CA2339992A1 - Orally disintegrable tablet forming a viscous slurry - Google Patents

Orally disintegrable tablet forming a viscous slurry Download PDF

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Publication number
CA2339992A1
CA2339992A1 CA002339992A CA2339992A CA2339992A1 CA 2339992 A1 CA2339992 A1 CA 2339992A1 CA 002339992 A CA002339992 A CA 002339992A CA 2339992 A CA2339992 A CA 2339992A CA 2339992 A1 CA2339992 A1 CA 2339992A1
Authority
CA
Canada
Prior art keywords
viscous slurry
tablet forming
orally disintegrable
disintegrable tablet
mouth
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA002339992A
Other languages
French (fr)
Other versions
CA2339992C (en
Inventor
John M. Siebert
Rajendra K. Khankari
Unchalee Kositprapa
S. Indiran Pather
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Cima Labs Inc
Original Assignee
Cima Labs Inc.
John M. Siebert
Rajendra K. Khankari
Unchalee Kositprapa
S. Indiran Pather
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cima Labs Inc., John M. Siebert, Rajendra K. Khankari, Unchalee Kositprapa, S. Indiran Pather filed Critical Cima Labs Inc.
Publication of CA2339992A1 publication Critical patent/CA2339992A1/en
Application granted granted Critical
Publication of CA2339992C publication Critical patent/CA2339992C/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0002—Galenical forms characterised by the drug release technique; Application systems commanded by energy
    • A61K9/0007—Effervescent
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A61K9/0056—Mouth soluble or dispersible forms; Suckable, eatable, chewable coherent forms; Forms rapidly disintegrating in the mouth; Lozenges; Lollipops; Bite capsules; Baked products; Baits or other oral forms for animals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2009—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
    • A61K9/2077—Tablets comprising drug-containing microparticles in a substantial amount of supporting matrix; Multiparticulate tablets
    • A61K9/2081—Tablets comprising drug-containing microparticles in a substantial amount of supporting matrix; Multiparticulate tablets with microcapsules or coated microparticles according to A61K9/50
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5005—Wall or coating material
    • A61K9/5021—Organic macromolecular compounds
    • A61K9/5036—Polysaccharides, e.g. gums, alginate; Cyclodextrin
    • A61K9/5042—Cellulose; Cellulose derivatives, e.g. phthalate or acetate succinate esters of hydroxypropyl methylcellulose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5005—Wall or coating material
    • A61K9/5021—Organic macromolecular compounds
    • A61K9/5036—Polysaccharides, e.g. gums, alginate; Cyclodextrin
    • A61K9/5042—Cellulose; Cellulose derivatives, e.g. phthalate or acetate succinate esters of hydroxypropyl methylcellulose
    • A61K9/5047—Cellulose ethers containing no ester groups, e.g. hydroxypropyl methylcellulose

Abstract

A dosage form which rapidly disintegrates in the mouth and forms a viscous slurry of either microcapsules or a powder is described. The rapidly disintegrating dosage form is meant for direct oral administration by placing a tablet or capsule in the mouth of a patient. Upon disintegration, a viscosity of the resulting slurry increases so as to form an organoleptically pleasant viscous material which retards the spread of insoluble materials including the drug.
CA002339992A 1998-08-12 1999-08-12 Orally disintegrable tablet forming a viscous slurry Expired - Fee Related CA2339992C (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US9626598P 1998-08-12 1998-08-12
US60/096,265 1998-08-12
US09/372,738 1999-08-11
US09/372,738 US6368625B1 (en) 1998-08-12 1999-08-11 Orally disintegrable tablet forming a viscous slurry
PCT/US1999/018400 WO2000009090A1 (en) 1998-08-12 1999-08-12 Orally disintegrable tablet forming a viscous slurry

Publications (2)

Publication Number Publication Date
CA2339992A1 true CA2339992A1 (en) 2000-02-24
CA2339992C CA2339992C (en) 2006-01-03

Family

ID=26791503

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002339992A Expired - Fee Related CA2339992C (en) 1998-08-12 1999-08-12 Orally disintegrable tablet forming a viscous slurry

Country Status (9)

Country Link
US (1) US6368625B1 (en)
EP (1) EP1104288B1 (en)
JP (1) JP2002522471A (en)
AT (1) ATE326951T1 (en)
AU (1) AU742049B2 (en)
CA (1) CA2339992C (en)
DE (1) DE69931498T2 (en)
ES (1) ES2265188T3 (en)
WO (1) WO2000009090A1 (en)

