnostic information is related to uptake of a substance in tissue of the structure.
6. A method according to claim 1, wherein the diagnostic information is related to motion of the structure.
7. A method according to claim 1, wherein generating the geometrical map comprises recording position coordinates of the probe at a multiplicity of locations on the structure.
8. A method according to claim 7, wherein recording the position coordinates comprises determining the coordinates using the position sensor in the probe.
9. A method according to claim 1, wherein registering the image with the map comprises applying a transformation to at least one of the image and the map so that following the transformation, the image and the map have a common axis and a common scale.
10. A method according to claim 9, wherein registering the image with the map comprises dividing the image into a plurality of parallel planar slices, perpendicular to the axis and mutually spaced along the axis, and wherein the plurality of image points are located in the slices.
11. A method according to claim 10, wherein registering the image with the map comprises finding an axial coordinate of each of the slices and an angular coordinate of each of the image points located in each of the slices, and identifying each of the image points with the map point having the same axial and angular coordinates.
12. A method according to claim 11, wherein the structure comprises a wall defining a cavity, and wherein identifying each of the image points with the map point comprises finding, at the axial and the angular coordinate, the image point that is within a section of the wall.
13. A method according to claim 1, wherein displaying the map comprises coloring the map to reflect the diagnostic information.
14. A method according to claim 1, wherein the diagnostic information displayed on the map is suitable for guiding a medical procedure.
15. A method according to claim 14, wherein the probe is adapted to perform the procedure locally at locations selected on the geometrical map.
16. A method according to claim 15, and comprising marking on the geometrical map the locations at which the procedure was performed.
17. A method according to claim 15, wherein the medical procedure is a therapeutic procedure.
18. A method according to claim 17, wherein the diagnostic information relates to local blood flow in the structure, and wherein the therapeutic procedure is a procedure for improving the local blood flow.
19. A method according to claim 15, wherein performing the medical procedure comprises performing a diagnostic procedure.
20. A method according to claim 1, wherein the structure comprises a heart of the subject, and wherein generating the geometrical map comprises mapping an endocardial surface in a ventricle of the heart.
21. Apparatus for mapping a structure in a body of a subject, comprising:
an imaging device, adapted to capture a three-dimensional (3D) image of the structure comprising diagnostic information;
a probe having a position sensor for determining position and orientation information of the probe and adapted to be inserted into the structure, so as to generate a 3D geometrical map of the structure based on position and orientation information using the position sensor;
a processor, coupled to the probe and to the imaging device, and adapted to register the 3D image with the 3D geometrical map by performing a bullseye rendition, the bullseye rendition including a stack of parallel slices of the 3D image perpendicular to and aligned with an axis of the 3D geometrical map, such that each of a plurality of image points in the 3D image is identified with a corresponding map point in the 3D geometrical map; and a display, coupled to be driven by the processor to display the 3D geometrical map, such that the diagnostic information associated with each of the image points is displayed at the corresponding map point.
an imaging device, adapted to capture a three-dimensional (3D) image of the structure comprising diagnostic information;
a probe having a position sensor for determining position and orientation information of the probe and adapted to be inserted into the structure, so as to generate a 3D geometrical map of the structure based on position and orientation information using the position sensor;
a processor, coupled to the probe and to the imaging device, and adapted to register the 3D image with the 3D geometrical map by performing a bullseye rendition, the bullseye rendition including a stack of parallel slices of the 3D image perpendicular to and aligned with an axis of the 3D geometrical map, such that each of a plurality of image points in the 3D image is identified with a corresponding map point in the 3D geometrical map; and a display, coupled to be driven by the processor to display the 3D geometrical map, such that the diagnostic information associated with each of the image points is displayed at the corresponding map point.
22. Apparatus according to claim 21, wherein the diagnostic information is related to blood flow in the structure.
23. Apparatus according to claim 22, wherein the diagnostic information comprises local perfusion data.
24. Apparatus according to claim 21, wherein the diagnostic information comprises metabolic data.
25. Apparatus according to claim 21, wherein the diagnostic information is related to uptake of a substance in tissue of the structure.
26. Apparatus according to claim 21, wherein the diagnostic information is related to motion of the structure.
27. Apparatus according to claim 21, wherein to generate the geometrical map, the probe is brought into contact with the structure at a multiplicity of locations on the structure, and the processor records position coordinates of the probe at the locations.
28. Apparatus according to claim 27, wherein the position sensor is used for determining position information in the form of position coordinates.
29. Apparatus according to claim 21, wherein the processor is adapted to register the image with the map by applying a transformation to at least one of the image and the map so that following the transformation, the image and the map have a common axis and a common scale.
30. Apparatus according to claim 29, wherein the processor is further adapted to divide the image into a plurality of parallel planar slices, perpendicular to the axis and mutually spaced along the axis, wherein the plurality of image points are located in the slices.
31. Apparatus according to claim 30, wherein the processor is adapted to find an axial coordinate of each of the slices and an angular coordinate of each of the image points located in each of the slices, and to identify each of the image points with the map point having the same axial and angular coordinates.
32. Apparatus according to claim 31, wherein the structure comprises a wall defining a cavity, and wherein the processor is adapted to identify each of the image points with the map point by finding, at the axial and the angular coordinate, the image point that is within a section of the wall.
33. Apparatus according to claim 21, wherein the map is colored to reflect the diagnostic information.
34. Apparatus according to claim 21, and comprising a medical instrument adapted to perform a medical procedure on the structure guided by the diagnostic information displayed on the map.
35. Apparatus according to claim 34, wherein the medical instrument is contained in the probe, which is adapted to be used to perform the procedure locally at locations selected on the geometrical map.
36. Apparatus according to claim 35, wherein the processor is adapted to mark on the geometrical map the locations at which the procedure was performed.
37. Apparatus according to claim 35, wherein the medical procedure comprises a therapeutic procedure.
38. Apparatus according to claim 37, wherein the diagnostic information relates to local blood flow in the structure, and wherein the therapeutic procedure comprises a procedure for improving the local blood flow.
39. Apparatus according to claim 35, wherein the medical procedure comprises a diagnostic procedure.
40. Apparatus according to claim 21, wherein the geometrical map comprises a map of an endocardial surface in a ventricle of the heart.
