CA2343401A1 - Multi-modal optical tissue diagnostic system - Google Patents

Multi-modal optical tissue diagnostic system Download PDF

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Publication number
CA2343401A1
CA2343401A1 CA002343401A CA2343401A CA2343401A1 CA 2343401 A1 CA2343401 A1 CA 2343401A1 CA 002343401 A CA002343401 A CA 002343401A CA 2343401 A CA2343401 A CA 2343401A CA 2343401 A1 CA2343401 A1 CA 2343401A1
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CA
Canada
Prior art keywords
tissue
target tissue
diagnostic system
electromagnetic radiation
optical tissue
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA002343401A
Other languages
French (fr)
Other versions
CA2343401C (en
Inventor
Shabbir B. Bambot
Mark L. Faupel
Tim Harrell
Anant Agrawal
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Spectrx Inc
Original Assignee
Spectrx, Inc.
Shabbir B. Bambot
Mark L. Faupel
Tim Harrell
Anant Agrawal
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Spectrx, Inc., Shabbir B. Bambot, Mark L. Faupel, Tim Harrell, Anant Agrawal filed Critical Spectrx, Inc.
Publication of CA2343401A1 publication Critical patent/CA2343401A1/en
Application granted granted Critical
Publication of CA2343401C publication Critical patent/CA2343401C/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/0059—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence
    • A61B5/0071—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence by measuring fluorescence emission
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/0059—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence
    • A61B5/0075—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence by spectroscopy, i.e. measuring spectra, e.g. Raman spectroscopy, infrared absorption spectroscopy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/0059—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence
    • A61B5/0082—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence adapted for particular medical purposes
    • A61B5/0084—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence adapted for particular medical purposes for introduction into the body, e.g. by catheters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B1/00—Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor
    • A61B1/04—Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor combined with photographic or television appliances
    • A61B1/043—Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor combined with photographic or television appliances for fluorescence imaging
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/72—Signal processing specially adapted for physiological signals or for diagnostic purposes
    • A61B5/7235—Details of waveform analysis
    • A61B5/7264—Classification of physiological signals or data, e.g. using neural networks, statistical classifiers, expert systems or fuzzy systems

Abstract

The methods and apparatus according to the invention combine more than one optical modality, including but not limited to, fluorescence, absorption, reflectance, polarization anisotropy, and phase modulation to decouple morphological, biochemical changes associated with tissue changes, thus to provide an accurate diagnosis of the tissue's condition. The apparatus includes a transmit optical fiber bundle (52) to illuminate a target tissue, and optical fibers (54) to receive electromagnetic radiation returned from the target tissue.
The processor device (44) analyzes the returned electromagnetic radiation to determine characteristics of the target tissue.
CA002343401A 1998-09-11 1999-09-10 Multi-modal optical tissue diagnostic system Expired - Lifetime CA2343401C (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US9987598P 1998-09-11 1998-09-11
US60/099,875 1998-09-11
US14357999P 1999-07-13 1999-07-13
US60/143,579 1999-07-13
PCT/US1999/020646 WO2000015101A1 (en) 1998-09-11 1999-09-10 Multi-modal optical tissue diagnostic system

Publications (2)

Publication Number Publication Date
CA2343401A1 true CA2343401A1 (en) 2000-03-23
CA2343401C CA2343401C (en) 2009-01-27

Family

ID=26796580

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002343401A Expired - Lifetime CA2343401C (en) 1998-09-11 1999-09-10 Multi-modal optical tissue diagnostic system

Country Status (7)

Country Link
US (2) US6975899B2 (en)
EP (1) EP1112022A4 (en)
JP (1) JP4474050B2 (en)
AU (1) AU6139199A (en)
CA (1) CA2343401C (en)
IL (1) IL141864A0 (en)
WO (1) WO2000015101A1 (en)

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* Cited by examiner, † Cited by third party
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