Families Citing this family (91)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8071128B2 (en) 1996-06-14 2011-12-06 Kyowa Hakko Kirin Co., Ltd. Intrabuccally rapidly disintegrating tablet and a production method of the tablets
US7727552B1 (en) 1997-03-28 2010-06-01 Eisai R&D Management Co., Ltd. Oral pharmaceutical preparations decreased in bitterness by masking
US20030118645A1 (en) * 1998-04-29 2003-06-26 Pather S. Indiran Pharmaceutical compositions for rectal and vaginal administration
US6974590B2 (en) * 1998-03-27 2005-12-13 Cima Labs Inc. Sublingual buccal effervescent
US20030091629A1 (en) * 1998-03-27 2003-05-15 Cima Labs Inc. Sublingual buccal effervescent
SE9802973D0 (en) 1998-09-03 1998-09-03 Astra Ab Immediate release tablet
US10179130B2 (en) 1999-10-29 2019-01-15 Purdue Pharma L.P. Controlled release hydrocodone formulations
EP2295043A1 (en) 1999-10-29 2011-03-16 Euro-Celtique S.A. Controlled release hydrocodone formulations
ES2327898T3 (en) * 2000-03-01 2009-11-05 EISAI R&D MANAGEMENT CO., LTD. RAPID DISINTEGRATION TABLET CONTAINING POLI (VINYL ALCOHOL).
JP4698000B2 (en) * 2000-06-27 2011-06-08 旭化成ケミカルズ株式会社 Easily water-soluble drug-containing tablets
KR101167465B1 (en) 2000-10-30 2012-07-27 유로-셀티크 소시에떼 아노뉨 Controlled release hydrocodone formulations
US7799342B2 (en) * 2000-12-06 2010-09-21 Wyeth Llc Fast dissolving tablet
US9358214B2 (en) 2001-10-04 2016-06-07 Adare Pharmaceuticals, Inc. Timed, sustained release systems for propranolol
AU2002302890A1 (en) * 2002-02-04 2003-12-02 Ranbaxy Laboratories Limited Hydrodynamically balancing oral drug delivery system with biphasic release
GB0203984D0 (en) * 2002-02-20 2002-04-03 Mach Ind Etablissements Comsumable container
SI21221A (en) * 2002-06-21 2003-12-31 LEK, tovarna farmacevtskih in kemi�nih izdelkov, d.d. Quickly decomposable tablets
GB0217056D0 (en) * 2002-07-23 2002-08-28 Ass Octel Use
DE10244504A1 (en) * 2002-09-25 2004-04-08 Capsulution Nanoscience Ag Quick-release dosage form with poorly soluble active ingredient
US8367111B2 (en) * 2002-12-31 2013-02-05 Aptalis Pharmatech, Inc. Extended release dosage forms of propranolol hydrochloride
WO2004066924A2 (en) * 2003-01-24 2004-08-12 Andrx Labs Llc Novel pharmaceutical formulation containing a proton pump inhibitor and an antacid
DE10311585A1 (en) * 2003-03-14 2004-09-23 Basf Ag Adsorbates for use in human or animal nutrition or cosmetics are produced by introducing material to be adsorbed together with stabilizer on to carrier
MXPA05009886A (en) * 2003-03-14 2006-05-04 Nirmal Mulye A process for preparing sustained release tablets.
WO2004098571A1 (en) * 2003-04-30 2004-11-18 Zicam, Llc Cold remedy composition comprising zinc salts
CN1819819B (en) 2003-05-07 2011-03-09 株式会社三养社 Highly plastic granules for making fast melting tablets
US20040265372A1 (en) * 2003-06-27 2004-12-30 David Wynn Soft tablet containing high molecular weight cellulosics
US20040265373A1 (en) * 2003-06-27 2004-12-30 David Wynn Soft tablet containing high molecular weight cellulosics
CA2531637A1 (en) * 2003-07-23 2005-02-03 L. Perrigo Company Cellulosic fiber containing composition
US7390503B1 (en) 2003-08-22 2008-06-24 Barr Laboratories, Inc. Ondansetron orally disintegrating tablets
JP4740740B2 (en) * 2003-12-09 2011-08-03 大日本住友製薬株式会社 Drug-containing particles and solid preparation containing the particles
WO2005065317A2 (en) * 2003-12-31 2005-07-21 Cima Labs Inc. Effervescent oral fentanyl dosage form
US20070036853A1 (en) * 2003-12-31 2007-02-15 Cima Labs Inc. Generally linear effervescent oral fentanyl dosage form and methods of administering
BRPI0418228B8 (en) * 2003-12-31 2021-05-25 Cima Labs Inc dosage form, and method of preparing a tablet for buccal, gingival or sublingual administration of fentanyl
EP1708685B1 (en) * 2003-12-31 2011-03-09 Cima Labs Inc. Effervescent oral opiate dosage forms and methods of administering oxycodone
WO2005074658A2 (en) * 2004-01-30 2005-08-18 Glenmark Pharmaceuticals Inc., Usa Carbonyl iron pharmaceutical dosage forms for the treatment of iron-deficiency anemia
US20050170014A1 (en) * 2004-01-30 2005-08-04 Anandi Krishnan Carbonyl iron pharmaceutical dosage forms for the treatment of iron-deficiency anemia