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Families Citing this family (235)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7189208B1 (en) * | 1992-09-23 | 2007-03-13 | Endocardial Solutions, Inc. | Method for measuring heart electrophysiology |
US7930012B2 (en) * | 1992-09-23 | 2011-04-19 | St. Jude Medical, Atrial Fibrillation Division, Inc. | Chamber location method |
EP0661948B1 (en) * | 1992-09-23 | 1997-11-19 | Endocardial Solutions, Inc. | Endocardial mapping system |
US7806829B2 (en) | 1998-06-30 | 2010-10-05 | St. Jude Medical, Atrial Fibrillation Division, Inc. | System and method for navigating an ultrasound catheter to image a beating heart |
US7286866B2 (en) * | 2001-11-05 | 2007-10-23 | Ge Medical Systems Global Technology Company, Llc | Method, system and computer product for cardiac interventional procedure planning |
US8175680B2 (en) | 2001-11-09 | 2012-05-08 | Boston Scientific Scimed, Inc. | Systems and methods for guiding catheters using registered images |
US20050075567A1 (en) * | 2001-12-18 | 2005-04-07 | Koninklijke Philips Electronics N.V. | Ultrasonic diagnostic imaging system with assisted border tracing |
US7311705B2 (en) | 2002-02-05 | 2007-12-25 | Medtronic, Inc. | Catheter apparatus for treatment of heart arrhythmia |
DE10210647A1 (en) * | 2002-03-11 | 2003-10-02 | Siemens Ag | Method for displaying an image of an instrument inserted into an area of a patient under examination uses a C-arch fitted with a source of X-rays and a ray detector. |
US7499743B2 (en) * | 2002-03-15 | 2009-03-03 | General Electric Company | Method and system for registration of 3D images within an interventional system |
US7346381B2 (en) * | 2002-11-01 | 2008-03-18 | Ge Medical Systems Global Technology Company Llc | Method and apparatus for medical intervention procedure planning |
US7998062B2 (en) | 2004-03-29 | 2011-08-16 | Superdimension, Ltd. | Endoscope structures and techniques for navigating to a target in branched structure |
US20040003432A1 (en) * | 2002-05-06 | 2004-01-01 | Pharmacia Corporation | Production of hexosamines and uses thereof |
US7778686B2 (en) * | 2002-06-04 | 2010-08-17 | General Electric Company | Method and apparatus for medical intervention procedure planning and location and navigation of an intervention tool |
US7450746B2 (en) * | 2002-06-07 | 2008-11-11 | Verathon Inc. | System and method for cardiac imaging |
US8221322B2 (en) | 2002-06-07 | 2012-07-17 | Verathon Inc. | Systems and methods to improve clarity in ultrasound images |
GB2391625A (en) | 2002-08-09 | 2004-02-11 | Diagnostic Ultrasound Europ B | Instantaneous ultrasonic echo measurement of bladder urine volume with a limited number of ultrasound beams |
US7819806B2 (en) | 2002-06-07 | 2010-10-26 | Verathon Inc. | System and method to identify and measure organ wall boundaries |
US8221321B2 (en) | 2002-06-07 | 2012-07-17 | Verathon Inc. | Systems and methods for quantification and classification of fluids in human cavities in ultrasound images |
US7117026B2 (en) * | 2002-06-12 | 2006-10-03 | Koninklijke Philips Electronics N.V. | Physiological model based non-rigid image registration |
US7306593B2 (en) * | 2002-10-21 | 2007-12-11 | Biosense, Inc. | Prediction and assessment of ablation of cardiac tissue |
US7001383B2 (en) * | 2002-10-21 | 2006-02-21 | Biosense, Inc. | Real-time monitoring and mapping of ablation lesion formation in the heart |
US20070055142A1 (en) * | 2003-03-14 | 2007-03-08 | Webler William E | Method and apparatus for image guided position tracking during percutaneous procedures |
US7747047B2 (en) | 2003-05-07 | 2010-06-29 | Ge Medical Systems Global Technology Company, Llc | Cardiac CT system and method for planning left atrial appendage isolation |
US7565190B2 (en) * | 2003-05-09 | 2009-07-21 | Ge Medical Systems Global Technology Company, Llc | Cardiac CT system and method for planning atrial fibrillation intervention |
US7343196B2 (en) * | 2003-05-09 | 2008-03-11 | Ge Medical Systems Global Technology Company Llc | Cardiac CT system and method for planning and treatment of biventricular pacing using epicardial lead |
US7344543B2 (en) * | 2003-07-01 | 2008-03-18 | Medtronic, Inc. | Method and apparatus for epicardial left atrial appendage isolation in patients with atrial fibrillation |
US7813785B2 (en) | 2003-07-01 | 2010-10-12 | General Electric Company | Cardiac imaging system and method for planning minimally invasive direct coronary artery bypass surgery |
US20050010105A1 (en) * | 2003-07-01 | 2005-01-13 | Sra Jasbir S. | Method and system for Coronary arterial intervention |
JP3802018B2 (en) * | 2003-07-10 | 2006-07-26 | ザイオソフト株式会社 | Image analysis apparatus, image analysis program, and image analysis method |
DE10340546B4 (en) | 2003-09-01 | 2006-04-20 | Siemens Ag | Method and apparatus for visually assisting electrophysiology catheter application in the heart |
EP2316328B1 (en) | 2003-09-15 | 2012-05-09 | Super Dimension Ltd. | Wrap-around holding device for use with bronchoscopes |
US9089261B2 (en) | 2003-09-15 | 2015-07-28 | Covidien Lp | System of accessories for use with bronchoscopes |
US7308299B2 (en) * | 2003-10-22 | 2007-12-11 | General Electric Company | Method, apparatus and product for acquiring cardiac images |
US20050096515A1 (en) * | 2003-10-23 | 2005-05-05 | Geng Z. J. | Three-dimensional surface image guided adaptive therapy system |
US7308297B2 (en) | 2003-11-05 | 2007-12-11 | Ge Medical Systems Global Technology Company, Llc | Cardiac imaging system and method for quantification of desynchrony of ventricles for biventricular pacing |
US20050143777A1 (en) * | 2003-12-19 | 2005-06-30 | Sra Jasbir S. | Method and system of treatment of heart failure using 4D imaging |
US20050137661A1 (en) * | 2003-12-19 | 2005-06-23 | Sra Jasbir S. | Method and system of treatment of cardiac arrhythmias using 4D imaging |
US7787951B1 (en) | 2003-12-24 | 2010-08-31 | Pacesetter, Inc. | System and method for determining optimal stimulation sites based on ECG information |
US7454248B2 (en) * | 2004-01-30 | 2008-11-18 | Ge Medical Systems Global Technology, Llc | Method, apparatus and product for acquiring cardiac images |
US8764725B2 (en) | 2004-02-09 | 2014-07-01 | Covidien Lp | Directional anchoring mechanism, method and applications thereof |
US7374536B1 (en) | 2004-04-16 | 2008-05-20 | Taylor Colin R | Method for analysis of pain images |
US8702626B1 (en) | 2004-04-21 | 2014-04-22 | Acclarent, Inc. | Guidewires for performing image guided procedures |
US20190314620A1 (en) | 2004-04-21 | 2019-10-17 | Acclarent, Inc. | Apparatus and methods for dilating and modifying ostia of paranasal sinuses and other intranasal or paranasal structures |
