CA2340657A1 - Multi-channel capillary electrophoresis device including sheath-flow cuvette and replaceable capillary array - Google Patents

Multi-channel capillary electrophoresis device including sheath-flow cuvette and replaceable capillary array Download PDF

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Publication number
CA2340657A1
CA2340657A1 CA002340657A CA2340657A CA2340657A1 CA 2340657 A1 CA2340657 A1 CA 2340657A1 CA 002340657 A CA002340657 A CA 002340657A CA 2340657 A CA2340657 A CA 2340657A CA 2340657 A1 CA2340657 A1 CA 2340657A1
Authority
CA
Canada
Prior art keywords
capillary
channel
receiving slot
gap region
device including
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA002340657A
Other languages
French (fr)
Other versions
CA2340657C (en
Inventor
Eric S. Nordman
John Shigeura
Albert L. Carrillo
David M. Demorest
Philip J. Wunderle
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Applied Biosystems LLC
Original Assignee
Pe Corporation (Ny)
Eric S. Nordman
John Shigeura
Albert L. Carrillo
David M. Demorest
Philip J. Wunderle
The Perkin-Elmer Corporation
Applera Corporation
Applied Biosystems Inc.
Applied Biosystems, Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pe Corporation (Ny), Eric S. Nordman, John Shigeura, Albert L. Carrillo, David M. Demorest, Philip J. Wunderle, The Perkin-Elmer Corporation, Applera Corporation, Applied Biosystems Inc., Applied Biosystems, Llc filed Critical Pe Corporation (Ny)
Publication of CA2340657A1 publication Critical patent/CA2340657A1/en
Application granted granted Critical
Publication of CA2340657C publication Critical patent/CA2340657C/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
    • G01N27/26—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
    • G01N27/416—Systems
    • G01N27/447—Systems using electrophoresis
    • G01N27/44756—Apparatus specially adapted therefor
    • G01N27/44782—Apparatus specially adapted therefor of a plurality of samples
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N2035/00178—Special arrangements of analysers
    • G01N2035/00237—Handling microquantities of analyte, e.g. microvalves, capillary networks

Abstract

A multi-channel capillary electrophoresis apparatus is disclosed. The apparatus includes a capillary array assembly comprising a plurality of capillaries, each capillary having a capillary outlet, and an outlet support for supporting the capillary outlets.
The apparatus further includes a cuvette defining a receiving slot, a gap region, and a detection zone, where the receiving slot is adapted to removably receive the outlet support, and wherein when the outlet support is inserted into the receiving slot, the capillary outlets are positioned in the gap region in proximity to the detection zone, and a flow channel is formed by the outlet support and the receiving slot such that the flow channel is in fluid communication with the gap region. In addition, the apparatus includes a front plumbing block in fluid communication with the flow channel for supplying a fluid flow through the gap region sufficient to transport material downstream from the capillary outlets to the detection zone.
CA002340657A 1998-09-11 1999-09-09 Multi-channel capillary electrophoresis device including sheath-flow cuvette and replaceable capillary array Expired - Fee Related CA2340657C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US09/151,928 1998-09-11
US09/151,928 US6162341A (en) 1998-09-11 1998-09-11 Multi-channel capillary electrophoresis device including sheath-flow cuvette and replacable capillary array
PCT/US1999/020630 WO2000016086A1 (en) 1998-09-11 1999-09-09 Multi-channel capillary electrophoresis device including sheath-flow cuvette and replaceable capillary array

Publications (2)

Publication Number Publication Date
CA2340657A1 true CA2340657A1 (en) 2000-03-23
CA2340657C CA2340657C (en) 2005-01-11

Family

ID=22540848

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002340657A Expired - Fee Related CA2340657C (en) 1998-09-11 1999-09-09 Multi-channel capillary electrophoresis device including sheath-flow cuvette and replaceable capillary array

Country Status (8)

Country Link
US (4) US6162341A (en)
EP (2) EP1178306B1 (en)
JP (2) JP3690985B2 (en)
AT (2) ATE232297T1 (en)
AU (1) AU757186B2 (en)
CA (1) CA2340657C (en)
DE (2) DE69932641T2 (en)
WO (1) WO2000016086A1 (en)