KR20130006523A (en) * 2004-02-17 2013-01-16 트랜스셉트 파마슈티칼스, 인코포레이티드 Compositions for delivering hypnotic agents across the oral mucosa and methods of use thereof
US20060003003A1 (en) * 2004-06-28 2006-01-05 Bakker Johan A Oral sustained release formulation of tedisamil with gastric retention properties
US8747895B2 (en) * 2004-09-13 2014-06-10 Aptalis Pharmatech, Inc. Orally disintegrating tablets of atomoxetine
US8252321B2 (en) 2004-09-13 2012-08-28 Chrono Therapeutics, Inc. Biosynchronous transdermal drug delivery for longevity, anti-aging, fatigue management, obesity, weight loss, weight management, delivery of nutraceuticals, and the treatment of hyperglycemia, alzheimer's disease, sleep disorders, parkinson's disease, aids, epilepsy, attention deficit disorder, nicotine addiction, cancer, headache and pain control, asthma, angina, hypertension, depression, cold, flu and the like
JP5254616B2 (en) 2004-09-13 2013-08-07 クロノ セラピューティクス、インコーポレイテッド Biosynchronous transdermal drug delivery
US9884014B2 (en) 2004-10-12 2018-02-06 Adare Pharmaceuticals, Inc. Taste-masked pharmaceutical compositions
EP1802285B1 (en) 2004-10-21 2013-02-27 Aptalis Pharmatech, Inc. Taste-masked pharmaceutical compositions with gastrosoluble pore-formers
US20060105038A1 (en) * 2004-11-12 2006-05-18 Eurand Pharmaceuticals Limited Taste-masked pharmaceutical compositions prepared by coacervation
EP1830814B1 (en) * 2005-01-06 2009-07-01 Cima Labs Inc. Taste masking system for non-plasticizing drugs
US9161918B2 (en) 2005-05-02 2015-10-20 Adare Pharmaceuticals, Inc. Timed, pulsatile release systems
US20070287740A1 (en) 2005-05-25 2007-12-13 Transcept Pharmaceuticals, Inc. Compositions and methods of treating middle-of-the night insomnia
KR20080031208A (en) * 2005-05-25 2008-04-08 트랜스셉트 파마슈티칼스, 인코포레이티드 Solid compositions and methods for treating middle-of-the night insomnia
US20070225322A1 (en) * 2005-05-25 2007-09-27 Transoral Pharmaceuticals, Inc. Compositions and methods for treating middle-of-the night insomnia
WO2014007972A2 (en) 2012-06-15 2014-01-09 Nova Southeastern University Epinephrine nanoparticles, methods of fabrication thereof, and methods for use thereof for treatment of conditions responsive to epinphrine
US9877921B2 (en) 2005-09-09 2018-01-30 Nova Southeastern University Epinephrine nanoparticles, methods of fabrication thereof, and methods for use thereof for treatment of conditions responsive to epinephrine
US20070059361A1 (en) * 2005-09-09 2007-03-15 University Of Manitoba Fast-disintegrating epinephrine tablets for buccal or sublingual administration
US20160045457A1 (en) 2005-09-09 2016-02-18 Ousama Rachid Epinephrine fine particles and methods for use thereof for treatment of conditions responsive to epinephrine
AU2006311826C1 (en) * 2005-11-03 2011-06-16 Redpoint Bio Corporation Hydrazone derivatives and uses thereof
US8497258B2 (en) 2005-11-12 2013-07-30 The Regents Of The University Of California Viscous budesonide for the treatment of inflammatory diseases of the gastrointestinal tract
US7811604B1 (en) 2005-11-14 2010-10-12 Barr Laboratories, Inc. Non-effervescent, orally disintegrating solid pharmaceutical dosage forms comprising clozapine and methods of making and using the same
US7427414B2 (en) * 2006-01-18 2008-09-23 Astron Research Limited Modified release oral dosage form using co-polymer of polyvinyl acetate
US20070281014A1 (en) * 2006-06-01 2007-12-06 Cima Labs, Inc. Prednisolone salt formulations
WO2007143674A2 (en) * 2006-06-05 2007-12-13 Verus Pharmaceuticals, Inc. Methods for buccal, lingual or sublingual dosing regimens of epinephrine for the treatment of allergic emergencies
WO2007143676A2 (en) * 2006-06-05 2007-12-13 Verus Pharmaceuticals, Inc. Epinephrine dosing regimens comprising buccal, lingual or sublingual and injectable dosage forms
US20080069891A1 (en) 2006-09-15 2008-03-20 Cima Labs, Inc. Abuse resistant drug formulation
CA2659465A1 (en) * 2006-08-22 2008-02-28 Redpoint Bio Corporation Heterocyclic compounds as sweetener enhancers
US8445018B2 (en) 2006-09-15 2013-05-21 Cima Labs Inc. Abuse resistant drug formulation