US20060063973A1 (en) | 2004-04-21 | 2006-03-23 | Acclarent, Inc. | Methods and apparatus for treating disorders of the ear, nose and throat |
US7654997B2 (en) | 2004-04-21 | 2010-02-02 | Acclarent, Inc. | Devices, systems and methods for diagnosing and treating sinusitus and other disorders of the ears, nose and/or throat |
US7803150B2 (en) | 2004-04-21 | 2010-09-28 | Acclarent, Inc. | Devices, systems and methods useable for treating sinusitis |
DE102004020587B4 (en) * | 2004-04-27 | 2016-02-18 | Siemens Aktiengesellschaft | Method and apparatus for visually assisting a catheter electrophysiology application with 2D fluoroscopic images |
EP1761901A1 (en) * | 2004-05-17 | 2007-03-14 | Koninklijke Philips Electronics N.V. | A medical imaging system for mapping a structure in a patient's body |
US7633502B2 (en) * | 2004-05-19 | 2009-12-15 | Boston Scientific Scimed, Inc. | System and method for graphically representing anatomical orifices and vessels |
US8515527B2 (en) * | 2004-10-13 | 2013-08-20 | General Electric Company | Method and apparatus for registering 3D models of anatomical regions of a heart and a tracking system with projection images of an interventional fluoroscopic system |
US7327872B2 (en) * | 2004-10-13 | 2008-02-05 | General Electric Company | Method and system for registering 3D models of anatomical regions with projection images of the same |
US7713210B2 (en) * | 2004-11-23 | 2010-05-11 | St. Jude Medical, Atrial Fibrillation Division, Inc. | Method and apparatus for localizing an ultrasound catheter |
JP5122743B2 (en) * | 2004-12-20 | 2013-01-16 | ゼネラル・エレクトリック・カンパニイ | System for aligning 3D images within an interventional system |
EP1846896B1 (en) | 2004-12-20 | 2019-03-13 | Philips Intellectual Property & Standards GmbH | A method, a system and a computer program for integration of medical diagnostic information and a geometric model of a movable body |
JP5345782B2 (en) | 2005-01-11 | 2013-11-20 | ヴォルケイノウ・コーポレーション | Blood vessel information acquisition device |
US7715604B2 (en) * | 2005-01-18 | 2010-05-11 | Siemens Medical Solutions Usa, Inc. | System and method for automatically registering three dimensional cardiac images with electro-anatomical cardiac mapping data |
DE102005014854A1 (en) * | 2005-03-30 | 2006-10-12 | Siemens Ag | Method for providing measurement data for the targeted local positioning of a catheter |
EP1903944B1 (en) | 2005-06-24 | 2017-04-19 | Volcano Corporation | Co-registration of graphical image data representing three-dimensional vascular features |
DE102005032755B4 (en) * | 2005-07-13 | 2014-09-04 | Siemens Aktiengesellschaft | System for performing and monitoring minimally invasive procedures |
US20070016029A1 (en) * | 2005-07-15 | 2007-01-18 | General Electric Company | Physiology workstation with real-time fluoroscopy and ultrasound imaging |
US7569015B2 (en) * | 2005-07-15 | 2009-08-04 | General Electric Company | Integrated physiology and imaging workstation |
CN100445488C (en) * | 2005-08-01 | 2008-12-24 | 邱则有 | Hollow member for cast-in-situ concrete moulding |
US7877128B2 (en) * | 2005-08-02 | 2011-01-25 | Biosense Webster, Inc. | Simulation of invasive procedures |
US8583220B2 (en) * | 2005-08-02 | 2013-11-12 | Biosense Webster, Inc. | Standardization of catheter-based treatment for atrial fibrillation |
US8406851B2 (en) * | 2005-08-11 | 2013-03-26 | Accuray Inc. | Patient tracking using a virtual image |
US20070043596A1 (en) * | 2005-08-16 | 2007-02-22 | General Electric Company | Physiology network and workstation for use therewith |
US7740584B2 (en) * | 2005-08-16 | 2010-06-22 | The General Electric Company | Method and system for mapping physiology information onto ultrasound-based anatomic structure |
US20070049817A1 (en) * | 2005-08-30 | 2007-03-01 | Assaf Preiss | Segmentation and registration of multimodal images using physiological data |
DE102005042329A1 (en) * | 2005-09-06 | 2007-03-08 | Siemens Ag | Electro-physiological catheter application assistance providing method, involves detecting contour of areas relevant for catheter application, and showing areas as simple line in representations of mapping and/or image data |
US8229545B2 (en) | 2005-09-15 | 2012-07-24 | St. Jude Medical, Atrial Fibrillation Division, Inc. | System and method for mapping complex fractionated electrogram information |
US8038625B2 (en) * | 2005-09-15 | 2011-10-18 | St. Jude Medical, Atrial Fibrillation Division, Inc. | System and method for three-dimensional mapping of electrophysiology information |
US7918793B2 (en) * | 2005-10-28 | 2011-04-05 | Biosense Webster, Inc. | Synchronization of ultrasound imaging data with electrical mapping |
US20070106147A1 (en) * | 2005-11-01 | 2007-05-10 | Altmann Andres C | Controlling direction of ultrasound imaging catheter |
US8303505B2 (en) | 2005-12-02 | 2012-11-06 | Abbott Cardiovascular Systems Inc. | Methods and apparatuses for image guided medical procedures |
US7855723B2 (en) * | 2006-03-21 | 2010-12-21 | Biosense Webster, Inc. | Image registration using locally-weighted fitting |
US8075486B2 (en) | 2006-05-03 | 2011-12-13 | Biosense Webster, Inc. | Enhanced ultrasound image display |
US7988639B2 (en) * | 2006-05-17 | 2011-08-02 | St. Jude Medical, Atrial Fibrillation Division, Inc. | System and method for complex geometry modeling of anatomy using multiple surface models |
US7515954B2 (en) | 2006-06-13 | 2009-04-07 | Rhythmia Medical, Inc. | Non-contact cardiac mapping, including moving catheter and multi-beat integration |
US7505810B2 (en) | 2006-06-13 | 2009-03-17 | Rhythmia Medical, Inc. | Non-contact cardiac mapping, including preprocessing |
US7729752B2 (en) | 2006-06-13 | 2010-06-01 | Rhythmia Medical, Inc. | Non-contact cardiac mapping, including resolution map |
US9370312B2 (en) * | 2006-09-06 | 2016-06-21 | Biosense Webster, Inc. | Correlation of cardiac electrical maps with body surface measurements |
US7996060B2 (en) * | 2006-10-09 | 2011-08-09 | Biosense Webster, Inc. | Apparatus, method, and computer software product for registration of images of an organ using anatomical features outside the organ |
MX2009003918A (en) * | 2006-10-10 | 2009-05-08 | Biosense Webster Inc | Esophageal mapping catheter. |
WO2008048780A1 (en) * | 2006-10-16 | 2008-04-24 | Massachusetts Institute Of Technology | Method and apparatus for localizing an object in the body |
US9129359B2 (en) * | 2006-11-10 | 2015-09-08 | Covidien Lp | Adaptive navigation technique for navigating a catheter through a body channel or cavity |