Families Citing this family (55)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6365024B1 (en) * 1997-06-30 2002-04-02 Spectrumedix Corporation Motorized positioning apparatus having coaxial carrousels
EP0984276A4 (en) * 1998-02-16 2003-08-27 Inst Physical & Chem Res Capillary cassette and method of producing the same
EP0955084B1 (en) * 1998-04-27 2006-07-26 Corning Incorporated Method of depositing an array of biological samples using a redrawn capillary reservoir
US6884626B1 (en) 1998-04-27 2005-04-26 Corning Incorporated Redrawn capillary imaging reservoir
US6762061B1 (en) 1998-07-03 2004-07-13 Corning Incorporated Redrawn capillary imaging reservoir
SE9802558D0 (en) 1998-07-16 1998-07-16 Hanning Instr Ab Device for detection of fluorescent
US6162341A (en) * 1998-09-11 2000-12-19 The Perkin-Elmer Corporation Multi-channel capillary electrophoresis device including sheath-flow cuvette and replacable capillary array
US20020006359A1 (en) * 1998-11-25 2002-01-17 Affymetrix, Inc. Microplate sample and reagent loading system
US6627157B1 (en) * 1999-03-04 2003-09-30 Ut-Battelle, Llc Dual manifold system and method for fluid transfer
JP4159702B2 (en) * 1999-05-12 2008-10-01 独立行政法人理化学研究所 Gel packing device for capillary column
CA2391758C (en) * 1999-08-13 2010-02-16 Cartesian Technologies, Inc. Apparatus for liquid sample handling
US20020028160A1 (en) * 2000-02-22 2002-03-07 Jianming Xiao Method and apparatus based on bundled capillaries for high throughput screening
US6918309B2 (en) * 2001-01-17 2005-07-19 Irm Llc Sample deposition method and system
US6797139B2 (en) 2001-03-19 2004-09-28 Applera Corporation Detection cell for guiding excitation light therein and method for using same
JP3897277B2 (en) * 2001-04-02 2007-03-22 株式会社日立製作所 Capillary array and capillary array photodetector
EP1323474A1 (en) * 2001-12-31 2003-07-02 Corning Incorporated Device and process for simultaneous transfer of liquids
US20030196896A1 (en) * 2002-04-17 2003-10-23 Mcwaid Thomas Harding Method and apparatus for screening flowable separation media for electrophoresis and related applications
JP4038386B2 (en) * 2002-04-26 2008-01-23 株式会社日立ハイテクノロジーズ Capillary array and electrophoresis apparatus
US6758835B2 (en) 2002-05-01 2004-07-06 Medtg, Llc Disposable needle assembly having sensors formed therein permitting the simultaneous drawing and administering of fluids and method of forming the same
JP2003337117A (en) * 2002-05-17 2003-11-28 Hitachi High-Technologies Corp Capillary array and method for manufacturing the same
US7108775B2 (en) * 2002-11-08 2006-09-19 Applera Corporation Apparatus and method for confining eluted samples in electrophoresis systems
US7025935B2 (en) * 2003-04-11 2006-04-11 Illumina, Inc. Apparatus and methods for reformatting liquid samples
EP1677886A1 (en) * 2003-09-30 2006-07-12 Chromba, Inc. Multicapillary column for chromatography and sample preparation
US20050133371A1 (en) * 2003-09-30 2005-06-23 West Virginia University Research Corporation Apparatus and method for Edman degradation on a microfluidic device utilizing an electroosmotic flow pump
US20070017870A1 (en) 2003-09-30 2007-01-25 Belov Yuri P Multicapillary device for sample preparation
DE20315371U1 (en) * 2003-10-02 2005-02-17 Thinxxs Gmbh Connector for use with e.g. miniaturized liquid cells in chemical, medical and biological analysis and synthesis has longitudinal connecting channel and is less rigid in direction of its thickness than at right angles to it
RU2252411C1 (en) * 2004-04-09 2005-05-20 Общество с ограниченной ответственностью "Институт рентгеновской оптики" Fluorescent sensor on basis of multichannel structures
US7258776B2 (en) * 2004-07-08 2007-08-21 Applera Corporation Capillary array assembly for loading samples from a device, and method
US20060013981A1 (en) * 2004-07-19 2006-01-19 University Of South Florida Polytetrahydrofuran-Based Coating for Capillary Microextraction
US7846676B2 (en) 2004-07-19 2010-12-07 Cell Biosciences, Inc. Methods and devices for analyte detection
US7935479B2 (en) 2004-07-19 2011-05-03 Cell Biosciences, Inc. Methods and devices for analyte detection
JP4474257B2 (en) * 2004-10-07 2010-06-02 株式会社日立ハイテクノロジーズ Electrophoresis device
JP4512465B2 (en) * 2004-10-13 2010-07-28 株式会社日立ハイテクノロジーズ Electrophoresis device
US8021611B2 (en) * 2005-04-09 2011-09-20 ProteinSimple Automated micro-volume assay system
JP3116709U (en) * 2005-09-13 2005-12-15 有限会社メタボスクリーン Microchannel chip
US20070059208A1 (en) * 2005-09-14 2007-03-15 Applera Corporation Fluid processing device and integration with sample preparation processes
WO2007035864A2 (en) * 2005-09-20 2007-03-29 Cell Biosciences, Inc. Electrophoresis standards, methods and kits
US20070209938A1 (en) * 2006-03-13 2007-09-13 Jianzhong Zhang Method and apparatus for biopolymer analysis
US20070224088A1 (en) * 2006-03-24 2007-09-27 Applera Corporation Fluid processing device including output interface with analyzer
JP4384160B2 (en) * 2006-10-16 2009-12-16 株式会社日立ハイテクノロジーズ Capillary array and electrophoresis apparatus
JP4577322B2 (en) * 2007-03-26 2010-11-10 株式会社日立製作所 Capillary array and cap set
US20110092686A1 (en) * 2008-03-28 2011-04-21 Pelican Group Holdings, Inc. Multicapillary sample preparation devices and methods for processing analytes
US20090250345A1 (en) * 2008-04-03 2009-10-08 Protea Biosciences, Inc. Microfluidic electroelution devices & processes
US20090250347A1 (en) * 2008-04-03 2009-10-08 Protea Biosciences, Inc. Microfluidic devices & processes for electrokinetic transport
US8233146B2 (en) * 2009-01-13 2012-07-31 Becton, Dickinson And Company Cuvette for flow-type particle analyzer
WO2011106098A2 (en) * 2010-02-25 2011-09-01 Advanced Microlabs, Llc Microfluidic interface for a microchip
EP2688399B1 (en) 2011-03-24 2015-11-04 Enviro Tech Chemical Services Inc. Methods and compositions for the generation of peracetic acid on site at the point-of-use
US8546449B2 (en) 2011-03-24 2013-10-01 Enviro Tech Chemical Services, Inc. Methods and compositions for the generation of peracetic acid on site at the point-of-use
JP2014526047A (en) * 2011-08-05 2014-10-02 ワイアット テクノロジー コーポレイション Bubble suppression system for optical measurement cell
GB201116859D0 (en) * 2011-09-30 2011-11-09 Ge Healthcare Ltd Flow cell
CN102539512B (en) * 2012-02-10 2014-02-26 上海康盈生物科技有限公司 Multichannel capillary electrophoresis method for detecting glycosylated hemoglobin HbA1c in multiple samples simultaneously
DK2938369T3 (en) 2012-12-31 2018-08-06 Medtg Llc INFUSION AND BLOOD COLLECTION DEVICE
DE102016015700A1 (en) 2016-12-21 2018-06-21 Bayer Pharma Aktiengesellschaft metering
CN110487764A (en) * 2019-08-30 2019-11-22 天津陆海石油设备系统工程有限责任公司 The hand automatic sampling mode switching device of quantitative fluorescence analysis instrument
US11642458B2 (en) 2019-11-26 2023-05-09 Medtg, Llc Infusion and blood collection devices and methods