WO2008033545A2 (en) * 2006-09-15 2008-03-20 Redpoint Bio Corporation Triphenylphosphine oxide derivatives and uses thereof
US20080153845A1 (en) * 2006-10-27 2008-06-26 Redpoint Bio Corporation Trpv1 antagonists and uses thereof
JP5649305B2 (en) * 2006-12-20 2015-01-07 テバ ウィメンズ ヘルス インコーポレイテッド Orally disintegrating solid dosage form containing progestin and method for producing and using the same
CA2677230A1 (en) * 2007-02-02 2008-08-14 Redpoint Bio Corporation Use of a trpm5 inhibitor to regulate insulin and glp-1 release
US20100010031A1 (en) 2007-02-09 2010-01-14 Yum Ii Su Transoral dosage forms comprising sufentanil and naloxone
ES2521494T3 (en) 2007-04-02 2014-11-12 Parkinson's Institute Methods and compositions for reducing the side effects of therapeutic treatments
JP2011507853A (en) 2007-12-20 2011-03-10 テバ ウィメンズ ヘルス インコーポレイテッド Dosage regimens and pharmaceutical compositions and packages for emergency contraception
WO2010077878A1 (en) * 2008-12-15 2010-07-08 Fleming And Company, Pharmaceuticals Rapidly dissolving vitamin formulation and methods of using the same
US20100163805A1 (en) * 2008-12-31 2010-07-01 Youngtack Shim Agent-containing media and methods therefor
US20110097401A1 (en) * 2009-06-12 2011-04-28 Meritage Pharma, Inc. Methods for treating gastrointestinal disorders
WO2011028671A1 (en) 2009-09-04 2011-03-10 Redpoint Bio Corporation Sweetness enhancers including rebaudioside a or d
CN102595932B (en) 2009-09-22 2014-07-16 红点生物公司 Novel polymorphs of rebaudioside C and methods for making and using the same
AU2010325746B2 (en) 2009-12-02 2016-02-25 Adare Pharmaceuticals S.R.L. Fexofenadine microcapsules and compositions containing them
TW201127375A (en) * 2010-01-08 2011-08-16 Eurand Inc Taste masked topiramate composition and an orally disintegrating tablet comprising the same
US20120322884A1 (en) 2010-03-01 2012-12-20 University Of Manitoba Epinephrine nanoparticles, methods of fabrication thereof, and methods for use thereof for treatment of conditions responsive to epinephrine
JP2013526523A (en) 2010-05-11 2013-06-24 シマ ラブス インク． Alcohol-resistant sustained release oral dosage form containing metoprolol
US20130017259A1 (en) 2011-07-06 2013-01-17 The Parkinson's Institute Compositions and Methods for Treatment of Symptoms in Parkinson's Disease Patients
WO2013022881A1 (en) 2011-08-08 2013-02-14 International Flavors & Fragrances Inc. Compositions and methods for the biosynthesis of vanillin or vanillin beta-d-glucoside
CA2853084C (en) 2011-10-21 2022-04-26 Nova Southeastern University Epinephrine nanoparticles, methods of fabrication thereof, and methods for use thereof for treatment of conditions responsive to epinephrine
WO2014145699A1 (en) * 2013-03-15 2014-09-18 New Jersey Institute Of Technology System and method for fabrication of uniform polymer films containing nano and micro particles via continuous drying process
HRP20211286T1 (en) 2013-03-22 2021-12-24 Nova Southeastern University Epinephrine fine particles and methods for use thereof for treatment of conditions responsive to epinephrine
EP3068227A4 (en) * 2013-11-11 2017-06-21 Forest Laboratories Holdings Limited Compositions and methods of treatment comprising fosfomycin disodium
EP2880992A3 (en) 2013-12-05 2015-06-17 International Flavors & Fragrances Inc. Rebaudioside C and its stereoisomers as natural product sweetness enhancers
US10213586B2 (en) 2015-01-28 2019-02-26 Chrono Therapeutics Inc. Drug delivery methods and systems
JP2018511127A (en) 2015-03-12 2018-04-19 クロノ セラピューティクス インコーポレイテッドＣｈｒｏｎｏ Ｔｈｅｒａｐｅｕｔｉｃｓ Ｉｎｃ． Craving input and support system
US10292977B2 (en) 2016-04-11 2019-05-21 Neurocea, LLC Compositions and methods for treatment related to fall and fall frequency in neurodegenerative diseases
US10143687B2 (en) 2016-04-11 2018-12-04 Neurocea, LLC Compositions and methods for treatment related to fall and fall frequency in neurodegenerative diseases
JP2020503950A (en) 2017-01-06 2020-02-06 クロノ セラピューティクス インコーポレイテッドＣｈｒｏｎｏ Ｔｈｅｒａｐｅｕｔｉｃｓ Ｉｎｃ． Device and method for transdermal drug delivery
WO2019232077A1 (en) 2018-05-29 2019-12-05 Chrono Therapeutics Inc. Drug delivery methods and systems