DE102006056687A1 (en) * | 2006-11-30 | 2008-05-08 | Siemens Ag | Heart's electro anatomical image recording and representation method for c-arc x-ray device, involves statistically visualizing information obtained from cardiogram at electrodes position in representation of three dimensional data set |
US7831076B2 (en) | 2006-12-08 | 2010-11-09 | Biosense Webster, Inc. | Coloring electroanatomical maps to indicate ultrasound data acquisition |
US20080167639A1 (en) * | 2007-01-08 | 2008-07-10 | Superdimension Ltd. | Methods for localized intra-body treatment of tissue |
US20080190438A1 (en) | 2007-02-08 | 2008-08-14 | Doron Harlev | Impedance registration and catheter tracking |
US7715907B2 (en) * | 2007-03-02 | 2010-05-11 | Siemens Medical Solutions Usa, Inc. | Method and system for atrial fibrillation analysis, characterization, and mapping |
JP4559501B2 (en) * | 2007-03-14 | 2010-10-06 | 富士フイルム株式会社 | Cardiac function display device, cardiac function display method and program thereof |
US8527032B2 (en) | 2007-05-16 | 2013-09-03 | General Electric Company | Imaging system and method of delivery of an instrument to an imaged subject |
US8167803B2 (en) | 2007-05-16 | 2012-05-01 | Verathon Inc. | System and method for bladder detection using harmonic imaging |
US8989842B2 (en) * | 2007-05-16 | 2015-03-24 | General Electric Company | System and method to register a tracking system with intracardiac echocardiography (ICE) imaging system |
US8428690B2 (en) * | 2007-05-16 | 2013-04-23 | General Electric Company | Intracardiac echocardiography image reconstruction in combination with position tracking system |
US20080287783A1 (en) * | 2007-05-16 | 2008-11-20 | General Electric Company | System and method of tracking delivery of an imaging probe |
US20080287909A1 (en) * | 2007-05-17 | 2008-11-20 | Viswanathan Raju R | Method and apparatus for intra-chamber needle injection treatment |
US8364242B2 (en) * | 2007-05-17 | 2013-01-29 | General Electric Company | System and method of combining ultrasound image acquisition with fluoroscopic image acquisition |
US8057394B2 (en) | 2007-06-30 | 2011-11-15 | St. Jude Medical, Atrial Fibrillation Division, Inc. | Ultrasound image processing to render three-dimensional images from two-dimensional images |
EP2192855B1 (en) | 2007-07-09 | 2020-03-25 | Covidien LP | Patent breathing modeling |
JP5599709B2 (en) | 2007-09-03 | 2014-10-01 | コーニンクレッカ フィリップス エヌ ヴェ | Visualization of voxel data |
US8905920B2 (en) | 2007-09-27 | 2014-12-09 | Covidien Lp | Bronchoscope adapter and method |
JP5337367B2 (en) * | 2007-10-31 | 2013-11-06 | 株式会社東芝 | Medical image display device |
US10299753B2 (en) | 2007-11-29 | 2019-05-28 | Biosense Webster, Inc. | Flashlight view of an anatomical structure |
DE102007059601B4 (en) * | 2007-12-11 | 2011-06-22 | Siemens AG, 80333 | Diagnostic device comprising an imaging diagnostic device and an electromagnetic localization system and method for processing diagnostic image data |
WO2009079602A1 (en) | 2007-12-17 | 2009-06-25 | St. Jude Medical, Atrial Fibrillation Division, Inc. | Systems and methods for modeling both unobstructed and obstructed portions of a catheter |
US8103327B2 (en) | 2007-12-28 | 2012-01-24 | Rhythmia Medical, Inc. | Cardiac mapping catheter |
US9445772B2 (en) | 2007-12-31 | 2016-09-20 | St. Jude Medical, Atrial Fibrillatin Division, Inc. | Reduced radiation fluoroscopic system |
US8538509B2 (en) | 2008-04-02 | 2013-09-17 | Rhythmia Medical, Inc. | Intracardiac tracking system |
WO2009122273A2 (en) | 2008-04-03 | 2009-10-08 | Superdimension, Ltd. | Magnetic interference detection system and method |
US8218846B2 (en) | 2008-05-15 | 2012-07-10 | Superdimension, Ltd. | Automatic pathway and waypoint generation and navigation method |
WO2009147671A1 (en) | 2008-06-03 | 2009-12-10 | Superdimension Ltd. | Feature-based registration method |
US8218847B2 (en) | 2008-06-06 | 2012-07-10 | Superdimension, Ltd. | Hybrid registration method |
US8932207B2 (en) | 2008-07-10 | 2015-01-13 | Covidien Lp | Integrated multi-functional endoscopic tool |
US8200466B2 (en) | 2008-07-21 | 2012-06-12 | The Board Of Trustees Of The Leland Stanford Junior University | Method for tuning patient-specific cardiovascular simulations |
CA2957778C (en) | 2008-08-07 | 2022-12-13 | Jongtae Yuk | Device, system, and method to measure abdominal aortic aneurysm diameter |
US20100063400A1 (en) | 2008-09-05 | 2010-03-11 | Anne Lindsay Hall | Method and apparatus for catheter guidance using a combination of ultrasound and x-ray imaging |
US8137343B2 (en) * | 2008-10-27 | 2012-03-20 | Rhythmia Medical, Inc. | Tracking system using field mapping |
EP2348979B1 (en) * | 2008-11-07 | 2019-10-30 | Cardioinsight Technologies, Inc. | Visualization of physiological data for virtual electrodes |
EP2345024B1 (en) | 2008-11-10 | 2017-11-08 | Cardioinsight Technologies, Inc. | Visualization of electrophysiology data |
US8611984B2 (en) | 2009-04-08 | 2013-12-17 | Covidien Lp | Locatable catheter |
US9398862B2 (en) | 2009-04-23 | 2016-07-26 | Rhythmia Medical, Inc. | Multi-electrode mapping system |
US8571647B2 (en) | 2009-05-08 | 2013-10-29 | Rhythmia Medical, Inc. | Impedance based anatomy generation |
US8103338B2 (en) | 2009-05-08 | 2012-01-24 | Rhythmia Medical, Inc. | Impedance based anatomy generation |
JP5859431B2 (en) | 2009-06-08 | 2016-02-10 | エムアールアイ・インターヴェンションズ,インコーポレイテッド | MRI guided intervention system capable of tracking flexible internal devices and generating dynamic visualization in near real time |
US8369930B2 (en) | 2009-06-16 | 2013-02-05 | MRI Interventions, Inc. | MRI-guided devices and MRI-guided interventional systems that can track and generate dynamic visualizations of the devices in near real time |
WO2011044248A2 (en) * | 2009-10-06 | 2011-04-14 | Cardiofocus, Inc. | Cardiac ablation image analysis system and process |
JP5650248B2 (en) * | 2010-02-01 | 2015-01-07 | コビディエン エルピー | Region expansion algorithm |
US20110213260A1 (en) * | 2010-02-26 | 2011-09-01 | Pacesetter, Inc. | Crt lead placement based on optimal branch selection and optimal site selection |
US8694074B2 (en) | 2010-05-11 | 2014-04-08 | Rhythmia Medical, Inc. | Electrode displacement determination |
US10582834B2 (en) | 2010-06-15 | 2020-03-10 | Covidien Lp | Locatable expandable working channel and method |
US8315812B2 (en) | 2010-08-12 | 2012-11-20 | Heartflow, Inc. | Method and system for patient-specific modeling of blood flow |
US8157742B2 (en) | 2010-08-12 | 2012-04-17 | Heartflow, Inc. | Method and system for patient-specific modeling of blood flow |
US9002442B2 (en) | 2011-01-13 | 2015-04-07 | Rhythmia Medical, Inc. | Beat alignment and selection for cardiac mapping |
US9277872B2 (en) | 2011-01-13 | 2016-03-08 | Rhythmia Medical, Inc. | Electroanatomical mapping |