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3559813A (en) * 1968-08-02 1971-02-02 Thomas & Betts Corp Module mounting system
US4811218A (en) * 1986-06-02 1989-03-07 Applied Biosystems, Inc. Real time scanning electrophoresis apparatus for DNA sequencing
US5274240A (en) * 1990-01-12 1993-12-28 The Regents Of The University Of California Capillary array confocal fluorescence scanner and method
US5516409A (en) * 1991-02-28 1996-05-14 Hitachi, Ltd. DNA detector and DNA detection method
JP2785530B2 (en) 1991-09-13 1998-08-13 株式会社日立製作所 Electrophoresis device
US5605666A (en) * 1993-04-16 1997-02-25 Beckman Instruments, Inc. Capillary retaining system
JP3563140B2 (en) * 1995-01-19 2004-09-08 株式会社日立製作所 Capillary array electrophoresis device
US5730850A (en) * 1993-04-23 1998-03-24 Hitachi, Ltd. Capillary array electrophoresis system
US5439578A (en) * 1993-06-03 1995-08-08 The Governors Of The University Of Alberta Multiple capillary biochemical analyzer
US5790727A (en) * 1997-02-05 1998-08-04 Brookhaven Science Associates Llc Laser illumination of multiple capillaries that form a waveguide
JPH10239278A (en) * 1997-02-24 1998-09-11 Hitachi Ltd Cataphoresis device
US6054032A (en) * 1998-01-27 2000-04-25 3M Innovative Properties Company Capillary electrophoresis array
US6162341A (en) * 1998-09-11 2000-12-19 The Perkin-Elmer Corporation Multi-channel capillary electrophoresis device including sheath-flow cuvette and replacable capillary array

Also Published As

Publication number Publication date
AU5817699A (en) 2000-04-03
US20010019019A1 (en) 2001-09-06
ATE232297T1 (en) 2003-02-15
DE69932641T2 (en) 2007-07-26
US6162341A (en) 2000-12-19
JP2002525575A (en) 2002-08-13
JP3690985B2 (en) 2005-08-31
US6387236B2 (en) 2002-05-14
DE69905257T2 (en) 2003-11-27
EP1110080A1 (en) 2001-06-27
US20020029972A1 (en) 2002-03-14
DE69905257D1 (en) 2003-03-13
AU757186B2 (en) 2003-02-06
WO2000016086A1 (en) 2000-03-23
EP1178306B1 (en) 2006-08-02
ATE335197T1 (en) 2006-08-15
EP1178306A2 (en) 2002-02-06
CA2340657C (en) 2005-01-11
DE69932641D1 (en) 2006-09-14
EP1110080B1 (en) 2003-02-05
EP1178306A3 (en) 2002-11-06
JP2005241655A (en) 2005-09-08
US6231739B1 (en) 2001-05-15
JP4138767B2 (en) 2008-08-27

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