Family Cites Families (46)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3011950A (en) 1959-05-19 1961-12-05 Colgate Palmolive Co Liquid composition containing discrete gaseous bodies
US3142621A (en) 1961-11-02 1964-07-28 Ciba Geigy Corp Alginate suspensions of oral pharmaceutical compositions with improved taste qualities
US3456049A (en) 1965-05-25 1969-07-15 Ciba Geigy Corp Gradual-release tablet
US3885027A (en) * 1971-04-12 1975-05-20 West Laboratories Inc Orally administered drug composition for therapy in the treatment of narcotic drug addiction
DE2530563C2 (en) 1975-07-09 1986-07-24 Bayer Ag, 5090 Leverkusen Analgesic drugs with reduced potential for abuse
US4414198A (en) 1982-04-23 1983-11-08 Joseph Michaelson Rapidly disintegrable tablet composition and method
US4454110A (en) 1982-05-24 1984-06-12 Forsyth Dental Infirmary For Children Self-gelling liquid composition for topical application in the oral cavity
US4963367A (en) 1984-04-27 1990-10-16 Medaphore, Inc. Drug delivery compositions and methods
JPS6124516A (en) 1984-07-12 1986-02-03 Fujisawa Pharmaceut Co Ltd Long active tablet
US4610870A (en) 1984-10-05 1986-09-09 E. R. Squibb & Sons, Inc. Controlled release formulation
GB8426152D0 (en) 1984-10-16 1984-11-21 Reckitt & Colmann Prod Ltd Medicinal compositions
US5288497A (en) 1985-05-01 1994-02-22 The University Of Utah Compositions of oral dissolvable medicaments
US4687662A (en) * 1985-08-30 1987-08-18 Warner-Lambert Company Therapeutic effervescent composition
US4710384A (en) 1986-07-28 1987-12-01 Avner Rotman Sustained release tablets made from microcapsules
US5624683A (en) 1986-08-06 1997-04-29 Eisai Co., Ltd. Sustained-release multi-granule tablet
US5288500A (en) 1987-03-13 1994-02-22 Benzon Pharma A/S Oral composition containing particles comprising an active substance
US4950689A (en) 1987-03-31 1990-08-21 Yang Robert K Pectin delivery system
US5215752A (en) 1988-03-17 1993-06-01 Vectorpharma International S.P.A. Pharmaceutical tablets and capsule granulates of scleroglucan and active substance
US5273823A (en) 1988-10-11 1993-12-28 The Dow Chemical Company Shaped articles containing copolymers of polybenzazoles
US4883660A (en) 1988-10-17 1989-11-28 Thames Pharmacal Co., Inc. Gel bases for pharmaceutical compositions
US5133974A (en) 1989-05-05 1992-07-28 Kv Pharmaceutical Company Extended release pharmaceutical formulations
US5102664A (en) 1989-07-19 1992-04-07 Day Charles E Good-tasting gritty drug formulations
US5558880A (en) 1989-12-22 1996-09-24 Janssen Pharmaceutica Inc. Pharmaceutical and other dosage forms
SE9003904D0 (en) 1990-12-07 1990-12-07 Astra Ab METHOD FOR THE MANUFACTURE OF A PHARMACEUTICAL DOSAGE FORM
US5464632C1 (en) 1991-07-22 2001-02-20 Prographarm Lab Rapidly disintegratable multiparticular tablet
CA2116563C (en) 1991-08-30 2001-07-03 Yoji Ito Dry gel pharmaceutical composition