JP6166663B2 (en) * | 2011-03-02 | 2017-07-19 | コーニンクレッカ フィリップス エヌ ヴェKoninklijke Philips N.V. | Visualization for navigation guidance |
US8972228B2 (en) | 2011-05-03 | 2015-03-03 | Medtronic, Inc. | Assessing intra-cardiac activation patterns |
KR101239294B1 (en) * | 2011-05-23 | 2013-03-05 | 한양대학교 산학협력단 | Apparatus and method for registering images at coordinate space |
US9131853B2 (en) | 2011-07-01 | 2015-09-15 | Joseph Tiano | Medical probe and method of using same |
EP2765916B1 (en) | 2011-10-12 | 2019-02-13 | The Johns Hopkins University | System for evaluating regional cardiac function and dyssynchrony from a dynamic imaging modality using endocardial motion |
US8548778B1 (en) | 2012-05-14 | 2013-10-01 | Heartflow, Inc. | Method and system for providing information from a patient-specific model of blood flow |
US10827983B2 (en) * | 2012-10-30 | 2020-11-10 | The Johns Hopkins University | System and method for personalized cardiac arrhythmia risk assessment by simulating arrhythmia inducibility |
KR102001219B1 (en) * | 2012-11-26 | 2019-07-17 | 삼성전자주식회사 | Method and Apparatus of matching medical images |
US9050056B2 (en) | 2012-12-26 | 2015-06-09 | Biosense Webster (Israel) Ltd. | Reduced X-ray exposure by simulating images |
US9924884B2 (en) | 2013-04-30 | 2018-03-27 | Medtronic, Inc. | Systems, methods, and interfaces for identifying effective electrodes |
US10064567B2 (en) | 2013-04-30 | 2018-09-04 | Medtronic, Inc. | Systems, methods, and interfaces for identifying optimal electrical vectors |
CN105324067B (en) | 2013-05-06 | 2017-10-24 | 波士顿科学医学有限公司 | In real time or playback electric physiological data visualization during nearest bouncing characteristic it is continuously display |
WO2014185977A1 (en) | 2013-05-14 | 2014-11-20 | Boston Scientific Scimed Inc. | Representation and identification of activity patterns during electro-physiology mapping using vector fields |
US10251555B2 (en) | 2013-06-12 | 2019-04-09 | Medtronic, Inc. | Implantable electrode location selection |
US9877789B2 (en) | 2013-06-12 | 2018-01-30 | Medtronic, Inc. | Implantable electrode location selection |
WO2015057521A1 (en) | 2013-10-14 | 2015-04-23 | Boston Scientific Scimed, Inc. | High resolution cardiac mapping electrode array catheter |
US10206601B2 (en) | 2013-12-09 | 2019-02-19 | Medtronic, Inc. | Noninvasive cardiac therapy evaluation |
US9776009B2 (en) | 2014-03-20 | 2017-10-03 | Medtronic, Inc. | Non-invasive detection of phrenic nerve stimulation |
WO2015149042A1 (en) * | 2014-03-28 | 2015-10-01 | Dorin Panescu | Alignment of q3d models with 3d images |
JP6609616B2 (en) | 2014-03-28 | 2019-11-20 | インテュイティブ サージカル オペレーションズ, インコーポレイテッド | Quantitative 3D imaging of surgical scenes from a multiport perspective |
WO2015149043A1 (en) | 2014-03-28 | 2015-10-01 | Dorin Panescu | Quantitative three-dimensional imaging and printing of surgical implants |
CN106535812B (en) | 2014-03-28 | 2020-01-21 | 直观外科手术操作公司 | Surgical system with haptic feedback based on quantitative three-dimensional imaging |
KR102397254B1 (en) | 2014-03-28 | 2022-05-12 | 인튜어티브 서지컬 오퍼레이션즈 인코포레이티드 | Quantitative three-dimensional imaging of surgical scenes |
KR102387096B1 (en) | 2014-03-28 | 2022-04-15 | 인튜어티브 서지컬 오퍼레이션즈 인코포레이티드 | Quantitative three-dimensional visualization of instruments in a field of view |
WO2015187386A1 (en) | 2014-06-03 | 2015-12-10 | Boston Scientific Scimed, Inc. | Electrode assembly having an atraumatic distal tip |
WO2015187430A2 (en) | 2014-06-04 | 2015-12-10 | Boston Scientific Scimed, Inc. | Electrode assembly |
US10952593B2 (en) | 2014-06-10 | 2021-03-23 | Covidien Lp | Bronchoscope adapter |
AU2015284303B2 (en) | 2014-07-02 | 2019-07-25 | Covidien Lp | System and method for detecting trachea |
JP6534193B2 (en) | 2014-07-02 | 2019-06-26 | コヴィディエン リミテッド パートナーシップ | Real-time automatic registration feedback |
US9770216B2 (en) | 2014-07-02 | 2017-09-26 | Covidien Lp | System and method for navigating within the lung |
US20160000414A1 (en) | 2014-07-02 | 2016-01-07 | Covidien Lp | Methods for marking biopsy location |
US9754367B2 (en) | 2014-07-02 | 2017-09-05 | Covidien Lp | Trachea marking |
CA2953146A1 (en) | 2014-07-02 | 2016-01-07 | Covidien Lp | System and method for segmentation of lung |
US9603668B2 (en) | 2014-07-02 | 2017-03-28 | Covidien Lp | Dynamic 3D lung map view for tool navigation inside the lung |
US9591982B2 (en) | 2014-07-31 | 2017-03-14 | Medtronic, Inc. | Systems and methods for evaluating cardiac therapy |
US9586050B2 (en) | 2014-08-15 | 2017-03-07 | Medtronic, Inc. | Systems and methods for configuration of atrioventricular interval |
US9764143B2 (en) | 2014-08-15 | 2017-09-19 | Medtronic, Inc. | Systems and methods for configuration of interventricular interval |
US9586052B2 (en) | 2014-08-15 | 2017-03-07 | Medtronic, Inc. | Systems and methods for evaluating cardiac therapy |
US11253178B2 (en) | 2015-01-29 | 2022-02-22 | Medtronic, Inc. | Noninvasive assessment of cardiac resynchronization therapy |
US10426555B2 (en) | 2015-06-03 | 2019-10-01 | Covidien Lp | Medical instrument with sensor for use in a system and method for electromagnetic navigation |
WO2017031197A1 (en) | 2015-08-20 | 2017-02-23 | Boston Scientific Scimed Inc. | Flexible electrode for cardiac sensing and method for making |
US10986990B2 (en) | 2015-09-24 | 2021-04-27 | Covidien Lp | Marker placement |
US10405766B2 (en) * | 2015-09-26 | 2019-09-10 | Boston Scientific Scimed, Inc. | Method of exploring or mapping internal cardiac structures |
US10271757B2 (en) | 2015-09-26 | 2019-04-30 | Boston Scientific Scimed Inc. | Multiple rhythm template monitoring |
CN108024747B (en) | 2015-09-26 | 2020-12-04 | 波士顿科学医学有限公司 | Intracardiac EGM signal for beat matching and acceptance |
EP3353753A1 (en) | 2015-09-26 | 2018-08-01 | Boston Scientific Scimed Inc. | Systems and methods for anatomical shell editing |
US10709352B2 (en) | 2015-10-27 | 2020-07-14 | Covidien Lp | Method of using lung airway carina locations to improve ENB registration |
US11219769B2 (en) | 2016-02-26 | 2022-01-11 | Medtronic, Inc. | Noninvasive methods and systems of determining the extent of tissue capture from cardiac pacing |
US10780279B2 (en) | 2016-02-26 | 2020-09-22 | Medtronic, Inc. | Methods and systems of optimizing right ventricular only pacing for patients with respect to an atrial event and left ventricular event |
US10478254B2 (en) | 2016-05-16 | 2019-11-19 | Covidien Lp | System and method to access lung tissue |
US11389254B2 (en) | 2016-08-18 | 2022-07-19 | Envizion Medical Ltd. | Insertion device positioning guidance system and method |