US5215758A (en) 1991-09-11 1993-06-01 Euroceltique, S.A. Controlled release matrix suppository for pharmaceuticals
US5192802A (en) 1991-09-25 1993-03-09 Mcneil-Ppc, Inc. Bioadhesive pharmaceutical carrier
US5318780A (en) 1991-10-30 1994-06-07 Mediventures Inc. Medical uses of in situ formed gels
US5545423A (en) 1991-11-25 1996-08-13 Vivorx, Inc. Cytoprotective, biocompatible, retrievable macrocapsule containment systems for biologically active materials
US5368862A (en) 1991-12-18 1994-11-29 Merck & Co., Inc. Sustained release tablets containing alginate
EP0627218B1 (en) * 1992-02-18 2001-12-19 Nippon Shinyaku Company, Limited Process for producing fast soluble tablets and fast soluble tablets comprising xylitol
US5422122A (en) 1992-08-04 1995-06-06 Eurand America, Incorporated Controlled release potassium chloride tablet
IL104283A (en) 1992-12-30 1996-12-05 Agis Ind 1983 Ltd Non-emulsion antiviral topical pharmaceutical composition comprising acyclovir an aqueous gel agent and an alkali oleate
US5562909A (en) 1993-07-12 1996-10-08 Massachusetts Institute Of Technology Phosphazene polyelectrolytes as immunoadjuvants
US5595761A (en) 1994-01-27 1997-01-21 The Board Of Regents Of The University Of Oklahoma Particulate support matrix for making a rapidly dissolving tablet
US5595760A (en) 1994-09-02 1997-01-21 Delab Sustained release of peptides from pharmaceutical compositions
FR2732217B1 (en) * 1995-03-29 1997-06-06 Hesnard Xavier SOLID ADMINISTRATION FORM FOR ORAL USE
JP2919771B2 (en) * 1995-04-17 1999-07-19 佐藤製薬株式会社 Method for producing fast-dissolving tablet and fast-dissolving tablet produced by the method
US20010014340A1 (en) * 1996-06-14 2001-08-16 Motohiro Ohta Intrabuccally rapidly disintegrating tablet
ATE400299T1 (en) * 1996-07-12 2008-07-15 Daiichi Seiyaku Co RAPIDLY DEGRADING, PRESSURE-FORMED MATERIALS AND THE PROCESS FOR THEIR PRODUCTION
FR2753097A1 (en) * 1996-09-11 1998-03-13 Barrau Francois Solid dosage form giving controlled viscosity solution or dispersion
KR100353304B1 (en) * 1996-10-01 2002-09-30 에스알아이 인터내셔널 Taste-masked microcapsule compositions and methods of manufacture
JPH10182436A (en) * 1996-10-31 1998-07-07 Takeda Chem Ind Ltd Solid medicinal preparation
JPH10167958A (en) * 1996-12-09 1998-06-23 Sankyo Co Ltd Loxoprofen sodium-containing oral cavity promptly soluble preparation and its production
US5728401A (en) * 1997-04-16 1998-03-17 Ranbaxy Laboratories, Ltd. Effervescent ranitidine formulations

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DE69931498T2 (en) 2007-03-01
AU742049B2 (en) 2001-12-13
DE69931498D1 (en) 2006-06-29
EP1104288B1 (en) 2006-05-24
JP2002522471A (en) 2002-07-23
ATE326951T1 (en) 2006-06-15
US6368625B1 (en) 2002-04-09
CA2339992C (en) 2006-01-03
AU5482399A (en) 2000-03-06
EP1104288A4 (en) 2003-04-16
EP1104288A1 (en) 2001-06-06

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