IL254009A0 (en) | 2016-08-18 | 2017-09-28 | Nutriseal Lp | Insertion device positioning guidance system and method |
US10615500B2 (en) | 2016-10-28 | 2020-04-07 | Covidien Lp | System and method for designing electromagnetic navigation antenna assemblies |
US10722311B2 (en) | 2016-10-28 | 2020-07-28 | Covidien Lp | System and method for identifying a location and/or an orientation of an electromagnetic sensor based on a map |
US10638952B2 (en) | 2016-10-28 | 2020-05-05 | Covidien Lp | Methods, systems, and computer-readable media for calibrating an electromagnetic navigation system |
US10446931B2 (en) | 2016-10-28 | 2019-10-15 | Covidien Lp | Electromagnetic navigation antenna assembly and electromagnetic navigation system including the same |
US10792106B2 (en) | 2016-10-28 | 2020-10-06 | Covidien Lp | System for calibrating an electromagnetic navigation system |
US10517505B2 (en) | 2016-10-28 | 2019-12-31 | Covidien Lp | Systems, methods, and computer-readable media for optimizing an electromagnetic navigation system |
US10418705B2 (en) | 2016-10-28 | 2019-09-17 | Covidien Lp | Electromagnetic navigation antenna assembly and electromagnetic navigation system including the same |
US10751126B2 (en) | 2016-10-28 | 2020-08-25 | Covidien Lp | System and method for generating a map for electromagnetic navigation |
US10395382B2 (en) | 2016-12-30 | 2019-08-27 | Biosense Webster (Israel) Ltd. | Visualization of distances on an electroanatomical map |
US10102665B2 (en) | 2016-12-30 | 2018-10-16 | Biosense Webster (Israel) Ltd. | Selecting points on an electroanatomical map |
US10532213B2 (en) | 2017-03-03 | 2020-01-14 | Medtronic, Inc. | Criteria for determination of local tissue latency near pacing electrode |
US10987517B2 (en) | 2017-03-15 | 2021-04-27 | Medtronic, Inc. | Detection of noise signals in cardiac signals |
US10765371B2 (en) | 2017-03-31 | 2020-09-08 | Biosense Webster (Israel) Ltd. | Method to project a two dimensional image/photo onto a 3D reconstruction, such as an epicardial view of heart |
CN111050841B (en) | 2017-07-28 | 2023-09-26 | 美敦力公司 | Cardiac cycle selection |
CN110996784B (en) | 2017-07-28 | 2023-05-30 | 美敦力公司 | Generating activation times |
US10682181B2 (en) * | 2017-09-06 | 2020-06-16 | Biosense Webster (Israel) Ltd. | Methods and systems for modeling and registration of 3-dimensional images of the heart |
US11219489B2 (en) | 2017-10-31 | 2022-01-11 | Covidien Lp | Devices and systems for providing sensors in parallel with medical tools |
US10492705B2 (en) | 2017-12-22 | 2019-12-03 | Regents Of The University Of Minnesota | Anterior and posterior electrode signals |
US10786167B2 (en) | 2017-12-22 | 2020-09-29 | Medtronic, Inc. | Ectopic beat-compensated electrical heterogeneity information |
US10799703B2 (en) | 2017-12-22 | 2020-10-13 | Medtronic, Inc. | Evaluation of his bundle pacing therapy |
US11419539B2 (en) | 2017-12-22 | 2022-08-23 | Regents Of The University Of Minnesota | QRS onset and offset times and cycle selection using anterior and posterior electrode signals |
US10433746B2 (en) | 2017-12-22 | 2019-10-08 | Regents Of The University Of Minnesota | Systems and methods for anterior and posterior electrode signal analysis |
US11141567B2 (en) * | 2018-01-16 | 2021-10-12 | Boston Scientific Scimed Inc. | Electrical arrangements for sensor assemblies in electromagnetic navigation systems |
US11224392B2 (en) | 2018-02-01 | 2022-01-18 | Covidien Lp | Mapping disease spread |
US10617318B2 (en) | 2018-02-27 | 2020-04-14 | Medtronic, Inc. | Mapping electrical activity on a model heart |
US10668290B2 (en) | 2018-03-01 | 2020-06-02 | Medtronic, Inc. | Delivery of pacing therapy by a cardiac pacing device |
US10918870B2 (en) | 2018-03-07 | 2021-02-16 | Medtronic, Inc. | Atrial lead placement for treatment of atrial dyssynchrony |
US10780281B2 (en) | 2018-03-23 | 2020-09-22 | Medtronic, Inc. | Evaluation of ventricle from atrium pacing therapy |
CN111902082A (en) | 2018-03-29 | 2020-11-06 | 美敦力公司 | Left ventricular assist device adjustment and evaluation |
US10548815B2 (en) | 2018-04-30 | 2020-02-04 | Envizion Medical Ltd. | Insertion device positioning guidance system and method |
US11304641B2 (en) | 2018-06-01 | 2022-04-19 | Medtronic, Inc. | Systems, methods, and interfaces for use in cardiac evaluation |
US10940321B2 (en) | 2018-06-01 | 2021-03-09 | Medtronic, Inc. | Systems, methods, and interfaces for use in cardiac evaluation |
US11382701B2 (en) | 2018-10-17 | 2022-07-12 | Envizion Medical Ltd. | Insertion device positioning guidance system and method |
JP7085093B2 (en) | 2018-10-17 | 2022-06-16 | エンヴィジョン メディカル リミテッド | Insertion device Positioning guidance system and method |
IL272254B2 (en) | 2019-02-15 | 2023-04-01 | Biosense Webster Israel Ltd | Transesophageal catheter with carbon dioxide delivery system for thermal protection of esophagus |
US10849696B2 (en) * | 2019-03-01 | 2020-12-01 | Biosense Webster (Israel) Ltd. | Map of body cavity |
US11697025B2 (en) | 2019-03-29 | 2023-07-11 | Medtronic, Inc. | Cardiac conduction system capture |
US11547858B2 (en) | 2019-03-29 | 2023-01-10 | Medtronic, Inc. | Systems, methods, and devices for adaptive cardiac therapy |
US11497431B2 (en) | 2019-10-09 | 2022-11-15 | Medtronic, Inc. | Systems and methods for configuring cardiac therapy |
US11642533B2 (en) | 2019-11-04 | 2023-05-09 | Medtronic, Inc. | Systems and methods for evaluating cardiac therapy |
US20210186601A1 (en) | 2019-12-23 | 2021-06-24 | Ethicon, Inc. | Transesophageal Catheter for Thermal Protection of the Esophagus |
US20210187242A1 (en) | 2019-12-23 | 2021-06-24 | Ethicon, Inc. | Fluid Delivery System for Creating Separation Between Biological Surfaces |
US20210186642A1 (en) | 2019-12-23 | 2021-06-24 | Ethicon, Inc. | Esophageal Protection Pathways |
US11813464B2 (en) | 2020-07-31 | 2023-11-14 | Medtronic, Inc. | Cardiac conduction system evaluation |
US20220133228A1 (en) | 2020-11-03 | 2022-05-05 | Biosense Webster (Israel) Ltd. | Identification and visualization of non-navigated objects in medical images |
US20220175459A1 (en) * | 2020-12-08 | 2022-06-09 | Envizion Medical Ltd. | Guidance system with claviculae position sensors |
WO2022264011A1 (en) | 2021-06-14 | 2022-12-22 | Ethicon, Inc. | Catheter with carbon dioxide delivery system and methods |
Family Cites Families (93)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR1344459A (en) | 1962-10-18 | 1963-11-29 | Method and apparatus for the electrical study of living organisms | |
US4157572A (en) | 1977-09-12 | 1979-06-05 | University Of Pittsburgh | Superimposition of television images |
US4459990A (en) | 1982-01-26 | 1984-07-17 | Elscint, Incorporated | Radiographic method and apparatus for the visualization of the interior of a body particularly useful for the visualization of a subject's circulatory system |
US4522212A (en) | 1983-11-14 | 1985-06-11 | Mansfield Scientific, Inc. | Endocardial electrode |
US4630203A (en) | 1983-12-27 | 1986-12-16 | Thomas Szirtes | Contour radiography: a system for determining 3-dimensional contours of an object from its 2-dimensional images |
US4682603A (en) | 1984-03-06 | 1987-07-28 | Franz Michael R | Apparatus and method for recording monophasic action potentials from an in vivo heart |
US4979510A (en) | 1984-03-06 | 1990-12-25 | Ep Technologies, Inc. | Apparatus and method for recording monophasic action potentials from an in vivo heart |
US4955382A (en) | 1984-03-06 | 1990-09-11 | Ep Technologies | Apparatus and method for recording monophasic action potentials from an in vivo heart |
US4628937A (en) | 1984-08-02 | 1986-12-16 | Cordis Corporation | Mapping electrode assembly |
US4660571A (en) | 1985-07-18 | 1987-04-28 | Cordis Corporation | Percutaneous lead having radially adjustable electrode |
US4699147A (en) | 1985-09-25 | 1987-10-13 | Cordis Corporation | Intraventricular multielectrode cardial mapping probe and method for using same |
DE3536658A1 (en) | 1985-10-15 | 1987-04-16 | Kessler Manfred | METHOD FOR REPRESENTING ELECTROCARDIOGRAPHIC VALUES |
US4762124A (en) | 1986-10-28 | 1988-08-09 | Kimberly-Clark Corporation | Liquid dispensing pouch |
US5215103A (en) | 1986-11-14 | 1993-06-01 | Desai Jawahar M | Catheter for mapping and ablation and method therefor |
US5231995A (en) | 1986-11-14 | 1993-08-03 | Desai Jawahar M | Method for catheter mapping and ablation |
US4940064A (en) | 1986-11-14 | 1990-07-10 | Desai Jawahar M | Catheter for mapping and ablation and method therefor |
US4878115A (en) | 1987-09-25 | 1989-10-31 | University Of Kentucky Research Foundation | Dynamic coronary roadmapping |
US4922912A (en) | 1987-10-21 | 1990-05-08 | Hideto Watanabe | MAP catheter |
US4875165A (en) | 1987-11-27 | 1989-10-17 | University Of Chicago | Method for determination of 3-D structure in biplane angiography |
US5588432A (en) | 1988-03-21 | 1996-12-31 | Boston Scientific Corporation | Catheters for imaging, sensing electrical potentials, and ablating tissue |
US4962767A (en) | 1988-07-05 | 1990-10-16 | Cardiac Control Systems, Inc. | Pacemaker catheter |
US5127403A (en) | 1988-07-05 | 1992-07-07 | Cardiac Control Systems, Inc. | Pacemaker catheter utilizing bipolar electrodes spaced in accordance to the length of a heart depolarization signal |
US5227969A (en) | 1988-08-01 | 1993-07-13 | W. L. Systems, Inc. | Manipulable three-dimensional projection imaging method |
FR2636451A1 (en) | 1988-09-13 | 1990-03-16 | Gen Electric Cgr | METHOD FOR RECONSTRUCTION OF THREE-DIMENSIONAL TREE BY LABELING |
JPH02114776A (en) | 1988-10-25 | 1990-04-26 | Toshiba Corp | X-ray diagnostic device |
JPH0538723Y2 (en) | 1988-12-19 | 1993-09-30 | ||
US4911174A (en) | 1989-02-13 | 1990-03-27 | Cardiac Pacemakers, Inc. | Method for matching the sense length of an impedance measuring catheter to a ventricular chamber |
US4905705A (en) | 1989-03-03 | 1990-03-06 | Research Triangle Institute | Impedance cardiometer |
EP0419729A1 (en) | 1989-09-29 | 1991-04-03 | Siemens Aktiengesellschaft | Position finding of a catheter by means of non-ionising fields |
CA2260688A1 (en) | 1989-11-21 | 1991-05-21 | I.S.G. Technologies, Inc. | Probe-correlated viewing of anatomical image data |
US5038791A (en) | 1990-06-11 | 1991-08-13 | Battelle Memorial Institute | Heart imaging method |
US5228442A (en) | 1991-02-15 | 1993-07-20 | Cardiac Pathways Corporation | Method for mapping, ablation, and stimulation using an endocardial catheter |
US5345936A (en) | 1991-02-15 | 1994-09-13 | Cardiac Pathways Corporation | Apparatus with basket assembly for endocardial mapping |
US5156151A (en) | 1991-02-15 | 1992-10-20 | Cardiac Pathways Corporation | Endocardial mapping and ablation system and catheter probe |
US5255678A (en) | 1991-06-21 | 1993-10-26 | Ecole Polytechnique | Mapping electrode balloon |
US5383917A (en) | 1991-07-05 | 1995-01-24 | Jawahar M. Desai | Device and method for multi-phase radio-frequency ablation |
US5555883A (en) | 1992-02-24 | 1996-09-17 | Avitall; Boaz | Loop electrode array mapping and ablation catheter for cardiac chambers |
US5239999A (en) | 1992-03-27 | 1993-08-31 | Cardiac Pathways Corporation | Helical endocardial catheter probe |
US5255679A (en) | 1992-06-02 | 1993-10-26 | Cardiac Pathways Corporation | Endocardial catheter for mapping and/or ablation with an expandable basket structure having means for providing selective reinforcement and pressure sensing mechanism for use therewith, and method |
US5324284A (en) | 1992-06-05 | 1994-06-28 | Cardiac Pathways, Inc. | Endocardial mapping and ablation system utilizing a separately controlled ablation catheter and method |
US5341807A (en) | 1992-06-30 | 1994-08-30 | American Cardiac Ablation Co., Inc. | Ablation catheter positioning system |
US5243981A (en) | 1992-07-13 | 1993-09-14 | Medtronic, Inc. | Myocardial conduction velocity rate responsive pacemaker |
WO1994004938A1 (en) | 1992-08-14 | 1994-03-03 | British Telecommunications Public Limited Company | Position location system |
EP0661948B1 (en) | 1992-09-23 | 1997-11-19 | Endocardial Solutions, Inc. | Endocardial mapping system |
US5311866A (en) | 1992-09-23 | 1994-05-17 | Endocardial Therapeutics, Inc. | Heart mapping catheter |
US5297549A (en) | 1992-09-23 | 1994-03-29 | Endocardial Therapeutics, Inc. | Endocardial mapping system |
US5293869A (en) | 1992-09-25 | 1994-03-15 | Ep Technologies, Inc. | Cardiac probe with dynamic support for maintaining constant surface contact during heart systole and diastole |
US5313943A (en) | 1992-09-25 | 1994-05-24 | Ep Technologies, Inc. | Catheters and methods for performing cardiac diagnosis and treatment |
US5471982A (en) | 1992-09-29 | 1995-12-05 | Ep Technologies, Inc. | Cardiac mapping and ablation systems |
US5687737A (en) * | 1992-10-09 | 1997-11-18 | Washington University | Computerized three-dimensional cardiac mapping with interactive visual displays |
US5433198A (en) | 1993-03-11 | 1995-07-18 | Desai; Jawahar M. | Apparatus and method for cardiac ablation |
US5657755A (en) | 1993-03-11 | 1997-08-19 | Desai; Jawahar M. | Apparatus and method for cardiac ablation |
US5840031A (en) | 1993-07-01 | 1998-11-24 | Boston Scientific Corporation | Catheters for imaging, sensing electrical potentials and ablating tissue |
IL116699A (en) | 1996-01-08 | 2001-09-13 | Biosense Ltd | Method of constructing cardiac map |
US5738096A (en) | 1993-07-20 | 1998-04-14 | Biosense, Inc. | Cardiac electromechanics |
WO1996005768A1 (en) | 1994-08-19 | 1996-02-29 | Biosense, Inc. | Medical diagnosis, treatment and imaging systems |
US5391199A (en) | 1993-07-20 | 1995-02-21 | Biosense, Inc. | Apparatus and method for treating cardiac arrhythmias |
US5409000A (en) | 1993-09-14 | 1995-04-25 | Cardiac Pathways Corporation | Endocardial mapping and ablation system utilizing separately controlled steerable ablation catheter with ultrasonic imaging capabilities and method |
WO1995009561A1 (en) | 1993-10-01 | 1995-04-13 | Target Therapeutics, Inc. | Sheathed multipolar catheter and multipolar guidewire for sensing cardiac electrical activity |
WO1995010225A1 (en) | 1993-10-15 | 1995-04-20 | Ep Technologies, Inc. | Multiple electrode element for mapping and ablating |
US5454370A (en) | 1993-12-03 | 1995-10-03 | Avitall; Boaz | Mapping and ablation electrode configuration |
US5730127A (en) | 1993-12-03 | 1998-03-24 | Avitall; Boaz | Mapping and ablation catheter system |
US5921924A (en) | 1993-12-03 | 1999-07-13 | Avitall; Boaz | Mapping and ablation catheter system utilizing multiple control elements |
US5531227A (en) | 1994-01-28 | 1996-07-02 | Schneider Medical Technologies, Inc. | Imaging device and method |
US5487391A (en) | 1994-01-28 | 1996-01-30 | Ep Technologies, Inc. | Systems and methods for deriving and displaying the propagation velocities of electrical events in the heart |
US5485849A (en) | 1994-01-31 | 1996-01-23 | Ep Technologies, Inc. | System and methods for matching electrical characteristics and propagation velocities in cardiac tissue |
US5595183A (en) | 1995-02-17 | 1997-01-21 | Ep Technologies, Inc. | Systems and methods for examining heart tissue employing multiple electrode structures and roving electrodes |
US5515853A (en) | 1995-03-28 | 1996-05-14 | Sonometrics Corporation | Three-dimensional digital ultrasound tracking system |
US5718241A (en) | 1995-06-07 | 1998-02-17 | Biosense, Inc. | Apparatus and method for treating cardiac arrhythmias with no discrete target |
AU6178696A (en) * | 1995-06-16 | 1997-01-15 | Trustees Of The University Of Pennsylvania, The | Apparatus and method for dynamic modeling of an object |
US5889524A (en) | 1995-09-11 | 1999-03-30 | University Of Washington | Reconstruction of three-dimensional objects using labeled piecewise smooth subdivision surfaces |
US5697377A (en) | 1995-11-22 | 1997-12-16 | Medtronic, Inc. | Catheter mapping system and method |
US5837001A (en) | 1995-12-08 | 1998-11-17 | C. R. Bard | Radio frequency energy delivery system for multipolar electrode catheters |
DE69728257T2 (en) | 1996-01-08 | 2005-03-10 | Biosense Inc. | DEVICE FOR MYOCARDIAL VASCULATION |
DE69726599T2 (en) | 1996-01-08 | 2004-09-30 | Biosense Inc. | ELECTROMECHANICAL HEART DEVICE |
US5769843A (en) * | 1996-02-20 | 1998-06-23 | Cormedica | Percutaneous endomyocardial revascularization |
US5755664A (en) | 1996-07-11 | 1998-05-26 | Arch Development Corporation | Wavefront direction mapping catheter system |
US5951571A (en) | 1996-09-19 | 1999-09-14 | Surgical Navigation Specialist Inc. | Method and apparatus for correlating a body with an image of the body |
IL126491A (en) | 1997-02-14 | 2004-01-04 | Biosense Inc | X-ray guided surgical location system with extended mapping volume |
JP3660781B2 (en) * | 1997-05-26 | 2005-06-15 | 株式会社東芝 | Diagnostic device for intracardiac electrical phenomena |
US5999587A (en) | 1997-07-03 | 1999-12-07 | University Of Rochester | Method of and system for cone-beam tomography reconstruction |
SE9702678D0 (en) | 1997-07-11 | 1997-07-11 | Siemens Elema Ab | Device for mapping electrical activity in the heart |
US6490474B1 (en) | 1997-08-01 | 2002-12-03 | Cardiac Pathways Corporation | System and method for electrode localization using ultrasound |
JP4208275B2 (en) * | 1997-10-30 | 2009-01-14 | 株式会社東芝 | Diagnostic device for intracardiac electrical phenomenon and method for displaying the phenomenon |
US5931863A (en) | 1997-12-22 | 1999-08-03 | Procath Corporation | Electrophysiology catheter |
JPH11197159A (en) * | 1998-01-13 | 1999-07-27 | Hitachi Ltd | Operation supporting system |
AU743966B2 (en) * | 1998-01-22 | 2002-02-14 | Biosense, Inc. | Intrabody measurement |
US6226542B1 (en) | 1998-07-24 | 2001-05-01 | Biosense, Inc. | Three-dimensional reconstruction of intrabody organs |
US6950689B1 (en) | 1998-08-03 | 2005-09-27 | Boston Scientific Scimed, Inc. | Dynamically alterable three-dimensional graphical model of a body region |
JP2002526188A (en) * | 1998-09-24 | 2002-08-20 | スーパー ディメンション リミテッド | System and method for determining the position of a catheter during a medical procedure inside the body |
US6389310B1 (en) * | 1999-03-02 | 2002-05-14 | Georges Demonceau | Method and apparatus for analyzing heart function using 4D ECG synchronized heart cavity tomoscintigraphy |
US6892091B1 (en) | 2000-02-18 | 2005-05-10 | Biosense, Inc. | Catheter, method and apparatus for generating an electrical map of a chamber of the heart |
US10982098B2 (en) | 2017-11-30 | 2021-04-20 | The Regents Of The University Of California | Compositions and methods for the modification of imine covalent organic frameworks (COFs) |
-
2000
- 2000-08-18 US US09/643,666 patent/US6650927B1/en not_active Expired - Lifetime
-
2001
- 2001-08-14 IL IL144905A patent/IL144905A/en active IP Right Grant
- 2001-08-15 AU AU59877/01A patent/AU782242B2/en not_active Expired
- 2001-08-16 CA CA2355397A patent/CA2355397C/en not_active Expired - Lifetime
- 2001-08-17 EP EP01307001.6A patent/EP1182619B1/en not_active Expired - Lifetime
- 2001-08-17 ES ES01307001.6T patent/ES2557152T3/en not_active Expired - Lifetime
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- 2001-08-17 KR KR1020010049501A patent/KR100819717B1/en not_active IP Right Cessation
- 2001-08-20 JP JP2001249066A patent/JP5088994B2/en not_active Expired - Lifetime
-
2002
- 2002-05-30 HK HK02104029.5A patent/HK1042366A1/en unknown
Also Published As
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IL144905A (en) | 2006-10-31 |
EP2942756A3 (en) | 2016-01-27 |
CA2355397A1 (en) | 2002-02-18 |
AU782242B2 (en) | 2005-07-14 |
KR100819717B1 (en) | 2008-04-07 |
ES2557152T3 (en) | 2016-01-22 |
US6650927B1 (en) | 2003-11-18 |
EP1182619A2 (en) | 2002-02-27 |
HK1042366A1 (en) | 2002-08-09 |
EP1182619A3 (en) | 2004-09-29 |
AU5987701A (en) | 2002-02-21 |
EP2942756A2 (en) | 2015-11-11 |
KR20020014751A (en) | 2002-02-25 |
IL144905A0 (en) | 2002-06-30 |
JP5088994B2 (en) | 2012-12-05 |
EP1182619B1 (en) | 2015-09-23 |
JP2002143179A (en) | 2002-05-21 |
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